MCID: CHR093
MIFTS: 21

Chronic Orbital Inflammation

Categories: Bone diseases, Eye diseases

Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation 12 15
Chronic Inflammation of Orbit 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1397
ICD9CM 34 376.1
SNOMED-CT 67 44729001
ICD10 32 H05.1
UMLS 71 C0155261

Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to anca-associated vasculitis and purulent acute otitis media. An important gene associated with Chronic Orbital Inflammation is PRTN3 (Proteinase 3). Affiliated tissues include eye and thyroid, and related phenotype is immune system.

Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 204)
# Related Disease Score Top Affiliating Genes
1 anca-associated vasculitis 10.3 PRTN3 CTLA4
2 purulent acute otitis media 10.3 PRTN3 CRP
3 frontal sinusitis 10.3 PRTN3 CRP
4 bicipital tenosynovitis 10.3 PRTN3 CRP
5 tenosynovitis 10.3 PRTN3 CRP
6 ethmoid sinusitis 10.3 PRTN3 CRP
7 splenic tuberculosis 10.3 PRTN3 CRP
8 subacute bacterial endocarditis 10.3 PRTN3 CRP
9 maxillary sinusitis 10.2 PRTN3 CRP
10 branch retinal artery occlusion 10.2 PRTN3 CRP
11 mastoiditis 10.2 PRTN3 CRP
12 cogan syndrome 10.2 PRTN3 CRP
13 aortitis 10.2 PRTN3 CRP
14 chondromalacia 10.2 PRTN3 CRP
15 lung abscess 10.2 PRTN3 CRP
16 splenic infarction 10.2 PRTN3 CRP
17 pyuria 10.2 PRTN3 CRP
18 central retinal artery occlusion 10.2 PRTN3 CRP
19 cryptogenic organizing pneumonia 10.2 PRTN3 CRP
20 tracheal disease 10.2 PRTN3 CRP
21 autoimmune vasculitis 10.2 PRTN3 CRP
22 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 TSHR CTLA4
23 mononeuropathy 10.2 PRTN3 CRP
24 tendinitis 10.2 PRTN3 CRP
25 acute proliferative glomerulonephritis 10.2 PRTN3 CRP
26 nonbacterial thrombotic endocarditis 10.2 PRTN3 CRP
27 suppurative thyroiditis 10.2 TSHR CRP
28 acute frontal sinusitis 10.2 PRTN3 LTA
29 pleural lipoma 10.2 PRTN3 PIK3C2A
30 rapidly progressive glomerulonephritis 10.2 PRTN3 CRP
31 ecthyma 10.2 MORC3 CRP
32 exophthalmos 10.2 TSHR PRTN3
33 subacute thyroiditis 10.2 TSHR CRP
34 intestinal perforation 10.2 CTLA4 CRP
35 pyomyositis 10.1 PIK3C2A CRP
36 plasma protein metabolism disease 10.1 PRTN3 CRP
37 ornithosis 10.1 PIK3C2A CRP
38 basidiobolomycosis 10.1 PIK3C2A CRP
39 acute maxillary sinusitis 10.1 LTA CRP
40 skin sarcoidosis 10.1 CTLA4 ACE
41 chickenpox 10.1 CTLA4 CRP
42 spondylolisthesis 10.1 PIK3C2A CRP
43 acute dacryocystitis 10.1 PRTN3 ACE
44 erysipelas 10.1 PIK3C2A CRP
45 sympathetic ophthalmia 10.1 LTA CTLA4
46 acute dacryoadenitis 10.1 CRP ACE
47 compartment syndrome 10.1 PIK3C2A CRP
48 mediastinum teratoma 10.1 CRP ACE
49 cardiac tuberculosis 10.1 CRP ACE
50 middle ear disease 10.1 PRTN3 CRP

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:



Diseases related to Chronic Orbital Inflammation

Symptoms & Phenotypes for Chronic Orbital Inflammation

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 ACE CRP CTLA4 LTA PIK3C2A PRTN3

Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

Genetic Tests for Chronic Orbital Inflammation

Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

40
Eye, Thyroid

Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

# Title Authors PMID Year
1
Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. 61
29515429 2017
2
Enlargement of the infraorbital nerve: an important sign associated with orbital reactive lymphoid hyperplasia or immunoglobulin g4-related disease. 61
24613826 2014
3
Selenium supplementation in thyroid associated ophthalmopathy: an update. 61
24790886 2014
4
Orbital inflammation in IgG4-related sclerosing disease. 61
21957960 2011
5
[Chronic or subacute orbital inflammation (inflammatory pseudotumors)]. 61
20334884 2010
6
Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. 61
18806668 2008
7
Treatment of intraorbital lesions using the Accuray CyberKnife system. 61
18415869 2008
8
Magnetic resonance imaging features of orbital inflammation with intracranial extension in four dogs. 61
17899971 2007
9
Sinuorbital complications after intranasal cocaine abuse. 61
15545138 2004
10
Mouse exophthalmic chronic orbital inflammatory disease. Induction by human leucocyte intracellular Mollicutes. 61
3140479 1988

Variations for Chronic Orbital Inflammation

Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

Pathways for Chronic Orbital Inflammation

GO Terms for Chronic Orbital Inflammation

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of fibroblast proliferation GO:0048147 8.62 MORC3 LTA

Sources for Chronic Orbital Inflammation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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