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MCID: CHR094
MIFTS: 32

Chronic Polyneuropathy

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Polyneuropathy

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MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 12 15 72

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5221
NCIt 50 C36071
UMLS 72 C1167650
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Summaries for Chronic Polyneuropathy

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MalaCards based summary : Chronic Polyneuropathy is related to polyneuropathy and mononeuritis multiplex. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways are Neuroscience and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. The drugs rituximab and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung, and related phenotypes are cardiovascular system and cellular

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Related Diseases for Chronic Polyneuropathy

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Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 30.9 TTR PMP22 MAG
2 mononeuritis multiplex 30.3 MYOM2 MAG
3 polyradiculoneuropathy 30.2 PMP22 MAG
4 osteosclerotic myeloma 30.1 MYOM2 MAG
5 demyelinating polyneuropathy 29.6 TTR PMP22 MAG FCGR2B
6 peripheral nervous system disease 29.6 TTR PMP22 MYOM2 MAG
7 monoclonal gammopathy of uncertain significance 29.1 MYOM2 MAG B2M
8 amyloidosis 28.6 TTR CST3 B2M
9 giant axonal neuropathy 1, autosomal recessive 11.2
10 multifocal motor neuropathy 10.5 FCGR2B CD40LG
11 mononeuritis of upper limb and mononeuritis multiplex 10.5 MYOM2 MAG
12 plasma protein metabolism disease 10.3 MYOM2 MAG
13 mononeuropathy 10.2 PMP22 MYOM2
14 pelizaeus-merzbacher disease 10.1 PMP22 MAG
15 neurilemmoma of the fifth cranial nerve 10.1 NUMB NF1
16 trigeminal nerve neoplasm 10.1 NUMB NF1
17 neuropathy 10.1
18 aleutian mink disease 10.1 TTR PHYH CD40LG
19 chronic inflammatory demyelinating polyneuropathy 10.0
20 dowling-degos disease 1 9.9
21 indolent myeloma 9.9 MYOM2 B2M
22 extramedullary plasmacytoma 9.9 MYOM2 B2M
23 non-secretory myeloma 9.9 MYOM2 B2M
24 alcohol dependence 9.9
25 leprosy 3 9.9
26 lyme disease 9.9
27 diabetic polyneuropathy 9.9
28 alcohol use disorder 9.9
29 motor neuron disease 9.9
30 vasculitis 9.9
31 hansen's disease 9.9
32 syphilis 9.8 CD40LG B2M
33 solitary osseous plasmacytoma 9.8 MYOM2 B2M
34 tarsal tunnel syndrome 9.8 TTR B2M
35 tibial neuropathy 9.8 TTR B2M
36 median rhomboid glossitis 9.8 TTR B2M
37 hereditary amyloidosis 9.8 TTR B2M
38 meningoencephalitis 9.8 CD40LG B2M
39 amyloidosis aa 9.8 TTR B2M
40 nerve compression syndrome 9.7 TTR B2M
41 waldenstroem's macroglobulinemia 9.7 MYOM2 MAG B2M
42 mature b-cell neoplasm 9.7 MYOM2 MAG B2M
43 autoimmune disease 9.7
44 charcot-marie-tooth disease, demyelinating, type 1b 9.7
45 neuropathy, hereditary, with liability to pressure palsies 9.7
46 sarcoidosis 1 9.7
47 spondylosis, cervical 9.7
48 celiac disease 1 9.7
49 dandy-walker syndrome 9.7
50 hydrops, lactic acidosis, and sideroblastic anemia 9.7

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy
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Symptoms & Phenotypes for Chronic Polyneuropathy

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MGI Mouse Phenotypes related to Chronic Polyneuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.87 B2M CD40LG CST3 FCGR2B NF1 NUMB
2 cellular MP:0005384 9.86 B2M CD40LG EEF1A2 FCGR2B NF1 NUMB
3 homeostasis/metabolism MP:0005376 9.85 B2M CD40LG CST3 FCGR2B MAG NF1
4 nervous system MP:0003631 9.65 B2M CD40LG CST3 EEF1A2 FCGR2B MAG
5 reproductive system MP:0005389 9.17 B2M CD40LG CST3 NUMB PHYH PMP22
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Drugs & Therapeutics for Chronic Polyneuropathy

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Drugs for Chronic Polyneuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 3 174722-31-7 10201696
2 Immunologic Factors Phase 3
3 Antineoplastic Agents, Immunological Phase 3
4 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Double-blind Randomized Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy Completed NCT00259974 Phase 3 Rituximab
2 A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Efficacy and Safety of Three Doses of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Completed NCT00229437 Phase 2 TAK-128;TAK-128;TAK-128;Placebo
3 An Open-Label, Multi-Center Study to Evaluate the Safety of Long-Term Administration of TAK-128 in Subjects With Mild to Moderate Diabetic Peripheral Neuropathy Terminated NCT00756041 Phase 2 TAK-128

Search NIH Clinical Center for Chronic Polyneuropathy

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Genetic Tests for Chronic Polyneuropathy

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Anatomical Context for Chronic Polyneuropathy

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MalaCards organs/tissues related to Chronic Polyneuropathy:

41
Skin, Liver, Lung, Bone, Bone Marrow, Thyroid, Cerebellum
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Publications for Chronic Polyneuropathy

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Articles related to Chronic Polyneuropathy:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Causes of chronic neuropathies: a single-center experience. 38
31001716 2019
2
Diagnostic value of symptoms in chronic polyneuropathy: The Erasmus Polyneuropathy Symptom Score. 38
31172622 2019
3
Statins do not increase risk of polyneuropathy: A case-control study and literature review. 38
30737334 2019
4
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 38
30739577 2019
5
CSF cystatin C and diffusion tensor imaging parameters as biomarkers of upper motor neuron degeneration in amyotrophic lateral sclerosis. 38
30016754 2018
6
Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. 38
29687564 2018
7
Polyneuropathy relates to impairment in daily activities, worse gait, and fall-related injuries. 38
28566544 2017
8
Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up. 38
28238650 2017
9
Prevalence of polyneuropathy in the general middle-aged and elderly population. 38
27683845 2016
10
The epidemiology and risk factors of chronic polyneuropathy. 38
26700499 2016
11
Peripheral neuropathies. 38
27637963 2016
12
Phytol in a pharma-medico-stance. 38
26296761 2015
13
[Hypomyelination with atrophy of the basal ganglia and cerebellum. Contribution of two new cases to a recently reported entity]. 38
24504878 2014
14
Infectious neuropathies. 38
23945279 2013
15
A serine synthesis defect presenting with a Charcot-Marie-Tooth-like polyneuropathy. 38
22393170 2012
16
Recurrent demyelination and remyelination in 37 young Bengal cats with polyneuropathy. 38
21689154 2011
17
Refsum's Disease-Use of the Intestinal Lipase Inhibitor, Orlistat, as a Novel Therapeutic Approach to a Complex Disorder. 38
20871815 2011
18
[Chronic demyelinating polyneuropathy and B6 hypervitaminosis]. 38
20627481 2010
19
Adult Refsum disease: a form of tapetoretinal dystrophy accessible to therapy. 38
20850855 2010
20
[Charcot-Marie-Tooth (CMT) disease: an update]. 38
20929675 2010
21
Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy. 38
20424898 2010
22
Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. 38
19261857 2009
23
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. 38
18691815 2008
24
Cochlear implantation in Refsum's disease. 38
18698664 2008
25
Infectious neuropathy. 38
17885443 2007
26
[Chronic polyneuropathy--evaluation and diagnosis]. 38
17279107 2007
27
Chronic polyneuropathy and Lyme disease. 38
17038034 2006
28
[Bilateral papilloedema as the initial symptom of POEMS syndrome]. 38
17072808 2006
29
Pain affects the quality of life of neuropathic patients. 38
16897626 2006
30
[Churg-Strauss syndrome complicated by polyneuropathy]. 38
16784146 2006
31
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. 38
16484653 2006
32
[Removal of a tracheostomy in ventilator-dependent patients with neuromuscular disease]. 38
16272975 2005
33
[Adult Refsum disease. A retinal dystrophy with therapeutic options]. 38
15990985 2005
34
Delayed motor and sensory neuropathy in a patient with brainstem encephalitis. 38
15936038 2005
35
Q fever as a cause of pure sensory polyneuropathy -- the six-year itch: a follow-up of an indigenous Swedish case. 38
16308243 2005
36
A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes. 38
15205993 2004
37
Neurofibromatosis 1-associated neuropathies: a reappraisal. 38
15289270 2004
38
[Chronic and predominantly sensory polyneuropathy in Toroku Valley where a mining company produced arsenic]. 38
12607976 2002
39
[Hereditary neuropathy with liability to pressure palsies: study of six Spanish families]. 38
12072826 2002
40
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. 38
12030409 2002
41
Diagnostic yield by testing small fiber function in patients examined for polyneuropathy. 38
11800044 2001
42
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. 38
19078654 2001
43
Prospective follow-up study of chronic polyneuropathy of undetermined cause. 38
11494273 2001
44
Guillain-Barré syndrome following herpes zoster in a patient with systemic sclerosis. 38
24383736 2001
45
Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline. 38
11459893 2001
46
Diabetic neuropathies. 38
11345009 2001
47
[Clinical and paraclinical investigations of chronic polyneuropathies]. 38
10853550 2000
48
Quality of life in patients with axonal polyneuropathy. 38
10787114 2000
49
[Chronic hereditary ataxic polyneuropathy]. 38
11050807 2000
50
Relationship between ischemia and neuropathy. 38
10894988 2000
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Variations for Chronic Polyneuropathy

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Expression for Chronic Polyneuropathy

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Search GEO for disease gene expression data for Chronic Polyneuropathy.
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Pathways for Chronic Polyneuropathy

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Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.46 NUMB NF1 MAG CST3
2
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.26 FCGR2B CD40LG B2M
3
FOXA2 and FOXA3 transcription factor networks 1
10.8 TTR NF1
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GO Terms for Chronic Polyneuropathy

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Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 compact myelin GO:0043218 8.62 PMP22 MAG

Biological processes related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.43 FCGR2B CD40LG B2M
2 cellular protein metabolic process GO:0044267 9.33 TTR CST3 B2M
3 peripheral nervous system development GO:0007422 8.96 PMP22 NF1
4 negative regulation of neuron projection development GO:0010977 8.8 PMP22 MAG B2M

Molecular functions related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 TTR TTK PMP22 PHYH NUMB NF1
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Sources for Chronic Polyneuropathy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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