MCID: CHR098
MIFTS: 34

Chronic Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

MalaCards integrated aliases for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 12 54 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1076
ICD9CM 34 590.0
NCIt 50 C123216
SNOMED-CT 67 123293005
ICD10 32 N11
UMLS 70 C0085697

Summaries for Chronic Pyelonephritis

MalaCards based summary : Chronic Pyelonephritis is related to pyelonephritis and bacteriuria. An important gene associated with Chronic Pyelonephritis is UMOD (Uromodulin), and among its related pathways/superpathways are Antigen processing-Cross presentation and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include kidney, spinal cord and bone.

Related Diseases for Chronic Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 491)
# Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.8 UMOD TLR4 CRP CALCA ALB ACE
2 bacteriuria 30.4 UMOD TLR4 CRP ALB
3 cystitis 30.1 UMOD TLR4 CRP
4 proteinuria, chronic benign 30.0 REN B2M ALB ACE
5 urinary tract infection 30.0 UMOD TLR4 CRP ACE
6 renal tuberculosis 29.8 REN CRP B2M
7 gout 29.7 UMOD TLR4 ALB
8 optic papillitis 29.7 CRP ACE
9 acute pyelonephritis 29.7 CRP CALCA ALB ACE
10 bronchitis 29.7 TLR4 CRP ALB
11 xanthogranulomatous pyelonephritis 29.7 SERPINA3 CRP
12 cholecystitis 29.7 TLR4 CP CALCA ALB
13 eclampsia 29.7 REN ALB ACE
14 renal hypertension 29.7 REN ALB ACE
15 leprosy 3 29.6 TLR4 HLA-B HLA-A ALB
16 hypokalemia 29.6 REN ALB ACE
17 acute kidney failure 29.6 UMOD REN B2M ALB
18 pyuria 29.6 CRP B2M ALB
19 duodenal obstruction 29.6 CRP ALB
20 hydronephrosis 29.6 REN CRP B2M ALB
21 hypertensive encephalopathy 29.5 REN ALB ACE
22 kidney hypertrophy 29.5 REN ALB ACE
23 amyloidosis 29.2 SERPINA3 CRP B2M ALB
24 nephrotic syndrome 29.1 REN CRP B2M ALB ACE
25 bronchopneumonia 29.1 TLR4 SERPINA3 CRP ALB
26 uremia 29.1 REN CRP B2M ALB ACE
27 vesicoureteral reflux 1 29.0 UMOD REN CRP B2M ALB ACE
28 pre-eclampsia 29.0 TLR4 REN CRP ALB ACE
29 pneumonia 28.9 TLR4 CRP ALB ACE
30 urinary tract obstruction 28.9 UMOD REN CRP B2M ALB ACE
31 interstitial nephritis 28.9 UMOD REN CRP B2M ALB ACE
32 polycystic kidney disease 28.9 UMOD REN HLA-A B2M ALB ACE
33 acute cystitis 28.8 UMOD TLR4 SERPINA3 REN CRP ALB
34 hypothyroidism 28.6 REN CRP CALCA ALB ACE
35 kidney disease 28.5 UMOD SERPINA3 REN CRP B2M ALB
36 end stage renal disease 28.4 UMOD REN CRP B2M ALB ACE
37 deficiency anemia 28.3 SERPINA3 HLA-B CRP CP B2M ALB
38 hypertension, essential 27.8 UMOD TLR4 SERPINA3 REN CRP CALCA
39 torticollis, keloids, cryptorchidism, and renal dysplasia 11.0
40 glomerulonephritis 10.6
41 postherpetic neuralgia 10.4 HLA-B HLA-A
42 frontal fibrosing alopecia 10.4 HLA-B HLA-A
43 stevens-johnson syndrome/toxic epidermal necrolysis 10.4 HLA-B HLA-A
44 htlv-1 associated myelopathy/tropical spastic paraparesis 10.4 HLA-B HLA-A
45 epstein-barr virus hepatitis 10.4 HLA-B HLA-A
46 nephrolithiasis 10.4
47 spondylarthropathy 10.3 TLR4 HLA-B
48 nontuberculous mycobacterial lung disease 10.3 HLA-B HLA-A
49 selective igg deficiency disease 10.3 HLA-B HLA-A
50 colorectal cancer, hereditary nonpolyposis, type 8 10.3 HLA-B HLA-A

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to Chronic Pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

Drugs & Therapeutics for Chronic Pyelonephritis

Search Clinical Trials , NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

MalaCards organs/tissues related to Chronic Pyelonephritis:

40
Kidney, Spinal Cord, Bone, Heart, Cortex, Liver, Skin

Publications for Chronic Pyelonephritis

Articles related to Chronic Pyelonephritis:

(show top 50) (show all 2074)
# Title Authors PMID Year
1
Thyroidization in renal allografts. 61 54
19594588 2009
2
Proteinuria and renal tubular damage: urinary N-acetyl-beta-D-glucosaminidase and isoenzymes in dissimilar renal disease. 61 54
9627032 1998
3
[Usefulness of determining beta-2-microglobulin in serum and urine in patients with metabolically active kidney calculi and healthy individuals]. 54 61
8170811 1993
4
[The significance of microproteinuria for the diagnosis of kidney involvement in hypertensive disease and secondary forms of arterial hypertension]. 54 61
1440304 1992
5
A Bleeding Uretero-Arterial Fistula: Open Repair After Unsuccessful Endovascular Treatment. 61
32873221 2021
6
CT and MRI in Urinary Tract Infections: A Spectrum of Different Imaging Findings. 61
33401464 2021
7
Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report. 61
33317618 2020
8
Xanthogranulomatous pyelonephritis diagnosed in an austere environment. 61
33102070 2020
9
Toll-like 4 receptor (TLR4) expression on peripheral blood mononuclear cells in renal transplant recipients with pre-transplant chronic interstitial nephritis indicates patients at risk of graft deterioration. 61
32693120 2020
10
CT imaging of acute and chronic pyelonephritis: a practical guide for emergency radiologists. 61
32445022 2020
11
Imaging of Renal Infections and Inflammatory Disease. 61
32792123 2020
12
Non-diabetic Renal Diseases in Patients with Diabetes Mellitus Clinicopathological Correlation. 61
33707815 2020
13
Renal Stromal Expression of Oestrogen and Progesterone Receptors in Chronic Pyelonephritis as Compared to Normal Kidneys. 61
32893800 2020
14
Tertiary lymphoid tissue in kidneys: understanding local immunity and inflammation. 61
32709287 2020
15
Atypical focal xanthogranulomatous pyelonephritis without clinical symptoms presenting as infiltrative renal cancer: a case report and literature review. 61
32493295 2020
16
High-output cardiac failure secondary to high-output arteriovenous fistula: investigations, management and definitive treatment. 61
32111713 2020
17
Clinical, morphologic and histological features of chronic pyelonephritis: An 8-year review. 61
32003360 2020
18
[Features of chronic kidney disease in elderly patients.] 61
32362093 2020
19
Chronic kidney disease in preeclamptic patients: not found unless searched for-Is a nephrology evaluation useful after an episode of preeclampsia? 61
31317437 2019
20
[Predictors of perioperative complications in children with obstructive uropathy]. 61
31808640 2019
21
Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report. 61
31490399 2019
22
Xanthogranulomatous Pyelonephritis Causing Renocolic Fistula Presenting as Symptomatic Anemia. 61
31453021 2019
23
A Rare Manifestation of Tuberculosis in a Renal Transplant Patient: A Case Report. 61
31155204 2019
24
Renal pyelocalyceal squamous cell carcinoma in a patient with an ectopic kidney presenting with chronic pyelonephritis: a case report. 61
31118085 2019
25
Perinephric myxoid pseudotumor of fat: a distinctive pseudoneoplasm most often associated with non-neoplastic renal disease. 61
30826321 2019
26
Living-Donor Kidney Transplant in a Patient With Type B Mayer-Rokitansky-Küster-Hauser Syndrome, Reconstructed Vagina, and Abnormal Pelvic Vessels: A Case Report. 61
28540840 2019
27
[Comparative analysis of results in laparoscopic radical cystectomy with extracorporeal and intracorporeal neobladder formation]. 61
31184021 2019
28
Clinical profile of tuberculosis in patients with chronic kidney disease: A report from an endemic Country. 61
31031383 2019
29
Early start of clean intermittent catheterization versus expectant management in children with spina bifida. 61
30558962 2019
30
Spontaneous perirenal hemorrhage (Wunderlich syndrome): An analysis of 28 cases. 61
29779678 2019
31
Neutrophil-to-Lymphocyte Ratio in Renal Cell Carcinoma Patients. 61
31188772 2018
32
[Some epidemiological aspects of urinary tract infections in Altai regional hospital for veterans of wars]. 61
30742382 2018
33
[The changes in urine microflora in patients with urinary stone disease]. 61
30742375 2018
34
Studies on biofilm formation and virulence factors associated with uropathogenic Escherichia coli isolated from patient with acute pyelonephritis. 61
30032909 2018
35
Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms. 61
30031100 2018
36
Bear Paw Sign: Xanthogranulomatous Pyelonephritis. 61
30647833 2018
37
EFFECTIVENESS OF NONALCOHOLIC STEATOHEPATITIS CORRECTION ON THE BAСKGROUND OF OBESITY WITH CONCOMITANT CHRONIC KIDNEY DISEASE. 61
30516498 2018
38
[The role of modification of innate immunity in development of premature labore]. 61
30378561 2018
39
[Xanthogranulonatous pyelonephritis: report of 5 cases]. 61
30122783 2018
40
Trends in Urologic Indications for Pediatric Renal Transplantation Over a 27-Year-period United Network for Organ Sharing (UNOS) Database. 61
29154793 2018
41
Primary Squamous Cell Carcinoma of Renal Pelvis in Non-Functioning Kidneys. 61
29866254 2018
42
The pathological evaluation of nonneoplastic kidney disorder in tumor nephrectomy specimens. 61
29970734 2018
43
Proteflazid®: treatment of herpesvirus and mixed infections. Meta-analysis of clinical trials results. 61
29813042 2018
44
Bilateral renal abscessation and chronic active pyelonephritis in a male camel (Camelus dromedarius) caused by Escherichia coli. 61
29563349 2018
45
Surgical and endoscopic treatment of bladder exstrophy-epispadias complex in a female dog. 61
29504860 2018
46
INTENSITY OF THE ANTIOXIDANT PROTECTION SYSTEM AND OXIDATIVE STRESS FACTORS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS DEPENDING ON THE FORM OF CHRONIC KIDNEY DISEASE. 61
29697385 2018
47
Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy. 61
29441752 2018
48
[Features of urolithiasis in patients of advanced and senile age.] 61
30584876 2018
49
[Features of the proteome of the urine in chronic pyelonephritis.] 61
30720953 2018
50
Urinothorax Caused by Xanthogranulomatous Pyelonephritis. 61
30079257 2018

Variations for Chronic Pyelonephritis

Expression for Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for Chronic Pyelonephritis

Pathways related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 TLR4 HLA-B HLA-A B2M
2 11.46 HLA-B HLA-A B2M
3 10.2 HLA-B HLA-A B2M

GO Terms for Chronic Pyelonephritis

Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 UMOD SERPINA3 HLA-B HLA-A CP B2M
2 cell surface GO:0009986 9.83 UMOD TLR4 HLA-B HLA-A B2M
3 extracellular region GO:0005576 9.81 ACE ALB B2M CALCA CP CRP
4 recycling endosome membrane GO:0055038 9.63 HLA-B HLA-A B2M
5 extracellular space GO:0005615 9.61 ACE ALB B2M CALCA CP CRP
6 phagocytic vesicle membrane GO:0030670 9.54 HLA-B HLA-A B2M
7 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-B B2M HLA-A
8 MHC class I peptide loading complex GO:0042824 9.4 HLA-A B2M
9 MHC class I protein complex GO:0042612 8.8 HLA-B HLA-A B2M

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.89 B2M CRP HLA-A HLA-B TLR4
2 kidney development GO:0001822 9.74 UMOD REN ACE
3 cellular protein metabolic process GO:0044267 9.67 ALB B2M CALCA CP
4 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.65 B2M HLA-A HLA-B
5 inflammatory response GO:0006954 9.65 CALCA CRP SERPINA3 TLR4 UMOD
6 interferon-gamma-mediated signaling pathway GO:0060333 9.61 B2M HLA-A HLA-B
7 regulation of blood pressure GO:0008217 9.58 ACE CALCA REN
8 amyloid-beta metabolic process GO:0050435 9.56 REN ACE
9 angiotensin maturation GO:0002003 9.55 ACE REN
10 detection of bacterium GO:0016045 9.54 HLA-A HLA-B
11 positive regulation of T cell cytokine production GO:0002726 9.52 B2M HLA-A
12 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.51 B2M HLA-A
13 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.46 HLA-A HLA-B
14 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 B2M HLA-A HLA-B
15 protection from natural killer cell mediated cytotoxicity GO:0042270 9.32 HLA-A HLA-B
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.13 B2M HLA-A HLA-B
17 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.92 ACE B2M HLA-A HLA-B

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 TLR4 REN HLA-B HLA-A CALCA
2 chaperone binding GO:0051087 9.33 HLA-B CP ALB
3 TAP binding GO:0046977 8.62 HLA-B HLA-A

Sources for Chronic Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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