MCID: CHR096
MIFTS: 36

Chronic Pulmonary Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Chronic Pulmonary Heart Disease

MalaCards integrated aliases for Chronic Pulmonary Heart Disease:

Name: Chronic Pulmonary Heart Disease 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:12326
ICD9CM 35 416.8

Summaries for Chronic Pulmonary Heart Disease

MalaCards based summary : Chronic Pulmonary Heart Disease is related to heart disease and pulmonary hypertension. An important gene associated with Chronic Pulmonary Heart Disease is EDN1 (Endothelin 1), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and DREAM Repression and Dynorphin Expression. The drugs Iron and Lactitol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Pulmonary Heart Disease

Diseases in the Acute Pulmonary Heart Disease family:

Chronic Pulmonary Heart Disease

Diseases related to Chronic Pulmonary Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 heart disease 30.7 BMPR2 EDN1 HP TNF
2 pulmonary hypertension 28.6 ACVRL1 BMPR2 EDN1 HTR2B PTGIR SLC6A4
3 nutmeg liver 10.2 CP HP
4 chronic inflammatory demyelinating polyneuropathy 10.2 HP TTR
5 burns 10.2 TNF TTR
6 chronic thromboembolic pulmonary hypertension 10.2 BMPR2 EDN1
7 melancholia 10.2 HP TNF
8 meconium aspiration syndrome 10.2 EDN1 TNF
9 glossitis 10.2 TNF TTR
10 endometrial disease 10.2 HP TNF
11 granulocytopenia 10.1 CP TNF
12 nontuberculous mycobacterial lung disease 10.1 ADIPOQ TNF
13 raynaud disease 10.1 EDN1 PTGIR
14 eisenmenger syndrome 10.1 BMPR2 EDN1
15 spondylarthropathy 10.1 HP TNF
16 nonalcoholic steatohepatitis 10.1 ADIPOQ TNF
17 idiopathic edema 10.1 ADIPOQ EDN1
18 corticosteroid-binding globulin deficiency 10.1 CP HP
19 eales disease 10.1 CP TNF
20 obstructive jaundice 10.1 EDN1 TNF TTR
21 pulmonary venoocclusive disease 10.1 ACVRL1 BMPR2
22 microscopic colitis 10.1 SLC6A4 TNF
23 apnea, obstructive sleep 10.1 ADIPOQ EDN1 TNF
24 endometritis 10.1 HP TNF
25 sleep apnea 10.1 ADIPOQ EDN1 TNF
26 portal hypertension 10.1 BMPR2 EDN1 TNF
27 chronic kidney failure 10.1 ADIPOQ EDN1 TTR
28 acquired metabolic disease 10.0 ADIPOQ TNF TTR
29 liver cirrhosis 10.0 ADIPOQ EDN1 TTR
30 mixed connective tissue disease 10.0 ACVRL1 BMPR2 TNF
31 protein-energy malnutrition 10.0 CP HP TNF TTR
32 central nervous system disease 10.0 SLC6A4 TNF TTR
33 anorexia nervosa 10.0 ADIPOQ SLC6A4 TTR
34 telangiectasis 10.0 ACVRL1 BMPR2
35 sexual disorder 10.0 EDN1 SLC6A4
36 dysentery 9.9 HP TTR
37 hepatopulmonary syndrome 9.9 ACVRL1 BMPR2 EDN1 TNF
38 connective tissue disease 9.9 ACVRL1 BMPR2 EDN1 TNF
39 migraine with or without aura 1 9.9 HTR2B SLC6A4 TNF
40 pulmonary hypertension, primary, 1 9.8 ACVRL1 BMPR2 EDN1 SLC6A4
41 heritable pulmonary arterial hypertension 9.8 ACVRL1 BMPR2 SMAD9
42 arteries, anomalies of 9.8 ACVRL1 ADIPOQ BMPR2 EDN1 TNF
43 vascular disease 9.6 ACVRL1 ADIPOQ BMPR2 EDN1 HP TNF

Comorbidity relations with Chronic Pulmonary Heart Disease via Phenotypic Disease Network (PDN): (show all 35)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Cor Pulmonale Acute Cystitis
Anthracosis Anxiety
Asbestosis Bronchiectasis
Bronchitis Bronchopneumonia
Chronic Myocardial Ischemia Conn's Syndrome
Deficiency Anemia Dysthymic Disorder
Esophagitis Familial Atrial Fibrillation
Heart Disease Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome
Hypothyroidism Idiopathic Interstitial Pneumonia
Ischemic Heart Disease Mitral Valve Disease
Oral Candidiasis Osteoporosis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Right Bundle Branch Block Sleep Apnea
Status Asthmaticus Tricuspid Valve Disease
Venous Insufficiency

Graphical network of the top 20 diseases related to Chronic Pulmonary Heart Disease:



Diseases related to Chronic Pulmonary Heart Disease

Symptoms & Phenotypes for Chronic Pulmonary Heart Disease

GenomeRNAi Phenotypes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.6 HTR2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.6 SLC6A4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.6 HTR2B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.6 EDN1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.6 HTR2B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.6 HTR2B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.6 SLC6A4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.6 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.6 HTR2B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.6 SLC6A4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.6 EDN1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 EDN1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.6 HTR2B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 EDN1 HTR2B SLC6A4
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 EDN1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.6 HTR2B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.6 SLC6A4

MGI Mouse Phenotypes related to Chronic Pulmonary Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 ACVRL1 ADIPOQ BMPR2 CP EDN1 HP
2 behavior/neurological MP:0005386 10.08 ACVRL1 ADIPOQ BMPR2 CP PTGIR SLC6A4
3 homeostasis/metabolism MP:0005376 10.07 ACVRL1 ADIPOQ BMPR2 CP EDN1 HP
4 mortality/aging MP:0010768 10.02 ACVRL1 ADIPOQ BMPR2 EDN1 HP HTR2B
5 growth/size/body region MP:0005378 10.01 ACVRL1 ADIPOQ BMPR2 EDN1 HTR2B SLC6A4
6 embryo MP:0005380 9.91 ACVRL1 BMPR2 EDN1 HTR2B SMAD9 TNF
7 muscle MP:0005369 9.86 ACVRL1 ADIPOQ BMPR2 EDN1 HTR2B SLC6A4
8 nervous system MP:0003631 9.56 ACVRL1 ADIPOQ BMPR2 CP EDN1 SLC6A4
9 neoplasm MP:0002006 9.55 ADIPOQ HP PTGIR SMAD9 TNF
10 renal/urinary system MP:0005367 9.1 ACVRL1 ADIPOQ BMPR2 EDN1 HP TTR

Drugs & Therapeutics for Chronic Pulmonary Heart Disease

Drugs for Chronic Pulmonary Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4 7439-89-6 23925
2
Lactitol Investigational Phase 4 585-86-4 3871
3 Ferric Compounds Phase 4
4 Trace Elements Phase 4
5 Micronutrients Phase 4
6 Hematinics Phase 4
7 Pharmaceutical Solutions Phase 4
8
Metoprolol Approved, Investigational Phase 3 37350-58-6, 51384-51-1 4171
9 Neurotransmitter Agents Phase 3,Not Applicable
10 Adrenergic Agents Phase 3,Not Applicable
11 Autonomic Agents Phase 3,Not Applicable
12 Antihypertensive Agents Phase 3,Not Applicable
13 Peripheral Nervous System Agents Phase 3,Not Applicable
14 Anti-Arrhythmia Agents Phase 3
15 Adrenergic beta-Antagonists Phase 3
16 Adrenergic beta-1 Receptor Antagonists Phase 3
17 Sympatholytics Phase 3
18 Adrenergic Antagonists Phase 3
19 Immunologic Factors Phase 1
20 Vaccines Phase 1
21 tannic acid Approved Not Applicable
22
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
23
Zinc Approved, Investigational Not Applicable 7440-66-6
24
Exenatide Approved, Investigational Not Applicable 141758-74-9 15991534
25
Dobutamine Approved Not Applicable 34368-04-2 36811
26
Amlodipine Approved Not Applicable 88150-42-9 2162
27
Cabergoline Approved 81409-90-7 54746
28
Dopamine Approved 51-61-6, 62-31-7 681
29
Levodopa Approved 59-92-7 6047
30 Hormone Antagonists Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
32 Incretins Not Applicable
33 Hypoglycemic Agents Not Applicable
34 Glucagon-Like Peptide 1 Not Applicable
35 Hormones Not Applicable
36 Sympathomimetics Not Applicable
37 Adrenergic beta-Agonists Not Applicable
38 Adrenergic Agonists Not Applicable
39 Calcium, Dietary Not Applicable
40 Cardiotonic Agents Not Applicable
41 Protective Agents Not Applicable
42 calcium channel blockers Not Applicable
43 Vasodilator Agents Not Applicable
44 Dopamine Agents
45 Dopamine agonists
46 Vasoconstrictor Agents

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Effect of Intravenous Iron (Ferinject®) on Exercise Capacity and Quality of Life of Stable COPD Patients Unknown status NCT02416778 Phase 4 Ferric carboxymaltose, Ferinject® 50mg Iron/ml Solution for Injection / Infusion
2 Acute Effect of Pulmonary Desufflation on Cardiac Performance in COPD Patients Completed NCT01996124 Phase 4 Indacaterol Fumarate;Placebo
3 Integrated Care Program for Chronic Obstructive Pulmonary Disease Completed NCT01045213 Phase 3
4 Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease Recruiting NCT02587351 Phase 3 Metoprolol succinate
5 Autologous Bronchial Basal Cell Transplantation for Treatment of COPD Recruiting NCT03188627 Phase 1, Phase 2
6 Autologous Bronchial Basal Cells Transplantation for Treatment of Chronic Obstructive Pulmonary Disease (COPD) Recruiting NCT03092648 Phase 1, Phase 2
7 Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO Completed NCT02027129 Phase 1
8 A Phase I Randomized, Observer-Blinded, Dose-Ranging Study in Healthy Subjects 24 to <72 Months of Age Completed NCT02296463 Phase 1
9 Autologous Transplantation of Bronchial Basal Cells for Treatment of COPD Not yet recruiting NCT03655795 Phase 1
10 Metabolic Changes in Patients With Chronic Cardiopulmonary Disease Unknown status NCT02550808
11 Effect of Normatec Pump for Relief of Leg Edema in Patients With Right Heart Failure Unknown status NCT00834145 Not Applicable
12 The Short-term Effect of ELTGOL on Pulmonary Ventilation Valued Through Electrical Impedance Tomography in Cystic Fibrosis Patients Unknown status NCT02600039 Not Applicable
13 Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) Unknown status NCT01757522
14 Small Intestinal Absorption in Patients With Chronic Obstructive Pulmonary Disease and Cor Pulmonale Completed NCT03243994 Not Applicable
15 The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale Completed NCT02976324 Not Applicable
16 Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease Completed NCT01554774
17 NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE) Completed NCT01633671
18 Impact of NaHCO3- on Exercise Hyperpnea Completed NCT03057535 Early Phase 1 Sodium Bicarbonate;Sodium Chloride
19 Treatment for Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypoventilation Syndrome (OHS) Completed NCT01553227 Not Applicable
20 World Trade Center (WTC) CHEST Completed NCT01466218
21 Effects of Exenatide on Overweight Adolescents With Prader-Willi Syndrome Completed NCT01444898 Not Applicable Exenatide
22 Reduced Contractile Reserve: a Therapeutic Target in Heart Failure With Preserved Ejection Fraction(HFpEF) Completed NCT01354613 Not Applicable Dobutamine;Amlodipine
23 The Association Between Dopamine Agonists and Cardiac Valvulopathy, Fibrosis and Other Cardiopulmonary Events Completed NCT01052948
24 An Exploratory Study on the Treatment of Chronic Obstructive Pulmonary Disease With Autologous Bronchial Basal Cell Transplantation Recruiting NCT03021681 Not Applicable
25 Study of Renin-angiotensin System in Mechanically Ventilated Subjects Recruiting NCT03212690 Local standard of care

Search NIH Clinical Center for Chronic Pulmonary Heart Disease

Genetic Tests for Chronic Pulmonary Heart Disease

Anatomical Context for Chronic Pulmonary Heart Disease

MalaCards organs/tissues related to Chronic Pulmonary Heart Disease:

41
Heart, Endothelial, Lung, Kidney, Liver

Publications for Chronic Pulmonary Heart Disease

Articles related to Chronic Pulmonary Heart Disease:

(show all 25)
# Title Authors Year
1
Evaluation of Right Ventricular Systolic Function in Patients With Chronic Pulmonary Heart Disease by 2-Dimensional Speckle-Tracking Echocardiography. ( 27629759 )
2016
2
Atorvastatin improves endothelial progenitor cell function and reduces pulmonary hypertension in patients with chronic pulmonary heart disease. ( 24294047 )
2013
3
Role of voltage-gated potassium channels in pathogenesis of chronic pulmonary heart disease. ( 24142714 )
2013
4
Ligustrazine injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21860655 )
2012
5
Shenmai injection for chronic pulmonary heart disease: a systematic review and meta-analysis. ( 21711201 )
2011
6
[Serum adiponectin level in patients of chronic pulmonary heart disease with cardiac failure]. ( 19080646 )
2008
7
Hospital Stays Involving Chronic Pulmonary Heart Disease, 2005: Statistical Brief #43 ( 21755628 )
2006
8
[Changes of NO and ET-1 in the blood of patients with chronic pulmonary heart disease]. ( 12934401 )
2003
9
The inhibition of pulmonary vessel remodeling by carbon monoxide system in rats with chronic pulmonary heart disease. ( 12435299 )
2002
10
Effects of huang qi wu wu decoction on plasma proteins in 70 cases of chronic pulmonary heart disease. ( 11263275 )
2000
11
Platelet activation in patients with chronic pulmonary heart disease. Effect of dipyridamole treatment. ( 7774397 )
1995
12
Effects of sustained ligustrazine on hemorrheology in patients with chronic pulmonary heart disease. ( 1453503 )
1992
13
Effects of ligustrazine controlled release capsule in chronic pulmonary heart disease. ( 1816412 )
1991
14
[Noninvasive diagnosis of pulmonary hypertension in aged and elderly patients with chronic pulmonary heart disease]. ( 1857088 )
1991
15
Chronic pulmonary heart disease. ( 4557432 )
1972
16
Respiratory acidosis in chronic pulmonary heart disease and the red cell pattern. ( 14025248 )
1962
17
The blood-gas exchange and the pH in chronic pulmonary heart disease. ( 13883689 )
1962
18
PREDNISOLONE MAINTENANCE THERAPY IN CHRONIC PULMONARY HEART DISEASE. ( 18610137 )
1960
19
Pharmacological aspects of the pulmonary circulation in chronic pulmonary heart disease. ( 13848401 )
1959
20
The mechanisms of chronic pulmonary heart disease (cor pulmonale), with and without arterial hypoxemia. ( 13623896 )
1959
21
Respiratory acidosis in chronic pulmonary heart disease: pathogenesis, clinical features and management. ( 13623895 )
1959
22
[Chronic pulmonary heart disease]. ( 13231686 )
1954
23
Pneumoperitoneum in chronic pulmonary heart disease. ( 13084926 )
1953
24
Chronic pulmonary heart disease. ( 14935191 )
1952
25
Electrocardiographic appearances in acute and chronic pulmonary heart disease. ( 18880733 )
1948

Variations for Chronic Pulmonary Heart Disease

Expression for Chronic Pulmonary Heart Disease

Search GEO for disease gene expression data for Chronic Pulmonary Heart Disease.

Pathways for Chronic Pulmonary Heart Disease

GO Terms for Chronic Pulmonary Heart Disease

Cellular components related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.46 ACVRL1 ADIPOQ BMPR2 TNF
2 integral component of plasma membrane GO:0005887 9.43 ACVRL1 BMPR2 HTR2B PTGIR SLC6A4 TNF
3 extracellular space GO:0005615 9.17 ADIPOQ BMPR2 CP EDN1 HP TNF

Biological processes related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.9 ADIPOQ EDN1 TNF TTR
2 response to drug GO:0042493 9.84 ADIPOQ EDN1 HTR2B SLC6A4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.78 ADIPOQ HTR2B TNF
4 transforming growth factor beta receptor signaling pathway GO:0007179 9.74 ACVRL1 BMPR2 SMAD9
5 response to organic substance GO:0010033 9.72 HP SLC6A4 TNF
6 BMP signaling pathway GO:0030509 9.7 ACVRL1 BMPR2 SMAD9
7 negative regulation of endothelial cell proliferation GO:0001937 9.65 ACVRL1 TNF
8 positive regulation of BMP signaling pathway GO:0030513 9.65 ACVRL1 BMPR2
9 phosphatidylinositol 3-kinase signaling GO:0014065 9.64 EDN1 HTR2B
10 blood vessel remodeling GO:0001974 9.64 ACVRL1 BMPR2
11 blood vessel morphogenesis GO:0048514 9.63 ACVRL1 EDN1
12 positive regulation of cytokine production GO:0001819 9.63 HTR2B TNF
13 positive regulation of cytokine secretion GO:0050715 9.62 HTR2B TNF
14 positive regulation of interleukin-8 production GO:0032757 9.62 ADIPOQ TNF
15 protein kinase C-activating G protein-coupled receptor signaling pathway GO:0007205 9.61 EDN1 HTR2B
16 positive regulation of endothelial cell proliferation GO:0001938 9.61 ACVRL1 BMPR2 HTR2B
17 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.59 ACVRL1 BMPR2
18 activin receptor signaling pathway GO:0032924 9.58 ACVRL1 BMPR2
19 lymphangiogenesis GO:0001946 9.58 ACVRL1 BMPR2
20 negative regulation of hormone secretion GO:0046888 9.56 ADIPOQ EDN1
21 response to hypoxia GO:0001666 9.56 ACVRL1 ADIPOQ EDN1 SLC6A4
22 positive regulation of MAP kinase activity GO:0043406 9.54 EDN1 HTR2B TNF
23 artery development GO:0060840 9.51 ACVRL1 BMPR2
24 endothelial cell apoptotic process GO:0072577 9.49 BMPR2 TNF
25 negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642 9.48 ADIPOQ PTGIR
26 retina vasculature development in camera-type eye GO:0061298 9.46 ACVRL1 BMPR2
27 lymphatic endothelial cell differentiation GO:0060836 9.4 ACVRL1 BMPR2
28 cellular response to BMP stimulus GO:0071773 9.33 ACVRL1 BMPR2 SMAD9
29 venous blood vessel development GO:0060841 9.32 ACVRL1 BMPR2
30 vasoconstriction GO:0042310 9.13 EDN1 HTR2B SLC6A4
31 negative regulation of DNA biosynthetic process GO:2000279 8.8 ACVRL1 ADIPOQ BMPR2

Molecular functions related to Chronic Pulmonary Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.54 ADIPOQ EDN1 TNF
2 hormone activity GO:0005179 9.43 ADIPOQ EDN1 TTR
3 transforming growth factor beta-activated receptor activity GO:0005024 9.32 ACVRL1 BMPR2
4 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVRL1 BMPR2
5 serotonin binding GO:0051378 8.96 HTR2B SLC6A4
6 BMP receptor activity GO:0098821 8.62 ACVRL1 BMPR2

Sources for Chronic Pulmonary Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....