Chronic Orbital Inflammation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation ¹² ¹⁵

Chronic Inflammation of Orbit ¹² ⁷³

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of eyelid, lacrimal system and orbit

Disorders of orbit

Chronic inflammatory disorders of orbit

External Ids:

Disease Ontology ¹² DOID:1397

ICD10 ³³ H05.1

ICD9CM ³⁵ 376.1 376.10

SNOMED-CT ⁶⁸ 44729001

UMLS ⁷³ C0155261

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Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to juvenile ankylosing spondylitis and scleral disease. An important gene associated with Chronic Orbital Inflammation is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include eye, lung and skin, and related phenotypes are Decreased IL-8 secretion and Decreased viability

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Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)

#	Related Disease	Score	Top Affiliating Genes
1	juvenile ankylosing spondylitis	10.2	MRAP TNFRSF1B
2	scleral disease	10.2	MRAP TNFRSF1B
3	pustulosis of palm and sole	10.2	MRAP TNFRSF1B
4	iritis	10.2	MRAP TNFRSF1B
5	tenosynovitis	10.2	MRAP TNFRSF1B
6	myxedema	10.2	CTLA4 TSHR
7	pericoronitis	10.2	NCAM1 TNFRSF1B
8	rhinoscleroma	10.2	NCAM1 TNFRSF1B
9	penile disease	10.2	IFNA2 MRAP
10	rheumatoid lung disease	10.2	MUC1 TNFRSF1B
11	conjunctival disease	10.2	IFNA2 MRAP
12	cryptogenic organizing pneumonia	10.2	MUC1 PIK3C2A
13	panuveitis	10.2	MRAP TNFRSF1B
14	sarcomatoid renal cell carcinoma	10.2	IFNA2 MUC1
15	peroneal neuropathy	10.2	MME TNFRSF1B
16	postsurgical hypothyroidism	10.2	CSF3 TSHR
17	chickenpox	10.1	MUC1 TNFRSF1B
18	ovarian serous cystadenofibroma	10.1	MUC1 NCAM1
19	transitional meningioma	10.1	MUC1 NCAM1
20	myxopapillary ependymoma	10.1	MUC1 NCAM1
21	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.1	CTLA4 TSHR
22	mycosis fungoides	10.1	CTLA4 IFNA2 TNFRSF1B
23	lung combined type small cell carcinoma	10.1	MME NCAM1
24	extrahepatic bile duct adenocarcinoma	10.1	MME NCAM1
25	autoimmune disease of endocrine system	10.1	CTLA4 TSHR
26	adenofibroma	10.1	MME MUC1
27	perineurioma	10.1	MUC1 NCAM1
28	mammary paget's disease	10.1	CTLA4 MUC1
29	hypersensitivity reaction type iv disease	10.1	MRAP TNFRSF1B
30	spermatocele	10.1	MME NCAM1
31	rete testis neoplasm	10.1	MME NCAM1
32	adenomyoma	10.1	MME MUC1
33	malignant skin fibrous histiocytoma	10.1	CTLA4 IFNA2 NCAM1
34	malignant dermis tumor	10.1	CTLA4 IFNA2 NCAM1
35	perivascular epithelioid cell tumor	10.1	MME MUC1
36	mixed ductal-endocrine carcinoma	10.1	MUC1 NCAM1
37	mucinous tubular and spindle renal cell carcinoma	10.1	MME MUC1
38	meningeal melanocytoma	10.1	MME MUC1
39	pancreatic mucinous cystadenoma	10.1	MME MUC1
40	acute salpingitis	10.1	MME MRAP TNFRSF1B
41	cystadenoma	10.1	MME MUC1
42	pediatric lymphoma	10.1	MME NCAM1
43	histrionic personality disorder	10.0	KNTC1 MME
44	posterior scleritis	10.0	MRAP PRTN3
45	nephrogenic adenofibroma	10.0	MME NCAM1
46	hypothyroidism	10.0	CTLA4 IFNA2 PIK3C2A TSHR
47	lymphatic system cancer	10.0	MME NCAM1
48	exanthem	10.0	CTLA4 TNFRSF1B
49	ileum cancer	10.0	MME NCAM1
50	dependent personality disorder	10.0	KNTC1 MME

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:

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Symptoms & Phenotypes for Chronic Orbital Inflammation

GenomeRNAi Phenotypes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased IL-8 secretion	GR00386-A-2	9.5	CSF3 CTLA4 CYCS MME MUC1 NCAM1
2	Decreased viability	GR00055-A-2	9.44	MUC1 NCAM1 PIK3C2A
3	Decreased viability	GR00221-A-1	9.44	PIK3C2A
4	Decreased viability	GR00221-A-2	9.44	PIK3C2A
5	Decreased viability	GR00221-A-4	9.44	PIK3C2A
6	Decreased viability	GR00240-S-1	9.44	PIK3C2A
7	Decreased viability	GR00342-S-1	9.44	PIK3C2A
8	Decreased viability	GR00342-S-2	9.44	PIK3C2A
9	Decreased viability	GR00342-S-3	9.44	PIK3C2A
10	Decreased viability	GR00402-S-2	9.44	MUC1 NCAM1 PIK3C2A

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.23	CSF3 CTLA4 CYCS MME PIK3C2A PRTN3

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Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

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Genetic Tests for Chronic Orbital Inflammation

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Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

⁴¹

Eye, Lung, Skin, Bone, Testis, T Cells, Myeloid

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Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

#	Title	Authors	Year
1	Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ( 29515429 )	Galindo-Ferreiro A....Schellini S.A.	2017
2	Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ( 18806668 )		2008

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Genes for Chronic Orbital Inflammation

Genes related to Chronic Orbital Inflammation (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	15.21	DISEASES inferred ¹⁵
2	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	14.81	DISEASES inferred ¹⁵
3	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	13.87	DISEASES inferred ¹⁵
4	IFNA2	Interferon Alpha 2	Protein Coding	13.83	DISEASES inferred ¹⁵
5	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	13.48	DISEASES inferred ¹⁵
6	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	13.4	DISEASES inferred ¹⁵
7	CYCS	Cytochrome C, Somatic	Protein Coding	13.3	DISEASES inferred ¹⁵
8	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.3	DISEASES inferred ¹⁵
9	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	13.28	DISEASES inferred ¹⁵
10	MME	Membrane Metalloendopeptidase	Protein Coding	13.23	DISEASES inferred ¹⁵
11	KNTC1	Kinetochore Associated 1	Protein Coding	5.98	DISEASES inferred ¹⁵
12	PRTN3	Proteinase 3	Protein Coding	3.69	DISEASES inferred ¹⁵
13	CSF3	Colony Stimulating Factor 3	Protein Coding	2.99	DISEASES inferred ¹⁵

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Variations for Chronic Orbital Inflammation

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Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

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Pathways for Chronic Orbital Inflammation

Pathways related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.52	CSF3 CTLA4 IFNA2 MME MUC1 NCAM1
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	12.84	CSF3 IFNA2 MUC1 NCAM1 PRTN3 TNFRSF1B
3	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.29	CTLA4 CYCS IFNA2 TNFRSF1B TSHR
4	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11	IFNA2 MME NCAM1
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	10.99	CSF3 IFNA2 MME NCAM1
6	Cell adhesion_Cell-matrix glycoconjugates ²²	10.96	MUC1 NCAM1

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GO Terms for Chronic Orbital Inflammation

Cellular components related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.32	CTLA4 KNTC1 MME MRAP MUC1 NCAM1

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.02	CSF3 IFNA2 MUC1 PRTN3 TNFRSF1B

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Sources for Chronic Orbital Inflammation

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