MCID: CHR097
MIFTS: 35

Chronic Purulent Otitis Media

Categories: Ear diseases

Aliases & Classifications for Chronic Purulent Otitis Media

MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 71
Chronic Suppurative Otitis Media 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14247
ICD9CM 34 382.3
NCIt 50 C128386
SNOMED-CT 67 38394007
ICD10 32 H66.3
UMLS 71 C0271454

Summaries for Chronic Purulent Otitis Media

Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to otitis media and suppurative otitis media. An important gene associated with Chronic Purulent Otitis Media is DHRS2 (Dehydrogenase/Reductase 2). The drugs carbamide peroxide and Pazufloxacin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and skin, and related phenotypes are hearing/vestibular/ear and respiratory system

Related Diseases for Chronic Purulent Otitis Media

Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.7 TLR4 TLR2 FBXO11 EYA4 A2ML1
2 suppurative otitis media 29.6 TLR4 TLR2 MECOM FBXO11 EYA4 DRC1
3 middle ear disease 29.4 TLR4 TLR2 FBXO11 EYA4 DHRS2 A2ML1
4 serous glue ear 11.4
5 chronic atticoantral disease 11.4
6 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
7 sensorineural hearing loss 10.8
8 mastoiditis 10.7
9 branchiootic syndrome 1 10.7
10 cholesteatoma of middle ear 10.6
11 otosclerosis 10.5
12 tympanosclerosis 10.5
13 lateral sinus thrombosis 10.5
14 haemophilus influenzae 10.5
15 discharging ear 10.4
16 bacterial infectious disease 10.4
17 thrombophlebitis 10.4
18 meningitis 10.4
19 pathologic nystagmus 10.4
20 cleft palate, isolated 10.4
21 otomycosis 10.4
22 subdural empyema 10.4
23 cellulitis 10.4
24 pleural empyema 10.4
25 otitis externa 10.4
26 perilymphatic fistula 10.3
27 migraine with or without aura 1 10.3
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
29 ocular motor apraxia 10.3
30 allergic rhinitis 10.3
31 mycobacterium tuberculosis 1 10.3
32 disease by infectious agent 10.3
33 adenoiditis 10.3
34 inflammatory myofibroblastic tumor 10.3
35 adenoid hypertrophy 10.3
36 bone resorption disease 10.3
37 mucositis 10.3
38 intracranial abscess 10.3
39 osteomyelitis 10.3
40 purulent acute otitis media 10.3
41 hydrocephalus 10.3
42 serous labyrinthitis 10.3
43 neurilemmoma 10.3
44 rhinitis 10.3
45 measles 10.3
46 cleft lip 10.3
47 intracranial hypertension 10.3
48 47,xyy 10.3
49 cleft lip/palate 10.3
50 spinal arachnoiditis 10.1

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media

Symptoms & Phenotypes for Chronic Purulent Otitis Media

MGI Mouse Phenotypes related to Chronic Purulent Otitis Media:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.43 BPIFA1 EYA4 FBXO11 MECOM RPL38 TLR4
2 respiratory system MP:0005388 9.1 BPIFA1 DRC1 MECOM RPL38 TLR2 TLR4

Drugs & Therapeutics for Chronic Purulent Otitis Media

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved Phase 1 124-43-6
2 Pazufloxacin Investigational Phase 1 127045-41-4
3 Antitubercular Agents Phase 1
4 Anti-Infective Agents, Local Phase 1
5 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Withdrawn NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Phase I´╝îPazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Unknown status NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
3 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in a Rural District of Malawi: A Cross-sectional Survey Unknown status NCT02779907
4 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Unknown status NCT03456739

Search NIH Clinical Center for Chronic Purulent Otitis Media

Genetic Tests for Chronic Purulent Otitis Media

Anatomical Context for Chronic Purulent Otitis Media

MalaCards organs/tissues related to Chronic Purulent Otitis Media:

40
Brain, Temporal Lobe, Skin, Eye, Cerebellum, T Cells, Neutrophil

Publications for Chronic Purulent Otitis Media

Articles related to Chronic Purulent Otitis Media:

(show top 50) (show all 1503)
# Title Authors PMID Year
1
Acute otitis media and pneumococcal vaccination - an observational cross-sectional study of otitis media among vaccinated and unvaccinated children in Greenland. 61
33407056 2021
2
Topical versus systemic antibiotics for chronic suppurative otitis media. 61
33561891 2021
3
Otolaryngeal and Oropharyngeal Conditions: Common Ear Conditions. 61
33595266 2021
4
Retroauricular Abscess in Adults. 61
33605218 2021
5
Silencing Nrf2 attenuates chronic suppurative otitis media by inhibiting pro-inflammatory cytokine secretion through up-regulating TLR4. 61
32579053 2021
6
Evaluation and comparison of tympanoplasty efficacy with tympanic membrane perforation after chronic suppurative otitis media in dry ear with different microorganisms. 61
33454455 2021
7
Investigating the use of a two-stage attention-aware convolutional neural network for the automated diagnosis of otitis media from tympanic membrane images: a prediction model development and validation study. 61
33478963 2021
8
A systematic review of the impact of cigarettes and electronic cigarettes in otology. 61
33272335 2020
9
Surgical outcomes of simultaneous cochlear implantation with subtotal petrosectomy. 61
32518029 2020
10
Subjective Visual Vertical Testing in Patients With Chronic Suppurative Otitis Media. 61
32571144 2020
11
Floating labyrinth: A unique finding on CT scan. 61
32944108 2020
12
Follow up of a birth cohort to identify prevalence and risk factors for otitis media among Indian children in the eighth year of life. 61
32658800 2020
13
[The discussion on the application of simultaneous balloon Eustachian tuboplasty in the hearing reconstruction in patients with chronic suppurative otitis media]. 61
33254293 2020
14
Suppurative otitis media in Angola: clinical and demographic features. 61
32677730 2020
15
Chronic suppurative otitis media in Zimbabwean school children: a cross-sectional study. 61
33016257 2020
16
[A prospective comparative study on the short-term effect of endoscopic myringoplasty in dry and wet ears]. 61
33254289 2020
17
Upper Respiratory Tract Microbiome and Otitis Media Intertalk: Lessons from the Literature. 61
32887458 2020
18
Tympanoplasty With or Without Balloon Eustachian Tuboplasty for Chronic Suppurative Otitis Media With Obstructive Eustachian Tube Dysfunction. 61
32472920 2020
19
Aural toilet (ear cleaning) for chronic suppurative otitis media. 61
32926406 2020
20
Mucosal Type of Chronic Suppurative Otitis Media and the Long-Term Impact on Hearing Loss. 61
33029456 2020
21
[Clinical research advances of endoscopic tympanoplasty]. 61
33040515 2020
22
High-resolution computed tomography (HRCT) in pediatric and adult patients with unsafe chronic suppurative otitis media (CSOM) and its surgical correlation. 61
33110811 2020
23
Analysis of main pathogenic bacteria and drug sensitivity in patients with chronic suppurative otitis media and middle ear cholesteatoma in China. 61
32270423 2020
24
Poguntano effect on cell viability in cholesteatoma keratinocyte of chronic suppurative otitis media. 61
32662611 2020
25
Analysis on the correlation between Eustachian tube function and outcomes of type I tympanoplasty for chronic suppurative otitis media. 61
32400245 2020
26
Causality of Chronic Suppurative Otitis Media: An Observational Study. 61
32953341 2020
27
A novel mouse model of chronic suppurative otitis media and its use in preclinical antibiotic evaluation. 61
32851190 2020
28
Comprehensive Community Screening of Otological Patients by Trained Technicians Using a Telemedicine Device: An Efficient and Cost-Effective Way to Triage Patients With Ear Diseases. 61
32845807 2020
29
Use of a sternocleidomastoid rotational and cervical-fascial advancement flap for closure of a persistent mastoid cutaneous fistula. 61
32772935 2020
30
Tuberculous otitis media with osteomyelitis of the regional craniofacial bones. 61
32862169 2020
31
Chronic suppurative otitis media due to Streptomyces cacaoi, the second case report in human infection. 61
32652948 2020
32
Unsolved problems and new medical approaches to otitis media. 61
32178551 2020
33
Bacteriology of Chronic Supporative Otitis Media (CSOM) at a Tertiary Care Hospital, Mymensingh. 61
32844792 2020
34
Outcome of surgery for chronic suppurative otitis media with resistant Pseudomonas aeruginosa. 61
32583180 2020
35
Application of Enhanced Recovery After Surgery in Perioperative Period of Tympanoplasty and Mastoidectomy. 61
32551958 2020
36
Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. 61
31567561 2020
37
[Patient-reported outcome measures as evaluation parameters in chronic suppurative otitis media]. 61
32842375 2020
38
Clinical Profile and Outcome of Brain Abscess in Children from a Tertiary Care Hospital in Eastern Uttar Pradesh. 61
32606516 2020
39
Endoscopic cartilage tympanoplasty: full thickness and partial thickness tragal graft. 61
30837190 2020
40
Management of Foreign Bodies in the Ear: A Retrospective Review of 123 Cases in Nigeria. 61
32396019 2020
41
[Analysis of comorbid psychiatric disorders in patients with chronic otitis media associated tinnitus]. 61
32842231 2020
42
Bacteriological Profile of Chronic Suppurative Otitis Media and Antibiotic Susceptibility in a Tertiary Care Hospital in Shanghai, China. 61
32352873 2020
43
Postoperative change in wideband absorbance after tympanoplasty in chronic suppurative otitis media. 61
31481240 2020
44
Inner-Ear Disorders Presenting with Air-Bone Gaps: A Review. 61
32401207 2020
45
Cochlear Dysfunction in Chronic Otitis Media and Its Determinants. 61
32219073 2020
46
The Association of IL-1 Alpha Level and TNF Alpha Expressions on Bone Destruction in Chronic Suppurative Otitis Media and Cholesteatoma. 61
32158647 2020
47
Implantation of bone-anchored hearing device using a three-dimensional template in a child. 61
32079553 2020
48
High Human Papillomavirus DNA loads in Inflammatory Middle Ear Diseases. 61
32197385 2020
49
[Effect of tympanoplasty on wet ear with different mucosal status of tympanic cavity]. 61
32086911 2020
50
[Risk Factors for Postoperative Recurrence of Chronic Suppurative Otitis Media]. 61
32131941 2020

Variations for Chronic Purulent Otitis Media

Expression for Chronic Purulent Otitis Media

Search GEO for disease gene expression data for Chronic Purulent Otitis Media.

Pathways for Chronic Purulent Otitis Media

GO Terms for Chronic Purulent Otitis Media

Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 9.54 RPL38 FBXO11 EYA4
2 positive regulation of interferon-beta production GO:0032728 9.46 TLR4 TLR2
3 lipopolysaccharide-mediated signaling pathway GO:0031663 9.43 TLR4 TLR2
4 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.4 TLR4 TLR2
5 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.32 TLR4 TLR2
6 I-kappaB phosphorylation GO:0007252 9.26 TLR4 TLR2
7 cellular response to lipoteichoic acid GO:0071223 9.16 TLR4 TLR2
8 positive regulation of matrix metallopeptidase secretion GO:1904466 8.96 TLR4 TLR2
9 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 8.62 TLR4 TLR2

Molecular functions related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.26 TLR4 TLR2
2 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.16 TLR4 TLR2
3 NAD(P)+ nucleosidase activity GO:0050135 8.96 TLR4 TLR2
4 lipopolysaccharide receptor activity GO:0001875 8.62 TLR4 TLR2

Sources for Chronic Purulent Otitis Media

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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