MCID: CHR344
MIFTS: 18

Chronic Orthostatic Intolerance

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Orthostatic Intolerance

MalaCards integrated aliases for Chronic Orthostatic Intolerance:

Name: Chronic Orthostatic Intolerance 54

Classifications:



Summaries for Chronic Orthostatic Intolerance

NINDS : 54 Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. OI describes a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. The primary symptom of OI is lightheadedness or fainting. In POTS, the lightheadedness or fainting is also accompanied by a rapid increase in heartbeat of more than 30 beats per minute, or a heart rate that exceeds 120 beats per minute, within 10 minutes of rising. The faintness or lightheadedness of POTS are relieved by lying down again. Anyone at any age can develop POTS, but the majority of individuals affected (between 75 and 80 percent) are women between the ages of 15 to 50 years of age. Some women report an increase in episodes of POTS right before their menstrual periods. POTS often begins after a pregnancy, major surgery, trauma, or a viral illness. It may make individuals unable to exercise because the activity brings on fainting spells or dizziness. Doctors aren't sure yet what causes the reduced return of blood to the heart that occurs in OI, or why the heart begins to beat so rapidly in POTS.  Current thinking is that there are a number of mechanisms.  Some individuals have peripheral denervation (neuropathic POTS); some have symptoms that are due to sustained or parosyxmal overactivity of the sympathetic nervous system (hyperadrenergic POTS); and many individuals with POTS have significant deconditioning. 

MalaCards based summary : Chronic Orthostatic Intolerance is related to orthostatic intolerance and postural orthostatic tachycardia syndrome. The drugs Propranolol and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and spinal cord.

Related Diseases for Chronic Orthostatic Intolerance

Diseases in the Orthostatic Intolerance family:

Chronic Orthostatic Intolerance

Diseases related to Chronic Orthostatic Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 10.5
2 postural orthostatic tachycardia syndrome 10.0
3 syncope 10.0
4 dysautonomia 10.0

Symptoms & Phenotypes for Chronic Orthostatic Intolerance

Drugs & Therapeutics for Chronic Orthostatic Intolerance

Drugs for Chronic Orthostatic Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
2 Vasodilator Agents Phase 4,Phase 2,Phase 1
3 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 1
4 Adrenergic Antagonists Phase 4,Phase 2,Phase 1
5 Antihypertensive Agents Phase 4,Phase 2,Phase 1
6 Adrenergic Agents Phase 4,Phase 2,Phase 1
7 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
8 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
9
Racepinephrine Approved Phase 2 329-65-7 838
10
Norepinephrine Approved Phase 2 51-41-2 439260
11
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
12
Entacapone Approved, Investigational Phase 1, Phase 2 130929-57-6 5281081
13
Acetazolamide Approved, Vet_approved Phase 1, Phase 2 59-66-5 1986
14
AT-101 Approved, Investigational Phase 1, Phase 2 90141-22-3, 652-67-5 12597
15
Midodrine Approved Phase 1, Phase 2 133163-28-7, 42794-76-3 4195
16
Sertraline Approved Phase 1, Phase 2 79617-96-2 68617
17
Dopamine Approved Phase 1, Phase 2 51-61-6, 62-31-7 681
18
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
19
Mecamylamine Approved, Investigational Phase 1, Phase 2 60-40-2 4032
20
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
21
Isosorbide Dinitrate Approved, Investigational Phase 1, Phase 2 87-33-2 6883
22
Memantine Approved, Investigational Phase 1, Phase 2 19982-08-2 4054
23
Armodafinil Approved, Investigational Phase 1, Phase 2 112111-43-0
24
Octreotide Approved, Investigational Phase 1, Phase 2 83150-76-9 383414 6400441
25
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
26
Modafinil Approved, Investigational Phase 1, Phase 2 68693-11-8 4236
27
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
28 Epinephryl borate Phase 2
29 Dopamine Agents Phase 1, Phase 2
30 Analgesics, Non-Narcotic Phase 1, Phase 2
31 Antirheumatic Agents Phase 1, Phase 2
32 Sympathomimetics Phase 1, Phase 2
33 Vasoconstrictor Agents Phase 1, Phase 2
34 Antineoplastic Agents, Hormonal Phase 1, Phase 2
35 Excitatory Amino Acid Antagonists Phase 1, Phase 2
36 Atomoxetine Hydrochloride Phase 1, Phase 2
37 Antioxidants Phase 1, Phase 2
38 Anti-Inflammatory Agents Phase 1, Phase 2
39 Adrenergic alpha-Agonists Phase 1, Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
41 Peripheral Nervous System Agents Phase 1, Phase 2
42 isosorbide-5-mononitrate Phase 1, Phase 2
43 Cholinergic Agents Phase 1, Phase 2
44 Anticonvulsants Phase 1, Phase 2
45 Psychotropic Drugs Phase 1, Phase 2
46 Pharmaceutical Solutions Phase 1, Phase 2
47 Sympatholytics Phase 1, Phase 2
48 Nitric Oxide Donors Phase 1, Phase 2
49 Cholinergic Antagonists Phase 1, Phase 2
50 Catechol Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
2 Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance Completed NCT00093860 Phase 2 Propranolol
3 Treatment of Orthostatic Intolerance Active, not recruiting NCT00262470 Phase 1, Phase 2 Acetazolamide;Atomoxetine;Clonidine;Entacapone;Entacapone & Propranolol;Atomoxetine & Propranolol;Indomethacin;Mecamylamine;Isosorbide Dinitrate;Midodrine;Modafinil;Octreotide;Propranolol;Modafinil & Propranolol;Sertraline;memantine
4 Evaluation of Chronic Orthostatic Intolerance Completed NCT00069693
5 Objective Sleep Disturbances in Orthostatic Intolerance Completed NCT00581022
6 Hypnosis in Autonomic Function Completed NCT00061009
7 Acute Salt Handling in Orthostatic Intolerance Active, not recruiting NCT00581633 Not Applicable

Search NIH Clinical Center for Chronic Orthostatic Intolerance

Genetic Tests for Chronic Orthostatic Intolerance

Anatomical Context for Chronic Orthostatic Intolerance

MalaCards organs/tissues related to Chronic Orthostatic Intolerance:

41
Heart, Testes, Spinal Cord

Publications for Chronic Orthostatic Intolerance

Articles related to Chronic Orthostatic Intolerance:

(show all 11)
# Title Authors Year
1
Neurocirculatory abnormalities in chronic orthostatic intolerance. ( 15699262 )
2005
2
Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS). ( 15580191 )
2004
3
Altered profile of baroreflex and autonomic responses to lower body negative pressure in chronic orthostatic intolerance. ( 15257177 )
2004
4
Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope. ( 12653674 )
2003
5
Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects. ( 12010910 )
2002
6
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes. ( 12403667 )
2002
7
Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance. ( 12460877 )
2002
8
Inappropriate early hypotension in adolescents: a form of chronic orthostatic intolerance with defective dependent vasoconstriction. ( 11420425 )
2001
9
Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. ( 11007589 )
2000
10
Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. ( 9815870 )
1998
11
Chronic orthostatic intolerance: part of a spectrum of dysfunction in orthostatic cardiovascular homeostasis? ( 9815863 )
1998

Variations for Chronic Orthostatic Intolerance

Expression for Chronic Orthostatic Intolerance

Search GEO for disease gene expression data for Chronic Orthostatic Intolerance.

Pathways for Chronic Orthostatic Intolerance

GO Terms for Chronic Orthostatic Intolerance

Sources for Chronic Orthostatic Intolerance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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