MCID: CHR068
MIFTS: 24

Chronic Nk-Cell Lymphocytosis

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

MalaCards integrated aliases for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 15
Chronic Lymphoproliferative Disorder of Nk-Cells 71
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 50 C39591
SNOMED-CT 67 722955006
UMLS 71 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

Disease Ontology : 12 A hypersensitivity reaction type IV disease that is characterized by absolute lymphocytosis of natural killer (CD3- CD16+) cells often with concurrent cytopenia and has symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy.

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to aggressive nk-cell leukemia and chronic lymphoproliferative disorder of natural killer cells, and has symptoms including fever An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and Immune response Role of DAP12 receptors in NK cells. Affiliated tissues include nk cells.

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 aggressive nk-cell leukemia 29.2 NCAM1 KLRD1 FCGR3B FCGR3A CD7 B3GAT1
2 chronic lymphoproliferative disorder of natural killer cells 11.4
3 glomangiomatosis 10.2 NCAM1 B3GAT1
4 microscopic polyangiitis 10.2 FCGR3B FCGR3A
5 breast neuroendocrine neoplasm 10.2 NCAM1 B3GAT1
6 transient neonatal neutropenia 10.2 FCGR3B FCGR3A
7 oxirane allergy 10.2 FCGR3B FCGR3A
8 herpetic whitlow 10.1 FCGR3B FCGR3A
9 ceftazidime allergy 10.1 KLRD1 IL15
10 immunodeficiency 20 10.1 FCGR3B FCGR3A
11 immunodeficiency 63 with lymphoproliferation and autoimmunity 10.1 IL15 B3GAT1
12 anauxetic dysplasia 1 10.1 FCGR3B FCGR3A
13 t-cell large granular lymphocyte leukemia 10.1 NCAM1 KLRD1 B3GAT1
14 trichothiodystrophy 5, nonphotosensitive 10.1 FCGR3B FCGR3A
15 lethal midline granuloma 10.1 NCAM1 CD7
16 selective igg deficiency disease 10.0 NCAM1 FCGR3B FCGR3A
17 mosaic variegated aneuploidy syndrome 2 10.0 NCAM1 FCGR3B FCGR3A
18 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 10.0 FCGR3B FCGR3A
19 dermatitis, atopic, 5 10.0 NCAM1 FCGR3B FCGR3A
20 cryptococcosis 10.0 FCGR3B FCGR3A
21 poliomyelitis 9.9 FCGR3B FCGR3A
22 human immunodeficiency virus infectious disease 9.8 NCAM1 IL15 FCGR3A
23 sezary's disease 9.8 NCAM1 IL15 CD7
24 bacterial infectious disease 9.8 IL15 FCGR3B FCGR3A
25 mycosis fungoides 9.8 NCAM1 IL15 CD7
26 behcet syndrome 9.7 IL15 FCGR3B FCGR3A
27 mature t-cell and nk-cell lymphoma 9.7 NCAM1 CD7
28 leukocyte disease 9.7 NCAM1 IL15 FCGR3B FCGR3A
29 trichohepatoenteric syndrome 1 9.7 NCR3 NCR1 KLRD1
30 myeloma, multiple 9.7 NCAM1 IL15 FCGR3B FCGR3A
31 celiac disease 1 9.7 NCAM1 KLRD1 IL15 CD7
32 immunodeficiency 54 9.6 NCR1 NCAM1 KLRD1 IL15 B3GAT1
33 leukemia, chronic lymphocytic 9.5 NCAM1 MIR30C1 FCGR3B FCGR3A CD7
34 lymphoma, non-hodgkin, familial 9.4 NCAM1 MIR30C1 IL15 FCGR3A CD7
35 nk cell deficiency 8.9 NCR3 NCR1 NCAM1 KLRD1 IL15 FCGR3B
36 leukemia, acute myeloid 8.4 NCR3 NCR1 NCAM1 MIR30C1 KLRD1 IL15

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

Symptoms:

12
  • fever

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Search Clinical Trials , NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

40
Nk Cells

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

(show all 13)
# Title Authors PMID Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. 61
26234181 2015
2
Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. 61
20378561 2010
3
Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan. 61
19220421 2009
4
[Analysis of chemokine receptor expression in aggressive NK-cell leukemia and chronic NK-cell lymphocytosis]. 61
18277590 2008
5
Chronic lymphocytosis of functionally immature natural killer cells. 61
17604094 2007
6
Chemokine system and tissue infiltration in aggressive NK-cell leukemia. 61
17123604 2007
7
Significance of chemokine receptor expression in aggressive NK cell leukemia. 61
15902300 2005
8
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. 61
11286541 2001
9
Natural killer cells and the syndrome of chronic natural killer cell lymphocytosis. 61
11378540 2001
10
T-large granular lymphocyte leukemia accompanied by an increase of natural killer cells (CD3-) and associated with ulcerative colitis and autoimmune hepatitis. 61
11342376 2001
11
Chronic lymphatic leukemias of T and NK cell type. 61
9178839 1997
12
Chronic natural killer cell lymphocytosis. 61
8624463 1996
13
Demonstration of clonality, by X-linked DNA analysis, in chronic natural killer cell lymphocytosis and successful therapy with oral cyclophosphamide. 61
1350651 1992

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.02 NCR3 NCR1 KLRD1 FCGR3B FCGR3A

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.5 KLRD1 FCGR3B FCGR3A
2 immune response GO:0006955 9.35 NCR3 IL15 FCGR3B FCGR3A CD7
3 positive regulation of natural killer cell mediated cytotoxicity GO:0045954 9.26 NCR3 KLRD1
4 natural killer cell activation GO:0030101 9.16 NCR3 NCR1
5 regulation of immune response GO:0050776 9.02 NCR3 NCR1 KLRD1 FCGR3B FCGR3A

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.13 KLRD1 FCGR3B FCGR3A
2 IgG binding GO:0019864 8.62 FCGR3B FCGR3A

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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