MCID: CHR344
MIFTS: 17

Chronic Orthostatic Intolerance

Categories: Cardiovascular diseases, Genetic diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Orthostatic Intolerance

MalaCards integrated aliases for Chronic Orthostatic Intolerance:

Name: Chronic Orthostatic Intolerance 55

Classifications:



Summaries for Chronic Orthostatic Intolerance

NINDS : 55 Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. OI describes a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. The primary symptom of OI is lightheadedness or fainting. In POTS, the lightheadedness or fainting is also accompanied by a rapid increase in heartbeat of more than 30 beats per minute, or a heart rate that exceeds 120 beats per minute, within 10 minutes of rising. The faintness or lightheadedness of POTS are relieved by lying down again. Anyone at any age can develop POTS, but the majority of individuals affected (between 75 and 80 percent) are women between the ages of 15 to 50 years of age. Some women report an increase in episodes of POTS right before their menstrual periods. POTS often begins after a pregnancy, major surgery, trauma, or a viral illness. It may make individuals unable to exercise because the activity brings on fainting spells or dizziness. Doctors aren't sure yet what causes the reduced return of blood to the heart that occurs in OI, or why the heart begins to beat so rapidly in POTS.  Current thinking is that there are a number of mechanisms.  Some individuals have peripheral denervation (neuropathic POTS); some have symptoms that are due to sustained or parosyxmal overactivity of the sympathetic nervous system (hyperadrenergic POTS); and many individuals with POTS have significant deconditioning. 

MalaCards based summary : Chronic Orthostatic Intolerance is related to orthostatic intolerance and postural orthostatic tachycardia syndrome. The drugs Propranolol and Adrenergic Antagonists have been mentioned in the context of this disorder. Affiliated tissues include heart.

Related Diseases for Chronic Orthostatic Intolerance

Diseases in the Orthostatic Intolerance family:

Chronic Orthostatic Intolerance

Diseases related to Chronic Orthostatic Intolerance via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 orthostatic intolerance 10.5
2 postural orthostatic tachycardia syndrome 10.0
3 syncope 10.0
4 dysautonomia 10.0

Symptoms & Phenotypes for Chronic Orthostatic Intolerance

Drugs & Therapeutics for Chronic Orthostatic Intolerance

Drugs for Chronic Orthostatic Intolerance (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
2 Adrenergic Antagonists Phase 4,Phase 2,Phase 1
3 Vasodilator Agents Phase 4,Phase 2,Phase 1
4 Adrenergic beta-Antagonists Phase 4,Phase 2,Phase 1
5 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1
6 Neurotransmitter Agents Phase 4,Phase 2,Phase 1
7 Adrenergic Agents Phase 4,Phase 2,Phase 1
8 Antihypertensive Agents Phase 4,Phase 2,Phase 1
9
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
10
Racepinephrine Approved Phase 2 329-65-7 838
11
Norepinephrine Approved Phase 2 51-41-2 439260
12
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
13
Dopamine Approved Phase 1, Phase 2 62-31-7, 51-61-6 681
14
Mecamylamine Approved, Investigational Phase 1, Phase 2 60-40-2 4032
15
Octreotide Approved, Investigational Phase 1, Phase 2 83150-76-9 6400441 383414
16
Sertraline Approved Phase 1, Phase 2 79617-96-2 68617
17
AT-101 Approved, Investigational Phase 1, Phase 2 90141-22-3, 652-67-5 12597
18
Entacapone Approved, Investigational Phase 1, Phase 2 130929-57-6 5281081
19
Memantine Approved, Investigational Phase 1, Phase 2 19982-08-2 4054
20
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
21
Acetazolamide Approved, Vet_approved Phase 1, Phase 2 59-66-5 1986
22
Indomethacin Approved, Investigational Phase 1, Phase 2 53-86-1 3715
23
Midodrine Approved Phase 1, Phase 2 133163-28-7, 42794-76-3 4195
24
Modafinil Approved, Investigational Phase 1, Phase 2 68693-11-8 4236
25
Isosorbide Dinitrate Approved, Investigational Phase 1, Phase 2 87-33-2 6883
26
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
27 Epinephryl borate Phase 2
28 Dopamine Agents Phase 1, Phase 2
29 Antioxidants Phase 1, Phase 2
30 Atomoxetine Hydrochloride Phase 1, Phase 2
31 Antidepressive Agents Phase 1, Phase 2
32 Central Nervous System Depressants Phase 1, Phase 2
33 Neurotransmitter Uptake Inhibitors Phase 1, Phase 2
34 Peripheral Nervous System Agents Phase 1, Phase 2
35 Anti-Inflammatory Agents Phase 1, Phase 2
36 Excitatory Amino Acid Antagonists Phase 1, Phase 2
37 Tocolytic Agents Phase 1, Phase 2
38 Nitric Oxide Donors Phase 1, Phase 2
39 Psychotropic Drugs Phase 1, Phase 2
40 Autonomic Agents Phase 1, Phase 2
41 Antiparkinson Agents Phase 1, Phase 2
42 Carbonic Anhydrase Inhibitors Phase 1, Phase 2
43 Cholinergic Agents Phase 1, Phase 2
44 Cholinergic Antagonists Phase 1, Phase 2
45 Cyclooxygenase Inhibitors Phase 1, Phase 2
46 Natriuretic Agents Phase 1, Phase 2
47 Vasoconstrictor Agents Phase 1, Phase 2
48 Adrenergic Agonists Phase 1, Phase 2
49 Sympathomimetics Phase 1, Phase 2
50 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Propranolol to Treat Fainting Due to Sympathoadrenal Imbalance Completed NCT00060866 Phase 4 Propranolol
2 Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance Completed NCT00093860 Phase 2 Propranolol
3 Treatment of Orthostatic Intolerance Active, not recruiting NCT00262470 Phase 1, Phase 2 Acetazolamide;Atomoxetine;Clonidine;Entacapone;Entacapone & Propranolol;Atomoxetine & Propranolol;Indomethacin;Mecamylamine;Isosorbide Dinitrate;Midodrine;Modafinil;Octreotide;Propranolol;Modafinil & Propranolol;Sertraline;memantine
4 Evaluation of Chronic Orthostatic Intolerance Completed NCT00069693
5 Objective Sleep Disturbances in Orthostatic Intolerance Completed NCT00581022
6 Hypnosis in Autonomic Function Completed NCT00061009
7 Acute Salt Handling in Orthostatic Intolerance Active, not recruiting NCT00581633 Not Applicable

Search NIH Clinical Center for Chronic Orthostatic Intolerance

Genetic Tests for Chronic Orthostatic Intolerance

Anatomical Context for Chronic Orthostatic Intolerance

MalaCards organs/tissues related to Chronic Orthostatic Intolerance:

42
Heart

Publications for Chronic Orthostatic Intolerance

Articles related to Chronic Orthostatic Intolerance:

(show all 11)
# Title Authors Year
1
Neurocirculatory abnormalities in chronic orthostatic intolerance. ( 15699262 )
2005
2
Altered profile of baroreflex and autonomic responses to lower body negative pressure in chronic orthostatic intolerance. ( 15257177 )
2004
3
Chronic orthostatic intolerance and the postural tachycardia syndrome (POTS). ( 15580191 )
2004
4
Contrasting neurovascular findings in chronic orthostatic intolerance and neurocardiogenic syncope. ( 12653674 )
2003
5
Pooling in chronic orthostatic intolerance: arterial vasoconstrictive but not venous compliance defects. ( 12010910 )
2002
6
Cardiac sympathetic dysautonomia in chronic orthostatic intolerance syndromes. ( 12403667 )
2002
7
Clinical and physiological effects of an acute alpha-1 adrenergic agonist and a beta-1 adrenergic antagonist in chronic orthostatic intolerance. ( 12460877 )
2002
8
Inappropriate early hypotension in adolescents: a form of chronic orthostatic intolerance with defective dependent vasoconstriction. ( 11420425 )
2001
9
Vascular perturbations in the chronic orthostatic intolerance of the postural orthostatic tachycardia syndrome. ( 11007589 )
2000
10
Chronic orthostatic intolerance: part of a spectrum of dysfunction in orthostatic cardiovascular homeostasis? ( 9815863 )
1998
11
Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. ( 9815870 )
1998

Variations for Chronic Orthostatic Intolerance

Expression for Chronic Orthostatic Intolerance

Search GEO for disease gene expression data for Chronic Orthostatic Intolerance.

Pathways for Chronic Orthostatic Intolerance

GO Terms for Chronic Orthostatic Intolerance

Sources for Chronic Orthostatic Intolerance

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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