MCID: CHR091
MIFTS: 37

Chronic Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Meningitis

MalaCards integrated aliases for Chronic Meningitis:

Name: Chronic Meningitis 12 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:10341
ICD9CM 35 322.2
SNOMED-CT 68 21664006
ICD10 33 G03.1
UMLS 72 C0154653

Summaries for Chronic Meningitis

MalaCards based summary : Chronic Meningitis is related to cinca syndrome and meningitis. An important gene associated with Chronic Meningitis is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Propofol and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and neutrophil, and related phenotype is immune system.

Related Diseases for Chronic Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Chronic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 cinca syndrome 32.7 NLRP3 IL1RN
2 meningitis 31.2 NLRP3 MMP9 CRP
3 aseptic meningitis 30.2 NLRP3 IL1RN
4 granulomatous angiitis 30.0 IL5 CRP
5 bacterial meningitis 29.9 MMP9 CRP
6 lyme disease 29.8 MMP9 CRP
7 exanthem 29.4 NLRP3 IL1RN CRP
8 brucellosis 29.3 IL1RN CRP
9 eosinophilic meningitis 28.5 YWHAB MMP9 IL5 CCL11
10 muckle-wells syndrome 10.5 NLRP3 CRP
11 pericardial effusion 10.4 NLRP3 CRP
12 japanese spotted fever 10.4 CRP CCL11
13 diverticulitis 10.3 MMP9 CRP
14 pelvic inflammatory disease 10.3 MMP9 CRP
15 venous insufficiency 10.3 MMP9 CRP
16 leber optic atrophy 10.3 MT-ND4L MT-CO1
17 blepharitis 10.2 MMP9 CCL11
18 multicentric castleman disease 10.2 IL5 CRP
19 mesenteric lymphadenitis 10.2 IL5 CRP
20 preterm premature rupture of the membranes 10.2 MMP9 CRP
21 paragonimiasis 10.2 MT-CO1 IL5
22 hydrocephalus 10.2
23 congenital hydrocephalus 10.2
24 cercarial dermatitis 10.2 MT-CO1 IL5
25 keratoconjunctivitis 10.2 IL5 CCL11
26 appendicitis 10.2 MMP9 CRP
27 norwegian scabies 10.2 MT-CO1 IL5
28 pemphigoid gestationis 10.2 IL5 CCL11
29 strongyloidiasis 10.2 IL5 CCL11
30 carotid stenosis 10.2 MMP9 CRP
31 eosinophilic gastroenteritis 10.2 IL5 CCL11
32 esophagitis, eosinophilic, 1 10.2 IL5 CCL11
33 esophagitis 10.1 IL5 CCL11
34 chronic eosinophilic pneumonia 10.1 IL5 CCL11
35 eosinophilic pneumonia 10.1 IL5 CCL11
36 eosinophilic gastritis 10.1 IL5 CCL11
37 chronic conjunctivitis 10.1 IL5 CCL11
38 kimura disease 10.1 IL5 CCL11
39 folliculitis 10.1 IL5 CCL11
40 radiculopathy 10.1 IL5 CCL11
41 vulvar vestibulitis syndrome 10.1 NLRP3 IL1RN
42 carotid artery disease 10.1 MMP9 CRP
43 scleritis 10.1 MMP9 IL5
44 echinococcosis 10.1 MT-CO1 IL5
45 cysticercosis 10.1
46 acute cholangitis 10.1 IL1RN CRP
47 pulmonary eosinophilia 10.1 IL5 CCL11
48 aortic disease 10.1 NLRP3 MMP9 CRP
49 hyper-igd syndrome 10.1 IL1RN CRP
50 cartilage disease 10.1 IL1RN CRP

Comorbidity relations with Chronic Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Meningitis

Graphical network of the top 20 diseases related to Chronic Meningitis:



Diseases related to Chronic Meningitis

Symptoms & Phenotypes for Chronic Meningitis

MGI Mouse Phenotypes related to Chronic Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 CCL11 CRP IL1RN IL5 MMP9 MT-CO1

Drugs & Therapeutics for Chronic Meningitis

Drugs for Chronic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
2 Analgesics Phase 2
3 Central Nervous System Depressants Phase 2
4 Hypnotics and Sedatives Phase 2
5 Anesthetics Phase 2
6 Anesthetics, General Phase 2
7 Anesthetics, Intravenous Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol

Search NIH Clinical Center for Chronic Meningitis

Genetic Tests for Chronic Meningitis

Anatomical Context for Chronic Meningitis

MalaCards organs/tissues related to Chronic Meningitis:

41
Brain, Testes, Neutrophil, T Cells, Spinal Cord, Bone, Eye

Publications for Chronic Meningitis

Articles related to Chronic Meningitis:

(show top 50) (show all 413)
# Title Authors PMID Year
1
Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder. 38
31398970 2019
2
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 38
31323746 2019
3
Chronic Candida dubliniensis meningitis in a lung transplant recipient. 38
30976504 2019
4
Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). 38
30997428 2019
5
Chronic meningitis with persistent hypoglycorrhachia: An unusual presentation of Lyme's disease. 38
31085878 2019
6
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. 38
30842137 2019
7
Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). 38
30066283 2019
8
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 38
31367519 2019
9
Fungal and Parasitic CNS Infections. 38
29127615 2019
10
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 38
30692758 2019
11
Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. 38
30497968 2018
12
Diagnostic Approach to Chronic Meningitis. 38
30366558 2018
13
Chronic Meningitis. 38
30273241 2018
14
Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. 38
30107352 2018
15
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. 38
29710329 2018
16
What's Next (Generation) for the Diagnosis of Chronic Meningitis? 38
29710076 2018
17
A Fatal Case of Undiagnosed Candida Meningitis: Role of Computer-assisted Diagnosis. 38
29953039 2018
18
Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. 38
30030640 2018
19
Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity. 38
29977951 2018
20
[Cryopyrin-associated periodic syndromes]. 38
29111302 2018
21
Neurobrucellosis: diagnostic and clinical management of an atypical case. 38
29384559 2018
22
A Rare Presentation of Tubercular Meningitis as Persistent Neutrophilic Meningitis. 38
29379393 2017
23
Community-acquired Pseudomonas aeruginosa meningitis. 38
29054951 2017
24
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. 38
28598872 2017
25
Central Nervous System Blastomycosis in Children: A Case Report and Review of the Literature. 38
28033237 2017
26
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. 38
28709486 2017
27
[Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. 38
28929964 2017
28
Primary central nervous system natural killer/T-cell lymphoma: An atypical case of chronic meningitis. 38
28222909 2017
29
Tracing the footprints: A case of chronic meningitis with unusual mononuclear cells in the cerebrospinal fluid. 38
28188694 2017
30
Muckle-Wells syndrome in Chinese patients: a single center case series. 38
28028683 2017
31
Central Nervous System Tuberculosis. 38
28281443 2017
32
A Woman in Her 60s With Chronic Meningitis. 38
28114658 2017
33
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. 38
28263476 2017
34
The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host. 38
28042367 2017
35
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. 38
27325388 2016
36
Chronic meningitis, hydrocephalus and spinal paraplegia in non-systemic histoplasmosis. 38
27338647 2016
37
Brown Heroin-Associated Candida albicans Ventriculitis and Endophthalmitis Treated with Voriconazole. 38
27504092 2016
38
Mycobacterium abscessus as a Cause of Chronic Meningitis: A Rare Clinical Entity. 38
27079354 2016
39
Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. 38
27057889 2016
40
High-throughput sequencing of cerebrospinal fluid for diagnosis of chronic Propionibacterium acnes meningitis in an allogeneic stem cell transplant recipient. 38
26895706 2016
41
Chronic Meningitis: Simplifying a Diagnostic Challenge. 38
26888190 2016
42
Neurobrucellosis: an often forgotten cause of chronic meningitis. 38
26160851 2016
43
Clinical management of infectious cerebral vasculitides. 38
26689107 2016
44
Role of Coccidioides Antigen Testing in the Cerebrospinal Fluid for the Diagnosis of Coccidioidal Meningitis. 38
26209683 2015
45
Direct Invasion of the Optic Nerves, Chiasm, and Tracts by Cryptococcus neoformans in an Immunocompetent Host. 38
26425249 2015
46
Gliomatosis cerebri with spinal metastasis presenting with chronic meningitis in two boys. 38
26318497 2015
47
A 7-year-old girl with recurrent episodes of abdominal pain, seizures, and loss of vision: Primary diffuse leptomeningeal primitive neuroectodermal tumor masquerading as chronic meningitis. 38
26448234 2015
48
Approach to Chronic Lymphocytic Meningitis. 38
27608867 2015
49
Pleural effusion as the initial clinical presentation in disseminated cryptococcosis and fungaemia: an unusual manifestation and a literature review. 38
26395579 2015
50
Diagnostic Value and Safety of Brain Biopsy in Patients With Cryptogenic Neurological Disease: A Systematic Review and Meta-analysis of 831 Cases. 38
25856111 2015

Variations for Chronic Meningitis

Expression for Chronic Meningitis

Search GEO for disease gene expression data for Chronic Meningitis.

Pathways for Chronic Meningitis

GO Terms for Chronic Meningitis

Cellular components related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 MMP9 IL5 IL1RN CRP CCL11
2 respiratory chain GO:0070469 9.16 MT-ND4L MT-CO1
3 extracellular region GO:0005576 9.1 NLRP3 MMP9 IL5 IL1RN CRP CCL11

Biological processes related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 MMP9 IL5 IL1RN CCL11
2 inflammatory response GO:0006954 9.02 NLRP3 IL5 IL1RN CRP CCL11
3 response to interleukin-4 GO:0070670 8.65 CCL11

Molecular functions related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL5 IL1RN CCL11

Sources for Chronic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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