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MCID: CHR345
MIFTS: 50

Chronic Pain

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Pain

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MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 53 29 6 42
Pain - Chronic 53

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Chronic Pain

About this section
NINDS : 53 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to fibromyalgia and opioid addiction. An important gene associated with Chronic Pain is USH2A (Usherin), and among its related pathways/superpathways are GABAergic synapse and Neuroscience. The drugs Dinoprostone and Methadone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cortex and dorsal root ganglion, and related phenotypes are integument and nervous system

MedlinePlus : 42 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 73 Chronic pain is classified as pain that lasts longer than three to six months. In medicine, the... more...

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Related Diseases for Chronic Pain

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Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 591)
# Related Disease Score Top Affiliating Genes
1 fibromyalgia 31.4 PNOC OPRM1 IL10 COMT
2 opioid addiction 31.2 PNOC OPRM1 COMT
3 chronic fatigue syndrome 31.1 P2RX4 IL10 COMT
4 substance abuse 31.1 OPRM1 COMT CNR1
5 paine syndrome 31.1 PNOC P2RX3 OPRM1 COMT
6 constipation 30.9 PTGS2 OPRM1 CNR1
7 opioid abuse 30.7 PNOC OPRM1
8 eating disorder 30.2 OPRM1 COMT CNR1
9 anxiety 30.2 USH2A PNOC OPRM1 COMT CNR1
10 somatoform disorder 30.2 P2RX3 OPRM1 COMT
11 drug dependence 30.1 PNOC OPRM1 CNR1
12 cannabis dependence 30.1 COMT CNR1
13 cannabis abuse 30.1 COMT CNR1
14 autonomic dysfunction 30.0 USH2A CPT2
15 polysubstance abuse 29.9 COMT CNR1
16 alcohol dependence 29.9 PNOC OPRM1 COMT CNR1
17 substance dependence 29.9 OPRM1 IL10 COMT CNR1
18 withdrawal disorder 29.8 PNOC OPRM1 CNR1
19 pain agnosia 29.8 PTGS2 PNOC P2RX3 OPRM1 COMT CNR1
20 morphine dependence 29.7 PTGS2 OPRM1
21 arthritis 29.7 PTGS2 OPRM1 IL10 CPT2
22 dysautonomia 29.6 USH2A CPT2
23 heroin dependence 29.5 OPRM1 COMT
24 neonatal abstinence syndrome 29.2 PNOC OPRM1 COMT
25 migraine with or without aura 1 28.7 PTGS2 PNOC P2RX4 P2RX3 OPRM1 IL10
26 disease of mental health 28.4 PTGS2 PNOC P2RX4 P2RX3 OPRM1 IL10
27 complex regional pain syndrome 11.2
28 hidradenitis suppurativa 11.1
29 trigeminal neuralgia 11.1
30 melorheostosis 11.0
31 headache 11.0
32 ehlers-danlos syndrome 11.0
33 interstitial cystitis 11.0
34 sickle cell disease 11.0
35 amyotrophy, hereditary neuralgic 11.0
36 corticosteroid-binding globulin deficiency 11.0
37 reflex sympathetic dystrophy 10.9
38 myofascial pain syndrome 10.9
39 rheumatoid arthritis 10.9
40 causalgia 10.9
41 back pain 10.9
42 osteoporosis 10.9
43 occipital neuralgia 10.9
44 stiff-person syndrome 10.8
45 cauda equina syndrome 10.8
46 exostosis 10.8
47 medullary sponge kidney 10.8
48 adiposis dolorosa 10.8
49 brachyolmia type 3 10.8
50 buschke-ollendorff syndrome 10.8

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain
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Symptoms & Phenotypes for Chronic Pain

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MGI Mouse Phenotypes related to Chronic Pain:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.5 CACNA1B CNR1 IL10 OPRM1 P2RX3 PNOC
2 nervous system MP:0003631 9.28 CACNA1B CNR1 COMT IL10 OPRM1 P2RX3
Sources

Drugs & Therapeutics for Chronic Pain

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Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 392)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dinoprostone Approved Phase 4 363-24-6 5280360
2
Methadone Approved Phase 4 76-99-3 4095
3
Amitriptyline Approved Phase 4 50-48-6 2160
4
Perphenazine Approved Phase 4 58-39-9 4748
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
8
Flunarizine Approved Phase 4 52468-60-7 941361
9
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
10
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
11
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
12
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
13
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
14
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
15
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
16
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
17
Carbidopa Approved Phase 4 28860-95-9 34359
18
Levodopa Approved Phase 4 59-92-7 6047
19
Ondansetron Approved Phase 4 99614-02-5 4595
20
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
21
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
23
Desipramine Approved, Investigational Phase 4 50-47-5 2995
24
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
25
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
26
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
27
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
28
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
29
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
30
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
31
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
32
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
33
Phenol Approved, Experimental Phase 4 108-95-2 996
34
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
35
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
36
Polyestradiol phosphate Approved Phase 4 28014-46-2
37
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
38
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
39
Iodine Approved, Investigational Phase 4 7553-56-2 807
40
Opium Approved, Illicit Phase 4 8008-60-4
41
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
42
Benzyl alcohol Approved Phase 4 100-51-6 244
43
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-56-5 148211
44
Methocarbamol Approved, Vet_approved Phase 4 532-03-6 4107
45
Ferrous fumarate Approved Phase 4 141-01-5
46
Norethindrone Approved Phase 4 68-22-4 6230
47
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
48
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
49
Ibuprofen Approved Phase 4 15687-27-1 3672
50
Dopamine Approved Phase 4 62-31-7, 51-61-6 681

Interventional clinical trials:

(show top 50) (show all 1900)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Dexamethasone Versus Betamethasone Epidural Caudal Administration for Treatment of Lumbosacral Radiculalgia: Randomized Clinical Trial Unknown status NCT02833116 Phase 4 Betamethasone;Dexamethasone
2 Effects of Intraoperative Intravenous Ketamine on Chronic Pain After Mastectomy Unknown status NCT02729805 Phase 4 Saline;Ketamine 0.5mg/kg;Ketamine 0.75mg/kg
3 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
4 The Role of Intra-operative Lidocaine Infusion in Preventing Chronic Post Surgical Pain After Video Assisted Thoracoscopic Surgery Unknown status NCT02862769 Phase 4 Lidocaine;Saline
5 Safety and Efficacy of Medical Cannabis Oil in the Treatment of Patients With Chronic Pain: A Randomized, Double-Blind, Placebo-Controlled Pilot Study, Followed by an Open-Label Extension Phase Unknown status NCT03337503 Phase 4 THC and CDB in a 1 to 1 ratio;Experimental: THC and CBD in a 1 to 2 ratio;High CBD with trace THC oil
6 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
7 Brain Mechanisms For Clinical Placebo in Chronic Pain: A Randomized Clinical Trial of Placebo, Active Treatment, and No Treatment in Chronic Back Pain Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
8 Investigator Initiated Trial- Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty. Comparison of Spinal Cord Stimulation and Comprehensive Medical Management Unknown status NCT01616342 Phase 4
9 Low Dose Intraoperative Intravenous Ketamine in Combination With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain: a Randomized Study Unknown status NCT03280017 Phase 4 Ketamine;Normal saline
10 Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting Unknown status NCT03450161 Phase 4 Fentanyl dosing schemes
11 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
12 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
13 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
14 Effect of Nicotine on Chronic Pelvic Pain Completed NCT00440505 Phase 4 Placebo;Nicotine (5 mg);Nicotine (10 mg)
15 Octad Study: Evaluation of the Effectiveness of the Octopolar Lead in Patients With Failed Back Surgery Syndrome With Low Back and/or Leg Pain During a One Year Follow-up Period Completed NCT01096147 Phase 4
16 Phase 4 Study of Prevention of Persistent Postsurgical Pain After Thoracotomy Using Ketamine Completed NCT01243801 Phase 4 Ketamine
17 Effect of Extended-release Oxymorphone Hydrochloride (Opana® ER), Taken Fasting Versus With Food, on Cognitive Functioning in Opioid-tolerant Subjects: a Randomized, Single-blinded, Cross-over Study Completed NCT00930943 Phase 4 Oxymorphone ER (Opana ER)
18 Early and Late Results of Transinguinal Preperitoneal Patch Repair Versus Anterior Pre-Trasversalis Mesh Repair. A Randomised Study Completed NCT01350830 Phase 4
19 A Randomised Placebo-controlled Trail of Mechanical and Cold Hyperalgesia in Subjects With Painful Knee Osteoarthritis, Compared With Matched Controls, & Whether This Hyperalgesia Can be Modified by a 2-week Course of Etoricoxib 60mg. Completed NCT00927004 Phase 4 Etoricoxib (Arcoxia);Sugar pill
20 A Randomized Controlled Trial Comparing Buprenorphine and Methadone for Treatment in Opioid Dependent Chronic Back Pain Patients Completed NCT01559454 Phase 4 Methadone;Buprenorphine/naloxone
21 Multicentre Study To Evaluate Efficacy And Safety Of Buprenorphine Transdermal Patch (Norspan) In Chronic Non-Malignant Pain Of Moderate To Severe Intensity Due To Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain And Joint / Muscle Pain, When Opioid Is Needed For Analgesia Completed NCT01961271 Phase 4 Buprenorphine transdermal patch
22 Management of Chronic Pain in Rehabilitation Project I - Management of Chronic Pain in Persons With Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
23 Management of Chronic Pain in Rehabilitation Project II Management of Chronic Pain in Persons With Amputation Completed NCT00006427 Phase 4 Amitriptyline
24 Prospective Randomized Controlled Trial Comparing Conservative Therapies for the Alleviation of Knee Pain in Knee Osteoarthritis Completed NCT02320500 Phase 4
25 Investigation of the Use of Remote Presence Robots in the Administration of Neuromodulation Treatment Completed NCT01283633 Phase 4
26 An Interventional Study to Compare the Efficacy and Tolerability of Current and Slow Titration With Targin® in the Treatment of Moderate to Severe Non-malignant Chronic Pain (GLORY) Completed NCT01811186 Phase 4 Oxycodone/naloxone
27 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
28 Effects of Amitriptyline on Central Pain Processing in Healthy Volunteers Depending on CYP Pharmacogenetics Completed NCT02256943 Phase 4 Amitriptyline;Tolterodine
29 Neurologic Signatures of Chronic Pain Disorders Completed NCT02747940 Phase 4 flunarizine and/or pregabalin
30 Evaluation Study of Efficacy and Safety of TTS-Fentanyl in Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
31 Pilot Study: Extended Regional Anesthesia to Prevent Chronic Pain After Ankle Fracture Surgery Completed NCT02950558 Phase 4 Ropivacaine
32 A CTSC Clinical Research Center Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
33 Pharmacokinetics of Intravenous Oxytocin and Effects on Sensory Function in Healthy Volunteers Completed NCT03929367 Phase 4 Oxytocin
34 Single Blinded, Randomized Control Trial of High Frequency Stimulation in Subjects With Precision® Spinal Cord Stimulator System to Assess Efficacy and Preferability in Back and Extremity Pain Relief Completed NCT02265848 Phase 4
35 Effectiveness of the Precision Spinal Cord Stimulation System in Patients With Failed Back Surgery Syndrome and Axial Low Back Pain Completed NCT00205868 Phase 4
36 Observational Registry: The Effectiveness of Pain Management Using the ARCHIMEDES® Implantable Constant-Flow Infusion Pump System for Intrathecal Delivery Completed NCT00196053 Phase 4
37 Evaluation in Efficacy and Safety of Fentanyl-TTS (Durogesic® D-Trans) for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
38 Effects of Intramuscular Oxytocin on Sensory Function in Healthy Volunteers With Ultraviolet Burn Injury to the Skin Completed NCT03935399 Phase 4 Oxytocin;Saline
39 Effects of Amitriptyline on Central Pain Processing in Healthy Volunteers Depending on CYP Pharmacogenetics Completed NCT02256956 Phase 4 Amitriptyline;Tolterodine
40 Benefit of Laparoscopic Adhesiolysis Completed NCT02839564 Phase 4
41 A Comparison of the Efficacy of High Intensity Laser and Ultrasound Therapies in Patients With Chronic Shoulder Pain: A Randomized Controlled Single Blind Study Completed NCT02793401 Phase 4
42 Liposomal Bupivacaine Versus Bupivacaine With Fascia Iliaca Blockade for Perioperative Pain Management During Hip Arthroscopy: A Double-Blinded Prospective Randomized Control Trial Completed NCT02947178 Phase 4 Bupivacaine;Liposomal Bupivacaine
43 A Prospective, Randomized, Double Blinded, Placebo Controlled Pilot Study Assessing the Effect of Perioperative Pregabalin on the Incidence of Chronic Post Thoracotomy Pain Syndrome Completed NCT00663962 Phase 4 Pregabalin;Placebo
44 Evaluating the Pharmacokinetic Profile of Hydromorphone in Chronic Pain Patients Taking Hydrocodone/APAP Completed NCT01517295 Phase 4 Hydrocodone
45 Effects of Chronic Musculoskeletal Pain and Opioidergic Versus Placebo Interventions on Neuroendocrine Function in Men Completed NCT00737737 Phase 4 MS Contin;Placebo
46 N-of-1 Randomised Trials to Assess the Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Completed NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
47 Intra-Articular 0.5 % Lidocaine Injection Under Ultrasound Guidance in Chronic Knee Pain Due To Osteoarthritis Completed NCT02632565 Phase 4 Lidocaine;Saline
48 A Randomised Clinical Trial Evaluating the Effect of Remifentanil vs Fentanyl During Cardiac Surgery on the Incidence of Chronic Thoracic Pain Completed NCT02031016 Phase 4 Fentanyl;Remifentanil;Fentanyl
49 Management of Neuropathic Chronic Pain With Methadone Combined With Ketamine: Randomized, Double Blind, Active-controlled Clinical Trial Completed NCT02233452 Phase 4 Methadone;Ketamine;Methadone plus Ketamine
50 Effects of Thoracic Paravertebral Blockade on Acute and Chronic Pain After Video Assisted Thoracoscopic Surgery (VATS) - A Randomized, Clinical Trial Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)

Search NIH Clinical Center for Chronic Pain

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Genetic Tests for Chronic Pain

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Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 29
Sources

Anatomical Context for Chronic Pain

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MalaCards organs/tissues related to Chronic Pain:

40
Spinal Cord, Cortex, Dorsal Root Ganglion, Brain, Cingulate Cortex, Eye, Prefrontal Cortex
Sources

Publications for Chronic Pain

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Articles related to Chronic Pain:

(show top 50) (show all 30543)
# Title Authors PMID Year
1
The relationships among self-efficacy, social support, and self-care behavior in the elderly patients with chronic pain (a STROBE-compliant article). 61 42
33655921 2021
2
Integrated cognitive behavioral therapy for chronic pain: An open-labeled prospective single-arm trial. 42 61
33578513 2021
3
The efficiency and safety of manual therapy for cervicogenic cephalic syndrome (CCS): A systematic review and meta-analysis. 42
33663133 2021
4
Spinal AMPA receptors: Amenable players in central sensitization for chronic pain therapy? 61
33565904 2021
5
Epigenetic control of ion channel expression and cell-specific splicing in nociceptors: Chronic pain mechanisms and potential therapeutic targets. 61
33323031 2021
6
Changes in peripheral HCN2 channels during persistent inflammation. 61
33423595 2021
7
Functional modulation of the human voltage-gated sodium channel NaV1.8 by auxiliary β subunits. 61
33315536 2021
8
Cortical plasticity and nerve regeneration after peripheral nerve injury. 61
33433465 2021
9
Food insecurity, chronic pain, and use of prescription opioids. 61
33763516 2021
10
Adrenergic signalling in osteoarthritis. 61
33571663 2021
11
An assembly of galanin-galanin receptor signaling network. 61
33136286 2021
12
Tobacco use severity in relation to opioid misuse and dependence among adult tobacco users with chronic pain: The moderating role of pain-related anxiety. 61
33545622 2021
13
Emotional awareness and other emotional processes: implications for the assessment and treatment of chronic pain. 61
33533272 2021
14
Virtual reality for acute and chronic pain management in adult patients: a narrative review. 61
32720308 2021
15
Pain Mechanisms in Patients with Rheumatic Diseases. 61
33781486 2021
16
Provider specialty and odds of a new codeine, hydrocodone, oxycodone and tramadol prescription before and after the CDC opioid prescribing guideline publication. 61
33636196 2021
17
A review of the StimRouter® peripheral neuromodulation system for chronic pain management. 61
33291992 2021
18
Development of depression-like behavior and altered hippocampal neurogenesis in a mouse model of chronic neuropathic pain. 61
33539793 2021
19
Unmet needs in the management of functional impairment in patients with chronic pain: a multinational survey. 61
33353407 2021
20
Low Back Pain in Adolescent and Geriatric Populations. 61
33781487 2021
21
Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain. 61
32989649 2021
22
HEME: a neglected player in nociception? 61
33545213 2021
23
A measure of expectancies for alcohol analgesia: Preliminary factor analysis, reliability, and validity. 61
33460990 2021
24
Metabolically stable neurotensin analogs exert potent and long-acting analgesia without hypothermia. 61
33607165 2021
25
Blood pressure as a predictor of everyday cognitive function in aging adults with and without fibromyalgia. 61
32339069 2021
26
Resilience, pain, and the brain: Relationships differ by sociodemographics. 61
33606287 2021
27
Beyond therapy types: Mindful self-compassion and the future of process-based therapy for chronic pain. 61
33534921 2021
28
Evaluation of the Arabic version of the Chronic Pain Grade scale: Psychometric properties. 61
33586152 2021
29
Drugs for chronic pain: we still need them. 61
33771795 2021
30
Prevalence of chronic pain after spinal cord injury: a systematic review and meta-analysis. 61
33408161 2021
31
Longitudinal Narrative Analysis of Parent Experiences During Graded Exposure Treatment for Children With Chronic Pain. 61
33555695 2021
32
Systematic Review of Autonomic Nervous System Functioning in Pediatric Chronic Pain. 61
33656000 2021
33
Brief Psychological Interventions for Reducing Prescription Opioid Use, Related Harm, and Pain Intensity in Patients With Chronic Pain: A Systematic Review and Assessment of Patient Interest. 61
33323791 2021
34
Pharmacogenetic testing: Clinical integration and application for chronic pain management. 61
33739321 2021
35
[Interdisciplinary position paper: the value of radiofrequency denervation in the treatment of chronic pain]. 61
33447917 2021
36
Pharmacogenetic testing: Clinical integration and application for chronic pain management. 61
33739322 2021
37
Gene expression profiling of the spinal cord at the chronic pain phase identified CDKL5 as a candidate gene for neural remodeling. 61
33636287 2021
38
Mindful Self-Compassion program for chronic pain patients: A randomized controlled trial. 61
33471404 2021
39
Incorporating walking into cognitive behavioral therapy for chronic pain: safety and effectiveness of a personalized walking intervention. 61
33386530 2021
40
[Medical pain care for children and adolescents with chronic pain in Germany : An inventory]. 61
33112976 2021
41
[Chronic pain in children and adolescents : The silent epidemic]. 61
33770248 2021
42
The quality of subgroup analyses in chronic pain randomized controlled trials: a methodological review. 61
33785666 2021
43
The impact of combining pain education strategies with physical therapy interventions for patients with chronic pain: A systematic review and meta-analysis of randomized controlled trials. 61
31250682 2021
44
[Diagnostics and therapy in children and adolescents with chronic pain : Trends in interventions potentially dangerous to health]. 61
33185762 2021
45
A Critical Review of the Social and Behavioral Contributions to the Overdose Epidemic. 61
33256535 2021
46
Battlefield Acupuncture as a Treatment for Pain. 61
33787939 2021
47
Child pain-related injustice appraisals mediate the relationship between just-world beliefs and pain-related functioning. 61
33259693 2021
48
Stimulant use for self-management of pain among safety-net patients with chronic non-cancer pain. 61
33798030 2021
49
A selective delta opioid receptor agonist SNC80, but not KNT-127, induced tremor-like behaviors via hippocampal glutamatergic system in mice. 61
33516811 2021
50
Dioxotriazine derivatives as a new class of P2X3 receptor antagonists: Identification of a lead and initial SAR studies. 61
33540044 2021
Sources

Variations for Chronic Pain

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ClinVar genetic disease variations for Chronic Pain:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CPT2 NM_000098.3(CPT2):c.149C>A (p.Pro50His) SNV Pathogenic 8954 rs28936375 GRCh37: 1:53662764-53662764
GRCh38: 1:53197092-53197092
2 USH2A NM_007123.5(USH2A):c.2299del (p.Glu767fs) Deletion Pathogenic 2351 rs80338903 GRCh37: 1:216420437-216420437
GRCh38: 1:216247095-216247095
3 MYH8 , MYHAS NM_002472.3(MYH8):c.5743A>G (p.Ile1915Val) SNV Uncertain significance 598988 rs1216879928 GRCh37: 17:10293842-10293842
GRCh38: 17:10390525-10390525
4 USH2A-AS2 , USH2A NM_206933.3(USH2A):c.5003G>T (p.Gly1668Val) SNV Uncertain significance 598989 rs1265349835 GRCh37: 1:216258204-216258204
GRCh38: 1:216084862-216084862
Sources

Expression for Chronic Pain

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Search GEO for disease gene expression data for Chronic Pain.
Sources

Pathways for Chronic Pain

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Pathways related to Chronic Pain according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
GABAergic synapse 36
Show member pathways
 11.77 PTGS2 OPRM1 CNR1 CACNA1B
2
Neuroscience 4
11.56 PTGS2 P2RX4 OPRM1 COMT CNR1
3
Interleukin-4 and 13 signaling 65
11.39 PTGS2 OPRM1 IL10
4
Ibuprofen Pathway, Pharmacodynamics 60
10.7 PTGS2 CNR1
Sources

GO Terms for Chronic Pain

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Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.71 PNOC P2RX4 OPRM1 COMT
2 neuronal cell body GO:0043025 9.62 USH2A PNOC P2RX4 P2RX3
3 dendritic spine GO:0043197 9.54 P2RX4 P2RX3 COMT
4 terminal bouton GO:0043195 9.33 USH2A P2RX4 P2RX3
5 integral component of nuclear inner membrane GO:0005639 9.26 P2RX4 P2RX3
6 integral component of presynaptic membrane GO:0099056 9.13 P2RX3 OPRM1 CNR1
7 axon GO:0030424 9.02 P2RX4 P2RX3 OPRM1 COMT CNR1

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.77 PTGS2 IL10 CNR1
2 calcium ion transmembrane transport GO:0070588 9.73 P2RX4 OPRM1 CACNA1B
3 response to organic substance GO:0010033 9.65 PTGS2 P2RX3 IL10
4 response to radiation GO:0009314 9.61 PTGS2 OPRM1
5 response to morphine GO:0043278 9.61 OPRM1 CNR1
6 neuronal action potential GO:0019228 9.59 P2RX4 P2RX3
7 membrane depolarization GO:0051899 9.58 P2RX4 CACNA1B
8 negative regulation of nitric oxide biosynthetic process GO:0045019 9.58 OPRM1 IL10
9 excitatory postsynaptic potential GO:0060079 9.58 P2RX4 P2RX3 OPRM1
10 response to ATP GO:0033198 9.57 P2RX4 P2RX3
11 inorganic cation transmembrane transport GO:0098662 9.55 P2RX4 P2RX3
12 positive regulation of calcium-mediated signaling GO:0050850 9.54 P2RX4 P2RX3
13 positive regulation of calcium ion transport into cytosol GO:0010524 9.52 P2RX4 P2RX3
14 sensory perception GO:0007600 9.51 PNOC OPRM1
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 PTGS2 P2RX4 OPRM1
16 behavioral response to pain GO:0048266 9.49 P2RX4 P2RX3
17 purinergic nucleotide receptor signaling pathway GO:0035590 9.46 P2RX4 P2RX3
18 positive regulation of sensory perception of pain GO:1904058 9.43 P2RX3 ATPSCKMT
19 regulation of sensory perception of pain GO:0051930 9.43 OPRM1 IL10 COMT
20 positive regulation of fever generation GO:0031622 9.37 PTGS2 CNR1
21 response to lipopolysaccharide GO:0032496 9.35 PTGS2 OPRM1 IL10 COMT CNR1
22 cellular response to ATP GO:0071318 9.33 PTGS2 P2RX4 P2RX3
23 sensory perception of pain GO:0019233 8.92 PTGS2 P2RX4 OPRM1 CNR1

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.33 P2RX4 P2RX3 CACNA1B
2 extracellularly ATP-gated cation channel activity GO:0004931 8.96 P2RX4 P2RX3
3 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX4 P2RX3
Sources

Sources for Chronic Pain

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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