MCID: CHR097
MIFTS: 29

Chronic Purulent Otitis Media

Categories: Ear diseases

Aliases & Classifications for Chronic Purulent Otitis Media

MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 73
Chronic Suppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14247
ICD10 33 H66.3
ICD9CM 35 382.3
NCIt 50 C128386
SNOMED-CT 68 38394007
UMLS 73 C0271454

Summaries for Chronic Purulent Otitis Media

Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to suppurative otitis media and chronic atticoantral disease. An important gene associated with Chronic Purulent Otitis Media is TLR9 (Toll Like Receptor 9). The drugs Dexamethasone acetate and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and colon.

Related Diseases for Chronic Purulent Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 suppurative otitis media 31.8 HSF4 TLR9 WIPF1
2 chronic atticoantral disease 11.4
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
4 otitis media 10.6
5 sensorineural hearing loss 10.5
6 meningitis 10.4
7 mastoiditis 10.3
8 lateral sinus thrombosis 10.3
9 cleft palate, isolated 10.2
10 allergic rhinitis 10.2
11 inflammatory myofibroblastic tumor 10.2
12 facial paralysis 10.2
13 rhinitis 10.2
14 otitis externa 10.2
15 perilymphatic fistula 10.2
16 thrombosis 10.1
17 focal labyrinthitis 10.1
18 labyrinthitis 10.1
19 nasopharyngeal carcinoma 10.1
20 aphasia 10.1
21 abducens nerve disease 10.1
22 cholesteatoma of middle ear 10.1
23 myiasis 10.1
24 subdural empyema 10.1
25 tympanosclerosis 10.1
26 otosclerosis 10.1
27 serous labyrinthitis 10.1
28 dermatitis 10.1
29 rhabdomyosarcoma 10.1
30 fasciitis 10.1
31 necrotizing fasciitis 10.1
32 glioma 10.1

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media

Symptoms & Phenotypes for Chronic Purulent Otitis Media

Drugs & Therapeutics for Chronic Purulent Otitis Media

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
6 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
7 Topoisomerase Inhibitors Phase 4,Phase 1
8 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
9 Expectorants Phase 4
10 Gastrointestinal Agents Phase 4
11 Hormones Phase 4
12 Antineoplastic Agents, Hormonal Phase 4
13 Protective Agents Phase 4
14 Anti-Inflammatory Agents Phase 4
15 Pharmaceutical Solutions Phase 4
16 Antiemetics Phase 4
17 Free Radical Scavengers Phase 4
18 HIV Protease Inhibitors Phase 4
19 N-monoacetylcystine Phase 4
20 Antioxidants Phase 4
21 Antiviral Agents Phase 4
22 Hormone Antagonists Phase 4
23
protease inhibitors Phase 4
24 Respiratory System Agents Phase 4
25 BB 1101 Phase 4
26 Peripheral Nervous System Agents Phase 4,Not Applicable
27 glucocorticoids Phase 4
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
29 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
30 Antidotes Phase 4
31 Autonomic Agents Phase 4
32 Pazufloxacin Investigational Phase 1 127045-41-4
33 Antitubercular Agents Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35 Fluoroquinolones Phase 1
36
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
37
leucovorin Approved Not Applicable 58-05-9 6006 143
38
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
39
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
40 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
41 Folic Acid Antagonists Not Applicable
42 Vitamin B Complex Not Applicable
43 Antimalarials Not Applicable
44 Folate Not Applicable
45 Antiprotozoal Agents Not Applicable
46 Renal Agents Not Applicable
47 Anti-Infective Agents, Urinary Not Applicable
48 Vitamin B9 Not Applicable
49 Antiparasitic Agents Not Applicable
50 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
5 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
6 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
7 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
8 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
9 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable
10 Preemptive Pregabalin in Myringoplasty Withdrawn NCT03603626 Not Applicable Pregabalin 150mg;Placebo oral capsule

Search NIH Clinical Center for Chronic Purulent Otitis Media

Genetic Tests for Chronic Purulent Otitis Media

Anatomical Context for Chronic Purulent Otitis Media

MalaCards organs/tissues related to Chronic Purulent Otitis Media:

41
Brain, Bone, Colon

Publications for Chronic Purulent Otitis Media

Articles related to Chronic Purulent Otitis Media:

(show all 50)
# Title Authors Year
1
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. ( 30531639 )
2019
2
Implementation and results of a surgical training programme for chronic suppurative otitis media in Cambodia. ( 29998817 )
2018
3
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. ( 30049178 )
2018
4
Causes of Delayed Care Seeking for Chronic Suppurative Otitis Media at a Rwandan Tertiary Hospital. ( 30057615 )
2018
5
Effectiveness of Type I Tympanoplasty in Wet and Dry Ear in Safe Chronic Suppurative Otitis Media. ( 30211083 )
2018
6
Comment to Empirical Therapy for Chronic Suppurative Otitis Media. ( 30479492 )
2018
7
Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. ( 30555142 )
2018
8
Is Routine Use of High Resolution Computerized Tomography of Temporal Bone in Patients of Atticoantral Chronic Suppurative Otitis Media without Intracranial Complications Justified? ( 29456948 )
2018
9
Mitochondrial DNA deletions in patients with chronic suppurative otitis media. ( 26620342 )
2016
10
Correlation of Bacterial Isolates from Middle Ear and Nasopharynx in Patients with Chronic Suppurative Otitis Media in Ilorin, Nigeria. ( 28239265 )
2015
11
Attenuated TLRs in middle ear mucosa contributes to susceptibility of chronic suppurative otitis media. ( 24882571 )
2014
12
Rarely reported ocular complications following surgery to correct chronic suppurative otitis media. ( 21626122 )
2012
13
Nasal Colonization of Methicillin-Resistant Staphylococcus aureus in Patients with Chronic Suppurative Otitis Media. ( 24653875 )
2012
14
A case-control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children. ( 21540875 )
2011
15
Complications of chronic suppurative otitis media and their management. ( 17277619 )
2007
16
Chronic suppurative otitis media: a review. ( 16198004 )
2006
17
Chronic suppurative otitis media with intracranial complication. ( 22266447 )
2006
18
Role of glucocorticoids in ototopical antibiotic-steroid preparations in the treatment of chronic suppurative otitis media. ( 15847949 )
2005
19
Cost-utility analysis of tympanomastoidectomy for adults with chronic suppurative otitis media. ( 16143180 )
2005
20
Retraction pockets in chronic suppurative otitis media- our experience. ( 23119953 )
2003
21
Ceftazidime for outpatient parenteral antibiotic therapy (OPAT) of chronic suppurative otitis media due to Pseudomonas aeruginosa. ( 10768520 )
2000
22
Facial nerve paralysis in chronic suppurative otitis media: Ankara Numune Hospital experience. ( 9673730 )
1998
23
Atelectasis and chronic suppurative otitis media. ( 9170708 )
1997
24
Multicenter study of the efficacy and safety of oral ciprofloxacin in the treatment of chronic suppurative otitis media in adults. The French Study Group. ( 9230329 )
1997
25
Anaerobes and fungi in chronic suppurative otitis media. ( 9270427 )
1997
26
Burkholderia (Pseudomonas) cepacia as a cause of brain abscesses secondary to chronic suppurative otitis media. ( 8605906 )
1995
27
Chronic purulent otitis media: the prevailing pathology form among northern nationalities. ( 1365253 )
1991
28
Ambulatory intravenous therapy for chronic suppurative otitis media. ( 2066849 )
1991
29
Randomised comparative efficacy of clindamycin, metronidazole, and lincomycin, plus gentamicin in chronic suppurative otitis media. ( 2268574 )
1990
30
Ceftazidime in the treatment of chronic suppurative otitis media in children. ( 6352646 )
1983
31
Study of diffusion of cefuroxime into middle ear effusions of patients with chronic purulent otitis media. ( 7142073 )
1982
32
Bacteriological study of chronic suppurative otitis media. ( 7229399 )
1980
33
Chronic suppurative otitis media and the pathologic labyrinthine fistula. ( 5450297 )
1970
34
Bacteriology of chronic suppurative otitis media. ( 5849578 )
1965
35
Chronic suppurative otitis media and allergy in adults. ( 14454293 )
1962
36
The treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 18143038 )
1949
37
Modified technic of plastic procedure in radical mastoidectomy; report of results in a case of circumscribed labyrinthitis and periphlebitis of the lateral sinus in the course of chronic purulent otitis media with cholesteatoma. ( 15394995 )
1949
38
Chronic purulent otitis media. ( 18919212 )
1947
39
Chronic purulent otitis media. ( 20260367 )
1947
40
A different treatment of chronic purulent otitis media; deep lavage, aeration and application of gold foil membrane bearing ointment of scarlet red. ( 18896820 )
1947
41
The treatment of chronic suppurative otitis media. ( 20294766 )
1947
42
Treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 20993474 )
1946
43
Treatment of chronic suppurative otitis media with penicillin. ( 21012408 )
1945
44
Complete Stapes thrown off during Chronic Suppurative Otitis Media, ? Tuberculosis. ( 19989802 )
1934
45
Chronic Purulent Otitis Media: Its Treatment with Iodin Powder (Sulzberger). ( 18742568 )
1933
46
Chronic Suppurative Otitis Media with Cholesteatoma: Acute Labyrinthitis and Meningitis. Recovery after Radical Mastoid Operation. ( 19988896 )
1932
47
Temporo-sphenoidal Abscess following Chronic Suppurative Otitis Media; Operation; Recovery. ( 19976252 )
1912
48
Indications for Operation in Chronic Purulent Otitis Media. ( 18734787 )
1909
49
Primary Epithelioma (?) of Tympanum following Chronic Suppurative Otitis media. ( 19973285 )
1908
50
Remarks upon the Operative Treatment of Infective Thrombosis of the Sigmoid Sinus Following Chronic Purulent Otitis Media: Record of a Case Successfully Treated. ( 30435965 )
1899

Variations for Chronic Purulent Otitis Media

Expression for Chronic Purulent Otitis Media

Search GEO for disease gene expression data for Chronic Purulent Otitis Media.

Pathways for Chronic Purulent Otitis Media

GO Terms for Chronic Purulent Otitis Media

Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 8.92 HINT1 HSF4 NR2F1 RUNX1T1

Sources for Chronic Purulent Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....