MCID: CHR096
MIFTS: 38

Chronic Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Chronic Pulmonary Heart Disease

MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12326
ICD9CM 36 416.8

Summaries for Chronic Pulmonary Heart Disease

MalaCards based summary : Chronic Pulmonary Heart Disease is related to heart disease and pulmonary hypertension. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and Fluid shear stress and atherosclerosis. The drugs Iron and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and small intestine, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 heart disease 30.6 BMPR2 EDN1 HP TNF
2 pulmonary hypertension 28.5 BMPR2 EDN1 HTR2B PTGIR SLC6A4 SMAD9
3 chronic inflammatory demyelinating polyneuropathy 10.3 HP TTR
4 nutmeg liver 10.3 CP HP
5 melancholia 10.3 HP TNF
6 burns 10.3 TNF TTR
7 meconium aspiration syndrome 10.3 EDN1 TNF
8 glossitis 10.3 TNF TTR
9 nontuberculous mycobacterial lung disease 10.3 ADIPOQ TNF
10 idiopathic edema 10.3 ADIPOQ EDN1
11 nonalcoholic steatohepatitis 10.3 ADIPOQ TNF
12 raynaud disease 10.2 EDN1 PTGIR
13 endometrial disease 10.2 HP TNF
14 spondylarthropathy 10.2 HP TNF
15 eisenmenger syndrome 10.2 BMPR2 EDN1
16 granulocytopenia 10.2 CP TNF
17 apnea, obstructive sleep 10.2 ADIPOQ EDN1 TNF
18 sleep apnea 10.2 ADIPOQ EDN1 TNF
19 corticosteroid-binding globulin deficiency 10.2 CP HP
20 endometritis 10.2 HP TNF
21 eales disease 10.2 CP TNF
22 obstructive jaundice 10.1 EDN1 TNF TTR
23 chronic kidney failure 10.1 ADIPOQ EDN1 TTR
24 acquired metabolic disease 10.1 ADIPOQ TNF TTR
25 dysentery 10.1 HP TTR
26 heritable pulmonary arterial hypertension 10.1 BMPR2 SMAD9
27 hepatopulmonary syndrome 10.1 BMPR2 EDN1 TNF
28 complex regional pain syndrome 10.1 EDN1 TNF
29 portal hypertension 10.1 BMPR2 EDN1 TNF
30 microscopic colitis 10.1 SLC6A4 TNF
31 liver cirrhosis 10.1 ADIPOQ EDN1 TTR
32 connective tissue disease 10.1 BMPR2 EDN1 TNF
33 rheumatic fever 10.0 HP TNF
34 sexual disorder 10.0 EDN1 SLC6A4
35 anorexia nervosa 10.0 ADIPOQ SLC6A4 TTR
36 arteries, anomalies of 9.9 ADIPOQ BMPR2 EDN1 TNF
37 pulmonary hypertension, primary, 1 9.9 BMPR2 EDN1 SLC6A4
38 central nervous system disease 9.9 SLC6A4 TNF TTR
39 protein-energy malnutrition 9.9 CP HP TNF TTR
40 migraine with or without aura 1 9.8 HTR2B SLC6A4 TNF
41 vascular disease 9.8 ADIPOQ BMPR2 EDN1 HP TNF
42 liver disease 9.7 ADIPOQ CP TNF

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 35)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Cor Pulmonale Acute Cystitis
Anthracosis Anxiety
Asbestosis Bronchiectasis
Bronchitis Bronchopneumonia
Chronic Myocardial Ischemia Conn's Syndrome
Deficiency Anemia Dysthymic Disorder
Esophagitis Familial Atrial Fibrillation
Heart Disease Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Idiopathic Interstitial Pneumonia
Ischemic Heart Disease Mitral Valve Disease
Oral Candidiasis Osteoporosis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sleep Apnea
Status Asthmaticus Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:



Diseases related to Chronic Pulmonary Heart Disease

Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

27 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 HTR2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.6 SLC6A4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 HTR2B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.6 EDN1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 HTR2B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.6 HTR2B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.6 SLC6A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.6 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 HTR2B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.6 EDN1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 EDN1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.6 HTR2B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 EDN1 HTR2B SLC6A4
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 EDN1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 HTR2B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.6 SLC6A4

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.14 ADIPOQ BMPR2 CP EDN1 HP HTR2B
2 homeostasis/metabolism MP:0005376 10.02 ADIPOQ BMPR2 CP EDN1 G6PC3 HP
3 growth/size/body region MP:0005378 9.97 ADIPOQ BMPR2 EDN1 G6PC3 HTR2B SLC6A4
4 immune system MP:0005387 9.86 ADIPOQ BMPR2 CP G6PC3 HP PTGIR
5 mortality/aging MP:0010768 9.85 ADIPOQ BMPR2 EDN1 G6PC3 HP HTR2B
6 muscle MP:0005369 9.5 ADIPOQ BMPR2 EDN1 HTR2B SLC6A4 SMAD9
7 neoplasm MP:0002006 9.02 ADIPOQ HP PTGIR SMAD9 TNF

Drugs & Therapeutics for Chronic Pulmonary Heart Disease

Drugs for Chronic Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Phase 4 7439-89-6, 15438-31-0 27284 23925
2
Lactitol Investigational Phase 4 585-88-6, 585-86-4 493591
3 Ferric Compounds Phase 4
4 Nutrients Phase 4
5 Micronutrients Phase 4
6 Pharmaceutical Solutions Phase 4
7 Hematinics Phase 4
8 Trace Elements Phase 4
9
Metoprolol Approved, Investigational Phase 3 37350-58-6, 51384-51-1 4171
10 Peripheral Nervous System Agents Phase 3,Not Applicable
11 Neurotransmitter Agents Phase 3,Not Applicable
12 Antihypertensive Agents Phase 3,Not Applicable
13 Autonomic Agents Phase 3,Not Applicable
14 Adrenergic Agents Phase 3,Not Applicable
15 Anti-Arrhythmia Agents Phase 3
16 Adrenergic beta-1 Receptor Antagonists Phase 3
17 Adrenergic beta-Antagonists Phase 3
18 Adrenergic Antagonists Phase 3
19 Sympatholytics Phase 3
20 Vaccines Phase 1
21 Immunologic Factors Phase 1
22
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
23
tannic acid Approved Not Applicable 1401-55-4
24
Zinc Approved, Investigational Not Applicable 7440-66-6 32051
25
Exenatide Approved, Investigational Not Applicable 141758-74-9 15991534
26
Amlodipine Approved Not Applicable 88150-42-9 2162
27
Dobutamine Approved Not Applicable 34368-04-2 36811
28
Levodopa Approved 59-92-7 6047
29
Dopamine Approved 62-31-7, 51-61-6 681
30
Cabergoline Approved 81409-90-7 54746
31
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
32 Hypoglycemic Agents Not Applicable
33 Hormones Not Applicable
34 Anti-Obesity Agents Not Applicable
35 Hormone Antagonists Not Applicable
36 Incretins Not Applicable
37 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
38 Glucagon-Like Peptide 1 Not Applicable
39 Adrenergic Agonists Not Applicable
40 Sympathomimetics Not Applicable
41 Vasodilator Agents Not Applicable
42 Calcium, Dietary Not Applicable
43 Cardiotonic Agents Not Applicable
44 calcium channel blockers Not Applicable
45 Adrenergic beta-Agonists Not Applicable
46 Protective Agents Not Applicable
47 Dopamine agonists
48 Dopamine Agents
49 Vasoconstrictor Agents

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
2 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
3 Integrated Care Program for Chronic Obstructive Pulmonary Disease Completed NCT01045213 Phase 3
4 Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Active, not recruiting NCT02587351 Phase 3 Metoprolol succinate
5 Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Unknown status NCT03092648 Phase 1, Phase 2
6 Autologous Bronchial Basal Cell Transplantation for Treatment of COPD Recruiting NCT03188627 Phase 1, Phase 2
7 Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO Completed NCT02027129 Phase 1
8 A Phase I Randomized, Observer-Blinded, Dose-Ranging Study in Healthy Subjects 24 to <72 Months of Age Completed NCT02296463 Phase 1
9 Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD Not yet recruiting NCT03655795 Phase 1
10 Metabolic Changes in Patients With Chronic Cardiopulmonary Disease Unknown status NCT02550808
11 Effect of Normatec Pump for Relief of Leg Edema in Patients With Right Heart Failure Unknown status NCT00834145 Not Applicable
12 The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients Unknown status NCT02600039 Not Applicable
13 Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) Unknown status NCT01757522
14 Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale Completed NCT03243994 Not Applicable
15 The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale Completed NCT02976324 Not Applicable
16 Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease Completed NCT01554774
17 NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE) Completed NCT01633671
18 Impact of NaHCO3- on Exercise Hyperpnea Completed NCT03057535 Early Phase 1 Sodium Bicarbonate;Sodium Chloride
19 Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS) Completed NCT01553227 Not Applicable
20 World Trade Center (WTC) CHEST Completed NCT01466218
21 Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome Completed NCT01444898 Not Applicable Exenatide
22 Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF) Completed NCT01354613 Not Applicable Dobutamine;Amlodipine
23 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
24 An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation Recruiting NCT03021681 Not Applicable
25 Study of Renin-angiotensin System in Mechanically Ventilated Subjects Recruiting NCT03212690 Local standard of care
26 Acute CorPulmonale and ARDS Circulation Protection China Study China (ACPC) Not yet recruiting NCT03827863

Search NIH Clinical Center for Chronic Pulmonary Heart Disease

Genetic Tests for Chronic Pulmonary Heart Disease

Anatomical Context for Chronic Pulmonary Heart Disease

MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

42
Heart, Liver, Small Intestine, Endothelial, Lung, Kidney

Publications for Chronic Pulmonary Heart Disease

Articles related to Chronic Pulmonary Heart Disease:

(show all 24)
# Title Authors Year
1
Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. ( 27629759 )
2016
2
Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. ( 24142714 )
2013
3
Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. ( 24294047 )
2013
4
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21860655 )
2012
5
Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21711201 )
2011
6
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. ( 19080646 )
2008
7
[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. ( 12934401 )
2003
8
The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. ( 12435299 )
2002
9
Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. ( 11263275 )
2000
10
Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment. ( 7774397 )
1995
11
Effects of sustained ligustrazine on hemorrheology in patients with chronic pulmonary heart disease. ( 1453503 )
1992
12
Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease. ( 1816412 )
1991
13
[Noninvasive diagnosis of pulmonary hypertension in aged and elderly patients with chronic pulmonary heart disease]. ( 1857088 )
1991
14
Chronic pulmonary heart disease. ( 4557432 )
1972
15
The blood-gas exchange and the pH in chronic pulmonary heart disease. ( 13883689 )
1962
16
Respiratory acidosis in chronic pulmonary heart disease and the red cell pattern. ( 14025248 )
1962
17
PREDNISOLONE MAINTENANCE THERAPY IN CHRONIC PULMONARY HEART DISEASE. ( 18610137 )
1960
18
Respiratory acidosis in chronic pulmonary heart disease: pathogenesis, clinical features and management. ( 13623895 )
1959
19
The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. ( 13623896 )
1959
20
Pharmacological aspects of the pulmonary circulation in chronic pulmonary heart disease. ( 13848401 )
1959
21
[Chronic pulmonary heart disease]. ( 13231686 )
1954
22
Pneumoperitoneum in chronic pulmonary heart disease. ( 13084926 )
1953
23
Chronic pulmonary heart disease. ( 14935191 )
1952
24
Electrocardiographic appearances in acute and chronic pulmonary heart disease. ( 18880733 )
1948

Variations for Chronic Pulmonary Heart Disease

Expression for Chronic Pulmonary Heart Disease

Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.

Pathways for Chronic Pulmonary Heart Disease

GO Terms for Chronic Pulmonary Heart Disease

Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ADIPOQ BMPR2 CP EDN1 HP TNF

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.76 ADIPOQ EDN1 TNF TTR
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.67 ADIPOQ HTR2B TNF
3 response to hypoxia GO:0001666 9.65 ADIPOQ EDN1 SLC6A4
4 response to drug GO:0042493 9.62 ADIPOQ EDN1 HTR2B SLC6A4
5 positive regulation of JUN kinase activity GO:0043507 9.58 EDN1 TNF
6 cellular response to BMP stimulus GO:0071773 9.57 BMPR2 SMAD9
7 phosphatidylinositol 3-kinase signaling GO:0014065 9.56 EDN1 HTR2B
8 positive regulation of cytokine production GO:0001819 9.55 HTR2B TNF
9 positive regulation of cytokine secretion GO:0050715 9.54 HTR2B TNF
10 response to organic substance GO:0010033 9.54 HP SLC6A4 TNF
11 positive regulation of interleukin-8 production GO:0032757 9.52 ADIPOQ TNF
12 protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205 9.51 EDN1 HTR2B
13 negative regulation of DNA biosynthetic process GO:2000279 9.43 ADIPOQ BMPR2
14 negative regulation of hormone secretion GO:0046888 9.4 ADIPOQ EDN1
15 endothelial cell apoptotic process GO:0072577 9.26 BMPR2 TNF
16 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.16 ADIPOQ PTGIR
17 positive regulation of MAP kinase activity GO:0043406 9.13 EDN1 HTR2B TNF
18 vasoconstriction GO:0042310 8.8 EDN1 HTR2B SLC6A4

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 ADIPOQ EDN1 TNF
2 hormone activity GO:0005179 9.13 ADIPOQ EDN1 TTR
3 serotonin binding GO:0051378 8.62 HTR2B SLC6A4

Sources for Chronic Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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