MCID: CHR091
MIFTS: 35

Chronic Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Chronic Meningitis

MalaCards integrated aliases for Chronic Meningitis:

Name: Chronic Meningitis 11 14 71 31

Classifications:



External Ids:

Disease Ontology 11 DOID:10341
ICD9CM 34 322.2
SNOMED-CT 68 21664006
ICD10 31 G03.1
UMLS 71 C0154653

Summaries for Chronic Meningitis

MalaCards based summary: Chronic Meningitis is related to cinca syndrome and eosinophilic meningitis. An important gene associated with Chronic Meningitis is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include spinal cord, brain and lymph node, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Chronic Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Chronic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 702)
# Related Disease Score Top Affiliating Genes
1 cinca syndrome 31.9 NLRP3 MEFV IL1B
2 eosinophilic meningitis 30.4 YWHAB MT-CO1 MMP9 MIR511 IL5 IL13
3 cysticercosis 30.2 MT-CO1 IL5 IL1B CD4
4 meningitis 29.9 NLRP3 MMP9 IL5 IL1B IL13 CRP
5 candidiasis 29.9 NLRP3 IL5 IL1B
6 myelitis 29.9 MMP9 MEFV CCL11
7 neurosarcoidosis 29.8 CRP CD4
8 granulomatous angiitis 29.8 CRP CD4
9 bacterial meningitis 29.8 MMP9 IL1B CRP
10 intracranial hypertension 29.6 IL1B CRP ALB
11 posterior uveitis 29.6 IL5 IL13 CD4
12 spinal cord disease 29.6 SERPINA3 CD4 ALB
13 neuroretinitis 29.5 CRP CD4
14 lyme disease 29.5 MMP9 IL1B CRP
15 nocardiosis 29.5 CRP CD4
16 vasculitis 29.5 SERPINA3 MEFV IL1B CRP
17 optic papillitis 29.5 NLRP3 CRP CD4
18 bell's palsy 29.5 CRP CD4 ALB
19 cranial nerve palsy 29.5 CRP CD4 ALB
20 arthropathy 29.5 NLRP3 IL1B CRP
21 lymphadenitis 29.4 SERPINA3 IL1B CRP
22 arachnoiditis 29.3 IL1B CRP CD4
23 viral infectious disease 29.3 SERPINA3 IL1B IL13 CD4
24 syphilis 29.3 CRP CD4 ALB
25 pleural empyema 29.2 CRP CD4 ALB
26 fungal meningitis 29.2 CRP CD4 ALB
27 facial paralysis 29.2 CRP CD4 ALB
28 meningoencephalitis 29.2 SERPINA3 IL1B CRP CD4 ALB
29 acquired immunodeficiency syndrome 29.1 IL1B CRP CD4 ALB
30 papilledema 29.1 SERPINA3 NLRP3 CRP CD4 ALB
31 exanthem 29.0 NLRP3 IL1B CRP CD4 ALB
32 stroke, ischemic 29.0 SERPINA3 MMP9 IL1B CRP ALB
33 aseptic meningitis 29.0 NLRP3 MEFV IL1B CRP CD4 ALB
34 brucellosis 28.9 NLRP3 MEFV IL13 CRP
35 immune deficiency disease 28.9 SERPINA3 IL1B IL13 CRP CD4 CCL11
36 sarcoidosis 1 28.7 SERPINA3 IL1B IL13 CRP CD4 CCL11
37 peripheral nervous system disease 28.5 SERPINA3 MMP9 IL1B CRP CD4 ALB
38 celiac disease 1 28.4 SERPINA3 IL5 IL1B IL13 CRP CD4
39 fungal infectious disease 28.3 IL5 IL1B IL13 CRP CD4 ALB
40 otitis media 28.2 NLRP3 IL5 IL1B IL13 CRP CCL11
41 systemic lupus erythematosus 27.6 MMP9 MEFV IL5 IL1B IL13 CRP
42 malaria 27.3 SERPINA3 NLRP3 MT-CO1 MMP9 IL5 IL1B
43 cryopyrin-associated periodic syndrome 11.0
44 hydrocephalus 10.4
45 contact blepharoconjunctivitis 10.3 IL5 CCL11
46 ancylostomiasis 10.3 MT-CO1 IL5
47 enterobiasis 10.3 MT-CO1 IL5
48 cercarial dermatitis 10.3 MT-CO1 IL5
49 angiokeratoma of fordyce 10.3 MMP9 IL5
50 cystoisosporiasis 10.2 MT-CO1 CD4

Comorbidity relations with Chronic Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Meningitis

Graphical network of the top 20 diseases related to Chronic Meningitis:



Diseases related to Chronic Meningitis

Symptoms & Phenotypes for Chronic Meningitis

MGI Mouse Phenotypes related to Chronic Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ALB CD4 CRP IL13 IL1B IL5
2 immune system MP:0005387 9.4 ALB CCL11 CD4 CRP IL13 IL1B

Drugs & Therapeutics for Chronic Meningitis

Search Clinical Trials, NIH Clinical Center for Chronic Meningitis

Genetic Tests for Chronic Meningitis

Anatomical Context for Chronic Meningitis

Organs/tissues related to Chronic Meningitis:

MalaCards : Spinal Cord, Brain, Lymph Node, Monocytes, Liver, Pituitary, Myeloid

Publications for Chronic Meningitis

Articles related to Chronic Meningitis:

(show top 50) (show all 453)
# Title Authors PMID Year
1
Isolated neurobrucellosis-characteristic clinical and laboratory features. 62
33394381 2022
2
Meningeal carcinomatosis secondary to neurenteric cysts with malignant transformation: a case report. 62
36384561 2022
3
Evaluation of the epidemiologic, clinical, radiologic, and treatment methods of patients with subacute and chronic meningitis. 62
36088290 2022
4
Chronic Meningitis Due to Otitis Media With Cholesteatoma in a Five-Year-Old Child With a Cochlear Implant. 62
36111453 2022
5
When time is short, and we are late!: A story of chronic meningitis. 62
36353026 2022
6
Focal Chronic Meningitis With Lymphoid Follicle-Like Structures Associated With Cocaine-Induced Midline Destructive Lesion: A Case Report. 62
35595306 2022
7
Discussing Challenges in Diagnosis of Tuberculous Meningitis and Neurosarcoidosis. 62
34165067 2022
8
Traumatic Rupture of a Skull Base Dermoid Cyst Mimicking Chronic Meningitis. 62
35719751 2022
9
Cranial Base Pachymeningitis in Children: Beyond Tuberculosis. 62
35027513 2022
10
Chronic Candida albicans meningitis misdiagnosed as polymyalgia rheumatica and successfully treated with voriconazole. 62
35387284 2022
11
Infectious Meningitis and Encephalitis. 62
34798976 2022
12
Ventriculoperitoneal shunt infection by Cryptococcus neoformans sensu stricto: Case report and literature review. 62
35248468 2022
13
Parkinsonism and prolonged cognitive decline as a manifestation of cryptococcal meningitis in a renal transplant patient. 62
35046073 2022
14
The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis). 62
36178925 2022
15
CNS Histoplasmosis as a Gliosarcoma mimicker: The diagnostic dilemma of solitary brain lesions. 62
35024338 2022
16
Neurobrucellosis: the great mimicker. 62
35416876 2022
17
Chronic Meningitis. 62
34469648 2021
18
[Chronic meningitis: etiologies and diagnostic work-up]. 62
34468099 2021
19
Subdural fluid collection rather than meningitis contributes to hydrocephalus after cervical laminoplasty: A case report. 62
34435016 2021
20
Sporothrix brasiliensis meningitis in an immunocompetent patient. 62
33627490 2021
21
Chronic Meningitis Due to Prototheca zopfii in an Adolescent Girl. 62
32415770 2021
22
Isolated Oculomotor Nerve Palsy - A Rare Initial Manifestation of Tuberculous Meningitis. 62
33187044 2020
23
The diagnostic utility of the "Thwaites' system" and "lancet consensus scoring system" in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients. 62
33096990 2020
24
Case Report: Chronic Fungal Meningitis Masquerading as Tubercular Meningitis. 62
32876006 2020
25
Primary leptomeningeal T-cell lymphoblastic lymphoma: a rare cause of chronic meningitis. 62
32958553 2020
26
Infliximab treatment in pathology-confirmed neurosarcoidosis. 62
32718952 2020
27
Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center. 62
32593044 2020
28
Mycobacterium chimaera and chronic meningitis. 62
31999345 2020
29
Skull base and calvarial tuberculosis presenting as chronic meningitis. 62
32825882 2020
30
Discrepancy between ventricular and lumbar CSF in chronic meningitis. 62
32553328 2020
31
Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. 62
32001377 2020
32
Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation. 62
31890490 2020
33
[Enteroviral infections in adults treated with rituximab: A new case of chronic meningitis and myofasciitis and literature review]. 62
31980187 2020
34
Fungal mycotic aneurysm in a patient with Aspergillus terreus chronic meningoencephalitis. 62
32547826 2020
35
Case Report: Candida dubliniensis as a Cause of Chronic Meningitis. 62
33363510 2020
36
Nocardia farcinica as a cause of chronic meningitis - case report. 62
31952512 2020
37
Reactivation of Histoplasmosis Disseminated into the Central Nervous System Presenting as a Stroke. 62
32025444 2019
38
Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. 62
30497968 2019
39
Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder. 62
31398970 2019
40
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 62
31439193 2019
41
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 62
31323746 2019
42
[Autoimmune chronic meningitis secondary to pneumococcal meningitis. Report of one case]. 62
31859835 2019
43
Chronic Candida dubliniensis meningitis in a lung transplant recipient. 62
30976504 2019
44
Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). 62
30997428 2019
45
Chronic meningitis with persistent hypoglycorrhachia: An unusual presentation of Lyme's disease. 62
31085878 2019
46
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. 62
30842137 2019
47
Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). 62
30066283 2019
48
Fungal and Parasitic CNS Infections. 62
29127615 2019
49
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 62
31367519 2019
50
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 62
30692758 2019

Variations for Chronic Meningitis

Expression for Chronic Meningitis

Search GEO for disease gene expression data for Chronic Meningitis.

Pathways for Chronic Meningitis

Pathways related to Chronic Meningitis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 YWHAB SERPINA3 NLRP3 MMP9 MEFV IL5
2
Show member pathways
13.12 MMP9 IL5 IL1B IL13 CD4 CCL11
3
Show member pathways
13.05 YWHAB NLRP3 MMP9 MEFV IL1B ADCY4
4
Show member pathways
12.24 YWHAB IL5 IL1B IL13
5
Show member pathways
11.83 IL5 IL1B IL13
6 11.77 CCL11 IL13 IL1B MMP9
7
Show member pathways
11.76 NLRP3 MEFV IL1B
8 11.69 IL5 IL1B IL13
9 11.53 IL5 IL1B IL13 CD4
10 11.28 NLRP3 MEFV IL1B
11 11.16 IL5 IL1B IL13
12 11.12 IL5 IL13 CD4 CCL11
13 11.08 NLRP3 MMP9 IL1B
14 10.96 NLRP3 MMP9 IL1B
15 10.82 MMP9 IL5 IL1B IL13 CCL11
16 10.72 IL5 IL1B IL13 CD4
17 10.51 IL5 IL1B IL13
18 10.36 NLRP3 IL1B

GO Terms for Chronic Meningitis

Biological processes related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.53 SERPINA3 NLRP3 MEFV IL5 IL1B IL13

Sources for Chronic Meningitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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