MCID: CHR093
MIFTS: 28

Chronic Orbital Inflammation

Categories: Eye diseases

Aliases & Classifications for Chronic Orbital Inflammation

MalaCards integrated aliases for Chronic Orbital Inflammation:

Name: Chronic Orbital Inflammation 12 15
Chronic Inflammation of Orbit 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1397
ICD10 33 H05.1
ICD9CM 35 376.1 376.10
UMLS 73 C0155261

Summaries for Chronic Orbital Inflammation

MalaCards based summary : Chronic Orbital Inflammation, also known as chronic inflammation of orbit, is related to scleral disease and iritis. An important gene associated with Chronic Orbital Inflammation is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. Affiliated tissues include eye, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Chronic Orbital Inflammation

Diseases in the Acute Orbital Inflammation family:

Chronic Orbital Inflammation

Diseases related to Chronic Orbital Inflammation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 scleral disease 10.8 MRAP TNFRSF1B
2 iritis 10.8 MRAP TNFRSF1B
3 pustulosis of palm and sole 10.8 MRAP TNFRSF1B
4 trichostrongylosis 10.8 CD79A PIK3C2A
5 tenosynovitis 10.7 MRAP TNFRSF1B
6 spastic paraplegia 32, autosomal recessive 10.7 FCGR3A FCGR3B
7 trichostrongyloidiasis 10.7 CD79A PIK3C2A
8 spinocerebellar ataxia, autosomal recessive 10 10.7 CD79A IFNA2
9 rheumatic myocarditis 10.7 FCGR3A FCGR3B
10 myxedema 10.7 CTLA4 TSHR
11 penile disease 10.7 IFNA2 MRAP
12 rheumatoid lung disease 10.6 MUC1 TNFRSF1B
13 sarcomatoid renal cell carcinoma 10.6 IFNA2 MUC1
14 phlebotomus fever 10.6 CD79A IFNA2
15 chorioretinitis 10.5 CD79A MRAP
16 cryptogenic organizing pneumonia 10.5 MUC1 PIK3C2A
17 ovarian cystic teratoma 10.5 FCGR3A FCGR3B IFNA2
18 urethritis 10.5 CD79A MRAP
19 mycosis fungoides 10.5 CTLA4 IFNA2 TNFRSF1B
20 pericoronitis 10.5 NCAM1 TNFRSF1B
21 granulomatous hepatitis 10.5 CD79A IFNA2 TNFRSF1B
22 poliomyelitis 10.5 FCGR3A FCGR3B
23 cervicitis 10.5 CD79A MRAP
24 posterior scleritis 10.4 MRAP PRTN3
25 hypopyon 10.4 MRAP NCAM1
26 diffuse infiltrative lymphocytosis syndrome 10.4 FCGR3A FCGR3B MRAP
27 anca-associated vasculitis 10.4 CTLA4 PRTN3
28 cervix disease 10.4 CD79A MRAP
29 sclerosing keratitis 10.4 CD79A PRTN3
30 peroneal neuropathy 10.4 MME TNFRSF1B
31 transient neonatal neutropenia 10.4 CD79A FCGR3A FCGR3B
32 acute salpingitis 10.4 CD79A MRAP TNFRSF1B
33 pleuropneumonia 10.4 CD79A FCGR3A FCGR3B
34 monoclonal paraproteinemia 10.4 CD79A PRTN3
35 hypersensitivity reaction type iv disease 10.4 CD79A MRAP TNFRSF1B
36 spondyloarthropathy 1 10.4 CD79A MRAP TNFRSF1B
37 intestinal disease 10.4 CD79A MRAP TNFRSF1B
38 parasitic ichthyosporea infectious disease 10.4 CD79A NCAM1
39 vulvitis 10.3 CD79A MRAP
40 rhinosporidiosis 10.3 CD79A NCAM1
41 ovarian serous cystadenofibroma 10.3 MUC1 NCAM1
42 precursor t-lymphoblastic lymphoma/leukemia 10.3 CD79A MME
43 encapsulated thymoma 10.3 CD79A MME
44 transitional meningioma 10.3 MUC1 NCAM1
45 precursor lymphoblastic lymphoma/leukemia 10.3 CD79A MME
46 myxopapillary ependymoma 10.3 MUC1 NCAM1
47 rapidly progressive glomerulonephritis 10.3 CD79A PRTN3
48 hypothyroidism 10.2 CTLA4 IFNA2 PIK3C2A TSHR
49 malignant skin fibrous histiocytoma 10.2 CTLA4 IFNA2 NCAM1
50 chronic nk-cell lymphocytosis 10.2 FCGR3A FCGR3B NCAM1

Graphical network of the top 20 diseases related to Chronic Orbital Inflammation:



Diseases related to Chronic Orbital Inflammation

Symptoms & Phenotypes for Chronic Orbital Inflammation

GenomeRNAi Phenotypes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.77 MUC1 NCAM1 PIK3C2A
2 Decreased viability GR00221-A-1 9.77 PIK3C2A
3 Decreased viability GR00221-A-2 9.77 PIK3C2A
4 Decreased viability GR00221-A-4 9.77 PIK3C2A
5 Decreased viability GR00240-S-1 9.77 PIK3C2A
6 Decreased viability GR00342-S-1 9.77 PIK3C2A
7 Decreased viability GR00342-S-2 9.77 PIK3C2A
8 Decreased viability GR00342-S-3 9.77 PIK3C2A
9 Decreased viability GR00402-S-2 9.77 PIK3C2A MUC1 NCAM1
10 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CD79A FCGR3A MME NCAM1 PIK3C2A

MGI Mouse Phenotypes related to Chronic Orbital Inflammation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CD79A CTLA4 CYCS FCGR3B MME PIK3C2A

Drugs & Therapeutics for Chronic Orbital Inflammation

Search Clinical Trials , NIH Clinical Center for Chronic Orbital Inflammation

Genetic Tests for Chronic Orbital Inflammation

Anatomical Context for Chronic Orbital Inflammation

MalaCards organs/tissues related to Chronic Orbital Inflammation:

41
Eye

Publications for Chronic Orbital Inflammation

Articles related to Chronic Orbital Inflammation:

# Title Authors Year
1
Chronic Orbital Inflammation Associated to Hydroxyapatite Implants in Anophthalmic Sockets. ( 29515429 )
2017
2
Chronic orbital inflammation and fibrosis after retrobulbar alcohol and chlorpromazine injections in a patient with choroidal melanoma. ( 18806668 )
2008

Variations for Chronic Orbital Inflammation

Expression for Chronic Orbital Inflammation

Search GEO for disease gene expression data for Chronic Orbital Inflammation.

Pathways for Chronic Orbital Inflammation

GO Terms for Chronic Orbital Inflammation

Cellular components related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.63 CD79A CTLA4 MME MUC1 TNFRSF1B TSHR
2 plasma membrane GO:0005886 9.44 CD79A CTLA4 FCGR3A FCGR3B KNTC1 MME
3 external side of plasma membrane GO:0009897 9.26 CD79A CTLA4 FCGR3A NCAM1

Biological processes related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.56 FCGR3B MME PRTN3 TNFRSF1B
2 cytokine-mediated signaling pathway GO:0019221 9.46 IFNA2 MUC1 PRTN3 TNFRSF1B
3 cell surface receptor signaling pathway GO:0007166 9.26 CD79A IFNA2 TNFRSF1B TSHR
4 B cell differentiation GO:0030183 8.8 CD79A IFNA2 TSHR

Molecular functions related to Chronic Orbital Inflammation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3A FCGR3B

Sources for Chronic Orbital Inflammation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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