MCID: CHR098
MIFTS: 38

Chronic Pyelonephritis

Categories: Nephrological diseases

Aliases & Classifications for Chronic Pyelonephritis

MalaCards integrated aliases for Chronic Pyelonephritis:

Name: Chronic Pyelonephritis 12 54 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:1076
ICD9CM 34 590.0
NCIt 49 C123216
SNOMED-CT 67 63302006
ICD10 32 N11
UMLS 71 C0085697

Summaries for Chronic Pyelonephritis

MalaCards based summary : Chronic Pyelonephritis is related to xanthogranulomatous pyelonephritis and bacteriuria. An important gene associated with Chronic Pyelonephritis is UMOD (Uromodulin), and among its related pathways/superpathways are Antigen processing-Cross presentation and Antigen Presentation- Folding, assembly and peptide loading of class I MHC. The drugs Acetylcysteine and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and spinal cord, and related phenotypes are immune system and renal/urinary system

Related Diseases for Chronic Pyelonephritis

Diseases in the Pyelonephritis family:

Chronic Pyelonephritis Acute Pyelonephritis

Diseases related to Chronic Pyelonephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 428)
# Related Disease Score Top Affiliating Genes
1 xanthogranulomatous pyelonephritis 30.1 SERPINA3 NEXMIF
2 bacteriuria 30.1 UMOD TLR4 CRP ALB
3 cystitis 30.0 UMOD TLR4 CRP
4 pyelonephritis 30.0 UMOD TLR4 HLA-A CRP CALCA ALB
5 cholecystitis 29.8 TLR4 CP ALB
6 gout 29.6 UMOD TLR4 ALB
7 acute kidney failure 29.5 UMOD REN B2M ALB
8 eclampsia 29.4 REN ALB ACE
9 pyuria 29.4 CRP B2M ALB
10 hypokalemia 29.4 REN ALB ACE
11 acute pyelonephritis 29.4 CRP CALCA ALB ACE
12 bronchitis 29.3 TLR4 CRP CALCA ALB
13 duodenal obstruction 29.3 CRP ALB
14 hypertensive encephalopathy 29.3 REN ALB ACE
15 kidney hypertrophy 29.3 REN ALB ACE
16 renal tuberculosis 29.2 REN NEXMIF CRP B2M
17 optic papillitis 29.2 CRP ACE
18 hydronephrosis 29.2 REN CRP B2M ALB
19 subacute bacterial endocarditis 29.2 CRP ALB
20 amyloidosis 28.9 SERPINA3 CRP B2M ALB
21 bronchopneumonia 28.8 TLR4 SERPINA3 CRP ALB
22 neutropenia 28.8 TLR4 CRP CP ALB
23 immune deficiency disease 28.7 SERPINA3 HLA-B HLA-A B2M
24 deficiency anemia 28.7 CRP CP ALB ACE
25 end stage renal disease 28.6 UMOD REN CRP ALB ACE
26 uremia 28.6 REN CRP B2M ALB ACE
27 renal hypertension 28.6 REN CRP ALB ACE
28 pneumonia 28.6 TLR4 CRP ALB ACE
29 vesicoureteral reflux 1 28.5 UMOD REN CRP B2M ALB ACE
30 pre-eclampsia 28.4 TLR4 REN CRP ALB ACE
31 myeloma, multiple 28.4 TLR4 SERPINA3 CRP B2M ALB
32 urinary tract obstruction 28.4 UMOD REN CRP B2M ALB ACE
33 interstitial nephritis 28.3 UMOD REN CRP B2M ALB ACE
34 acute cystitis 28.2 UMOD TLR4 SERPINA3 REN CRP ALB
35 hypothyroidism 28.0 REN CRP CALCA ALB ACE
36 kidney disease 27.9 UMOD SERPINA3 REN CRP B2M ALB
37 hypertension, essential 26.8 UMOD TLR4 SERPINA3 REN LPXN CRP
38 diabetes mellitus 26.5 UMOD TLR4 REN HLA-B HLA-A CRP
39 torticollis, keloids, cryptorchidism, and renal dysplasia 11.3
40 postherpetic neuralgia 10.5 HLA-B HLA-A
41 glomerulonephritis 10.5
42 frontal fibrosing alopecia 10.5 HLA-B HLA-A
43 moyamoya angiopathy 10.5 HLA-B HLA-A
44 nontuberculous mycobacterial lung disease 10.5 HLA-B HLA-A
45 selective igg deficiency disease 10.4 HLA-B HLA-A
46 spondyloarthropathy 10.4 HLA-B HLA-A CALCA
47 idiopathic bronchiectasis 10.4 HLA-B HLA-A
48 autosomal dominant tubulointerstitial kidney disease, ren-related 10.3 UMOD REN
49 autosomal dominant tubulointerstitial kidney disease 10.3 UMOD REN
50 alveolar echinococcosis 10.3 TLR4 HLA-B HLA-A

Graphical network of the top 20 diseases related to Chronic Pyelonephritis:



Diseases related to Chronic Pyelonephritis

Symptoms & Phenotypes for Chronic Pyelonephritis

MGI Mouse Phenotypes related to Chronic Pyelonephritis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.7 ACE ALB B2M CP CPN1 CRP
2 renal/urinary system MP:0005367 9.17 ACE ALB NEXMIF REN TLR4 TMEM174

Drugs & Therapeutics for Chronic Pyelonephritis

Drugs for Chronic Pyelonephritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
2 Respiratory System Agents Phase 2
3 Anti-Infective Agents Phase 2
4 Antidotes Phase 2
5 Antioxidants Phase 2
6 Antiviral Agents Phase 2
7 Expectorants Phase 2
8 N-monoacetylcystine Phase 2
9 Protective Agents Phase 2
10
Parathyroid hormone Approved, Investigational 9002-64-6
11
carbamide peroxide Approved 124-43-6
12 Calcium, Dietary
13 Hormones
14
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of the Effect of Acetylcysteine on Inflammation Biomarkers in Pediatric Acute Pyelonephritis. Completed NCT02080182 Phase 2 Acetylcysteine;placebo acetylcysteine
2 Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis Unknown status NCT02488200
3 CausesOf End Stage Renal Disease In Patients Undergoing Regular Hemodialysis In Assiut University Hospital Not yet recruiting NCT03779750

Search NIH Clinical Center for Chronic Pyelonephritis

Genetic Tests for Chronic Pyelonephritis

Anatomical Context for Chronic Pyelonephritis

MalaCards organs/tissues related to Chronic Pyelonephritis:

40
Kidney, Testes, Spinal Cord, Heart, Bone, Cortex, Prostate

Publications for Chronic Pyelonephritis

Articles related to Chronic Pyelonephritis:

(show top 50) (show all 2063)
# Title Authors PMID Year
1
Thyroidization in renal allografts. 54 61
19594588 2009
2
Proteinuria and renal tubular damage: urinary N-acetyl-beta-D-glucosaminidase and isoenzymes in dissimilar renal disease. 54 61
9627032 1998
3
[Usefulness of determining beta-2-microglobulin in serum and urine in patients with metabolically active kidney calculi and healthy individuals]. 61 54
8170811 1993
4
[The significance of microproteinuria for the diagnosis of kidney involvement in hypertensive disease and secondary forms of arterial hypertension]. 54 61
1440304 1992
5
Atypical focal xanthogranulomatous pyelonephritis without clinical symptoms presenting as infiltrative renal cancer: a case report and literature review. 61
32493295 2020
6
CT imaging of acute and chronic pyelonephritis: a practical guide for emergency radiologists. 61
32445022 2020
7
High-output cardiac failure secondary to high-output arteriovenous fistula: investigations, management and definitive treatment. 61
32111713 2020
8
Clinical, morphologic and histological features of chronic pyelonephritis: An 8-year review. 61
32003360 2020
9
[Features of chronic kidney disease in elderly patients.] 61
32362093 2020
10
Chronic kidney disease in preeclamptic patients: not found unless searched for-Is a nephrology evaluation useful after an episode of preeclampsia? 61
31317437 2019
11
[Predictors of perioperative complications in children with obstructive uropathy]. 61
31808640 2019
12
Squamous cell carcinoma of the renal pelvis presenting as an integumentary neoplasm of the flank: A case report. 61
31490399 2019
13
Xanthogranulomatous Pyelonephritis Causing Renocolic Fistula Presenting as Symptomatic Anemia. 61
31453021 2019
14
A Rare Manifestation of Tuberculosis in a Renal Transplant Patient: A Case Report. 61
31155204 2019
15
Perinephric myxoid pseudotumor of fat: a distinctive pseudoneoplasm most often associated with non-neoplastic renal disease. 61
30826321 2019
16
Renal pyelocalyceal squamous cell carcinoma in a patient with an ectopic kidney presenting with chronic pyelonephritis: a case report. 61
31118085 2019
17
Living-Donor Kidney Transplant in a Patient With Type B Mayer-Rokitansky-Küster-Hauser Syndrome, Reconstructed Vagina, and Abnormal Pelvic Vessels: A Case Report. 61
28540840 2019
18
[Comparative analysis of results in laparoscopic radical cystectomy with extracorporeal and intracorporeal neobladder formation]. 61
31184021 2019
19
Clinical profile of tuberculosis in patients with chronic kidney disease: A report from an endemic Country. 61
31031383 2019
20
Early start of clean intermittent catheterization versus expectant management in children with spina bifida. 61
30558962 2019
21
Spontaneous perirenal hemorrhage (Wunderlich syndrome): An analysis of 28 cases. 61
29779678 2019
22
Neutrophil-to-Lymphocyte Ratio in Renal Cell Carcinoma Patients. 61
31188772 2018
23
[The changes in urine microflora in patients with urinary stone disease]. 61
30742375 2018
24
[Some epidemiological aspects of urinary tract infections in Altai regional hospital for veterans of wars]. 61
30742382 2018
25
Immunohistochemical characteristics of renomedullary interstitial cell tumor: a study of 41 tumors with emphasis on differential diagnosis of mesenchymal neoplasms. 61
30031100 2018
26
Studies on biofilm formation and virulence factors associated with uropathogenic Escherichia coli isolated from patient with acute pyelonephritis. 61
30032909 2018
27
Bear Paw Sign: Xanthogranulomatous Pyelonephritis. 61
30647833 2018
28
EFFECTIVENESS OF NONALCOHOLIC STEATOHEPATITIS CORRECTION ON THE BAСKGROUND OF OBESITY WITH CONCOMITANT CHRONIC KIDNEY DISEASE. 61
30516498 2018
29
[The role of modification of innate immunity in development of premature labore]. 61
30378561 2018
30
[Xanthogranulonatous pyelonephritis: report of 5 cases]. 61
30122783 2018
31
Trends in Urologic Indications for Pediatric Renal Transplantation Over a 27-Year-period United Network for Organ Sharing (UNOS) Database. 61
29154793 2018
32
Primary Squamous Cell Carcinoma of Renal Pelvis in Non-Functioning Kidneys. 61
29866254 2018
33
Bilateral renal abscessation and chronic active pyelonephritis in a male camel (Camelus dromedarius) caused by Escherichia coli. 61
29563349 2018
34
Proteflazid®: treatment of herpesvirus and mixed infections. Meta-analysis of clinical trials results. 61
29813042 2018
35
The pathological evaluation of nonneoplastic kidney disorder in tumor nephrectomy specimens. 61
29970734 2018
36
Surgical and endoscopic treatment of bladder exstrophy-epispadias complex in a female dog. 61
29504860 2018
37
INTENSITY OF THE ANTIOXIDANT PROTECTION SYSTEM AND OXIDATIVE STRESS FACTORS IN PATIENTS WITH NON-ALCOHOLIC STEATOHEPATITIS DEPENDING ON THE FORM OF CHRONIC KIDNEY DISEASE. 61
29697385 2018
38
Bilateral Obstructive Uropathy Caused by Congenital Bladder Diverticulum Presenting as Hypertensive Retinopathy. 61
29441752 2018
39
[Features of urolithiasis in patients of advanced and senile age.] 61
30584876 2018
40
[Features of the proteome of the urine in chronic pyelonephritis.] 61
30720953 2018
41
[Renal tumor or pseudotumoral xanthogranulomatous pyelonephritis]. 61
29875948 2018
42
Urinothorax Caused by Xanthogranulomatous Pyelonephritis. 61
30079257 2018
43
Etiology of Early Renal Allograft Dysfunction and Comparison between Dysfunction and Function Group: A Single Center Study. 61
29208861 2017
44
PECULIARITIES OF REMODELING OF HEART AND NEUROHUMORAL STATUS IN PATIENTS WITH CHRONIC HEART FAILURE AND CONCOMITANT RENAL DISEASE DEPENDING ON THE VALUE OF THE EJECTION FRACTION OF THE LEFT VENTRICLE. 61
28972483 2017
45
Transurethral contact ureterolithotripsy in gas (СО2) medium. 61
28430340 2017
46
Discovery of a novel dominant mutation in the REN gene after forty years of renal disease: a case report. 61
28701203 2017
47
Chronic renal failure: An autopsy study. 61
28540891 2017
48
[Chronic pyelonephritis]. 61
28406593 2017
49
[Technical features of intestinal ureteroplasty. art 6: simultaneous ureteral and bladder substitution]. 61
28394517 2017
50
Are we performing a lot of simple nephrectomies? 61
28303996 2017

Variations for Chronic Pyelonephritis

Expression for Chronic Pyelonephritis

Search GEO for disease gene expression data for Chronic Pyelonephritis.

Pathways for Chronic Pyelonephritis

Pathways related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.7 TLR4 HLA-B HLA-A B2M
2 10.2 HLA-B HLA-A B2M

GO Terms for Chronic Pyelonephritis

Cellular components related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.01 UMOD SERPINA3 HLA-B HLA-A CP B2M
2 cell surface GO:0009986 9.85 UMOD TLR4 HLA-B HLA-A B2M
3 extracellular region GO:0005576 9.85 UMOD SERPINA3 REN CRP CPN1 CP
4 recycling endosome membrane GO:0055038 9.61 HLA-B HLA-A B2M
5 phagocytic vesicle membrane GO:0030670 9.5 HLA-B HLA-A B2M
6 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-B HLA-A B2M
7 MHC class I peptide loading complex GO:0042824 9.37 HLA-A B2M
8 extracellular space GO:0005615 9.32 UMOD SERPINA3 REN CRP CPN1 CP
9 MHC class I protein complex GO:0042612 9.13 HLA-B HLA-A B2M

Biological processes related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 TLR4 HLA-B HLA-A CRP B2M
2 cellular protein metabolic process GO:0044267 9.67 CP CALCA B2M ALB
3 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 9.63 HLA-B HLA-A B2M
4 interferon-gamma-mediated signaling pathway GO:0060333 9.61 HLA-B HLA-A B2M
5 amyloid-beta metabolic process GO:0050435 9.55 REN ACE
6 detection of bacterium GO:0016045 9.52 HLA-B HLA-A
7 angiotensin maturation GO:0002003 9.51 REN ACE
8 regulation of blood pressure GO:0008217 9.5 REN CALCA ACE
9 antigen processing and presentation of endogenous peptide antigen via MHC class I GO:0019885 9.49 HLA-A B2M
10 positive regulation of T cell cytokine production GO:0002726 9.48 HLA-A B2M
11 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 9.4 HLA-B HLA-A
12 positive regulation of T cell mediated cytotoxicity GO:0001916 9.33 HLA-B HLA-A B2M
13 protection from natural killer cell mediated cytotoxicity GO:0042270 9.26 HLA-B HLA-A
14 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 9.13 HLA-B HLA-A B2M
15 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 8.92 HLA-B HLA-A B2M ACE

Molecular functions related to Chronic Pyelonephritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.35 TLR4 REN HLA-B HLA-A CALCA
2 chaperone binding GO:0051087 9.33 HLA-B CP ALB
3 TAP binding GO:0046977 8.62 HLA-B HLA-A

Sources for Chronic Pyelonephritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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