MCID: CHR064
MIFTS: 44

Chronic Monocytic Leukemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Chronic Monocytic Leukemia

MalaCards integrated aliases for Chronic Monocytic Leukemia:

Name: Chronic Monocytic Leukemia 12 15
Leukemia, Monocytic, Chronic 73
Leukemia, Myeloid 44

Classifications:



External Ids:

Disease Ontology 12 DOID:8593
ICD10 33 C93.1
ICD9CM 35 206.1
MeSH 44 D007951
NCIt 50 C34774
UMLS 73 C0023466

Summaries for Chronic Monocytic Leukemia

MalaCards based summary : Chronic Monocytic Leukemia, also known as leukemia, monocytic, chronic, is related to leukemia, acute myeloid and myeloid sarcoma. An important gene associated with Chronic Monocytic Leukemia is C3 (Complement C3), and among its related pathways/superpathways are Integrin Pathway and Sertoli-Sertoli Cell Junction Dynamics. Affiliated tissues include myeloid, monocytes and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Chronic Monocytic Leukemia

Diseases in the Monocytic Leukemia family:

Leukemia, Acute Monocytic Adult Acute Monocytic Leukemia
Chronic Monocytic Leukemia Subacute Monocytic Leukemia

Diseases related to Chronic Monocytic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 leukemia, acute myeloid 31.8 CD34 ITGAM ITGAX MPO PTPRC
2 myeloid sarcoma 30.4 MPO PTPRC
3 acute promyelocytic leukemia 29.1 CD34 ITGAM ITGAX MPO PTPRC
4 myeloid leukemia 11.9
5 leukemia, chronic myeloid 11.7
6 atypical chronic myeloid leukemia 11.3
7 monocytic leukemia 10.2
8 leukemia 10.2
9 periodontosis 10.2 ITGAM MPO
10 hypersensitivity vasculitis 10.2 C3 MPO
11 granulocytopenia 10.2 ITGAM MPO
12 hypersensitivity reaction type iii disease 10.2 C3 MPO
13 chronic maxillary sinusitis 10.1 C3 MPO
14 endometrial small cell carcinoma 10.1 F2 PTPRC
15 dendritic cell tumor 10.1 MPO PTPRC
16 retina lymphoma 10.1 CD34 MPO
17 henoch-schoenlein purpura 10.1 C3 MPO
18 extracutaneous mastocytoma 10.1 CD34 PTPRC
19 liver inflammatory pseudotumor 10.1 CD34 PTPRC
20 glomeruloid hemangioma 10.1 CD34 PTPRC
21 vulvar sarcoma 10.1 CD34 PTPRC
22 conventional fibrosarcoma 10.1 CD34 PTPRC
23 aleukemic leukemia cutis 10.1 CD34 MPO
24 hemangioma of liver 10.1 CD34 F2
25 proliferative glomerulonephritis 10.1 C3 MPO
26 eccrine adenocarcinoma 10.1 CD34 F2
27 ascending cholangitis 10.1 C3 F2 MPO
28 arteritic anterior ischemic optic neuropathy 10.1 F2 MPO
29 reticulohistiocytic granuloma 10.1 CD34 PTPRC
30 peritonitis 10.1 F2 ITGAM MPO
31 essential thrombocythemia 10.0 F2 ITGAM MPO
32 lymphocytic vasculitis 10.0 ITGAM ITGAX
33 afibrinogenemia 10.0 C3 F2
34 lymphocytic leukemia 10.0
35 sarcoma 10.0
36 precursor t-cell acute lymphoblastic leukemia 10.0 CD34 MPO PTEN
37 gastrointestinal system cancer 9.9 CD34 F2 PTEN
38 acute leukemia 9.9
39 leukemia, acute lymphoblastic 9.8
40 myocardial infarction 9.8 CD34 F2 ITGAM MPO
41 vascular disease 9.8 F2 ITGAM MPO
42 lymphoma, non-hodgkin, familial 9.7 CD34 ITGAX PTPRC
43 leukemia, chronic lymphocytic 2 9.7
44 leukemia, chronic lymphocytic 9.7
45 noonan syndrome 1 9.7
46 lysosomal acid lipase deficiency 9.7
47 juvenile myelomonocytic leukemia 9.7
48 acute lymphoblastic leukemia, childhood 9.7
49 acute lymphocytic leukemia 9.7
50 adult acute lymphocytic leukemia 9.7

Graphical network of the top 20 diseases related to Chronic Monocytic Leukemia:



Diseases related to Chronic Monocytic Leukemia

Symptoms & Phenotypes for Chronic Monocytic Leukemia

GenomeRNAi Phenotypes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.44 PTPRC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.44 ITGAM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.44 ITGAM
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 PTPRC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.44 PTPRC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.44 PTPRC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.44 PTEN
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 PTPRC
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.44 F2
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.44 F2 ITGAM PTEN PTPRC

MGI Mouse Phenotypes related to Chronic Monocytic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 C3 CD34 F2 ITGAD ITGAM ITGAX
2 homeostasis/metabolism MP:0005376 9.61 C3 CD34 F2 ITGAD ITGAM LGALS1
3 immune system MP:0005387 9.32 C3 CD34 F2 ITGAD ITGAM ITGAX

Drugs & Therapeutics for Chronic Monocytic Leukemia

Search Clinical Trials , NIH Clinical Center for Chronic Monocytic Leukemia

Cochrane evidence based reviews: leukemia, myeloid

Genetic Tests for Chronic Monocytic Leukemia

Anatomical Context for Chronic Monocytic Leukemia

MalaCards organs/tissues related to Chronic Monocytic Leukemia:

41
Myeloid, Monocytes, Bone, T Cells, Bone Marrow, Nk Cells, Liver

Publications for Chronic Monocytic Leukemia

Articles related to Chronic Monocytic Leukemia:

# Title Authors Year
1
Partial cytogenetic response with toceranib and prednisone treatment in a young dog with chronic monocytic leukemia. ( 23995854 )
2013
2
BCR-ABL translocation in a dog with chronic monocytic leukemia. ( 21143615 )
2011
3
Chronic monocytic leukemia terminating in blastic transformation. ( 3465380 )
1986
4
Chronic monocytic leukemia in adults. ( 6945897 )
1981
5
[Clinical morphological, cytogenetic and genealogical studies of patients with chronic monocytic leukemia]. ( 284662 )
1979
6
Chronic monocytic leukemia. ( 276262 )
1978
7
Chronic monocytic leukemia: a case with an eight-year survival. ( 5240097 )
1967
8
Chronic monocytic leukemia in childhood. ( 13576375 )
1958

Variations for Chronic Monocytic Leukemia

Expression for Chronic Monocytic Leukemia

Search GEO for disease gene expression data for Chronic Monocytic Leukemia.

Pathways for Chronic Monocytic Leukemia

Pathways related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 F2 ITGAD ITGAM ITGAX PTEN
2
Show member pathways
12.7 ITGAD ITGAM ITGAX PTEN
3
Show member pathways
12.67 ITGAD ITGAM ITGAX PTEN
4
Show member pathways
12.63 ITGAD ITGAM ITGAX PTEN
5 12.34 F2 ITGAD ITGAM ITGAX
6 12.27 CD34 LGALS1 MPO PTPRC
7
Show member pathways
12.2 ITGAD ITGAM ITGAX
8
Show member pathways
12 F2 ITGAD ITGAM ITGAX
9
Show member pathways
12 F2 ITGAM ITGAX
10 12 C3 ITGAM ITGAX
11 11.92 C3 ITGAM MPO
12
Show member pathways
11.9 ITGAD ITGAM ITGAX
13
Show member pathways
11.89 ITGAD ITGAM ITGAX PTEN
14 11.84 CD34 ITGAM PTPRC
15
Show member pathways
11.8 C3 ITGAM ITGAX
16 11.78 ITGAD ITGAM ITGAX PTEN
17 11.7 ITGAD ITGAM ITGAX
18 11.7 C3 F2 ITGAM ITGAX
19 11.51 CD34 ITGAM PTPRC
20 11.39 ITGAD ITGAM ITGAX
21 11.39 C3 ITGAD ITGAM ITGAX
22 11.3 ITGAD ITGAM ITGAX
23 11.3 ITGAD ITGAM ITGAX
24 11.29 ITGAM PTPRC
25 11.18 ITGAD ITGAM ITGAX
26 11.13 CD34 ITGAM ITGAX PTPRC
27 11.09 CD34 ITGAM ITGAX MPO PTPRC

GO Terms for Chronic Monocytic Leukemia

Cellular components related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 C3 F2 ITGAM LGALS1 MPO PTPRC
2 external side of plasma membrane GO:0009897 9.35 CD34 F2 ITGAM ITGAX PTPRC
3 integrin complex GO:0008305 9.33 ITGAD ITGAM ITGAX
4 cell surface GO:0009986 9.1 CD34 ITGAD ITGAM ITGAX LGALS1 PTPRC

Biological processes related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.78 CD34 ITGAD ITGAM ITGAX
2 cellular protein metabolic process GO:0044267 9.63 C3 F2 LGALS1
3 extracellular matrix organization GO:0030198 9.61 ITGAD ITGAM ITGAX
4 leukocyte migration GO:0050900 9.58 CD34 ITGAM ITGAX
5 neutrophil degranulation GO:0043312 9.55 C3 ITGAM ITGAX MPO PTPRC
6 integrin-mediated signaling pathway GO:0007229 9.43 ITGAD ITGAM ITGAX
7 amyloid-beta clearance GO:0097242 9.37 C3 ITGAM
8 positive regulation of phagocytosis, engulfment GO:0060100 9.32 C3 ITGAM
9 cell surface receptor signaling pathway involved in cell-cell signaling GO:1905114 8.96 C3 ITGAM
10 heterotypic cell-cell adhesion GO:0034113 8.8 ITGAD ITGAX PTPRC

Molecular functions related to Chronic Monocytic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 F2 MPO PTPRC

Sources for Chronic Monocytic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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