MCID: CHR064
MIFTS: 34

Chronic Monocytic Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases

Aliases & Classifications for Chronic Monocytic Leukemia

MalaCards integrated aliases for Chronic Monocytic Leukemia:

Name: Chronic Monocytic Leukemia 12 15
Leukemia, Monocytic, Chronic 73
Leukemia, Myeloid 44

Classifications:



External Ids:

Disease Ontology 12 DOID:8593
ICD10 33 C93.1
ICD9CM 35 206.1
MeSH 44 D007951
NCIt 50 C34774
UMLS 73 C0023466

Summaries for Chronic Monocytic Leukemia

MalaCards based summary : Chronic Monocytic Leukemia, also known as leukemia, monocytic, chronic, is related to leukemia, acute myeloid and myeloid leukemia. An important gene associated with Chronic Monocytic Leukemia is C3 (Complement C3), and among its related pathways/superpathways are Sertoli-Sertoli Cell Junction Dynamics and Focal Adhesion. Affiliated tissues include monocytes and myeloid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Monocytic Leukemia

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Chronic Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 31.7 CD34 ITGAM MPO PTPRC
2 myeloid leukemia 11.7
3 leukemia, chronic myeloid 11.5
4 atypical chronic myeloid leukemia 11.1
5 hypersensitivity vasculitis 10.6 C3 MPO
6 hypersensitivity reaction type iii disease 10.6 C3 MPO
7 periodontosis 10.5 ITGAM MPO
8 henoch-schoenlein purpura 10.5 C3 MPO
9 retina lymphoma 10.4 CD34 MPO
10 endometrial small cell carcinoma 10.4 F2 PTPRC
11 dendritic cell tumor 10.4 MPO PTPRC
12 extracutaneous mastocytoma 10.4 CD34 PTPRC
13 liver inflammatory pseudotumor 10.4 CD34 PTPRC
14 myeloid sarcoma 10.4 MPO PTPRC
15 chronic maxillary sinusitis 10.4 C3 MPO
16 glomeruloid hemangioma 10.4 CD34 PTPRC
17 spleen angiosarcoma 10.3 CD34 PTEN
18 extraosseous osteosarcoma 10.3 CD34 PTPRC
19 melanotic neurilemmoma 10.3 CD34 PTEN
20 diffuse cutaneous mastocytosis 10.3 CD34 PTPRC
21 sarcomatoid squamous cell skin carcinoma 10.3 CD34 PTPRC
22 vulvar sarcoma 10.3 CD34 PTPRC
23 conventional fibrosarcoma 10.3 CD34 PTPRC
24 aleukemic leukemia cutis 10.3 CD34 MPO
25 hemangioma of liver 10.3 CD34 F2
26 eccrine adenocarcinoma 10.2 CD34 F2
27 ascending cholangitis 10.2 C3 F2 MPO
28 peritonitis 10.2 F2 ITGAM MPO
29 reticulohistiocytic granuloma 10.2 CD34 PTPRC
30 arteritic anterior ischemic optic neuropathy 10.2 F2 MPO
31 afibrinogenemia, congenital 10.1 C3 F2
32 leukemia 10.1
33 monocytic leukemia 10.1
34 essential thrombocythemia 10.1 F2 ITGAM MPO
35 lymphocytic vasculitis 10.1 ITGAM ITGAX
36 precursor t-cell acute lymphoblastic leukemia 10.0 CD34 MPO PTEN
37 gastrointestinal system cancer 9.9 CD34 F2 PTEN
38 afibrinogenemia 9.8 C3 F2
39 vascular disease 9.6 F2 ITGAM MPO
40 myocardial infarction 9.4 CD34 F2 ITGAM MPO
41 lymphoma, non-hodgkin, familial 9.1 CD34 ITGAX PTPRC
42 acute promyelocytic leukemia 8.7 CD34 ITGAM ITGAX MPO PTPRC

Graphical network of the top 20 diseases related to Chronic Monocytic Leukemia:



Diseases related to Chronic Monocytic Leukemia

Symptoms & Phenotypes for Chronic Monocytic Leukemia

GenomeRNAi Phenotypes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.4 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.4 ITGAM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.4 PTPRC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.4 PTPRC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.4 PTEN
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 PTPRC
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 F2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 ITGAM PTEN PTPRC F2

MGI Mouse Phenotypes related to Chronic Monocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CD34 F2 ITGAD ITGAM ITGAX MPO
2 homeostasis/metabolism MP:0005376 9.61 C3 CD34 F2 ITGAD ITGAM LGALS1
3 immune system MP:0005387 9.32 CD34 F2 ITGAD ITGAM ITGAX LGALS1

Drugs & Therapeutics for Chronic Monocytic Leukemia

Search Clinical Trials , NIH Clinical Center for Chronic Monocytic Leukemia

Cochrane evidence based reviews: leukemia, myeloid

Genetic Tests for Chronic Monocytic Leukemia

Anatomical Context for Chronic Monocytic Leukemia

MalaCards organs/tissues related to Chronic Monocytic Leukemia:

41
Monocytes, Myeloid

Publications for Chronic Monocytic Leukemia

Articles related to Chronic Monocytic Leukemia:

# Title Authors Year
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. ( 23995854 )
2013
2
BCR-ABL translocation in a dog with chronic monocytic leukemia. ( 21143615 )
2011
3
Chronic monocytic leukemia terminating in blastic transformation. ( 3465380 )
1986
4
Chronic monocytic leukemia in adults. ( 6945897 )
1981
5
[Clinical morphological, cytogenetic and genealogical studies of patients with chronic monocytic leukemia]. ( 284662 )
1979
6
Chronic monocytic leukemia. ( 276262 )
1978
7
Chronic monocytic leukemia: a case with an eight-year survival. ( 5240097 )
1967
8
Chronic monocytic leukemia in childhood. ( 13576375 )
1958

Variations for Chronic Monocytic Leukemia

Expression for Chronic Monocytic Leukemia

Search GEO for disease gene expression data for Chronic Monocytic Leukemia.

Pathways for Chronic Monocytic Leukemia

Pathways related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 ITGAD ITGAM ITGAX PTEN
2
Show member pathways
12.65 ITGAD ITGAM ITGAX PTEN
3
Show member pathways
12.62 ITGAD ITGAM ITGAX PTEN
4 12.32 F2 ITGAD ITGAM ITGAX
5 12.25 CD34 LGALS1 MPO PTPRC
6
Show member pathways
12.18 ITGAD ITGAM ITGAX
7
Show member pathways
11.99 F2 ITGAM ITGAX
8 11.98 C3 ITGAM ITGAX
9 11.89 C3 ITGAM MPO
10
Show member pathways
11.88 ITGAD ITGAM ITGAX
11 11.83 CD34 ITGAM PTPRC
12
Show member pathways
11.78 C3 ITGAM ITGAX
13 11.78 ITGAD ITGAM ITGAX PTEN
14 11.7 C3 F2 ITGAM ITGAX
15 11.48 CD34 ITGAM PTPRC
16 11.39 C3 ITGAD ITGAM ITGAX
17 11.37 ITGAD ITGAM ITGAX
18 11.29 ITGAD ITGAM ITGAX
19 11.29 ITGAD ITGAM ITGAX
20 11.13 CD34 ITGAM ITGAX PTPRC
21 11.09 CD34 ITGAM ITGAX MPO PTPRC

GO Terms for Chronic Monocytic Leukemia

Cellular components related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.43 CD34 ITGAD ITGAM ITGAX LGALS1 PTPRC
2 integrin complex GO:0008305 9.33 ITGAD ITGAM ITGAX
3 external side of plasma membrane GO:0009897 9.02 CD34 F2 ITGAM ITGAX PTPRC

Biological processes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.73 CD34 ITGAD ITGAM ITGAX
2 cellular protein metabolic process GO:0044267 9.58 C3 F2 LGALS1
3 extracellular matrix organization GO:0030198 9.54 ITGAD ITGAM ITGAX
4 integrin-mediated signaling pathway GO:0007229 9.33 ITGAD ITGAM ITGAX
5 heterotypic cell-cell adhesion GO:0034113 9.32 ITGAD ITGAX
6 amyloid-beta clearance GO:0097242 9.26 C3 ITGAM
7 leukocyte migration GO:0050900 9.26 CD34 F2 ITGAM ITGAX
8 neutrophil degranulation GO:0043312 9.02 C3 ITGAM ITGAX MPO PTPRC

Sources for Chronic Monocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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