MCID: CHR091
MIFTS: 41

Chronic Meningitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Meningitis

MalaCards integrated aliases for Chronic Meningitis:

Name: Chronic Meningitis 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:10341
ICD9CM 34 322.2
SNOMED-CT 67 21664006
ICD10 32 G03.1
UMLS 71 C0154653

Summaries for Chronic Meningitis

MalaCards based summary : Chronic Meningitis is related to cinca syndrome and granulomatous angiitis. An important gene associated with Chronic Meningitis is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Propofol and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and neutrophil, and related phenotypes are cellular and hematopoietic system

Related Diseases for Chronic Meningitis

Diseases in the Meningitis family:

Viral Meningitis Chronic Meningitis
Bacterial Meningitis

Diseases related to Chronic Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 574)
# Related Disease Score Top Affiliating Genes
1 cinca syndrome 32.5 NLRP3 MEFV IL1RN IL1B
2 granulomatous angiitis 30.4 IL5 CRP
3 neurosarcoidosis 30.2 MIR642A CRP CD4
4 myelitis 30.1 MMP9 CD40LG CCL11
5 asymptomatic neurosyphilis 30.0 CD40LG CD4
6 cysticercosis 29.8 MT-CO1 IL1B CD40LG CD4
7 neuroretinitis 29.7 CRP CD40LG CD4
8 aseptic meningitis 29.7 NLRP3 IL1RN IL1B CRP CD40LG
9 nocardiosis 29.7 CRP CD4
10 optic papillitis 29.5 NLRP3 CRP CD40LG CD4
11 lyme disease 29.5 MMP9 IL1B CRP CD40LG
12 arthropathy 29.5 NLRP3 IL1RN IL1B CRP
13 lymphadenitis 29.4 IL1B CRP CD4
14 toxoplasmosis 29.4 IL5 IL1B CD40LG
15 bacterial meningitis 29.3 MMP9 IL1B CRP ALB
16 cranial nerve palsy 29.3 CRP CD40LG CD4 ALB
17 papilledema 29.2 NLRP3 IL1RN CRP CD40LG CD4
18 meningitis 29.1 NLRP3 MMP9 IL5 IL1B IL13 CRP
19 syphilis 29.1 CRP CD40LG CD4 ALB
20 pleural empyema 29.0 CRP CD40LG CD4 ALB
21 facial paralysis 29.0 CRP CD40LG CD4 ALB
22 pancytopenia 29.0 CRP CD40LG CD4 ALB
23 meningoencephalitis 28.9 IL1B CRP CD40LG CD4 ALB
24 brucellosis 28.8 MEFV IL1RN IL13 CRP CD40LG
25 acquired immunodeficiency syndrome 28.7 IL1B CRP CD40LG CD4 ALB
26 sarcoidosis 1 28.5 IL1RN IL1B IL13 CRP CD40LG CD4
27 peripheral nervous system disease 28.4 IL1B CRP CD40LG CD4 ALB
28 eosinophilic meningitis 28.3 YWHAB MT-CO1 MMP9 IL5 IL13 CD40LG
29 thrombocytopenia 28.0 NLRP3 MMP9 IL1RN IL1B CRP CD40LG
30 celiac disease 1 27.8 IL5 IL1B IL13 CRP CD40LG CD4
31 exanthem 27.7 NLRP3 MEFV IL1RN IL1B CRP CD40LG
32 systemic lupus erythematosus 26.4 NLRP3 MMP9 MIR642A IL5 IL1RN IL1B
33 anterior scleritis 10.5 IL1RN CRP
34 lateral ventricle meningioma 10.5 MMP9 CRP
35 systemic autoimmune disease 10.4 MMP9 CRP
36 renal infectious disease 10.4 NLRP3 CRP
37 focal chorioretinitis 10.4 NLRP3 CD40LG
38 hyper-igd syndrome 10.4 IL1RN CRP
39 cryopyrin-associated periodic syndrome 10.4 NLRP3 IL1RN CRP
40 japanese spotted fever 10.4 CRP CD40LG
41 psoriatic juvenile idiopathic arthritis 10.4 NLRP3 MEFV
42 chronic orbital inflammation 10.4 CRP CD40LG
43 prolapse of lacrimal gland 10.4 MMP9 CD40LG
44 pericardial tuberculosis 10.4 CRP CD4
45 hereditary periodic fever syndrome 10.4 NLRP3 MEFV
46 sarcocystosis 10.3 MT-CO1 CD40LG
47 cystoisosporiasis 10.3 MT-CO1 CD4
48 cytokine deficiency 10.3 IL5 IL13
49 ecthyma 10.3 CRP CD40LG
50 prosthetic joint infection 10.3 IL1B CRP

Comorbidity relations with Chronic Meningitis via Phenotypic Disease Network (PDN):


Acute Cystitis Meningitis

Graphical network of the top 20 diseases related to Chronic Meningitis:



Diseases related to Chronic Meningitis

Symptoms & Phenotypes for Chronic Meningitis

MGI Mouse Phenotypes related to Chronic Meningitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 AGFG1 ALB CD4 CD40LG IL13 IL1RN
2 hematopoietic system MP:0005397 10 CCL11 CD4 CD40LG IL13 IL1B IL1RN
3 homeostasis/metabolism MP:0005376 9.97 ALB CD4 CD40LG CRP IL13 IL1B
4 immune system MP:0005387 9.77 ALB CCL11 CD4 CD40LG CRP IL13
5 integument MP:0010771 9.23 CD4 CD40LG IL13 IL1B IL1RN MEFV

Drugs & Therapeutics for Chronic Meningitis

Drugs for Chronic Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 2 2078-54-8 4943
2 Anesthetics Phase 2
3 Analgesics Phase 2
4 Anesthetics, General Phase 2
5 Hypnotics and Sedatives Phase 2
6 Anesthetics, Intravenous Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Single-dose Propofol Injection on Pain and Quality of Life in Chronic Daily Headache: a Randomized Double-blind Controlled Trial Completed NCT00228267 Phase 2 Propofol

Search NIH Clinical Center for Chronic Meningitis

Genetic Tests for Chronic Meningitis

Anatomical Context for Chronic Meningitis

MalaCards organs/tissues related to Chronic Meningitis:

40
Brain, Testes, Neutrophil, Liver, T Cells, Spinal Cord, Eye

Publications for Chronic Meningitis

Articles related to Chronic Meningitis:

(show top 50) (show all 424)
# Title Authors PMID Year
1
Chronic Meningitis Due to Prototheca zopfii in an Adolescent Girl. 61
32415770 2020
2
Discrepancy between ventricular and lumbar CSF in chronic meningitis. 61
32553328 2020
3
Neurobrucellosis: A neglected entity? An update from tertiary care Neurocentre of South East Asia. 61
32001377 2020
4
Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation. 61
31890490 2020
5
[Enteroviral infections in adults treated with rituximab: A new case of chronic meningitis and myofasciitis and literature review]. 61
31980187 2020
6
Nocardia farcinica as a cause of chronic meningitis - case report. 61
31952512 2020
7
Mycobacterium chimaera and chronic meningitis. 61
31999345 2020
8
Fungal mycotic aneurysm in a patient with Aspergillus terreus chronic meningoencephalitis. 61
32547826 2020
9
Reactivation of Histoplasmosis Disseminated into the Central Nervous System Presenting as a Stroke. 61
32025444 2019
10
Primary intracranial meningeal melanoma mimicking chronic meningitis: A case report. 61
30497968 2019
11
Bilateral Serous Retinal Detachment from Neonatal-Onset Multisystemic Inflammatory Disorder. 61
31398970 2019
12
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 61
31439193 2019
13
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 61
31323746 2019
14
Chronic Candida dubliniensis meningitis in a lung transplant recipient. 61
30976504 2019
15
[Autoimmune chronic meningitis secondary to pneumococcal meningitis. Report of one case]. 61
31859835 2019
16
Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). 61
30997428 2019
17
Chronic meningitis with persistent hypoglycorrhachia: An unusual presentation of Lyme's disease. 61
31085878 2019
18
Leptomeningeal leukaemia misdiagnosed as tubercular meningitis. 61
30842137 2019
19
Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). 61
30066283 2019
20
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 61
31367519 2019
21
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 61
30692758 2019
22
Fungal and Parasitic CNS Infections. 61
29127615 2019
23
Diagnostic Approach to Chronic Meningitis. 61
30366558 2018
24
Chronic Meningitis. 61
30273241 2018
25
Clinical diagnostic utility of contrast-enhanced three-dimensional fluid-attenuated inversion recovery for selection of brain biopsy sites in neurosarcoidosis: A case report. 61
30107352 2018
26
Chronic Meningitis Investigated via Metagenomic Next-Generation Sequencing. 61
29710329 2018
27
What's Next (Generation) for the Diagnosis of Chronic Meningitis? 61
29710076 2018
28
A Fatal Case of Undiagnosed Candida Meningitis: Role of Computer-assisted Diagnosis. 61
29953039 2018
29
Paediatric diffuse leptomeningeal tumor with glial and neuronal differentiation harbouring chromosome 1p/19q co-deletion and H3.3 K27M mutation: unusual molecular profile and its therapeutic implications. 61
30030640 2018
30
Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity. 61
29977951 2018
31
[Cryopyrin-associated periodic syndromes]. 61
29111302 2018
32
Neurobrucellosis: diagnostic and clinical management of an atypical case. 61
29384559 2018
33
A Rare Presentation of Tubercular Meningitis as Persistent Neutrophilic Meningitis. 61
29379393 2017
34
Community-acquired Pseudomonas aeruginosa meningitis. 61
29054951 2017
35
Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. 61
28598872 2017
36
Diagnosis of tuberculous meningitis: Current scenario from a Tertiary Neurocare Centre in India. 61
28709486 2017
37
Central Nervous System Blastomycosis in Children: A Case Report and Review of the Literature. 61
28033237 2017
38
[Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods]. 61
28929964 2017
39
Primary central nervous system natural killer/T-cell lymphoma: An atypical case of chronic meningitis. 61
28222909 2017
40
Tracing the footprints: A case of chronic meningitis with unusual mononuclear cells in the cerebrospinal fluid. 61
28188694 2017
41
Muckle-Wells syndrome in Chinese patients: a single center case series. 61
28028683 2017
42
Central Nervous System Tuberculosis. 61
28281443 2017
43
A Woman in Her 60s With Chronic Meningitis. 61
28114658 2017
44
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. 61
28263476 2017
45
The Upside of Bias: A Case of Chronic Meningitis Due to Sporothrix Schenckii in an Immunocompetent Host. 61
28042367 2017
46
An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination. 61
27325388 2016
47
Chronic meningitis, hydrocephalus and spinal paraplegia in non-systemic histoplasmosis. 61
27338647 2016
48
Brown Heroin-Associated Candida albicans Ventriculitis and Endophthalmitis Treated with Voriconazole. 61
27504092 2016
49
High-throughput sequencing of cerebrospinal fluid for diagnosis of chronic Propionibacterium acnes meningitis in an allogeneic stem cell transplant recipient. 61
26895706 2016
50
Mycobacterium abscessus as a Cause of Chronic Meningitis: A Rare Clinical Entity. 61
27079354 2016

Variations for Chronic Meningitis

Expression for Chronic Meningitis

Search GEO for disease gene expression data for Chronic Meningitis.

Pathways for Chronic Meningitis

Pathways related to Chronic Meningitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 YWHAB NLRP3 MMP9 MEFV IL5 IL1RN
2
Show member pathways
13.27 YWHAB IL5 IL1B IL13 CD40LG CD4
3
Show member pathways
13.08 YWHAB MMP9 IL5 IL1RN IL1B IL13
4
Show member pathways
12.68 IL5 IL1B IL13 CD40LG CD4 CCL11
5
Show member pathways
12.31 YWHAB IL5 IL1B IL13
6
Show member pathways
12.17 MMP9 IL5 IL1B IL13 CCL11
7 12.05 YWHAB IL1RN IL1B IL13
8 11.85 MMP9 IL1B IL13 CCL11
9 11.77 IL5 IL1B CD4
10 11.61 IL5 IL1B IL13 CD4
11
Show member pathways
11.54 MMP9 IL1B CD40LG
12 11.53 IL5 CD40LG CCL11
13 11.41 IL1RN IL1B IL13
14 11.31 NLRP3 MEFV IL1B
15 11.19 IL5 IL1B IL13
16 11.12 IL5 IL13 CD4 CCL11
17 11.05 NLRP3 MMP9 IL1B
18 10.88 IL5 IL1B IL13 CD40LG CCL11
19 10.82 MMP9 IL5 IL1B IL13 CCL11
20 10.72 IL5 IL1B IL13 CD4
21 10.62 IL5 IL1B IL13

GO Terms for Chronic Meningitis

Cellular components related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 MMP9 IL5 IL1RN IL1B IL13 CRP
2 extracellular region GO:0005576 9.32 NLRP3 MMP9 IL5 IL1RN IL1B IL13

Biological processes related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.7 IL5 IL1RN IL1B IL13 CD40LG CD4
2 cytokine-mediated signaling pathway GO:0019221 9.5 MMP9 IL5 IL1RN IL1B IL13 CD4
3 positive regulation of T cell proliferation GO:0042102 9.43 IL1B CD40LG CD4
4 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.37 IL1B CD4
5 interleukin-1 beta production GO:0032611 9.32 NLRP3 IL1B
6 inflammatory response GO:0006954 9.28 NLRP3 MEFV IL5 IL1RN IL1B IL13

Molecular functions related to Chronic Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 YWHAB NLRP3 MT-CO1 MMP9 MEFV IL5
2 identical protein binding GO:0042802 9.7 YWHAB NLRP3 MMP9 MEFV CRP CD4
3 cytokine activity GO:0005125 9.1 IL5 IL1RN IL1B IL13 CD40LG CCL11

Sources for Chronic Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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