MCID: CHR094
MIFTS: 24

Chronic Polyneuropathy

Categories: Neuronal diseases

Aliases & Classifications for Chronic Polyneuropathy

MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5221
NCIt 50 C36071
UMLS 71 C1167650

Summaries for Chronic Polyneuropathy

MalaCards based summary : Chronic Polyneuropathy is related to demyelinating polyneuropathy and osteosclerotic myeloma. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways is Peroxisome. Affiliated tissues include bone marrow, cerebellum and b cells, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Chronic Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 demyelinating polyneuropathy 29.9 MAG FCGR2B
2 osteosclerotic myeloma 29.8 MYOM2 MAG
3 mononeuritis multiplex 29.8 MYOM2 MAG
4 monoclonal gammopathy of uncertain significance 29.6 MYOM2 MAG
5 giant axonal neuropathy 1, autosomal recessive 11.0
6 polyneuropathy 10.6
7 autoimmune neuropathy 10.2 MAG FCGR2B
8 rhizomelic chondrodysplasia punctata, type 3 10.1 PHYH PEX7
9 rhizomelic chondrodysplasia punctata 10.1 PHYH PEX7
10 rhizomelic chondrodysplasia punctata, type 2 10.1 PHYH PEX7
11 rhizomelic chondrodysplasia punctata, type 1 10.1 PHYH PEX7
12 chondrodysplasia punctata syndrome 10.1 PHYH PEX7
13 mononeuritis of upper limb and mononeuritis multiplex 10.1 MYOM2 MAG
14 peroxisomal biogenesis disorder 10.1 PHYH PEX7
15 peripheral nervous system disease 10.1
16 neuropathy 10.1
17 plasma protein metabolism disease 10.0 MYOM2 MAG
18 dowling-degos disease 1 10.0
19 chronic inflammatory demyelinating polyradiculoneuropathy 10.0
20 waldenstroem's macroglobulinemia 10.0 MYOM2 MAG
21 blood protein disease 10.0 MYOM2 MAG
22 peroxisomal disease 10.0 PHYH PEX7
23 spinocerebellar ataxia, autosomal recessive 8 9.9 SIL1 SACS
24 vitamin e, familial isolated deficiency of 9.9 TTPA SIL1
25 spastic ataxia, charlevoix-saguenay type 9.9 TTPA SACS
26 leprosy 3 9.9
27 lyme disease 9.9
28 alcohol use disorder 9.9
29 polyradiculoneuropathy 9.9
30 hansen's disease 9.9
31 spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2 9.9 TTPA SACS
32 refsum disease, classic 9.8 TTPA PHYH PEX7
33 peroxisome biogenesis disorder 1b 9.8 PHYH PEX7
34 sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 9.8 SIL1 MYOM2
35 alcohol dependence 9.8
36 autoimmune disease 9.8
37 charcot-marie-tooth disease, demyelinating, type 1b 9.8
38 neuropathy, hereditary, with liability to pressure palsies 9.8
39 spondylosis, cervical 9.8
40 dandy-walker syndrome 9.8
41 neuronal intranuclear inclusion disease 9.8
42 acrodermatitis chronica atrophicans 9.8
43 hypogonadotropic hypogonadism 9.8
44 diabetic polyneuropathy 9.8
45 viral hepatitis 9.8
46 hypogonadism 9.8
47 transient cerebral ischemia 9.8
48 spondylosis 9.8
49 motor neuron disease 9.8
50 sensory peripheral neuropathy 9.8

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy

Symptoms & Phenotypes for Chronic Polyneuropathy

MGI Mouse Phenotypes related to Chronic Polyneuropathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 DHTKD1 FCGR2B MAG PEX7 PHYH SIL1
2 nervous system MP:0003631 9.17 DHTKD1 FCGR2B MAG PEX7 PHYH SIL1

Drugs & Therapeutics for Chronic Polyneuropathy

Search Clinical Trials , NIH Clinical Center for Chronic Polyneuropathy

Genetic Tests for Chronic Polyneuropathy

Anatomical Context for Chronic Polyneuropathy

MalaCards organs/tissues related to Chronic Polyneuropathy:

40
Bone Marrow, Cerebellum, B Cells

Publications for Chronic Polyneuropathy

Articles related to Chronic Polyneuropathy:

(show top 50) (show all 122)
# Title Authors PMID Year
1
Elevated levels of NLRP3 inflammasome in serum of patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated with disease severity. 61
33409826 2021
2
Neuronal intranuclear inclusion disease presenting with an MELAS-like episode in chronic polyneuropathy. 61
33324757 2020
3
Chronic axonal idiopathic polyneuropathy: is it really benign. 61
32773448 2020
4
Screening for Fabry disease in unknown origin axonal polyneuropathy: to do or not to do, this is the question! 61
32819406 2020
5
Thrombosis revealing POEMS syndrome. About a case. 61
32162605 2020
6
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 61
30739577 2020
7
Diagnostic value of symptoms in chronic polyneuropathy: The Erasmus Polyneuropathy Symptom Score. 61
31172622 2019
8
Causes of chronic neuropathies: a single-center experience. 61
31001716 2019
9
Statins do not increase risk of polyneuropathy: A case-control study and literature review. 61
30737334 2019
10
CSF cystatin C and diffusion tensor imaging parameters as biomarkers of upper motor neuron degeneration in amyotrophic lateral sclerosis. 61
30016754 2018
11
Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. 61
29687564 2018
12
Polyneuropathy relates to impairment in daily activities, worse gait, and fall-related injuries. 61
28566544 2017
13
Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up. 61
28238650 2017
14
Prevalence of polyneuropathy in the general middle-aged and elderly population. 61
27683845 2016
15
The epidemiology and risk factors of chronic polyneuropathy. 61
26700499 2016
16
Peripheral neuropathies. 61
27637963 2016
17
Phytol in a pharma-medico-stance. 61
26296761 2015
18
[Hypomyelination with atrophy of the basal ganglia and cerebellum. Contribution of two new cases to a recently reported entity]. 61
24504878 2014
19
Infectious neuropathies. 61
23945279 2013
20
A serine synthesis defect presenting with a Charcot-Marie-Tooth-like polyneuropathy. 61
22393170 2012
21
Recurrent demyelination and remyelination in 37 young Bengal cats with polyneuropathy. 61
21689154 2011
22
Refsum's Disease-Use of the Intestinal Lipase Inhibitor, Orlistat, as a Novel Therapeutic Approach to a Complex Disorder. 61
20871815 2011
23
[Chronic demyelinating polyneuropathy and B6 hypervitaminosis]. 61
20627481 2010
24
Adult Refsum disease: a form of tapetoretinal dystrophy accessible to therapy. 61
20850855 2010
25
[Charcot-Marie-Tooth (CMT) disease: an update]. 61
20929675 2010
26
Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy. 61
20424898 2010
27
Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. 61
19261857 2009
28
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. 61
18691815 2008
29
Cochlear implantation in Refsum's disease. 61
18698664 2008
30
Infectious neuropathy. 61
17885443 2007
31
[Chronic polyneuropathy--evaluation and diagnosis]. 61
17279107 2007
32
Chronic polyneuropathy and Lyme disease. 61
17038034 2006
33
[Bilateral papilloedema as the initial symptom of POEMS syndrome]. 61
17072808 2006
34
Pain affects the quality of life of neuropathic patients. 61
16897626 2006
35
[Churg-Strauss syndrome complicated by polyneuropathy]. 61
16784146 2006
36
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. 61
16484653 2006
37
[Removal of a tracheostomy in ventilator-dependent patients with neuromuscular disease]. 61
16272975 2005
38
[Adult Refsum disease. A retinal dystrophy with therapeutic options]. 61
15990985 2005
39
Delayed motor and sensory neuropathy in a patient with brainstem encephalitis. 61
15936038 2005
40
Q fever as a cause of pure sensory polyneuropathy -- the six-year itch: a follow-up of an indigenous Swedish case. 61
16308243 2005
41
A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes. 61
15205993 2004
42
Neurofibromatosis 1-associated neuropathies: a reappraisal. 61
15289270 2004
43
[Chronic and predominantly sensory polyneuropathy in Toroku Valley where a mining company produced arsenic]. 61
12607976 2002
44
[Hereditary neuropathy with liability to pressure palsies: study of six Spanish families]. 61
12072826 2002
45
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. 61
12030409 2002
46
Diagnostic yield by testing small fiber function in patients examined for polyneuropathy. 61
11800044 2001
47
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. 61
19078654 2001
48
Prospective follow-up study of chronic polyneuropathy of undetermined cause. 61
11494273 2001
49
Guillain-Barré syndrome following herpes zoster in a patient with systemic sclerosis. 61
24383736 2001
50
Diagnostic investigation of patients with chronic polyneuropathy: evaluation of a clinical guideline. 61
11459893 2001

Variations for Chronic Polyneuropathy

Expression for Chronic Polyneuropathy

Search GEO for disease gene expression data for Chronic Polyneuropathy.

Pathways for Chronic Polyneuropathy

Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 PHYH PEX7

GO Terms for Chronic Polyneuropathy

Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxisomal matrix GO:0005782 8.62 PHYH PEX7

Biological processes related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein targeting to peroxisome GO:0006625 8.62 PHYH PEX7

Sources for Chronic Polyneuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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