Aliases & Classifications for Chronic Myocardial Ischemia

MalaCards integrated aliases for Chronic Myocardial Ischemia:

Name: Chronic Myocardial Ischemia 38 55 73

Summaries for Chronic Myocardial Ischemia

MalaCards based summary : Chronic Myocardial Ischemia is related to angiodysplasia and radiation proctitis. An important gene associated with Chronic Myocardial Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Trimetazidine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Chronic Myocardial Ischemia

Diseases related to Chronic Myocardial Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 angiodysplasia 10.7 FGF2 VEGFA
2 radiation proctitis 10.7 FGF2 VEGFA
3 pancreatic serous cystadenoma 10.6 CHGA VEGFA
4 angiomatous meningioma 10.6 FGF2 VEGFA
5 dupuytren contracture 10.6 FGF2 VEGFA
6 carcinoid syndrome 10.6 CHGA VEGFA
7 lipodermatosclerosis 10.6 ANGPT1 VEGFA
8 juvenile nasopharyngeal angiofibroma 10.6 FGF2 VEGFA
9 ischemia 10.5
10 vascular cancer 10.5 FGF2 VEGFA
11 vitreous detachment 10.5 PLG VEGFA
12 cecum adenocarcinoma 10.5 CHGA FGF2
13 blood group, globoside system 10.5 PLG VEGFA
14 endophthalmitis 10.5 PLG VEGFA
15 retinal vascular occlusion 10.5 PLG VEGFA
16 anterior cranial fossa meningioma 10.5 CHGA PLG
17 hemifacial spasm 10.5 NOS3 VEGFA
18 chronic mountain sickness 10.5 NOS3 VEGFA
19 capillary hemangioma 10.4 TEK VEGFA
20 rubeosis iridis 10.4 PLG VEGFA
21 pericardial effusion 10.4 FGF2 VEGFA
22 epileptic encephalopathy, childhood-onset 10.4 ANGPT1 VEGFA
23 connective tissue cancer 10.4 FGF2 VEGFA
24 cardiovascular organ benign neoplasm 10.4 FGF2 TEK
25 intramuscular hemangioma 10.4 ANGPT1 TEK
26 benign perivascular tumor 10.3 FGF2 TEK
27 degeneration of macula and posterior pole 10.3 PLG VEGFA
28 acute mountain sickness 10.3 NOS3 VEGFA
29 placenta accreta 10.3 ANGPT1 TEK
30 glomangioma 10.3 FGF2 TEK
31 adenosquamous pancreas carcinoma 10.3 ANGPT1 TEK
32 hepatopulmonary syndrome 10.3 NOS3 VEGFA
33 keratitis, hereditary 10.2 FGF2 VEGFA
34 hepatic vascular disease 10.2 NOS3 PLG
35 peripheral artery disease 10.2 NOS3 VEGFA
36 pancreatic ductal carcinoma 10.2 TYMP VEGFA
37 vitreous disease 10.2 FGF2 PLG VEGFA
38 wrinkles 10.1 HGF VEGFA
39 critical limb ischemia 10.1 HGF VEGFA
40 macular degeneration, age-related, 1 10.1 FGF2 PLG VEGFA
41 plague 10.1 PLG TYMP
42 placental insufficiency 10.1 TEK VEGFA
43 hemangioma 10.1 FGF2 TEK VEGFA
44 endotheliitis 10.0
45 pyogenic granuloma 10.0 ANGPT1 TEK VEGFA
46 angiosarcoma 9.9 TEK VEGFA
47 arteries, anomalies of 9.9 NOS3 PLG VEGFA
48 bladder squamous cell carcinoma 9.9 FGF2 HGF
49 gastric ulcer 9.8 FGF2 HGF
50 gastric adenocarcinoma 9.7 CHGA TYMP VEGFA

Comorbidity relations with Chronic Myocardial Ischemia via Phenotypic Disease Network (PDN): (show top 50) (show all 131)


Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Angina Pectoris
Anthracosis Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Asbestosis
Atrioventricular Block Atrophic Gastritis
Basilar Artery Insufficiency Benign Essential Hypertension
Bladder Cancer Bronchitis
Bronchopneumonia Cardiac Arrest
Cardiac Arrhythmia Cardiogenic Shock
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Cholecystitis
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Pulmonary Heart Disease Conjunctivitis
Coronary Artery Aneurysm Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Dressler's Syndrome Duodenitis
Dyskinesia of Esophagus Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis

Graphical network of the top 20 diseases related to Chronic Myocardial Ischemia:



Diseases related to Chronic Myocardial Ischemia

Symptoms & Phenotypes for Chronic Myocardial Ischemia

MGI Mouse Phenotypes related to Chronic Myocardial Ischemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 FGF2 VEGFA HGF NOS3 ANGPT1 PLG
2 homeostasis/metabolism MP:0005376 9.97 TEK FGF2 TYMP VEGFA NOS3 ANGPT1
3 growth/size/body region MP:0005378 9.95 CHGA TEK HGF VEGFA NOS3 ANGPT1
4 mortality/aging MP:0010768 9.92 TEK FGF2 HGF VEGFA NOS3 ANGPT1
5 nervous system MP:0003631 9.7 TEK TYMP FGF2 VEGFA NOS3 ANGPT1
6 muscle MP:0005369 9.65 TEK FGF2 VEGFA NOS3 ANGPT1
7 renal/urinary system MP:0005367 9.35 CHGA VEGFA NOS3 ANGPT1 PLG
8 vision/eye MP:0005391 9.1 FGF2 VEGFA NOS3 ANGPT1 PLG TEK

Drugs & Therapeutics for Chronic Myocardial Ischemia

Drugs for Chronic Myocardial Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimetazidine Approved, Investigational Phase 4 5011-34-7
2 Vasodilator Agents Phase 4
3
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
4
Fenofibrate Approved Phase 3 49562-28-9 3339
5 Antimetabolites Phase 3
6 Hypolipidemic Agents Phase 3
7 Lipid Regulating Agents Phase 3
8
Altretamine Approved Phase 2 645-05-6 2123
9 Pharmaceutical Solutions Phase 2,Phase 1
10 Anesthetics Phase 2
11 Adjuvants, Immunologic Phase 2
12
Zinc Approved, Investigational 7440-66-6 23994
13 Angiogenesis Inducing Agents
14 Angiogenesis Inhibitors
15 Angiogenesis Modulating Agents
16 Angiostatins
17 Endostatins 71581480
18 Hormones

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease Completed NCT00282360 Phase 4 Trimetazidine
2 Cell Therapy in Severe Chronic Ischemic Heart Disease Unknown status NCT01727063 Phase 2, Phase 3
3 Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina Completed NCT01508910 Phase 3
4 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment Recruiting NCT03011450 Phase 3 K-877;Fenofibrate;Placebo (for K-877)
5 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function Recruiting NCT03001817 Phase 3 K-877;Fenofibrate;Placebo (for K-877);Placebo (for Fenofibrate)
6 CardiAMP CMI Randomized Controlled Pivotal Trial in Patients With Chronic Myocardial Ischemia and Refractory Angina Not yet recruiting NCT03455725 Phase 3
7 Cell Therapy in Chronic Ischemic Heart Disease Terminated NCT00362388 Phase 3
8 Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery Unknown status NCT01267331 Phase 1, Phase 2
9 MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia (MyStromalCell Trial) Completed NCT01449032 Phase 2
10 Mesenchymal Stem Cells and Myocardial Ischemia Completed NCT01076920 Phase 1, Phase 2
11 Safety & Efficacy of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia (ATHENA II) Completed NCT02052427 Phase 2
12 Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Completed NCT01556022 Phase 2
13 Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction. Completed NCT01454323 Phase 2
14 ACT34-CMI -- Adult Autologous CD34+ Stem Cells Completed NCT00300053 Phase 2
15 Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium Completed NCT00326989 Phase 1, Phase 2
16 Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease Completed NCT00043628 Phase 2
17 Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study) Completed NCT00824005 Phase 2
18 By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy Completed NCT00690209 Phase 2
19 Stem Cell Therapy for Vasculogenesis in Patients With Severe Myocardial Ischemia Completed NCT00260338 Phase 1, Phase 2
20 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy Completed NCT00629018 Phase 2 Bone Marrow Stimulation
21 Administration of Mesenchymal Stem Cells in Patients With Chronic Ischemic Cardiomyopathy (MESAMI2) Recruiting NCT02462330 Phase 2 Autologous MSC from bone marrow;Placebo comparator
22 68 Ga-NODAGA-E[c(RGD╬│K)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease Recruiting NCT03505346 Phase 2 68Ga-NODAGA-E[c(RGDyK)]2
23 Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Recruiting NCT02439541 Phase 1, Phase 2
24 Human Umbilical Cord Stroma MSC in Myocardial Infarction Recruiting NCT02323477 Phase 1, Phase 2
25 Stem Cell Study for Patients With Heart Disease Terminated NCT00221182 Phase 1, Phase 2
26 METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease Terminated NCT01666132 Phase 1, Phase 2
27 Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions Completed NCT00365326 Phase 1
28 Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease Recruiting NCT03043742 Phase 1 Bone Marrow Derived Autologous CD133+ Selected Cell Product
29 Phase I Trial of Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy (RECARDIO Trial) Recruiting NCT02059681 Phase 1
30 Bone Marrow-derived Mesenchymal Stem Cells (MSC) Administration in Weaning From Left Ventricular Assist Device Withdrawn NCT02460770 Phase 1 Autologous mesenchymal stem cells
31 ACT34-CMI -- Adult Autologous CD34+ Stem Cells (Follow-Up Study) Completed NCT00545610
32 Quality of Life in Patients With Chronic Ischemic Heart Disease Completed NCT00005671
33 Evaluation Rehabilitation on Glycometabolic State in Non-Diabetic Coronary Artery Disease (CAD) Patients Completed NCT00917930
34 Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) Completed NCT02159235
35 Increasing the Efficiency of Depression-screening Using Patient-targeted Feedback Completed NCT01879111 Not Applicable
36 Sex and Gender Differences in Ischemic Heart Disease - Endocrine Vascular Disease Approach Recruiting NCT02737982
37 Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis? Recruiting NCT02760394 Not Applicable
38 European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) Recruiting NCT02804789
39 The Microbiome as a Target for Precision Medicine in Atherosclerosis Not yet recruiting NCT03434483
40 Does a Complex Care Discharge Planning Initiative Reduce Unplanned Hospital Readmissions? (G78717-Readmits) Not yet recruiting NCT03256734
41 Bone Marrow Derived Mononuclear Cells for Ischemic Cardiomyopathy Terminated NCT01144221 Not Applicable

Search NIH Clinical Center for Chronic Myocardial Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myocardial Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myocardial Ischemia:
CD34+ stem cells for treatment of congestive heart failure
Embryonic/Adult Cultured Cells Related to Chronic Myocardial Ischemia:
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22163120

Genetic Tests for Chronic Myocardial Ischemia

Anatomical Context for Chronic Myocardial Ischemia

MalaCards organs/tissues related to Chronic Myocardial Ischemia:

41
Heart, Bone, Bone Marrow, Endothelial

Publications for Chronic Myocardial Ischemia

Articles related to Chronic Myocardial Ischemia:

(show all 46)
# Title Authors Year
1
Glycogen synthase kinase 3I^ inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia. ( 29523407 )
2018
2
TI^4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs. ( 29929787 )
2018
3
Chronic Myocardial Ischemia Leads to Loss of Maximal Oxygen Consumption and Complex I Dysfunction. ( 28577850 )
2017
4
Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia. ( 28900462 )
2017
5
Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long-term results. ( 28752630 )
2017
6
Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation. ( 27648122 )
2016
7
Plasma Catestatin: A Useful Biomarker for Coronary Collateral Development with Chronic Myocardial Ischemia. ( 27304618 )
2016
8
Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. ( 28024857 )
2016
9
The Athena Trials: Autologous Adipose-Derived Regenerative Cells (ADRCs) for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction. ( 27148802 )
2016
10
Human Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia. ( 27334487 )
2016
11
Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial. ( 26901787 )
2016
12
Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia. ( 27818233 )
2016
13
Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. ( 25991048 )
2015
14
Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. ( 26478238 )
2015
15
Placental growth factor 2 - A potential therapeutic strategy for chronic myocardial ischemia. ( 26569359 )
2015
16
Induced pluripotent stem cell transplantation in the treatment of porcine chronic myocardial ischemia. ( 25443017 )
2014
17
Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. ( 24481723 )
2014
18
Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. ( 25111309 )
2014
19
Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. ( 25023791 )
2014
20
Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 24051270 )
2013
21
Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics. ( 23212566 )
2013
22
Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. ( 24366099 )
2013
23
Placental growth factor increases regional myocardial blood flow and contractile function in chronic myocardial ischemia. ( 23316060 )
2013
24
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. ( 23628299 )
2013
25
The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs. ( 23997096 )
2013
26
Early use of granulocyte colony stimulating factor improves survival in a rabbit model of chronic myocardial ischemia. ( 23085036 )
2013
27
Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 22982235 )
2012
28
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. ( 23137509 )
2012
29
Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design. ( 22594332 )
2012
30
Quantitative T 2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. ( 22327962 )
2012
31
Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia. ( 24693195 )
2012
32
Bone marrow cell injection for chronic myocardial ischemia: the past and the future. ( 21213093 )
2011
33
Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. ( 21703533 )
2011
34
Early detection of chronic myocardial ischemia in a patient implanted with an ICD capable of intracardiac electrogram monitoring. ( 22147404 )
2011
35
Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. ( 21209073 )
2011
36
Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia. ( 21305250 )
2011
37
Treatment of chronical myocardial ischemia by adenovirus-mediated hepatocyte growth factor gene transfer in minipigs. ( 18488174 )
2008
38
Functional, cellular, and molecular characterization of the angiogenic response to chronic myocardial ischemia in diabetes. ( 17846323 )
2007
39
Angiopoietin-1 promotes functional neovascularization that relieves ischemia by improving regional reperfusion in a swine chronic myocardial ischemia model. ( 16547766 )
2006
40
Gene therapy for chronic myocardial ischemia using platelet-derived endothelial cell growth factor in dogs. ( 15374822 )
2005
41
Cardiomyocyte hyperplasia after plasmid-mediated vascular endothelial growth factor gene transfer in pigs with chronic myocardial ischemia. ( 14978775 )
2004
42
Gene therapy in cardiac surgery: intramyocardial injection of naked plasmid DNA for chronic myocardial ischemia. ( 14583313 )
2003
43
Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Kuopio Angiogenesis Trial (KAT). ( 12742981 )
2003
44
Comparison of protein with DNA therapy for chronic myocardial ischemia using fibroblast growth factor-2. ( 12467820 )
2002
45
Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. ( 10640320 )
2000
46
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. ( 10961959 )
2000

Variations for Chronic Myocardial Ischemia

Expression for Chronic Myocardial Ischemia

Search GEO for disease gene expression data for Chronic Myocardial Ischemia.

Pathways for Chronic Myocardial Ischemia

Pathways related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 ANGPT1 CHGA FGF2 HGF NOS3 TEK
2
Show member pathways
13.6 ANGPT1 FGF2 HGF TEK TYMP VEGFA
3
Show member pathways
13.46 FGF2 HGF NOS3 TEK TYMP VEGFA
4
Show member pathways
13.26 ANGPT1 FGF2 HGF TEK VEGFA
5
Show member pathways
13.24 ANGPT1 FGF2 HGF TEK TYMP VEGFA
6
Show member pathways
13.13 ANGPT1 FGF2 HGF NOS3 TEK TYMP
7
Show member pathways
13.1 ANGPT1 FGF2 HGF TEK VEGFA
8
Show member pathways
13.05 ANGPT1 HGF NOS3 PLG TEK VEGFA
9
Show member pathways
13.04 ANGPT1 FGF2 HGF TEK TYMP
10
Show member pathways
12.96 FGF2 HGF NOS3 TEK TYMP VEGFA
11 12.47 ANGPT1 FGF2 HGF TEK VEGFA
12
Show member pathways
12.46 ANGPT1 FGF2 HGF NOS3 TEK VEGFA
13
Show member pathways
12.41 ANGPT1 FGF2 HGF TEK VEGFA
14
Show member pathways
12.25 ANGPT1 FGF2 NOS3 PLG TEK
15 12.08 FGF2 HGF VEGFA
16
Show member pathways
12.01 FGF2 NOS3 VEGFA
17 11.87 FGF2 HGF VEGFA
18
Show member pathways
11.86 ANGPT1 FGF2 HGF TYMP
19 11.79 FGF2 HGF VEGFA
20 11.67 ANGPT1 TEK VEGFA
21 11.56 ANGPT1 NOS3 TEK VEGFA
22 11.39 NOS3 VEGFA
23 11.34 FGF2 PLG VEGFA
24 11.31 FGF2 VEGFA
25 11.31 FGF2 HGF VEGFA
26 11.3 FGF2 HGF NOS3 TEK TYMP
27
Show member pathways
11.27 HGF VEGFA
28 11.26 FGF2 VEGFA
29 11.2 ANGPT1 TEK
30 11.2 ANGPT1 VEGFA
31 11.11 FGF2 PLG
32 11.01 FGF2 VEGFA
33 10.4 ANGPT1 FGF2 NOS3 TEK VEGFA

GO Terms for Chronic Myocardial Ischemia

Cellular components related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ANGPT1 CHGA FGF2 HGF PLG VEGFA
2 extracellular region GO:0005576 9.5 ANGPT1 CHGA FGF2 HGF PLG TEK
3 platelet alpha granule lumen GO:0031093 8.8 HGF PLG VEGFA

Biological processes related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.99 ANGPT1 FGF2 TEK TYMP VEGFA
2 cell differentiation GO:0030154 9.93 ANGPT1 FGF2 TEK TYMP VEGFA
3 negative regulation of apoptotic process GO:0043066 9.9 ANGPT1 HGF TEK VEGFA
4 regulation of signaling receptor activity GO:0010469 9.85 FGF2 HGF TYMP VEGFA
5 cytokine-mediated signaling pathway GO:0019221 9.83 FGF2 HGF VEGFA
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.82 ANGPT1 FGF2 TEK
7 in utero embryonic development GO:0001701 9.79 ANGPT1 NOS3 VEGFA
8 MAPK cascade GO:0000165 9.76 ANGPT1 FGF2 HGF TEK
9 peptidyl-tyrosine phosphorylation GO:0018108 9.75 FGF2 HGF TEK
10 positive regulation of protein phosphorylation GO:0001934 9.74 HGF TEK VEGFA
11 platelet degranulation GO:0002576 9.7 HGF PLG VEGFA
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 ANGPT1 HGF VEGFA
13 positive regulation of endothelial cell proliferation GO:0001938 9.67 FGF2 TEK VEGFA
14 positive regulation of cell adhesion GO:0045785 9.65 ANGPT1 VEGFA
15 positive regulation of cell division GO:0051781 9.65 FGF2 VEGFA
16 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 ANGPT1 TEK
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 ANGPT1 HGF TEK
18 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.64 HGF NOS3
19 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.63 FGF2 VEGFA
20 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.63 FGF2 TEK
21 sprouting angiogenesis GO:0002040 9.62 ANGPT1 TEK
22 positive regulation of protein kinase B signaling GO:0051897 9.62 ANGPT1 FGF2 HGF TEK
23 positive regulation of sprouting angiogenesis GO:1903672 9.61 FGF2 VEGFA
24 positive regulation of focal adhesion assembly GO:0051894 9.61 TEK VEGFA
25 positive regulation of receptor internalization GO:0002092 9.58 ANGPT1 VEGFA
26 positive regulation of endothelial cell migration GO:0010595 9.58 ANGPT1 TEK VEGFA
27 cell migration involved in sprouting angiogenesis GO:0002042 9.56 FGF2 VEGFA
28 positive regulation of blood vessel endothelial cell migration GO:0043536 9.56 ANGPT1 FGF2 NOS3 VEGFA
29 positive regulation of angiogenesis GO:0045766 9.55 FGF2 HGF NOS3 TEK VEGFA
30 glomerulus vasculature development GO:0072012 9.43 ANGPT1 TEK
31 Tie signaling pathway GO:0048014 9.37 ANGPT1 TEK
32 positive chemotaxis GO:0050918 9.26 ANGPT1 FGF2 HGF VEGFA
33 angiogenesis GO:0001525 9.1 ANGPT1 FGF2 NOS3 TEK TYMP VEGFA

Molecular functions related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 FGF2 HGF TYMP VEGFA
2 protein tyrosine kinase activity GO:0004713 9.43 FGF2 HGF TEK
3 chemoattractant activity GO:0042056 9.13 FGF2 HGF VEGFA
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 ANGPT1 FGF2 HGF TEK

Sources for Chronic Myocardial Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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