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MCID: CHR345
MIFTS: 44

Chronic Pain

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Drugs
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Aliases & Classifications for Chronic Pain

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MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 53 29 6 42
Pain - Chronic 53

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Chronic Pain

About this section
NINDS : 53 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to dysautonomia and fibromyalgia. An important gene associated with Chronic Pain is USH2A (Usherin). The drugs Cycloserine and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and breast.

MedlinePlus : 42 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

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Related Diseases for Chronic Pain

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Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 585)
# Related Disease Score Top Affiliating Genes
1 dysautonomia 29.2 USH2A CPT2
2 fibromyalgia 11.7
3 complex regional pain syndrome 11.5
4 paine syndrome 11.5
5 hidradenitis suppurativa 11.5
6 trigeminal neuralgia 11.4
7 ehlers-danlos syndrome 11.4
8 interstitial cystitis 11.4
9 occipital neuralgia 11.4
10 headache 11.3
11 sickle cell disease 11.3
12 opioid addiction 11.3
13 reflex sympathetic dystrophy 11.3
14 myofascial pain syndrome 11.3
15 causalgia 11.3
16 rheumatoid arthritis 11.2
17 osteoporosis 11.2
18 stiff-person syndrome 11.2
19 cauda equina syndrome 11.2
20 exostosis 11.2
21 medullary sponge kidney 11.2
22 melorheostosis 11.1
23 amyotrophy, hereditary neuralgic 11.0
24 corticosteroid-binding globulin deficiency 11.0
25 adiposis dolorosa 10.9
26 brachyolmia type 3 10.9
27 buschke-ollendorff syndrome 10.9
28 polycystic kidney disease 1 with or without polycystic liver disease 10.9
29 intervertebral disc disease 10.9
30 hypophosphatasia 10.9
31 neurilemmomatosis 10.9
32 herpes zoster ophthalmicus 10.9
33 pudendal neuralgia 10.9
34 anterior cutaneous nerve entrapment syndrome 10.9
35 back pain 10.8
36 malonyl-coa decarboxylase deficiency 10.8
37 dientamoebiasis 10.8
38 depression 10.6
39 pain agnosia 10.6
40 spinal cord injury 10.6
41 inguinal hernia 10.6
42 anxiety 10.6
43 substance abuse 10.6
44 constipation 10.5
45 migraine with or without aura 1 10.5
46 osteoarthritis 10.5
47 diabetic neuropathy 10.5
48 neuropathy 10.5
49 opiate dependence 10.5
50 opioid abuse 10.4

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain
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Symptoms & Phenotypes for Chronic Pain

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Drugs & Therapeutics for Chronic Pain

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Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 573)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 401 6234
2
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
6
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
7
Fluoxymesterone Approved, Illicit Phase 4 76-43-7 6446
8
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
9
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
10
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
11
Capsaicin Approved Phase 4 404-86-4 1548943
12
Esketamine Approved, Investigational Phase 4 33643-46-8
13
Nalbuphine Approved Phase 4 20594-83-6 5311304 5360630
14
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
15
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
16
Polidocanol Approved Phase 4 9002-92-0
17
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
18
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
19
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
20
Propranolol Approved, Investigational Phase 4 525-66-6 4946
21
Aceclofenac Approved, Investigational Phase 4 89796-99-6
22
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
23
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
24
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
25
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
26
Ferrous fumarate Approved Phase 4 141-01-5
27
Norethindrone Approved Phase 4 68-22-4 6230
28
Desipramine Approved, Investigational Phase 4 50-47-5 2995
29
Phenol Approved, Experimental Phase 4 108-95-2 996
30
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
31
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
32
Prazosin Approved Phase 4 19216-56-9 4893
33
Oxytocin Approved, Vet_approved Phase 4 50-56-6 53477758 439302
34
Nicotine Approved Phase 4 54-11-5 942 89594
35
Remifentanil Approved Phase 4 132875-61-7 60815
36
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
37
Ibuprofen Approved Phase 4 15687-27-1 3672
38
Palonosetron Approved, Investigational Phase 4 135729-56-5, 119904-90-4 148211
39
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
40
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
41
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
42
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
43
Tibolone Approved, Investigational Phase 4 5630-53-5
44
Calcium carbonate Approved, Investigational Phase 4 471-34-1
45
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
46
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
47
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
48
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
49
Ethanol Approved Phase 4 64-17-5 702
50
Midazolam Approved, Illicit Phase 4 59467-70-8 4192

Interventional clinical trials:

(show top 50) (show all 3762)
# Name Status NCT ID Phase Drugs
1 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
2 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
3 Efficacy and Safety of Dexamethasone Versus Betamethasone Epidural Caudal Administration for Treatment of Lumbosacral Radiculalgia: Randomized Clinical Trial Unknown status NCT02833116 Phase 4 Betamethasone;Dexamethasone
4 The Effect of Angiotensin II Receptor Antagonists on Acute and Chronic Postoperative Pain in Patients Treated for Hypertension. Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
5 Brain Mechanisms For Clinical Placebo in Chronic Pain: A Randomized Clinical Trial of Placebo, Active Treatment, and No Treatment in Chronic Back Pain Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
6 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
7 Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design Unknown status NCT00484731 Phase 4
8 Investigator Initiated Trial- Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty. Comparison of Spinal Cord Stimulation and Comprehensive Medical Management Unknown status NCT01616342 Phase 4
9 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
10 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
11 Safety and Efficacy of Medical Cannabis Oil in the Treatment of Patients With Chronic Pain: A Randomized, Double-Blind, Placebo-Controlled Pilot Study, Followed by an Open-Label Extension Phase Unknown status NCT03337503 Phase 4 THC and CDB in a 1 to 1 ratio;Experimental: THC and CBD in a 1 to 2 ratio;High CBD with trace THC oil
12 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
13 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
14 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
15 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
16 a Randomized Controlled Trial of Dexmedetomidine on Chronic Postoperative Pain After Breast and Thoracic Surgery Unknown status NCT03275207 Phase 4 saline;dexmedetomidine
17 Abdominal Midline Incisional Hernia Repair and Functional Outcome: Randomized Controlled Trial to Compare Open and Laparoscopic Surgical Unknown status NCT00625053 Phase 4
18 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold: A Randomized, Double Blinded, Crossover Volunteer Study Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
19 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
20 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain Unknown status NCT02527083 Phase 4 Propofol;Sevoflurane;Remifentanil;Ketamine
21 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
22 Evaluation of Triamcinolone`s Efficacy on the Ultrasound- Guided Infiltration in the Quadratus Lumborum Syndrome: a Double Blind, Randomized, Controlled Study Unknown status NCT03407027 Phase 4 Quadratus triamcinolone;Gluteus triamcinolone;quadratus without triamcinolone.
23 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
24 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
25 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain: A Double-Blind, Randomized, Placebo-Controlled Study Unknown status NCT01920971 Phase 4
26 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
27 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
28 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
29 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
30 Intra-articular Botulinum Toxin Type A Versus Corticosteroids: a Clinical Trial in Osteoarthritis of Knees Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
31 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
32 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
33 Eight Week Feasibility Study Enrolling Dry Eye Subjects Confirmed by Four of Seven Dianostic Markers Responding to Nutritional Therapy Unknown status NCT01561040 Phase 4
34 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
35 The Impact of Botulinum Toxin Injection in the Frontalis on Brow Height and Morphology: A Randomized Trial Unknown status NCT03186001 Phase 4 Abobotulinum toxin A
36 Analgesic Effects of Local Anesthetic Serratus Plane Infiltration for Total Mastectomy Surgery: A Pilot Study Unknown status NCT02893384 Phase 4 Local Anesthetic Injection above the serratus anterior
37 Efficiency of Thoracolumbar Interfascial Plane Block in Lumbar Disk Surgery Unknown status NCT03180099 Phase 4 Bupivacaine;Bupivacaine
38 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
39 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
40 Effectiveness of the Precision Spinal Cord Stimulation System in Patients With Failed Back Surgery Syndrome and Axial Low Back Pain Completed NCT00205868 Phase 4
41 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
42 Evaluation in Efficacy and Safety of Fentanyl-TTS (Durogesic® D-Trans) for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
43 Effects of Thoracic Paravertebral Blockade on Acute and Chronic Pain After Video Assisted Thoracoscopic Surgery (VATS) - A Randomized, Clinical Trial Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
44 The Effect of Pulse Width on the Treatment of Chronic Low Back Pain With Spinal Cord Stimulation Completed NCT00399516 Phase 4
45 Interscalene Block Versus Superior Trunk Block: A Randomized Controlled Clinical Trial Completed NCT03272139 Phase 4 Bupivacaine
46 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
47 Observational Registry: The Effectiveness of Pain Management Using the ARCHIMEDES® Implantable Constant-Flow Infusion Pump System for Intrathecal Delivery Completed NCT00196053 Phase 4
48 A CTSC Clinical Research Center Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
49 A Randomised Clinical Trial Evaluating the Effect of Remifentanil vs Fentanyl During Cardiac Surgery on the Incidence of Chronic Thoracic Pain Completed NCT02031016 Phase 4 Fentanyl;Remifentanil;Fentanyl
50 Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Chronic Low Back Pain or Chronic Lumbo-radiculalgia and Followed in Pain Treatment Centers Completed NCT00452010 Phase 4

Search NIH Clinical Center for Chronic Pain

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Genetic Tests for Chronic Pain

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Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 29
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Anatomical Context for Chronic Pain

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MalaCards organs/tissues related to Chronic Pain:

40
Spinal Cord, Brain, Breast, Testes, Cortex, Bone, Prostate
Sources

Publications for Chronic Pain

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Articles related to Chronic Pain:

(show top 50) (show all 30503)
# Title Authors PMID Year
1
Personalized electro-acupuncture versus auricular-acupuncture comparative effectiveness (PEACE): A protocol of a randomized controlled trial for chronic musculoskeletal pain in cancer survivors. 42 61
32481275 2020
2
Pain acceptance levels of patients with chronic pain. 61 42
32332641 2020
3
Consequences of Chronic Non-Cancer Pain in adulthood. Scoping Review. 42 61
32321056 2020
4
Vortioxetine reduces pain hypersensitivity and associated depression-like behavior in mice with oxaliplatin-induced neuropathy. 61
32464241 2020
5
A survey of chronic pain in China. 61
32066339 2020
6
The therapeutic efficacy of Qigong exercise on the main symptoms of fibromyalgia: A pilot randomized clinical trial. 61
32455108 2020
7
Repeated exposure of naïve and peripheral nerve-injured mice to a snake as an experimental model of post-traumatic stress disorder and its co-morbidity with neuropathic pain. 61
32474017 2020
8
Neuronal interleukin-1 receptors mediate pain in chronic inflammatory diseases. 61
32573694 2020
9
Neuropeptide and cytokine regulation of pain in the context of substance use disorders. 61
32470337 2020
10
Female Genital Mutilation/Cutting as Grounds for Asylum Requests in the US: An Analysis of More than 100 Cases. 61
32189161 2020
11
Interindividual variability and lateralization of μ-opioid receptors in the human brain. 61
32407992 2020
12
Continuous infusion of substance P into rat striatum relieves mechanical hypersensitivity caused by a partial sciatic nerve ligation via activation of striatal muscarinic receptors. 61
32461131 2020
13
Chemokines in chronic pain: cellular and molecular mechanisms and therapeutic potential. 61
32450191 2020
14
Fear in the context of pain: Lessons learned from 100 years of fear conditioning research. 61
32417719 2020
15
Extended overview of the longitudinal pain-depression association: A comparison of six cohorts treated for specific chronic pain conditions. 61
32560947 2020
16
The Pelvic Girdle Pain deadlock: 2. Topics that, so far, have remained out of focus. 61
32560869 2020
17
Behavioral and neurophysiological evidence for altered interoceptive bodily processing in chronic pain. 61
32438047 2020
18
Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain. 61
32344063 2020
19
Exposure to greenspaces could reduce the high global burden of pain. 61
32447087 2020
20
Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation. 61
32350708 2020
21
The transversus abdominis plane block may reduce chronic postoperative pain one year after TAPP ingunial hernia repair. 61
32518639 2020
22
Feline Chronic Pain and Osteoarthritis. 61
32354489 2020
23
Chronic pain, cardiovascular health and related medication use in ageing African Americans with osteoarthritis. 61
32301200 2020
24
Neurogeriatrics-a vision for improved care and research for geriatric patients with predominating neurological disabilities. 61
32430766 2020
25
Parent cognitive, behavioural, and affective factors and their relation to child pain and functioning in pediatric chronic pain: a systematic review and meta-analysis. 61
32132395 2020
26
Investigation of cannabidiol gastro retentive tablets based on regional absorption of cannabinoids in rats. 61
32422168 2020
27
The projections from the anterior cingulate cortex to the nucleus accumbens and ventral tegmental area contribute to neuropathic pain-evoked aversion in rats. 61
32251841 2020
28
Parental perspectives on early childhood caries: A qualitative study. 61
32011057 2020
29
Pain thresholds and intensities of CRPS type I and neuropathic pain in respect to sex. 61
32096888 2020
30
Qualitative sex differences in pain processing: emerging evidence of a biased literature. 61
32440016 2020
31
Necessary components of psychological treatment in pain management programs: A Delphi study. 61
32187442 2020
32
Perceptions of Pain Treatment in Pediatric Patients With Functional Gastrointestinal Disorders. 61
32310832 2020
33
Revision of a dual-modular stem in patients with adverse tissue reaction. 61
31390922 2020
34
Longitudinal Associations Between Pain and Psychosocial Adjustment in Youth With Spina Bifida. 61
32483627 2020
35
Optimizing the Treatment of CRPS With Ketamine. 61
32243301 2020
36
Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis? 61
31990749 2020
37
Novel insights into stroke pain beliefs and perceptions. 61
31821126 2020
38
Increased immediate early gene activation in the basolateral amygdala following persistent peripheral inflammation. 61
32501889 2020
39
Caring for patients with pain during the COVID-19 pandemic: consensus recommendations from an international expert panel. 61
32259288 2020
40
The Effect of Age and Pain on Quantitative Sensory Testing Measurements After Moderate-to-Severe Traumatic Brain Injury: Preliminary Findings. 61
32208852 2020
41
Ketamine for Chronic Pain: Old Drug New Trick? 61
32550679 2020
42
Imaging of chronic male pelvic pain: what the abdominal imager should know. 61
31834458 2020
43
A Novel, Reliable Protocol to Objectively Assess Scar Stiffness Using Shear Wave Elastography. 61
32386847 2020
44
Alterations in mouse spinal cord and sciatic nerve microRNAs after the chronic constriction injury (CCI) model of neuropathic pain. 61
32380144 2020
45
Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation. 61
31960821 2020
46
Common transcriptional signatures of neuropathic pain. 61
32107361 2020
47
The International Classification of Diseases, 11th Revision: A Step-Back for Women With Vulvodynia? 61
32068619 2020
48
Ablation of spinal cord estrogen receptor α-expressing interneurons reduces chemically induced modalities of pain and itch. 61
31872868 2020
49
Daring discourse - no: cannabinoids should not be used for acute postoperative pain management. 61
32471920 2020
50
Environment and Feline Health: At Home and in the Clinic. 61
32482333 2020
Sources

Variations for Chronic Pain

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ClinVar genetic disease variations for Chronic Pain:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CPT2 NM_000098.3(CPT2):c.149C>A (p.Pro50His)SNV Pathogenic 8954 rs28936375 1:53662764-53662764 1:53197092-53197092
2 USH2A NM_007123.5(USH2A):c.2299del (p.Glu767fs)deletion Pathogenic/Likely pathogenic 2351 rs80338903 1:216420437-216420437 1:216247095-216247095
3 USH2A NM_206933.3(USH2A):c.5003G>T (p.Gly1668Val)SNV Uncertain significance 598989 rs1265349835 1:216258204-216258204 1:216084862-216084862
4 MYH8 NM_002472.3(MYH8):c.5743A>G (p.Ile1915Val)SNV Uncertain significance 598988 rs1216879928 17:10293842-10293842 17:10390525-10390525
Sources

Expression for Chronic Pain

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Search GEO for disease gene expression data for Chronic Pain.
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Pathways for Chronic Pain

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GO Terms for Chronic Pain

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Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood pressure GO:0045776 8.96 CNR1 BDKRB1
2 sensory perception of pain GO:0019233 8.8 DLG2 CNR1 BDKRB1
Sources

Sources for Chronic Pain

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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