MCID: CHR097
MIFTS: 24

Chronic Purulent Otitis Media

Categories: Ear diseases

Aliases & Classifications for Chronic Purulent Otitis Media

MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 73
Chronic Suppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14247
ICD10 33 H66.3
ICD9CM 35 382.3
UMLS 73 C0271454

Summaries for Chronic Purulent Otitis Media

Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to chronic atticoantral disease and otitis media. An important gene associated with Chronic Purulent Otitis Media is TLR9 (Toll Like Receptor 9). The drugs Acetylcysteine and Ciprofloxacin have been mentioned in the context of this disorder. Related phenotype is digestive/alimentary.

Related Diseases for Chronic Purulent Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 chronic atticoantral disease 11.3
2 otitis media 10.5
3 labyrinthitis 10.0
4 focal labyrinthitis 10.0
5 suppurative otitis media 9.6 HSF4 WIPF1

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media

Symptoms & Phenotypes for Chronic Purulent Otitis Media

MGI Mouse Phenotypes related to Chronic Purulent Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 FLNA RUNX1T1 TLR9 WIPF1

Drugs & Therapeutics for Chronic Purulent Otitis Media

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
2
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4 Anti-Bacterial Agents Phase 4,Phase 1,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 1,Not Applicable
6 Topoisomerase Inhibitors Phase 4,Phase 1
7 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable
8 Antidotes Phase 4
9 Antiemetics Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antineoplastic Agents, Hormonal Phase 4
12 Antioxidants Phase 4
13 Antiviral Agents Phase 4
14 Autonomic Agents Phase 4
15 BB 1101 Phase 4
16 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
17 Dexamethasone acetate Phase 4 1177-87-3
18 Expectorants Phase 4
19 Gastrointestinal Agents Phase 4
20 glucocorticoids Phase 4
21 HIV Protease Inhibitors Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
25 N-monoacetylcystine Phase 4
26 Peripheral Nervous System Agents Phase 4
27 Pharmaceutical Solutions Phase 4
28
protease inhibitors Phase 4
29 Protective Agents Phase 4
30 Respiratory System Agents Phase 4
31 Pazufloxacin Investigational Phase 1 127045-41-4
32 Antitubercular Agents Phase 1
33 Fluoroquinolones Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 1
35
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
36
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
37
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
38
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
39 Antimalarials Not Applicable
40 Antiparasitic Agents Not Applicable
41 Antiprotozoal Agents Not Applicable
42 Folic Acid Antagonists Not Applicable
43 Renal Agents Not Applicable
44 Trimethoprim, Sulfamethoxazole Drug Combination Not Applicable
45 Vitamin B Complex Not Applicable
46 Folate Nutraceutical Not Applicable
47 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Pazufloxacin Mesilate Ear Drops Clinical Trial Protocol Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in Rural Malawi Unknown status NCT02779907
4 Host-pathogen Interaction in Otitis Media Unknown status NCT00847756
5 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
6 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
7 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
8 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable

Search NIH Clinical Center for Chronic Purulent Otitis Media

Genetic Tests for Chronic Purulent Otitis Media

Anatomical Context for Chronic Purulent Otitis Media

Publications for Chronic Purulent Otitis Media

Articles related to Chronic Purulent Otitis Media:

# Title Authors Year
1
Chronic purulent otitis media: the prevailing pathology form among northern nationalities. ( 1365253 )
1991
2
Study of diffusion of cefuroxime into middle ear effusions of patients with chronic purulent otitis media. ( 7142073 )
1982
3
The treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 18143038 )
1949
4
Modified technic of plastic procedure in radical mastoidectomy; report of results in a case of circumscribed labyrinthitis and periphlebitis of the lateral sinus in the course of chronic purulent otitis media with cholesteatoma. ( 15394995 )
1949
5
Chronic purulent otitis media. ( 18919212 )
1947
6
Chronic purulent otitis media. ( 20260367 )
1947
7
A different treatment of chronic purulent otitis media; deep lavage, aeration and application of gold foil membrane bearing ointment of scarlet red. ( 18896820 )
1947
8
Treatment of chronic purulent otitis media with glycerite of hydrogen peroxide. ( 20993474 )
1946
9
Chronic Purulent Otitis Media: Its Treatment with Iodin Powder (Sulzberger). ( 18742568 )
1933
10
Indications for Operation in Chronic Purulent Otitis Media. ( 18734787 )
1909

Variations for Chronic Purulent Otitis Media

Expression for Chronic Purulent Otitis Media

Search GEO for disease gene expression data for Chronic Purulent Otitis Media.

Pathways for Chronic Purulent Otitis Media

GO Terms for Chronic Purulent Otitis Media

Cellular components related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.62 FLNA WIPF1

Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 8.62 TLR9 TNN

Sources for Chronic Purulent Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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