MCID: CHR413
MIFTS: 41

Chronic Myocardial Ischemia

Aliases & Classifications for Chronic Myocardial Ischemia

MalaCards integrated aliases for Chronic Myocardial Ischemia:

Name: Chronic Myocardial Ischemia 39 56 74

External Ids:

UMLS 74 C0264694

Summaries for Chronic Myocardial Ischemia

MalaCards based summary : Chronic Myocardial Ischemia is related to myocardial infarction and ischemia. An important gene associated with Chronic Myocardial Ischemia is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Trimetazidine and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and bone marrow, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Chronic Myocardial Ischemia

Diseases related to Chronic Myocardial Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 myocardial infarction 29.2 ANGPT1 NOS3 PLG VEGFA
2 ischemia 10.8
3 angiodysplasia 10.3 FGF2 VEGFA
4 radiation proctitis 10.3 FGF2 VEGFA
5 wrinkles 10.3 HGF VEGFA
6 poems syndrome 10.3 FGF2 VEGFA
7 angiomatous meningioma 10.3 FGF2 VEGFA
8 dupuytren contracture 10.3 FGF2 VEGFA
9 pancreatic serous cystadenoma 10.3 CHGA VEGFA
10 juvenile nasopharyngeal angiofibroma 10.3 FGF2 VEGFA
11 carcinoid syndrome 10.2 CHGA VEGFA
12 lipodermatosclerosis 10.2 ANGPT1 VEGFA
13 cecum adenocarcinoma 10.2 CHGA FGF2
14 hemifacial spasm 10.2 NOS3 VEGFA
15 patellar tendinitis 10.2 NOS3 VEGFA
16 vitreous detachment 10.2 PLG VEGFA
17 vascular cancer 10.2 FGF2 VEGFA
18 chronic mountain sickness 10.2 NOS3 VEGFA
19 blood group, globoside system 10.2 PLG VEGFA
20 pericardial effusion 10.2 FGF2 VEGFA
21 gastric ulcer 10.2 FGF2 HGF
22 endophthalmitis 10.2 PLG VEGFA
23 retinal vascular occlusion 10.2 PLG VEGFA
24 breast carcinoma in situ 10.2 FGF2 VEGFA
25 epileptic encephalopathy, childhood-onset 10.2 ANGPT1 VEGFA
26 connective tissue cancer 10.2 FGF2 VEGFA
27 hepatic veno-occlusive disease 10.2 PLG VEGFA
28 anterior cranial fossa meningioma 10.2 CHGA PLG
29 acute mountain sickness 10.2 NOS3 VEGFA
30 vitreoretinopathy, neovascular inflammatory 10.1 FGF2 HGF
31 vein disease 10.1 PLG VEGFA
32 hepatopulmonary syndrome 10.1 NOS3 VEGFA
33 keratitis, hereditary 10.1 FGF2 VEGFA
34 lymphangiosarcoma 10.1 TYMP VEGFA
35 peripheral artery disease 10.1 NOS3 VEGFA
36 pancreatic ductal carcinoma 10.1 TYMP VEGFA
37 myeloma, multiple 10.1 FGF2 HGF VEGFA
38 dry eye syndrome 10.1 FGF2 HGF
39 hepatic vascular disease 10.1 NOS3 PLG
40 vitreous disease 10.0 FGF2 PLG VEGFA
41 capillary hemangioma 10.0 TEK VEGFA
42 macular degeneration, age-related, 1 10.0 FGF2 PLG VEGFA
43 plague 10.0 PLG TYMP
44 angiosarcoma 10.0 TEK VEGFA
45 rere-related disorders 10.0
46 intramuscular hemangioma 10.0 ANGPT1 TEK
47 retinal vascular disease 10.0 PLG VEGFA
48 placenta accreta 9.9 ANGPT1 TEK
49 arteries, anomalies of 9.9 NOS3 PLG VEGFA
50 placental insufficiency 9.9 TEK VEGFA

Comorbidity relations with Chronic Myocardial Ischemia via Phenotypic Disease Network (PDN): (show top 50) (show all 131)


Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Acute Vascular Insufficiency of Intestine Angina Pectoris
Anthracosis Anxiety
Aortic Aneurysm Aortic Atherosclerosis
Aortic Valve Disease 1 Asbestosis
Atrioventricular Block Atrophic Gastritis
Basilar Artery Insufficiency Benign Essential Hypertension
Bladder Cancer Bronchitis
Bronchopneumonia Cardiac Arrest
Cardiac Arrhythmia Cardiogenic Shock
Cerebral Atherosclerosis Cerebral Degeneration
Cerebrovascular Disease Cholecystitis
Chronic Intestinal Vascular Insufficiency Chronic Kidney Failure
Chronic Pulmonary Heart Disease Conjunctivitis
Coronary Artery Aneurysm Cystitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Dressler's Syndrome Duodenitis
Dyskinesia of Esophagus Dysthymic Disorder
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gastroesophageal Reflux
Generalized Anxiety Disorder Generalized Atherosclerosis

Graphical network of the top 20 diseases related to Chronic Myocardial Ischemia:



Diseases related to Chronic Myocardial Ischemia

Symptoms & Phenotypes for Chronic Myocardial Ischemia

MGI Mouse Phenotypes related to Chronic Myocardial Ischemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.03 ANGPT1 CHGA FGF2 HGF NOS3 PLG
2 homeostasis/metabolism MP:0005376 9.97 ANGPT1 CHGA FGF2 NOS3 PLG TEK
3 growth/size/body region MP:0005378 9.95 ANGPT1 CHGA HGF NOS3 PLG TEK
4 mortality/aging MP:0010768 9.92 ANGPT1 CHGA FGF2 HGF NOS3 PLG
5 nervous system MP:0003631 9.76 ANGPT1 CHGA FGF2 NOS3 PLG TEK
6 muscle MP:0005369 9.73 ANGPT1 CHGA FGF2 NOS3 TEK VEGFA
7 renal/urinary system MP:0005367 9.35 ANGPT1 CHGA NOS3 PLG VEGFA
8 vision/eye MP:0005391 9.1 ANGPT1 FGF2 NOS3 PLG TEK VEGFA

Drugs & Therapeutics for Chronic Myocardial Ischemia

Drugs for Chronic Myocardial Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trimetazidine Approved, Investigational Phase 4 5011-34-7
2 Vasodilator Agents Phase 4
3
Sargramostim Approved, Investigational Phase 3,Phase 2 123774-72-1, 83869-56-1
4
Lenograstim Approved, Investigational Phase 3,Phase 2 135968-09-1
5
Fenofibrate Approved Phase 3 49562-28-9 3339
6 Lipid Regulating Agents Phase 3
7 Antimetabolites Phase 3
8 Hypolipidemic Agents Phase 3
9
Altretamine Approved Phase 2 645-05-6 2123
10 Pharmaceutical Solutions Phase 2,Phase 1
11 Anesthetics Phase 2
12 Immunologic Factors Phase 2
13 Adjuvants, Immunologic Phase 2
14
Iron Approved, Experimental Phase 1 7439-89-6, 15438-31-0 23925 27284
15
Zinc Approved, Investigational 7440-66-6 32051
16
Ethanol Approved Not Applicable 64-17-5 702
17 Angiogenesis Inducing Agents
18 Angiostatins
19 Endostatins 71581480
20 Angiogenesis Inhibitors
21 Angiogenesis Modulating Agents
22 Immunoglobulins
23 Hemostatics
24 Antibodies
25 Hormones

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Effect of Metabolic Therapy in Patients With Chronic Ischemic Heart Disease Completed NCT00282360 Phase 4 Trimetazidine
2 Cell Therapy in Severe Chronic Ischemic Heart Disease Unknown status NCT01727063 Phase 2, Phase 3
3 Efficacy and Safety of Targeted Intramyocardial Delivery of Auto CD34+ Stem Cells for Improving Exercise Capacity in Subjects With Refractory Angina Completed NCT01508910 Phase 3
4 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Mild or Moderate Renal Impairment Active, not recruiting NCT03011450 Phase 3 K-877;Fenofibrate;Placebo (for K-877)
5 Study to Evaluate the Efficacy and Safety of K-877 in Adult Patients With Fasting High Triglyceride Levels and Normal Renal Function Active, not recruiting NCT03001817 Phase 3 K-877;Fenofibrate;Placebo (for K-877);Placebo (for Fenofibrate)
6 CardiAMP CMI Randomized Controlled Pivotal Trial in Patients With Chronic Myocardial Ischemia and Refractory Angina Not yet recruiting NCT03455725 Phase 3
7 Cell Therapy in Chronic Ischemic Heart Disease Terminated NCT00362388 Phase 3
8 Cell Therapy in Patients With Chronic Ischemic Heart Disease Undergoing Cardiac Surgery Unknown status NCT01267331 Phase 1, Phase 2
9 Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Ischemic Cardiomyopathy Unknown status NCT02439541 Phase 1, Phase 2
10 Human Umbilical Cord Stroma MSC in Myocardial Infarction Unknown status NCT02323477 Phase 1, Phase 2
11 MesenchYmal STROMAL CELL Therapy in Patients With Chronic Myocardial Ischemia (MyStromalCell Trial) Completed NCT01449032 Phase 2
12 Mesenchymal Stem Cells and Myocardial Ischemia Completed NCT01076920 Phase 1, Phase 2
13 Safety & Efficacy of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia (ATHENA II) Completed NCT02052427 Phase 2
14 Safety and Feasibility Trial of Adipose-Derived Regenerative Cells in the Treatment of Chronic Myocardial Ischemia Completed NCT01556022 Phase 2
15 Intracoronary Infusion of Bone Marrow Mononuclear Cells in Patients With Previous Myocardial Infarction. Completed NCT01454323 Phase 2
16 ACT34-CMI -- Adult Autologous CD34+ Stem Cells Completed NCT00300053 Phase 2
17 Cell-Wave Study: Combined Extracorporal Shock Wave Therapy and Intracoronary Cell Therapy in Chronic Ischemic Myocardium Completed NCT00326989 Phase 1, Phase 2
18 Stem Cell Mobilization to Treat Chest Pain and Shortness of Breath in Patients With Coronary Artery Disease Completed NCT00043628 Phase 2
19 Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study) Completed NCT00824005 Phase 2
20 By Pass Surgery With Stem Cell Therapy in Chronic Ischemic Cardiopathy Completed NCT00690209 Phase 2
21 Stem Cell Therapy for Vasculogenesis in Patients With Severe Myocardial Ischemia Completed NCT00260338 Phase 1, Phase 2
22 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy Completed NCT00629018 Phase 2 Bone Marrow Stimulation
23 Administration of Mesenchymal Stem Cells in Patients With Chronic Ischemic Cardiomyopathy (MESAMI2) Recruiting NCT02462330 Phase 2 Autologous MSC from bone marrow;Placebo comparator
24 68 Ga-NODAGA-E[c(RGD╬│K)]2: Positron Emission Tomography Tracer for Imaging of Angiogenesis in Ischemic Heart Disease Recruiting NCT03505346 Phase 2 68Ga-NODAGA-E[c(RGDyK)]2
25 Stem Cell Study for Patients With Heart Disease Terminated NCT00221182 Phase 1, Phase 2
26 METHOD - Bone Marrow Derived Mononuclear Cells in Chronic Ischemic Disease Terminated NCT01666132 Phase 1, Phase 2
27 In Vivo Tracking of USPIO Labeled MSC in the Heart Completed NCT03651791 Phase 1
28 Safety and Efficacy of Autologous, Intracoronary Stem Cell Injections in Total Coronary Artery Occlusions Completed NCT00365326 Phase 1
29 Stem Cell Heart Injections During Laser Revascularization Surgery for Treatment of Chronic Ischemic Heart Disease Recruiting NCT03043742 Phase 1 Bone Marrow Derived Autologous CD133+ Selected Cell Product
30 Phase I Trial of Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy (RECARDIO Trial) Recruiting NCT02059681 Phase 1
31 Bone Marrow-derived Mesenchymal Stem Cells (MSC) Administration in Weaning From Left Ventricular Assist Device Withdrawn NCT02460770 Phase 1 Autologous mesenchymal stem cells
32 Hyperbaric Oxygen Therapy in Patients With Chronic Stable Ischemic Heart Disease: An Option for Therapeutic Angiogenesis? Unknown status NCT02760394 Not Applicable
33 ACT34-CMI -- Adult Autologous CD34+ Stem Cells (Follow-Up Study) Completed NCT00545610
34 Quality of Life in Patients With Chronic Ischemic Heart Disease Completed NCT00005671
35 Evaluation Rehabilitation on Glycometabolic State in Non-Diabetic Coronary Artery Disease (CAD) Patients Completed NCT00917930
36 Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) Completed NCT02159235
37 STable Coronary Artery Diseases RegisTry Completed NCT03796741
38 Increasing the Efficiency of Depression-screening Using Patient-targeted Feedback Completed NCT01879111 Not Applicable
39 Lifestyle Intervention in Chronic Ischemic Heart Disease and Diabetes Recruiting NCT03835923 Not Applicable
40 Study of Cardiac Lesions Angiogenesis by 68Ga-NODAGA-RGD Cardiac PET Recruiting NCT03809689 Not Applicable
41 The Microbiome as a Target for Precision Medicine in Atherosclerosis Recruiting NCT03434483
42 Sex and Gender Differences in Ischemic Heart Disease - Endocrine Vascular Disease Approach Recruiting NCT02737982
43 Does a Complex Care Discharge Planning Initiative Reduce Unplanned Hospital Readmissions? (G78717-Readmits) Recruiting NCT03256734
44 European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) Recruiting NCT02804789
45 Bone Marrow Derived Mononuclear Cells for Ischemic Cardiomyopathy Terminated NCT01144221 Not Applicable

Search NIH Clinical Center for Chronic Myocardial Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Myocardial Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Myocardial Ischemia:
CD34+ stem cells for treatment of congestive heart failure
Embryonic/Adult Cultured Cells Related to Chronic Myocardial Ischemia:
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22163120

Genetic Tests for Chronic Myocardial Ischemia

Anatomical Context for Chronic Myocardial Ischemia

MalaCards organs/tissues related to Chronic Myocardial Ischemia:

42
Heart, Bone, Bone Marrow, Endothelial

Publications for Chronic Myocardial Ischemia

Articles related to Chronic Myocardial Ischemia:

(show top 50) (show all 102)
# Title Authors Year
1
Glycogen synthase kinase 3I^ inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia. ( 29523407 )
2018
2
TI^4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs. ( 29929787 )
2018
3
Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. ( 30226574 )
2018
4
Chronic Myocardial Ischemia Leads to Loss of Maximal Oxygen Consumption and Complex I Dysfunction. ( 28577850 )
2017
5
Comparison of the Therapeutic Effects of Acupuncture at PC6 and ST36 for Chronic Myocardial Ischemia. ( 28900462 )
2017
6
Safety and efficacy of percutaneous intramyocardial bone marrow cell injection for chronic myocardial ischemia: Long-term results. ( 28752630 )
2017
7
Vitexin exerts cardioprotective effect on chronic myocardial ischemia/reperfusion injury in rats via inhibiting myocardial apoptosis and lipid peroxidation. ( 27648122 )
2016
8
Plasma Catestatin: A Useful Biomarker for Coronary Collateral Development with Chronic Myocardial Ischemia. ( 27304618 )
2016
9
Calpain inhibition decreases inflammatory protein expression in vessel walls in a model of chronic myocardial ischemia. ( 28024857 )
2016
10
The Athena Trials: Autologous Adipose-Derived Regenerative Cells (ADRCs) for Refractory Chronic Myocardial Ischemia with Left Ventricular Dysfunction. ( 27148802 )
2016
11
Human Umbilical Cord-Derived Mesenchymal Stromal Cells Improve Left Ventricular Function, Perfusion, and Remodeling in a Porcine Model of Chronic Myocardial Ischemia. ( 27334487 )
2016
12
Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of the MESAMI 1 pilot trial. ( 26901787 )
2016
13
Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia. ( 27818233 )
2016
14
Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia. ( 25991048 )
2015
15
Calpain inhibition improves collateral-dependent perfusion in a hypercholesterolemic swine model of chronic myocardial ischemia. ( 26478238 )
2015
16
Placental growth factor 2 - A potential therapeutic strategy for chronic myocardial ischemia. ( 26569359 )
2015
17
Induced pluripotent stem cell transplantation in the treatment of porcine chronic myocardial ischemia. ( 25443017 )
2014
18
Effect of intramyocardial bone marrow-derived mononuclear cell injection on cardiac sympathetic innervation in patients with chronic myocardial ischemia. ( 24481723 )
2014
19
Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. ( 25111309 )
2014
20
Predictors of response to intramyocardial bone marrow cell treatment in patients with refractory angina and chronic myocardial ischemia. ( 25023791 )
2014
21
Local infiltration of neuropeptide Y as a potential therapeutic agent against apoptosis and fibrosis in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 24051270 )
2013
22
Energy metabolism disorder and myocardial injury in chronic myocardial ischemia with Qi deficiency and blood stasis syndrome based on 2-DE proteomics. ( 23212566 )
2013
23
Microvascular Notch Signaling Is Upregulated in Response to Vascular Endothelial Growth Factor and Chronic Myocardial Ischemia. ( 24366099 )
2013
24
Placental growth factor increases regional myocardial blood flow and contractile function in chronic myocardial ischemia. ( 23316060 )
2013
25
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemia. ( 23628299 )
2013
26
The bottleneck stent model for chronic myocardial ischemia and heart failure in pigs. ( 23997096 )
2013
27
Early use of granulocyte colony stimulating factor improves survival in a rabbit model of chronic myocardial ischemia. ( 23085036 )
2013
28
Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 22982235 )
2012
29
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparison. ( 23137509 )
2012
30
Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design. ( 22594332 )
2012
31
Quantitative T 2* assessment of acute and chronic myocardial ischemia/reperfusion injury in mice. ( 22327962 )
2012
32
Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia. ( 24693195 )
2012
33
Bone marrow cell injection for chronic myocardial ischemia: the past and the future. ( 21213093 )
2011
34
Human hepatocyte growth factor (VM202) gene therapy via transendocardial injection in a pig model of chronic myocardial ischemia. ( 21703533 )
2011
35
Early detection of chronic myocardial ischemia in a patient implanted with an ICD capable of intracardiac electrogram monitoring. ( 22147404 )
2011
36
Intramyocardial bone marrow-derived mononuclear cell injection for chronic myocardial ischemia: the effect on diastolic function. ( 21209073 )
2011
37
Involvement of endoplasmic reticulum stress-associated apoptosis in a heart failure model induced by chronic myocardial ischemia. ( 21305250 )
2011
38
Echocardiographic analysis with a two-dimensional strain of chronic myocardial ischemia induced with ameroid constrictor in the pig. ( 20139196 )
2010
39
Local transient myocardial liposomal gene transfer of inducible nitric oxide synthase does not aggravate myocardial function and fibrosis and leads to moderate neovascularization in chronic myocardial ischemia in pigs. ( 20141602 )
2010
40
Aquaporin-1 expression and angiogenesis in rabbit chronic myocardial ischemia is decreased by acetazolamide. ( 20512452 )
2010
41
Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia. ( 20729101 )
2010
42
Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia. ( 20826160 )
2010
43
Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. ( 20837905 )
2010
44
Hiccups as a sign of chronic myocardial ischemia. ( 20859249 )
2010
45
Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology. ( 19077390 )
2009
46
Autologous transplantation of EPCs encoding FGF1 gene promotes neovascularization in a porcine model of chronic myocardial ischemia. ( 19181401 )
2009
47
Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trial. ( 19454638 )
2009
48
Effect of intramyocardial bone marrow cell injection on diastolic function in patients with chronic myocardial ischemia. ( 18425845 )
2008
49
Therapeutic potential of adult progenitor cells in the management of chronic myocardial ischemia. ( 18828643 )
2008
50
Acute versus chronic myocardial ischemia: a differential biological profile study. ( 19127089 )
2008

Variations for Chronic Myocardial Ischemia

Expression for Chronic Myocardial Ischemia

Search GEO for disease gene expression data for Chronic Myocardial Ischemia.

Pathways for Chronic Myocardial Ischemia

Pathways related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 ANGPT1 CHGA FGF2 HGF NOS3 TEK
2
Show member pathways
13.62 ANGPT1 FGF2 HGF TEK TYMP VEGFA
3
Show member pathways
13.47 FGF2 HGF NOS3 TEK TYMP VEGFA
4
Show member pathways
13.33 FGF2 HGF NOS3 TEK TYMP
5
Show member pathways
13.28 ANGPT1 FGF2 HGF TEK TYMP VEGFA
6
Show member pathways
13.27 ANGPT1 FGF2 HGF TEK VEGFA
7
Show member pathways
13.15 ANGPT1 FGF2 HGF NOS3 TEK TYMP
8
Show member pathways
13.11 ANGPT1 FGF2 HGF TEK VEGFA
9
Show member pathways
13.07 ANGPT1 HGF NOS3 PLG TEK VEGFA
10
Show member pathways
13.05 ANGPT1 FGF2 HGF TEK TYMP
11
Show member pathways
12.96 FGF2 HGF NOS3 TEK TYMP VEGFA
12
Show member pathways
12.57 ANGPT1 FGF2 HGF NOS3 TEK VEGFA
13 12.47 ANGPT1 FGF2 HGF TEK VEGFA
14
Show member pathways
12.41 ANGPT1 FGF2 HGF TEK VEGFA
15
Show member pathways
12.25 ANGPT1 FGF2 NOS3 PLG TEK
16
Show member pathways
12.18 FGF2 HGF TEK TYMP
17 12.1 FGF2 HGF VEGFA
18
Show member pathways
12.03 FGF2 NOS3 VEGFA
19 11.88 FGF2 HGF VEGFA
20
Show member pathways
11.86 ANGPT1 FGF2 HGF TYMP
21 11.79 FGF2 HGF VEGFA
22 11.67 ANGPT1 TEK VEGFA
23 11.53 FGF2 HGF TYMP
24 11.46 ANGPT1 NOS3 TEK VEGFA
25 11.4 NOS3 VEGFA
26 11.36 FGF2 PLG VEGFA
27 11.33 FGF2 HGF VEGFA
28 11.32 FGF2 VEGFA
29 11.3 FGF2 HGF NOS3 TEK TYMP
30
Show member pathways
11.28 HGF VEGFA
31 11.28 FGF2 VEGFA
32 11.21 ANGPT1 TEK
33 11.21 ANGPT1 VEGFA
34 11.12 FGF2 PLG
35 11.03 FGF2 VEGFA
36 10.76 ANGPT1 FGF2 HGF TEK TYMP
37 10.4 ANGPT1 FGF2 NOS3 TEK VEGFA
38 10.12 ANGPT1 TEK

GO Terms for Chronic Myocardial Ischemia

Cellular components related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 ANGPT1 CHGA FGF2 HGF PLG VEGFA
2 extracellular region GO:0005576 9.5 ANGPT1 CHGA FGF2 HGF PLG TEK
3 platelet alpha granule lumen GO:0031093 8.8 HGF PLG VEGFA

Biological processes related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 ANGPT1 HGF TEK VEGFA
2 regulation of signaling receptor activity GO:0010469 9.86 FGF2 HGF TYMP VEGFA
3 cell differentiation GO:0030154 9.84 ANGPT1 FGF2 TYMP VEGFA
4 cytokine-mediated signaling pathway GO:0019221 9.83 FGF2 HGF VEGFA
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.82 ANGPT1 FGF2 TEK
6 in utero embryonic development GO:0001701 9.79 ANGPT1 NOS3 VEGFA
7 positive regulation of protein phosphorylation GO:0001934 9.77 HGF TEK VEGFA
8 peptidyl-tyrosine phosphorylation GO:0018108 9.76 FGF2 HGF TEK
9 MAPK cascade GO:0000165 9.76 ANGPT1 FGF2 HGF TEK
10 platelet degranulation GO:0002576 9.72 HGF PLG VEGFA
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 ANGPT1 HGF VEGFA
12 positive regulation of endothelial cell proliferation GO:0001938 9.69 FGF2 TEK VEGFA
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 ANGPT1 HGF TEK
14 positive regulation of protein kinase B signaling GO:0051897 9.67 ANGPT1 FGF2 HGF TEK
15 positive regulation of cell adhesion GO:0045785 9.66 ANGPT1 VEGFA
16 positive regulation of cell division GO:0051781 9.65 FGF2 VEGFA
17 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.65 FGF2 VEGFA
18 negative regulation of endothelial cell apoptotic process GO:2000352 9.64 ANGPT1 TEK
19 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.63 HGF NOS3
20 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.63 FGF2 TEK
21 positive regulation of sprouting angiogenesis GO:1903672 9.62 FGF2 VEGFA
22 positive regulation of focal adhesion assembly GO:0051894 9.61 TEK VEGFA
23 positive regulation of endothelial cell migration GO:0010595 9.61 ANGPT1 TEK VEGFA
24 positive regulation of receptor internalization GO:0002092 9.59 ANGPT1 VEGFA
25 cell migration involved in sprouting angiogenesis GO:0002042 9.58 FGF2 VEGFA
26 positive regulation of DNA biosynthetic process GO:2000573 9.57 FGF2 HGF
27 positive regulation of blood vessel endothelial cell migration GO:0043536 9.56 ANGPT1 FGF2 NOS3 VEGFA
28 sprouting angiogenesis GO:0002040 9.5 ANGPT1 TEK VEGFA
29 glomerulus vasculature development GO:0072012 9.48 ANGPT1 TEK
30 positive chemotaxis GO:0050918 9.46 ANGPT1 FGF2 HGF VEGFA
31 Tie signaling pathway GO:0048014 9.4 ANGPT1 TEK
32 positive regulation of angiogenesis GO:0045766 9.35 FGF2 HGF NOS3 TEK VEGFA
33 angiogenesis GO:0001525 9.1 ANGPT1 FGF2 NOS3 TEK TYMP VEGFA

Molecular functions related to Chronic Myocardial Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.43 FGF2 HGF TEK
2 chemoattractant activity GO:0042056 9.33 FGF2 HGF VEGFA
3 growth factor activity GO:0008083 9.26 FGF2 HGF TYMP VEGFA
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 ANGPT1 FGF2 HGF TEK

Sources for Chronic Myocardial Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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