MCID: CHR068
MIFTS: 25

Chronic Nk-Cell Lymphocytosis

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

MalaCards integrated aliases for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 15
Chronic Lymphoproliferative Disorder of Nk-Cells 71
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 49 C39591
UMLS 71 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

Disease Ontology : 12 A hypersensitivity reaction type IV disease that is characterized by absolute lymphocytosis of natural killer (CD3- CD16+) cells often with concurrent cytopenia and has symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy.

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to aggressive nk-cell leukemia and chronic lymphoproliferative disorder of natural killer cells, and has symptoms including fever An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include nk cells, skin and t cells.

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 aggressive nk-cell leukemia 28.5 NCAM1 KLRD1 FCGR3B FCGR3A CD7 B3GAT1
2 chronic lymphoproliferative disorder of natural killer cells 11.7
3 renal adenoma 10.3 NCAM1 B3GAT1
4 glomangiomatosis 10.3 NCAM1 B3GAT1
5 breast neuroendocrine neoplasm 10.3 NCAM1 B3GAT1
6 epithelial predominant wilms' tumor 10.2 NCAM1 B3GAT1
7 transient neonatal neutropenia 10.2 FCGR3B FCGR3A
8 oxirane allergy 10.2 FCGR3B FCGR3A
9 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 10.1 FCGR3B FCGR3A
10 autoimmune disease of blood 10.1 FCGR3B FCGR3A
11 poliomyelitis 10.1 FCGR3B FCGR3A
12 large cell neuroendocrine carcinoma 10.0 NCAM1 B3GAT1
13 cryptococcosis 10.0 FCGR3B FCGR3A
14 benign mesenchymoma 9.9 CD7 B3GAT1
15 small cell carcinoma 9.8 NCAM1 B3GAT1
16 birdshot chorioretinopathy 9.8 KIR3DL1 KIR2DL1
17 myeloid sarcoma 9.7 NCAM1 CD7
18 celiac disease 1 9.6 NCAM1 KLRD1 CD7
19 t-cell large granular lymphocyte leukemia 9.6 NCAM1 KLRD1 KIR2DL3 KIR2DL1
20 myeloma, multiple 9.5 NCAM1 KIR2DL1 FCGR3B FCGR3A
21 vogt-koyanagi-harada disease 9.5 KIR3DL1 KIR2DL1
22 alzheimer disease 12 9.5 NCAM1 KLRD1 CD7 B3GAT1
23 cd3zeta deficiency 9.4 NCR1 NCAM1 KLRD1 FCGR3B FCGR3A
24 human immunodeficiency virus infectious disease 9.4 NCAM1 KIR3DL1 KIR2DL3 FCGR3A
25 psoriasis 9.3 KLRD1 KIR3DL1 KIR2DL3 FCGR3A
26 spondyloarthropathy 9.3 KIR3DL1 KIR2DL3 KIR2DL1 FCGR3A
27 leukemia, chronic lymphocytic 9.1 NCAM1 FCGR3B FCGR3A CD7 B3GAT1
28 hematologic cancer 9.0 NCAM1 MIR30C1 KIR3DL1 CD7
29 leukemia, acute myeloid 7.2 NCR1 NCAM1 MIR30C1 KLRD1 KIR3DL1 KIR2DL3

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

Symptoms:

12
  • fever

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Search Clinical Trials , NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

40
Nk Cells, Skin, T Cells, Myeloid, Breast

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

(show all 13)
# Title Authors PMID Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. 61
26234181 2015
2
Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. 61
20378561 2010
3
Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan. 61
19220421 2009
4
[Analysis of chemokine receptor expression in aggressive NK-cell leukemia and chronic NK-cell lymphocytosis]. 61
18277590 2008
5
Chronic lymphocytosis of functionally immature natural killer cells. 61
17604094 2007
6
Chemokine system and tissue infiltration in aggressive NK-cell leukemia. 61
17123604 2007
7
Significance of chemokine receptor expression in aggressive NK cell leukemia. 61
15902300 2005
8
Natural killer cells and the syndrome of chronic natural killer cell lymphocytosis. 61
11378540 2001
9
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. 61
11286541 2001
10
T-large granular lymphocyte leukemia accompanied by an increase of natural killer cells (CD3-) and associated with ulcerative colitis and autoimmune hepatitis. 61
11342376 2001
11
Chronic lymphatic leukemias of T and NK cell type. 61
9178839 1997
12
Chronic natural killer cell lymphocytosis. 61
8624463 1996
13
Demonstration of clonality, by X-linked DNA analysis, in chronic natural killer cell lymphocytosis and successful therapy with oral cyclophosphamide. 61
1350651 1992

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.85 NCR1 NCAM1 KLRD1 KIR3DL1 KIR2DL3 KIR2DL1
2 plasma membrane GO:0005886 9.61 NCR1 NCAM1 KLRD1 KIR3DL1 KIR2DL3 KIR2DL1
3 integral component of membrane GO:0016021 9.32 NCR1 NCAM1 KLRD1 KIR3DL1 KIR2DL3 KIR2DL1

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.43 KIR3DL1 KIR2DL3 KIR2DL1 FCGR3B FCGR3A CD7
2 regulation of immune response GO:0050776 9.1 NCR1 KLRD1 KIR3DL1 KIR2DL3 KIR2DL1 FCGR3A

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.13 KIR2DL3 KIR2DL1 CD7
2 IgG binding GO:0019864 8.62 FCGR3B FCGR3A

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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