MCID: CHR345
MIFTS: 50

Chronic Pain

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Chronic Pain

MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 53 29 6 42
Pain - Chronic 53

Classifications:



Summaries for Chronic Pain

NINDS : 53 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to paine syndrome and opioid addiction. An important gene associated with Chronic Pain is USH2A (Usherin), and among its related pathways/superpathways are GABAergic synapse and Neuroscience. The drugs Cycloserine and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and breast, and related phenotypes are behavior/neurological and integument

MedlinePlus : 42 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Related Diseases for Chronic Pain

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 591)
# Related Disease Score Top Affiliating Genes
1 paine syndrome 31.5 OPRM1 COMT
2 opioid addiction 31.4 OPRM1 COMT
3 pain agnosia 30.5 PTGS2 OPRM1 CNR1
4 constipation 30.1 PTGS2 OPRM1 CNR1
5 substance abuse 30.0 OPRM1 COMT CNR1
6 anxiety 29.7 USH2A OPRM1 COMT CNR1
7 irritable bowel syndrome 29.7 OPRM1 COMT CNR1
8 cannabis dependence 29.7 COMT CNR1
9 withdrawal disorder 29.6 OPRM1 CNR1
10 polysubstance abuse 29.5 COMT CNR1
11 disease of mental health 29.4 OPRM1 COMT CNR1
12 migraine with or without aura 1 29.2 PTGS2 OPRM1 COMT CNR1 CACNA1B
13 substance dependence 29.2 OPRM1 COMT CNR1
14 paranoid schizophrenia 29.1 COMT CNR1
15 tobacco addiction 29.0 OPRM1 COMT CNR1
16 morphine dependence 29.0 PTGS2 OPRM1
17 cannabis abuse 28.8 OPRM1 COMT CNR1
18 neonatal abstinence syndrome 28.8 OPRM1 COMT
19 somatoform disorder 28.8 OPRM1 COMT
20 heroin dependence 28.6 OPRM1 COMT
21 eating disorder 28.5 VGF OPRM1 COMT CNR1
22 obsolete: chronic pain requiring intraspinal analgesia 12.3
23 fibromyalgia 11.7
24 complex regional pain syndrome 11.5
25 hidradenitis suppurativa 11.5
26 trigeminal neuralgia 11.5
27 ehlers-danlos syndrome 11.4
28 interstitial cystitis 11.4
29 occipital neuralgia 11.4
30 headache 11.3
31 sickle cell disease 11.3
32 reflex sympathetic dystrophy 11.3
33 myofascial pain syndrome 11.3
34 causalgia 11.3
35 rheumatoid arthritis 11.2
36 osteoporosis 11.2
37 cauda equina syndrome 11.2
38 frozen shoulder 11.2
39 exostosis 11.2
40 melorheostosis 11.1
41 amyotrophy, hereditary neuralgic 11.0
42 corticosteroid-binding globulin deficiency 11.0
43 adiposis dolorosa 10.9
44 brachyolmia type 3 10.9
45 buschke-ollendorff syndrome 10.9
46 polycystic kidney disease 1 with or without polycystic liver disease 10.9
47 stiff-person syndrome 10.9
48 intervertebral disc disease 10.9
49 hypophosphatasia 10.9
50 neurilemmomatosis 10.9

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain

Symptoms & Phenotypes for Chronic Pain

MGI Mouse Phenotypes related to Chronic Pain:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 BDKRB1 CACNA1B CNR1 COMT DLG2 OPRM1
2 integument MP:0010771 9.5 BDKRB1 CACNA1B CNR1 DLG2 OPRM1 PTGS2
3 nervous system MP:0003631 9.23 CACNA1B CNR1 COMT DLG2 OPRM1 PTGS2

Drugs & Therapeutics for Chronic Pain

Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 573)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 401 6234
2
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
6
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
7
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
10
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
11 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
12
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
13
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
14
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
15
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
16
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
17
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
18
Norepinephrine Approved Phase 4 51-41-2 439260
19
Perphenazine Approved Phase 4 58-39-9 4748
20
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
21
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
22
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
23
Esketamine Approved, Investigational Phase 4 33643-46-8
24
Polidocanol Approved Phase 4 9002-92-0
25
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
26
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
27
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
28
Dihydrocodeine Approved, Illicit Phase 4 125-28-0
29
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
30
Propranolol Approved, Investigational Phase 4 525-66-6 4946
31
Aceclofenac Approved, Investigational Phase 4 89796-99-6
32
Rifampicin Approved Phase 4 13292-46-1 5458213 5381226
33
Pantoprazole Approved Phase 4 102625-70-7 4679
34
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
35
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
36
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
37
Desipramine Approved, Investigational Phase 4 50-47-5 2995
38
Phenol Approved, Experimental Phase 4 108-95-2 996
39
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
40
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
41
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
42
Meperidine Approved Phase 4 57-42-1 4058
43
Prazosin Approved Phase 4 19216-56-9 4893
44
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
45
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
46
Nicotine Approved Phase 4 54-11-5 942 89594
47
Remifentanil Approved Phase 4 132875-61-7 60815
48
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
49
Ibuprofen Approved Phase 4 15687-27-1 3672
50
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206

Interventional clinical trials:

(show top 50) (show all 3481)
# Name Status NCT ID Phase Drugs
1 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
2 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
3 The Effect of Angiotensin II Receptor Antagonists on Acute and Chronic Postoperative Pain in Patients Treated for Hypertension. Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
4 Brain Mechanisms For Clinical Placebo in Chronic Pain: A Randomized Clinical Trial of Placebo, Active Treatment, and No Treatment in Chronic Back Pain Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
5 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
6 Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design Unknown status NCT00484731 Phase 4
7 Investigator Initiated Trial- Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty. Comparison of Spinal Cord Stimulation and Comprehensive Medical Management Unknown status NCT01616342 Phase 4
8 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
11 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
12 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
13 a Randomized Controlled Trial of Dexmedetomidine on Chronic Postoperative Pain After Breast and Thoracic Surgery Unknown status NCT03275207 Phase 4 saline;dexmedetomidine
14 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
15 Abdominal Midline Incisional Hernia Repair and Functional Outcome: Randomized Controlled Trial to Compare Open and Laparoscopic Surgical Unknown status NCT00625053 Phase 4
16 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
17 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold: A Randomized, Double Blinded, Crossover Volunteer Study Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
18 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
19 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
20 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
21 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain: A Double-Blind, Randomized, Placebo-Controlled Study Unknown status NCT01920971 Phase 4
22 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
23 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
24 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
25 Intra-articular Botulinum Toxin Type A Versus Corticosteroids: a Clinical Trial in Osteoarthritis of Knees Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
26 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
27 Efficacy of Regional Analgesia Techniques (Quadratus Lumborum Block and Transversus Abdominis Plane Block) in Acute and Chronic Pain Treatment in Patients After Cesarean Delivery Unknown status NCT03244540 Phase 4 Ropivacaine;Paracetamol;Metamizol;Ketoprofen;Bupivacaine
28 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
29 Eight Week Feasibility Study Enrolling Dry Eye Subjects Confirmed by Four of Seven Dianostic Markers Responding to Nutritional Therapy Unknown status NCT01561040 Phase 4
30 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
31 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
32 Analgesic Effects of Local Anesthetic Serratus Plane Infiltration for Total Mastectomy Surgery: A Pilot Study Unknown status NCT02893384 Phase 4 Local Anesthetic Injection above the serratus anterior
33 The Impact of Botulinum Toxin Injection in the Frontalis on Brow Height and Morphology: A Randomized Trial Unknown status NCT03186001 Phase 4 Abobotulinum toxin A
34 Efficiency of Thoracolumbar Interfascial Plane Block in Lumbar Disk Surgery Unknown status NCT03180099 Phase 4 Bupivacaine;Bupivacaine
35 Comparison of Self Gripping Semi-resorbable Mesh (PROGRIP) With Polypropylene Mesh in Open Inguinal Hernia Repair - a Randomized Study Unknown status NCT00960011 Phase 4
36 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
37 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
38 Effectiveness of the Precision Spinal Cord Stimulation System in Patients With Failed Back Surgery Syndrome and Axial Low Back Pain Completed NCT00205868 Phase 4
39 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
40 Evaluation in Efficacy and Safety of Fentanyl-TTS (Durogesic® D-Trans) for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
41 Effects of Thoracic Paravertebral Blockade on Acute and Chronic Pain After Video Assisted Thoracoscopic Surgery (VATS) - A Randomized, Clinical Trial Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
42 The Effect of Pulse Width on the Treatment of Chronic Low Back Pain With Spinal Cord Stimulation Completed NCT00399516 Phase 4
43 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
44 Observational Registry: The Effectiveness of Pain Management Using the ARCHIMEDES® Implantable Constant-Flow Infusion Pump System for Intrathecal Delivery Completed NCT00196053 Phase 4
45 A CTSC Clinical Research Center Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
46 A Randomised Clinical Trial Evaluating the Effect of Remifentanil vs Fentanyl During Cardiac Surgery on the Incidence of Chronic Thoracic Pain Completed NCT02031016 Phase 4 Fentanyl;Remifentanil;Fentanyl
47 Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Chronic Low Back Pain or Chronic Lumbo-radiculalgia and Followed in Pain Treatment Centers Completed NCT00452010 Phase 4
48 N-of-1 Randomised Trials to Assess the Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Completed NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
49 Benefit of Laparoscopic Adhesiolysis Completed NCT02839564 Phase 4
50 Evaluation Study of Efficacy and Safety of TTS-Fentanyl in Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine

Search NIH Clinical Center for Chronic Pain

Genetic Tests for Chronic Pain

Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 29

Anatomical Context for Chronic Pain

MalaCards organs/tissues related to Chronic Pain:

40
Spinal Cord, Brain, Breast, Testes, Cortex, Bone, Prostate

Publications for Chronic Pain

Articles related to Chronic Pain:

(show top 50) (show all 30486)
# Title Authors PMID Year
1
Individual opioids, and long- versus short-acting opioids, for chronic noncancer pain: Protocol for a network meta-analysis of randomized controlled trials. 42
31651885 2019
2
Are there effective interventions for reducing the use of prescribed opioids in adults with chronic non-cancer pain? - A Cochrane Review summary with commentary. 42
31580469 2019
3
Identifying pain susceptibility phenotypes in knee osteoarthritis. 42
31621573 2019
4
Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation. 61
31960821 2020
5
High tibial osteotomy in a lax knee: A review of current concepts. 61
32021040 2020
6
Factors associated with chronic pain and non-medical opioid use among people who inject drugs. 61
31704433 2020
7
Determinants of quality of life among family caregivers of adult cancer patients in a resource-limited setting. 61
31240464 2020
8
Overactivity in Chronic Pain, the Role of Pain-related Endurance and Neuromuscular Activity: An Interdisciplinary, Narrative Review. 61
31833914 2020
9
Embodied Pain: There is a Need to Reflect Interactions Between Cognitions, Behavior, and Neuromuscular Activity in Chronic Pain. 61
31850934 2020
10
The Impact of Spatial Distribution of Pain on Long-Term Trajectories for Chronic Pain Outcomes After Intensive Interdisciplinary Pain Treatment. 61
31876790 2020
11
Prescribed and non-prescribed gabapentin use among persons seeking inpatient opioid detoxification. 61
31952626 2020
12
μ-Opioid and dopamine-D2 receptor expression in the nucleus accumbens of male Sprague-Dawley rats whose sucrose consumption, but not preference, decreases after nerve injury. 61
31836522 2020
13
Association Between Excessive Weight Gain During Pregnancy and Persistent Low Back and Pelvic Pain After Delivery. 61
31593058 2020
14
c-Jun N terminal kinase signaling pathways mediate cannabinoid tolerance in an agonist-specific manner. 61
31758947 2020
15
Psychological Subgrouping to Assess the Risk for the Development or Maintenance of Chronic Musculoskeletal Pain: Is This the Way Forward? 61
31833912 2020
16
Antinociceptive and genotoxic assessments of the antagonist TRPV1 receptor SB-366791 on morphine-induced tolerance in mice. 61
31655852 2020
17
Endogenous Modulation of Pain: The Role of Exercise, Stress, and Cognitions in Humans. 61
31833911 2020
18
The demographics of persistent opioid consumption following limb amputation. 61
31650532 2020
19
Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect. 61
30945801 2020
20
Lavandula angustifolia essential oil inhalation reduces mechanical hyperalgesia in a model of inflammatory and neuropathic pain: The involvement of opioid and cannabinoid receptors. 61
31945593 2020
21
Factors Related to Agreement Between Child and Caregiver Report of Child Functioning With Chronic Pain: PROMIS Pediatric and Parent Proxy Report. 61
31876791 2020
22
Chronic pain after breast surgery - still many unanswered questions: a reply. 61
32022920 2020
23
Interventional pain management for chronic pain: a survey of physicians in Canada. 61
31802414 2020
24
Management of chronic pain in newborn infants. 61
31489620 2020
25
Clarification on chronic pain - a painfully persistent problem? A reply. 61
32022918 2020
26
Chronic pain after breast surgery - still many unanswered questions. 61
32022919 2020
27
Clarification on chronic pain - a painfully persistent problem? 61
32022921 2020
28
Sex differences in the relationship between anxiety sensitivity and opioid misuse among adults with chronic pain. 61
31704430 2020
29
Effects of Tonic Spinal Cord Stimulation on External Mechanical and Thermal Stimuli Perception Using Quantitative Sensory Testing: A Multicenter Stimulation ON-OFF Study on Chronic Pain Patients. 61
31833916 2020
30
Developing a better biopsychosocial understanding of pain in inflammatory bowel disease: a cross-sectional study. 61
31851083 2020
31
Corrigendum to "Alexithymia moderates effects of psychotherapeutic treatment expectations on depression outcome in interdisciplinary chronic pain treatment" [Journal of Psychosomatic Research 122 (2019) 69-72]. 61
31972480 2020
32
NPPB prevents postoperative peritoneal adhesion formation by blocking volume-activated Cl- current. 61
31659404 2020
33
Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease. 61
31585747 2020
34
Assessing peripheral fibers, pain sensitivity, central sensitization, and descending inhibition in Native Americans: main findings from the Oklahoma Study of Native American Pain Risk. 61
31977838 2020
35
Transvaginal treatment of anterior and apical genital prolapse using Restorelle® direct fix™: An observational study of medium-term complications and outcomes. 61
31852622 2020
36
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. 61
31901745 2020
37
Anti-inflammatory coating of hernia repair meshes: a 5-rabbit study. 61
32026188 2020
38
Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems. 61
32026358 2020
39
High cortical delta power correlates with aggravated allodynia by activating anterior cingulate cortex GABAergic neurons in neuropathic pain mice. 61
31651580 2020
40
Screening of undiagnosed depression among elderly primary care patients: a cross-sectional study from the Republic of Srpska, Bosnia and Herzegovina. 61
31994858 2020
41
Secondary Analysis of Pain Outcomes in a Large Pragmatic Randomized Trial of Buprenorphine/Naloxone Versus Methadone for Opioid Use Disorder. 61
32039934 2020
42
Pulsed Radiofrequency Neuromodulation Contributes to Activation of Platelet-Rich Plasma in In Vitro Conditions. 61
32027438 2020
43
Elucidating somatization in a dimensional model of psychopathology across medical settings. 61
31599632 2020
44
Classism and dehumanization in chronic pain: A qualitative study of nurses' inferences about women of different socio-economic status. 61
31811704 2020
45
Application of ICD-11 among individuals with chronic pain: A post hoc analysis of the Stanford Self-Management Program. 61
31556212 2020
46
Acceptability and Effects of Commercially Available Activity Trackers for Chronic Pain Management Among Older African American Adults. 61
31509196 2020
47
A Novel G Protein-Biased Agonist at the δ Opioid Receptor with Analgesic Efficacy in Models of Chronic Pain. 61
31594792 2020
48
Biopsychosocial factors associated with poor health-related quality of life after minor to moderate transport-related injuries: Insights into the Victorian compensable population. 61
31616954 2020
49
A Cross-Sectional Examination of Patients' Perspectives About Their Pain, Pain Management, and Satisfaction with Pain Treatment. 61
31609389 2020
50
Pain Management Telementoring, Long-term Opioid Prescribing, and Patient-Reported Outcomes. 61
31876948 2020

Variations for Chronic Pain

ClinVar genetic disease variations for Chronic Pain:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CPT2 NM_000098.3(CPT2):c.149C>A (p.Pro50His)SNV Pathogenic 8954 rs28936375 1:53662764-53662764 1:53197092-53197092
2 USH2A NM_007123.5(USH2A):c.2299del (p.Glu767fs)deletion Pathogenic/Likely pathogenic 2351 rs80338903 1:216420437-216420437 1:216247095-216247095
3 USH2A NM_206933.3(USH2A):c.5003G>T (p.Gly1668Val)SNV Uncertain significance 598989 rs1265349835 1:216258204-216258204 1:216084862-216084862
4 MYH8 NM_002472.3(MYH8):c.5743A>G (p.Ile1915Val)SNV Uncertain significance 598988 rs1216879928 17:10293842-10293842 17:10390525-10390525

Expression for Chronic Pain

Search GEO for disease gene expression data for Chronic Pain.

Pathways for Chronic Pain

Pathways related to Chronic Pain according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 PTGS2 OPRM1 CNR1 CACNA1B
2 11.56 PTGS2 OPRM1 DLG2 COMT CNR1
3 10.6 PTGS2 CNR1

GO Terms for Chronic Pain

Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.92 OPRM1 DLG2 COMT CNR1

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cocaine GO:0042220 9.48 OPRM1 CNR1
2 response to radiation GO:0009314 9.46 PTGS2 OPRM1
3 regulation of sensory perception of pain GO:0051930 9.43 OPRM1 COMT
4 regulation of NMDA receptor activity GO:2000310 9.4 OPRM1 DLG2
5 response to morphine GO:0043278 9.37 OPRM1 CNR1
6 response to lipopolysaccharide GO:0032496 9.35 PTGS2 OPRM1 COMT CNR1 BDKRB1
7 negative regulation of blood pressure GO:0045776 9.32 CNR1 BDKRB1
8 response to pain GO:0048265 9.26 COMT CACNA1B
9 positive regulation of fever generation GO:0031622 9.16 PTGS2 CNR1
10 sensory perception of pain GO:0019233 9.02 PTGS2 OPRM1 DLG2 CNR1 BDKRB1

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel activity GO:0005245 8.62 OPRM1 CACNA1B

Sources for Chronic Pain

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....