Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CHR345
MIFTS: 52

Chronic Pain

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Chronic Pain

About this section

MalaCards integrated aliases for Chronic Pain:

Name: Chronic Pain 54 29 6 43
Pain - Chronic 54

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases Mental diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Chronic Pain

About this section
NINDS : 54 While acute pain is a normal sensation triggered in the nervous system to alert you to possible injury and the need to take care of yourself, chronic pain is different. Chronic pain persists. Pain signals keep firing in the nervous system for weeks, months, even years. There may have been an initial mishap -- sprained back, serious infection, or there may be an ongoing cause of pain -- arthritis, cancer, ear infection, but some people suffer chronic pain in the absence of any past injury or evidence of body damage. Many chronic pain conditions affect older adults. Common chronic pain complaints include headache, low back pain, cancer pain, arthritis pain, neurogenic pain (pain resulting from damage to the peripheral nerves or to the central nervous system itself), psychogenic pain (pain not due to past disease or injury or any visible sign of damage inside or outside the nervous system).  A person may have two or more co-existing chronic pain conditions.  Such conditions can include chronic fatigue syndrome, endometriosis, fibromyalgia, inflammatory bowel disease, interstitial cystitis, temporomandibular joint dysfunction, and vulvodynia.  It is not known whether these disorders share a common cause.

MalaCards based summary : Chronic Pain, also known as pain - chronic, is related to opioid addiction and pain agnosia. An important gene associated with Chronic Pain is USH2A (Usherin), and among its related pathways/superpathways are GABAergic synapse and Neuroscience. The drugs Cycloserine and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and testes, and related phenotypes are homeostasis/metabolism and integument

MedlinePlus : 43 Pain is a signal in your nervous system that something may be wrong. It is an unpleasant feeling, such as a prick, tingle, sting, burn, or ache. Pain may be sharp or dull. You may feel pain in one area of your body, or all over. There are two types: acute pain and chronic pain. Acute pain lets you know that you may be injured or a have problem you need to take care of. Chronic pain is different. The pain may last for weeks, months, or even years. The original cause may have been an injury or infection. There may be an ongoing cause of pain, such as arthritis or cancer. In some cases there is no clear cause. Environmental and psychological factors can make chronic pain worse. Many older adults have chronic pain. Women also report having more chronic pain than men, and they are at a greater risk for many pain conditions. Some people have two or more chronic pain conditions. Chronic pain is not always curable, but treatments can help. There are drug treatments, including pain relievers. There are also non-drug treatments, such as acupuncture, physical therapy, and sometimes surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 75 Chronic pain is pain that lasts a long time. In medicine, the distinction between acute and chronic pain... more...

Sources

Related Diseases for Chronic Pain

About this section

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Chronic Pain via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 574)
# Related Disease Score Top Affiliating Genes
1 opioid addiction 31.8 OPRM1 COMT
2 pain agnosia 30.8 OPRM1 CNR1
3 withdrawal disorder 30.1 OPRM1 CNR1
4 disease of mental health 30.0 OPRM1 COMT CNR1
5 cannabis dependence 30.0 COMT CNR1
6 polysubstance abuse 29.7 COMT CNR1
7 somatoform disorder 29.7 OPRM1 COMT
8 alcohol dependence 29.6 OPRM1 COMT CNR1
9 morphine dependence 29.4 PTGS2 OPRM1
10 neonatal abstinence syndrome 29.4 OPRM1 COMT
11 chronic pain requiring intraspinal analgesia 12.3
12 fibromyalgia 11.7
13 complex regional pain syndrome 11.5
14 paine syndrome 11.5
15 trigeminal neuralgia 11.5
16 hidradenitis suppurativa 11.4
17 ehlers-danlos syndrome 11.4
18 interstitial cystitis 11.4
19 occipital neuralgia 11.4
20 headache 11.3
21 sickle cell disease 11.3
22 reflex sympathetic dystrophy 11.3
23 myofascial pain syndrome 11.3
24 causalgia 11.3
25 rheumatoid arthritis 11.3
26 osteoporosis 11.2
27 cauda equina syndrome 11.2
28 frozen shoulder 11.2
29 exostosis 11.2
30 melorheostosis 11.1
31 amyotrophy, hereditary neuralgic 11.0
32 corticosteroid-binding globulin deficiency 11.0
33 adiposis dolorosa 10.9
34 brachyolmia type 3 10.9
35 buschke-ollendorff syndrome 10.9
36 polycystic kidney disease 1 with or without polycystic liver disease 10.9
37 stiff-person syndrome 10.9
38 intervertebral disc disease 10.9
39 hypophosphatasia 10.9
40 neurilemmomatosis 10.9
41 pudendal neuralgia 10.9
42 anterior cutaneous nerve entrapment syndrome 10.9
43 back pain 10.8
44 malonyl-coa decarboxylase deficiency 10.8
45 dientamoebiasis 10.8
46 spinal cord injury 10.6
47 depression 10.6
48 inguinal hernia 10.6
49 anxiety 10.6
50 substance abuse 10.5

Graphical network of the top 20 diseases related to Chronic Pain:



Diseases related to Chronic Pain
Sources

Symptoms & Phenotypes for Chronic Pain

About this section

MGI Mouse Phenotypes related to Chronic Pain:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 CACNA1B CNR1 COMT CPT2 OPRM1 P2RX4
2 integument MP:0010771 9.43 CACNA1B CNR1 DLG2 OPRM1 PTGS2 VGF
3 nervous system MP:0003631 9.28 CACNA1B CNR1 COMT DLG2 OPRM1 P2RX4
Sources

Drugs & Therapeutics for Chronic Pain

About this section

Drugs for Chronic Pain (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 582)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cycloserine Approved Phase 4 68-41-7 6234 401
2
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Palonosetron Approved, Investigational Phase 4 119904-90-4, 135729-61-2, 135729-56-5 148211
6
Dezocine Approved, Investigational Phase 4 53648-55-8 3033053 40841
7
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
8
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
10
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
11
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
12
Oxymorphone Approved, Investigational, Vet_approved Phase 4 76-41-5 5284604
13
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
14
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
15
Phenobarbital Approved, Investigational Phase 4 50-06-6 4763
16
Amphetamine Approved, Illicit, Investigational Phase 4 300-62-9 5826 3007
17
Norepinephrine Approved Phase 4 51-41-2 439260
18
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
19
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
20
Levomilnacipran Approved, Investigational Phase 4 96847-54-0
21
Esketamine Approved, Investigational Phase 4 33643-46-8
22
Polidocanol Approved Phase 4 9002-92-0
23
Ketoprofen Approved, Vet_approved Phase 4 22071-15-4 3825
24
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
25
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
26
Dihydrocodeine Approved, Illicit Phase 4 125-28-0
27
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
28
Aceclofenac Approved, Investigational Phase 4 89796-99-6
29
Propranolol Approved, Investigational Phase 4 525-66-6 4946
30
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
31
Pantoprazole Approved Phase 4 102625-70-7 4679
32
Flunarizine Approved Phase 4 52468-60-7 941361
33
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
34
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
35
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
36
Desipramine Approved, Investigational Phase 4 50-47-5 2995
37
Phenol Approved, Experimental Phase 4 108-95-2 996
38
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
39
Iodine Approved, Investigational Phase 4 7553-56-2 807
40
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
41
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
42
Meperidine Approved Phase 4 57-42-1 4058
43
Prazosin Approved Phase 4 19216-56-9 4893
44
Nicotine Approved Phase 4 54-11-5 942 89594
45
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
46
Remifentanil Approved Phase 4 132875-61-7 60815
47
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
48
Ibuprofen Approved Phase 4 15687-27-1 3672
49
Tibolone Approved, Investigational Phase 4 5630-53-5
50
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109

Interventional clinical trials:

(show top 50) (show all 3305)
# Name Status NCT ID Phase Drugs
1 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
2 N-of-1 Randomised Trials to Assess the Efficacy of Ultra-micronized Palmitoylethanolamide (Um-PEA) in Geriatric Patients With Chronic Pain Unknown status NCT02699281 Phase 4 ultra-micronized palmitoylethanolamide;Placebo
3 The Effect of Angiotensin II Receptor Antagonists on Acute and Chronic Postoperative Pain in Patients Treated for Hypertension. Unknown status NCT02513979 Phase 4 Angiotensin type II receptor antagonists
4 Brain Mechanisms For Clinical Placebo in Chronic Pain: A Randomized Clinical Trial of Placebo, Active Treatment, and No Treatment in Chronic Back Pain Unknown status NCT02986334 Phase 4 Naproxen;Omeprazole;Placebo
5 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
6 Investigating the Effect of Intra-operative Infiltration With Local Anaesthesia on the Development of Chronic Postoperative Pain After Inguinal Hernia Repair. A Randomized Placebo Controlled Triple Blinded and Group Sequential Study Design Unknown status NCT00484731 Phase 4
7 Investigator Initiated Trial- Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty. Comparison of Spinal Cord Stimulation and Comprehensive Medical Management Unknown status NCT01616342 Phase 4
8 Chronic Significant Pain and Functional Outcome After Laparoscopic Versus Open Groin Hernia Mesh Repair: Design of a Randomized Controlled Clinical Trial Unknown status NCT00625534 Phase 4
9 Effects of Calot's Triangle Block for Postoperative Analgesia in Patients Undergoing Laparoscopic Cholecystectomy: a Prospective, Randomized, Double-blind, Controlled, Clinical Trial Unknown status NCT02300480 Phase 4
10 Therapeutic Effects of Video Game Play Therapy on Patients With Chronic Low Back Pain:Randomized-Controlled Clinical Trail Unknown status NCT02125968 Phase 4
11 The Effect of Remifentanil on Established Capsaicin-Induced Hyperalgesia in Human Volunteers Unknown status NCT00789386 Phase 4 Remifentanil;Midazolam
12 The Effect of High-dose Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers (HighDose RemiSun) Unknown status NCT01015482 Phase 4 Remifentanil;Midazolam
13 The Effect of Remifentanil on Established Sunburn-induced Hyperalgesia in Human Volunteers Unknown status NCT00811837 Phase 4 Midazolam;Remifentanil
14 Abdominal Midline Incisional Hernia Repair and Functional Outcome: Randomized Controlled Trial to Compare Open and Laparoscopic Surgical Unknown status NCT00625053 Phase 4
15 Effect of Three Therapeutic Strategies on the Restriction of the Participation of Patients With a Chronic Back Pain : Multidisciplinary is it the Key Component ? Unknown status NCT02030171 Phase 4
16 The Effect of Intranasal Oxytocin on Pain Sensitivity and Threshold: A Randomized, Double Blinded, Crossover Volunteer Study Unknown status NCT02550093 Phase 4 Normal Saline;Oxytocin
17 The Effect of High-dose Remifentanil on Established Capsaicin-induced Hyperalgesia in Human Volunteers Unknown status NCT00886106 Phase 4 Remifentanil;Midazolam
18 Comparison of Two Kinds of Postoperative Analgesia After Amputation:a Randomized Clinical Trial Unknown status NCT02114463 Phase 4 ropivacaine;flurbiprofen
19 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
20 Therapeutic Effects of Monochromatic Infrared Energy Therapy on Patients With Chronic Low Back Pain: A Double-Blind, Randomized, Placebo-Controlled Study Unknown status NCT01920971 Phase 4
21 Continuous Pre-uterine Wound Infiltration Versus Intrathecal Morphine for Postoperative Analgesia After Cesarean Section. Controlled Comparative Study. Unknown status NCT02279628 Phase 4 Ropivacaine;Morphine
22 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
23 Multicentre Randomised Controled Trial Comparing the Effect of a New Self-gripping Lightweight Polyester Mesh and a Normal Sutured Lightweight Polyester Mesh on the Incidence of Chronic Inguinodynia in Lichtenstein Hernioplasty. Unknown status NCT01830452 Phase 4
24 Intra-articular Botulinum Toxin Type A Versus Corticosteroids: a Clinical Trial in Osteoarthritis of Knees Unknown status NCT02829281 Phase 4 Botulinum Toxin Type A;Triamcinolone hexacetonide;Saline
25 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
26 Efficacy of Regional Analgesia Techniques (Quadratus Lumborum Block and Transversus Abdominis Plane Block) in Acute and Chronic Pain Treatment in Patients After Cesarean Delivery Unknown status NCT03244540 Phase 4 Ropivacaine;Paracetamol;Metamizol;Ketoprofen;Bupivacaine
27 Levobupivacaine Prolonged Wound Infusion for Postoperative Pain Relief After Breast Surgery Unknown status NCT02035904 Phase 4 Levobupivacaine PCIA (Patient Controlled Intrawound Analgesia);saline;Levobupivacaine continuous infusion;morphine;Patrol
28 Effects of Pregabalin on Mechanical Hyperalgesia - EPOM Unknown status NCT00310583 Phase 4 Pregabalin
29 Eight Week Feasibility Study Enrolling Dry Eye Subjects Confirmed by Four of Seven Dianostic Markers Responding to Nutritional Therapy Unknown status NCT01561040 Phase 4
30 Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain Unknown status NCT02339662 Phase 4 Gabapentin;Amitriptyline
31 Analgesic Effects of Local Anesthetic Serratus Plane Infiltration for Total Mastectomy Surgery: A Pilot Study Unknown status NCT02893384 Phase 4 Local Anesthetic Injection above the serratus anterior
32 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
33 The Impact of Botulinum Toxin Injection in the Frontalis on Brow Height and Morphology: A Randomized Trial Unknown status NCT03186001 Phase 4 Abobotulinum toxin A
34 Comparison of Self Gripping Semi-resorbable Mesh (PROGRIP) With Polypropylene Mesh in Open Inguinal Hernia Repair - a Randomized Study Unknown status NCT00960011 Phase 4
35 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
36 D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression Unknown status NCT02772211 Phase 4 Ketamine;D-cycloserine;Placebo
37 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Completed NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
38 Effectiveness of the Precision Spinal Cord Stimulation System in Patients With Failed Back Surgery Syndrome and Axial Low Back Pain Completed NCT00205868 Phase 4
39 Evaluation in Efficacy and Safety of Fentanyl-TTS (Durogesic® D-Trans) for Treatment of Chronic Pain Completed NCT01902524 Phase 4 Fentanyl-TTS
40 Effects of Thoracic Paravertebral Blockade on Acute and Chronic Pain After Video Assisted Thoracoscopic Surgery (VATS) - A Randomized, Clinical Trial Completed NCT02302586 Phase 4 Thoracic paravertebral block (TPVB);Patient Controlled Analgesia (IV PCA)
41 The Effect of Pulse Width on the Treatment of Chronic Low Back Pain With Spinal Cord Stimulation Completed NCT00399516 Phase 4
42 Development and Evaluation of a Methadone Protocol for Severe Chronic Pain Management Completed NCT02335398 Phase 4 Methadone
43 Observational Registry: The Effectiveness of Pain Management Using the ARCHIMEDES® Implantable Constant-Flow Infusion Pump System for Intrathecal Delivery Completed NCT00196053 Phase 4
44 A CTSC Clinical Research Center Study: A Comparison of the Addiction Liability of Hydrocodone and Sustained Release Morphine Completed NCT00314340 Phase 4 ER Morphine;hydrocodone plus acetaminophen;placebo
45 A Randomised Clinical Trial Evaluating the Effect of Remifentanil vs Fentanyl During Cardiac Surgery on the Incidence of Chronic Thoracic Pain Completed NCT02031016 Phase 4 Fentanyl;Remifentanil;Fentanyl
46 Pain Reducing Effect of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients With Chronic Low Back Pain or Chronic Lumbo-radiculalgia and Followed in Pain Treatment Centers Completed NCT00452010 Phase 4
47 Benefit of Laparoscopic Adhesiolysis Completed NCT02839564 Phase 4
48 Evaluation Study of Efficacy and Safety of TTS-Fentanyl in Chronic Non-Malignant Pain Completed NCT01816243 Phase 4 TTS-Fentanyl;Morphine
49 Perioperative Dexamethasone to Promote Systemic Pro-Resolution Phenotype for Prevention of Acute and Chronic Pain Post-Total Knee Arthroplasty. Completed NCT02271698 Phase 4 Dexamethasone
50 A Randomized Controlled Trial Comparing Buprenorphine and Methadone for Treatment in Opioid Dependent Chronic Back Pain Patients Completed NCT01559454 Phase 4 Methadone;Buprenorphine/naloxone

Search NIH Clinical Center for Chronic Pain

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Aminohippuric acid
Amphetamine
Desipramine
Morphine
Nortriptyline
Sources

Genetic Tests for Chronic Pain

About this section

Genetic tests related to Chronic Pain:

# Genetic test Affiliating Genes
1 Chronic Pain 29
Sources

Anatomical Context for Chronic Pain

About this section

MalaCards organs/tissues related to Chronic Pain:

41
Spinal Cord, Brain, Testes, Breast, Cortex, Bone, Prostate
Sources

Publications for Chronic Pain

About this section

Articles related to Chronic Pain:

(show top 50) (show all 30457)
# Title Authors PMID Year
1
Acupoint injection for nonspecific chronic low back pain: A protocol of systematic review. 17
31335709 2019
2
Radiofrequency neurotomy in chronic lumbar and sacroiliac joint pain: A meta-analysis. 17
31261580 2019
3
Acupuncture for lumbar myofascial pain Protocol for a systematic review of randomized controlled trials. 17
31261598 2019
4
Intrathecal Drug Delivery. 38
31435916 2020
5
Diverse TRPV1 responses to cannabinoids. 38
31096838 2019
6
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. 38
30696302 2019
7
Pain management using nanotechnology approaches. 38
30688094 2019
8
Cannabinoid interactions with ion channels and receptors. 38
31088312 2019
9
Adaptation effects of medial forebrain bundle micro-electrical stimulation. 38
30916601 2019
10
Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. 38
30672394 2019
11
Pain inhibition through transplantation of fetal neuronal progenitors into the injured spinal cord in rats. 38
31290460 2019
12
Existing and emerging applications for the neuromodulation of nerve activity through targeted delivery of electric stimuli. 38
31092102 2019
13
TRPM2 participates the transformation of acute pain to chronic pain during injury-induced neuropathic pain. 38
31120580 2019
14
Does diet play a role in reducing nociception related to inflammation and chronic pain? 38
31301604 2019
15
Psychometric properties of the Functional Disability Inventory for assessing Pain-related disability in children from the community. 38
29697002 2019
16
Lifespan Development: Symptoms Experienced by Individuals with Neurofibromatosis Type 1 Associated Plexiform Neurofibromas from Childhood into Adulthood. 38
30298332 2019
17
Insight into the possible role of miR-214 in primary osteoporosis via osterix. 38
31056782 2019
18
Self-regulatory ability, fatigue, and the experience of pain: Mechanistic insights from pain-free undergraduates. 38
31049991 2019
19
Role of RGS12 in the differential regulation of kappa opioid receptor-dependent signaling and behavior. 38
31141817 2019
20
Upregulation of matrix metalloproteinase-9/2 in the wounded tissue, dorsal root ganglia, and spinal cord is involved in the development of postoperative pain. 38
31075261 2019
21
Rate and extent of mitragynine and 7-hydroxymitragynine blood-brain barrier transport and their intra-brain distribution: the missing link in pharmacodynamic studies. 38
30088322 2019
22
Acute alcohol effects on conditioned pain modulation, but not temporal summation of pain. 38
31276454 2019
23
Development and course of chronic widespread pain: the role of time and pain characteristics (the HUNT pain study). 38
30985619 2019
24
Pathophysiology, prevention, and treatment of medication overuse headache. 38
31174999 2019
25
Chronic Pain Management in the Elderly. 38
31337484 2019
26
Assessment and Management of Chronic Pain in the Seriously Ill. 38
31375184 2019
27
Development and validation of the Treatment Expectations in Chronic Pain Scale. 38
30989756 2019
28
Rat ultrasonic vocalizations as a measure of the emotional component of chronic pain. 38
31373964 2019
29
What cancer patients actually know regarding medical cannabis? A cross-sectional survey with a critical analysis of the current attitudes. 38
31042135 2019
30
Neural network-based alterations during repetitive heat pain stimulation in major depression. 38
31320209 2019
31
Understanding the link between substance use and chronic pain: A qualitative study among people who use illicit drugs in Montreal, Canada. 38
31301552 2019
32
Reduced sensitivity to ethanol and excessive drinking in a mouse model of neuropathic pain. 38
31237390 2019
33
Donor Site Morbidities of Iliac Crest Bone Graft in Craniofacial Surgery: A Systematic Review. 38
30562201 2019
34
Further Examination of the Pain Stages of Change Questionnaires Among Chronic Low Back Pain Patients: Long-term Predictive Validity of Pretreatment and Posttreatment Change Scores and Stability of Posttreatment Scores. 38
31149934 2019
35
Opioid Prescriptions for Acute and Chronic Pain Management Among Medicaid Beneficiaries. 38
31377093 2019
36
Persistent Nociception Facilitates the Extinction of Morphine-Induced Conditioned Place Preference. 38
31425234 2019
37
Ehlers-Danlos syndrome and other heritable connective tissue disorders that impact pregnancies can be detected using next-generation DNA sequencing. 38
31250196 2019
38
Effect of alcohol on chronic pelvic pain and prostatic inflammation in a mouse model of experimental autoimmune prostatitis. 38
31233226 2019
39
Low-dose ketamine in painful orthopaedic surgery: a systematic review and meta-analysis. 38
31327465 2019
40
Role of brain imaging in disorders of brain-gut interaction: a Rome Working Team Report. 38
31175206 2019
41
The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain. 38
31228456 2019
42
Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model. 38
31158744 2019
43
Motor adaptation varies between individuals in the transition to sustained pain. 38
31095094 2019
44
Molecular mechanisms of action of systemic lidocaine in acute and chronic pain: a narrative review. 38
31303268 2019
45
Improving Distress and Behaviors for Parents of Adolescents With Chronic Pain Enrolled in an Intensive Interdisciplinary Pain Program. 38
31205071 2019
46
The impact of health literacy on health outcomes in individuals with chronic pain: a cross-sectional study. 38
30878145 2019
47
Evaluation of an innovative tele-education intervention in chronic pain management for primary care clinicians practicing in underserved areas. 38
29991316 2019
48
'Dis-comfort eating': An investigation into the use of food as a coping strategy for the management of chronic pain. 38
31145944 2019
49
Spinal IL-33/ST2 signaling mediates chronic itch in mice through the astrocytic JAK2-STAT3 cascade. 38
31087583 2019
50
Incidence of chronic pain 6 y after major trauma. 38
31012096 2019
Sources

Variations for Chronic Pain

About this section

ClinVar genetic disease variations for Chronic Pain:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CPT2 NM_000098.3(CPT2): c.149C> A (p.Pro50His) single nucleotide variant Pathogenic rs28936375 1:53662764-53662764 1:53197092-53197092
2 USH2A NM_206933.3(USH2A): c.2299del (p.Glu767fs) deletion Pathogenic/Likely pathogenic rs80338903 1:216420437-216420437 1:216247095-216247095
3 MYH8 NM_002472.3(MYH8): c.5743A> G (p.Ile1915Val) single nucleotide variant Uncertain significance 17:10293842-10293842 17:10390525-10390525
4 USH2A NM_206933.3(USH2A): c.5003G> T (p.Gly1668Val) single nucleotide variant Uncertain significance 1:216258204-216258204 1:216084862-216084862
Sources

Expression for Chronic Pain

About this section
Search GEO for disease gene expression data for Chronic Pain.
Sources

Pathways for Chronic Pain

About this section

Pathways related to Chronic Pain according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
GABAergic synapse 37
Show member pathways
 11.77 PTGS2 OPRM1 CNR1 CACNA1B
2
Neuroscience 4
11.63 PTGS2 P2RX4 OPRM1 DLG2 COMT CNR1
3
Ibuprofen Pathway, Pharmacodynamics 61
10.6 PTGS2 CNR1
Sources

GO Terms for Chronic Pain

About this section

Cellular components related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 P2RX4 OPRM1 COMT CACNA1B
2 axon GO:0030424 9.02 P2RX4 OPRM1 DLG2 COMT CNR1

Biological processes related to Chronic Pain according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of nitric oxide biosynthetic process GO:0045429 9.52 PTGS2 P2RX4
2 response to cocaine GO:0042220 9.51 OPRM1 CNR1
3 calcium ion transmembrane transport GO:0070588 9.5 P2RX4 OPRM1 CACNA1B
4 response to radiation GO:0009314 9.49 PTGS2 OPRM1
5 regulation of sensory perception of pain GO:0051930 9.48 OPRM1 COMT
6 response to morphine GO:0043278 9.46 OPRM1 CNR1
7 membrane depolarization GO:0051899 9.43 P2RX4 CACNA1B
8 regulation of blood pressure GO:0008217 9.43 PTGS2 P2RX4 CACNA1B
9 response to pain GO:0048265 9.4 COMT CACNA1B
10 cellular response to ATP GO:0071318 9.37 PTGS2 P2RX4
11 response to lipopolysaccharide GO:0032496 9.26 PTGS2 OPRM1 COMT CNR1
12 positive regulation of fever generation GO:0031622 9.16 PTGS2 CNR1
13 sensory perception of pain GO:0019233 9.02 PTGS2 P2RX4 OPRM1 DLG2 CNR1

Molecular functions related to Chronic Pain according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated calcium channel activity GO:0005245 8.62 OPRM1 CACNA1B
Sources

Sources for Chronic Pain

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....