Chronic Pulmonary Heart Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR096 MIFTS: 36	Chronic Pulmonary Heart Disease Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Chronic Pulmonary Heart Disease

MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12326

ICD9CM ³⁵ 416.8

UMLS ⁷³ C0155673 C0238074

Sources

Summaries for Chronic Pulmonary Heart Disease

MalaCards based summary : Chronic Pulmonary Heart Disease is related to heart disease and pulmonary hypertension. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and DREAM Repression and Dynorphin Expression. The drugs Iron and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Chronic Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)

#	Related Disease	Score	Top Affiliating Genes
1	heart disease	30.7	BMPR2 EDN1 HP TNF
2	pulmonary hypertension	28.6	ACVRL1 BMPR2 EDN1 HTR2B PTGIR SLC6A4
3	nutmeg liver	10.2	CP HP
4	chronic inflammatory demyelinating polyneuropathy	10.2	HP TTR
5	burns	10.2	TNF TTR
6	chronic thromboembolic pulmonary hypertension	10.2	BMPR2 EDN1
7	melancholia	10.2	HP TNF
8	meconium aspiration syndrome	10.2	EDN1 TNF
9	glossitis	10.2	TNF TTR
10	endometrial disease	10.2	HP TNF
11	granulocytopenia	10.1	CP TNF
12	nontuberculous mycobacterial lung disease	10.1	ADIPOQ TNF
13	raynaud disease	10.1	EDN1 PTGIR
14	eisenmenger syndrome	10.1	BMPR2 EDN1
15	spondylarthropathy	10.1	HP TNF
16	nonalcoholic steatohepatitis	10.1	ADIPOQ TNF
17	idiopathic edema	10.1	ADIPOQ EDN1
18	corticosteroid-binding globulin deficiency	10.1	CP HP
19	eales disease	10.1	CP TNF
20	obstructive jaundice	10.1	EDN1 TNF TTR
21	pulmonary venoocclusive disease	10.1	ACVRL1 BMPR2
22	microscopic colitis	10.1	SLC6A4 TNF
23	apnea, obstructive sleep	10.1	ADIPOQ EDN1 TNF
24	endometritis	10.1	HP TNF
25	sleep apnea	10.1	ADIPOQ EDN1 TNF
26	portal hypertension	10.1	BMPR2 EDN1 TNF
27	chronic kidney failure	10.1	ADIPOQ EDN1 TTR
28	acquired metabolic disease	10.0	ADIPOQ TNF TTR
29	liver cirrhosis	10.0	ADIPOQ EDN1 TTR
30	mixed connective tissue disease	10.0	ACVRL1 BMPR2 TNF
31	protein-energy malnutrition	10.0	CP HP TNF TTR
32	central nervous system disease	10.0	SLC6A4 TNF TTR
33	anorexia nervosa	10.0	ADIPOQ SLC6A4 TTR
34	telangiectasis	10.0	ACVRL1 BMPR2
35	sexual disorder	10.0	EDN1 SLC6A4
36	dysentery	9.9	HP TTR
37	hepatopulmonary syndrome	9.9	ACVRL1 BMPR2 EDN1 TNF
38	connective tissue disease	9.9	ACVRL1 BMPR2 EDN1 TNF
39	migraine with or without aura 1	9.9	HTR2B SLC6A4 TNF
40	pulmonary hypertension, primary, 1	9.8	ACVRL1 BMPR2 EDN1 SLC6A4
41	heritable pulmonary arterial hypertension	9.8	ACVRL1 BMPR2 SMAD9
42	arteries, anomalies of	9.8	ACVRL1 ADIPOQ BMPR2 EDN1 TNF
43	vascular disease	9.6	ACVRL1 ADIPOQ BMPR2 EDN1 HP TNF

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 35)

Acquired Polycythemia	Active Peptic Ulcer Disease
Acute Cor Pulmonale	Acute Cystitis
Anthracosis	Anxiety
Asbestosis	Bronchiectasis
Bronchitis	Bronchopneumonia
Chronic Myocardial Ischemia	Conn's Syndrome
Deficiency Anemia	Dysthymic Disorder
Esophagitis	Familial Atrial Fibrillation
Heart Disease	Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism	Idiopathic Interstitial Pneumonia
Ischemic Heart Disease	Mitral Valve Disease
Oral Candidiasis	Osteoporosis
Peripheral Vascular Disease	Postinflammatory Pulmonary Fibrosis
Primary Polycythemia	Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1	Respiratory Failure
Right Bundle Branch Block	Sleep Apnea
Status Asthmaticus	Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:

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Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

²⁶ (show all 17)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased shRNA abundance (Z-score > 2)	GR00366-A-115	9.6	HTR2B
2	Increased shRNA abundance (Z-score > 2)	GR00366-A-122	9.6	SLC6A4
3	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	9.6	HTR2B
4	Increased shRNA abundance (Z-score > 2)	GR00366-A-159	9.6	EDN1
5	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	9.6	HTR2B
6	Increased shRNA abundance (Z-score > 2)	GR00366-A-194	9.6	HTR2B
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-198	9.6	SLC6A4
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-2	9.6	EDN1
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	9.6	HTR2B
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-23	9.6	SLC6A4
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-25	9.6	EDN1
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.6	EDN1
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-47	9.6	HTR2B
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.6	EDN1 HTR2B SLC6A4
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-88	9.6	EDN1
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.6	HTR2B
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-90	9.6	SLC6A4

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.23	ACVRL1 ADIPOQ BMPR2 CP EDN1 HP
2	behavior/neurological	MP:0005386	10.08	ACVRL1 ADIPOQ BMPR2 CP PTGIR SLC6A4
3	homeostasis/metabolism	MP:0005376	10.07	ACVRL1 ADIPOQ BMPR2 CP EDN1 HP
4	mortality/aging	MP:0010768	10.02	ACVRL1 ADIPOQ BMPR2 EDN1 HP HTR2B
5	growth/size/body region	MP:0005378	10.01	ACVRL1 ADIPOQ BMPR2 EDN1 HTR2B SLC6A4
6	embryo	MP:0005380	9.91	ACVRL1 BMPR2 EDN1 HTR2B SMAD9 TNF
7	muscle	MP:0005369	9.86	ACVRL1 ADIPOQ BMPR2 EDN1 HTR2B SLC6A4
8	nervous system	MP:0003631	9.56	ACVRL1 ADIPOQ BMPR2 CP EDN1 SLC6A4
9	neoplasm	MP:0002006	9.55	ADIPOQ HP PTGIR SMAD9 TNF
10	renal/urinary system	MP:0005367	9.1	ACVRL1 ADIPOQ BMPR2 EDN1 HP TTR

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Drugs & Therapeutics for Chronic Pulmonary Heart Disease

Drugs for Chronic Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Iron

Approved

Phase 4

7439-89-6

23925

Lactitol

Investigational

Phase 4

585-86-4

3871

Ferric Compounds

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Hematinics

Phase 4

Pharmaceutical Solutions

Phase 4

Metoprolol

Approved, Investigational

Phase 3

37350-58-6, 51384-51-1

4171

Neurotransmitter Agents

Phase 3,Not Applicable

Adrenergic Agents

Phase 3,Not Applicable

Autonomic Agents

Phase 3,Not Applicable

Antihypertensive Agents

Phase 3,Not Applicable

Peripheral Nervous System Agents

Phase 3,Not Applicable

Anti-Arrhythmia Agents

Phase 3

Adrenergic beta-Antagonists

Phase 3

Adrenergic beta-1 Receptor Antagonists

Phase 3

Sympatholytics

Phase 3

Adrenergic Antagonists

Phase 3

Immunologic Factors

Phase 1

Vaccines

Phase 1

tannic acid

Approved

Not Applicable

Benzocaine

Approved, Investigational

Not Applicable

94-09-7, 1994-09-7

2337

Zinc

Approved, Investigational

Not Applicable

7440-66-6

Exenatide

Approved, Investigational

Not Applicable

141758-74-9

15991534

Dobutamine

Approved

Not Applicable

34368-04-2

36811

Amlodipine

Approved

Not Applicable

88150-42-9

2162

Cabergoline

Approved

81409-90-7

54746

Dopamine

Approved

51-61-6, 62-31-7

681

Levodopa

Approved

59-92-7

6047

Hormone Antagonists

Not Applicable

Hormones, Hormone Substitutes, and Hormone Antagonists

Not Applicable

Incretins

Not Applicable

Hypoglycemic Agents

Not Applicable

Glucagon-Like Peptide 1

Not Applicable

Hormones

Not Applicable

Sympathomimetics

Not Applicable

Adrenergic beta-Agonists

Not Applicable

Adrenergic Agonists

Not Applicable

Calcium, Dietary

Not Applicable

Cardiotonic Agents

Not Applicable

Protective Agents

Not Applicable

calcium channel blockers

Not Applicable

Vasodilator Agents

Not Applicable

Dopamine Agents

Dopamine agonists

Vasoconstrictor Agents

Interventional clinical trials:

(show all 25)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients	Unknown status	NCT02416778	Phase 4	Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
2	Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients	Completed	NCT01996124	Phase 4	Indacaterol Fumarate;Placebo
3	Integrated Care Program for Chronic Obstructive Pulmonary Disease	Completed	NCT01045213	Phase 3
4	Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease	Recruiting	NCT02587351	Phase 3	Metoprolol succinate
5	Autologous Bronchial Basal Cell Transplantation for Treatment of COPD	Recruiting	NCT03188627	Phase 1, Phase 2
6	Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD)	Recruiting	NCT03092648	Phase 1, Phase 2
7	Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO	Completed	NCT02027129	Phase 1
8	A Phase I Randomized, Observer-Blinded, Dose-Ranging Study in Healthy Subjects 24 to <72 Months of Age	Completed	NCT02296463	Phase 1
9	Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD	Not yet recruiting	NCT03655795	Phase 1
10	Metabolic Changes in Patients With Chronic Cardiopulmonary Disease	Unknown status	NCT02550808
11	Effect of Normatec Pump for Relief of Leg Edema in Patients With Right Heart Failure	Unknown status	NCT00834145	Not Applicable
12	The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients	Unknown status	NCT02600039	Not Applicable
13	Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)	Unknown status	NCT01757522
14	Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale	Completed	NCT03243994	Not Applicable
15	The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale	Completed	NCT02976324	Not Applicable
16	Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease	Completed	NCT01554774
17	NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE)	Completed	NCT01633671
18	Impact of NaHCO3- on Exercise Hyperpnea	Completed	NCT03057535	Early Phase 1	Sodium Bicarbonate;Sodium Chloride
19	Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS)	Completed	NCT01553227	Not Applicable
20	World Trade Center (WTC) CHEST	Completed	NCT01466218
21	Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome	Completed	NCT01444898	Not Applicable	Exenatide
22	Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF)	Completed	NCT01354613	Not Applicable	Dobutamine;Amlodipine
23	The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events	Completed	NCT01052948
24	An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation	Recruiting	NCT03021681	Not Applicable
25	Study of Renin-angiotensin System in Mechanically Ventilated Subjects	Recruiting	NCT03212690		Local standard of care

Search NIH Clinical Center for Chronic Pulmonary Heart Disease

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Genetic Tests for Chronic Pulmonary Heart Disease

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Anatomical Context for Chronic Pulmonary Heart Disease

MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

⁴¹

Heart, Endothelial, Lung, Kidney, Liver

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Publications for Chronic Pulmonary Heart Disease

Articles related to Chronic Pulmonary Heart Disease:

(show all 25)

#	Title	Authors	Year
1	Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. ( 27629759 )	Liu Y....Su Y.	2016
2	Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. ( 24294047 )	Liu H.F....Wang L.	2013
3	Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. ( 24142714 )	Ke QM...Du YM	2013
4	Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21860655 )	Jian-Sheng L...Ya L	2012
5	Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21711201 )		2011
6	[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. ( 19080646 )	Shi H.F....He H.W.	2008
7	Hospital Stays Involving Chronic Pulmonary Heart Disease, 2005: Statistical Brief #43 ( 21755628 )		2006
8	[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. ( 12934401 )		2003
9	The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. ( 12435299 )	Huang X....Fan X.	2002
10	Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. ( 11263275 )		2000
11	Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment. ( 7774397 )		1995
12	Effects of sustained ligustrazine on hemorrheology in patients with chronic pulmonary heart disease. ( 1453503 )	Peng W...Cui LH	1992
13	Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease. ( 1816412 )	Peng W....Duan S.F.	1991
14	[Noninvasive diagnosis of pulmonary hypertension in aged and elderly patients with chronic pulmonary heart disease]. ( 1857088 )	Korkushko O.V....Vozniuk V.V.	1991
15	Chronic pulmonary heart disease. ( 4557432 )	Thomas A.J.	1972
16	Respiratory acidosis in chronic pulmonary heart disease and the red cell pattern. ( 14025248 )	Daum S....Kopecky M.	1962
17	The blood-gas exchange and the pH in chronic pulmonary heart disease. ( 13883689 )		1962
18	PREDNISOLONE MAINTENANCE THERAPY IN CHRONIC PULMONARY HEART DISEASE. ( 18610137 )	Mickerson J.N.	1960
19	Pharmacological aspects of the pulmonary circulation in chronic pulmonary heart disease. ( 13848401 )	HALMAGYI D.F.	1959
20	The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. ( 13623896 )	MOTLEY H.L.	1959
21	Respiratory acidosis in chronic pulmonary heart disease: pathogenesis, clinical features and management. ( 13623895 )		1959
22	[Chronic pulmonary heart disease]. ( 13231686 )	DOSSOLA A.A.	1954
23	Pneumoperitoneum in chronic pulmonary heart disease. ( 13084926 )	Heilig R....Sharma R.K.	1953
24	Chronic pulmonary heart disease. ( 14935191 )	ORAM S	1952
25	Electrocardiographic appearances in acute and chronic pulmonary heart disease. ( 18880733 )	Wood P.	1948

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Genes for Chronic Pulmonary Heart Disease

Genes related to Chronic Pulmonary Heart Disease (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	EDN1	Endothelin 1	Protein Coding	23.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	18.6	DISEASES inferred ¹⁵
3	CP	Ceruloplasmin	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
4	HP	Haptoglobin	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
5	TTR	Transthyretin	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
6	TNF	Tumor Necrosis Factor	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
7	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	16.78	GeneCards inferred via : Publications (show sections)
8	ACVRL1	Activin A Receptor Like Type 1	Protein Coding	16.43	DISEASES inferred ¹⁵
9	PTGIR	Prostaglandin I2 Receptor	Protein Coding	16.35	DISEASES inferred ¹⁵
10	HTR2B	5-Hydroxytryptamine Receptor 2B	Protein Coding	15.89	DISEASES inferred ¹⁵
11	SMAD9	SMAD Family Member 9	Protein Coding	15.46	DISEASES inferred ¹⁵
12	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	15.37	DISEASES inferred ¹⁵

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Variations for Chronic Pulmonary Heart Disease

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Expression for Chronic Pulmonary Heart Disease

Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.

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Pathways for Chronic Pulmonary Heart Disease

Pathways related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	IL-1 Family Signaling Pathways ⁶⁵ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.88	CP EDN1 TNF
2	DREAM Repression and Dynorphin Expression ⁶⁴ Show member pathways BMP Pathway ⁶⁴ Caspase Cascade ⁶⁴ Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels ⁶⁶ nNOS Signaling in Skeletal Muscle ⁶⁴ TOB in Osteoblast Signaling ⁶⁴	11.72	ACVRL1 BMPR2 SMAD9 TNF
3	Fluid shear stress and atherosclerosis ³⁷	11.64	BMPR2 EDN1 TNF
4	TGF-beta signaling pathway (KEGG) ³⁷	11.26	BMPR2 SMAD9 TNF
5	Endothelin Pathways ¹	11.03	EDN1 PTGIR
6	Prostaglandin Synthesis and Regulation ¹	10.95	EDN1 PTGIR
7	Differentiation of white and brown adipocyte ¹	10.83	ADIPOQ SMAD9
8	Cardiomyocyte Differentiation through BMP Receptors ⁶⁴	10.75	BMPR2 SMAD9
9	Transcription factor regulation in adipogenesis ¹	10.71	ADIPOQ TNF
10	ALK2 signaling events ¹	10.3	BMPR2 SMAD9
11	ALK1 signaling events ¹ Show member pathways ALK1 pathway ¹	10.23	ACVRL1 BMPR2 SMAD9

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GO Terms for Chronic Pulmonary Heart Disease

Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.46	ACVRL1 ADIPOQ BMPR2 TNF
2	integral component of plasma membrane	GO:0005887	9.43	ACVRL1 BMPR2 HTR2B PTGIR SLC6A4 TNF
3	extracellular space	GO:0005615	9.17	ADIPOQ BMPR2 CP EDN1 HP TNF

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 31)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.9	ADIPOQ EDN1 TNF TTR
2	response to drug	GO:0042493	9.84	ADIPOQ EDN1 HTR2B SLC6A4
3	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO:0043123	9.78	ADIPOQ HTR2B TNF
4	transforming growth factor beta receptor signaling pathway	GO:0007179	9.74	ACVRL1 BMPR2 SMAD9
5	response to organic substance	GO:0010033	9.72	HP SLC6A4 TNF
6	BMP signaling pathway	GO:0030509	9.7	ACVRL1 BMPR2 SMAD9
7	negative regulation of endothelial cell proliferation	GO:0001937	9.65	ACVRL1 TNF
8	positive regulation of BMP signaling pathway	GO:0030513	9.65	ACVRL1 BMPR2
9	phosphatidylinositol 3-kinase signaling	GO:0014065	9.64	EDN1 HTR2B
10	blood vessel remodeling	GO:0001974	9.64	ACVRL1 BMPR2
11	blood vessel morphogenesis	GO:0048514	9.63	ACVRL1 EDN1
12	positive regulation of cytokine production	GO:0001819	9.63	HTR2B TNF
13	positive regulation of cytokine secretion	GO:0050715	9.62	HTR2B TNF
14	positive regulation of interleukin-8 production	GO:0032757	9.62	ADIPOQ TNF
15	protein kinase C-activating G protein-coupled receptor signaling pathway	GO:0007205	9.61	EDN1 HTR2B
16	positive regulation of endothelial cell proliferation	GO:0001938	9.61	ACVRL1 BMPR2 HTR2B
17	transmembrane receptor protein serine/threonine kinase signaling pathway	GO:0007178	9.59	ACVRL1 BMPR2
18	activin receptor signaling pathway	GO:0032924	9.58	ACVRL1 BMPR2
19	lymphangiogenesis	GO:0001946	9.58	ACVRL1 BMPR2
20	negative regulation of hormone secretion	GO:0046888	9.56	ADIPOQ EDN1
21	response to hypoxia	GO:0001666	9.56	ACVRL1 ADIPOQ EDN1 SLC6A4
22	positive regulation of MAP kinase activity	GO:0043406	9.54	EDN1 HTR2B TNF
23	artery development	GO:0060840	9.51	ACVRL1 BMPR2
24	endothelial cell apoptotic process	GO:0072577	9.49	BMPR2 TNF
25	negative regulation of platelet-derived growth factor receptor signaling pathway	GO:0010642	9.48	ADIPOQ PTGIR
26	retina vasculature development in camera-type eye	GO:0061298	9.46	ACVRL1 BMPR2
27	lymphatic endothelial cell differentiation	GO:0060836	9.4	ACVRL1 BMPR2
28	cellular response to BMP stimulus	GO:0071773	9.33	ACVRL1 BMPR2 SMAD9
29	venous blood vessel development	GO:0060841	9.32	ACVRL1 BMPR2
30	vasoconstriction	GO:0042310	9.13	EDN1 HTR2B SLC6A4
31	negative regulation of DNA biosynthetic process	GO:2000279	8.8	ACVRL1 ADIPOQ BMPR2

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.54	ADIPOQ EDN1 TNF
2	hormone activity	GO:0005179	9.43	ADIPOQ EDN1 TTR
3	transforming growth factor beta-activated receptor activity	GO:0005024	9.32	ACVRL1 BMPR2
4	transmembrane receptor protein serine/threonine kinase activity	GO:0004675	9.16	ACVRL1 BMPR2
5	serotonin binding	GO:0051378	8.96	HTR2B SLC6A4
6	BMP receptor activity	GO:0098821	8.62	ACVRL1 BMPR2

Sources

Sources for Chronic Pulmonary Heart Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia