MCID: CHR096
MIFTS: 39

Chronic Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Chronic Pulmonary Heart Disease

MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12326
ICD9CM 35 416.8
SNOMED-CT 68 194887007 194889005

Summaries for Chronic Pulmonary Heart Disease

MalaCards based summary : Chronic Pulmonary Heart Disease is related to heart disease and pulmonary hypertension. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are Circadian rythm related genes and IL-1 Family Signaling Pathways. The drugs Iron and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include heart, small intestine and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 heart disease 29.8 ADIPOQ BMPR2 EDN1 TNF
2 pulmonary hypertension 28.5 ACVRL1 BMPR2 EDN1 HTR2B PTGIR SLC6A4
3 nutmeg liver 10.7 CP HP
4 granulocytopenia 10.7 CP TNF
5 chronic inflammatory demyelinating polyneuropathy 10.7 HP TTR
6 melancholia 10.6 HP TNF
7 chronic thromboembolic pulmonary hypertension 10.6 BMPR2 EDN1
8 burns 10.6 TNF TTR
9 meconium aspiration syndrome 10.6 EDN1 TNF
10 epileptic encephalopathy, early infantile, 36 10.5 CP HP
11 eisenmenger syndrome 10.5 BMPR2 EDN1
12 raynaud disease 10.5 EDN1 PTGIR
13 nonalcoholic steatohepatitis 10.5 ADIPOQ TNF
14 idiopathic edema 10.5 ADIPOQ EDN1
15 eales disease 10.5 CP TNF
16 nontuberculous mycobacterial lung disease 10.5 ADIPOQ TNF
17 perinephritis 10.4 EDN1 HTR7
18 coronary artery vasospasm 10.4 EDN1 HTR7
19 corticosteroid-binding globulin deficiency 10.4 CP HP
20 obstructive jaundice 10.3 EDN1 TNF TTR
21 pulmonary hypertension, primary, 1 10.3 ACVRL1 BMPR2
22 apnea, obstructive sleep 10.3 ADIPOQ EDN1 TNF
23 protein-energy malnutrition 10.3 CP TNF TTR
24 endometritis 10.3 HP TNF
25 heritable pulmonary arterial hypertension 10.3 ACVRL1 BMPR2
26 sleep apnea 10.3 ADIPOQ EDN1 TNF
27 portal hypertension 10.3 BMPR2 EDN1 TNF
28 pulmonary venoocclusive disease 10.2 ACVRL1 BMPR2
29 chronic kidney failure 10.2 ADIPOQ EDN1 TTR
30 acquired metabolic disease 10.2 ADIPOQ TNF TTR
31 mixed connective tissue disease 10.0 ACVRL1 BMPR2 TNF
32 microscopic colitis 9.9 SLC6A4 TNF
33 dysentery 9.8 HP TTR
34 telangiectasis 9.8 ACVRL1 BMPR2
35 atypical depressive disorder 9.8 HTR7 SLC6A4
36 psychosexual disorder 9.8 HTR7 SLC6A4
37 dysthymic disorder 9.7 HTR7 SLC6A4
38 arteries, anomalies of 9.7 ACVRL1 ADIPOQ EDN1 TNF
39 kleptomania 9.7 HTR7 SLC6A4
40 aging 9.7
41 endotheliitis 9.7
42 connective tissue disease 9.7 ACVRL1 BMPR2 EDN1 TNF
43 liver disease 9.6 ADIPOQ CP TNF
44 intermittent explosive disorder 9.6 HTR7 SLC6A4
45 anorexia nervosa 9.6 ADIPOQ SLC6A4 TTR
46 brunner syndrome 9.5 HTR7 SLC6A4
47 irritable bowel syndrome 9.5 HTR7 SLC6A4 TNF
48 vascular disease 8.9 ACVRL1 ADIPOQ BMPR2 EDN1 HP TNF
49 migraine with or without aura 1 8.7 HTR2B HTR7 SLC6A4 TNF

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 35)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Cor Pulmonale Acute Cystitis
Anthracosis Anxiety
Asbestosis Bronchiectasis
Bronchitis Bronchopneumonia
Chronic Myocardial Ischemia Conn's Syndrome
Deficiency Anemia Dysthymic Disorder
Esophagitis Familial Atrial Fibrillation
Heart Disease Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Idiopathic Interstitial Pneumonia
Ischemic Heart Disease Mitral Valve Disease
Oral Candidiasis Osteoporosis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sleep Apnea
Status Asthmaticus Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:



Diseases related to Chronic Pulmonary Heart Disease

Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 HTR2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.6 SLC6A4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 HTR2B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.6 EDN1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 HTR2B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.6 HTR2B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.6 SLC6A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.6 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 HTR2B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.6 EDN1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 EDN1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.6 HTR2B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 SLC6A4 EDN1 HTR2B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 EDN1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 HTR2B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.6 SLC6A4

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 BMPR2 TNF CP EDN1 HP HTR2B
2 behavior/neurological MP:0005386 9.92 ADIPOQ SLC6A4 BMPR2 TNF CP HTR7
3 homeostasis/metabolism MP:0005376 9.9 BMPR2 TNF CP TTR EDN1 HP
4 mortality/aging MP:0010768 9.65 ADIPOQ SLC6A4 BMPR2 TNF EDN1 HP
5 muscle MP:0005369 9.17 SLC6A4 BMPR2 TNF EDN1 HTR2B ACVRL1

Drugs & Therapeutics for Chronic Pulmonary Heart Disease

Drugs for Chronic Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Lactitol Investigational Phase 4 585-86-4 3871
3 Ferric Compounds Phase 4
4 Hematinics Phase 4
5 Micronutrients Phase 4
6 Pharmaceutical Solutions Phase 4
7 Trace Elements Phase 4
8
Metoprolol Approved, Investigational Phase 3 37350-58-6, 51384-51-1 4171
9 Adrenergic Agents Phase 3,Not Applicable
10 Antihypertensive Agents Phase 3,Not Applicable
11 Autonomic Agents Phase 3,Not Applicable
12 Neurotransmitter Agents Phase 3,Not Applicable
13 Peripheral Nervous System Agents Phase 3,Not Applicable
14 Adrenergic Antagonists Phase 3
15 Adrenergic beta-1 Receptor Antagonists Phase 3
16 Adrenergic beta-Antagonists Phase 3
17 Anti-Arrhythmia Agents Phase 3
18 Sympatholytics Phase 3
19 Vaccines Phase 1
20
Menthol Approved Not Applicable 2216-51-5 16666
21
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
22
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
23
Exenatide Approved, Investigational Not Applicable 141758-74-9 15991534
24
Amlodipine Approved Not Applicable 88150-42-9 2162
25
Dobutamine Approved Not Applicable 34368-04-2 36811
26
Cabergoline Approved 81409-90-7 54746
27
Dopamine Approved 51-61-6, 62-31-7 681
28
Levodopa Approved 59-92-7 6047
29 tannic acid Approved, Nutraceutical Not Applicable
30 Glucagon-Like Peptide 1 Not Applicable
31 Hormone Antagonists Not Applicable
32 Hormones Not Applicable
33 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
34 Hypoglycemic Agents Not Applicable
35 Incretins Not Applicable
36 Adrenergic Agonists Not Applicable
37 Adrenergic beta-Agonists Not Applicable
38 calcium channel blockers Not Applicable
39 Calcium, Dietary Not Applicable
40 Protective Agents Not Applicable
41 Vasodilator Agents Not Applicable
42 Dopamine Agents
43 Dopamine agonists
44 Vasoconstrictor Agents

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
2 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Recruiting NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
3 Integrated Care Program for Chronic Obstructive Pulmonary Disease Completed NCT01045213 Phase 3
4 Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Recruiting NCT02587351 Phase 3 Metoprolol succinate
5 Autologous Bronchial Basal Cell Transplantation for Treatment of COPD Recruiting NCT03188627 Phase 1, Phase 2
6 Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Recruiting NCT03092648 Phase 1, Phase 2
7 Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO Completed NCT02027129 Phase 1
8 A Phase I Randomized, Observer-Blinded, Dose-Ranging Study in Healthy Subjects 24 to <72 Months of Age Completed NCT02296463 Phase 1
9 Metabolic Changes in Patients With Chronic Cardiopulmonary Disease Unknown status NCT02550808
10 Effect of Normatec Pump for Relief of Leg Edema in Patients With Right Heart Failure Unknown status NCT00834145 Not Applicable
11 The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients Unknown status NCT02600039 Not Applicable
12 Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) Unknown status NCT01757522
13 Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale Completed NCT03243994 Not Applicable
14 The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale Completed NCT02976324 Not Applicable
15 Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease Completed NCT01554774
16 NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE) Completed NCT01633671
17 Impact of NaHCO3- on Exercise Hyperpnea Completed NCT03057535 Early Phase 1 Sodium Bicarbonate;Sodium Chloride
18 Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS) Completed NCT01553227 Not Applicable
19 World Trade Center (WTC) CHEST Completed NCT01466218
20 Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome Completed NCT01444898 Not Applicable Exenatide
21 Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF) Completed NCT01354613 Not Applicable Dobutamine;Amlodipine
22 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
23 An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation Recruiting NCT03021681 Not Applicable
24 Study of Renin-angiotensin System in Mechanically Ventilated Subjects Not yet recruiting NCT03212690 Local standard of care

Search NIH Clinical Center for Chronic Pulmonary Heart Disease

Genetic Tests for Chronic Pulmonary Heart Disease

Anatomical Context for Chronic Pulmonary Heart Disease

MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

41
Heart, Small Intestine, Endothelial

Publications for Chronic Pulmonary Heart Disease

Articles related to Chronic Pulmonary Heart Disease:

(show all 25)
# Title Authors Year
1
Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. ( 27629759 )
2016
2
Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. ( 24294047 )
2013
3
Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. ( 24142714 )
2013
4
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21860655 )
2012
5
Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21711201 )
2011
6
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. ( 19080646 )
2008
7
Hospital Stays Involving Chronic Pulmonary Heart Disease, 2005: Statistical Brief #43 ( 21755628 )
2006
8
[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. ( 12934401 )
2003
9
The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. ( 12435299 )
2002
10
Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. ( 11263275 )
2000
11
Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment. ( 7774397 )
1995
12
Effects of sustained ligustrazine on hemorrheology in patients with chronic pulmonary heart disease. ( 1453503 )
1992
13
Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease. ( 1816412 )
1991
14
[Noninvasive diagnosis of pulmonary hypertension in aged and elderly patients with chronic pulmonary heart disease]. ( 1857088 )
1991
15
Chronic pulmonary heart disease. ( 4557432 )
1972
16
Respiratory acidosis in chronic pulmonary heart disease and the red cell pattern. ( 14025248 )
1962
17
The blood-gas exchange and the pH in chronic pulmonary heart disease. ( 13883689 )
1962
18
PREDNISOLONE MAINTENANCE THERAPY IN CHRONIC PULMONARY HEART DISEASE. ( 18610137 )
1960
19
Pharmacological aspects of the pulmonary circulation in chronic pulmonary heart disease. ( 13848401 )
1959
20
The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. ( 13623896 )
1959
21
Respiratory acidosis in chronic pulmonary heart disease: pathogenesis, clinical features and management. ( 13623895 )
1959
22
[Chronic pulmonary heart disease]. ( 13231686 )
1954
23
Pneumoperitoneum in chronic pulmonary heart disease. ( 13084926 )
1953
24
Chronic pulmonary heart disease. ( 14935191 )
1952
25
Electrocardiographic appearances in acute and chronic pulmonary heart disease. ( 18880733 )
1948

Variations for Chronic Pulmonary Heart Disease

Expression for Chronic Pulmonary Heart Disease

Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.

Pathways for Chronic Pulmonary Heart Disease

GO Terms for Chronic Pulmonary Heart Disease

Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ADIPOQ BMPR2 CP EDN1 HP TNF
2 dendrite GO:0030425 9.46 ACVRL1 BMPR2 HTR2B HTR7
3 integral component of plasma membrane GO:0005887 9.17 ACVRL1 BMPR2 HTR2B HTR7 PTGIR SLC6A4

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.9 ADIPOQ EDN1 TNF TTR
2 response to drug GO:0042493 9.85 ADIPOQ EDN1 HTR2B SLC6A4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.79 ADIPOQ HTR2B TNF
4 response to organic substance GO:0010033 9.73 HP SLC6A4 TNF
5 circadian rhythm GO:0007623 9.71 ADIPOQ HTR7 SLC6A4
6 cellular response to BMP stimulus GO:0071773 9.65 ACVRL1 BMPR2
7 positive regulation of BMP signaling pathway GO:0030513 9.65 ACVRL1 BMPR2
8 blood vessel remodeling GO:0001974 9.65 ACVRL1 BMPR2
9 phosphatidylinositol 3-kinase signaling GO:0014065 9.64 EDN1 HTR2B
10 positive regulation of cytokine production GO:0001819 9.64 HTR2B TNF
11 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 9.63 EDN1 HTR2B
12 positive regulation of cytokine secretion GO:0050715 9.63 HTR2B TNF
13 positive regulation of interleukin-8 production GO:0032757 9.62 ADIPOQ TNF
14 blood vessel morphogenesis GO:0048514 9.62 ACVRL1 EDN1
15 membrane depolarization GO:0051899 9.61 ADIPOQ EDN1
16 positive regulation of endothelial cell proliferation GO:0001938 9.61 ACVRL1 BMPR2 HTR2B
17 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.59 ACVRL1 BMPR2
18 smooth muscle contraction GO:0006939 9.58 HTR2B HTR7
19 activin receptor signaling pathway GO:0032924 9.58 ACVRL1 BMPR2
20 lymphangiogenesis GO:0001946 9.57 ACVRL1 BMPR2
21 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.54 HTR2B HTR7 PTGIR
22 negative regulation of hormone secretion GO:0046888 9.52 ADIPOQ EDN1
23 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.51 ADIPOQ PTGIR
24 positive regulation of MAP kinase activity GO:0043406 9.5 EDN1 HTR2B TNF
25 artery development GO:0060840 9.49 ACVRL1 BMPR2
26 endothelial cell apoptotic process GO:0072577 9.48 BMPR2 TNF
27 retina vasculature development in camera-type eye GO:0061298 9.46 ACVRL1 BMPR2
28 response to hypoxia GO:0001666 9.46 ACVRL1 ADIPOQ EDN1 SLC6A4
29 lymphatic endothelial cell differentiation GO:0060836 9.4 ACVRL1 BMPR2
30 venous blood vessel development GO:0060841 9.26 ACVRL1 BMPR2
31 negative regulation of DNA biosynthetic process GO:2000279 9.13 ACVRL1 ADIPOQ BMPR2
32 vasoconstriction GO:0042310 8.92 EDN1 HTR2B HTR7 SLC6A4

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.61 ADIPOQ EDN1 TNF
2 hormone activity GO:0005179 9.43 ADIPOQ EDN1 TTR
3 neurotransmitter receptor activity GO:0030594 9.4 HTR2B HTR7
4 G-protein coupled serotonin receptor activity GO:0004993 9.37 HTR2B HTR7
5 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.32 ACVRL1 BMPR2
6 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVRL1 BMPR2
7 serotonin binding GO:0051378 8.96 HTR2B HTR7
8 BMP receptor activity GO:0098821 8.62 ACVRL1 BMPR2

Sources for Chronic Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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