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MCID: CHR097
MIFTS: 32

Chronic Purulent Otitis Media

Categories: Ear diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Chronic Purulent Otitis Media

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MalaCards integrated aliases for Chronic Purulent Otitis Media:

Name: Chronic Purulent Otitis Media 12 15 71
Chronic Suppurative Otitis Media 12

Classifications:

MalaCards categories:
Anatomical: Ear diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:14247
ICD9CM 34 382.3
NCIt 49 C128386
SNOMED-CT 67 38394007
ICD10 32 H66.3
UMLS 71 C0271454
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Summaries for Chronic Purulent Otitis Media

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Disease Ontology : 12 A suppurative otitis media which is persistent and long-lasting.

MalaCards based summary : Chronic Purulent Otitis Media, also known as chronic suppurative otitis media, is related to otitis media and mastoiditis. An important gene associated with Chronic Purulent Otitis Media is DHRS2 (Dehydrogenase/Reductase 2). The drugs carbamide peroxide and Pazufloxacin have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and testes.

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Related Diseases for Chronic Purulent Otitis Media

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Diseases in the Purulent Acute Otitis Media family:

Chronic Purulent Otitis Media

Diseases related to Chronic Purulent Otitis Media via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 otitis media 31.6 FBXO11 EYA4 A2ML1
2 mastoiditis 31.3 SLC29A3 DHRS2
3 discharging ear 30.9 HM13 FLNA
4 non-suppurative otitis media 30.6 SLC29A3 DHRS2
5 suppurative otitis media 29.7 SLC29A3 PDZD11 MCAT HM13 FLNA FBXO11
6 auditory system disease 29.6 SLC29A3 EYA4 DHRS2 COCH
7 labyrinthitis 29.6 PATE1 COCH
8 middle ear disease 29.5 SLC29A3 PDZD11 MCAT FBXO11 EYA4 DHRS2
9 serous glue ear 11.6
10 chronic atticoantral disease 11.6
11 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
12 sensorineural hearing loss 10.7
13 branchiootic syndrome 1 10.7
14 facial paralysis 10.6
15 cholesteatoma of middle ear 10.6
16 tympanosclerosis 10.5
17 otosclerosis 10.5
18 lateral sinus thrombosis 10.5
19 haemophilus influenzae 10.5
20 bacterial infectious disease 10.4
21 thrombophlebitis 10.4
22 meningitis 10.4
23 pathologic nystagmus 10.4
24 cleft palate, isolated 10.3
25 otomycosis 10.3
26 subdural empyema 10.3
27 cellulitis 10.3
28 pleural empyema 10.3
29 otitis externa 10.3
30 perilymphatic fistula 10.3
31 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
32 ocular motor apraxia 10.3
33 allergic rhinitis 10.3
34 adenoiditis 10.3
35 inflammatory myofibroblastic tumor 10.3
36 adenoid hypertrophy 10.3
37 thrombosis 10.3
38 bone resorption disease 10.3
39 mucositis 10.3
40 intracranial abscess 10.3
41 osteomyelitis 10.3
42 purulent acute otitis media 10.3
43 hydrocephalus 10.3
44 neutropenia 10.3
45 serous labyrinthitis 10.3
46 neurilemmoma 10.3
47 rhinitis 10.3
48 measles 10.3
49 cleft lip 10.3
50 intracranial hypertension 10.3

Graphical network of the top 20 diseases related to Chronic Purulent Otitis Media:



Diseases related to Chronic Purulent Otitis Media
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Symptoms & Phenotypes for Chronic Purulent Otitis Media

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Drugs & Therapeutics for Chronic Purulent Otitis Media

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Drugs for Chronic Purulent Otitis Media (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved Phase 1 124-43-6
2 Pazufloxacin Investigational Phase 1 127045-41-4
3 Antitubercular Agents Phase 1
4 Fluoroquinolones Phase 1
5 Anti-Infective Agents, Local Phase 1
6
leucovorin Approved 58-05-9 6006 143
7
Trimethoprim Approved, Vet_approved 738-70-5 5578
8
Sulfamethoxazole Approved 723-46-6 5329
9
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10 Renal Agents
11 Folic Acid Antagonists
12 Antiparasitic Agents
13 Antiprotozoal Agents
14 Vitamin B Complex
15 Vitamin B9
16 Anti-Infective Agents, Urinary
17 Folate
18 Antimalarials
19 Trimethoprim, Sulfamethoxazole Drug Combination
20 Antibiotics, Antitubercular

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Withdrawn NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media Unknown status NCT02592096 Phase 1 0.1% Pazufloxacin Mesilate Ear Drops;0.3% Pazufloxacin Mesilate Ear Drops;0.5% Pazufloxacin Mesilate Ear Drops;Pazufloxacin mesilate injection
3 A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media Recruiting NCT03675841 Phase 1 Pazufloxacin Mesilate ear drops
4 Prevalence and Associations of Paediatric Chronic Suppurative Otitis Media and Hearing Impairment in a Rural District of Malawi: A Cross-sectional Survey Unknown status NCT02779907
5 Endoscopic Tympanoplasty: Single Versus Double Flap Technique Completed NCT03922295
6 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Sulfamethoxazole-trimethoprim;Placebo
7 Comparison of Half-thickness Tragal Cartilage Graft to Temporalis Fascia Graft Completed NCT03817242
8 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Media in Pediatric Patients in Northern Israel Not yet recruiting NCT03456739

Search NIH Clinical Center for Chronic Purulent Otitis Media

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Genetic Tests for Chronic Purulent Otitis Media

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Anatomical Context for Chronic Purulent Otitis Media

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MalaCards organs/tissues related to Chronic Purulent Otitis Media:

40
Bone, Brain, Testes, Temporal Lobe, Colon, Skin, T Cells
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Publications for Chronic Purulent Otitis Media

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Articles related to Chronic Purulent Otitis Media:

(show top 50) (show all 1441)
# Title Authors PMID Year
1
Cochlear Implantation in Patients with Chronic Suppurative Otitis Media: Surgical Outcomes and a Management Algorithm. 61
32018243 2020
2
Evaluation of Type III Tympanoplasty Using Cartilage Ossiculoplasty in Cholesteatoma Ear Surgery. 61
30974998 2020
3
Preparing the surgical area for non-shaved ear surgery: a clinical assessment. 61
31930946 2020
4
Otitis Media in Childhood and Disease in Adulthood: A 40-Year Follow-Up Study. 61
30998545 2020
5
Topical antiseptics for chronic suppurative otitis media. 61
31902140 2020
6
Topical antibiotics for chronic suppurative otitis media. 61
31896168 2020
7
Antibiotics versus topical antiseptics for chronic suppurative otitis media. 61
31902139 2020
8
Cephalic Tetanus Presenting as Ptosis. 61
31937706 2020
9
[Temporal bone cholesterol granuloma penetrating into the middle cranial fossa]. 61
31868006 2019
10
[Anatomy and function of the Eustachian tube influence the development of chronic suppurative otitis media]. 61
31914256 2019
11
To Study the Association of the Size and Site of Tympanic Membrane Perforation with the Degree of Hearing Loss. 61
31750125 2019
12
Post-operative Sensorineural Hearing Loss After Middle Ear Surgery. 61
31750173 2019
13
Comparison of Ossiculoplasty Using Autograft Ossicle Versus Allograft (Teflon). 61
31750170 2019
14
The Role of Preoperative Computed Tomography of Temporal Bone in Atticotomy as a New Tool for Determining the Approach. 61
31750163 2019
15
Morphometric Analysis of the External Auditory Canal by Computed Tomography in Indian Population. 61
31750135 2019
16
Bacteriological Profile in Attico-antral type of Chronic Suppurative Otitis Media. 61
31750187 2019
17
Current Microbiological Trends of Chronic Suppurative Otitis Media in a Tertiary Care Centre, Mysuru, India. 61
31750194 2019
18
Differential Diagnosis of Post Auricular Swelling with Mastoid Bone Involvement. 61
31750180 2019
19
A Comparative Study of Type-I Underlay Tympanoplasty with Temporalis Fascia Graft Alone and with Conchal Cartilage. 61
31750172 2019
20
A Comparative Study of the Efficacy of Fat Plug Myringoplasty and Conventional Myringoplasty in Chronic Suppurative Otitis Media with Small Central Perforation. 61
31750150 2019
21
A Clinical Study on Audiological Evaluation in Patients with Active Squamous Variety of Chronic Otitis Media Following Canal Wall Down Mastoidectomy with Ossicular Reconstruction. 61
31750222 2019
22
Bacteriological Profile and Antimicrobial Susceptibility Pattern in Chronic Suppurative Otitis Media: A 1-Year Cross-Sectional Study. 61
31750155 2019
23
Genetically Diversity of Pseudomonas aeruginosa Isolated from Chronic Suppurative Otitis Media with Respect to Their Antibiotic Sensitivity Pattern. 61
31750169 2019
24
Prevalence of Chronic Suppurative Otitis Media Among School Children Residing in Rural Area of Belagavi, South India. 61
31750215 2019
25
Prevalence of hearing impairment amongst school going children in the rural field practice area of the institution. 61
31750218 2019
26
Diagnose-Specific Antibiotic Prescribing Patterns at Otorhinolaryngology Inpatient Departments of Two Private Sector Healthcare Facilities in Central India: A Five-Year Observational Study. 61
31652748 2019
27
Anaerobic bacteriological profile of brain abscess in a tertiary care center in southern India. 61
31132411 2019
28
Effect of chronic suppurative otitis media on distortion product otoacoustic emission input-output functions in conventional and ultra-high frequencies. 61
31630702 2019
29
Otitis media related hearing loss in Indonesian school children. 61
31252198 2019
30
Brain Abscess Presenting as Prolonged Headache in a Patient with Amyotrophic Lateral Sclerosis under Mechanical Ventilation. 61
31611533 2019
31
[IgG4-associated diseases mainly with auricular symptoms: a case report and literature review]. 61
31446695 2019
32
Deep Learning in Automated Region Proposal and Diagnosis of Chronic Otitis Media Based on Computed Tomography. 61
31567561 2019
33
Postoperative change in wideband absorbance after tympanoplasty in chronic suppurative otitis media. 61
31481240 2019
34
Scanning Electron Microscopy in the Evaluation of Defects to the Ossicular Chain in the Course of Chronic Otitis Media. 61
31565971 2019
35
Parotid Gland Carcinoma Masquerading as an Aural Polyp. 61
31598500 2019
36
Facial nerve schwannoma mimicking chronic suppurative otitis media: A case report. 61
31464911 2019
37
Fibro-muscular-periosteal flap and bilobed flap for post-auricular cutaneous mastoid fistula closure. 61
31169088 2019
38
Otopathogenic Staphylococcus aureus Invades Human Middle Ear Epithelial Cells Primarily through Cholesterol Dependent Pathway. 61
31346200 2019
39
Prevalence and etiological agents for chronic suppurative otitis media in a tertiary hospital in Tanzania. 61
31315659 2019
40
Citric Acid as an Alternative to Boric Acid in the Treatment of Chronic Suppurative Otitis Media. 61
30049178 2019
41
Effect of Incudostapedial Reconstruction Using Conchal Cartilage Interposition Graft on Hearing Outcome. 61
31360244 2019
42
Mastoid Cavity Myiasis: A Case Report and Review of the Literature. 61
31045903 2019
43
Bacterial profile and antimicrobial susceptibility patterns in chronic suppurative otitis media at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia. 61
31307545 2019
44
Povidone-iodine ear wash and oral cotrimoxazole for chronic suppurative otitis media in Australian aboriginal children: study protocol for factorial design randomised controlled trial. 61
31351491 2019
45
Clinimetric evaluation and clinical outcomes of the Dutch version of the Chronic Ear Survey. 61
31215443 2019
46
[Clinical observation of attic retraction pocket by otoendoscopes]. 61
31163534 2019
47
Retrosigmoid Approach for Vestibular Schwannoma. 61
31143585 2019
48
Etiology of Childhood Otorrhea in Luanda, Angola, and a Review of Otitis Media in African Children. 61
30516594 2019
49
Surveillance of antibiotic sensitivity pattern in chronic suppurative otitis media of an Indian teaching hospital. 61
31334487 2019
50
The association of allergy and chronic suppurative otitis media: A study in a tropical country. 61
31256174 2019
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Variations for Chronic Purulent Otitis Media

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Expression for Chronic Purulent Otitis Media

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Search GEO for disease gene expression data for Chronic Purulent Otitis Media.
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Pathways for Chronic Purulent Otitis Media

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GO Terms for Chronic Purulent Otitis Media

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Biological processes related to Chronic Purulent Otitis Media according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sensory perception of sound GO:0007605 8.8 FBXO11 EYA4 COCH
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Sources for Chronic Purulent Otitis Media

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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