MCID: CHR064
MIFTS: 36

Chronic Monocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Chronic Monocytic Leukemia

MalaCards integrated aliases for Chronic Monocytic Leukemia:

Name: Chronic Monocytic Leukemia 12 15
Leukemia, Monocytic, Chronic 74
Leukemia, Myeloid 45

Classifications:



External Ids:

Disease Ontology 12 DOID:8593
ICD9CM 36 206.1
MeSH 45 D007951
NCIt 51 C34774
ICD10 34 C93.1
UMLS 74 C0023466

Summaries for Chronic Monocytic Leukemia

MalaCards based summary : Chronic Monocytic Leukemia, also known as leukemia, monocytic, chronic, is related to leukemia, acute myeloid and myeloid sarcoma. An important gene associated with Chronic Monocytic Leukemia is C3 (Complement C3), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. Affiliated tissues include monocytes, myeloid and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Monocytic Leukemia

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Chronic Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 31.4 CD34 ITGAM ITGAX MPO PTPRC
2 myeloid sarcoma 30.5 MPO PTPRC
3 acute promyelocytic leukemia 28.5 CD34 ITGAM ITGAX MPO PTPRC
4 myeloid leukemia 11.9
5 leukemia, chronic myeloid 11.7
6 atypical chronic myeloid leukemia 11.3
7 leukemia 10.3
8 monocytic leukemia 10.3
9 periodontosis 10.2 ITGAM MPO
10 hypersensitivity vasculitis 10.2 C3 MPO
11 granulocytopenia 10.2 ITGAM MPO
12 hypersensitivity reaction type iii disease 10.2 C3 MPO
13 chronic maxillary sinusitis 10.2 C3 MPO
14 henoch-schoenlein purpura 10.2 C3 MPO
15 retina lymphoma 10.2 CD34 MPO
16 dendritic cell tumor 10.2 MPO PTPRC
17 endometrial small cell carcinoma 10.2 F2 PTPRC
18 extracutaneous mastocytoma 10.2 CD34 PTPRC
19 liver inflammatory pseudotumor 10.2 CD34 PTPRC
20 glomeruloid hemangioma 10.1 CD34 PTPRC
21 vulvar sarcoma 10.1 CD34 PTPRC
22 conventional fibrosarcoma 10.1 CD34 PTPRC
23 aleukemic leukemia cutis 10.1 CD34 MPO
24 lymphocytic leukemia 10.1
25 sarcoma 10.1
26 proliferative glomerulonephritis 10.1 C3 MPO
27 hemangioma of liver 10.1 CD34 F2
28 reticulohistiocytic granuloma 10.1 CD34 PTPRC
29 eccrine adenocarcinoma 10.1 CD34 F2
30 arteritic anterior ischemic optic neuropathy 10.1 F2 MPO
31 ascending cholangitis 10.0 C3 F2 MPO
32 peritonitis 10.0 F2 ITGAM MPO
33 essential thrombocythemia 10.0 F2 ITGAM MPO
34 lymphocytic vasculitis 10.0 ITGAM ITGAX
35 leukemia, acute lymphoblastic 10.0
36 afibrinogenemia 10.0 C3 F2
37 acute leukemia 9.9
38 acute lymphoblastic leukemia, childhood 9.9
39 precursor t-cell acute lymphoblastic leukemia 9.9 CD34 MPO PTEN
40 gastrointestinal system cancer 9.9 CD34 F2 PTEN
41 afibrinogenemia, congenital 9.8 C3 F2
42 vascular disease 9.8 F2 ITGAM MPO
43 leukemia, chronic lymphocytic 2 9.7
44 leukemia, chronic lymphocytic 9.7
45 carney complex, type 1 9.7
46 caronte 9.7
47 juvenile myelomonocytic leukemia 9.7
48 lymphoid leukemia 9.7
49 lymphoma 9.7
50 hairy cell leukemia 9.7

Graphical network of the top 20 diseases related to Chronic Monocytic Leukemia:



Diseases related to Chronic Monocytic Leukemia

Symptoms & Phenotypes for Chronic Monocytic Leukemia

GenomeRNAi Phenotypes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.4 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.4 ITGAM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.4 PTPRC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.4 PTPRC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.4 PTEN
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 PTPRC
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.4 F2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 F2 ITGAM PTEN PTPRC

MGI Mouse Phenotypes related to Chronic Monocytic Leukemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 C3 CD34 F2 ITGAD ITGAM ITGAX
2 homeostasis/metabolism MP:0005376 9.61 C3 CD34 F2 ITGAD ITGAM LGALS1
3 immune system MP:0005387 9.32 C3 CD34 F2 ITGAD ITGAM ITGAX

Drugs & Therapeutics for Chronic Monocytic Leukemia

Search Clinical Trials , NIH Clinical Center for Chronic Monocytic Leukemia

Cochrane evidence based reviews: leukemia, myeloid

Genetic Tests for Chronic Monocytic Leukemia

Anatomical Context for Chronic Monocytic Leukemia

MalaCards organs/tissues related to Chronic Monocytic Leukemia:

42
Monocytes, Myeloid, Liver, Bone, Bone Marrow, T Cells, Retina

Publications for Chronic Monocytic Leukemia

Articles related to Chronic Monocytic Leukemia:

# Title Authors Year
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. ( 23995854 )
2013
2
BCR-ABL translocation in a dog with chronic monocytic leukemia. ( 21143615 )
2011
3
Chronic monocytic leukemia terminating in blastic transformation. ( 3465380 )
1986
4
Chronic monocytic leukemia in adults. ( 6945897 )
1981
5
[Clinical morphological, cytogenetic and genealogical studies of patients with chronic monocytic leukemia]. ( 284662 )
1979
6
Chronic monocytic leukemia. ( 276262 )
1978
7
Functional characteristics of chronic monocytic "leukemia". ( 4214610 )
1974
8
Chronic monocytic leukemia: a case with an eight-year survival. ( 5240097 )
1967
9
Chronic monocytic leukemia in childhood. ( 13576375 )
1958

Variations for Chronic Monocytic Leukemia

Expression for Chronic Monocytic Leukemia

Search GEO for disease gene expression data for Chronic Monocytic Leukemia.

Pathways for Chronic Monocytic Leukemia

Pathways related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 C3 CD34 ITGAM ITGAX MPO PTEN
2
Show member pathways
13.15 F2 ITGAD ITGAM ITGAX PTEN
3
Show member pathways
12.84 ITGAD ITGAM ITGAX PTEN
4
Show member pathways
12.7 ITGAD ITGAM ITGAX PTEN
5
Show member pathways
12.67 ITGAD ITGAM ITGAX PTEN
6
Show member pathways
12.62 ITGAD ITGAM ITGAX PTEN
7 12.34 F2 ITGAD ITGAM ITGAX
8 12.27 CD34 LGALS1 MPO PTPRC
9
Show member pathways
12.2 ITGAD ITGAM ITGAX
10
Show member pathways
12 F2 ITGAD ITGAM ITGAX
11
Show member pathways
12 F2 ITGAM ITGAX
12 12 C3 ITGAM ITGAX
13 11.92 C3 ITGAM MPO
14
Show member pathways
11.91 ITGAD ITGAM ITGAX
15
Show member pathways
11.89 ITGAD ITGAM ITGAX PTEN
16 11.85 CD34 ITGAM PTPRC
17
Show member pathways
11.8 C3 ITGAM ITGAX
18 11.78 ITGAD ITGAM ITGAX PTEN
19 11.7 ITGAD ITGAM ITGAX
20 11.7 C3 F2 ITGAM ITGAX
21 11.52 ITGAD ITGAM ITGAX
22 11.51 CD34 ITGAM PTPRC
23 11.39 ITGAD ITGAM ITGAX
24 11.39 C3 ITGAD ITGAM ITGAX
25 11.38 CD34 PTPRC
26 11.33 ITGAM MPO
27 11.32 ITGAD ITGAM ITGAX
28 11.3 ITGAD ITGAM ITGAX
29 11.29 ITGAM PTPRC
30 11.18 ITGAD ITGAM ITGAX
31 11.13 CD34 ITGAM ITGAX PTPRC
32 11.09 CD34 ITGAM ITGAX MPO PTPRC

GO Terms for Chronic Monocytic Leukemia

Cellular components related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.92 C3 CD34 F2 ITGAD ITGAM ITGAX
2 extracellular region GO:0005576 9.85 C3 CD34 F2 LGALS1 MPO PTEN
3 extracellular exosome GO:0070062 9.73 C3 F2 ITGAM LGALS1 MPO PTPRC
4 endoplasmic reticulum lumen GO:0005788 9.58 C3 F2 LGALS1
5 cytoplasmic side of plasma membrane GO:0009898 9.43 PTEN PTPRC
6 external side of plasma membrane GO:0009897 9.35 CD34 F2 ITGAM ITGAX PTPRC
7 integrin complex GO:0008305 9.33 ITGAD ITGAM ITGAX
8 cell surface GO:0009986 9.1 CD34 ITGAD ITGAM ITGAX LGALS1 PTPRC

Biological processes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.76 CD34 ITGAD ITGAM ITGAX
2 cellular protein metabolic process GO:0044267 9.65 C3 F2 LGALS1
3 extracellular matrix organization GO:0030198 9.61 ITGAD ITGAM ITGAX
4 leukocyte migration GO:0050900 9.58 CD34 ITGAM ITGAX
5 integrin-mediated signaling pathway GO:0007229 9.43 ITGAD ITGAM ITGAX
6 amyloid-beta clearance GO:0097242 9.37 C3 ITGAM
7 neutrophil degranulation GO:0043312 9.35 C3 ITGAM ITGAX MPO PTPRC
8 cell surface receptor signaling pathway involved in cell-cell signaling GO:1905114 9.16 C3 ITGAM
9 positive regulation of phagocytosis, engulfment GO:0060100 9.02 C3
10 heterotypic cell-cell adhesion GO:0034113 8.8 ITGAD ITGAX PTPRC

Molecular functions related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 F2 MPO PTPRC

Sources for Chronic Monocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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