MCID: CHR094
MIFTS: 29

Chronic Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Chronic Polyneuropathy

MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5221
NCIt 49 C36071
UMLS 71 C1167650

Summaries for Chronic Polyneuropathy

MalaCards based summary : Chronic Polyneuropathy is related to osteosclerotic myeloma and demyelinating polyneuropathy. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways is Lysine degradation. The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related phenotypes are homeostasis/metabolism and behavior/neurological

Related Diseases for Chronic Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 osteosclerotic myeloma 30.1 MAG CD40LG
2 demyelinating polyneuropathy 29.9 PMP22 MAG FCGR2B
3 monoclonal gammopathy of uncertain significance 29.8 MAG CD40LG
4 polyradiculoneuropathy 29.8 PMP22 MAG
5 mononeuritis multiplex 29.7 PMP22 MAG CD40LG
6 polyneuropathy 29.6 PMP22 MAG GJB1 FCGR2B CD40LG
7 charcot-marie-tooth disease, demyelinating, type 1b 29.4 PMP22 GJB1
8 hereditary neuropathies 29.2 PMP22 MAG GJB1
9 neuropathy, hereditary, with liability to pressure palsies 29.2 PMP22 MAG GJB1
10 peripheral nervous system disease 28.9 PMP22 NT5C3A MAG GJB1 CD40LG
11 sensory peripheral neuropathy 28.8 PMP22 MAG GJB1 CD40LG
12 giant axonal neuropathy 1, autosomal recessive 11.2
13 cerebral lymphoma 10.3 MAG CD40LG
14 aleutian mink disease 10.3 PHYH CD40LG
15 waldenstroem's macroglobulinemia 10.3 MAG CD40LG
16 postpoliomyelitis syndrome 10.3 PMP22 CD40LG
17 plexopathy 10.3 PMP22 CD40LG
18 brachial plexus neuropathy 10.3 PMP22 CD40LG
19 bell's palsy 10.3 PMP22 CD40LG
20 cranial nerve palsy 10.3 NT5C3A CD40LG
21 polyradiculopathy 10.2 PMP22 CD40LG
22 multifocal motor neuropathy 10.2 FCGR2B CD40LG
23 facial nerve disease 10.2 NT5C3A CD40LG
24 facial paralysis 10.2 NT5C3A CD40LG
25 rhizomelic chondrodysplasia punctata, type 3 10.2 PHYH PEX7
26 rhizomelic chondrodysplasia punctata, type 2 10.2 PHYH PEX7
27 autoimmune disease of urogenital tract 10.2 FCGR2B CD40LG
28 lymphoplasmacytic lymphoma 10.2 MAG CD40LG
29 primary thrombocytopenia 10.1 FCGR2B CD40LG
30 rhizomelic chondrodysplasia punctata, type 1 10.1 PHYH PEX7
31 blood protein disease 10.1 MAG CD40LG
32 thrombocytopenia due to platelet alloimmunization 10.1 FCGR2B CD40LG
33 asymmetric motor neuropathy 10.1 PMP22 MAG CD40LG
34 mononeuritis of upper limb and mononeuritis multiplex 10.1 PMP22 MAG CD40LG
35 mononeuropathy 10.1 PMP22 MAG CD40LG
36 goodpasture syndrome 10.1 FCGR2B CD40LG
37 autoimmune disease of peripheral nervous system 10.1 PMP22 MAG CD40LG
38 guillain-barre syndrome 10.1 PMP22 MAG CD40LG
39 hyperlysinemia, type i 10.1 DHTKD1 AASS
40 inclusion conjunctivitis 10.1 WDR13 CD40LG
41 2-aminoadipic 2-oxoadipic aciduria 10.1 DHTKD1 AASS
42 chondrodysplasia punctata syndrome 10.1 PHYH PEX7
43 autoimmune disease of blood 10.1 FCGR2B CD40LG
44 demyelinating disease 10.1 PMP22 MAG CD40LG
45 peroxisomal biogenesis disorder 10.1 PHYH PEX7
46 neuropathy 10.1
47 refsum disease, classic 10.0 PHYH PEX7
48 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
49 thrombocytopenic purpura, autoimmune 10.0 FCGR2B CD40LG
50 dowling-degos disease 1 9.9

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy

Symptoms & Phenotypes for Chronic Polyneuropathy

MGI Mouse Phenotypes related to Chronic Polyneuropathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 AASS CD40LG DHTKD1 FCGR2B GJB1 MAG
2 behavior/neurological MP:0005386 9.92 DHTKD1 FCGR2B GJB1 MAG PEX7 PHYH
3 immune system MP:0005387 9.7 AASS CD40LG FCGR2B GJB1 MAG PEX7
4 liver/biliary system MP:0005370 9.35 DHTKD1 FCGR2B GJB1 PEX7 PHYH
5 nervous system MP:0003631 9.23 CD40LG DHTKD1 FCGR2B GJB1 MAG PEX7

Drugs & Therapeutics for Chronic Polyneuropathy

Drugs for Chronic Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3 174722-31-7 10201696
2 Immunologic Factors Phase 3
3 Antirheumatic Agents Phase 3
4 Antineoplastic Agents, Immunological Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-blind Randomized Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy Completed NCT00259974 Phase 3 Rituximab
2 A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Three Doses of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Completed NCT00229437 Phase 2 TAK-128;TAK-128;TAK-128;Placebo
3 An Open-Label, Multi-Center Study to Evaluate the Safety of Long-Term Administration of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Terminated NCT00756041 Phase 2 TAK-128

Search NIH Clinical Center for Chronic Polyneuropathy

Genetic Tests for Chronic Polyneuropathy

Anatomical Context for Chronic Polyneuropathy

MalaCards organs/tissues related to Chronic Polyneuropathy:

40
Skin, Bone Marrow, Bone, Cerebellum, Liver, Lung, Thyroid

Publications for Chronic Polyneuropathy

Articles related to Chronic Polyneuropathy:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Thrombosis revealing POEMS syndrome. About a case. 61
32162605 2020
2
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 61
30739577 2020
3
Diagnostic value of symptoms in chronic polyneuropathy: The Erasmus Polyneuropathy Symptom Score. 61
31172622 2019
4
Causes of chronic neuropathies: a single-center experience. 61
31001716 2019
5
Statins do not increase risk of polyneuropathy: A case-control study and literature review. 61
30737334 2019
6
CSF cystatin C and diffusion tensor imaging parameters as biomarkers of upper motor neuron degeneration in amyotrophic lateral sclerosis. 61
30016754 2018
7
Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. 61
29687564 2018
8
Polyneuropathy relates to impairment in daily activities, worse gait, and fall-related injuries. 61
28566544 2017
9
Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up. 61
28238650 2017
10
Prevalence of polyneuropathy in the general middle-aged and elderly population. 61
27683845 2016
11
The epidemiology and risk factors of chronic polyneuropathy. 61
26700499 2016
12
Peripheral neuropathies. 61
27637963 2016
13
Phytol in a pharma-medico-stance. 61
26296761 2015
14
[Hypomyelination with atrophy of the basal ganglia and cerebellum. Contribution of two new cases to a recently reported entity]. 61
24504878 2014
15
Infectious neuropathies. 61
23945279 2013
16
A serine synthesis defect presenting with a Charcot-Marie-Tooth-like polyneuropathy. 61
22393170 2012
17
Recurrent demyelination and remyelination in 37 young Bengal cats with polyneuropathy. 61
21689154 2011
18
Refsum's Disease-Use of the Intestinal Lipase Inhibitor, Orlistat, as a Novel Therapeutic Approach to a Complex Disorder. 61
20871815 2011
19
[Chronic demyelinating polyneuropathy and B6 hypervitaminosis]. 61
20627481 2010
20
Adult Refsum disease: a form of tapetoretinal dystrophy accessible to therapy. 61
20850855 2010
21
[Charcot-Marie-Tooth (CMT) disease: an update]. 61
20929675 2010
22
Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy. 61
20424898 2010
23
Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. 61
19261857 2009
24
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. 61
18691815 2008
25
Cochlear implantation in Refsum's disease. 61
18698664 2008
26
Infectious neuropathy. 61
17885443 2007
27
[Chronic polyneuropathy--evaluation and diagnosis]. 61
17279107 2007
28
Chronic polyneuropathy and Lyme disease. 61
17038034 2006
29
[Bilateral papilloedema as the initial symptom of POEMS syndrome]. 61
17072808 2006
30
Pain affects the quality of life of neuropathic patients. 61
16897626 2006
31
[Churg-Strauss syndrome complicated by polyneuropathy]. 61
16784146 2006
32
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. 61
16484653 2006
33
[Removal of a tracheostomy in ventilator-dependent patients with neuromuscular disease]. 61
16272975 2005
34
[Adult Refsum disease. A retinal dystrophy with therapeutic options]. 61
15990985 2005
35
Delayed motor and sensory neuropathy in a patient with brainstem encephalitis. 61
15936038 2005
36
Q fever as a cause of pure sensory polyneuropathy -- the six-year itch: a follow-up of an indigenous Swedish case. 61
16308243 2005
37
A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes. 61
15205993 2004
38
Neurofibromatosis 1-associated neuropathies: a reappraisal. 61
15289270 2004
39
[Chronic and predominantly sensory polyneuropathy in Toroku Valley where a mining company produced arsenic]. 61
12607976 2002
40
[Hereditary neuropathy with liability to pressure palsies: study of six Spanish families]. 61
12072826 2002
41
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. 61
12030409 2002
42
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. 61
19078654 2001
43
Diagnostic yield by testing small fiber function in patients examined for polyneuropathy. 61
11800044 2001
44
Prospective follow-up study of chronic polyneuropathy of undetermined cause. 61
11494273 2001
45
Guillain-Barré syndrome following herpes zoster in a patient with systemic sclerosis. 61
24383736 2001
46
Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline. 61
11459893 2001
47
Diabetic neuropathies. 61
11345009 2001
48
[Clinical and paraclinical investigations of chronic polyneuropathies]. 61
10853550 2000
49
Quality of life in patients with axonal polyneuropathy. 61
10787114 2000
50
[Chronic hereditary ataxic polyneuropathy]. 61
11050807 2000

Variations for Chronic Polyneuropathy

Expression for Chronic Polyneuropathy

Search GEO for disease gene expression data for Chronic Polyneuropathy.

Pathways for Chronic Polyneuropathy

Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.41 DHTKD1 AASS

GO Terms for Chronic Polyneuropathy

Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.96 PHYH PEX7
2 compact myelin GO:0043218 8.62 PMP22 MAG

Sources for Chronic Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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