Chronic Orbital Inflammation disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation ¹² ¹⁵

Chronic Inflammation of Orbit ¹² ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of eyelid, lacrimal system and orbit

Disorders of orbit

Chronic inflammatory disorders of orbit

External Ids:

Disease Ontology ¹² DOID:1397

ICD9CM ³⁶ 376.1 376.10

SNOMED-CT ⁶⁹ 44729001

ICD10 ³⁴ H05.1

UMLS ⁷⁴ C0155261

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Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to juvenile ankylosing spondylitis and scleral disease. An important gene associated with Chronic Orbital Inflammation is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include lung, eye and pituitary, and related phenotypes are Decreased IL-8 secretion and Decreased viability

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Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)

#	Related Disease	Score	Top Affiliating Genes
1	juvenile ankylosing spondylitis	10.4	MRAP TNFRSF1B
2	scleral disease	10.4	MRAP TNFRSF1B
3	pustulosis of palm and sole	10.4	MRAP TNFRSF1B
4	iritis	10.4	MRAP TNFRSF1B
5	tenosynovitis	10.4	MRAP TNFRSF1B
6	pericoronitis	10.3	NCAM1 TNFRSF1B
7	rhinoscleroma	10.3	NCAM1 TNFRSF1B
8	cryptogenic organizing pneumonia	10.3	MUC1 PIK3C2A
9	ovarian serous cystadenofibroma	10.3	MUC1 NCAM1
10	sarcomatoid renal cell carcinoma	10.3	IFNA2 MUC1
11	transitional meningioma	10.3	MUC1 NCAM1
12	adenofibroma	10.3	MME MUC1
13	peroneal neuropathy	10.3	MME TNFRSF1B
14	myxopapillary ependymoma	10.3	MUC1 NCAM1
15	penile disease	10.3	IFNA2 MRAP
16	chickenpox	10.3	MUC1 TNFRSF1B
17	lung combined type small cell carcinoma	10.3	MME NCAM1
18	extrahepatic bile duct adenocarcinoma	10.3	MME NCAM1
19	perineurioma	10.3	MUC1 NCAM1
20	myxedema	10.3	CTLA4 TSHR
21	adenomyoma	10.3	MME MUC1
22	perivascular epithelioid cell tumor	10.2	MME MUC1
23	conjunctival disease	10.2	IFNA2 MRAP
24	postsurgical hypothyroidism	10.2	CSF3 TSHR
25	mucinous tubular and spindle renal cell carcinoma	10.2	MME MUC1
26	non-functioning pituitary adenoma	10.2	MUC1 SST
27	functioning pituitary adenoma	10.2	MUC1 SST
28	spermatocele	10.2	MME NCAM1
29	rete testis neoplasm	10.2	MME NCAM1
30	meningeal melanocytoma	10.2	MME MUC1
31	pancreatic mucinous cystadenoma	10.2	MME MUC1
32	pancreatic endocrine carcinoma	10.2	NCAM1 SST
33	pancreatoblastoma	10.2	MUC1 SST
34	encapsulated thymoma	10.2	MME SST
35	acute salpingitis	10.2	MME MRAP TNFRSF1B
36	panuveitis	10.2	MRAP TNFRSF1B
37	carcinoid syndrome	10.2	IFNA2 SST
38	villous adenoma	10.2	MUC1 SST
39	mammary paget's disease	10.1	CTLA4 MUC1
40	mycosis fungoides	10.1	CTLA4 IFNA2 TNFRSF1B
41	pediatric lymphoma	10.1	MME NCAM1
42	duodenum cancer	10.1	MUC1 SST
43	histrionic personality disorder	10.1	KNTC1 MME
44	cystadenofibroma	10.1	MME MUC1 NCAM1
45	malignant skin fibrous histiocytoma	10.1	CTLA4 IFNA2 NCAM1
46	malignant dermis tumor	10.1	CTLA4 IFNA2 NCAM1
47	dependent personality disorder	10.1	KNTC1 MME
48	posterior scleritis	10.1	MRAP PRTN3
49	mixed ductal-endocrine carcinoma	10.0	MUC1 NCAM1 SST
50	merkel cell carcinoma	10.0	MUC1 NCAM1 SST

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:

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Symptoms & Phenotypes for Chronic Orbital Inflammation

GenomeRNAi Phenotypes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased IL-8 secretion	GR00386-A-2	9.5	CSF3 CTLA4 CYCS MME MUC1 NCAM1
2	Decreased viability	GR00055-A-2	9.44	MUC1 NCAM1 PIK3C2A
3	Decreased viability	GR00221-A-1	9.44	PIK3C2A
4	Decreased viability	GR00221-A-2	9.44	PIK3C2A
5	Decreased viability	GR00221-A-4	9.44	PIK3C2A
6	Decreased viability	GR00240-S-1	9.44	PIK3C2A
7	Decreased viability	GR00342-S-1	9.44	PIK3C2A
8	Decreased viability	GR00342-S-2	9.44	PIK3C2A
9	Decreased viability	GR00342-S-3	9.44	PIK3C2A
10	Decreased viability	GR00402-S-2	9.44	MUC1 NCAM1 PIK3C2A

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.28	CSF3 CTLA4 CYCS MME PIK3C2A PRTN3

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Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

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Genetic Tests for Chronic Orbital Inflammation

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Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

⁴²

Lung, Eye, Pituitary, Skin, Bone, Testis, Myeloid

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Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

#	Title	Authors	Year
1	Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ( 29515429 )	Galindo-Ferreiro A...Schellini SA	2017
2	Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ( 18806668 )	Cotliar JM...Meyer DR	2008

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Genes for Chronic Orbital Inflammation

Genes related to Chronic Orbital Inflammation (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	15.22	DISEASES inferred ¹⁵
2	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	14.78	DISEASES inferred ¹⁵
3	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	13.9	DISEASES inferred ¹⁵
4	IFNA2	Interferon Alpha 2	Protein Coding	13.85	DISEASES inferred ¹⁵
5	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	13.48	DISEASES inferred ¹⁵
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	13.32	DISEASES inferred ¹⁵
7	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	13.31	DISEASES inferred ¹⁵
8	CYCS	Cytochrome C, Somatic	Protein Coding	13.3	DISEASES inferred ¹⁵
9	MME	Membrane Metalloendopeptidase	Protein Coding	13.24	DISEASES inferred ¹⁵
10	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	13.15	DISEASES inferred ¹⁵
11	SST	Somatostatin	Protein Coding	12.96	DISEASES inferred ¹⁵
12	KNTC1	Kinetochore Associated 1	Protein Coding	5.98	DISEASES inferred ¹⁵
13	PRTN3	Proteinase 3	Protein Coding	3.68	DISEASES inferred ¹⁵
14	CSF3	Colony Stimulating Factor 3	Protein Coding	3.02	DISEASES inferred ¹⁵

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Variations for Chronic Orbital Inflammation

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Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

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Pathways for Chronic Orbital Inflammation

Pathways related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁷ Show member pathways Signaling by Interleukins ⁶⁷	12.84	CSF3 IFNA2 MUC1 NCAM1 PRTN3 TNFRSF1B
2	Allograft rejection ³⁸ ¹ Show member pathways Antigen processing and presentation ³⁸ Asthma ³⁸ Autoimmune thyroid disease ³⁸ CTL Mediated Apoptosis ⁶⁵ Graft-versus-host disease ³⁸ Intestinal immune network for IgA production ³⁸ THC Differentiation Pathway ⁶⁵ Type I diabetes mellitus ³⁸ Viral myocarditis ³⁸	12.29	CTLA4 CYCS IFNA2 TNFRSF1B TSHR
3	Dendritic Cells Developmental Lineage Pathway ⁶⁶	11	IFNA2 MME NCAM1
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	10.99	CSF3 IFNA2 MME NCAM1

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GO Terms for Chronic Orbital Inflammation

Cellular components related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.5	CSF3 IFNA2 MUC1 NCAM1 PRTN3 SST
2	plasma membrane	GO:0005886	9.32	CTLA4 KNTC1 MME MRAP MUC1 NCAM1

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface receptor signaling pathway	GO:0007166	9.26	IFNA2 SST TNFRSF1B TSHR
2	cytokine-mediated signaling pathway	GO:0019221	9.02	CSF3 IFNA2 MUC1 PRTN3 TNFRSF1B

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Sources for Chronic Orbital Inflammation

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