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MCID: CHR096
MIFTS: 41

Chronic Pulmonary Heart Disease

Categories: Cardiovascular diseases, Respiratory diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Chronic Pulmonary Heart Disease

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MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease 12 15 70

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12326
ICD9CM 34 416.8
SNOMED-CT 67 194887007
UMLS 70 C0155673 C0238074
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Summaries for Chronic Pulmonary Heart Disease

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MalaCards based summary : Chronic Pulmonary Heart Disease is related to pulmonary tuberculosis and pulmonary hypertension, primary, 1. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are PEDF Induced Signaling and DREAM Repression and Dynorphin Expression. Affiliated tissues include heart, cortex and adrenal cortex, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

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Related Diseases for Chronic Pulmonary Heart Disease

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Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 pulmonary tuberculosis 30.8 TNF HP CP
2 pulmonary hypertension, primary, 1 30.1 SMAD9 BMPR2 ACVRL1
3 arteriosclerosis 29.9 TTR EDNRA EDN1 ADIPOQ ACE
4 pulmonary edema 29.7 TNF NPPB HP EDN1 ACE
5 respiratory failure 29.6 TTR TNF NPPB EDN1 ACE
6 tricuspid valve insufficiency 29.4 PDE5A NPPB EDNRA EDN1 BMPR2 ACE
7 heart disease 27.4 TTR TNF SMAD9 SLC6A4 PDE5A NPPB
8 pulmonary hypertension 26.9 TNF SMAD9 SLC6A4 PDE5A NPPB HTR2B
9 bronchitis 10.4
10 eisenmenger syndrome 10.4 EDN1 BMPR2
11 anterior scleritis 10.3 TNF ACE
12 conjunctival deposit 10.3 TTR ACE
13 pulmonary arteriovenous malformation 10.3 BMPR2 ACVRL1
14 posterior scleritis 10.3 TNF ACE
15 vasculogenic impotence 10.3 PDE5A ACE
16 dysentery 10.3 TTR TNF HP
17 meconium aspiration syndrome 10.3 TNF PDE5A EDN1
18 obstructive jaundice 10.3 TTR TNF EDN1
19 nontuberculous mycobacterial lung disease 10.3 TNF ADIPOQ
20 hepatic vascular disease 10.3 TNF EDN1 BMPR2
21 glossitis 10.3 TTR TNF SLC6A4
22 bladder neck obstruction 10.3 PDE5A ACE
23 melancholia 10.3 TNF SLC6A4 HP
24 skin sarcoidosis 10.3 TNF ACE
25 background diabetic retinopathy 10.3 TNF EDN1 ACE
26 melkersson-rosenthal syndrome 10.3 TNF ACE
27 complex regional pain syndrome 10.3 TNF EDN1 ACE
28 takayasu arteritis 10.3 TNF HP EDN1
29 vein disease 10.3 TNF EDN1 ACE
30 pulmonary arterial hypertension associated with connective tissue disease 10.3 EDNRB EDNRA
31 retinal vein occlusion 10.3 TNF EDN1 ACE
32 diaphragm disease 10.3 PDE5A EDNRA EDN1
33 eclampsia 10.3 TNF EDN1 ACE
34 pure autonomic failure 10.2 TTR PDE5A ACE
35 syphilis 10.2 TNF CP ACE
36 hepatic encephalopathy 10.2 TTR TNF PDE5A
37 hypoactive sexual desire disorder 10.2 PDE5A HTR2B
38 malignant renovascular hypertension 10.2 EDNRA EDN1
39 pulmonary emphysema 10.2
40 carotid stenosis 10.2 TNF ADIPOQ ACE
41 limb ischemia 10.2 TNF EDN1 ACE
42 nutritional deficiency disease 10.2 TTR CP ADIPOQ
43 granulomatous hepatitis 10.2 TNF ACE
44 bullous impetigo 10.2 EDNRB EDNRA
45 migraine without aura 10.2 TNF SLC6A4 EDNRA
46 protein-energy malnutrition 10.2 TTR TNF HP CP
47 nonarteritic anterior ischemic optic neuropathy 10.2 PDE5A EDN1 ACE
48 wilson disease 10.2 TNF HP CP
49 posterior urethral valves 10.2 TNF ACE
50 psychosexual disorder 10.2 SLC6A4 PDE5A HTR2B

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 33)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Cor Pulmonale Acute Cystitis
Anthracosis Anxiety
Asbestosis Bronchiectasis
Bronchitis Bronchopneumonia
Conn's Syndrome Deficiency Anemia
Dysthymic Disorder Esophagitis
Familial Atrial Fibrillation Heart Disease
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Hypothyroidism
Idiopathic Interstitial Pneumonia Mitral Valve Disease
Oral Candidiasis Osteoporosis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sleep Apnea
Status Asthmaticus Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:



Diseases related to Chronic Pulmonary Heart Disease
Sources

Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

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GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.5 ACVR1 ACVRL1 BMPR1B BMPR2
2 Decreased substrate adherent cell growth GR00193-A-3 9.5 ACVR1
3 Decreased substrate adherent cell growth GR00193-A-4 9.5 ACVR1 ACVRL1 BMPR1B
4 Decreased cell viability after pRB stimulation GR00230-A-1 8.96 ACVRL1 BMPR2

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.47 ACE ACVR1 ACVRL1 ADIPOQ BMP4 BMPR2
2 homeostasis/metabolism MP:0005376 10.38 ACE ACVR1 ACVRL1 ADIPOQ BMP4 BMPR2
3 growth/size/body region MP:0005378 10.37 ACE ACVR1 ACVRL1 ADIPOQ BMP4 BMPR1B
4 mortality/aging MP:0010768 10.36 ACE ACVR1 ACVRL1 ADIPOQ BMP4 BMPR1B
5 cellular MP:0005384 10.34 ACVR1 ADIPOQ BMP4 BMPR1B BMPR2 CP
6 embryo MP:0005380 10.3 ACE ACVR1 ACVRL1 BMP4 BMPR1B BMPR2
7 endocrine/exocrine gland MP:0005379 10.25 ACE ADIPOQ BMP4 BMPR1B EDN1 EDNRA
8 nervous system MP:0003631 10.24 ACE ACVR1 ACVRL1 ADIPOQ BMP4 BMPR1B
9 muscle MP:0005369 10.21 ACVR1 ACVRL1 ADIPOQ BMP4 BMPR2 EDN1
10 craniofacial MP:0005382 10.2 ACVR1 ACVRL1 BMP4 BMPR1B EDN1 EDNRA
11 digestive/alimentary MP:0005381 10.19 ACVR1 ACVRL1 BMP4 EDN1 EDNRA EDNRB
12 normal MP:0002873 10.02 ACVRL1 BMP4 BMPR1B BMPR2 EDN1 EDNRA
13 renal/urinary system MP:0005367 9.96 ACE ACVRL1 ADIPOQ BMP4 BMPR2 EDN1
14 neoplasm MP:0002006 9.95 ACE ACVR1 ADIPOQ EDNRB HP SMAD9
15 respiratory system MP:0005388 9.76 ACVRL1 ADIPOQ BMP4 BMPR2 EDNRA EDNRB
16 skeleton MP:0005390 9.7 ACVR1 ADIPOQ BMP4 BMPR1B BMPR2 EDN1
17 vision/eye MP:0005391 9.28 ACE BMP4 BMPR1B BMPR2 CP EDNRA
Sources

Drugs & Therapeutics for Chronic Pulmonary Heart Disease

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Search Clinical Trials , NIH Clinical Center for Chronic Pulmonary Heart Disease

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Genetic Tests for Chronic Pulmonary Heart Disease

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Anatomical Context for Chronic Pulmonary Heart Disease

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MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

40
Heart, Cortex, Adrenal Cortex, Brain, Kidney, Endothelial
Sources

Publications for Chronic Pulmonary Heart Disease

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Articles related to Chronic Pulmonary Heart Disease:

(show top 50) (show all 280)
# Title Authors PMID Year
1
Application of Gastroscopy Based on Nano Carbon in the Remedy of Chronic Pulmonary Heart Disease Caused by Helicobacter Pylori. 61
33183452 2021
2
Chinese herbal medicine injections (CHMIs) for chronic pulmonary heart disease: A protocol for a Bayesian network meta-analysis. 61
33546022 2021
3
Splenic infarction associated with obstructive sleep apnoea/hypopnoea syndrome: a case report. 61
33050767 2020
4
Comorbidity Associations with AATD Among Commercially Insured and Medicare Beneficiaries with COPD in the US. 61
33116454 2020
5
[Clinical significance of the N-terminal pro-B-type natriuretic peptide levels in pneumoconiosis patients with chronic pulmonary heart disease]. 61
31594135 2019
6
Unbiased Phenome-Wide Association Studies of Red Cell Distribution Width Identifies Key Associations with Pulmonary Hypertension. 61
30608875 2019
7
N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) as a Diagnostic Biomarker of Left Ventricular Systolic Dysfunction in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD). 61
29951921 2018
8
Healthcare resource utilization and costs for patients with pulmonary arterial hypertension: real-world documentation of functional class. 61
28762848 2017
9
Is the Mortality Trend of Ischemic Heart Disease by the GBD2013 Study in China Real? 61
28427490 2017
10
Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. 61
27629759 2016
11
Predictors of costs from the hospital perspective of primary pulmonary embolism. 61
26493784 2016
12
[Post-marketing clinical safety assessment of Shenmai injection based on active monitoring and passive monitoring in large data background]. 61
27245017 2015
13
Characterizing pulmonary hypertension-related hospitalization costs among Medicare Advantage or commercially insured patients with pulmonary arterial hypertension: a retrospective database study. 61
25734573 2015
14
[Chronic pulmonary heart disease complicating hydatic embolism]. 61
25553612 2015
15
[Study on tissue Doppler imaging in diagnosis of right ventricular hypertrophy in patients with silicosis complicated by chronic pulmonary heart disease]. 61
25608902 2014
16
Variation of the upper airways in pediatric patients with OSAS and retrusion of the midface. 61
23416423 2014
17
Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. 61
24142714 2013
18
[Two-dimensional ultrasound speckle tracking imaging in detection of myocardial torsion for patients with chronic pulmonary heart disease]. 61
24167141 2013
19
[Spontaneous reporting system data analysis of parenterally administered Shenmai]. 61
24471317 2013
20
[Risk factors for in-hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease]. 61
24025500 2013
21
Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. 61
24294047 2013
22
[Chronic pulmonary heart disease. Does it require cardiologist's attention?]. 61
23348542 2013
23
[Quantitative analysis of systolic function of right ventricular walls in patients with pneumoconiosis combined with chronic pulmonary heart disease and its diagnostic value]. 61
23290652 2012
24
[The role of 4-hydroxynonenal in assessment of chronic obstructive pulmonary disease severity]. 61
23289993 2012
25
[The influence shuxuetong on the membrane viscoelasticity of erythrocyte taken from patients with chronic pulmonary heart disease]. 61
22404024 2012
26
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. 61
21860655 2012
27
[Use of trental for correction of disorders in the system of hemostasys in patients with fibro-cavernous tuberculosis and chronic pulmonary heart]. 61
22392780 2012
28
Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. 61
21711201 2011
29
[Retrospective study on the prevalence of cardiovascular comorbidities in 4960 inpatients with chronic obstructive pulmonary disease in Beijing]. 61
21457669 2011
30
Application of a new pulmonary artery obstruction score in the prognostic evaluation of acute pulmonary embolism: comparison with clinical and haemodynamic parameters. 61
21311989 2011
31
[Changes of neurotransmitter endothelin, thromboxance B2 and 6-keto-prostaglandin F1 alpha in patients with chronic pulmonary heart disease]. 61
20584647 2010
32
[Effects of tetramethylpyrazine on fractalkine and tumor necrosis factor-alpha expression in patients with chronic pulmonary heart disease]. 61
20669672 2010
33
[Predictive value of admission amino-terminal pro-B-type natriuretic peptide on in-hospital mortality in patients with decompensated heart failure]. 61
19927625 2009
34
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. 61
19080646 2008
35
[Heart failure in elderly patients in Brazzaville, Congo: clinical and etiologic aspects and outcome]. 61
18689317 2008
36
Depression of chronic medical inpatients in China. 61
18207055 2008
37
[Clinical observation on shufei granule in improving right ventricular function of patients with chronic pulmonary heart disease]. 61
16970099 2006
38
[Clinical significance of 2,3-biphosphoglyceric acid content in erythrocytes of patients with chronic pulmonary heart disease]. 61
17380866 2006
39
[A pilot survey of the main causes of chronic heart failure in patients treated in primary hospitals in China]. 61
16080834 2005
40
[Effect of xingding injection on platelet coagulation and fibrinolysis activity in patients with advanced stage chronic pulmonary heart disease]. 61
15015454 2004
41
[Correction of hemodynamic disorders in phthisiologic surgical patients with chronic pulmonary heart disease in preoperative period]. 61
12939935 2003
42
[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. 61
12934401 2003
43
The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. 61
12435299 2002
44
[Pathogen variance and drug-sensibility analysis of lower-respiratory-tract bacterial infection in chronic pulmonary heart disease]. 61
12575239 2002
45
[A multicenter clinical study on clinical effects of meglumine cyclic adenylate in treating patients with chronic pulmonary heart disease]. 61
11798617 2001
46
[Efficacy of prostaglandin E1 in the treatment of chronic pulmonary heart disease in the elderly people at the acute stage]. 61
12536711 2001
47
[New aspects of combined therapy of chronic pulmonary heart disease]. 61
11763563 2001
48
Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. 61
11263275 2000
49
[Study of plasma neuron-specific enolase activity of patients with chronic pulmonary heart disease complicated by pulmonary encephalopathy]. 61
12212168 2000
50
[Post-embolic chronic pulmonary heart disease: a case report]. 61
12555317 2000
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Variations for Chronic Pulmonary Heart Disease

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Expression for Chronic Pulmonary Heart Disease

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Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.
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Pathways for Chronic Pulmonary Heart Disease

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Pathways related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 63
Show member pathways
 13.54 TNF EDNRB EDNRA EDN1 BMPR2 BMPR1B
2
DREAM Repression and Dynorphin Expression 63
Show member pathways
 12.46 TNF SMAD9 BMPR2 BMPR1B BMP4 ACVRL1
3
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.29 SMAD9 NPPB BMPR2 BMPR1B BMP4 ACVR1
4
Wnt / Hedgehog / Notch 4
12.09 SMAD9 BMPR2 BMP4 ACVR1
5
Signaling pathways regulating pluripotency of stem cells 36
11.96 SMAD9 BMPR2 BMPR1B BMP4 ACVR1
6
Fluid shear stress and atherosclerosis 36
11.78 TNF EDN1 BMPR2 BMPR1B BMP4 ACVR1
7
Signaling by BMP 65
Show member pathways
 11.61 SMAD9 BMPR2 BMPR1B
8
Renin secretion 36
11.58 EDNRA EDN1 ACE
9
Adipocytokine signaling pathway 36
11.57 TNF G6PC3 ADIPOQ
10
TGF-beta Receptor Signaling (WikiPathways) 1
11.48 TNF SMAD9 BMP4
11
Endothelins 1
11.41 EDNRB EDNRA EDN1
12
TGF-beta signaling pathway (KEGG) 36
11.41 TNF SMAD9 BMPR2 BMPR1B BMP4 ACVR1
13
Endothelin Pathways 1
11.2 EDNRB EDNRA EDN1
14
Prostaglandin Synthesis and Regulation 1
11.13 EDNRB EDNRA EDN1
15
Differentiation of white and brown adipocyte 1
11.03 SMAD9 BMP4 ADIPOQ
16
ALK1 signaling events 1
Show member pathways
 10.99 SMAD9 BMPR2 ACVRL1 ACVR1
17
ALK2 signaling events 1
10.65 SMAD9 BMPR2 ACVR1
18
Cardiomyocyte Differentiation through BMP Receptors 63
10.36 SMAD9 NPPB BMPR2 BMPR1B BMP4
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GO Terms for Chronic Pulmonary Heart Disease

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Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 TTR TNF NPPB HP EDN1 CP
2 extracellular space GO:0005615 9.65 TTR TNF NPPB HP EDN1 CP
3 receptor complex GO:0043235 9.56 BMPR2 BMPR1B ACVRL1 ACVR1
4 integral component of plasma membrane GO:0005887 9.28 TNF SLC6A4 HTR2B EDNRB EDNRA BMPR2
5 BMP receptor complex GO:0070724 9.16 ACVRL1 ACVR1

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.22 TNF EDN1 BMPR2 BMPR1B BMP4 ACVRL1
2 negative regulation of gene expression GO:0010629 10.03 TNF EDN1 BMP4 ACVRL1 ACE
3 in utero embryonic development GO:0001701 10 EDNRA EDN1 ACVRL1 ACVR1
4 positive regulation of protein phosphorylation GO:0001934 9.98 TNF EDNRB BMP4 ADIPOQ
5 response to hypoxia GO:0001666 9.95 SLC6A4 EDNRA EDN1 ADIPOQ ACVRL1
6 heart development GO:0007507 9.93 HTR2B EDNRA EDN1 BMP4 ACVRL1 ACVR1
7 calcium-mediated signaling GO:0019722 9.89 HTR2B EDNRB EDN1
8 cartilage development GO:0051216 9.88 EDN1 BMPR1B BMP4
9 positive regulation of endothelial cell migration GO:0010595 9.88 EDN1 BMPR2 BMP4
10 positive regulation of endothelial cell proliferation GO:0001938 9.87 HTR2B BMPR2 BMP4 ACVRL1
11 positive regulation of osteoblast differentiation GO:0045669 9.86 BMPR2 BMPR1B BMP4 ACVR1
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.85 TNF EDN1 BMP4
13 positive regulation of MAP kinase activity GO:0043406 9.84 TNF HTR2B EDN1
14 neural crest cell migration GO:0001755 9.82 HTR2B EDNRB ACVR1
15 positive regulation of BMP signaling pathway GO:0030513 9.8 BMPR2 BMP4 ACVRL1
16 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.8 BMPR2 BMP4 ACVRL1 ACVR1
17 blood vessel remodeling GO:0001974 9.79 BMPR2 ACVRL1 ACE
18 mesoderm formation GO:0001707 9.79 BMPR2 BMP4 ACVR1
19 branching involved in blood vessel morphogenesis GO:0001569 9.78 EDNRA EDN1 ACVR1
20 dorsal/ventral pattern formation GO:0009953 9.78 EDN1 BMPR1B ACVRL1 ACVR1
21 outflow tract septum morphogenesis GO:0003148 9.77 BMPR2 BMP4 ACVR1
22 cGMP-mediated signaling GO:0019934 9.77 NPPB HTR2B EDNRB
23 cellular response to growth factor stimulus GO:0071363 9.77 BMPR2 BMPR1B BMP4 ACVRL1 ACVR1
24 activin receptor signaling pathway GO:0032924 9.76 BMPR2 ACVRL1 ACVR1
25 positive regulation of cartilage development GO:0061036 9.75 BMPR2 BMPR1B BMP4
26 BMP signaling pathway GO:0030509 9.73 SMAD9 BMPR2 BMPR1B BMP4 ACVRL1 ACVR1
27 atrioventricular valve morphogenesis GO:0003181 9.72 BMPR2 ACVR1
28 negative regulation of systemic arterial blood pressure GO:0003085 9.72 NPPB BMPR2
29 acute inflammatory response GO:0002526 9.72 HP ACVR1
30 lymphangiogenesis GO:0001946 9.72 BMPR2 ACVRL1
31 artery smooth muscle contraction GO:0014824 9.71 EDNRA EDN1
32 endocardial cushion development GO:0003197 9.71 BMPR2 BMP4
33 negative regulation of hormone secretion GO:0046888 9.71 EDN1 ADIPOQ
34 artery development GO:0060840 9.71 BMPR2 ACVRL1
35 negative regulation of DNA biosynthetic process GO:2000279 9.71 BMPR2 ADIPOQ ACVRL1
36 positive regulation of bone mineralization GO:0030501 9.71 BMPR2 BMPR1B BMP4 ACVR1
37 endothelial cell apoptotic process GO:0072577 9.7 TNF BMPR2
38 pharyngeal arch artery morphogenesis GO:0061626 9.7 BMPR2 BMP4
39 positive regulation of renal sodium excretion GO:0035815 9.7 NPPB EDNRB EDN1
40 retina vasculature development in camera-type eye GO:0061298 9.69 BMPR2 ACVRL1
41 regulation of glucose transmembrane transport GO:0010827 9.69 EDNRA EDN1
42 body fluid secretion GO:0007589 9.69 NPPB EDN1
43 positive regulation of urine volume GO:0035810 9.69 NPPB EDNRB EDN1
44 mitral valve morphogenesis GO:0003183 9.68 BMPR2 ACVR1
45 epithelial fluid transport GO:0042045 9.67 EDNRB EDN1
46 blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 9.67 BMP4 ACVRL1
47 BMP signaling pathway involved in heart development GO:0061312 9.66 BMP4 ACVR1
48 lymphatic endothelial cell differentiation GO:0060836 9.66 BMPR2 ACVRL1
49 negative regulation of chondrocyte proliferation GO:1902731 9.65 BMPR2 BMPR1B
50 endochondral bone morphogenesis GO:0060350 9.65 BMPR2 BMPR1B

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.76 TNF EDN1 BMP4 ADIPOQ
2 hormone activity GO:0005179 9.56 TTR NPPB EDN1 ADIPOQ
3 SMAD binding GO:0046332 9.54 BMPR1B ACVRL1 ACVR1
4 serotonin binding GO:0051378 9.48 SLC6A4 HTR2B
5 transforming growth factor beta-activated receptor activity GO:0005024 9.43 BMPR2 ACVRL1
6 BMP receptor activity GO:0098821 9.4 BMPR2 ACVRL1
7 activin receptor activity, type I GO:0016361 9.32 ACVRL1 ACVR1
8 endothelin receptor activity GO:0004962 9.16 EDNRB EDNRA
9 transforming growth factor beta receptor activity, type I GO:0005025 9.13 BMPR1B ACVRL1 ACVR1
10 transmembrane receptor protein serine/threonine kinase activity GO:0004675 8.92 BMPR2 BMPR1B ACVRL1 ACVR1
Sources

Sources for Chronic Pulmonary Heart Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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