MCID: CHR068
MIFTS: 31

Chronic Nk-Cell Lymphocytosis

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

MalaCards integrated aliases for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 15
Chronic Lymphoproliferative Disorder of Nk-Cells 72
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 50 C39591
UMLS 72 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

Disease Ontology : 12 A hypersensitivity reaction type IV disease that is characterized by absolute lymphocytosis of natural killer (CD3- CD16+) cells often with concurrent cytopenia and has symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy.

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to natural killer cell leukemia and chronic lymphoproliferative disorder of natural killer cells, and has symptoms including fever An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include nk cells, skin and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 natural killer cell leukemia 30.8 NCAM1 CD2 B3GAT1
2 chronic lymphoproliferative disorder of natural killer cells 11.7
3 transient neonatal neutropenia 10.7 FCGR3B FCGR3A
4 renal adenoma 10.6 NCAM1 B3GAT1
5 epithelial predominant wilms' tumor 10.6 NCAM1 B3GAT1
6 lethal midline granuloma 10.6 NCAM1 CD2
7 lymphocytic gastritis 10.6 FASLG B3GAT1
8 pericoronitis 10.5 NCAM1 CD2
9 gastric small cell carcinoma 10.5 NCAM1 B3GAT1
10 polyclonal hypergammaglobulinemia 10.4 CD8A CD2
11 specific bursitis often of occupational origin 10.4 CD8A CD2
12 inflammatory bowel disease 16 10.4 CD7 CD2
13 olecranon bursitis 10.3 CD8A CD2
14 b-cell expansion with nfkb and t-cell anergy 10.3 FCGR3B FASLG CCL5
15 respiratory syncytial virus infectious disease 10.2 CCL5 CCL3
16 chronic eosinophilic pneumonia 10.1 ITGAM CCL5
17 t-cell adult acute lymphocytic leukemia 10.1 CD7 CD2
18 acute cervicitis 10.1 CCL5 CCL4
19 japanese spotted fever 10.1 CCL4L1 CCL4
20 orofacial granulomatosis 10.0 CCR5 CCL5 CCL3
21 necatoriasis 10.0 CCL4 CCL3
22 omsk hemorrhagic fever 9.9 CCL5 CCL4L1 CCL4
23 thymic dysplasia 9.8 IL15 CD7 CD2
24 stachybotrys chartarum 9.8 CCL5 CCL4 CCL3
25 helsmoortel-van der aa syndrome 9.8 NCAM1 CD7
26 sezary's disease 9.8 IL15 CD7 CD2
27 exposure keratitis 9.8 CCL4L1 CCL4
28 demyelinating disease 9.7 CCL5 CCL4 CCL3
29 aleukemic leukemia cutis 9.7 NCAM1 FUT4 CD7
30 whiplash 9.6 CCR5 CCL5 CCL4 CCL3
31 systemic lupus erythematosus 9.5 ITGAM FCGR3B FCGR3A FASLG CCR5 CCL5
32 human immunodeficiency virus type 1 9.3 CXCR1 CCR5 CCL5 CCL4 CCL3
33 pulmonary fibrosis, idiopathic 9.3 FASLG CXCR1 CCL5 CCL4 CCL3
34 human immunodeficiency virus infectious disease 9.2 CCR5 CCL5 CCL4L1 CCL4 CCL3
35 leukemia, acute myeloid 9.1 NCAM1 ITGAM FUT4 CD7 CD2
36 viral infectious disease 9.0 IL15 CCR5 CCL5 CCL4 CCL3
37 malaria 8.9 IL15 FASLG CCL5 CCL4 CCL3

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

Symptoms:

12
  • fever

MGI Mouse Phenotypes related to Chronic Nk-Cell Lymphocytosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CCL5 CCR5 CD7 CD8A CXCR1 FASLG
2 immune system MP:0005387 9.32 CCL5 CCR5 CD7 CD8A CXCR1 FASLG

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Search Clinical Trials , NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

41
Nk Cells, Skin, T Cells

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

(show all 13)
# Title Authors PMID Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. 38
26234181 2015
2
Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. 38
20378561 2010
3
Clinical analysis of 52 patients with granular lymphocyte proliferative disorder (GLPD) showed frequent anemia in indolent T-cell GLPD in Japan. 38
19220421 2009
4
[Analysis of chemokine receptor expression in aggressive NK-cell leukemia and chronic NK-cell lymphocytosis]. 38
18277590 2008
5
Chronic lymphocytosis of functionally immature natural killer cells. 38
17604094 2007
6
Chemokine system and tissue infiltration in aggressive NK-cell leukemia. 38
17123604 2007
7
Significance of chemokine receptor expression in aggressive NK cell leukemia. 38
15902300 2005
8
Natural killer cells and the syndrome of chronic natural killer cell lymphocytosis. 38
11378540 2001
9
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. 38
11286541 2001
10
T-large granular lymphocyte leukemia accompanied by an increase of natural killer cells (CD3-) and associated with ulcerative colitis and autoimmune hepatitis. 38
11342376 2001
11
Chronic lymphatic leukemias of T and NK cell type. 38
9178839 1997
12
Chronic natural killer cell lymphocytosis. 38
8624463 1996
13
Demonstration of clonality, by X-linked DNA analysis, in chronic natural killer cell lymphocytosis and successful therapy with oral cyclophosphamide. 38
1350651 1992

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

Pathways related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 NCAM1 ITGAM IL15 FCGR3B FCGR3A FASLG
2
Show member pathways
13.76 ITGAM IL15 FASLG CXCR1 CD2 CCR5
3
Show member pathways
13.58 IL15 FASLG CXCR1 CD2 CCR5 CCL5
4
Show member pathways
13.31 ITGAM CXCR1 CCR5 CCL5 CCL4L1 CCL4
5
Show member pathways
13.25 NCAM1 ITGAM IL15 FASLG CCR5 CCL5
6
Show member pathways
13.21 ITGAM IL15 FASLG CXCR1 CD2 CCR5
7
Show member pathways
13.18 IL15 FASLG CXCR1 CD2 CCR5 CCL5
8
Show member pathways
12.98 FASLG CCL5 CCL4L1 CCL4 CCL3
9
Show member pathways
12.88 FASLG CCR5 CCL5 CCL4L1 CCL4 CCL3
10
Show member pathways
12.81 FASLG CXCR1 CCR5 CCL5 CCL4L1 CCL4
11 12.47 NCAM1 FASLG CD8A CD2 CCL5
12
Show member pathways
12.17 ITGAM FCGR3B FCGR3A CCR5
13
Show member pathways
12.14 ITGAM CXCR1 CCR5 CCL5 CCL4L1 CCL4
14
Show member pathways
12.14 CXCR1 CCR5 CCL5 CCL4 CCL3
15 12.03 NCAM1 ITGAM CD8A CD2
16 12.01 ITGAM FCGR3B FCGR3A
17
Show member pathways
11.99 IL15 CD2 CCL5 CCL4 CCL3
18
Show member pathways
11.92 ITGAM FCGR3B FCGR3A
19 11.9 NCAM1 ITGAM IL15 CD8A CD2
20 11.81 ITGAM CD8A CD7 CD2
21
Show member pathways
11.79 FASLG CD8A CCR5 CCL4L1 CCL4 CCL3
22 11.78 IL15 CCL5 CCL3
23 11.76 ITGAM FCGR3B FCGR3A
24 11.72 CCL4L1 CCL4 CCL3
25 11.67 NCAM1 ITGAM CD8A
26 11.59 CCL5 CCL4 CCL3
27 11.47 CCR5 CCL5 CCL4 CCL3
28 11.34 NCAM1 ITGAM IL15 CD8A CD7 CCL3
29 11.01 FUT4 B3GAT1
30 10.95 IL15 FCGR3B FCGR3A CCL5 CCL4 CCL3
31 10.93 IL15 FASLG CD2 CCL5 CCL4L1 CCL4
32 10.83 ITGAM IL15 FASLG CD2 CCL5 CCL4L1

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 ITGAM IL15 FASLG CCL5 CCL4L1 CCL4
2 extracellular region GO:0005576 9.81 NCAM1 IL15 FCGR3B FASLG CD8A CCL5
3 cell surface GO:0009986 9.5 NCAM1 ITGAM IL15 FUT4 FASLG CD2
4 plasma membrane raft GO:0044853 9.4 ITGAM CD8A
5 external side of plasma membrane GO:0009897 9.23 NCAM1 ITGAM FCGR3A FASLG CXCR1 CD8A
6 plasma membrane GO:0005886 10.06 NKD1 NCAM1 ITGAM FCGR3B FCGR3A FASLG
7 integral component of membrane GO:0016021 10.03 NCAM1 ITGAM FUT4 FCGR3B FCGR3A FASLG

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 IL15 CCR5 CCL5 CCL4L1 CCL4 CCL3
2 positive regulation of GTPase activity GO:0043547 9.96 CCL5 CCL4L1 CCL4 CCL3
3 cell surface receptor signaling pathway GO:0007166 9.93 CXCR1 CD8A CD2 CCR5
4 cytokine-mediated signaling pathway GO:0019221 9.93 ITGAM FASLG CCR5 CCL5 CCL4 CCL3
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 CCL5 CCL4L1 CCL4 CCL3
6 MAPK cascade GO:0000165 9.91 NCAM1 CCR5 CCL5 CCL3
7 cellular response to tumor necrosis factor GO:0071356 9.88 CCL5 CCL4L1 CCL4 CCL3
8 chemotaxis GO:0006935 9.88 CXCR1 CCR5 CCL5 CCL4 CCL3
9 cellular response to interferon-gamma GO:0071346 9.86 CCL5 CCL4L1 CCL4 CCL3
10 cell chemotaxis GO:0060326 9.85 CXCR1 CCR5 CCL5 CCL3
11 calcium ion transport GO:0006816 9.84 CCR5 CCL5 CCL3
12 cellular response to interleukin-1 GO:0071347 9.84 CCL5 CCL4L1 CCL4 CCL3
13 response to toxic substance GO:0009636 9.82 CCL5 CCL4 CCL3
14 calcium-mediated signaling GO:0019722 9.8 CXCR1 CCR5 CCL3
15 cell-cell signaling GO:0007267 9.8 IL15 FASLG CCR5 CCL5 CCL4 CCL3
16 T cell activation GO:0042110 9.76 CD8A CD7 CD2
17 positive regulation of calcium ion transport GO:0051928 9.74 CCL5 CCL4 CCL3
18 monocyte chemotaxis GO:0002548 9.73 CCL5 CCL4L1 CCL4 CCL3
19 dendritic cell chemotaxis GO:0002407 9.7 CXCR1 CCR5 CCL5
20 negative regulation by host of viral transcription GO:0043922 9.67 CCL5 CCL4 CCL3
21 lymphocyte chemotaxis GO:0048247 9.67 CCL5 CCL4L1 CCL4 CCL3
22 positive regulation of calcium-mediated signaling GO:0050850 9.65 CCL4 CCL3
23 regulation of T cell differentiation GO:0045580 9.65 IL15 CD2
24 neutrophil chemotaxis GO:0030593 9.65 CXCR1 CCL5 CCL4L1 CCL4 CCL3
25 macrophage chemotaxis GO:0048246 9.64 CCL5 CCL3
26 response to cholesterol GO:0070723 9.62 CCR5 CCL3
27 signaling GO:0023052 9.61 CCR5 CCL3
28 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.6 CCR5 CCL3
29 negative regulation of macrophage apoptotic process GO:2000110 9.59 CCR5 CCL5
30 positive regulation of natural killer cell chemotaxis GO:2000503 9.58 CCL5 CCL4 CCL3
31 eosinophil chemotaxis GO:0048245 9.46 CCL5 CCL4L1 CCL4 CCL3
32 chemokine-mediated signaling pathway GO:0070098 9.43 CXCR1 CCR5 CCL5 CCL4L1 CCL4 CCL3
33 immune response GO:0006955 9.36 IL15 FCGR3B FCGR3A FASLG CXCR1 CD8A
34 G protein-coupled receptor signaling pathway GO:0007186 10.14 CXCR1 CCR5 CCL5 CCL4L1 CCL4 CCL3

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.72 IL15 FASLG CCL5 CCL4 CCL3
2 chemokine activity GO:0008009 9.56 CCL5 CCL4L1 CCL4 CCL3
3 phosphatidylinositol phospholipase C activity GO:0004435 9.51 CCR5 CCL5
4 chemokine binding GO:0019956 9.49 CXCR1 CCR5
5 C-C chemokine binding GO:0019957 9.48 CXCR1 CCR5
6 C-C chemokine receptor activity GO:0016493 9.46 CXCR1 CCR5
7 chemokine receptor activity GO:0004950 9.43 CXCR1 CCR5
8 IgG binding GO:0019864 9.4 FCGR3B FCGR3A
9 phospholipase activator activity GO:0016004 9.37 CCL5 CCL3
10 CCR5 chemokine receptor binding GO:0031730 9.33 CCL5 CCL4 CCL3
11 CCR chemokine receptor binding GO:0048020 9.26 CCL5 CCL4L1 CCL4 CCL3
12 CCR1 chemokine receptor binding GO:0031726 8.8 CCL5 CCL4 CCL3

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....