MCID: CHR094
MIFTS: 26

Chronic Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Chronic Polyneuropathy

MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5221
NCIt 50 C36071
UMLS 73 C1167650

Summaries for Chronic Polyneuropathy

MalaCards based summary : Chronic Polyneuropathy is related to osteosclerotic myeloma and giant axonal neuropathy 1, autosomal recessive. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways is Primary immunodeficiency. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Related phenotype is nervous system.

Related Diseases for Chronic Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 osteosclerotic myeloma 28.0 CD40LG CD79A MAG MYOM2
2 giant axonal neuropathy 1, autosomal recessive 10.9
3 autoimmune disease of central nervous system 10.8 CD40LG MAG
4 mononeuritis multiplex 10.8 CD40LG MAG
5 miller fisher syndrome 10.8 CD40LG MAG
6 encephalitozoonosis 10.7 CD40LG PHYH
7 aleutian mink disease 10.6 CD40LG PHYH
8 tolosa-hunt syndrome 10.5 CD40LG NF1
9 multifocal motor neuropathy 10.5 CD40LG FCGR2B
10 selective igg deficiency disease 10.4 CD40LG CD79A
11 c1q nephropathy 10.4 CD40LG CD79A
12 meningovascular neurosyphilis 10.4 CD40LG CD79A
13 alpha chain disease 10.4 CD40LG CD79A
14 brill-zinsser disease 10.4 CD40LG CD79A
15 exudative glomerulonephritis 10.4 CD40LG CD79A
16 cork-handlers' disease 10.4 CD40LG CD79A
17 salpingo-oophoritis 10.4 CD40LG CD79A
18 early yaws 10.4 CD40LG CD79A
19 ventilation pneumonitis 10.4 CD40LG CD79A
20 chronic interstitial cystitis 10.4 CD40LG CD79A
21 axillary adenitis 10.4 CD40LG CD79A
22 cryofibrinogenemia 10.4 CD40LG CD79A
23 trichostrongyloidiasis 10.4 CD40LG CD79A
24 subacute bacterial endocarditis 10.4 CD40LG CD79A
25 heterophyiasis 10.4 CD40LG CD79A
26 immunoglobulin g deficiency 10.4 CD40LG CD79A
27 orbital granuloma 10.4 CD40LG CD79A
28 transient hypogammaglobulinemia of infancy 10.4 CD40LG CD79A
29 hyperglobulinemic purpura 10.4 CD40LG CD79A
30 gastroduodenitis 10.4 CD40LG CD79A
31 bacterial conjunctivitis 10.4 CD40LG CD79A
32 heavy chain disease 10.4 CD40LG CD79A
33 ophthalmia neonatorum 10.4 CD40LG CD79A
34 immunoglobulin a deficiency 1 10.4 CD40LG CD79A
35 parotid disease 10.4 CD40LG CD79A
36 cerebral arteritis 10.4 CD40LG CD79A
37 selective immunoglobulin deficiency disease 10.4 CD40LG CD79A
38 geniculate herpes zoster 10.4 CD40LG CD79A
39 erythema elevatum diutinum 10.4 CD40LG CD79A
40 sporotrichosis 10.4 CD40LG CD79A
41 fallopian tube disease 10.4 CD40LG CD79A
42 hyperimmunoglobulin syndrome 10.4 CD40LG CD79A
43 congenital syphilis 10.4 CD40LG CD79A
44 monoclonal paraproteinemia 10.4 CD40LG CD79A
45 salpingitis 10.4 CD40LG CD79A
46 ocular toxoplasmosis 10.4 CD40LG CD79A
47 dysgammaglobulinemia 10.4 CD40LG CD79A
48 congenital hypogammaglobulinemia 10.4 CD40LG CD79A
49 acute maxillary sinusitis 10.4 CD40LG CD79A
50 spinocerebellar ataxia, autosomal recessive 10 10.4 CD40LG CD79A

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy

Symptoms & Phenotypes for Chronic Polyneuropathy

MGI Mouse Phenotypes related to Chronic Polyneuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 PHGDH PHYH CD40LG CD79A FCGR2B MAG

Drugs & Therapeutics for Chronic Polyneuropathy

Drugs for Chronic Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Not Applicable
2 Immunoglobulins Not Applicable
3 Antibodies, Anti-Idiotypic Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Descriptive Analysis of Morphological Aspects of Nerve by Ultra-high Frequency Ultrasound (30-50MHZ) in Demyelinating Neuropathies: Inflammatory Demyelinating Polyneuropathy Chronic (IPDC), Neuropathy Multifocal Motor Block of Conducting (NMMBC) and Neuro Not yet recruiting NCT03008733 Not Applicable

Search NIH Clinical Center for Chronic Polyneuropathy

Genetic Tests for Chronic Polyneuropathy

Anatomical Context for Chronic Polyneuropathy

Publications for Chronic Polyneuropathy

Articles related to Chronic Polyneuropathy:

(show all 24)
# Title Authors Year
1
Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. ( 29687564 )
2018
2
The epidemiology and risk factors of chronic polyneuropathy. ( 26700499 )
2016
3
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. ( 18691815 )
2008
4
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. ( 16484653 )
2006
5
Chronic polyneuropathy and Lyme disease. ( 17038034 )
2006
6
Prospective follow-up study of chronic polyneuropathy of undetermined cause. ( 11494273 )
2001
7
Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline. ( 11459893 )
2001
8
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. ( 19078654 )
2001
9
Vocal cord paralysis and respiratory muscle weakness: an unusual presentation of chronic polyneuropathy. ( 9707455 )
1998
10
Detection of Borrelia burgdorferi DNA and complement membrane attack complex deposits in the sural nerve of a patient with chronic polyneuropathy and tertiary Lyme disease. ( 9236787 )
1997
11
Primary SjAPgren's syndrome in chronic polyneuropathy presenting in middle or old age. ( 7931401 )
1994
12
IgG antibody against GM1, GD1b and asialo-GM1 in chronic polyneuropathy following Mycoplasma pneumoniae infection. ( 1563451 )
1992
13
Comparison of electrodiagnostic criteria for primary demyelination in chronic polyneuropathy. ( 1944409 )
1991
14
Treatment of idiopathic chronic polyneuropathy with plasma exchange alone. ( 2352988 )
1990
15
Chronic polyneuropathy and ulcerative colitis. ( 2724650 )
1989
16
Two cases of Dandy-Walker syndrome and chronic polyneuropathy. ( 2485913 )
1989
17
Delayed chronic polyneuropathy following organophosphate poisoning: a case report. ( 2845234 )
1987
18
Humoral abnormalities in three patients with idiopathic chronic polyneuropathy. ( 3895061 )
1985
19
Chronic polyneuropathy of undetermined cause. ( 6330306 )
1984
20
Ultrastructure of the sural nerve in chronic polyneuropathy associated with Adie's syndrome. ( 4446945 )
1974
21
Familial chronic polyneuropathy with crampiform manifestations. ( 4187191 )
1969
22
Hereditary chronic polyneuropathy. Electrophysiological and pathological studies in an affected family. ( 4185983 )
1969
23
Aspects of chronic polyneuropathy associated with myeloma. ( 5707163 )
1968
24
The relation between chronic polyneuropathy and osteosclerotic myeloma. ( 6075207 )
1967

Variations for Chronic Polyneuropathy

Expression for Chronic Polyneuropathy

Search GEO for disease gene expression data for Chronic Polyneuropathy.

Pathways for Chronic Polyneuropathy

Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.19 CD40LG CD79A

GO Terms for Chronic Polyneuropathy

Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD40LG CD79A FCGR2B

Biological processes related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neural tube development GO:0021915 9.16 NF1 PHGDH
2 B cell proliferation GO:0042100 8.96 CD40LG CD79A
3 spinal cord development GO:0021510 8.62 NF1 PHGDH

Sources for Chronic Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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