MCID: CHR093
MIFTS: 28

Chronic Orbital Inflammation

Categories: Eye diseases

Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation 12 15
Chronic Inflammation of Orbit 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1397
ICD10 33 H05.1
ICD9CM 35 376.1 376.10
SNOMED-CT 68 44729001
UMLS 73 C0155261

Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to juvenile ankylosing spondylitis and scleral disease. An important gene associated with Chronic Orbital Inflammation is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include eye, lung and skin, and related phenotypes are Decreased IL-8 secretion and Decreased viability

Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 juvenile ankylosing spondylitis 10.2 MRAP TNFRSF1B
2 scleral disease 10.2 MRAP TNFRSF1B
3 pustulosis of palm and sole 10.2 MRAP TNFRSF1B
4 iritis 10.2 MRAP TNFRSF1B
5 tenosynovitis 10.2 MRAP TNFRSF1B
6 myxedema 10.2 CTLA4 TSHR
7 pericoronitis 10.2 NCAM1 TNFRSF1B
8 rhinoscleroma 10.2 NCAM1 TNFRSF1B
9 penile disease 10.2 IFNA2 MRAP
10 rheumatoid lung disease 10.2 MUC1 TNFRSF1B
11 conjunctival disease 10.2 IFNA2 MRAP
12 cryptogenic organizing pneumonia 10.2 MUC1 PIK3C2A
13 panuveitis 10.2 MRAP TNFRSF1B
14 sarcomatoid renal cell carcinoma 10.2 IFNA2 MUC1
15 peroneal neuropathy 10.2 MME TNFRSF1B
16 postsurgical hypothyroidism 10.2 CSF3 TSHR
17 chickenpox 10.1 MUC1 TNFRSF1B
18 ovarian serous cystadenofibroma 10.1 MUC1 NCAM1
19 transitional meningioma 10.1 MUC1 NCAM1
20 myxopapillary ependymoma 10.1 MUC1 NCAM1
21 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1 CTLA4 TSHR
22 mycosis fungoides 10.1 CTLA4 IFNA2 TNFRSF1B
23 lung combined type small cell carcinoma 10.1 MME NCAM1
24 extrahepatic bile duct adenocarcinoma 10.1 MME NCAM1
25 autoimmune disease of endocrine system 10.1 CTLA4 TSHR
26 adenofibroma 10.1 MME MUC1
27 perineurioma 10.1 MUC1 NCAM1
28 mammary paget's disease 10.1 CTLA4 MUC1
29 hypersensitivity reaction type iv disease 10.1 MRAP TNFRSF1B
30 spermatocele 10.1 MME NCAM1
31 rete testis neoplasm 10.1 MME NCAM1
32 adenomyoma 10.1 MME MUC1
33 malignant skin fibrous histiocytoma 10.1 CTLA4 IFNA2 NCAM1
34 malignant dermis tumor 10.1 CTLA4 IFNA2 NCAM1
35 perivascular epithelioid cell tumor 10.1 MME MUC1
36 mixed ductal-endocrine carcinoma 10.1 MUC1 NCAM1
37 mucinous tubular and spindle renal cell carcinoma 10.1 MME MUC1
38 meningeal melanocytoma 10.1 MME MUC1
39 pancreatic mucinous cystadenoma 10.1 MME MUC1
40 acute salpingitis 10.1 MME MRAP TNFRSF1B
41 cystadenoma 10.1 MME MUC1
42 pediatric lymphoma 10.1 MME NCAM1
43 histrionic personality disorder 10.0 KNTC1 MME
44 posterior scleritis 10.0 MRAP PRTN3
45 nephrogenic adenofibroma 10.0 MME NCAM1
46 hypothyroidism 10.0 CTLA4 IFNA2 PIK3C2A TSHR
47 lymphatic system cancer 10.0 MME NCAM1
48 exanthem 10.0 CTLA4 TNFRSF1B
49 ileum cancer 10.0 MME NCAM1
50 dependent personality disorder 10.0 KNTC1 MME

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:



Diseases related to Chronic Orbital Inflammation

Symptoms & Phenotypes for Chronic Orbital Inflammation

GenomeRNAi Phenotypes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased IL-8 secretion GR00386-A-2 9.5 CSF3 CTLA4 CYCS MME MUC1 NCAM1
2 Decreased viability GR00055-A-2 9.44 MUC1 NCAM1 PIK3C2A
3 Decreased viability GR00221-A-1 9.44 PIK3C2A
4 Decreased viability GR00221-A-2 9.44 PIK3C2A
5 Decreased viability GR00221-A-4 9.44 PIK3C2A
6 Decreased viability GR00240-S-1 9.44 PIK3C2A
7 Decreased viability GR00342-S-1 9.44 PIK3C2A
8 Decreased viability GR00342-S-2 9.44 PIK3C2A
9 Decreased viability GR00342-S-3 9.44 PIK3C2A
10 Decreased viability GR00402-S-2 9.44 MUC1 NCAM1 PIK3C2A

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CSF3 CTLA4 CYCS MME PIK3C2A PRTN3

Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

Genetic Tests for Chronic Orbital Inflammation

Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

41
Eye, Lung, Skin, Bone, Testis, T Cells, Myeloid

Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

# Title Authors Year
1
Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ( 29515429 )
2017
2
Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ( 18806668 )
2008

Variations for Chronic Orbital Inflammation

Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

Pathways for Chronic Orbital Inflammation

GO Terms for Chronic Orbital Inflammation

Cellular components related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.32 CTLA4 KNTC1 MME MRAP MUC1 NCAM1

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.02 CSF3 IFNA2 MUC1 PRTN3 TNFRSF1B

Sources for Chronic Orbital Inflammation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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