Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CHR345
MIFTS: 51

Chronic Pain

Categories: Rare diseases, Mental diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Chronic Pain

About this section

MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 54 29 43
Pain - Chronic 54

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Chronic Pain

About this section
NINDS : 54 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to opioid addiction and drug dependence. An important gene associated with Chronic Pain is CNR1 (Cannabinoid Receptor 1), and among its related pathways/superpathways are GABAergic synapse and Calcium signaling pathway. The drugs Naproxen and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, breast and brain, and related phenotypes are behavior/neurological and homeostasis/metabolism

MedlinePlus : 43 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. They include Pain Relievers and other medicines Acupuncture Electrical stimulation Surgery Physical therapy Psychotherapy Relaxation and meditation therapy Biofeedback NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Sources

Related Diseases for Chronic Pain

About this section

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 opioid addiction 31.0 COMT OPRM1
2 drug dependence 29.4 CNR1 OPRM1
3 post-traumatic stress disorder 29.1 CNR1 COMT
4 somatoform disorder 29.0 COMT OPRM1
5 eating disorder 28.9 CNR1 COMT
6 substance dependence 28.7 CNR1 OPRM1
7 alcohol dependence 28.2 CNR1 COMT OPRM1
8 chronic pain requiring intraspinal analgesia 12.0
9 paine syndrome 11.2
10 trigeminal neuralgia 11.1
11 complex regional pain syndrome 11.1
12 fibromyalgia 11.1
13 interstitial cystitis 11.1
14 ehlers-danlos syndrome 10.9
15 reflex sympathetic dystrophy 10.9
16 sickle cell disease 10.9
17 myofascial pain syndrome 10.9
18 arthritis 10.9
19 causalgia 10.9
20 headache 10.9
21 corticosteroid-binding globulin deficiency 10.7
22 occipital neuralgia 10.7
23 melorheostosis 10.7
24 adiposis dolorosa 10.6
25 polycystic kidney disease 1 with or without polycystic liver disease 10.6
26 frozen shoulder 10.6
27 anterior cutaneous nerve entrapment syndrome 10.6
28 cauda equina syndrome 10.6
29 pudendal neuralgia 10.6
30 brachyolmia type 3 10.6
31 stiff-person syndrome 10.6
32 amyotrophy, hereditary neuralgic 10.6
33 exostosis 10.6
34 cyclic vomiting syndrome 10.2 CNR1 OPRM1
35 depression 10.2
36 withdrawal disorder 10.1 CNR1 OPRM1
37 morphine dependence 10.1 OPRM1 PTGS2
38 polysubstance abuse 10.1 CNR1 COMT
39 cannabis dependence 10.1 CNR1 COMT
40 anxiety 10.0
41 spinal cord injury 10.0
42 inguinal hernia 10.0
43 whiplash 10.0
44 opioid abuse 10.0
45 neonatal abstinence syndrome 9.9 COMT OPRM1
46 neuropathy 9.9
47 aging 9.9
48 pain agnosia 9.8 CNR1 OPRM1 PTGS2
49 agnosia 9.8 CNR1 OPRM1 PTGS2
50 osteoarthritis 9.8

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain
Sources

Symptoms & Phenotypes for Chronic Pain

About this section

MGI Mouse Phenotypes related to Chronic Pain:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CACNA1B CNR1 COMT DLG2 OPRM1 P2RX7
2 homeostasis/metabolism MP:0005376 9.7 CACNA1B CNR1 COMT OPRM1 P2RX4 P2RX7
3 integument MP:0010771 9.43 CACNA1B CNR1 DLG2 OPRM1 P2RX7 PTGS2
4 nervous system MP:0003631 9.17 CACNA1B CNR1 COMT DLG2 OPRM1 P2RX4
Sources

Drugs & Therapeutics for Chronic Pain

About this section

Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 501)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22204-53-1 1302 156391
2
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
3
Menthol Approved Phase 4,Phase 1,Phase 2,Not Applicable 2216-51-5 16666
4
Nicotine Approved Phase 4,Phase 2,Not Applicable 54-11-5 942 89594
5
Remifentanil Approved Phase 4,Phase 3,Phase 2,Not Applicable 132875-61-7 60815
6
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
7
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2180-92-9, 38396-39-3 2474
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
9
Acetylcholine Approved Phase 4,Phase 2,Early Phase 1 51-84-3 187
10
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52485-79-7 40400 644073
11
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27203-92-5 33741
12
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
13
Tibolone Approved, Investigational Phase 4 5630-53-5
14 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 979-32-8
15
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Not Applicable 15307-86-5 3033
16
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
17
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6740-88-1 3821
18
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
19
Methadone Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 76-99-3 4095
20
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Not Applicable 50-48-6 2160
21
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 57-27-2 5288826
22
Capsaicin Approved Phase 4,Phase 2,Not Applicable 404-86-4 1548943
23
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
24
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
25
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 50-02-2 5743
26
Calcium Carbonate Approved, Investigational Phase 4 471-34-1
27
Flurbiprofen Approved, Investigational Phase 4,Not Applicable 5104-49-4 3394
28
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
29
Naloxone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 465-65-6 5284596
30
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 76-42-6 5284603
31
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 50-24-8 5755
32
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
33
Dezocine Approved, Investigational Phase 4 53648-55-8 40841 3033053
34
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 84057-95-4 71273 175805
35
Palonosetron Approved, Investigational Phase 4 135729-61-2, 119904-90-4, 135729-56-5 148211
36
Citalopram Approved Phase 4,Not Applicable 59729-33-8 2771
37
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable 15687-27-1 3672
38
Levonorgestrel Approved, Investigational Phase 4,Not Applicable 797-63-7, 17489-40-6 13109
39
Sufentanil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56030-54-7 41693
40
Milnacipran Approved, Investigational Phase 4,Not Applicable 92623-85-3 65833
41
Perphenazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-39-9 4748
42
Amphetamine Approved, Illicit, Investigational Phase 4,Not Applicable 300-62-9 5826 3007
43
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Phase 1 5949-44-0
44
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 1,Not Applicable 466-99-9 5284570
45
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Not Applicable 378-44-9 9782
46
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
47
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 64-17-5 702
48
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 50-28-2 5757
49
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 1 58-22-0 6013
50
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181

Interventional clinical trials:

(show top 50) (show all 2147)
# Name Status NCT ID Phase Drugs
1 Intraoperative Ketamine on Chronic Pain After Mastectomy Unknown status NCT02729805 Phase 4 Saline;Ketamine 0.5mg/kg;Ketamine 0.75mg/kg
2 Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
3 Effect of Intraoperative Infiltration With Bupivacain on the Development of Chronic Pain After Inguinal Hernia Repair Unknown status NCT00484731 Phase 4
4 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
5 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4
6 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Efficacy of Pregabalin in the Management of Chronic Uremic Pruritus Unknown status NCT01073501 Phase 4 Pregabalin;Placebo
11 Psychological Impact of Amenorrhea in Women With Endometriosis Unknown status NCT02393482 Phase 4 Estroprogestinic therapy (Etinil-estradiol/levonorgestre);Gonadotropin-releasing hormone agonist (Leuprorelin acetate);Add back therapy 1 (tibolone);Add back therapy 2 (calcium carbonate/colecalciferol)
12 Comparison of Two Kinds of Postoperative Analgesia After Amputation Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
13 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
14 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
15 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
16 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
17 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
18 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
19 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
20 Oral Nutrition Impact on Tear Film Unknown status NCT01561040 Phase 4
21 Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
22 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
23 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
24 Prolotherapy for the Treatment of Plantar Fasciitis Unknown status NCT01326351 Phase 4
25 Postoperative Pain and Angiotensin II Receptor Antagonists Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
26 Acetaminophen for Chronic Pain in Hysterectomy Completed NCT02086747 Phase 4 Acetaminophen;Isotonic
27 Pharmacokinetic Study of Hydrocodone/APAP in Chronic Pain Patients Completed NCT01517295 Phase 4 Hydrocodone
28 Efficacy and Safety Study of Fentanyl Transdermal Patch for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
29 Chronic Pain After Inguinal Hernia Repair Completed NCT00820131 Phase 4
30 An Interventional Study to Compare the Efficacy and Tolerability With Targin® in Non-malignant Chronic Pain (GLORY) Completed NCT01811186 Phase 4 Oxycodone/naloxone
31 Dexamethasone and Pain Following Total Knee Arthroplasty Completed NCT02271698 Phase 4 Dexamethasone
32 Effects of Perioperative Intravenous Lidocaine and Ketamine on Acute and Chronic Pain After Open Nephrectomy Completed NCT02653651 Phase 4 Ketamine;Lidocaine;Placebo
33 Chronic Pain After Amputation Completed NCT00006427 Phase 4 Amitriptyline
34 Chronic Pain in Spinal Cord Injury Completed NCT00006428 Phase 4 Amitriptyline
35 Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS) Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
36 Evaluation of Risk Minimization, Assessment and Outcomes in Patients With Chronic Pain Taking Avinza Completed NCT00640042 Phase 4 morphine sulfate extended release capsules
37 Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Completed NCT00879996 Phase 4 Methadone;Buprenorphine/naloxone
38 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
39 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
40 A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
41 Imaging Pain Relief in Osteoarthritis Completed NCT02208778 Phase 4 Duloxetine;Remifentanil;Placebo (for Remifentanil);Placebo (for Duloxetine)
42 Effect of Extended-release Oxymorphone Taking With or Without Food on Cognitive Functioning Completed NCT00930943 Phase 4 Oxymorphone ER (Opana ER)
43 Efficacy Study of the Octapolar Lead in Patients With Failed Back Surgery Syndrome (FBSS) With Chronic Pain Completed NCT01096147 Phase 4
44 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
45 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Thai Participants With Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
46 Preperitoneal Versus Pre-trasversalis Hernia Repair Completed NCT01350830 Phase 4
47 Benefit of Laparoscopic Adhesiolysis in Patients With Chronische Abdominal Pain Completed NCT02839564 Phase 4
48 Does Intraoperative Methadone Prevent Postoperative Pain in Bariatric Surgery? Completed NCT02775474 Phase 4 Use of Intraoperative Intravenous Methadone;Use of Intraoperative Intravenous Fentanyl
49 Impact of Polymorphisms of OCT2 and OCTN1 on the Kinetic Disposition of Gabapentin in Patients Undergoing Chronic Use Completed NCT02977208 Phase 4 Gabapentin
50 Spinal Cord Stimulation for Low Back Pain Completed NCT00205868 Phase 4

Search NIH Clinical Center for Chronic Pain

Sources

Genetic Tests for Chronic Pain

About this section

Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 29
Sources

Anatomical Context for Chronic Pain

About this section

MalaCards organs/tissues related to Chronic Pain:

41
Spinal Cord, Breast, Brain, Testes, Cortex, Lung, Eye
Sources

Publications for Chronic Pain

About this section

Articles related to Chronic Pain:

(show top 50) (show all 954)
# Title Authors Year
1
Chronic pain and geriatric syndromes in community-dwelling patients aged a8Y65 years. ( 29950889 )
2018
2
Pregabalin versus placebo in targeting pro-nociceptive mechanisms to prevent chronic pain after whiplash injury in at-risk individuals - a feasibility study for a randomised controlled trial. ( 29343280 )
2018
3
Physical and psychosocial factors in the prevention of chronic pain in older age. ( 29949780 )
2018
4
Chronic pain in medullary sponge kidney: a rare and never described clinical presentation. ( 29468561 )
2018
5
Longitudinal resting-state fMRI in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
2018
6
Opiate Dependence or Addiction?: A Review of the Centers for Disease Control and Prevention Guidelines for Management of Chronic Pain. ( 29505462 )
2018
7
Transcranial Direct Current Stimulation as a Therapeutic Tool for Chronic Pain. ( 29952860 )
2018
8
Prioritizing pediatric chronic pain and comprehensive pain treatment in the context of the opioid epidemic. ( 29451426 )
2018
9
Transcutaneous electrical nerve stimulation and interferential current demonstrate similar effects in relieving acute and chronic pain: a systematic review with meta-analysis. ( 29426587 )
2018
10
Identification of FAM173B as a protein methyltransferase promoting chronic pain. ( 29444090 )
2018
11
Computerised training improves cognitive performance in chronic pain: a participant-blinded randomised active-controlled trial with remote supervision. ( 29447133 )
2018
12
Clinimetric properties of the Nepali version of the Pain Catastrophizing Scale in individuals with chronic pain. ( 29430196 )
2018
13
Effects of Higher Versus Lower Threat Contexts on Pain-Related Visual Attention Biases: an Eye-Tracking Study of Chronic Pain. ( 29452312 )
2018
14
Chronic pain, discomfort, quality of life and impact on sex life after open inguinal hernia mesh repair: an expertise-based randomized clinical trial comparing lightweight and heavyweight mesh. ( 29353339 )
2018
15
New Concepts of Chronic Pain and the Potential Role of Complementary Therapies. ( 29428928 )
2018
16
Youth with Chronic Pain and Postural Orthostatic Tachycardia Syndrome (POTS): Treatment Mediators of Improvement in Functional Disability. ( 29508112 )
2018
17
Expanding the role of clinical pharmacists on interdisciplinary primary care teams for chronic pain and opioid management. ( 29970008 )
2018
18
Ziconotide: Indications, Adverse Effects, and Limitations in Managing Refractory Chronic Pain. ( 29440821 )
2018
19
Anterior insular volume decrease is associated with dysfunction of the reward system in patients with chronic pain. ( 29436061 )
2018
20
Protocol for the Individual Placement and Support (IPS) in Pain Trial: A randomized controlled trial investigating the effectiveness of IPS for patients with chronic pain. ( 29433493 )
2018
21
Exacerbation of chronic pain after dental extractions in a patient with post-treatment Lyme disease syndrome. ( 29416466 )
2018
22
Potentiation of cortical excitatory transmission in chronic pain. ( 29944613 )
2018
23
Depressive Disorder, Anxiety Disorder and Chronic Pain: Multiple Manifestations of a Common Clinical and Pathophysiological Core. ( 29428122 )
2018
24
Seeking virtual social support through blogging: A content analysis of published blog posts written by people with chronic pain. ( 29942635 )
2018
25
A population-based examination of the co-occurrence and functional correlates of chronic pain and generalized anxiety disorder. ( 29703452 )
2018
26
Cognitive, emotional, and behavioral considerations for chronic pain management in the Ehlers-Danlos syndrome hypermobility-type: a narrative review. ( 29357706 )
2018
27
Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy. ( 29105244 )
2018
28
Case of chronic pain after laparoscopic percutaneous extraperitoneal closure in an adolescent girl with inguinal hernia in which open repair was effective. ( 29956498 )
2018
29
Perceived injustice in chronic pain: an examination through the lens of predictive processing. ( 29451429 )
2018
30
A retrospective study of transcutaneous electrical nerve stimulation for chronic pain following ankylosing spondylitis. ( 29979392 )
2018
31
The impact of a short educational movie on promoting chronic pain health literacy in school: a feasibility study. ( 29436071 )
2018
32
Level of readiness of chronic pain patients to practice active self-care. ( 29956872 )
2018
33
Avoiding Catch-22: validating the PainDETECT in a in a population of patients with chronic pain. ( 29958535 )
2018
34
Characterizing the demographics of chronic pain patients in the state of Maine using the Maine all payer claims database. ( 29954350 )
2018
35
Sleep Disturbances in Chronic Pain: Neurobiology, Assessment, and Treatment in Physical Therapist Practice. ( 29425327 )
2018
36
Attitudes of Irish patients with chronic pain towards medicinal cannabis. ( 29423824 )
2018
37
Preclinical assessment of utility of M6S for multimodal acute and chronic pain treatment in diabetic neuropathy. ( 29191644 )
2018
38
Chronic pain in narcolepsy type 1 and type 2 - an underestimated reality. ( 29923259 )
2018
39
Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis. ( 29955555 )
2018
40
Comment on "Pregabalin Effect on Acute and Chronic Pain after Cardiac Surgery". ( 29973953 )
2018
41
Barriers to the availability and accessibility of controlled medicines for chronic pain in Africa. ( 29447356 )
2018
42
Chronic pain and its association with obesity among older adults in China. ( 29427812 )
2018
43
Longitudinal Associations Between Provision of Autonomy Support and Well-Being in Spouses of Individuals With Chronic Pain. ( 29947732 )
2018
44
Cuff Pressure Algometry in Patients with Chronic Pain as Guidance for Circumferential Tissue Compression for Wearable Soft Exoskeletons: A Systematic Review. ( 29957130 )
2018
45
Integrating culturally informed approaches into physiotherapy assessment and treatment of chronic pain: a pilot randomised controlled trial. ( 29980547 )
2018
46
Serotonin-1A receptor dependent modulation of pain and reward for improving therapy of chronic pain. ( 29969666 )
2018
47
Cumulative effects of multiple pains sites in youth with chronic pain. ( 29436161 )
2018
48
The Association Between Cannabis Use and Aberrant Behaviors During Chronic Opioid Therapy for Chronic Pain. ( 29947796 )
2017
49
The triallelic serotonin transporter gene polymorphism is associated with depressive symptoms in adults with chronic pain. ( 28533695 )
2017
50
Chronic pain and opioid abuse: Factors associated with health-related quality of life. ( 29160596 )
2017
Sources

Variations for Chronic Pain

About this section
Sources

Expression for Chronic Pain

About this section
Search GEO for disease gene expression data for Chronic Pain.
Sources

Pathways for Chronic Pain

About this section

Pathways related to Chronic Pain according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
GABAergic synapse 37
Show member pathways
 11.77 CACNA1B CNR1 OPRM1 PTGS2
2
Calcium signaling pathway 37
Show member pathways
 11.7 CACNA1B P2RX4 P2RX7
3
Neuroscience 4
11.7 CNR1 COMT DLG2 OPRM1 P2RX4 P2RX7
4
Ca, cAMP and Lipid Signaling 4
11.44 CNR1 P2RX4 P2RX7
5
Celecoxib Pathway, Pharmacodynamics 61
11.13 CACNA1B PTGS2
6
Ibuprofen Pathway, Pharmacodynamics 61
10.77 CNR1 PTGS2
Sources

GO Terms for Chronic Pain

About this section

Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CACNA1B CNR1 COMT DLG2 OPRM1 P2RX4
2 neuron projection GO:0043005 9.65 DLG2 OPRM1 PTGS2
3 neuronal cell body GO:0043025 9.63 CACNA1B P2RX4 P2RX7
4 synapse GO:0045202 9.56 CACNA1B DLG2 P2RX4 P2RX7
5 presynapse GO:0098793 9.49 CACNA1B P2RX7
6 dendrite GO:0030425 9.46 CACNA1B COMT OPRM1 P2RX4
7 neuromuscular junction GO:0031594 9.43 DLG2 P2RX7
8 integral component of nuclear inner membrane GO:0005639 9.32 P2RX4 P2RX7
9 postsynapse GO:0098794 9.13 OPRM1 P2RX4 P2RX7
10 axon GO:0030424 9.02 CNR1 COMT DLG2 OPRM1 P2RX4
11 membrane GO:0016020 10.01 CACNA1B CNR1 COMT DLG2 OPRM1 P2RX4

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.79 CNR1 P2RX7 PTGS2
2 response to drug GO:0042493 9.79 COMT P2RX7 PTGS2
3 chemical synaptic transmission GO:0007268 9.77 CACNA1B DLG2 OPRM1
4 calcium ion transmembrane transport GO:0070588 9.7 CACNA1B OPRM1 P2RX4
5 apoptotic signaling pathway GO:0097190 9.65 P2RX4 P2RX7
6 response to organic cyclic compound GO:0014070 9.65 COMT P2RX7 PTGS2
7 cation transport GO:0006812 9.64 P2RX4 P2RX7
8 memory GO:0007613 9.64 CNR1 PTGS2
9 learning GO:0007612 9.63 COMT PTGS2
10 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.63 CNR1 OPRM1
11 cation transmembrane transport GO:0098655 9.62 P2RX4 P2RX7
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 P2RX4 PTGS2
13 response to cocaine GO:0042220 9.59 CNR1 OPRM1
14 response to radiation GO:0009314 9.58 OPRM1 PTGS2
15 response to morphine GO:0043278 9.58 CNR1 OPRM1
16 regulation of sensory perception of pain GO:0051930 9.57 COMT OPRM1
17 response to pain GO:0048265 9.56 CACNA1B COMT
18 regulation of sodium ion transport GO:0002028 9.55 P2RX4 P2RX7
19 response to ATP GO:0033198 9.54 P2RX4 P2RX7
20 excitatory postsynaptic potential GO:0060079 9.54 OPRM1 P2RX4 P2RX7
21 positive regulation of calcium ion transport into cytosol GO:0010524 9.51 P2RX4 P2RX7
22 regulation of blood pressure GO:0008217 9.5 CACNA1B P2RX4 PTGS2
23 cellular response to ATP GO:0071318 9.49 P2RX4 PTGS2
24 response to fluid shear stress GO:0034405 9.46 P2RX4 P2RX7
25 purinergic nucleotide receptor signaling pathway GO:0035590 9.43 P2RX4 P2RX7
26 positive regulation of prostaglandin secretion GO:0032308 9.4 P2RX4 P2RX7
27 response to lipopolysaccharide GO:0032496 9.35 CNR1 COMT OPRM1 P2RX7 PTGS2
28 membrane depolarization GO:0051899 9.33 CACNA1B P2RX4 P2RX7
29 positive regulation of fever generation GO:0031622 9.26 CNR1 PTGS2
30 sensory perception of pain GO:0019233 9.1 CNR1 DLG2 OPRM1 P2RX4 P2RX7 PTGS2

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.43 CACNA1B P2RX4 P2RX7
2 drug binding GO:0008144 9.37 CNR1 P2RX4
3 voltage-gated calcium channel activity GO:0005245 9.32 CACNA1B OPRM1
4 extracellularly ATP-gated cation channel activity GO:0004931 9.16 P2RX4 P2RX7
5 ATP-gated ion channel activity GO:0035381 8.96 P2RX4 P2RX7
6 purinergic nucleotide receptor activity GO:0001614 8.62 P2RX4 P2RX7
Sources

Sources for Chronic Pain

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA