MCID: CHR063
MIFTS: 65

Chronic Mucocutaneous Candidiasis

Categories: Rare diseases, Skin diseases, Blood diseases, Infectious diseases

Aliases & Classifications for Chronic Mucocutaneous Candidiasis

MalaCards integrated aliases for Chronic Mucocutaneous Candidiasis:

Name: Chronic Mucocutaneous Candidiasis 12 53 59 37 29 15
Candidiasis, Chronic Mucocutaneous 44 73
Cmc 53 59
Candidiasis Chronic Mucocutaneous 55

Characteristics:

Orphanet epidemiological data:

59
chronic mucocutaneous candidiasis
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Childhood,Infancy;

Classifications:



Summaries for Chronic Mucocutaneous Candidiasis

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 1334Disease definitionChronic mucocutaneous candidosis (CMC) refers to a group of heterogenous disorders characterized by persistent, debilitating and/or recurrent infections of the skin, nails, and mucus membranes, mainly with the fungal pathogen Candida albicans.Visit the Orphanet disease page for more resources.

MalaCards based summary : Chronic Mucocutaneous Candidiasis, also known as candidiasis, chronic mucocutaneous, is related to familial candidiasis and autoimmune polyendocrine syndrome, and has symptoms including scaling of skin lesions, thickening of nails and swollen periungal tissue. An important gene associated with Chronic Mucocutaneous Candidiasis is IL17F (Interleukin 17F), and among its related pathways/superpathways are NOD-like receptor signaling pathway and Phagosome. The drugs Miconazole and Antifungal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, mucous membrane and nail due to t-cell defects, and related phenotypes are recurrent urinary tract infections and abnormality of the vagina

Disease Ontology : 12 A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located in skin, located in mucous membrane, or located in nail due to T-cell defects, has-agent Candida species and has symptom scaling of skin lesions, has symptom thickening of nails, has symptom swollen periungal tissue, and has symptom scarring of the scalp.

Wikipedia : 76 Chronic mucocutaneous candidiasis is an immune disorder of T cells, it is characterized by chronic... more...

Related Diseases for Chronic Mucocutaneous Candidiasis

Diseases related to Chronic Mucocutaneous Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 familial candidiasis 33.6 CARD9 IL17F IL17RA
2 autoimmune polyendocrine syndrome 31.1 AIRE IL17A IL22
3 alopecia areata 31.0 AIRE IFNG IL2RA
4 meningitis 30.6 IFNG IL10 IL6
5 myasthenia gravis 30.6 AIRE IFNG IL10
6 candidiasis 27.8 AIRE CARD9 CLEC7A HSP90AA1 IFNG IL10
7 candidiasis, familial, 4 11.9
8 candidiasis, familial, 2 11.8
9 immunodeficiency 51 11.8
10 immunodeficiency 31c 11.8
11 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.6
12 autoimmune polyendocrine syndrome type 1 11.5
13 candidiasis, familial, 1 11.3
14 candidiasis, familial, 6 11.2
15 candidiasis, familial, 8 11.1
16 capillary malformations, congenital 11.1
17 chudley-mccullough syndrome 11.1
18 chronic inflammatory demyelinating polyradiculoneuropathy 10.8 IFNG IL17A STAT1
19 acute generalized exanthematous pustulosis 10.7 IL17A IL17F IL22
20 cutaneous candidiasis 10.7 IL17A IL2RA
21 nasopharyngitis 10.7 IL17A IL17F IL17RA
22 nasopharyngeal disease 10.7 IL17A IL17F IL17RA
23 paranasal sinus disease 10.6 IFNG IL10 IL17A
24 aspergillosis 10.6 CLEC7A IFNG IL10
25 allergic contact dermatitis 10.6 IFNG IL10 IL17A
26 eye lymphoma 10.6 IL10 IL6
27 hyperlucent lung 10.6 IFNG IL10 IL2RA
28 acute transverse myelitis 10.6 IL10 IL6
29 mixed lacrimal gland cancer 10.6 IL6 STAT3
30 chronic graft versus host disease 10.6 IFNG IL10 IL2RA
31 relapsing-remitting multiple sclerosis 10.5 IFNG IL10 IL17A
32 transverse myelitis 10.5 IL10 IL17A IL6
33 extrinsic cardiomyopathy 10.5 IL10 IL17A IL6
34 b-cell growth factor 10.5 IFNG IL6
35 acute graft versus host disease 10.5 IFNG IL10 IL2RA
36 multicentric castleman disease 10.5 IFNG IL10 IL6
37 vogt-koyanagi-harada disease 10.5 IL10 IL17A IL2RA
38 eales disease 10.5 IFNG IL10 IL6
39 hemorrhagic fever 10.5 IFNG IL10 IL6
40 plasmodium vivax malaria 10.5 IFNG IL10 IL6
41 omenn syndrome 10.5 AIRE IFNG IL10
42 large granular lymphocyte leukemia 10.5 IL2RA STAT3
43 trichosporonosis 10.5 IFNG IL17A
44 paracoccidioidomycosis 10.5 IFNG IL10 IL6
45 mixed connective tissue disease 10.5 IFNG IL10 IL6
46 reactive arthritis 10.5 IFNG IL10 IL6
47 melioidosis 10.5 IFNG IL10 IL6
48 human immunodeficiency virus infectious disease 10.5 IFNG IL10 IL6
49 polyradiculoneuropathy 10.5 IFNG IL10 IL17A STAT1
50 filariasis 10.5 IFNG IL10 IL6

Graphical network of the top 20 diseases related to Chronic Mucocutaneous Candidiasis:



Diseases related to Chronic Mucocutaneous Candidiasis

Symptoms & Phenotypes for Chronic Mucocutaneous Candidiasis

Symptoms:

12
  • scaling of skin lesions
  • thickening of nails
  • swollen periungal tissue
  • scarring of the scalp

Human phenotypes related to Chronic Mucocutaneous Candidiasis:

59 32 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent urinary tract infections 59 32 occasional (7.5%) Occasional (29-5%) HP:0000010
2 abnormality of the vagina 59 32 frequent (33%) Frequent (79-30%) HP:0000142
3 abnormality of vision 59 32 occasional (7.5%) Occasional (29-5%) HP:0000504
4 abnormality of dental enamel 59 32 occasional (7.5%) Occasional (29-5%) HP:0000682
5 hematuria 59 32 occasional (7.5%) Occasional (29-5%) HP:0000790
6 hyperkeratosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000962
7 skin rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0000988
8 pruritus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000989
9 abnormality of the fingernails 59 32 hallmark (90%) Very frequent (99-80%) HP:0001231
10 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
11 broad nail 59 32 hallmark (90%) Very frequent (99-80%) HP:0001821
12 hemoptysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002105
13 recurrent respiratory infections 59 32 occasional (7.5%) Occasional (29-5%) HP:0002205
14 abnormality of temperature regulation 59 32 occasional (7.5%) Occasional (29-5%) HP:0004370
15 feeding difficulties in infancy 59 32 occasional (7.5%) Occasional (29-5%) HP:0008872
16 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
17 hepatitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012115
18 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
19 dyspareunia 59 32 frequent (33%) Frequent (79-30%) HP:0030016
20 cheilitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100825
21 papule 59 32 frequent (33%) Frequent (79-30%) HP:0200034
22 skin ulcer 59 32 hallmark (90%) Very frequent (99-80%) HP:0200042
23 abnormality of the mouth 59 Very frequent (99-80%)
24 abnormality of the lip 59 Very frequent (99-80%)
25 abnormality of the eye 59 Occasional (29-5%)
26 abnormality of the skin 59 Very frequent (99-80%)
27 abnormality of the nail 59 Very frequent (99-80%)
28 abnormality of the immune system 59 Very frequent (99-80%)
29 recurrent infections 59 Very frequent (99-80%)
30 abnormality of the endocardium 59 Occasional (29-5%)
31 abnormality of the toenails 59 Very frequent (99-80%)
32 abnormal endocardium morphology 32 occasional (7.5%) HP:0004306
33 abnormal toenail morphology 32 hallmark (90%) HP:0008388

GenomeRNAi Phenotypes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CLEC7A HSP90AA1 IL17A IL17RC IL23A IL2RA

MGI Mouse Phenotypes related to Chronic Mucocutaneous Candidiasis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.36 CLEC7A IL17A IFNG AIRE IL10 IL2RA
2 hematopoietic system MP:0005397 10.36 CLEC7A IL17A IFNG AIRE CARD9 IL10
3 immune system MP:0005387 10.36 CLEC7A HSP90AA1 IL17A IFNG AIRE IL10
4 homeostasis/metabolism MP:0005376 10.31 IL10 CLEC7A IFNG AIRE CARD9 IL17RA
5 growth/size/body region MP:0005378 10.29 IL10 HSP90AA1 IFNG AIRE IL2RA IL17RB
6 endocrine/exocrine gland MP:0005379 10.24 IL10 HSP90AA1 IFNG AIRE IL2RA IL17A
7 mortality/aging MP:0010768 10.18 IL10 CLEC7A HSP90AA1 IFNG AIRE IL2RA
8 craniofacial MP:0005382 10.07 IL10 HSP90AA1 IFNG IL17A IL17F STAT3
9 neoplasm MP:0002006 9.97 IL10 IFNG AIRE IL17RA IL23A IL23R
10 respiratory system MP:0005388 9.93 CLEC7A IL17A IFNG AIRE IL10 IL17RA
11 no phenotypic analysis MP:0003012 9.8 IL10 IFNG AIRE IL23R IL17RA IL17A
12 skeleton MP:0005390 9.61 IL10 HSP90AA1 IFNG IL17RB IL17A IL17F
13 vision/eye MP:0005391 9.23 IL10 IFNG AIRE IL2RA STAT1 STAT3

Drugs & Therapeutics for Chronic Mucocutaneous Candidiasis

Drugs for Chronic Mucocutaneous Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
2 Antifungal Agents Phase 3,Phase 2
3
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antiparasitic Agents Phase 2
7 Antiprotozoal Agents Phase 2
8 Autoantibodies Phase 2,Phase 1
9 Liposomal amphotericin B Phase 2
10
rituximab Approved Phase 1 174722-31-7 10201696
11 Antibodies Phase 1
12 Antibodies, Monoclonal Phase 1
13 Antirheumatic Agents Phase 1
14 Immunoglobulins Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-Label Study to Evaluate Efficacy and Safety of SCY-078 in Patients With Refractory or Intolerant Fungal Diseases Recruiting NCT03059992 Phase 3 SCY-078
2 CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis Recruiting NCT02629419 Phase 2 Amphotericin B
3 Rituximab for Anti-cytokine Autoantibody-Associated Diseases Recruiting NCT01842386 Phase 1 Rituximab/Rituxan
4 Studies of Disorders With Increased Susceptibility to Fungal Infections Recruiting NCT01222741

Search NIH Clinical Center for Chronic Mucocutaneous Candidiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: candidiasis, chronic mucocutaneous

Genetic Tests for Chronic Mucocutaneous Candidiasis

Genetic tests related to Chronic Mucocutaneous Candidiasis:

# Genetic test Affiliating Genes
1 Chronic Mucocutaneous Candidiasis 29

Anatomical Context for Chronic Mucocutaneous Candidiasis

The Foundational Model of Anatomy Ontology organs/tissues related to Chronic Mucocutaneous Candidiasis:

19
Skin, Mucous Membrane, Nail Due To T-Cell Defects

MalaCards organs/tissues related to Chronic Mucocutaneous Candidiasis:

41
Skin, T Cells, Eye, Neutrophil, Bone Marrow, Monocytes, Lung

Publications for Chronic Mucocutaneous Candidiasis

Articles related to Chronic Mucocutaneous Candidiasis:

(show top 50) (show all 270)
# Title Authors Year
1
Chronic mucocutaneous candidiasis due to gain-of-function mutation in STAT1. ( 29702748 )
2018
2
Chronic mucocutaneous candidiasis, a case study and literature review. ( 29500032 )
2018
3
Utility of Ruxolitinib in a Child with Chronic Mucocutaneous Candidiasis Caused by a Novel STAT1 Gain-of-Function Mutation. ( 29934865 )
2018
4
A Novel Heterozygous Mutation in the STAT1 SH2 Domain Causes Chronic Mucocutaneous Candidiasis, Atypically Diverse Infections, Autoimmunity, and Impaired Cytokine Regulation. ( 28348565 )
2017
5
A gain-of-function mutation of STAT1: A novel genetic factor contributing to chronic mucocutaneous candidiasis. ( 28597685 )
2017
6
Chronic mucocutaneous candidiasis: what can we conclude about IL-17 antagonism? ( 29076381 )
2017
7
CMCD: Chronic Mucocutaneous Candidiasis Disease. ( 28603201 )
2017
8
Vessel wall MRI revealing inflammation on brain aneurysm associated to chronic mucocutaneous candidiasis. ( 28992729 )
2017
9
New and recurrent STAT1 mutations in seven Chinese patients with chronic mucocutaneous candidiasis. ( 27808400 )
2017
10
Disseminated Tuberculosis and Chronic Mucocutaneous Candidiasis in a Patient with a Gain-of-Function Mutation in Signal Transduction and Activator of Transcription 1. ( 29270166 )
2017
11
Gain-of-Function Mutations in<i>STAT1</i>: A Recently Defined Cause for Chronic Mucocutaneous Candidiasis Disease Mimicking Combined Immunodeficiencies. ( 29259832 )
2017
12
Chronic Mucocutaneous Candidiasis. ( 28065688 )
2017
13
Th2 and Th9 responses in patients with chronic mucocutaneous candidiasis and hyper-IgE syndrome. ( 27474157 )
2016
14
The Extended Clinical Phenotype of 26 Patients with Chronic Mucocutaneous Candidiasis due to Gain-of-Function Mutations in STAT1. ( 26604104 )
2016
15
Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility. ( 26621323 )
2016
16
Chronic mucocutaneous candidiasis associated with an SH2 domain gain-of-function mutation that enhances STAT1 phosphorylation. ( 26948078 )
2016
17
Clinical and immunological data of nine patients with chronic mucocutaneous candidiasis disease. ( 26981552 )
2016
18
Clinical heterogeneity of dominant chronic mucocutaneous candidiasis disease: presenting as treatment-resistant candidiasis and chronic lung disease. ( 26732859 )
2016
19
Treatment options for chronic mucocutaneous candidiasis. ( 27161991 )
2016
20
Chronic mucocutaneous candidiasis presenting as Candida endophthalmitis. ( 27085277 )
2016
21
Ruxolitinib Induces Interleukin 17 and Ameliorates Chronic Mucocutaneous Candidiasis Caused by STAT1 Gain-of-Function Mutation. ( 26787170 )
2016
22
Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients. ( 26849050 )
2016
23
Chronic mucocutaneous candidiasis disease associated with inborn errors of IL-17 immunity. ( 28090315 )
2016
24
A novel gain-of-function STAT1 mutation resulting in basal phosphorylation of STAT1 and increased distal IFN-I^-mediated responses in chronic mucocutaneous candidiasis. ( 26514428 )
2015
25
Use of ruxolitinib to successfully treat chronic mucocutaneous candidiasis caused by gain-of-function signal transducer and activator of transcription 1 (STAT1) mutation. ( 25662309 )
2015
26
Immunotherapy with G-CSF in patients with chronic mucocutaneous candidiasis. ( 25999307 )
2015
27
A STAT1-gain-of-function mutation causing Th17 deficiency with chronic mucocutaneous candidiasis, psoriasiform hyperkeratosis and dermatophytosis. ( 26494717 )
2015
28
Recurrent inflammatory aortic aneurysms in chronic mucocutaneous candidiasis with a gain-of-function STAT1 mutation. ( 26080282 )
2015
29
Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). ( 26255980 )
2015
30
Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. ( 25918342 )
2015
31
Altered immune responses in patients with chronic mucocutaneous candidiasis. ( 24582143 )
2014
32
Two Novel Gain-of-Function Mutations of STAT1 Responsible for Chronic Mucocutaneous Candidiasis Disease: Impaired Production of IL-17A and IL-22, and the Presence of Anti-IL-17F Autoantibody. ( 25288569 )
2014
33
Chronic mucocutaneous candidiasis: a case with exuberant cutaneous horns in nipples. ( 25054753 )
2014
34
Gain-of-function mutations in signal transducer and activator of transcription 1 (STAT1): Chronic mucocutaneous candidiasis accompanied by enamel defects and delayed dental shedding. ( 25042743 )
2014
35
Simple diagnosis of STAT1 gain-of-function alleles in patients with chronic mucocutaneous candidiasis. ( 24343863 )
2013
36
Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. ( 24240291 )
2013
37
IL-17 T Cells' Defective Differentiation In Vitro Despite Normal Range Ex Vivo in Chronic Mucocutaneous Candidiasis Due to STAT1 Mutation. ( 24335902 )
2013
38
Autoimmunity and cystatin SA1 deficiency behind chronic mucocutaneous candidiasis in autoimmune polyendocrine syndrome type 1. ( 23122533 )
2013
39
Continuous G-CSF therapy for isolated chronic mucocutaneous candidiasis: complete clinical remission with restoration of IL-17 secretion. ( 23791509 )
2013
40
An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. ( 24120361 )
2013
41
New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe. ( 23709754 )
2013
42
Autosomal dominant cases of chronic mucocutaneous candidiasis segregates with mutations of signal transducer and activator of transcription 1, but not of Toll-like receptor 3. ( 23541088 )
2013
43
Chronic mucocutaneous candidiasis and systemic lupus erythematosus: a new variant of chronic mucocutaneous candidiasis? ( 21988702 )
2012
44
Fungal granuloma of the brain in a case of chronic mucocutaneous candidiasis. ( 22724885 )
2012
45
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain. ( 22730530 )
2012
46
Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis. ( 23026768 )
2012
47
Autosomal-dominant chronic mucocutaneous candidiasis with STAT1-mutation can be complicated with chronic active hepatitis and hypothyroidism. ( 22847544 )
2012
48
Photo quiz. A 32-year-old man with ulcerative mucositis, skin lesions, and nail dystrophy. Chronic mucocutaneous candidiasis by multidrug-resistant Candida albicans. ( 22403094 )
2012
49
Defects in interleukin-17 immunity in the pathogenesis of chronic mucocutaneous candidiasis. ( 21766202 )
2011
50
STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis. ( 22195034 )
2011

Variations for Chronic Mucocutaneous Candidiasis

Expression for Chronic Mucocutaneous Candidiasis

Search GEO for disease gene expression data for Chronic Mucocutaneous Candidiasis.

Pathways for Chronic Mucocutaneous Candidiasis

Pathways related to Chronic Mucocutaneous Candidiasis according to KEGG:

37
# Name Kegg Source Accession
1 NOD-like receptor signaling pathway hsa04621
2 Phagosome hsa04145
3 Cytokine-cytokine receptor interaction hsa04060
4 Chemokine signaling pathway hsa04062
5 Toll-like receptor signaling pathway hsa04620
6 Jak-STAT signaling pathway hsa04630

Pathways related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CARD9 CLEC7A HSP90AA1 IFNG IL10 IL17A
2
Show member pathways
13.88 IL10 IL17A IL17RA IL17RC IL22 IL23A
3
Show member pathways
13.71 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
4
Show member pathways
13.54 IFNG IL10 IL17A IL17RC IL22 IL23A
5
Show member pathways
13.48 HSP90AA1 IL10 IL17A IL17RA IL17RC IL22
6
Show member pathways
13.35 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
7
Show member pathways
13.34 IL10 IL17A IL17RA IL17RC IL22 IL23A
8
Show member pathways
13.03 CARD9 HSP90AA1 IFNG IL10 IL6 STAT1
9
Show member pathways
12.94 HSP90AA1 IFNG IL10 IL17A IL22 IL2RA
10 12.9 HSP90AA1 IFNG IL23A IL23R IL2RA IL6
11
Show member pathways
12.8 IFNG IL2RA IL6 STAT1 STAT3
12
Show member pathways
12.73 IFNG IL10 IL17A IL22 IL23A IL23R
13
Show member pathways
12.66 IFNG IL10 IL17A IL17F IL23A IL23R
14 12.65 CARD9 IFNG IL10 IL17A IL2RA STAT1
15
Show member pathways
12.42 IFNG IL10 IL17A IL6
16
Show member pathways
12.35 HSP90AA1 IFNG IL17A IL17F IL17RA IL17RB
17 12.34 CARD9 CLEC7A IFNG IL10 IL23A IL6
18
Show member pathways
12.32 IFNG IL6 STAT1 STAT3
19
Show member pathways
12.3 CARD9 CLEC7A IL10 IL23A IL6 STAT1
20
Show member pathways
12.27 IFNG IL10 STAT1 STAT3
21
Show member pathways
12.23 HSP90AA1 IFNG STAT1 STAT3
22
Show member pathways
12.23 IFNG IL10 IL17A IL17F IL22 IL23A
23 12.21 IFNG IL6 STAT1 STAT3
24
Show member pathways
12.2 IL22 IL2RA STAT1 STAT3
25
Show member pathways
12.17 IFNG IL10 IL17A IL17RC IL22 IL23A
26
Show member pathways
12.16 HSP90AA1 IFNG IL10 IL17A IL17F IL22
27
Show member pathways
12.1 IFNG IL2RA STAT1 STAT3
28
Show member pathways
12.06 HSP90AA1 IL2RA STAT1 STAT3
29 12.02 IFNG IL10 IL2RA IL6
30
Show member pathways
12 IFNG IL2RA STAT1 STAT3
31 12 IFNG IL10 IL23R IL2RA IL6 STAT1
32 11.91 IFNG IL10 IL17A IL17RB IL22 IL23A
33 11.9 IFNG IL6 STAT3
34 11.89 IL6 STAT1 STAT3
35 11.89 IFNG IL17A IL23A IL6
36 11.87 IFNG IL10 IL6
37 11.87 HSP90AA1 IL10 IL17A IL17F IL23A IL23R
38 11.84 HSP90AA1 IFNG IL6 STAT1
39 11.83 IFNG IL10 IL17RA IL23A IL6
40
Show member pathways
11.82 IL6 STAT1 STAT3
41 11.76 IL10 IL23A IL6
42 11.64 IFNG STAT1 STAT3
43 11.61 IFNG IL23A IL6
44 11.59 IL2RA IL6 STAT1 STAT3
45 11.57 HSP90AA1 IFNG IL6
46 11.57 IFNG IL10 IL17RB IL2RA
47 11.55 IL10 IL6 STAT3
48 11.55 IFNG IL10 IL6
49
Show member pathways
11.52 IL2RA STAT1 STAT3
50 11.44 IFNG IL17A IL22 IL23A IL6

GO Terms for Chronic Mucocutaneous Candidiasis

Cellular components related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 HSP90AA1 IFNG IL10 IL17A IL17F IL17RA

Biological processes related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.95 CARD9 IFNG IL23A IL6 STAT1
2 defense response to Gram-negative bacterium GO:0050829 9.87 IL23A IL23R IL6
3 positive regulation of inflammatory response GO:0050729 9.86 IL17RA IL17RB IL23A
4 response to glucocorticoid GO:0051384 9.85 IL10 IL22 IL6
5 inflammatory response GO:0006954 9.85 CLEC7A IL10 IL17A IL17F IL22 IL23A
6 positive regulation of T cell proliferation GO:0042102 9.83 IL23A IL23R IL2RA IL6
7 cellular response to cytokine stimulus GO:0071345 9.82 IL17RA STAT1 STAT3
8 humoral immune response GO:0006959 9.81 AIRE IFNG IL6 TRAF3IP2
9 acute-phase response GO:0006953 9.79 IL22 IL6 STAT3
10 defense response to fungus GO:0050832 9.77 IL17A IL17RA IL17RC
11 positive regulation of activated T cell proliferation GO:0042104 9.77 IL23A IL23R IL2RA
12 positive regulation of interleukin-12 production GO:0032735 9.75 IFNG IL23A IL23R
13 positive regulation of interleukin-6 secretion GO:2000778 9.73 IL17A IL17F IL17RC
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 IFNG IL23A IL23R IL6 STAT3
15 regulation of regulatory T cell differentiation GO:0045589 9.71 IFNG IL2RA
16 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.71 IFNG STAT1
17 interleukin-6-mediated signaling pathway GO:0070102 9.71 IL6 STAT1 STAT3
18 positive regulation of defense response to virus by host GO:0002230 9.71 IL23A IL23R STAT1 TRAF3IP2
19 negative regulation of interleukin-10 production GO:0032693 9.7 IL23A IL23R
20 positive regulation of interleukin-17 production GO:0032740 9.7 IL23A IL23R
21 positive regulation of T cell mediated cytotoxicity GO:0001916 9.7 IL23A IL23R
22 interleukin-27-mediated signaling pathway GO:0070106 9.69 STAT1 STAT3
23 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.69 IL23A IL23R
24 interleukin-35-mediated signaling pathway GO:0070757 9.69 STAT1 STAT3
25 positive regulation of T-helper 1 type immune response GO:0002827 9.68 IL23A IL23R
26 interleukin-21-mediated signaling pathway GO:0038114 9.68 STAT1 STAT3
27 positive regulation of natural killer cell proliferation GO:0032819 9.67 IL23A IL23R
28 response to peptidoglycan GO:0032494 9.67 CARD9 IL6
29 positive regulation of T-helper 17 type immune response GO:2000318 9.67 IL23A IL23R
30 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG IL17A IL23A IL23R
31 positive regulation of interleukin-5 secretion GO:2000664 9.66 IL17RA IL17RB
32 positive regulation of activation of Janus kinase activity GO:0010536 9.66 IL23A IL23R
33 positive regulation of memory T cell differentiation GO:0043382 9.65 IL23A IL23R
34 T-helper 17 cell lineage commitment GO:0072540 9.65 IL6 STAT3
35 positive regulation of interleukin-13 secretion GO:2000667 9.65 IL17RA IL17RB
36 interleukin-23-mediated signaling pathway GO:0038155 9.65 IL23A IL23R STAT3
37 granulocyte chemotaxis GO:0071621 9.64 IL17RA IL17RC
38 regulation of tyrosine phosphorylation of STAT protein GO:0042509 9.63 IL23A IL23R
39 positive regulation of NK T cell activation GO:0051135 9.63 IL23A IL23R
40 positive regulation of T-helper 17 cell lineage commitment GO:2000330 9.62 IL23A IL23R
41 fibroblast activation GO:0072537 9.61 IL17A IL17RA
42 regulation of interleukin-6 biosynthetic process GO:0045408 9.61 CARD9 IL17F
43 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A IL17RA
44 regulation of interleukin-2 biosynthetic process GO:0045076 9.58 CARD9 IL17F
45 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.56 IL17A IL17F IL17RA IL17RC
46 cytokine-mediated signaling pathway GO:0019221 9.36 HSP90AA1 IL10 IL17A IL17F IL22 IL23A
47 interleukin-17-mediated signaling pathway GO:0097400 9.35 IL17A IL17F IL17RA IL17RB IL17RC
48 positive regulation of transcription by RNA polymerase II GO:0045944 10.17 AIRE IL10 IL17A IL17F IL23A IL6
49 immune system process GO:0002376 10.11 CARD9 CLEC7A IL23A IL23R IL2RA
50 immune response GO:0006955 10.04 AIRE IFNG IL10 IL17A IL23A IL2RA

Molecular functions related to Chronic Mucocutaneous Candidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.17 IFNG IL10 IL17A IL17F IL22 IL23A
2 CCR5 chemokine receptor binding GO:0031730 9.16 STAT1 STAT3
3 interleukin-17 receptor activity GO:0030368 9.13 IL17RA IL17RB IL17RC
4 protein binding GO:0005515 10.19 AIRE CARD9 CLEC7A HSP90AA1 IFNG IL10

Sources for Chronic Mucocutaneous Candidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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