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MCID: CHR097
MIFTS: 32

Chronic Purulent Otitis Media

Categories: Ear diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Chronic Purulent Otitis Media

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MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 72
Chronic Suppurative Otitis Media 12

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:14247
ICD9CM 35 382.3
NCIt 50 C128386
SNOMED-CT 68 38394007
ICD10 33 H66.3
UMLS 72 C0271454
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Summaries for Chronic Purulent Otitis Media

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Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to serous glue ear and chronic atticoantral disease. An important gene associated with Chronic Purulent Otitis Media is WIPF1 (WAS/WASL Interacting Protein Family Member 1). The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes.

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Related Diseases for Chronic Purulent Otitis Media

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Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 serous glue ear 11.6
2 chronic atticoantral disease 11.6
3 otitis media 11.1
4 suppurative otitis media 11.1
5 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
6 sensorineural hearing loss 10.7
7 mastoiditis 10.7
8 branchiootic syndrome 1 10.7
9 facial paralysis 10.6
10 cholesteatoma of middle ear 10.6
11 tympanosclerosis 10.5
12 otosclerosis 10.5
13 lateral sinus thrombosis 10.5
14 haemophilus influenzae 10.5
15 discharging ear 10.4
16 bacterial infectious disease 10.4
17 thrombophlebitis 10.4
18 meningitis 10.4
19 pathologic nystagmus 10.4
20 cleft palate, isolated 10.3
21 otomycosis 10.3
22 subdural empyema 10.3
23 cellulitis 10.3
24 pleural empyema 10.3
25 middle ear disease 10.3
26 otitis externa 10.3
27 perilymphatic fistula 10.3
28 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
29 ocular motor apraxia 10.3
30 allergic rhinitis 10.3
31 adenoiditis 10.3
32 inflammatory myofibroblastic tumor 10.3
33 adenoid hypertrophy 10.3
34 thrombosis 10.3
35 bone resorption disease 10.3
36 mucositis 10.3
37 intracranial abscess 10.3
38 osteomyelitis 10.3
39 purulent acute otitis media 10.3
40 hydrocephalus 10.3
41 neutropenia 10.3
42 serous labyrinthitis 10.3
43 rhinitis 10.3
44 measles 10.3
45 cleft lip 10.3
46 intracranial hypertension 10.3
47 congenital hydrocephalus 10.3
48 cleft lip/palate 10.3
49 spinal arachnoiditis 10.1
50 penicillin allergy 10.1

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media
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Symptoms & Phenotypes for Chronic Purulent Otitis Media

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Drugs & Therapeutics for Chronic Purulent Otitis Media

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DrugBank drugs 16 :

# Drug Name Indication DrugBank ID
1 Ofloxacin For the treatment of infections (respiratory tract, kidney, skin, soft tissue, UTI), urethral and cervical gonorrhoea. DB01165

Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
4
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
5 Topoisomerase Inhibitors Phase 4
6 Anti-Bacterial Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Cytochrome P-450 Enzyme Inhibitors Phase 4
9 Hormone Antagonists Phase 4
10 Antiemetics Phase 4
11 N-monoacetylcystine Phase 4
12 Gastrointestinal Agents Phase 4
13 Antidotes Phase 4
14 HIV Protease Inhibitors Phase 4
15 Antioxidants Phase 4
16 Free Radical Scavengers Phase 4
17 Hormones Phase 4
18
protease inhibitors Phase 4
19 Peripheral Nervous System Agents Phase 4
20 glucocorticoids Phase 4
21 Anti-Inflammatory Agents Phase 4
22 Respiratory System Agents Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Protective Agents Phase 4
25 Pharmaceutical Solutions Phase 4
26 Expectorants Phase 4
27 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
28 Antiviral Agents Phase 4
29 Autonomic Agents Phase 4
30 BB 1101 Phase 4
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
32
carbamide peroxide Approved Phase 1 124-43-6
33 Pazufloxacin Investigational Phase 1 127045-41-4
34 Fluoroquinolones Phase 1
35 Nucleic Acid Synthesis Inhibitors Phase 1
36 Anti-Infective Agents, Local Phase 1
37 Antitubercular Agents Phase 1
38
Trimethoprim Approved, Vet_approved 738-70-5 5578
39
leucovorin Approved 58-05-9 143 6006
40
Sulfamethoxazole Approved 723-46-6 5329
41
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
42 Folic Acid Antagonists
43 Trimethoprim, Sulfamethoxazole Drug Combination
44 Renal Agents
45 Vitamin B9
46 Vitamin B Complex
47 Folate
48 Antiparasitic Agents
49 Antimalarials
50 Anti-Infective Agents, Urinary

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in a Rural District of Malawi: A Cross-sectional Survey Unknown status NCT02779907
5 Endoscopic Tympanoplasty: Single Versus Double Flap Technique Completed NCT03922295
6 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Sulfamethoxazole-trimethoprim;Placebo
7 Comparison of Half-thickness Tragal Cartilage Graft to Temporalis Fascia Graft Completed NCT03817242
8 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Not yet recruiting NCT03456739

Search NIH Clinical Center for Chronic Purulent Otitis Media

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ofloxacin
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Genetic Tests for Chronic Purulent Otitis Media

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Anatomical Context for Chronic Purulent Otitis Media

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MalaCards organs/tissues related to Chronic Purulent Otitis Media:

41
Bone, Brain, Testes, Temporal Lobe, Colon, Skin, T Cells
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Publications for Chronic Purulent Otitis Media

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Articles related to Chronic Purulent Otitis Media:

(show top 50) (show all 1406)
# Title Authors PMID Year
1
[Fibro-muscular-periosteal flap and bilobed flap for post-auricular cutaneous mastoid fistula closure]. 38
31169088 2019
2
Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway. 38
31346200 2019
3
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. 38
30049178 2019
4
Prevalence and etiological agents for chronic suppurative otitis media in a tertiary hospital in Tanzania. 38
31315659 2019
5
Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: study protocol for factorial design randomised controlled trial. 38
31351491 2019
6
Bacterial profile and antimicrobial susceptibility patterns in chronic suppurative otitis media at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. 38
31307545 2019
7
Effect of Incudostapedial Reconstruction Using Conchal Cartilage Interposition Graft on Hearing Outcome. 38
31360244 2019
8
Mastoid Cavity Myiasis: A Case Report and Review of the Literature. 38
31045903 2019
9
Clinimetric evaluation and clinical outcomes of the Dutch version of the Chronic Ear Survey. 38
31215443 2019
10
[Clinical observation of attic retraction pocket by otoendoscopes]. 38
31163534 2019
11
Retrosigmoid Approach for Vestibular Schwannoma. 38
31143585 2019
12
Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital. 38
31334487 2019
13
The association of allergy and chronic suppurative otitis media: A study in a tropical country. 38
31256174 2019
14
Etiology of Childhood Otorrhea in Luanda, Angola, and a Review of Otitis Media in African Children. 38
30516594 2019
15
Otitis media related hearing loss in Indonesian school children. 38
31252198 2019
16
Fungal Suppurative Otitis Media (Histopathology) Among Patients in North India. 38
29671212 2019
17
Effect of a participatory intervention in women's self-help groups for the prevention of chronic suppurative otitis media in their children in Jumla Nepal: a cluster-randomised trial. 38
31122224 2019
18
[Effects of preoperative secretions on dry ears after the surgery for chronic suppurative otitis media and cholesteatoma]. 38
31163544 2019
19
Anaerobic bacteriological profile of brain abscess in a tertiary care center in southern India. 38
31132411 2019
20
Readmissions After Day Care Surgery In Ent: A Tertiary Care Experience. 38
31094113 2019
21
Evaluation of Type III Tympanoplasty Using Cartilage Ossiculoplasty in Cholesteatoma Ear Surgery. 38
30974998 2019
22
[A multi-center retrospective study of ossiculoplasty surgery under oto-endoscope in 45 cases of conductive hearing loss with intact tympanic membrane]. 38
30991774 2019
23
Does The Type of Ossicular Chain Lesion Affect Outcomes in Chronic Suppurative Otitis Media Without Cholesteatoma? 38
30924779 2019
24
Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study. 38
30998545 2019
25
A Rare Case of Odontogenic Chronic Suppurative Otitis Media. 38
31172000 2019
26
Association of hearing loss with depression, anxiety and stress in patients suffering from Chronic Suppurative Otitis Media. 38
31086542 2019
27
Correlation of Eustachian Tube Dysfunction with Results of Tympanoplasty in Mucosal Type of Chronic Suppurative Otitis Media. 38
30906705 2019
28
Endoscopic cartilage tympanoplasty: full thickness and partial thickness tragal graft. 38
30837190 2019
29
Myringoplasty outcome. Five-year experience at a tertiary teaching hospital. 38
30723867 2019
30
Preventative and medical treatment of ear disease in remote or resource-constrained environments. 38
30706843 2019
31
Safety and Efficacy of Autologous Platelet-rich Fibrin on Graft Uptake in Myringoplasty: A Randomized Controlled Trial. 38
30647788 2019
32
Prevalence of Hearing Impairment in Mahabubnagar District, Telangana State, India. 38
29782444 2019
33
The Role of Routine Culture in the Treatment of Chronic Suppurative Otitis Media: Implications for the Standard of Care in Rural Areas of South Africa. 38
30626120 2019
34
The Value of Diffusion-Weighted MRI in the Long-term follow-up After Subtotal Petrosectomy for Extensive Cholesteatoma and Chronic Suppurative Otitis Media. 38
30531639 2019
35
Surgery for Chronic Otitis Media Causes Greater Taste Disturbance Than Surgery for Otosclerosis. 38
30540698 2019
36
[Evaluation of structural changes of bone in chronic purulent otitis media]. 38
30938335 2019
37
Guillain-Barré syndrome following bacterial meningitis: a case report and literature review. 38
30558576 2018
38
Differences in Antibiotic Resistance of MRSA Infections in Patients with Various Types of Otitis Media. 38
30541732 2018
39
The prevalence of otitis media in 2-3 year old Cameroonian children estimated by tympanometry. 38
30368383 2018
40
Surgical treatment of chronic ear disease in remote or resource-constrained environments. 38
30565532 2018
41
Three cases of Chronic Suppurative Otitis Media (CSOM) caused by Kerstersia gyiorum and a review of the literature. 38
30555142 2018
42
A Very Rare Case with Particular H-deficient Phenotypes. 38
30369771 2018
43
Actinomycosis of the Middle Ear and Mastoid. 38
30514999 2018
44
Prevalence of ear disease and associated hearing loss among primary school students in the Solomon Islands: Otitis media still a major public health issue. 38
30173991 2018
45
Tympanoplasty surgery: a retrospective audit of surgical outcomes at a regional hospital. 38
30264944 2018
46
Effectiveness of Type I Tympanoplasty in Wet and Dry Ear in Safe Chronic Suppurative Otitis Media. 38
30211083 2018
47
Pattern of tympanic membrane perforation in a tertiary hospital in Nigeria. 38
30074009 2018
48
Implementation and results of a surgical training programme for chronic suppurative otitis media in Cambodia. 38
29998817 2018
49
[Outcomes of same-day bilateral endoscopic tympanoplasty]. 38
30282174 2018
50
Anatomical and functional results of ossiculoplasty using titanium prosthesis. 38
30197429 2018
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Variations for Chronic Purulent Otitis Media

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Expression for Chronic Purulent Otitis Media

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Search GEO for disease gene expression data for Chronic Purulent Otitis Media.
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Pathways for Chronic Purulent Otitis Media

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GO Terms for Chronic Purulent Otitis Media

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Cellular components related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin filament GO:0005884 8.62 WIPF1 FLNA
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Sources for Chronic Purulent Otitis Media

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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