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MCID: CHR097
MIFTS: 32

Chronic Purulent Otitis Media

Categories: Ear diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Chronic Purulent Otitis Media

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MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 74
Chronic Suppurative Otitis Media 12

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:14247
ICD9CM 36 382.3
NCIt 51 C128386
SNOMED-CT 69 38394007
ICD10 34 H66.3
UMLS 74 C0271454
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Summaries for Chronic Purulent Otitis Media

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Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to suppurative otitis media and chronic atticoantral disease. An important gene associated with Chronic Purulent Otitis Media is HSF4 (Heat Shock Transcription Factor 4). The drugs Dexamethasone and Acetylcysteine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes.

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Related Diseases for Chronic Purulent Otitis Media

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Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 31.9 HSF4 WIPF1
2 chronic atticoantral disease 11.5
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
4 otitis media 10.6
5 sensorineural hearing loss 10.5
6 meningitis 10.4
7 mastoiditis 10.3
8 lateral sinus thrombosis 10.3
9 cleft palate, isolated 10.3
10 allergic rhinitis 10.3
11 inflammatory myofibroblastic tumor 10.3
12 facial paralysis 10.3
13 rhinitis 10.3
14 otitis externa 10.3
15 perilymphatic fistula 10.3
16 thrombosis 10.1
17 cholesteatoma of middle ear 10.1
18 focal labyrinthitis 10.1
19 labyrinthitis 10.1
20 anxiety 10.1
21 aphasia 10.1
22 abducens nerve disease 10.1
23 myiasis 10.1
24 non-suppurative otitis media 10.1
25 subdural empyema 10.1
26 tympanosclerosis 10.1
27 otosclerosis 10.1
28 serous labyrinthitis 10.1
29 dermatitis 10.1
30 rhabdomyosarcoma 10.1
31 pleural empyema 10.1
32 chickenpox 10.1
33 fasciitis 10.1
34 necrotizing fasciitis 10.1
35 glioma 10.1
36 nasopharyngeal carcinoma 10.1
37 depression 10.1

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media
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Symptoms & Phenotypes for Chronic Purulent Otitis Media

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Drugs & Therapeutics for Chronic Purulent Otitis Media

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Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
5 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
6 Topoisomerase Inhibitors Phase 4,Phase 1
7 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
9 Pharmaceutical Solutions Phase 4
10 Antineoplastic Agents, Hormonal Phase 4
11 Free Radical Scavengers Phase 4
12 Hormones Phase 4,Not Applicable
13 N-monoacetylcystine Phase 4
14 Hormone Antagonists Phase 4
15 Antidotes Phase 4
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Antiemetics Phase 4
19 Autonomic Agents Phase 4
20 Respiratory System Agents Phase 4
21 Gastrointestinal Agents Phase 4
22 HIV Protease Inhibitors Phase 4
23 glucocorticoids Phase 4
24 Antiviral Agents Phase 4
25 Antioxidants Phase 4
26 Peripheral Nervous System Agents Phase 4,Not Applicable
27 Protective Agents Phase 4
28 BB 1101 Phase 4
29
protease inhibitors Phase 4
30 Expectorants Phase 4
31 Anti-Inflammatory Agents Phase 4
32
carbamide peroxide Approved Phase 1 124-43-6
33 Pazufloxacin Investigational Phase 1 127045-41-4
34 Nucleic Acid Synthesis Inhibitors Phase 1
35 Antitubercular Agents Phase 1
36 Fluoroquinolones Phase 1
37 Anti-Infective Agents, Local Phase 1
38
leucovorin Approved Not Applicable 58-05-9 143 6006
39
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
40
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
41
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
42 Folate Not Applicable
43 Anti-Infective Agents, Urinary Not Applicable
44 Folic Acid Antagonists Not Applicable
45 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
46 Vitamin B9 Not Applicable
47 Antimalarials Not Applicable
48 Vitamin B Complex Not Applicable
49 Antiparasitic Agents Not Applicable
50 Renal Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
5 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Unknown status NCT02716376 Not Applicable
6 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
7 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
8 Endoscopic Tympanoplasty: Single Versus Double Flap Technique Completed NCT03922295 Not Applicable
9 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
10 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
11 Preemptive Pregabalin in Myringoplasty Withdrawn NCT03603626 Not Applicable Pregabalin 150mg;Placebo oral capsule

Search NIH Clinical Center for Chronic Purulent Otitis Media

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Genetic Tests for Chronic Purulent Otitis Media

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Anatomical Context for Chronic Purulent Otitis Media

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MalaCards organs/tissues related to Chronic Purulent Otitis Media:

42
Bone, Brain, Testes, Temporal Lobe, Colon, Neutrophil, T Cells
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Publications for Chronic Purulent Otitis Media

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Articles related to Chronic Purulent Otitis Media:

(show top 50) (show all 521)
# Title Authors Year
1
Association of hearing loss with depression, anxiety and stress in patients suffering from Chronic Suppurative Otitis Media. ( 31086542 )
2019
2
The Role of Routine Culture in the Treatment of Chronic Suppurative Otitis Media: Implications for the Standard of Care in Rural Areas of South Africa. ( 30626120 )
2019
3
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
4
Correlation of Eustachian Tube Dysfunction with Results of Tympanoplasty in Mucosal Type of Chronic Suppurative Otitis Media. ( 30906705 )
2019
5
Does The Type of Ossicular Chain Lesion Affect Outcomes in Chronic Suppurative Otitis Media Without Cholesteatoma? ( 30924779 )
2019
6
Is Routine Use of High Resolution Computerized Tomography of Temporal Bone in Patients of Atticoantral Chronic Suppurative Otitis Media without Intracranial Complications Justified? ( 29456948 )
2018
7
To Evaluate and Compare the Result of Ossiculoplasty Using Different Types of Graft Materials and Prosthesis in Cases of Ossicular Discontinuity in Chronic Suppurative Otitis Media Cases. ( 29456937 )
2018
8
Efficacy of Boric Acid as a Treatment of Choice for Chronic Suppurative Otitis Media and Its Ototoxicity. ( 29383205 )
2018
9
Efficacy of Empirical Therapy With Combined Ciprofloxacin Versus Topical Drops Alone in Patients With Tubotympanic Chronic Suppurative Otitis Media: A Randomized Double-Blind Controlled Trial. ( 29348711 )
2018
10
Risk factors of sensorineural hearing loss in patients with unilateral safe chronic suppurative otitis media. ( 29331307 )
2018
11
Mycology of chronic suppurative otitis media-cholesteatoma disease: An evaluative study. ( 29306568 )
2018
12
Effectiveness of Type I Tympanoplasty in Wet and Dry Ear in Safe Chronic Suppurative Otitis Media. ( 30211083 )
2018
13
Causes of Delayed Care Seeking for Chronic Suppurative Otitis Media at a Rwandan Tertiary Hospital. ( 30057615 )
2018
14
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. ( 30049178 )
2018
15
Implementation and results of a surgical training programme for chronic suppurative otitis media in Cambodia. ( 29998817 )
2018
16
The Role of Mannose-Binding Lectin Serum Level in Tubotympanic Chronic Suppurative Otitis Media. ( 29951099 )
2018
17
Development of an ear cap in chronic suppurative otitis media using additive manufacturing and TRIZ. ( 29916767 )
2018
18
Aerobic bacteria associated with chronic suppurative otitis media in Angola. ( 29720274 )
2018
19
Shewanella algae in a chronic suppurative otitis media patient with cholesteatoma. ( 29681564 )
2018
20
Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. ( 30555142 )
2018
21
Comment to Empirical Therapy for Chronic Suppurative Otitis Media. ( 30479492 )
2018
22
Development and Administration of Chronic Suppurative Otitis Media Questionnaire-12 (COMQ-12) and Chronic Otitis Media Outcome Test-15 (COMOT-15) in Kannada. ( 29619096 )
2018
23
A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. ( 29151379 )
2018
24
Management of Chronic Suppurative Otitis Media and Otosclerosis in Developing Countries. ( 29525390 )
2018
25
Surveillance of bacteria Pseudomonas aeruginosa and MRSA associated with chronic suppurative otitis media. ( 27177975 )
2017
26
Recurrent otorrhea in chronic suppurative otitis media: is biofilm the missing link? ( 28466356 )
2017
27
Sensorineural hearing loss in patients with chronic suppurative otitis media: Is there a significant correlation? ( 28465813 )
2017
28
Quality of life measurements for patients with chronic suppurative otitis media: Italian adaptation of "Chronic Ear Survey". ( 28374871 )
2017
29
Impact of Chronic Suppurative Otitis Media in Pediatric Cochlear Implant Recipients-Insight into the Challenges from a Tertiary Referral Center in UK. ( 28333779 )
2017
30
High-frequency conductive hearing loss as a diagnostic test for incomplete ossicular discontinuity in non-cholesteatomatous chronic suppurative otitis media. ( 29267386 )
2017
31
Prevalence of paediatric chronic suppurative otitis media and hearing impairment in rural Malawi: A cross-sectional survey. ( 29267304 )
2017
32
Day-case management of chronic suppurative otitis media with cholesteatoma with canal wall down technique surgery: long-term follow-up. ( 29071059 )
2017
33
Central Nervous System Inflammatory Myofibroblastic Tumor Masquerading as Chronic Suppurative Otitis Media. ( 28904584 )
2017
34
Gradenigo's Syndrome in a Patient with Chronic Suppurative Otitis Media, Petrous Apicitis, and Meningitis. ( 28955030 )
2017
35
Comparative Evaluation of Tympanoplasty with or Without Mastoidectomy in Treatment of Chronic Suppurative Otitis Media Tubotympanic Type. ( 28607885 )
2017
36
Microbiology of Chronic Suppurative Otitis Media in a Tertiary Care Hospital in Bangladesh. ( 28919615 )
2017
37
Fluoroquinolone-Resistant Alcaligenes faecalis Related to Chronic Suppurative Otitis Media, Angola. ( 28930018 )
2017
38
Predictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania. ( 26766925 )
2016
39
Do tissue spears used to clear ear canal pus improve hearing? A case series study of hearing in remote Australian Aboriginal children with chronic suppurative otitis media before and after dry mopping with tissue spears. ( 26685792 )
2016
40
Mitochondrial DNA deletions in patients with chronic suppurative otitis media. ( 26620342 )
2016
41
The changing epidemiological and complications profile of chronic suppurative otitis media in a developing country after two decades. ( 26611685 )
2016
42
Why are ototopical aminoglycosides still first-line therapy for chronic suppurative otitis media? A systematic review and discussion of aminoglycosides versus quinolones. ( 26584651 )
2016
43
Knowledge, attitudes, beliefs and practices related to chronic suppurative otitis media and hearing impairment in Pokhara, Nepal. ( 26567594 )
2016
44
A systematic review of patient-reported outcome measures for chronic suppurative otitis media. ( 26371616 )
2016
45
Characterization of the T-cell subpopulations in the granulation tissues of chronic suppurative otitis media. ( 27313854 )
2016
46
Etiological factors associated with chronic suppurative otitis media in a population of Han adults in China. ( 27206699 )
2016
47
Prevalence and associated factors of chronic suppurative otitis media: Data from the Korea National Health and Nutrition Examination Survey, 2009-2012. ( 27076099 )
2016
48
The evaluation of eustachian tube paratubal structures using magnetic resonance imaging in patients with chronic suppurative otitis media. ( 27008280 )
2016
49
Chronic suppurative otitis media, middle ear pathology and corresponding hearing loss in a cohort of Greenlandic children. ( 26968069 )
2016
50
Evaluation of Role of Mastoid Surgery in the Management of Safe Chronic Suppurative Otitis Media. ( 27833868 )
2016
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Variations for Chronic Purulent Otitis Media

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Expression for Chronic Purulent Otitis Media

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Search GEO for disease gene expression data for Chronic Purulent Otitis Media.
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Pathways for Chronic Purulent Otitis Media

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GO Terms for Chronic Purulent Otitis Media

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Sources for Chronic Purulent Otitis Media

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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