MCID: CHR098
MIFTS: 38

Chronic Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

MalaCards integrated aliases for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1076
ICD10 33 N11 N11.9
ICD9CM 35 590.0
NCIt 50 C123216
SNOMED-CT 68 63302006
UMLS 73 C0085697

Summaries for Chronic Pyelonephritis

MalaCards based summary : Chronic Pyelonephritis is related to pyelonephritis and bacteriuria. An important gene associated with Chronic Pyelonephritis is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Human cytomegalovirus infection and Interferon gamma signaling. The drugs Acetylcysteine and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and prostate, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 pyelonephritis 31.6 TLR4 UMOD
2 bacteriuria 29.9 TLR4 UMOD
3 cystitis 29.4 TLR4 UMOD
4 torticollis, keloids, cryptorchidism, and renal dysplasia 11.1
5 phenytoin or carbamazepine toxicity 10.2 HLA-B HLA-A
6 spondyloarthropathy 10.2 HLA-A HLA-B
7 postherpetic neuralgia 10.2 HLA-B HLA-A
8 atrial tachyarrhythmia with short pr interval 10.2 HLA-B HLA-A
9 pars planitis 10.2 HLA-B HLA-A
10 pityriasis rosea 10.2 HLA-B HLA-A
11 nontuberculous mycobacterial lung disease 10.2 HLA-B HLA-A
12 human herpesvirus 8 10.2 HLA-B HLA-A
13 boutonneuse fever 10.2 TLR4 CP
14 idiopathic bronchiectasis 10.2 HLA-B HLA-A
15 echinococcosis 10.2 HLA-B TLR4
16 histoplasmosis 10.2 HLA-B HLA-A
17 complex regional pain syndrome 10.1 CALCA HLA-B
18 pure red-cell aplasia 10.1 HLA-A HLA-B
19 cytomegalovirus retinitis 10.1 HLA-A HLA-B
20 osteitis fibrosa 10.1 CALCA B2M
21 amyloid tumor 10.1 CALCA B2M
22 hematopoietic stem cell transplantation 10.1 HLA-A HLA-B
23 glaucomatocyclitic crisis 10.1 HLA-A HLA-B
24 glomerulonephritis 10.1
25 multinodular goiter 10.1 CALCA CP
26 geographic tongue 10.1 HLA-A HLA-B
27 separation anxiety disorder 10.1 HLA-A HLA-B
28 panuveitis 10.1 HLA-A HLA-B
29 peroneal nerve paralysis 10.1 CPN1 CALCA
30 bacterial sepsis 10.1 CALCA TLR4
31 ovarian cystic teratoma 10.1 B2M CALCA
32 periodontosis 10.1 TLR4 HLA-A
33 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 HLA-A HLA-B
34 cloacogenic carcinoma 10.1 B2M CALCA
35 aphthous stomatitis 10.1 HLA-A HLA-B
36 paraneoplastic pemphigus 10.1 HLA-A HLA-B
37 prostate squamous cell carcinoma 10.1 HLA-A B2M
38 herpes zoster 10.1 HLA-A HLA-B
39 nephrotic syndrome 10.1
40 syphilis 10.1 B2M CP
41 dengue hemorrhagic fever 10.1 HLA-A HLA-B
42 salmonellosis 10.1 CP TLR4
43 hemorrhagic fever with renal syndrome 10.1 B2M HLA-B
44 vogt-koyanagi-harada disease 10.1 HLA-A HLA-B
45 malignant hypertension 10.0
46 hydronephrosis 10.0
47 severe cutaneous adverse reaction 10.0 HLA-A HLA-B
48 rubella 10.0 HLA-A HLA-B
49 acute kidney tubular necrosis 10.0 B2M UMOD
50 anterior uveitis 10.0 TLR4 HLA-B HLA-A

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to Chronic Pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

GenomeRNAi Phenotypes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.58 HLA-A HLA-B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.58 HLA-A HLA-B
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.58 HLA-A HLA-B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-156 9.58 HLA-A HLA-B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.58 HLA-A HLA-B
6 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.58 HLA-A HLA-B
7 Increased shRNA abundance (Z-score > 2) GR00366-A-31 9.58 HLA-A HLA-B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.58 HLA-A HLA-B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.58 HLA-A HLA-B

Drugs & Therapeutics for Chronic Pyelonephritis

Drugs for Chronic Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
2 Anti-Infective Agents Phase 2
3 Antiviral Agents Phase 2
4 Antioxidants Phase 2
5 Respiratory System Agents Phase 2
6 Expectorants Phase 2
7 N-monoacetylcystine Phase 2
8 Antidotes Phase 2
9 Free Radical Scavengers Phase 2
10 Protective Agents Phase 2
11 Hematinics
12 Epoetin alfa 113427-24-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Acetylcysteine in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
2 An Observational Study of Methoxy Polyethylene Glycol-epoetin Beta in Participants With a Kidney Transplant Completed NCT02538107 Methoxy-polyethyleneglycol epoetin beta

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

MalaCards organs/tissues related to Chronic Pyelonephritis:

41
Kidney, Testes, Prostate, Cortex, Lung, Bone, Tongue

Publications for Chronic Pyelonephritis

Articles related to Chronic Pyelonephritis:

(show top 50) (show all 287)
# Title Authors Year
1
Causal Neuro-immune Relationships at Patients with Chronic Pyelonephritis and Cholecystitis. Correlations between Parameters EEG, HRV and White Blood Cell Count. ( 28730179 )
2017
2
Role of genetic mutations in development of immunological and clinical disorders in children with chronic pyelonephritis. ( 28343193 )
2017
3
Urinary cytokines as markers of latent inflammation in children with chronic pyelonephritis and anorectal malformations. ( 26936433 )
2016
4
AJKD Atlas of Renal Pathology: Chronic Pyelonephritis. ( 27664481 )
2016
5
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. ( 27370410 )
2016
6
[Prevalence of Types TEM, SHV and CTX-M I^LES Among Pathogens of Chronic Pyelonephritis]. ( 26448990 )
2014
7
Incidental primary papillary mucinous adenocarcinoma of the renal pelvis in a case of non-functioning kidney due to chronic pyelonephritis and pelvic calculus. ( 22569454 )
2012
8
Estimation of the kidney functional reserve as the prognosis of preeclampsia development in the pregnant woman with chronic pyelonephritis and glomerulonephritis. ( 20614512 )
2010
9
Retroperitoneal-necrotizing fasciitis due to chronic pyelonephritis. ( 21063573 )
2010
10
Chronic pyelonephritis presenting as a renal sinus tumor with retroperitoneal extension: a case report. ( 19918288 )
2009
11
Erythropoiesis and iron metabolism biorhythms in children with chronic pyelonephritis. ( 19240844 )
2008
12
Chronic pyelonephritis presenting as multiple tumor-like renal lesions. ( 17575382 )
2007
13
[Combined rehabilitation of patients with chronic pyelonephritis]. ( 16862887 )
2006
14
Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers. ( 15177997 )
2004
15
Recurrent eclampsia in a woman with chronic pyelonephritis. ( 11165745 )
2001
16
Massive proteinuria in a patient with chronic pyelonephritis. ( 10831663 )
2000
17
Long-term follow-up of patients presenting to adult nephrologists with chronic pyelonephritis and 'normal' renal function. ( 11110586 )
2000
18
Effect of haemodialysis on peripheral lymphocyte carnitine levels in patients with chronic pyelonephritis. ( 10824328 )
1999
19
Chronic pyelonephritis in association with neuropathic bladder. ( 10661788 )
1999
20
An unusual granulomatous form of chronic pyelonephritis mimicking tuberculosis. ( 9639129 )
1998
21
[Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure]. ( 9621641 )
1998
22
Role of type-1 fimbriae in the pathogenesis of chronic pyelonephritis in relation to reactive oxygen species. ( 9152036 )
1997
23
Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. ( 9078596 )
1997
24
Development of experimental model of chronic pyelonephritis with Escherichia coli O75:K5:H-bearing Dr fimbriae: mutation in the dra region prevented tubulointerstitial nephritis. ( 9120010 )
1997
25
Urinary excretion of prostanoids in children with chronic pyelonephritis. ( 9547653 )
1997
26
[Hydrocortisol, parathyroid hormone and calcitonin in blood of patients with chronic pyelonephritis and nephrosclesosis]. ( 9471316 )
1997
27
[The bioregulatory therapy of patients with chronic pyelonephritis]. ( 9381626 )
1997
28
Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis. ( 9481514 )
1997
29
Development of multiple myeloma in 2 patients with chronic pyelonephritis and long-term hemodialysis treatment. ( 8742983 )
1996
30
Mechanisms of renal damage in chronic pyelonephritis (reflux nephropathy). ( 7614849 )
1995
31
An ascending non-obstructive model for chronic pyelonephritis in BALB/c mice. ( 7608952 )
1995
32
Clinical and histological criteria defining the diagnosis of active chronic pyelonephritis in pregnancy. ( 7774082 )
1995
33
Computed tomography evaluation of renal parenchymal volume in patients with chronic pyelonephritis and its relationship to glomerular filtration rate. ( 7735742 )
1995
34
[The clinical importance of histocompatibility antigens and their combinations in the diagnosis of chronic pyelonephritis]. ( 7940364 )
1994
35
Long-term urethral catheterization increases risk of chronic pyelonephritis and renal inflammation. ( 7983294 )
1994
36
[Renin-angiotensin-aldosterone system in peripheral blood and concentration of albumin and beta2 microglobulin in urine of women with chronic glomerulonephritis and chronic pyelonephritis]. ( 7817590 )
1994
37
Renocolic fistula secondary to chronic pyelonephritis. ( 8225822 )
1993
38
A case of nephrotic syndrome with chronic pyelonephritis. ( 8390018 )
1993
39
Chronic pyelonephritis masquerading as a renal neoplasm. ( 2024378 )
1991
40
Systemic amyloidosis (type AA) in end-stage renal failure patients due to chronic pyelonephritis. ( 1758552 )
1991
41
Chronic pyelonephritis: the significance of renal renin and the vascular changes in the human kidney. ( 2033493 )
1991
42
Nephrectomy in unilateral chronic pyelonephritis. A long-term follow-up study. ( 2210973 )
1990
43
Atubular glomeruli in patients with chronic pyelonephritis. ( 2332970 )
1990
44
Chronic pyelonephritis: modulation of host defenses by cyclosporin A. ( 2666534 )
1989
45
Virulence of Escherichia coli strains in relation to their hemolysin formation, mannose-resistant hemagglutination, hydroxamate production, K 1-antigen and the plasmid profile in patients with chronic pyelonephritis. ( 2680194 )
1989
46
Potentials of ultrasonography for early diagnosis of primary chronic pyelonephritis. ( 3068178 )
1988
47
P-fimbriae receptors in patients with chronic pyelonephritis. ( 2896254 )
1988
48
Haemorrhage due to rupture of the kidney with intraparenchymal calculi, chronic pyelonephritis and acute obstructive uropathy. A case report. ( 3187808 )
1988
49
Hypertension in chronic pyelonephritis. ( 3568676 )
1987
50
Chronic pyelonephritis in a brood mare. ( 3689265 )
1987

Variations for Chronic Pyelonephritis

Expression for Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for Chronic Pyelonephritis

GO Terms for Chronic Pyelonephritis

Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.67 B2M HLA-A HLA-B TLR4
2 early endosome membrane GO:0031901 9.5 B2M HLA-A HLA-B
3 recycling endosome membrane GO:0055038 9.43 B2M HLA-A HLA-B
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-A HLA-B
5 phagocytic vesicle membrane GO:0030670 9.33 B2M HLA-A HLA-B
6 ER to Golgi transport vesicle membrane GO:0012507 9.13 B2M HLA-A HLA-B
7 MHC class I protein complex GO:0042612 8.8 B2M HLA-A HLA-B

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.78 B2M HLA-A HLA-B TLR4
2 immune response GO:0006955 9.73 B2M HLA-A HLA-B TLR4
3 regulation of immune response GO:0050776 9.71 B2M HLA-A HLA-B
4 cellular protein metabolic process GO:0044267 9.7 B2M CALCA CP
5 type I interferon signaling pathway GO:0060337 9.56 HLA-A HLA-B
6 antigen processing and presentation GO:0019882 9.55 HLA-A HLA-B
7 interferon-gamma-mediated signaling pathway GO:0060333 9.54 B2M HLA-A HLA-B
8 leukocyte cell-cell adhesion GO:0007159 9.51 CALCA UMOD
9 positive regulation of interleukin-8 production GO:0032757 9.49 CALCA TLR4
10 negative regulation of osteoclast differentiation GO:0045671 9.46 CALCA TLR4
11 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.43 B2M HLA-A HLA-B
12 antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 9.4 HLA-A HLA-B
13 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.33 B2M HLA-A HLA-B
14 protection from natural killer cell mediated cytotoxicity GO:0042270 9.32 HLA-A HLA-B
15 positive regulation of T cell mediated cytotoxicity GO:0001916 9.13 B2M HLA-A HLA-B
16 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 8.8 B2M HLA-A HLA-B

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-A HLA-B
2 signaling receptor binding GO:0005102 8.92 CALCA HLA-A HLA-B TLR4

Sources for Chronic Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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