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MCID: CHR096
MIFTS: 43

Chronic Pulmonary Heart Disease

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Chronic Pulmonary Heart Disease

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MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease 12 15 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12326
ICD9CM 34 416.8
UMLS 71 C0155673 C0238074
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Summaries for Chronic Pulmonary Heart Disease

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MalaCards based summary : Chronic Pulmonary Heart Disease is related to pulmonary tuberculosis and pulmonary hypertension, primary, 1. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are PEDF Induced Signaling and nNOS Signaling in Skeletal Muscle. Affiliated tissues include heart, skeletal muscle and lung, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

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Related Diseases for Chronic Pulmonary Heart Disease

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Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 pulmonary tuberculosis 30.6 TNF HP CP
2 pulmonary hypertension, primary, 1 30.0 SLC6A4 EDN1 BMPR2 ACVRL1
3 tricuspid valve insufficiency 30.0 PDE5A EDN1 BMPR2 ACE
4 respiratory failure 29.8 TTR TNF EDN1 ACE
5 pulmonary edema 29.7 TNF NOS3 HP EDN1 ACE
6 pulmonary disease, chronic obstructive 29.7 TNF SLC6A4 PDE5A ACE
7 arteriosclerosis 29.4 TTR NOS3 EDNRA EDN1 ADIPOQ ACE
8 heart disease 28.8 TTR TNF SMAD9 SLC6A4 PDE5A NOS3
9 pulmonary hypertension 26.1 TNF SMAD9 SLC6A4 PTGIR PDE5A NOS3
10 histoplasmosis pericarditis 10.5 TNF ACE
11 chronic thromboembolic pulmonary hypertension 10.5 EDN1 BMPR2
12 uveoparotid fever 10.4 TNF ACE
13 nutmeg liver 10.4 HP CP
14 subacute cutaneous lupus erythematosus 10.4 TNF ACE
15 nontuberculous mycobacterial lung disease 10.4 TNF ADIPOQ
16 dysentery 10.4 TTR TNF HP
17 conjunctival deposit 10.4 TTR ACE
18 posterior scleritis 10.4 TNF ACE
19 vasculogenic impotence 10.4 PDE5A ACE
20 glossitis 10.4 TTR TNF SLC6A4
21 obstructive jaundice 10.4 TTR TNF EDN1
22 melancholia 10.4 TNF SLC6A4 HP
23 background diabetic retinopathy 10.4 TNF EDN1 ACE
24 idiopathic edema 10.4 EDN1 ADIPOQ ACE
25 skin sarcoidosis 10.3 TNF ACE
26 pericarditis 10.3 TNF ADIPOQ ACE
27 pericardium disease 10.3 TTR TNF ACE
28 melkersson-rosenthal syndrome 10.3 TNF ACE
29 raynaud phenomenon 10.3 PDE5A EDN1
30 complex regional pain syndrome 10.3 TNF EDN1 ACE
31 prostatitis 10.3 TNF PDE5A ADIPOQ
32 raynaud disease 10.3 PDE5A EDN1 ACE
33 rheumatic fever 10.3 TNF HP ACE
34 pure autonomic failure 10.3 TTR PDE5A ACE
35 psychosexual disorder 10.3 SLC6A4 PDE5A HTR2B
36 mixed connective tissue disease 10.3 TNF BMPR2 ACVRL1
37 vein disease 10.3 TNF EDN1 ACE
38 retinal vein occlusion 10.3 TNF EDN1 ACE
39 protein-energy malnutrition 10.3 TTR TNF HP CP
40 posterior urethral valves 10.3 TNF ACE
41 hypoactive sexual desire disorder 10.3 PDE5A HTR2B
42 prediabetes syndrome 10.3 TNF ADIPOQ ACE
43 syphilis 10.3 TNF CP ACE
44 hepatic encephalopathy 10.3 TTR TNF PDE5A
45 pulmonary arterial hypertension associated with connective tissue disease 10.3 EDNRB EDNRA
46 bronchitis 10.3
47 nutritional deficiency disease 10.3 TTR CP ADIPOQ
48 penile disease 10.3 TNF PDE5A NOS3
49 priapism 10.2 PDE5A NOS3 HP
50 renovascular hypertension 10.2 NOS3 EDN1 ACE

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 33)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Cor Pulmonale Acute Cystitis
Anthracosis Anxiety
Asbestosis Bronchiectasis
Bronchitis Bronchopneumonia
Conn's Syndrome Deficiency Anemia
Dysthymic Disorder Esophagitis
Familial Atrial Fibrillation Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypothyroidism
Idiopathic Interstitial Pneumonia Mitral Valve Disease
Oral Candidiasis Osteoporosis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sleep Apnea
Status Asthmaticus Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:



Diseases related to Chronic Pulmonary Heart Disease
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Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

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GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.5 ACVR1 ACVRL1 BMPR1B BMPR2
2 Decreased substrate adherent cell growth GR00193-A-3 9.5 ACVR1
3 Decreased substrate adherent cell growth GR00193-A-4 9.5 ACVR1 ACVRL1 BMPR1B
4 Decreased cell viability after pRB stimulation GR00230-A-1 8.96 ACVRL1 BMPR2

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.51 ACE ACVR1 ACVRL1 ADIPOQ BMPR2 CP
2 homeostasis/metabolism MP:0005376 10.42 ACE ACVR1 ACVRL1 ADIPOQ BMPR2 CP
3 behavior/neurological MP:0005386 10.4 ACE ACVR1 ACVRL1 ADIPOQ BMPR2 CP
4 growth/size/body region MP:0005378 10.4 ACE ACVR1 ACVRL1 ADIPOQ BMPR1B BMPR2
5 mortality/aging MP:0010768 10.36 ACE ACVR1 ACVRL1 ADIPOQ BMPR1B BMPR2
6 cellular MP:0005384 10.35 ACVR1 ADIPOQ BMPR1B BMPR2 CP EDNRA
7 embryo MP:0005380 10.29 ACE ACVR1 ACVRL1 BMPR1B BMPR2 EDN1
8 hematopoietic system MP:0005397 10.29 ACE ACVRL1 ADIPOQ BMPR2 CP EDNRA
9 immune system MP:0005387 10.29 ACE ACVR1 ADIPOQ BMPR2 CP EDNRA
10 endocrine/exocrine gland MP:0005379 10.28 ACE ADIPOQ BMPR1B EDN1 EDNRA EDNRB
11 digestive/alimentary MP:0005381 10.21 ACVR1 ACVRL1 EDN1 EDNRA EDNRB NOS3
12 muscle MP:0005369 10.18 ACVR1 ACVRL1 ADIPOQ BMPR2 EDN1 EDNRA
13 craniofacial MP:0005382 10.17 ACVR1 ACVRL1 BMPR1B EDN1 EDNRA EDNRB
14 nervous system MP:0003631 10.13 ACVR1 ACVRL1 ADIPOQ BMPR1B BMPR2 CP
15 liver/biliary system MP:0005370 10 ACE ACVRL1 ADIPOQ CP HP NOS3
16 neoplasm MP:0002006 9.97 ACE ACVR1 ADIPOQ EDNRB HP PTGIR
17 normal MP:0002873 9.96 ACVRL1 BMPR1B BMPR2 EDN1 EDNRA HTR2B
18 renal/urinary system MP:0005367 9.85 ACE ACVRL1 ADIPOQ BMPR2 EDN1 EDNRA
19 respiratory system MP:0005388 9.56 ACVRL1 ADIPOQ BMPR2 EDNRA EDNRB NOS3
20 skeleton MP:0005390 9.36 ACVR1 ADIPOQ BMPR1B BMPR2 EDN1 EDNRA
Sources

Drugs & Therapeutics for Chronic Pulmonary Heart Disease

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Traditional Chinese Medicine on Bronchiectasis Patients: A Multi-center, Randomized, Double-blind, Controlled Trial Not yet recruiting NCT03443531 Phase 3 Bufei Huatan granule;Yifei Qinghua granule;Placebo Bufei Huatan granule;Placebo Yifei Qinghua granule
2 Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT03092648 Phase 1, Phase 2
3 A Single-centered, Non-randomized, Concurrent Control Study on Autologous Bronchial Basal Cell Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Completed NCT03188627 Phase 1, Phase 2
4 Autologous Transplantation of Bronchial Basal Cells for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Not yet recruiting NCT03655795 Phase 1
5 Metabolic and Histological Changes in Skeletal Muscle and Fat Tissue in Patients With Chronic Cardiopulmonary Disease Unknown status NCT02550808
6 Huai'an First People 's Hospital,Nanjing Medical University Recruiting NCT03021681

Search NIH Clinical Center for Chronic Pulmonary Heart Disease

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Genetic Tests for Chronic Pulmonary Heart Disease

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Anatomical Context for Chronic Pulmonary Heart Disease

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MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

40
Heart, Skeletal Muscle, Lung, Testes, Cortex, Adrenal Cortex, Bone
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Publications for Chronic Pulmonary Heart Disease

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Articles related to Chronic Pulmonary Heart Disease:

(show top 50) (show all 275)
# Title Authors PMID Year
1
[Clinical significance of the N-terminal pro-B-type natriuretic peptide levels in pneumoconiosis patients with chronic pulmonary heart disease]. 61
31594135 2019
2
Unbiased Phenome-Wide Association Studies of Red Cell Distribution Width Identifies Key Associations with Pulmonary Hypertension. 61
30608875 2019
3
N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) as a Diagnostic Biomarker of Left Ventricular Systolic Dysfunction in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). 61
29951921 2018
4
Healthcare resource utilization and costs for patients with pulmonary arterial hypertension: real-world documentation of functional class. 61
28762848 2017
5
Is the Mortality Trend of Ischemic Heart Disease by the GBD2013 Study in China Real? 61
28427490 2017
6
Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. 61
27629759 2016
7
Predictors of costs from the hospital perspective of primary pulmonary embolism. 61
26493784 2016
8
[Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background]. 61
27245017 2015
9
Characterizing pulmonary hypertension-related hospitalization costs among Medicare Advantage or commercially insured patients with pulmonary arterial hypertension: a retrospective database study. 61
25734573 2015
10
[Chronic pulmonary heart disease complicating hydatic embolism]. 61
25553612 2015
11
[Study on tissue Doppler imaging in diagnosis of right ventricular hypertrophy in patients with silicosis complicated by chronic pulmonary heart disease]. 61
25608902 2014
12
Variation of the upper airways in pediatric patients with OSAS and retrusion of the midface. 61
23416423 2014
13
Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. 61
24142714 2013
14
[Spontaneous reporting system data analysis of parenterally administered Shenmai]. 61
24471317 2013
15
[Two-dimensional ultrasound speckle tracking imaging in detection of myocardial torsion for patients with chronic pulmonary heart disease]. 61
24167141 2013
16
[Risk factors for in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease]. 61
24025500 2013
17
Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. 61
24294047 2013
18
[Chronic pulmonary heart disease. Does it require cardiologist's attention?]. 61
23348542 2013
19
[Quantitative analysis of systolic function of right ventricular walls in patients with pneumoconiosis combined with chronic pulmonary heart disease and its diagnostic value]. 61
23290652 2012
20
[The role of 4-hydroxynonenal in assessment of chronic obstructive pulmonary disease severity]. 61
23289993 2012
21
[The influence shuxuetong on the membrane viscoelasticity of erythrocyte taken from patients with chronic pulmonary heart disease]. 61
22404024 2012
22
[Use of trental for correction of disorders in the system of hemostasys in patients with fibro-cavernous tuberculosis and chronic pulmonary heart]. 61
22392780 2012
23
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. 61
21860655 2012
24
Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. 61
21711201 2011
25
[Retrospective study on the prevalence of cardiovascular comorbidities in 4960 inpatients with chronic obstructive pulmonary disease in Beijing]. 61
21457669 2011
26
Application of a new pulmonary artery obstruction score in the prognostic evaluation of acute pulmonary embolism: comparison with clinical and haemodynamic parameters. 61
21311989 2011
27
[Changes of neurotransmitter endothelin, thromboxance B2 and 6-keto-prostaglandin F1 alpha in patients with chronic pulmonary heart disease]. 61
20584647 2010
28
[Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease]. 61
20669672 2010
29
[Predictive value of admission amino-terminal pro-B-type natriuretic peptide on in-hospital mortality in patients with decompensated heart failure]. 61
19927625 2009
30
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. 61
19080646 2008
31
[Heart failure in elderly patients in Brazzaville, Congo: clinical and etiologic aspects and outcome]. 61
18689317 2008
32
Depression of chronic medical inpatients in China. 61
18207055 2008
33
[Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease]. 61
16970099 2006
34
[Clinical significance of 2,3-biphosphoglyceric acid content in erythrocytes of patients with chronic pulmonary heart disease]. 61
17380866 2006
35
[A pilot survey of the main causes of chronic heart failure in patients treated in primary hospitals in China]. 61
16080834 2005
36
[Effect of xingding injection on platelet coagulation and fibrinolysis activity in patients with advanced stage chronic pulmonary heart disease]. 61
15015454 2004
37
[Correction of hemodynamic disorders in phthisiologic surgical patients with chronic pulmonary heart disease in preoperative period]. 61
12939935 2003
38
[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. 61
12934401 2003
39
The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. 61
12435299 2002
40
[Pathogen variance and drug-sensibility analysis of lower-respiratory-tract bacterial infection in chronic pulmonary heart disease]. 61
12575239 2002
41
[A multicenter clinical study on clinical effects of meglumine cyclic adenylate in treating patients with chronic pulmonary heart disease]. 61
11798617 2001
42
[Efficacy of prostaglandin E1 in the treatment of chronic pulmonary heart disease in the elderly people at the acute stage]. 61
12536711 2001
43
[New aspects of combined therapy of chronic pulmonary heart disease]. 61
11763563 2001
44
Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. 61
11263275 2000
45
[Study of plasma neuron-specific enolase activity of patients with chronic pulmonary heart disease complicated by pulmonary encephalopathy]. 61
12212168 2000
46
[Post-embolic chronic pulmonary heart disease: a case report]. 61
12555317 2000
47
[Clinical study of fibrinolysis indicators in patients with chronic pulmonary heart disease]. 61
11776520 1999
48
[Long-term oxygen inhalation therapy and home artificial respiration for chronic pulmonary heart disease]. 61
10429918 1999
49
[Chronic pulmonary heart disease. Epidemiology, physiopathology and clinical aspects]. 61
10429914 1999
50
[Diagnosis of chronic pulmonary heart disease]. 61
10429915 1999
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Variations for Chronic Pulmonary Heart Disease

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Expression for Chronic Pulmonary Heart Disease

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Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.
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Pathways for Chronic Pulmonary Heart Disease

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Pathways related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 63
Show member pathways
 13.49 TNF NOS3 EDNRB EDNRA EDN1 BMPR2
2
nNOS Signaling in Skeletal Muscle 63
Show member pathways
 12.48 TNF SMAD9 BMPR2 BMPR1B ACVRL1 ACVR1
3
Oxytocin signaling pathway 36
Show member pathways
 12.35 PTGIR NOS3 EDNRA EDN1
4
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.31 SMAD9 BMPR2 BMPR1B ACVR1
5
Calcium signaling pathway 36
Show member pathways
 12.11 NOS3 HTR2B EDNRB EDNRA
6
Signaling pathways regulating pluripotency of stem cells 36
11.91 SMAD9 BMPR2 BMPR1B ACVR1
7
AGE-RAGE signaling pathway in diabetic complications 36
11.75 TNF NOS3 EDN1
8
TGF-beta signaling pathway (KEGG) 36
11.69 TNF SMAD9 BMPR2 BMPR1B ACVR1
9
Signaling by BMP 65
Show member pathways
 11.58 SMAD9 BMPR2 BMPR1B
10
Fluid shear stress and atherosclerosis 36
11.58 TNF NOS3 EDN1 BMPR2 BMPR1B ACVR1
11
Renin secretion 36
11.55 EDNRA EDN1 ACE
12
Adipocytokine signaling pathway 36
11.54 TNF G6PC3 ADIPOQ
13
Endothelins 1
11.38 EDNRB EDNRA EDN1
14
Prostaglandin Synthesis and Regulation 1
11.03 PTGIR EDNRB EDNRA EDN1
15
Cardiomyocyte Differentiation through BMP Receptors 63
10.95 SMAD9 BMPR2 BMPR1B
16
ALK1 signaling events 1
Show member pathways
 10.89 SMAD9 BMPR2 ACVRL1 ACVR1
17
NO-dependent CFTR activation (normal and CF) 22
10.67 PDE5A NOS3
18
ALK2 signaling events 1
10.59 SMAD9 BMPR2 ACVR1
19
Endothelin Pathways 1
10.55 PTGIR NOS3 EDNRB EDNRA EDN1
Sources

GO Terms for Chronic Pulmonary Heart Disease

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Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TNF SLC6A4 PTGIR NOS3 HTR2B EDNRB
2 extracellular space GO:0005615 9.97 TTR TNF HP EDN1 CP BMPR2
3 cell GO:0005623 9.7 PTGIR NOS3 HTR2B EDNRB EDNRA EDN1
4 receptor complex GO:0043235 9.62 BMPR2 BMPR1B ACVRL1 ACVR1
5 integral component of plasma membrane GO:0005887 9.32 TNF SLC6A4 PTGIR HTR2B EDNRB EDNRA
6 BMP receptor complex GO:0070724 8.96 ACVRL1 ACVR1

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.96 HTR2B EDNRA EDN1 ACVRL1 ACVR1
2 in utero embryonic development GO:0001701 9.95 NOS3 EDNRA EDN1 ACVRL1 ACVR1
3 response to lipopolysaccharide GO:0032496 9.94 PTGIR NOS3 EDNRB EDN1
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.92 PTGIR EDNRB EDNRA EDN1
5 response to hypoxia GO:0001666 9.89 SLC6A4 EDNRA EDN1 ADIPOQ ACVRL1
6 response to organic substance GO:0010033 9.88 TNF SLC6A4 HP
7 calcium-mediated signaling GO:0019722 9.87 HTR2B EDNRB EDN1
8 transforming growth factor beta receptor signaling pathway GO:0007179 9.87 SMAD9 BMPR2 ACVRL1 ACVR1
9 positive regulation of endothelial cell proliferation GO:0001938 9.86 HTR2B BMPR2 ACVRL1
10 positive regulation of osteoblast differentiation GO:0045669 9.83 BMPR2 BMPR1B ACVR1
11 cellular response to growth factor stimulus GO:0071363 9.81 BMPR2 BMPR1B ACVRL1 ACVR1
12 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 BMPR2 ACVRL1 ACVR1
13 neural crest cell migration GO:0001755 9.8 HTR2B EDNRB ACVR1
14 ventricular septum morphogenesis GO:0060412 9.77 NOS3 BMPR2 ACVR1
15 positive regulation of bone mineralization GO:0030501 9.76 BMPR2 BMPR1B ACVR1
16 positive regulation of MAP kinase activity GO:0043406 9.76 TNF PDE5A HTR2B EDN1
17 branching involved in blood vessel morphogenesis GO:0001569 9.75 EDNRA EDN1 ACVR1
18 dorsal/ventral pattern formation GO:0009953 9.73 EDN1 BMPR1B ACVRL1 ACVR1
19 BMP signaling pathway GO:0030509 9.72 SMAD9 BMPR2 BMPR1B ACVRL1 ACVR1
20 enteric nervous system development GO:0048484 9.71 EDNRB EDNRA
21 positive regulation of renal sodium excretion GO:0035815 9.71 EDNRB EDN1
22 activin receptor signaling pathway GO:0032924 9.71 BMPR2 ACVRL1 ACVR1
23 positive regulation of urine volume GO:0035810 9.7 EDNRB EDN1
24 atrioventricular valve morphogenesis GO:0003181 9.7 BMPR2 ACVR1
25 acute inflammatory response GO:0002526 9.7 HP ACVR1
26 endocardial cushion morphogenesis GO:0003203 9.7 NOS3 ACVRL1 ACVR1
27 lymphangiogenesis GO:0001946 9.69 BMPR2 ACVRL1
28 negative regulation of hormone secretion GO:0046888 9.69 EDN1 ADIPOQ
29 artery smooth muscle contraction GO:0014824 9.68 EDNRA EDN1
30 artery development GO:0060840 9.68 BMPR2 ACVRL1
31 regulation of glucose transmembrane transport GO:0010827 9.68 EDNRA EDN1
32 endothelial cell apoptotic process GO:0072577 9.67 TNF BMPR2
33 retina vasculature development in camera-type eye GO:0061298 9.67 BMPR2 ACVRL1
34 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.67 PTGIR ADIPOQ
35 blood vessel remodeling GO:0001974 9.67 NOS3 BMPR2 ACVRL1 ACE
36 mitral valve morphogenesis GO:0003183 9.66 BMPR2 ACVR1
37 lymphatic endothelial cell differentiation GO:0060836 9.65 BMPR2 ACVRL1
38 epithelial fluid transport GO:0042045 9.65 EDNRB EDN1
39 negative regulation of cellular protein metabolic process GO:0032269 9.65 EDNRB EDN1
40 negative regulation of DNA biosynthetic process GO:2000279 9.65 BMPR2 ADIPOQ ACVRL1
41 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.64 NOS3 EDN1
42 negative regulation of chondrocyte proliferation GO:1902731 9.63 BMPR2 BMPR1B
43 venous blood vessel development GO:0060841 9.61 BMPR2 ACVRL1
44 endochondral bone morphogenesis GO:0060350 9.61 BMPR2 BMPR1B
45 vein smooth muscle contraction GO:0014826 9.6 EDNRB EDN1
46 endothelin receptor signaling pathway GO:0086100 9.58 EDNRB EDNRA EDN1
47 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.56 BMPR2 BMPR1B ACVRL1 ACVR1
48 cellular response to BMP stimulus GO:0071773 9.55 SMAD9 BMPR2 BMPR1B ACVRL1 ACVR1
49 regulation of blood pressure GO:0008217 9.43 NOS3 EDNRB EDNRA EDN1 ACVRL1 ACE
50 vasoconstriction GO:0042310 9.02 SLC6A4 HTR2B EDNRB EDNRA EDN1

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SMAD binding GO:0046332 9.5 BMPR1B ACVRL1 ACVR1
2 activin binding GO:0048185 9.46 ACVRL1 ACVR1
3 serotonin binding GO:0051378 9.43 SLC6A4 HTR2B
4 transforming growth factor beta-activated receptor activity GO:0005024 9.4 BMPR2 ACVRL1
5 BMP receptor activity GO:0098821 9.37 BMPR2 ACVRL1
6 activin receptor activity, type I GO:0016361 9.26 ACVRL1 ACVR1
7 endothelin receptor activity GO:0004962 9.16 EDNRB EDNRA
8 transforming growth factor beta receptor activity, type I GO:0005025 9.13 BMPR1B ACVRL1 ACVR1
9 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.92 BMPR2 BMPR1B ACVRL1 ACVR1
Sources

Sources for Chronic Pulmonary Heart Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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