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MCID: CHR097
MIFTS: 33

Chronic Purulent Otitis Media

Categories: Ear diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Chronic Purulent Otitis Media

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MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 71
Chronic Suppurative Otitis Media 12

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14247
ICD9CM 34 382.3
NCIt 49 C128386
SNOMED-CT 67 38394007
ICD10 32 H66.3
UMLS 71 C0271454
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Summaries for Chronic Purulent Otitis Media

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Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to otitis media and discharging ear. An important gene associated with Chronic Purulent Otitis Media is DHRS2 (Dehydrogenase/Reductase 2). The drugs carbamide peroxide and Pazufloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes, and related phenotypes are craniofacial and hearing/vestibular/ear

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Related Diseases for Chronic Purulent Otitis Media

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Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 otitis media 31.6 FBXO11 EYA4 A2ML1
2 discharging ear 30.9 HM13 FLNA
3 auditory system disease 29.9 EYA4 DHRS2 COCH
4 middle ear disease 29.8 PDZD11 FBXO11 EYA4 DHRS2 A2ML1
5 suppurative otitis media 29.0 PDZD11 NR2F6 MECOM HM13 FLNA FBXO11
6 serous glue ear 11.6
7 chronic atticoantral disease 11.6
8 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
9 sensorineural hearing loss 10.7
10 mastoiditis 10.7
11 branchiootic syndrome 1 10.7
12 facial paralysis 10.6
13 cholesteatoma of middle ear 10.6
14 otosclerosis 10.5
15 tympanosclerosis 10.5
16 lateral sinus thrombosis 10.5
17 haemophilus influenzae 10.5
18 bacterial infectious disease 10.4
19 thrombophlebitis 10.4
20 meningitis 10.4
21 pathologic nystagmus 10.4
22 cleft palate, isolated 10.3
23 otomycosis 10.3
24 subdural empyema 10.3
25 cellulitis 10.3
26 pleural empyema 10.3
27 otitis externa 10.3
28 perilymphatic fistula 10.3
29 migraine with or without aura 1 10.3
30 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
31 ocular motor apraxia 10.3
32 allergic rhinitis 10.3
33 adenoiditis 10.3
34 inflammatory myofibroblastic tumor 10.3
35 adenoid hypertrophy 10.3
36 thrombosis 10.3
37 bone resorption disease 10.3
38 mucositis 10.3
39 intracranial abscess 10.3
40 osteomyelitis 10.3
41 purulent acute otitis media 10.3
42 hydrocephalus 10.3
43 neutropenia 10.3
44 serous labyrinthitis 10.3
45 neurilemmoma 10.3
46 rhinitis 10.3
47 measles 10.3
48 cleft lip 10.3
49 intracranial hypertension 10.3
50 cleft lip/palate 10.3

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media
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Symptoms & Phenotypes for Chronic Purulent Otitis Media

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MGI Mouse Phenotypes related to Chronic Purulent Otitis Media:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.43 DRC1 EYA4 FBXO11 FLNA HM13 MECOM
2 hearing/vestibular/ear MP:0005377 9.02 COCH EYA4 FBXO11 HM13 MECOM
Sources

Drugs & Therapeutics for Chronic Purulent Otitis Media

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Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved Phase 1 124-43-6
2 Pazufloxacin Investigational Phase 1 127045-41-4
3 Fluoroquinolones Phase 1
4 Antitubercular Agents Phase 1
5 Anti-Infective Agents, Local Phase 1
6
leucovorin Approved 58-05-9 6006 143
7
Sulfamethoxazole Approved 723-46-6 5329
8
Trimethoprim Approved, Vet_approved 738-70-5 5578
9
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10 Antibiotics, Antitubercular
11 Vitamin B Complex
12 Antiprotozoal Agents
13 Folate
14 Folic Acid Antagonists
15 Trimethoprim, Sulfamethoxazole Drug Combination
16 Antiparasitic Agents
17 Vitamin B9
18 Antimalarials

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Withdrawn NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in a Rural District of Malawi: A Cross-sectional Survey Unknown status NCT02779907
5 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Unknown status NCT03456739
6 Endoscopic Tympanoplasty: Single Versus Double Flap Technique Completed NCT03922295
7 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Sulfamethoxazole-trimethoprim;Placebo
8 Comparison of Half-thickness Tragal Cartilage Graft to Temporalis Fascia Graft Completed NCT03817242

Search NIH Clinical Center for Chronic Purulent Otitis Media

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Genetic Tests for Chronic Purulent Otitis Media

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Anatomical Context for Chronic Purulent Otitis Media

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MalaCards organs/tissues related to Chronic Purulent Otitis Media:

40
Bone, Brain, Testes, Temporal Lobe, Colon, Skin, T Cells
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Publications for Chronic Purulent Otitis Media

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Articles related to Chronic Purulent Otitis Media:

(show top 50) (show all 1466)
# Title Authors PMID Year
1
Surgical outcomes of simultaneous cochlear implantation with subtotal petrosectomy. 61
32518029 2020
2
Subjective Visual Vertical Testing in Patients With Chronic Suppurative Otitis Media. 61
32571144 2020
3
Silencing Nrf2 attenuates chronic suppurative otitis media by inhibiting pro-inflammatory cytokine secretion through up-regulating TLR4. 61
32579053 2020
4
Application of Enhanced Recovery After Surgery in Perioperative Period of Tympanoplasty and Mastoidectomy. 61
32551958 2020
5
Management of Foreign Bodies in the Ear: A Retrospective Review of 123 Cases in Nigeria. 61
32396019 2020
6
Endoscopic cartilage tympanoplasty: full thickness and partial thickness tragal graft. 61
30837190 2020
7
Tympanoplasty With or Without Balloon Eustachian Tuboplasty for Chronic Suppurative Otitis Media With Obstructive Eustachian Tube Dysfunction. 61
32472920 2020
8
Analysis on the correlation between Eustachian tube function and outcomes of type I tympanoplasty for chronic suppurative otitis media. 61
32400245 2020
9
Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. 61
31567561 2020
10
Inner-Ear Disorders Presenting with Air-Bone Gaps: A Review. 61
32401207 2020
11
Postoperative change in wideband absorbance after tympanoplasty in chronic suppurative otitis media. 61
31481240 2020
12
Unsolved problems and new medical approaches to otitis media. 61
32178551 2020
13
Bacteriological Profile of Chronic Suppurative Otitis Media and Antibiotic Susceptibility in a Tertiary Care Hospital in Shanghai, China. 61
32352873 2020
14
Analysis of main pathogenic bacteria and drug sensitivity in patients with chronic suppurative otitis media and middle ear cholesteatoma in China. 61
32270423 2020
15
High Human Papillomavirus DNA loads in Inflammatory Middle Ear Diseases. 61
32197385 2020
16
The Association of IL-1 Alpha Level and TNF Alpha Expressions on Bone Destruction in Chronic Suppurative Otitis Media and Cholesteatoma. 61
32158647 2020
17
Implantation of bone-anchored hearing device using a three-dimensional template in a child. 61
32079553 2020
18
Cochlear Dysfunction in Chronic Otitis Media and Its Determinants. 61
32219073 2020
19
[Effect of tympanoplasty on wet ear with different mucosal status of tympanic cavity]. 61
32086911 2020
20
[Risk Factors for Postoperative Recurrence of Chronic Suppurative Otitis Media]. 61
32131941 2020
21
Brain Abscess Presenting as Prolonged Headache in a Patient with Amyotrophic Lateral Sclerosis under Mechanical Ventilation. 61
31611533 2020
22
Preparing the surgical area for non-shaved ear surgery: a clinical assessment. 61
31930946 2020
23
Evaluation of Type III Tympanoplasty Using Cartilage Ossiculoplasty in Cholesteatoma Ear Surgery. 61
30974998 2020
24
[Clinical characteristics and efficacy analysis of secondary benign paroxysm positional vertigo after middle ear surgery]. 61
32086905 2020
25
Childhood hearing impairment and its associated factors in sub-Saharan Africa in the 21st century: A systematic review and meta-analysis. 61
32435486 2020
26
Topical antibiotics for chronic suppurative otitis media. 61
31896168 2020
27
Topical antiseptics for chronic suppurative otitis media. 61
31902140 2020
28
Chronic Suppurative Otitis Media: A Case Report. 61
32423374 2020
29
Antibiotics versus topical antiseptics for chronic suppurative otitis media. 61
31902139 2020
30
[Conservative treatment of exacerbation of chronic purulent otitis media]. 61
32476388 2020
31
Cochlear Implantation in Patients with Chronic Suppurative Otitis Media: Surgical Outcomes and a Management Algorithm. 61
32018243 2020
32
Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study. 61
30998545 2020
33
[Giant temporal bone cholesteatoma]. 61
32476392 2020
34
Cephalic Tetanus Presenting as Ptosis. 61
31937706 2020
35
Ototopical drops containing a novel antibacterial synthetic peptide: Safety and efficacy in adults with chronic suppurative otitis media. 61
32287316 2020
36
Antimicrobial Activity of Garlic Derivatives on Common Causative Microorganisms of the External Ear Canal and Chronic Middle Ear Infections. 61
32128511 2019
37
[Temporal bone cholesterol granuloma penetrating into the middle cranial fossa]. 61
31868006 2019
38
[Anatomy and function of the Eustachian tube influence the development of chronic suppurative otitis media]. 61
31914256 2019
39
Prevalence of hearing impairment amongst school going children in the rural field practice area of the institution. 61
31750218 2019
40
Comparison of Ossiculoplasty Using Autograft Ossicle Versus Allograft (Teflon). 61
31750170 2019
41
The Role of Preoperative Computed Tomography of Temporal Bone in Atticotomy as a New Tool for Determining the Approach. 61
31750163 2019
42
To Study the Association of the Size and Site of Tympanic Membrane Perforation with the Degree of Hearing Loss. 61
31750125 2019
43
Post-operative Sensorineural Hearing Loss After Middle Ear Surgery. 61
31750173 2019
44
Morphometric Analysis of the External Auditory Canal by Computed Tomography in Indian Population. 61
31750135 2019
45
Bacteriological Profile in Attico-antral type of Chronic Suppurative Otitis Media. 61
31750187 2019
46
Current Microbiological Trends of Chronic Suppurative Otitis Media in a Tertiary Care Centre, Mysuru, India. 61
31750194 2019
47
Bacteriological Profile and Antimicrobial Susceptibility Pattern in Chronic Suppurative Otitis Media: A 1-Year Cross-Sectional Study. 61
31750155 2019
48
Genetically Diversity of Pseudomonas aeruginosa Isolated from Chronic Suppurative Otitis Media with Respect to Their Antibiotic Sensitivity Pattern. 61
31750169 2019
49
Prevalence of Chronic Suppurative Otitis Media Among School Children Residing in Rural Area of Belagavi, South India. 61
31750215 2019
50
Differential Diagnosis of Post Auricular Swelling with Mastoid Bone Involvement. 61
31750180 2019
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Variations for Chronic Purulent Otitis Media

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Expression for Chronic Purulent Otitis Media

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Search GEO for disease gene expression data for Chronic Purulent Otitis Media.
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Pathways for Chronic Purulent Otitis Media

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GO Terms for Chronic Purulent Otitis Media

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Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 8.8 FBXO11 EYA4 COCH
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Sources for Chronic Purulent Otitis Media

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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