MCID: CHR094
MIFTS: 23

Chronic Polyneuropathy

Categories: Neuronal diseases
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Aliases & Classifications for Chronic Polyneuropathy

MalaCards integrated aliases for Chronic Polyneuropathy:

Name: Chronic Polyneuropathy 11 14 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5221
NCIt 49 C36071
UMLS 71 C1167650

Summaries for Chronic Polyneuropathy

MalaCards based summary: Chronic Polyneuropathy is related to polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy. An important gene associated with Chronic Polyneuropathy is MAG (Myelin Associated Glycoprotein), and among its related pathways/superpathways is EGR2 and SOX10-mediated initiation of Schwann cell myelination. Affiliated tissues include bone marrow, b cells and cerebellum.

Related Diseases for Chronic Polyneuropathy

Diseases in the Polyneuropathy family:

Polyneuropathy Due to Drug Chronic Polyneuropathy

Diseases related to Chronic Polyneuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 polyneuropathy 30.5 SLC25A19 PMP22 MAG
2 chronic inflammatory demyelinating polyradiculoneuropathy 30.2 PMP22 MAG
3 demyelinating polyneuropathy 30.0 PMP22 MAG
4 hereditary neuropathies 29.9 PMP22 MAG
5 neuropathy, hereditary, with liability to pressure palsies 29.8 PMP22 MAG
6 sensory peripheral neuropathy 29.4 PMP22 MAG
7 giant axonal neuropathy 1, autosomal recessive 11.0
8 asymmetric motor neuropathy 10.2 PMP22 MAG
9 plexopathy 10.2 PMP22 MAG
10 mononeuritis of upper limb and mononeuritis multiplex 10.1 PMP22 MAG
11 neuritis 10.1 PMP22 MAG
12 mononeuropathy 10.1 PMP22 MAG
13 charcot-marie-tooth disease, demyelinating, type 1a 10.1 PMP22 MAG
14 alcohol use disorder 10.1
15 peripheral nervous system disease 10.1
16 neuropathy 10.1
17 rhizomelic chondrodysplasia punctata, type 1 10.0 PHYH HADHB
18 motor peripheral neuropathy 10.0 PMP22 MAG
19 rhizomelic chondrodysplasia punctata 10.0 PHYH HADHB
20 pelizaeus-merzbacher disease 10.0 PMP22 MAG
21 peroxisomal disease 10.0 PHYH HADHB
22 hypertrophic neuropathy of dejerine-sottas 9.9 PMP22 MAG
23 adie pupil 9.9
24 alcohol dependence 9.9
25 guillain-barre syndrome, familial 9.9
26 leprosy 3 9.9
27 myeloma, multiple 9.9
28 sjogren syndrome 9.9
29 lyme disease 9.9
30 polyradiculoneuropathy 9.9
31 amyotrophic lateral sclerosis 1 9.8
32 charcot-marie-tooth disease, demyelinating, type 1b 9.8
33 hypogonadotropic hypogonadism 7 with or without anosmia 9.8
34 spondylosis, cervical 9.8
35 dandy-walker syndrome 9.8
36 refsum disease, classic 9.8
37 inflammatory bowel disease 1 9.8
38 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 9.8
39 neuronal intranuclear inclusion disease 9.8
40 microvascular complications of diabetes 1 9.8
41 acrodermatitis chronica atrophicans 9.8
42 hypogonadotropic hypogonadism 9.8
43 diabetic polyneuropathy 9.8
44 poems syndrome 9.8
45 mononeuritis multiplex 9.8
46 viral hepatitis 9.8
47 hypogonadism 9.8
48 transient cerebral ischemia 9.8
49 spondylosis 9.8
50 motor neuron disease 9.8

Graphical network of the top 20 diseases related to Chronic Polyneuropathy:



Diseases related to Chronic Polyneuropathy

Symptoms & Phenotypes for Chronic Polyneuropathy

Drugs & Therapeutics for Chronic Polyneuropathy

Search Clinical Trials, NIH Clinical Center for Chronic Polyneuropathy

Genetic Tests for Chronic Polyneuropathy

Anatomical Context for Chronic Polyneuropathy

Organs/tissues related to Chronic Polyneuropathy:

MalaCards : Bone Marrow, B Cells, Cerebellum, Skin, Liver, Bone

Publications for Chronic Polyneuropathy

Articles related to Chronic Polyneuropathy:

(show top 50) (show all 126)
# Title Authors PMID Year
1
Controversies in neuroimmunology: multiple sclerosis, vaccination, SARS-CoV-2 and other dilemas 62
36322548 2022
2
Clinical and genetic studies of thiamine metabolism dysfunction syndrome-4: case series and review of the literature. 62
35102031 2022
3
Elevated levels of NLRP3 inflammasome in serum of patients with chronic inflammatory demyelinating polyradiculoneuropathy are associated with disease severity. 62
33409826 2021
4
Mitochondrial trifunctional protein deficiency as a polyneuropathy etiology in childhood. 62
35023662 2021
5
Genome-Wide Association Study of 2,093 Cases With Idiopathic Polyneuropathy and 445,256 Controls Identifies First Susceptibility Loci. 62
34975738 2021
6
Neuronal intranuclear inclusion disease presenting with an MELAS-like episode in chronic polyneuropathy. 62
33324757 2020
7
Chronic axonal idiopathic polyneuropathy: is it really benign. 62
32773448 2020
8
Screening for Fabry disease in unknown origin axonal polyneuropathy: to do or not to do, this is the question! 62
32819406 2020
9
Thrombosis revealing POEMS syndrome. About a case. 62
32162605 2020
10
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 62
30739577 2020
11
Diagnostic value of symptoms in chronic polyneuropathy: The Erasmus Polyneuropathy Symptom Score. 62
31172622 2019
12
Causes of chronic neuropathies: a single-center experience. 62
31001716 2019
13
Statins do not increase risk of polyneuropathy: A case-control study and literature review. 62
30737334 2019
14
CSF cystatin C and diffusion tensor imaging parameters as biomarkers of upper motor neuron degeneration in amyotrophic lateral sclerosis. 62
30016754 2018
15
Clinical spectrum and quality of life in patients with chronic polyneuropathy: A cross-sectional study. 62
29687564 2018
16
Polyneuropathy relates to impairment in daily activities, worse gait, and fall-related injuries. 62
28566544 2017
17
Which patients discontinue? Issues on Levodopa/carbidopa intestinal gel treatment: Italian multicentre survey of 905 patients with long-term follow-up. 62
28238650 2017
18
Prevalence of polyneuropathy in the general middle-aged and elderly population. 62
27683845 2016
19
The epidemiology and risk factors of chronic polyneuropathy. 62
26700499 2016
20
Peripheral neuropathies. 62
27637963 2016
21
Phytol in a pharma-medico-stance. 62
26296761 2015
22
[Hypomyelination with atrophy of the basal ganglia and cerebellum. Contribution of two new cases to a recently reported entity]. 62
24504878 2014
23
Infectious neuropathies. 62
23945279 2013
24
A serine synthesis defect presenting with a Charcot-Marie-Tooth-like polyneuropathy. 62
22393170 2012
25
Recurrent demyelination and remyelination in 37 young Bengal cats with polyneuropathy. 62
21689154 2011
26
Refsum's Disease-Use of the Intestinal Lipase Inhibitor, Orlistat, as a Novel Therapeutic Approach to a Complex Disorder. 62
20871815 2011
27
[Chronic demyelinating polyneuropathy and B6 hypervitaminosis]. 62
20627481 2010
28
Adult Refsum disease: a form of tapetoretinal dystrophy accessible to therapy. 62
20850855 2010
29
[Charcot-Marie-Tooth (CMT) disease: an update]. 62
20929675 2010
30
Mechanisms of IVIG efficacy in chronic inflammatory demyelinating polyneuropathy. 62
20424898 2010
31
Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. 62
19261857 2009
32
A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy. 62
18691815 2008
33
Cochlear implantation in Refsum's disease. 62
18698664 2008
34
Infectious neuropathy. 62
17885443 2007
35
[Chronic polyneuropathy--evaluation and diagnosis]. 62
17279107 2007
36
Chronic polyneuropathy and Lyme disease. 62
17038034 2006
37
[Bilateral papilloedema as the initial symptom of POEMS syndrome]. 62
17072808 2006
38
Pain affects the quality of life of neuropathic patients. 62
16897626 2006
39
[Churg-Strauss syndrome complicated by polyneuropathy]. 62
16784146 2006
40
Feasibility and cost efficiency of a diagnostic guideline for chronic polyneuropathy: a prospective implementation study. 62
16484653 2006
41
[Removal of a tracheostomy in ventilator-dependent patients with neuromuscular disease]. 62
16272975 2005
42
[Adult Refsum disease. A retinal dystrophy with therapeutic options]. 62
15990985 2005
43
Delayed motor and sensory neuropathy in a patient with brainstem encephalitis. 62
15936038 2005
44
Q fever as a cause of pure sensory polyneuropathy -- the six-year itch: a follow-up of an indigenous Swedish case. 62
16308243 2005
45
A novel PMP22 mutation Ser22Phe in a family with hereditary neuropathy with liability to pressure palsies and CMT1A phenotypes. 62
15205993 2004
46
Neurofibromatosis 1-associated neuropathies: a reappraisal. 62
15289270 2004
47
[Chronic and predominantly sensory polyneuropathy in Toroku Valley where a mining company produced arsenic]. 62
12607976 2002
48
[Hereditary neuropathy with liability to pressure palsies: study of six Spanish families]. 62
12072826 2002
49
Chronic demyelinating polyneuropathy in graft-versus-host disease following allogeneic bone marrow transplantation. 62
12030409 2002
50
Evaluation of patients with symptoms suggestive of chronic polyneuropathy. 62
19078654 2001

Variations for Chronic Polyneuropathy

Expression for Chronic Polyneuropathy

Search GEO for disease gene expression data for Chronic Polyneuropathy.

Pathways for Chronic Polyneuropathy

Pathways related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 PMP22 MAG

GO Terms for Chronic Polyneuropathy

Cellular components related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 compact myelin GO:0043218 8.92 PMP22 MAG

Molecular functions related to Chronic Polyneuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 catalytic activity GO:0003824 8.8 PHYH PGAM2 AASS

Sources for Chronic Polyneuropathy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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