MCID: CHR068
MIFTS: 34

Chronic Nk-Cell Lymphocytosis

Categories: Immune diseases

Aliases & Classifications for Chronic Nk-Cell Lymphocytosis

MalaCards integrated aliases for Chronic Nk-Cell Lymphocytosis:

Name: Chronic Nk-Cell Lymphocytosis 12 15
Chronic Lymphoproliferative Disorder of Nk-Cells 73
Nk-Cell Large Granular Lymphocyte Lymphocytosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7465
NCIt 50 C39591
UMLS 73 C1512709

Summaries for Chronic Nk-Cell Lymphocytosis

MalaCards based summary : Chronic Nk-Cell Lymphocytosis, also known as chronic lymphoproliferative disorder of nk-cells, is related to transient neonatal neutropenia and renal adenoma. An important gene associated with Chronic Nk-Cell Lymphocytosis is B3GAT1 (Beta-1,3-Glucuronyltransferase 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Methotrexate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include nk cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Chronic Nk-Cell Lymphocytosis

Diseases related to Chronic Nk-Cell Lymphocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 transient neonatal neutropenia 10.8 FCGR3A FCGR3B
2 renal adenoma 10.8 B3GAT1 NCAM1
3 epithelial predominant wilms' tumor 10.7 B3GAT1 NCAM1
4 lethal midline granuloma 10.7 CD2 NCAM1
5 lymphocytic gastritis 10.7 B3GAT1 FASLG
6 spastic paraplegia 32, autosomal recessive 10.7 B3GAT1 FCGR3A FCGR3B
7 diffuse infiltrative lymphocytosis syndrome 10.6 B3GAT1 FCGR3A FCGR3B
8 orbital plasma cell granuloma 10.6 FCGR3A FCGR3B NCAM1
9 chronic orbital inflammation 10.6 FCGR3A FCGR3B NCAM1
10 pericoronitis 10.6 CD2 NCAM1
11 rheumatic myocarditis 10.6 CD2 FCGR3A FCGR3B
12 gastric small cell carcinoma 10.5 B3GAT1 NCAM1
13 adult lymphoma 10.5 CD2 FCGR3A
14 pediatric lymphoma 10.4 B3GAT1 FCGR3A FCGR3B NCAM1
15 t-cell large granular lymphocyte leukemia 10.4 FASLG NCAM1
16 b-cell expansion with nfkb and t-cell anergy 10.4 CCL5 FASLG FCGR3B
17 inflammatory bowel disease 16 10.3 CD2 CD7
18 acute cervicitis 10.3 CCL4 CCL5
19 neutropenia 10.3 FASLG FCGR3A FCGR3B
20 folliculitis 10.3 CCL5 FCGR3A
21 respiratory syncytial virus infectious disease 10.3 CCL3 CCL5
22 japanese spotted fever 10.2 CCL4 CCL4L1
23 acquired immunodeficiency syndrome 10.1 CCL3 CCR5 FCGR3A
24 exanthema subitum 10.1 CD7 FCGR3A FCGR3B
25 necatoriasis 10.1 CCL3 CCL4
26 orofacial granulomatosis 10.1 CCL3 CCL5 CCR5
27 poliomyelitis 10.0 FCGR3A FCGR3B
28 omsk hemorrhagic fever 10.0 CCL4 CCL4L1 CCL5
29 stachybotrys chartarum 9.9 CCL3 CCL4 CCL5
30 exposure keratitis 9.8 CCL4 CCL4L1
31 demyelinating disease 9.8 CCL3 CCL4 CCL5
32 thymic dysplasia 9.7 CD2 CD7 IL15
33 sezary's disease 9.7 CD2 CD7 IL15
34 systemic lupus erythematosus 9.6 CCL5 FASLG FCGR3A FCGR3B ITGAM
35 whiplash 9.6 CCL3 CCL4 CCL5 CCR5
36 viral infectious disease 9.5 CCL3 CCL4 CCL5 CCR5
37 aleukemic leukemia cutis 9.4 CD7 FUT4 NCAM1
38 multiple sclerosis 9.3 CCL3 CCL4 CCL5 CCR5
39 pulmonary fibrosis, idiopathic 9.2 CCL3 CCL4 CCL5 CXCR1 FASLG
40 human immunodeficiency virus infectious disease 9.1 CCL3 CCL4 CCL4L1 CCL5 CCR5
41 human immunodeficiency virus type 1 9.0 CCL3 CCL4 CCL5 CCR5 CXCR1 FCGR3B
42 malaria 8.8 CCL3 CCL4 CCL5 FASLG IL15
43 leukemia, acute myeloid 8.7 CD2 CD7 FUT4 ITGAM NCAM1

Graphical network of the top 20 diseases related to Chronic Nk-Cell Lymphocytosis:



Diseases related to Chronic Nk-Cell Lymphocytosis

Symptoms & Phenotypes for Chronic Nk-Cell Lymphocytosis

MGI Mouse Phenotypes related to Chronic Nk-Cell Lymphocytosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCL5 CCR5 CD7 CXCR1 FASLG FCGR3B
2 immune system MP:0005387 9.28 CCR5 CD7 CXCR1 FASLG FCGR3B FUT4

Drugs & Therapeutics for Chronic Nk-Cell Lymphocytosis

Drugs for Chronic Nk-Cell Lymphocytosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
4
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
5 Alkylating Agents Phase 2
6 Folic Acid Antagonists Phase 2
7 Cyclosporins Phase 2
8 Dermatologic Agents Phase 2
9 Nucleic Acid Synthesis Inhibitors Phase 2
10 Vitamin B Complex Phase 2
11 Immunosuppressive Agents Phase 2
12 Antirheumatic Agents Phase 2
13 Antimetabolites Phase 2
14 Antimetabolites, Antineoplastic Phase 2
15 Antineoplastic Agents, Alkylating Phase 2
16 Folate Nutraceutical Phase 2
17 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia Unknown status NCT01976182 Phase 2 Methotrexate;Cyclophosphamide
2 Registry of the German CLL Study Group Recruiting NCT02863692

Search NIH Clinical Center for Chronic Nk-Cell Lymphocytosis

Genetic Tests for Chronic Nk-Cell Lymphocytosis

Anatomical Context for Chronic Nk-Cell Lymphocytosis

MalaCards organs/tissues related to Chronic Nk-Cell Lymphocytosis:

41
Nk Cells

Publications for Chronic Nk-Cell Lymphocytosis

Articles related to Chronic Nk-Cell Lymphocytosis:

# Title Authors Year
1
Clinicopathological and phenotypic features of chronic NK cell lymphocytosis identified among patients with asymptomatic lymphocytosis. ( 26234181 )
2015
2
Decreased natural killer (NK) cell function in chronic NK cell lymphocytosis associated with decreased surface expression of CD11b. ( 11286541 )
2001

Variations for Chronic Nk-Cell Lymphocytosis

Expression for Chronic Nk-Cell Lymphocytosis

Search GEO for disease gene expression data for Chronic Nk-Cell Lymphocytosis.

Pathways for Chronic Nk-Cell Lymphocytosis

Pathways related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 CCL3 CCL4 CCL5 CCR5 CXCR1 FASLG
2
Show member pathways
13.68 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
3
Show member pathways
13.47 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
4
Show member pathways
13.25 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
5
Show member pathways
13.14 CCL3 CCL4 CCL5 CCR5 FASLG IL15
6
Show member pathways
13.04 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
7
Show member pathways
12.85 CCL3 CCL4 CCL4L1 CCL5 FASLG
8
Show member pathways
12.8 CCL3 CCL4 CCL4L1 CCL5 CCR5 CD2
9
Show member pathways
12.7 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
10 12.41 CCL5 CD2 FASLG NCAM1
11
Show member pathways
12.1 CCR5 FCGR3A FCGR3B ITGAM
12 11.98 FCGR3A FCGR3B ITGAM
13 11.95 CD2 ITGAM NCAM1
14
Show member pathways
11.91 CCL3 CCL4 CCL5 CD2 IL15
15 11.82 CD2 IL15 ITGAM NCAM1
16 11.75 CD2 CD7 ITGAM
17
Show member pathways
11.72 CCL3 CCL4 CCL5 CCR5 CXCR1
18 11.71 CCL3 CCL5 IL15
19 11.69 CCL3 CCL4 CCL4L1
20
Show member pathways
11.61 CCL3 CCL4 CCL4L1 CCR5 FASLG
21 11.53 CCL3 CCL4 CCL5
22 11.47 FCGR3A FCGR3B ITGAM
23 11.36 CCL3 CCL4 CCL5 CCR5
24 10.97 B3GAT1 FUT4
25 10.92 CCL3 CD7 IL15 ITGAM NCAM1

GO Terms for Chronic Nk-Cell Lymphocytosis

Cellular components related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 B3GAT1 CCL3 CCL4 CCL5 CD2 FASLG
2 extracellular space GO:0005615 9.8 CCL3 CCL4 CCL4L1 CCL5 FASLG IL15
3 cell surface GO:0009986 9.5 CCR5 CD2 FASLG FUT4 IL15 ITGAM
4 external side of plasma membrane GO:0009897 9.1 CCR5 CD2 FASLG FCGR3A ITGAM NCAM1

Biological processes related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CCL3 CCL4 CCL4L1 CCL5 CCR5 IL15
2 positive regulation of GTPase activity GO:0043547 9.94 CCL3 CCL4 CCL4L1 CCL5
3 MAPK cascade GO:0000165 9.92 CCL3 CCL5 CCR5 NCAM1
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 CCL3 CCL4 CCL4L1 CCL5
5 cell-cell signaling GO:0007267 9.91 CCL3 CCL4 CCL5 CCR5 FASLG IL15
6 cellular response to tumor necrosis factor GO:0071356 9.88 CCL3 CCL4 CCL4L1 CCL5
7 cytokine-mediated signaling pathway GO:0019221 9.88 CCL3 CCL4 CCL5 CCR5 FASLG ITGAM
8 cellular response to interferon-gamma GO:0071346 9.87 CCL3 CCL4 CCL4L1 CCL5
9 cellular response to interleukin-1 GO:0071347 9.85 CCL3 CCL4 CCL4L1 CCL5
10 chemotaxis GO:0006935 9.85 CCL3 CCL4 CCL5 CCR5 CXCR1
11 positive regulation of inflammatory response GO:0050729 9.84 CCL3 CCL4 CCL4L1 IL15
12 calcium ion transport GO:0006816 9.83 CCL3 CCL5 CCR5
13 response to toxic substance GO:0009636 9.81 CCL3 CCL4 CCL5
14 neutrophil chemotaxis GO:0030593 9.8 CCL3 CCL4 CCL4L1 CCL5
15 positive regulation of calcium ion transport GO:0051928 9.75 CCL3 CCL4 CCL5
16 dendritic cell chemotaxis GO:0002407 9.7 CCL5 CCR5 CXCR1
17 monocyte chemotaxis GO:0002548 9.67 CCL3 CCL4 CCL4L1 CCL5
18 negative regulation by host of viral transcription GO:0043922 9.65 CCL3 CCL4 CCL5
19 positive regulation of calcium-mediated signaling GO:0050850 9.64 CCL3 CCL4
20 regulation of T cell differentiation GO:0045580 9.63 CD2 IL15
21 macrophage chemotaxis GO:0048246 9.62 CCL3 CCL5
22 response to cholesterol GO:0070723 9.61 CCL3 CCR5
23 immune response GO:0006955 9.61 CCL3 CCL4 CCL5 CCR5 CD7 FASLG
24 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.6 CCL3 CCR5
25 negative regulation of macrophage apoptotic process GO:2000110 9.59 CCL5 CCR5
26 lymphocyte chemotaxis GO:0048247 9.56 CCL3 CCL4 CCL4L1 CCL5
27 positive regulation of natural killer cell chemotaxis GO:2000503 9.5 CCL3 CCL4 CCL5
28 eosinophil chemotaxis GO:0048245 9.46 CCL3 CCL4 CCL4L1 CCL5
29 chemokine-mediated signaling pathway GO:0070098 9.1 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
30 G-protein coupled receptor signaling pathway GO:0007186 10.12 CCL3 CCL4 CCL4L1 CCL5 CCR5 CXCR1
31 regulation of signaling receptor activity GO:0010469 10.03 CCL3 CCL4 CCL4L1 CCL5 FASLG IL15

Molecular functions related to Chronic Nk-Cell Lymphocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.72 CCL3 CCL4 CCL5 FASLG IL15
2 chemokine activity GO:0008009 9.56 CCL3 CCL4 CCL4L1 CCL5
3 phosphatidylinositol phospholipase C activity GO:0004435 9.46 CCL5 CCR5
4 chemokine receptor activity GO:0004950 9.43 CCR5 CXCR1
5 IgG binding GO:0019864 9.4 FCGR3A FCGR3B
6 phospholipase activator activity GO:0016004 9.37 CCL3 CCL5
7 CCR5 chemokine receptor binding GO:0031730 9.33 CCL3 CCL4 CCL5
8 CCR chemokine receptor binding GO:0048020 9.26 CCL3 CCL4 CCL4L1 CCL5
9 CCR1 chemokine receptor binding GO:0031726 8.8 CCL3 CCL4 CCL5

Sources for Chronic Nk-Cell Lymphocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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