Chronic Meningitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Chronic Meningitis is related to cinca syndrome and eosinophilic meningitis. An important gene associated with Chronic Meningitis is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include spinal cord, brain and lymph node, and related phenotypes are homeostasis/metabolism and immune system

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Related Diseases for Chronic Meningitis

Diseases in the Meningitis family:

Viral Meningitis	Chronic Meningitis
Bacterial Meningitis

Diseases related to Chronic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 702)

#	Related Disease	Score	Top Affiliating Genes
1	cinca syndrome	31.9	NLRP3 MEFV IL1B
2	eosinophilic meningitis	30.4	YWHAB MT-CO1 MMP9 MIR511 IL5 IL13
3	cysticercosis	30.2	MT-CO1 IL5 IL1B CD4
4	meningitis	29.9	NLRP3 MMP9 IL5 IL1B IL13 CRP
5	candidiasis	29.9	NLRP3 IL5 IL1B
6	myelitis	29.9	MMP9 MEFV CCL11
7	neurosarcoidosis	29.8	CRP CD4
8	granulomatous angiitis	29.8	CRP CD4
9	bacterial meningitis	29.8	MMP9 IL1B CRP
10	intracranial hypertension	29.6	IL1B CRP ALB
11	posterior uveitis	29.6	IL5 IL13 CD4
12	spinal cord disease	29.6	SERPINA3 CD4 ALB
13	neuroretinitis	29.5	CRP CD4
14	lyme disease	29.5	MMP9 IL1B CRP
15	nocardiosis	29.5	CRP CD4
16	vasculitis	29.5	SERPINA3 MEFV IL1B CRP
17	optic papillitis	29.5	NLRP3 CRP CD4
18	bell's palsy	29.5	CRP CD4 ALB
19	cranial nerve palsy	29.5	CRP CD4 ALB
20	arthropathy	29.5	NLRP3 IL1B CRP
21	lymphadenitis	29.4	SERPINA3 IL1B CRP
22	arachnoiditis	29.3	IL1B CRP CD4
23	viral infectious disease	29.3	SERPINA3 IL1B IL13 CD4
24	syphilis	29.3	CRP CD4 ALB
25	pleural empyema	29.2	CRP CD4 ALB
26	fungal meningitis	29.2	CRP CD4 ALB
27	facial paralysis	29.2	CRP CD4 ALB
28	meningoencephalitis	29.2	SERPINA3 IL1B CRP CD4 ALB
29	acquired immunodeficiency syndrome	29.1	IL1B CRP CD4 ALB
30	papilledema	29.1	SERPINA3 NLRP3 CRP CD4 ALB
31	exanthem	29.0	NLRP3 IL1B CRP CD4 ALB
32	stroke, ischemic	29.0	SERPINA3 MMP9 IL1B CRP ALB
33	aseptic meningitis	29.0	NLRP3 MEFV IL1B CRP CD4 ALB
34	brucellosis	28.9	NLRP3 MEFV IL13 CRP
35	immune deficiency disease	28.9	SERPINA3 IL1B IL13 CRP CD4 CCL11
36	sarcoidosis 1	28.7	SERPINA3 IL1B IL13 CRP CD4 CCL11
37	peripheral nervous system disease	28.5	SERPINA3 MMP9 IL1B CRP CD4 ALB
38	celiac disease 1	28.4	SERPINA3 IL5 IL1B IL13 CRP CD4
39	fungal infectious disease	28.3	IL5 IL1B IL13 CRP CD4 ALB
40	otitis media	28.2	NLRP3 IL5 IL1B IL13 CRP CCL11
41	systemic lupus erythematosus	27.6	MMP9 MEFV IL5 IL1B IL13 CRP
42	malaria	27.3	SERPINA3 NLRP3 MT-CO1 MMP9 IL5 IL1B
43	cryopyrin-associated periodic syndrome	11.0
44	hydrocephalus	10.4
45	contact blepharoconjunctivitis	10.3	IL5 CCL11
46	ancylostomiasis	10.3	MT-CO1 IL5
47	enterobiasis	10.3	MT-CO1 IL5
48	cercarial dermatitis	10.3	MT-CO1 IL5
49	angiokeratoma of fordyce	10.3	MMP9 IL5
50	cystoisosporiasis	10.2	MT-CO1 CD4

Comorbidity relations with Chronic Meningitis via Phenotypic Disease Network (PDN):

Acute Cystitis

Meningitis

Graphical network of the top 20 diseases related to Chronic Meningitis:

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Symptoms & Phenotypes for Chronic Meningitis

MGI Mouse Phenotypes related to Chronic Meningitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	9.73	ALB CD4 CRP IL13 IL1B IL5
2	immune system	MP:0005387	9.4	ALB CCL11 CD4 CRP IL13 IL1B

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Drugs & Therapeutics for Chronic Meningitis

Search Clinical Trials, NIH Clinical Center for Chronic Meningitis

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Genetic Tests for Chronic Meningitis

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Anatomical Context for Chronic Meningitis

Organs/tissues related to Chronic Meningitis:

MalaCards : Spinal Cord, Brain, Lymph Node, Monocytes, Liver, Pituitary, Myeloid

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Publications for Chronic Meningitis

Articles related to Chronic Meningitis:

(show top 50) (show all 453)

#	Title	Authors	PMID	Year
1	Isolated neurobrucellosis-characteristic clinical and laboratory features. ⁶²	Dar W...Chandra A	33394381	2022
2	Meningeal carcinomatosis secondary to neurenteric cysts with malignant transformation: a case report. ⁶²	Chu M...Wu L	36384561	2022
3	Evaluation of the epidemiologic, clinical, radiologic, and treatment methods of patients with subacute and chronic meningitis. ⁶²	Bineshfar N...Darazam IA	36088290	2022
4	Chronic Meningitis Due to Otitis Media With Cholesteatoma in a Five-Year-Old Child With a Cochlear Implant. ⁶²	van Oorschot HD...Smit AL	36111453	2022
5	When time is short, and we are late!: A story of chronic meningitis. ⁶²	Chakraborty D...Majumder S	36353026	2022
6	Focal Chronic Meningitis With Lymphoid Follicle-Like Structures Associated With Cocaine-Induced Midline Destructive Lesion: A Case Report. ⁶²	Hamilton K...Hirsch-Reinshagen V	35595306	2022
7	Discussing Challenges in Diagnosis of Tuberculous Meningitis and Neurosarcoidosis. ⁶²	Santos A...Pantazou V	34165067	2022
8	Traumatic Rupture of a Skull Base Dermoid Cyst Mimicking Chronic Meningitis. ⁶²	Taha A...Shenoy A	35719751	2022
9	Cranial Base Pachymeningitis in Children: Beyond Tuberculosis. ⁶²	Mesquita AL...Borges MASB	35027513	2022
10	Chronic Candida albicans meningitis misdiagnosed as polymyalgia rheumatica and successfully treated with voriconazole. ⁶²	Giotaki I...Nau R	35387284	2022
11	Infectious Meningitis and Encephalitis. ⁶²	Bystritsky RJ...Chow FC	34798976	2022
12	Ventriculoperitoneal shunt infection by Cryptococcus neoformans sensu stricto: Case report and literature review. ⁶²	Kumar A...Chowdhary A	35248468	2022
13	Parkinsonism and prolonged cognitive decline as a manifestation of cryptococcal meningitis in a renal transplant patient. ⁶²	Nelles R...Denaro C	35046073	2022
14	The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis). ⁶²	Palackdkharry CS...Traynelis VC	36178925	2022
15	CNS Histoplasmosis as a Gliosarcoma mimicker: The diagnostic dilemma of solitary brain lesions. ⁶²	Khalaf SA...Bran A	35024338	2022
16	Neurobrucellosis: the great mimicker. ⁶²	Soares CN...Silva MTTD	35416876	2022
17	Chronic Meningitis. ⁶²	Aksamit AJ	34469648	2021
18	[Chronic meningitis: etiologies and diagnostic work-up]. ⁶²	Ammann S...Schmid R	34468099	2021
19	Subdural fluid collection rather than meningitis contributes to hydrocephalus after cervical laminoplasty: A case report. ⁶²	Huang HH...Zhao CQ	34435016	2021
20	Sporothrix brasiliensis meningitis in an immunocompetent patient. ⁶²	Lima MA...Silva MM	33627490	2021
21	Chronic Meningitis Due to Prototheca zopfii in an Adolescent Girl. ⁶²	Joerger T...Fox MD	32415770	2021
22	Isolated Oculomotor Nerve Palsy - A Rare Initial Manifestation of Tuberculous Meningitis. ⁶²	Singh AK...Baiswar R	33187044	2020
23	The diagnostic utility of the "Thwaites' system" and "lancet consensus scoring system" in tuberculous vs. non-tuberculous subacute and chronic meningitis: multicenter analysis of 395 adult patients. ⁶²	Sulaiman T...Hasbun R	33096990	2020
24	Case Report: Chronic Fungal Meningitis Masquerading as Tubercular Meningitis. ⁶²	Hesarur N...Sinha S	32876006	2020
25	Primary leptomeningeal T-cell lymphoblastic lymphoma: a rare cause of chronic meningitis. ⁶²	Elavarasi A...Kumar L	32958553	2020
26	Infliximab treatment in pathology-confirmed neurosarcoidosis. ⁶²	Fritz D...Brouwer MC	32718952	2020
27	Coccidioidal meningitis in non-AIDS patients. A case series at a Mexican neurological referral center. ⁶²	Cardenas G...Hernandez F	32593044	2020
28	Mycobacterium chimaera and chronic meningitis. ⁶²	Sharma K...Rowlinson MC	31999345	2020
29	Skull base and calvarial tuberculosis presenting as chronic meningitis. ⁶²	Bhoi SK...Pradhan N	32825882	2020
30	Discrepancy between ventricular and lumbar CSF in chronic meningitis. ⁶²	Patel B...Sardana V	32553328	2020
31	Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. ⁶²	Maji S...Chandrashekar N	32001377	2020
32	Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation. ⁶²	Gheshlaghi M...Helweg-Larsen J	31890490	2020
33	[Enteroviral infections in adults treated with rituximab: A new case of chronic meningitis and myofasciitis and literature review]. ⁶²	Maillet F...Amoura Z	31980187	2020
34	Fungal mycotic aneurysm in a patient with Aspergillus terreus chronic meningoencephalitis. ⁶²	Sangrador-Deitos MV...Soto Hernandez JL	32547826	2020
35	Case Report: Candida dubliniensis as a Cause of Chronic Meningitis. ⁶²	Tahir M...Jordan SJ	33363510	2020
36	Nocardia farcinica as a cause of chronic meningitis - case report. ⁶²	Moniuszko-Malinowska A...Pancewicz S	31952512	2020
37	Reactivation of Histoplasmosis Disseminated into the Central Nervous System Presenting as a Stroke. ⁶²	Klumpp L...Shah R	32025444	2019
38	Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. ⁶²	Hung PC...Wu CT	30497968	2019
39	Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder. ⁶²	Statler B...Janigian RH	31398970	2019
40	Panhypopituitarism- An unusual presenation of tuberculous meningitis. ⁶²	Sonkar SK...Singh NK	31439193	2019
41	Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. ⁶²	Kauffman CA	31323746	2019
42	[Autoimmune chronic meningitis secondary to pneumococcal meningitis. Report of one case]. ⁶²	Cea G...Cartier L	31859835	2019
43	Chronic Candida dubliniensis meningitis in a lung transplant recipient. ⁶²	Herrera S...Rotstein C	30976504	2019
44	Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). ⁶²	Galante-Mulki MC...Genoy-Puerto A	30997428	2019
45	Chronic meningitis with persistent hypoglycorrhachia: An unusual presentation of Lyme's disease. ⁶²	Farmania R...Gulati S	31085878	2019
46	Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. ⁶²	Elavarasi A...Jain D	30842137	2019
47	Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). ⁶²	Nair SB...Khubchandani RP	30066283	2019
48	Fungal and Parasitic CNS Infections. ⁶²	Singhi P...Saini AG	29127615	2019
49	Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. ⁶²	Narayanan S...Subramaniam G	31367519	2019
50	Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. ⁶²	Goyal V...Behari M	30692758	2019

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Genes for Chronic Meningitis

Genes related to Chronic Meningitis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	13.16	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders (show sections)
2	MIR511	MicroRNA 511	RNA Gene	7.96	DISEASES inferred ¹⁴ ¹⁴
3	AGFG1	ArfGAP With FG Repeats 1	Protein Coding	5.89	DISEASES inferred ¹⁴
4	SERPINA3	Serpin Family A Member 3	Protein Coding	5.74	DISEASES inferred ¹⁴ ¹⁴
5	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	5.71	DISEASES inferred ¹⁴
6	IL5	Interleukin 5	Protein Coding	5.68	DISEASES inferred ¹⁴
7	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	5.43	DISEASES inferred ¹⁴
8	MMP9	Matrix Metallopeptidase 9	Protein Coding	5.29	DISEASES inferred ¹⁴
9	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	5.28	DISEASES inferred ¹⁴
10	CD4	CD4 Molecule	Protein Coding	5.24	DISEASES inferred ¹⁴
11	IL1B	Interleukin 1 Beta	Protein Coding	5.05	DISEASES inferred ¹⁴
12	ADCY4	Adenylate Cyclase 4	Protein Coding	4.98	DISEASES inferred ¹⁴
13	IL13	Interleukin 13	Protein Coding	4.97	DISEASES inferred ¹⁴
14	MEFV	MEFV Innate Immunity Regulator, Pyrin	Protein Coding	4.96	DISEASES inferred ¹⁴
15	CRP	C-Reactive Protein	Protein Coding	4.95	DISEASES inferred ¹⁴
16	ALB	Albumin	Protein Coding	4.85	DISEASES inferred ¹⁴

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Variations for Chronic Meningitis

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Expression for Chronic Meningitis

Search GEO for disease gene expression data for Chronic Meningitis.

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Pathways for Chronic Meningitis

Pathways related to Chronic Meningitis according to GeneCards Suite gene sharing:

(show all 18)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.66	YWHAB SERPINA3 NLRP3 MMP9 MEFV IL5
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.12	MMP9 IL5 IL1B IL13 CD4 CCL11
3	ADORA2B mediated anti-inflammatory cytokines production ⁶⁶ Show member pathways Alpha-Adrenergic Signaling ⁶⁴ Androgen receptor signaling pathway ⁷⁴ Anti-inflammatory response favouring Leishmania parasite infection ⁶⁶ Beta-agonist/Beta-blocker Pathway, Pharmacodynamics ⁶⁰ CD163 mediating an anti-inflammatory response ⁶⁶ Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation ²² G alpha (z) signalling events ⁶⁶ G protein signaling pathways ⁷⁴ Glucagon signaling in metabolic regulation ⁶⁶ GPER1 signaling ⁶⁶ Hedgehog Signaling in Mammals ⁶⁴ Leishmania infection ⁶⁶ Leishmania parasite growth and survival ⁶⁶ LTC4-CYSLTR mediated IL4 production ⁶⁶ Relaxin Pathway ⁶⁴ Signal transduction cAMP signaling ²²	13.05	YWHAB NLRP3 MMP9 MEFV IL1B ADCY4
4	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.24	YWHAB IL5 IL1B IL13
5	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.83	IL5 IL1B IL13
6	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.77	CCL11 IL13 IL1B MMP9
7	Inflammasomes ⁶⁶ Show member pathways Cell recruitment (pro-inflammatory response) ⁶⁶ Influenza A virus infection ⁷⁴ Interleukin-1 processing ⁶⁶ Purinergic signaling in leishmaniasis infection ⁶⁶ The AIM2 inflammasome ⁶⁶ The NLRP1 inflammasome ⁶⁶ The NLRP3 inflammasome ⁶⁶	11.76	NLRP3 MEFV IL1B
8	Allograft rejection ⁷⁴	11.69	IL5 IL1B IL13
9	Innate Lymphoid Cells Differentiation ⁶⁵	11.53	IL5 IL1B IL13 CD4
10	Nucleotide-binding oligomerization domain (NOD) pathway ⁷⁴	11.28	NLRP3 MEFV IL1B
11	Development and heterogeneity of the ILC family ⁷⁴	11.16	IL5 IL1B IL13
12	Th2 Differentiation ⁶⁵	11.12	IL5 IL13 CD4 CCL11
13	Prostaglandin signaling ⁷⁴	11.08	NLRP3 MMP9 IL1B
14	IL1 and megakaryocytes in obesity ⁷⁴	10.96	NLRP3 MMP9 IL1B
15	Lung fibrosis ⁷⁴	10.82	MMP9 IL5 IL1B IL13 CCL11
16	Cytokines and inflammatory response ⁷⁴	10.72	IL5 IL1B IL13 CD4
17	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.51	IL5 IL1B IL13
18	Activation of NLRP3 inflammasome by SARS-CoV-2 ⁷⁴	10.36	NLRP3 IL1B

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GO Terms for Chronic Meningitis

Biological processes related to Chronic Meningitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.53	SERPINA3 NLRP3 MEFV IL5 IL1B IL13

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Sources for Chronic Meningitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CHR091 MIFTS: 35	Chronic Meningitis Categories: Infectious diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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