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MCID: CHR091
MIFTS: 38

Chronic Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Meningitis

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MalaCards integrated aliases for Chronic Meningitis:

Name: Chronic Meningitis 12 15 71 32

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:10341
ICD9CM 34 322.2
SNOMED-CT 67 21664006
ICD10 32 G03.1
UMLS 71 C0154653
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Summaries for Chronic Meningitis

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MalaCards based summary : Chronic Meningitis is related to cinca syndrome and meningitis. An important gene associated with Chronic Meningitis is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Propofol and Hypnotics and Sedatives have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and skin, and related phenotype is immune system.

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Related Diseases for Chronic Meningitis

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Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Chronic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 cinca syndrome 31.5 NLRP3 NLRP12 MVK MEFV IL1RN CRP
2 meningitis 30.7 NLRP3 MMP9 IL5 CRP CD40LG
3 granulomatous angiitis 30.4 IL5 CRP
4 aseptic meningitis 30.3 NLRP3 IL1RN CD40LG
5 neurosarcoidosis 30.3 CRP CD4
6 cysticercosis 30.1 MT-CO1 CD40LG CD4
7 arthropathy 30.0 NLRP3 IL1RN CRP
8 nocardiosis 29.9 CRP CD4
9 meningoencephalitis 29.9 CRP CD40LG CD4
10 asymptomatic neurosyphilis 29.9 CD40LG CD4
11 lymphadenitis 29.7 SERPINA3 CRP CD4
12 lyme disease 29.7 MMP9 CRP CD40LG
13 cranial nerve palsy 29.7 CRP CD40LG CD4
14 myelitis 29.7 MMP9 CD40LG CCL11
15 vasculitis 29.7 SERPINA3 MEFV CRP CD40LG
16 neuroretinitis 29.5 CRP CD40LG CD4
17 pleural empyema 29.5 CRP CD40LG CD4
18 facial paralysis 29.5 CRP CD40LG CD4
19 sarcoidosis 1 29.4 SERPINA3 IL1RN CRP CD40LG CD4
20 celiac disease 1 29.3 IL5 CRP CD40LG CD4
21 optic papillitis 29.3 NLRP3 CRP CD40LG CD4
22 brucellosis 29.2 MEFV IL1RN CRP CD40LG
23 cerebrovascular disease 29.2 SERPINA3 MMP9 CRP CD40LG
24 pancytopenia 29.2 SERPINA3 CRP CD40LG CD4
25 peripheral nervous system disease 29.2 SERPINA3 CRP CD40LG CD4
26 papilledema 29.0 NLRP3 IL1RN CRP CD40LG CD4
27 syphilis 28.9 NLRP12 CRP CD40LG CD4
28 eosinophilic meningitis 28.8 YWHAB MMP9 IL5 CD40LG CCL11
29 exanthem 28.7 NLRP3 MEFV IL1RN CRP CD40LG CD4
30 renal infectious disease 10.5 NLRP3 CRP
31 inflammatory bowel disease 23 10.5 IL1RN CRP
32 vulvar vestibulitis syndrome 10.5 NLRP3 IL1RN
33 baastrup's syndrome 10.5 IL1RN CRP
34 aspiration pneumonitis 10.4 SERPINA3 CRP
35 psoriatic juvenile idiopathic arthritis 10.4 NLRP3 MEFV
36 systemic autoimmune disease 10.4 MMP9 CRP
37 intestinal tuberculosis 10.4 CRP CD4
38 physical urticaria 10.4 SERPINA3 NLRP3 CRP
39 hereditary periodic fever syndrome 10.4 NLRP3 MEFV
40 cryopyrin-associated periodic syndrome 10.4 NLRP3 IL1RN CRP
41 autoinflammatory syndrome 10.4 NLRP3 NLRP12
42 atypical depressive disorder 10.4 SERPINA3 CRP
43 acute cholangitis 10.4 IL1RN CRP
44 amyloidosis aa 10.4 MEFV CRP
45 juvenile ankylosing spondylitis 10.4 MEFV IL1RN
46 odontogenic myxoma 10.4 SERPINA3 MMP9
47 pericardial tuberculosis 10.4 CRP CD4
48 cardiac rupture 10.4 MMP9 CRP
49 eosinophilic gastritis 10.4 IL5 CCL11
50 breast abscess 10.3 CRP CD4

Comorbidity relations with Chronic Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Meningitis

Graphical network of the top 20 diseases related to Chronic Meningitis:



Diseases related to Chronic Meningitis
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Symptoms & Phenotypes for Chronic Meningitis

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MGI Mouse Phenotypes related to Chronic Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCL11 CD4 CD40LG CRP IL1RN IL5
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Drugs & Therapeutics for Chronic Meningitis

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Drugs for Chronic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
2 Hypnotics and Sedatives Phase 2
3 Anesthetics Phase 2
4 Anesthetics, General Phase 2
5 Central Nervous System Depressants Phase 2
6 Anesthetics, Intravenous Phase 2
7 Analgesics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol

Search NIH Clinical Center for Chronic Meningitis

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Genetic Tests for Chronic Meningitis

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Anatomical Context for Chronic Meningitis

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MalaCards organs/tissues related to Chronic Meningitis:

40
Lung, Brain, Skin, Eye, Bone, Myeloid, Testes
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Publications for Chronic Meningitis

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Articles related to Chronic Meningitis:

(show top 50) (show all 421)
# Title Authors PMID Year
1
Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation. 61
31890490 2020
2
Nocardia farcinica as a cause of chronic meningitis - case report. 61
31952512 2020
3
[Enteroviral infections in adults treated with rituximab: A new case of chronic meningitis and myofasciitis and literature review]. 61
31980187 2020
4
Mycobacterium chimaera and chronic meningitis. 61
31999345 2020
5
Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. 61
32001377 2020
6
Reactivation of Histoplasmosis Disseminated into the Central Nervous System Presenting as a Stroke. 61
32025444 2019
7
Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. 61
30497968 2019
8
Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder. 61
31398970 2019
9
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 61
31439193 2019
10
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 61
31323746 2019
11
Chronic Candida dubliniensis meningitis in a lung transplant recipient. 61
30976504 2019
12
[Autoimmune chronic meningitis secondary to pneumococcal meningitis. Report of one case]. 61
31859835 2019
13
Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). 61
30997428 2019
14
Chronic meningitis with persistent hypoglycorrhachia: An unusual presentation of Lyme's disease. 61
31085878 2019
15
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. 61
30842137 2019
16
Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). 61
30066283 2019
17
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 61
31367519 2019
18
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 61
30692758 2019
19
Fungal and Parasitic CNS Infections. 61
29127615 2019
20
Diagnostic Approach to Chronic Meningitis. 61
30366558 2018
21
Chronic Meningitis. 61
30273241 2018
22
Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. 61
30107352 2018
23
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. 61
29710329 2018
24
What's Next (Generation) for the Diagnosis of Chronic Meningitis? 61
29710076 2018
25
A Fatal Case of Undiagnosed Candida Meningitis: Role of Computer-assisted Diagnosis. 61
29953039 2018
26
Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. 61
30030640 2018
27
Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity. 61
29977951 2018
28
[Cryopyrin-associated periodic syndromes]. 61
29111302 2018
29
Neurobrucellosis: diagnostic and clinical management of an atypical case. 61
29384559 2018
30
A Rare Presentation of Tubercular Meningitis as Persistent Neutrophilic Meningitis. 61
29379393 2017
31
Community-acquired Pseudomonas aeruginosa meningitis. 61
29054951 2017
32
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. 61
28598872 2017
33
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. 61
28709486 2017
34
Central Nervous System Blastomycosis in Children: A Case Report and Review of the Literature. 61
28033237 2017
35
[Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. 61
28929964 2017
36
Primary central nervous system natural killer/T-cell lymphoma: An atypical case of chronic meningitis. 61
28222909 2017
37
Tracing the footprints: A case of chronic meningitis with unusual mononuclear cells in the cerebrospinal fluid. 61
28188694 2017
38
Muckle-Wells syndrome in Chinese patients: a single center case series. 61
28028683 2017
39
Central Nervous System Tuberculosis. 61
28281443 2017
40
A Woman in Her 60s With Chronic Meningitis. 61
28114658 2017
41
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. 61
28263476 2017
42
The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host. 61
28042367 2017
43
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. 61
27325388 2016
44
Chronic meningitis, hydrocephalus and spinal paraplegia in non-systemic histoplasmosis. 61
27338647 2016
45
Brown Heroin-Associated Candida albicans Ventriculitis and Endophthalmitis Treated with Voriconazole. 61
27504092 2016
46
Mycobacterium abscessus as a Cause of Chronic Meningitis: A Rare Clinical Entity. 61
27079354 2016
47
Neurosarcoidosis in a Tertiary Referral Center: A Cross-Sectional Cohort Study. 61
27057889 2016
48
High-throughput sequencing of cerebrospinal fluid for diagnosis of chronic Propionibacterium acnes meningitis in an allogeneic stem cell transplant recipient. 61
26895706 2016
49
Chronic Meningitis: Simplifying a Diagnostic Challenge. 61
26888190 2016
50
Neurobrucellosis: an often forgotten cause of chronic meningitis. 61
26160851 2016
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Variations for Chronic Meningitis

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Expression for Chronic Meningitis

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Search GEO for disease gene expression data for Chronic Meningitis.
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Pathways for Chronic Meningitis

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Pathways related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 12.96 YWHAB SERPINA3 NLRP3 MMP9 MEFV IL5
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.91 YWHAB MMP9 IL5 IL1RN CD40LG CD4
3
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.43 MMP9 IL1RN CCL11
4
Lung fibrosis 1
11.34 MMP9 IL5 CCL11
5
IL4-mediated signaling events 1
11.3 IL5 CD40LG CCL11
6
Th2 Differentiation Pathway 64
10.99 IL5 CD4 CCL11
7
Nucleotide-binding Oligomerization Domain (NOD) pathway 1
10.74 NLRP3 NLRP12 MEFV
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GO Terms for Chronic Meningitis

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Cellular components related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.23 SERPINA3 NLRP3 MMP9 IL5 IL1RN CRP

Biological processes related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.65 IL5 IL1RN CD40LG CD4 CCL11
2 negative regulation of inflammatory response GO:0050728 9.46 NLRP3 NLRP12 MVK MEFV
3 cytokine-mediated signaling pathway GO:0019221 9.35 MMP9 IL5 IL1RN CD4 CCL11
4 inflammatory response GO:0006954 9.23 SERPINA3 NLRP3 MEFV IL5 IL1RN CRP

Molecular functions related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 YWHAB SERPINA3 PPIL2 NLRP3 NLRP12 MVK
2 identical protein binding GO:0042802 9.5 YWHAB NLRP3 MVK MMP9 MEFV CRP
3 cytokine activity GO:0005125 9.46 IL5 IL1RN CD40LG CCL11
Sources

Sources for Chronic Meningitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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