Chronic Orbital Inflammation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation ¹² ¹⁵

Chronic Inflammation of Orbit ¹² ⁷¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the eye and adnexa

Disorders of eyelid, lacrimal system and orbit

Disorders of orbit

Chronic inflammatory disorders of orbit

External Ids:

Disease Ontology ¹² DOID:1397

ICD9CM ³⁴ 376.1

SNOMED-CT ⁶⁷ 44729001

ICD10 ³² H05.1

UMLS ⁷¹ C0155261

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Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to anca-associated vasculitis and purulent acute otitis media. An important gene associated with Chronic Orbital Inflammation is PRTN3 (Proteinase 3). Affiliated tissues include eye and thyroid, and related phenotype is immune system.

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Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)

#	Related Disease	Score	Top Affiliating Genes
1	anca-associated vasculitis	10.3	PRTN3 CTLA4
2	purulent acute otitis media	10.3	PRTN3 CRP
3	frontal sinusitis	10.3	PRTN3 CRP
4	bicipital tenosynovitis	10.3	PRTN3 CRP
5	tenosynovitis	10.3	PRTN3 CRP
6	ethmoid sinusitis	10.3	PRTN3 CRP
7	splenic tuberculosis	10.3	PRTN3 CRP
8	subacute bacterial endocarditis	10.3	PRTN3 CRP
9	maxillary sinusitis	10.2	PRTN3 CRP
10	branch retinal artery occlusion	10.2	PRTN3 CRP
11	mastoiditis	10.2	PRTN3 CRP
12	cogan syndrome	10.2	PRTN3 CRP
13	aortitis	10.2	PRTN3 CRP
14	chondromalacia	10.2	PRTN3 CRP
15	lung abscess	10.2	PRTN3 CRP
16	splenic infarction	10.2	PRTN3 CRP
17	pyuria	10.2	PRTN3 CRP
18	central retinal artery occlusion	10.2	PRTN3 CRP
19	cryptogenic organizing pneumonia	10.2	PRTN3 CRP
20	tracheal disease	10.2	PRTN3 CRP
21	autoimmune vasculitis	10.2	PRTN3 CRP
22	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.2	TSHR CTLA4
23	mononeuropathy	10.2	PRTN3 CRP
24	tendinitis	10.2	PRTN3 CRP
25	acute proliferative glomerulonephritis	10.2	PRTN3 CRP
26	nonbacterial thrombotic endocarditis	10.2	PRTN3 CRP
27	suppurative thyroiditis	10.2	TSHR CRP
28	acute frontal sinusitis	10.2	PRTN3 LTA
29	pleural lipoma	10.2	PRTN3 PIK3C2A
30	rapidly progressive glomerulonephritis	10.2	PRTN3 CRP
31	ecthyma	10.2	MORC3 CRP
32	exophthalmos	10.2	TSHR PRTN3
33	subacute thyroiditis	10.2	TSHR CRP
34	intestinal perforation	10.2	CTLA4 CRP
35	pyomyositis	10.1	PIK3C2A CRP
36	plasma protein metabolism disease	10.1	PRTN3 CRP
37	ornithosis	10.1	PIK3C2A CRP
38	basidiobolomycosis	10.1	PIK3C2A CRP
39	acute maxillary sinusitis	10.1	LTA CRP
40	skin sarcoidosis	10.1	CTLA4 ACE
41	chickenpox	10.1	CTLA4 CRP
42	spondylolisthesis	10.1	PIK3C2A CRP
43	acute dacryocystitis	10.1	PRTN3 ACE
44	erysipelas	10.1	PIK3C2A CRP
45	sympathetic ophthalmia	10.1	LTA CTLA4
46	acute dacryoadenitis	10.1	CRP ACE
47	compartment syndrome	10.1	PIK3C2A CRP
48	mediastinum teratoma	10.1	CRP ACE
49	cardiac tuberculosis	10.1	CRP ACE
50	middle ear disease	10.1	PRTN3 CRP

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:

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Symptoms & Phenotypes for Chronic Orbital Inflammation

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.23	ACE CRP CTLA4 LTA PIK3C2A PRTN3

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Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

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Genetic Tests for Chronic Orbital Inflammation

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Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

⁴⁰

Eye, Thyroid

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Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

#	Title	Authors	PMID	Year
1	Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ⁶¹	Galindo-Ferreiro A...Schellini SA	29515429	2017
2	Enlargement of the infraorbital nerve: an important sign associated with orbital reactive lymphoid hyperplasia or immunoglobulin g4-related disease. ⁶¹	Hardy TG...Rose GE	24613826	2014
3	Selenium supplementation in thyroid associated ophthalmopathy: an update. ⁶¹	Dharmasena A	24790886	2014
4	Orbital inflammation in IgG4-related sclerosing disease. ⁶¹	Pasquali T...Singh AD	21957960	2011
5	[Chronic or subacute orbital inflammation (inflammatory pseudotumors)]. ⁶¹	Civit T...Joud A	20334884	2010
6	Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ⁶¹	Cotliar JM...Meyer DR	18806668	2008
7	Treatment of intraorbital lesions using the Accuray CyberKnife system. ⁶¹	Hirschbein MJ...Adler JR	18415869	2008
8	Magnetic resonance imaging features of orbital inflammation with intracranial extension in four dogs. ⁶¹	Kneissl S...Nell B	17899971	2007
9	Sinuorbital complications after intranasal cocaine abuse. ⁶¹	Neugebauer P...Russmann W	15545138	2004
10	Mouse exophthalmic chronic orbital inflammatory disease. Induction by human leucocyte intracellular Mollicutes. ⁶¹	Wirostko E...Wirostko W	3140479	1988

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Genes for Chronic Orbital Inflammation

Genes related to Chronic Orbital Inflammation (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PRTN3	Proteinase 3	Protein Coding	5.84	DISEASES inferred ¹⁵
2	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	5.36	DISEASES inferred ¹⁵
3	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	5.22	DISEASES inferred ¹⁵
4	CRP	C-Reactive Protein	Protein Coding	5.1	DISEASES inferred ¹⁵
5	MORC3	MORC Family CW-Type Zinc Finger 3	Protein Coding	4.84	DISEASES inferred ¹⁵
6	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	4.68	DISEASES inferred ¹⁵
7	ACE	Angiotensin I Converting Enzyme	Protein Coding	4.65	DISEASES inferred ¹⁵
8	TRIM33	Tripartite Motif Containing 33	Protein Coding	4.43	DISEASES inferred ¹⁵
9	LTA	Lymphotoxin Alpha	Protein Coding	4.41	DISEASES inferred ¹⁵

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Variations for Chronic Orbital Inflammation

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Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

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Pathways for Chronic Orbital Inflammation

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GO Terms for Chronic Orbital Inflammation

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of fibroblast proliferation	GO:0048147	8.62	MORC3 LTA

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Sources for Chronic Orbital Inflammation

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⁷⁴ Wikipedia