Chronic Orbital Inflammation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation ¹² ¹⁵

Chronic Inflammation of Orbit ¹² ⁷³

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of eyelid, lacrimal system and orbit

Disorders of orbit

Chronic inflammatory disorders of orbit

External Ids:

Disease Ontology ¹² DOID:1397

ICD10 ³³ H05.1

ICD9CM ³⁵ 376.1 376.10

SNOMED-CT ⁶⁸ 194007005 194011004 44729001

UMLS ⁷³ C0155261

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Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to scleral disease and iritis. An important gene associated with Chronic Orbital Inflammation is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include eye, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)

#	Related Disease	Score	Top Affiliating Genes
1	scleral disease	10.8	MRAP TNFRSF1B
2	iritis	10.8	MRAP TNFRSF1B
3	pustulosis of palm and sole	10.8	MRAP TNFRSF1B
4	trichostrongylosis	10.8	CD79A PIK3C2A
5	tenosynovitis	10.7	MRAP TNFRSF1B
6	spastic paraplegia 32, autosomal recessive	10.7	FCGR3A FCGR3B
7	trichostrongyloidiasis	10.7	CD79A PIK3C2A
8	spinocerebellar ataxia, autosomal recessive 10	10.7	CD79A IFNA2
9	rheumatic myocarditis	10.7	FCGR3A FCGR3B
10	myxedema	10.7	CTLA4 TSHR
11	penile disease	10.7	IFNA2 MRAP
12	rheumatoid lung disease	10.6	MUC1 TNFRSF1B
13	sarcomatoid renal cell carcinoma	10.6	IFNA2 MUC1
14	phlebotomus fever	10.6	CD79A IFNA2
15	chorioretinitis	10.5	CD79A MRAP
16	cryptogenic organizing pneumonia	10.5	MUC1 PIK3C2A
17	ovarian cystic teratoma	10.5	FCGR3A FCGR3B IFNA2
18	urethritis	10.5	CD79A MRAP
19	mycosis fungoides	10.5	CTLA4 IFNA2 TNFRSF1B
20	pericoronitis	10.5	NCAM1 TNFRSF1B
21	granulomatous hepatitis	10.5	CD79A IFNA2 TNFRSF1B
22	poliomyelitis	10.5	FCGR3A FCGR3B
23	cervicitis	10.5	CD79A MRAP
24	posterior scleritis	10.4	MRAP PRTN3
25	hypopyon	10.4	MRAP NCAM1
26	diffuse infiltrative lymphocytosis syndrome	10.4	FCGR3A FCGR3B MRAP
27	anca-associated vasculitis	10.4	CTLA4 PRTN3
28	cervix disease	10.4	CD79A MRAP
29	sclerosing keratitis	10.4	CD79A PRTN3
30	peroneal neuropathy	10.4	MME TNFRSF1B
31	transient neonatal neutropenia	10.4	CD79A FCGR3A FCGR3B
32	acute salpingitis	10.4	CD79A MRAP TNFRSF1B
33	pleuropneumonia	10.4	CD79A FCGR3A FCGR3B
34	monoclonal paraproteinemia	10.4	CD79A PRTN3
35	hypersensitivity reaction type iv disease	10.4	CD79A MRAP TNFRSF1B
36	spondyloarthropathy 1	10.4	CD79A MRAP TNFRSF1B
37	intestinal disease	10.4	CD79A MRAP TNFRSF1B
38	parasitic ichthyosporea infectious disease	10.4	CD79A NCAM1
39	vulvitis	10.3	CD79A MRAP
40	rhinosporidiosis	10.3	CD79A NCAM1
41	ovarian serous cystadenofibroma	10.3	MUC1 NCAM1
42	precursor t-lymphoblastic lymphoma/leukemia	10.3	CD79A MME
43	encapsulated thymoma	10.3	CD79A MME
44	transitional meningioma	10.3	MUC1 NCAM1
45	precursor lymphoblastic lymphoma/leukemia	10.3	CD79A MME
46	myxopapillary ependymoma	10.3	MUC1 NCAM1
47	rapidly progressive glomerulonephritis	10.3	CD79A PRTN3
48	hypothyroidism	10.2	CTLA4 IFNA2 PIK3C2A TSHR
49	malignant skin fibrous histiocytoma	10.2	CTLA4 IFNA2 NCAM1
50	chronic nk-cell lymphocytosis	10.2	FCGR3A FCGR3B NCAM1

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:

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Symptoms & Phenotypes for Chronic Orbital Inflammation

GenomeRNAi Phenotypes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.77	MUC1 NCAM1 PIK3C2A
2	Decreased viability	GR00221-A-1	9.77	PIK3C2A
3	Decreased viability	GR00221-A-2	9.77	PIK3C2A
4	Decreased viability	GR00221-A-4	9.77	PIK3C2A
5	Decreased viability	GR00240-S-1	9.77	PIK3C2A
6	Decreased viability	GR00342-S-1	9.77	PIK3C2A
7	Decreased viability	GR00342-S-2	9.77	PIK3C2A
8	Decreased viability	GR00342-S-3	9.77	PIK3C2A
9	Decreased viability	GR00402-S-2	9.77	PIK3C2A MUC1 NCAM1
10	Synthetic lethal with vaccinia virus (VACV) infection	GR00362-A	9.02	CD79A FCGR3A MME NCAM1 PIK3C2A

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.28	CD79A CTLA4 CYCS FCGR3B MME PIK3C2A

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Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

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Genetic Tests for Chronic Orbital Inflammation

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Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

⁴¹

Eye

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Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

#	Title	Authors	Year
1	Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ( 29515429 )	Galindo-Ferreiro A....Schellini S.A.	2017
2	Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ( 18806668 )	Cotliar J.M....Meyer D.R.	2008

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Genes for Chronic Orbital Inflammation

Genes related to Chronic Orbital Inflammation (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	15.13	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	14.7	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	IFNA2	Interferon Alpha 2	Protein Coding	13.8	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	13.78	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	FCGR3B	Fc Fragment Of IgG Receptor IIIb	Protein Coding	13.65	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	FCGR3A	Fc Fragment Of IgG Receptor IIIa	Protein Coding	13.63	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	13.39	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	13.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	CD79A	CD79a Molecule	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	CYCS	Cytochrome C, Somatic	Protein Coding	13.3	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	13.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.27	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	MME	Membrane Metalloendopeptidase	Protein Coding	13.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	KNTC1	Kinetochore Associated 1	Protein Coding	5.89	DISEASES inferred ¹⁵
15	PRTN3	Proteinase 3	Protein Coding	3.62	DISEASES inferred ¹⁵

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Variations for Chronic Orbital Inflammation

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Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

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Pathways for Chronic Orbital Inflammation

Pathways related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.55	CD79A CTLA4 FCGR3A FCGR3B IFNA2 MME
2	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.46	CTLA4 CYCS IFNA2 TNFRSF1B TSHR
3	NF-kappaB Signaling ⁴	12.18	CD79A CTLA4 NCAM1 TNFRSF1B
4	Tuberculosis ³⁷	11.51	CYCS FCGR3A FCGR3B IFNA2
5	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.2	IFNA2 MME NCAM1
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.99	CD79A IFNA2 MME NCAM1

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GO Terms for Chronic Orbital Inflammation

Cellular components related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.63	CD79A CTLA4 MME MUC1 TNFRSF1B TSHR
2	plasma membrane	GO:0005886	9.44	CD79A CTLA4 FCGR3A FCGR3B KNTC1 MME
3	external side of plasma membrane	GO:0009897	9.26	CD79A CTLA4 FCGR3A NCAM1

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neutrophil degranulation	GO:0043312	9.56	FCGR3B MME PRTN3 TNFRSF1B
2	cytokine-mediated signaling pathway	GO:0019221	9.46	IFNA2 MUC1 PRTN3 TNFRSF1B
3	cell surface receptor signaling pathway	GO:0007166	9.26	CD79A IFNA2 TNFRSF1B TSHR
4	B cell differentiation	GO:0030183	8.8	CD79A IFNA2 TSHR

Molecular functions related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	IgG binding	GO:0019864	8.62	FCGR3A FCGR3B

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Sources for Chronic Orbital Inflammation

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