CRMO
MCID: CHR288
MIFTS: 56

Chronic Recurrent Multifocal Osteomyelitis (CRMO)

Categories: Bone diseases, Rare diseases, Skin diseases

Aliases & Classifications for Chronic Recurrent Multifocal Osteomyelitis

MalaCards integrated aliases for Chronic Recurrent Multifocal Osteomyelitis:

Name: Chronic Recurrent Multifocal Osteomyelitis 58 12 77 54 38 45 15
Chronic Multifocal Osteomyelitis 12 54 74
Crmo 58 12 54
Chronic Nonbacterial Osteomyelitis/chronic Recurrent Multifocal Osteomyelitis 54 60
Cno/crmo 54 60
Cmo 58 54
Osteomyelitis, Chronic Multifocal; Cmo 58
Osteomyelitis, Chronic Multifocal 58
Multifocal Osteomyelitis, Chronic 54
Chronic Osteomyelitis 15

Characteristics:

Orphanet epidemiological data:

60
chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Worldwide),1-9/100000 (Worldwide); Age of onset: Adolescent,Childhood; Age of death: normal life expectancy;

OMIM:

58
Inheritance:
? autosomal recessive


HPO:

33
chronic recurrent multifocal osteomyelitis:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Chronic Recurrent Multifocal Osteomyelitis

NIH Rare Diseases : 54 Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory bone condition. Signs and symtpoms include recurrent episodes of pain and joint swelling, with or without fever. Symptoms typically begin in childhood. CRMO may occur alone, with psoriasis or inflammatory bowel disease, or as part of the syndromes, Majeed syndrome or DIRA. For most children, CRMO resolves after many years without lasting effects. However, CRMO can cause slow growth and permanent bone deformity.

MalaCards based summary : Chronic Recurrent Multifocal Osteomyelitis, also known as chronic multifocal osteomyelitis, is related to osteomyelitis and arthritis. An important gene associated with Chronic Recurrent Multifocal Osteomyelitis is LPIN2 (Lipin 2), and among its related pathways/superpathways are Glycerolipid metabolism and Glycerophospholipid metabolism. The drugs Pamidronate and sodium fluoride have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and neutrophil, and related phenotypes are osteomyelitis and bone pain

Disease Ontology : 12 An osteomyelitis characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition to the pelvis, the shoulder girdle and the spine.

Wikipedia : 77 Chronic recurrent multifocal osteomyelitis (CRMO) ("multifocal" because it can erupt in different sites,... more...

Description from OMIM: 259680

Related Diseases for Chronic Recurrent Multifocal Osteomyelitis

Diseases related to Chronic Recurrent Multifocal Osteomyelitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 31.5 FBLIM1 IL1B IL1RN LPIN2
2 arthritis 30.0 IL1B IL1RN PSTPIP1
3 bone inflammation disease 29.9 CRP IL1B IL1RN
4 juvenile rheumatoid arthritis 29.9 CRP IL1B IL1RN
5 synovitis 29.9 CRP IL1B IL1RN
6 suppurative otitis media 29.7 CRP IL1B
7 adult-onset still's disease 29.7 CRP IL1B IL1RN
8 familial mediterranean fever 28.9 CASP1 CRP IL1B IL1RN PSTPIP1
9 majeed syndrome 12.6
10 corticosterone methyloxidase type i deficiency 12.3
11 corticosterone methyloxidase type ii deficiency 12.2
12 corticosterone methyloxidase deficiency 11.1
13 neutrophil migration 10.6
14 blood group, gerbich system 10.3
15 pyoderma 10.3
16 alcoholic gastritis 10.3 CASP1 IL1B
17 familial cold autoinflammatory syndrome 10.3 CASP1 IL1B
18 familial cold autoinflammatory syndrome 1 10.3 CASP1 IL1B
19 streptococcal group a invasive disease 10.2
20 crohn's disease 10.2
21 lymphoma 10.2
22 sapho syndrome 10.2
23 calcinosis 10.2
24 pyoderma gangrenosum 10.2
25 psoriasis 10.2
26 vulvar vestibulitis syndrome 10.2 IL1B IL1RN
27 osteosclerotic myeloma 10.2 IL1B IL1RN
28 meningococcemia 10.2 IL1B IL1RN
29 hydrarthrosis 10.2 IL1B IL1RN
30 wells syndrome 10.2 CRP IL1B
31 ulcerative colitis 10.2
32 colitis 10.2
33 aseptic meningitis 10.2 IL1B IL1RN
34 joint disorders 10.2 IL1B IL1RN
35 root resorption 10.1 IL1B IL1RN
36 extrapulmonary tuberculosis 10.1 IL1B IL1RN
37 pericoronitis 10.1 CRP IL1B
38 uremic pruritus 10.1 CRP IL1B
39 ulceroglandular tularemia 10.1 CASP1 CRP
40 dengue shock syndrome 10.1 IL1B IL1RN
41 central nervous system vasculitis 10.1 CRP IL1B
42 paratyphoid fever 10.1 CASP1 CRP
43 aphthous stomatitis 10.1 IL1B IL1RN
44 pharyngitis 10.1 CRP IL1B
45 scrub typhus 10.1 CRP IL1B
46 idiopathic neutropenia 10.1 IL1B IL1RN
47 neuroblastoma 1 10.1
48 autoimmune progesterone dermatitis 10.1
49 hydroa vacciniforme 10.1
50 neurofibromatosis, type ii 10.1

Graphical network of the top 20 diseases related to Chronic Recurrent Multifocal Osteomyelitis:



Diseases related to Chronic Recurrent Multifocal Osteomyelitis

Symptoms & Phenotypes for Chronic Recurrent Multifocal Osteomyelitis

Human phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

60 33 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 osteomyelitis 60 33 very rare (1%) Very frequent (99-80%) HP:0002754
2 bone pain 60 33 very rare (1%) Very frequent (99-80%) HP:0002653
3 hyperostosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100774
4 abnormality of epiphysis morphology 60 33 frequent (33%) Frequent (79-30%) HP:0005930
5 arthritis 60 33 frequent (33%) Frequent (79-30%) HP:0001369
6 abnormal vertebral morphology 60 33 frequent (33%) Frequent (79-30%) HP:0003468
7 fatigue 60 33 frequent (33%) Frequent (79-30%) HP:0012378
8 edema 60 33 frequent (33%) Frequent (79-30%) HP:0000969
9 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
10 abnormality of the metaphysis 60 33 frequent (33%) Frequent (79-30%) HP:0000944
11 osteolysis 60 33 frequent (33%) Frequent (79-30%) HP:0002797
12 elevated c-reactive protein level 60 33 frequent (33%) Frequent (79-30%) HP:0011227
13 elevated erythrocyte sedimentation rate 60 33 very rare (1%) Frequent (79-30%) HP:0003565
14 poor appetite 60 33 frequent (33%) Frequent (79-30%) HP:0004396
15 craniofacial osteosclerosis 60 33 frequent (33%) Frequent (79-30%) HP:0005464
16 scoliosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002650
17 fever 60 33 very rare (1%) Occasional (29-5%) HP:0001945
18 cranial nerve paralysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0006824
19 anemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001903
20 pruritus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000989
21 acne 60 33 occasional (7.5%) Occasional (29-5%) HP:0001061
22 inflammation of the large intestine 60 33 occasional (7.5%) Occasional (29-5%) HP:0002037
23 skin rash 60 33 occasional (7.5%) Occasional (29-5%) HP:0000988
24 vasculitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002633
25 abnormality of the sacroiliac joint 60 33 occasional (7.5%) Occasional (29-5%) HP:0100781
26 psoriasiform dermatitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0003765
27 palmoplantar pustulosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100847

Symptoms via clinical synopsis from OMIM:

58
Skel:
chronic recurrent multifocal osteomyelitis
long bone metaphyses predominantly involved

Lab:
no pathogens isolated from affected areas
subacute and chronic inflammatory histologic features

Clinical features from OMIM:

259680

MGI Mouse Phenotypes related to Chronic Recurrent Multifocal Osteomyelitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 ALPL ARID3A CASP1 FBLIM1 IL1B IL1RN
2 cardiovascular system MP:0005385 9.8 ALPL ARID3A CASP1 CRP IL1B IL1RN
3 homeostasis/metabolism MP:0005376 9.56 ALPL CASP1 CPT1B CRP IL1B IL1RN
4 immune system MP:0005387 9.32 ALPL ARID3A CASP1 CRP FBLIM1 IL1B

Drugs & Therapeutics for Chronic Recurrent Multifocal Osteomyelitis

Drugs for Chronic Recurrent Multifocal Osteomyelitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pamidronate Approved Phase 2 40391-99-9 4674
2 sodium fluoride Approved Not Applicable 7681-49-4
3 Fluorides Not Applicable
4 Listerine Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
2 Chronic Recurrent Multifocal Osteomyelitis - a Bacterial Cause? Recruiting NCT03433287 Not Applicable
3 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168

Search NIH Clinical Center for Chronic Recurrent Multifocal Osteomyelitis

Cochrane evidence based reviews: chronic recurrent multifocal osteomyelitis

Genetic Tests for Chronic Recurrent Multifocal Osteomyelitis

Anatomical Context for Chronic Recurrent Multifocal Osteomyelitis

MalaCards organs/tissues related to Chronic Recurrent Multifocal Osteomyelitis:

42
Bone, Skin, Neutrophil, Heart, Monocytes, Testes, Spinal Cord

Publications for Chronic Recurrent Multifocal Osteomyelitis

Articles related to Chronic Recurrent Multifocal Osteomyelitis:

(show top 50) (show all 252)
# Title Authors Year
1
Evolution of chronic recurrent multifocal osteomyelitis in a child shown by MRI. ( 30364530 )
2019
2
The Dilemma of Chronic Recurrent Multifocal Osteomyelitis. ( 30616941 )
2019
3
Chronic recurrent multifocal osteomyelitis-case report of two patients and review of literature. ( 31031824 )
2019
4
New-Onset Chronic Recurrent Multifocal Osteomyelitis in a Child With Chronic Uveitis. ( 31034088 )
2019
5
Idiopathic CRMO and MEFV Gene Variant Alleles: Is There Any Relationship? ( 31049240 )
2019
6
Cat-Scratch Disease, a Diagnostic Consideration for Chronic Recurrent Multifocal Osteomyelitis. ( 29239936 )
2018
7
Chronic Recurrent Multifocal Osteomyelitis in Crohn Disease: Complete Resolution With Anti-TNFα Therapy. ( 27050047 )
2018
8
Chronic recurrent multifocal osteomyelitis in children and adults: current understanding and areas for development. ( 28486628 )
2018
9
Complete resolution and remodeling of chronic recurrent multifocal osteomyelitis on MRI and radiographs. ( 29124297 )
2018
10
Biologic treatment for chronic recurrent multifocal osteomyelitis: report of four cases and review of the literature. ( 29127574 )
2018
11
Chronic recurrent multifocal osteomyelitis: a case report. ( 29454377 )
2018
12
Bone inflammation and chronic recurrent multifocal osteomyelitis. ( 29565497 )
2018
13
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29596638 )
2018
14
Chronic Recurrent Multifocal Osteomyelitis of the Mandible: A Diagnostic Challenge. ( 29652766 )
2018
15
The multifaceted presentation of chronic recurrent multifocal osteomyelitis: a series of 486 cases from the Eurofever international registry. ( 29718410 )
2018
16
Chronic recurrent multifocal osteomyelitis in pediatrics: A diagnostic challenge. ( 29776891 )
2018
17
The role of whole-body magnetic resonance imaging in diagnosing chronic recurrent multifocal osteomyelitis. ( 29904495 )
2018
18
Chronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children. ( 30031498 )
2018
19
Unusual case of chronic recurrent multifocal osteomyelitis. ( 30053822 )
2018
20
Chronic recurrent multifocal osteomyelitis (CRMO) involving spine: A case report and literature review. ( 30153963 )
2018
21
Case series of psoriasis associated with tumor necrosis factor-α inhibitors in children with chronic recurrent multifocal osteomyelitis. ( 30246121 )
2018
22
Characteristic Radiographic Appearance of Chronic Recurrent Multifocal Osteomyelitis. ( 30363000 )
2018
23
Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome - Two Presentations of the Same Disease? ( 30390722 )
2018
24
Chronic recurrent multifocal osteomyelitis with psoriatic skin manifestations in a 12-year-old female. ( 30479859 )
2018
25
Chronic Recurrent Multifocal Osteomyelitis - A Case Series from India. ( 30532310 )
2018
26
Concurrent chronic recurrent multifocal osteomyelitis and familial Mediterranean fever. A case report. ( 30582505 )
2018
27
Chronic Recurrent Multifocal Osteomyelitis - A Rare Clinical Presentation and Review of Literature. ( 30584505 )
2018
28
SAPHO and CRMO: The Value of Imaging. ( 29672809 )
2018
29
Chronic recurrent multifocal osteomyelitis complicated by hip subluxation: a case report. ( 25123421 )
2017
30
Successful treatment of chronic recurrent multifocal osteomyelitis using low-dose radiotherapy : A case report. ( 27822735 )
2017
31
An Unusual Association of Chronic Recurrent Multifocal Osteomyelitis, Pyoderma Gangrenosum, and Takayasu Arteritis. ( 28042129 )
2017
32
Classical Hodgkin lymphoma masquerading as chronic recurrent multifocal osteomyelitis: a case report. ( 28212666 )
2017
33
Paediatric chronic recurrent multifocal osteomyelitis. ( 28280083 )
2017
34
Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO). ( 28301468 )
2017
35
Chronic Recurrent Multifocal Osteomyelitis and Related Diseases-Update on Pathogenesis. ( 28361334 )
2017
36
An Update on the Pathogenesis and Treatment of Chronic Recurrent Multifocal Osteomyelitis in Children. ( 28401420 )
2017
37
Oral alendronate in pediatric chronic recurrent multifocal osteomyelitis. ( 28401741 )
2017
38
Chronic recurrent multifocal osteomyelitis beginning with a solitary lesion of the ilium. ( 28587611 )
2017
39
Chronic recurrent multifocal osteomyelitis presenting with Tolosa-Hunt syndrome in a 13-year-old boy. ( 28598320 )
2017
40
Chronic recurrent multifocal osteomyelitis exhibiting predominance of periosteal reaction. ( 28614530 )
2017
41
Chronic Recurrent Multifocal Osteomyelitis: A Case Report with Atypical Presentation. ( 28630846 )
2017
42
Chronic Recurrent Multifocal Osteomyelitis in a 9-year-old Boy. ( 28656169 )
2017
43
Utility of Three-phase Skeletal Scintigraphy with Single Photon Emission Computed Tomography/Computed Tomography in a Case of Chronic Recurrent Multifocal Osteomyelitis. ( 28680224 )
2017
44
Correction: Recessive coding and regulatory mutations in FBLIM1 underlie the pathogenesis of chronic recurrent multifocal osteomyelitis (CRMO). ( 28686717 )
2017
45
Adult-onset Chronic Recurrent Multifocal Osteomyelitis with High Intensity of Muscles Detected by Magnetic Resonance Imaging, Successfully Controlled with Tocilizumab. ( 28794369 )
2017
46
Chronic recurrent multifocal osteomyelitis: a case report. ( 29062831 )
2017
47
Chronic Recurrent Multifocal Osteomyelitis (CRMO): Presentation, Pathogenesis, and Treatment. ( 29080202 )
2017
48
Chronic Recurrent Multifocal Osteomyelitis and Thalidomide in Chronic Granulomatous Disease. ( 27436506 )
2016
49
Whole-Body Diffusion-Weighted Imaging in Chronic Recurrent Multifocal Osteomyelitis in Children. ( 26799970 )
2016
50
Serum biomarkers for the diagnosis and monitoring of chronic recurrent multifocal osteomyelitis (CRMO). ( 27000045 )
2016

Variations for Chronic Recurrent Multifocal Osteomyelitis

ClinVar genetic disease variations for Chronic Recurrent Multifocal Osteomyelitis:

6 (show all 16)
# Gene Variation Type Significance SNP ID Assembly Location
1 TERT NM_198253.2(TERT): c.1951-205G> A single nucleotide variant Benign rs10069690 GRCh38 Chromosome 5, 1279675: 1279675
2 TERT NM_198253.2(TERT): c.1951-205G> A single nucleotide variant Benign rs10069690 GRCh37 Chromosome 5, 1279790: 1279790
3 ACYP2 NM_001320586.1(ACYP2): c.405-55959C> A single nucleotide variant association rs11125529 GRCh38 Chromosome 2, 54248729: 54248729
4 ACYP2 NM_001320586.1(ACYP2): c.405-55959C> A single nucleotide variant association rs11125529 GRCh37 Chromosome 2, 54475866: 54475866
5 MYNN NM_018657.4(MYNN): c.18C> T (p.His6=) single nucleotide variant association rs10936599 GRCh38 Chromosome 3, 169774313: 169774313
6 MYNN NM_018657.4(MYNN): c.18C> T (p.His6=) single nucleotide variant association rs10936599 GRCh37 Chromosome 3, 169492101: 169492101
7 NC_000004.12: g.163086668A> G single nucleotide variant association rs7675998 GRCh38 Chromosome 4, 163086668: 163086668
8 NC_000004.12: g.163086668A> G single nucleotide variant association rs7675998 GRCh37 Chromosome 4, 164007820: 164007820
9 TERT NM_198253.2(TERT): c.1574-3777G> T single nucleotide variant association rs2736100 GRCh38 Chromosome 5, 1286401: 1286401
10 TERT NM_198253.2(TERT): c.1574-3777G> T single nucleotide variant association rs2736100 GRCh37 Chromosome 5, 1286516: 1286516
11 TERT NM_198253.2(TERT): c.-1382T> C single nucleotide variant association rs2735940 GRCh38 Chromosome 5, 1296371: 1296371
12 TERT NM_198253.2(TERT): c.-1382T> C single nucleotide variant association rs2735940 GRCh37 Chromosome 5, 1296486: 1296486
13 NC_000014.9: g.56058851G> A single nucleotide variant association rs398652 GRCh37 Chromosome 14, 56525569: 56525569
14 NC_000014.9: g.56058851G> A single nucleotide variant association rs398652 GRCh38 Chromosome 14, 56058851: 56058851
15 ZBTB46 NM_025224.3(ZBTB46): c.489T> C (p.Ala163=) single nucleotide variant association rs755017 GRCh38 Chromosome 20, 63790269: 63790269
16 ZBTB46 NM_025224.3(ZBTB46): c.489T> C (p.Ala163=) single nucleotide variant association rs755017 GRCh37 Chromosome 20, 62421622: 62421622

Expression for Chronic Recurrent Multifocal Osteomyelitis

Search GEO for disease gene expression data for Chronic Recurrent Multifocal Osteomyelitis.

Pathways for Chronic Recurrent Multifocal Osteomyelitis

Pathways related to Chronic Recurrent Multifocal Osteomyelitis according to KEGG:

38
# Name Kegg Source Accession
1 Glycerolipid metabolism hsa00561
2 Glycerophospholipid metabolism hsa00564

Pathways related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 CASP1 IL1B PSTPIP1 PYCARD
2
Show member pathways
11.98 CASP1 IL1B IL1RN
3
Show member pathways
11.89 CASP1 IL1B PYCARD
4
Show member pathways
11.87 CASP1 IL1B PYCARD
5 11.7 ARID3A CASP1 PYCARD
6
Show member pathways
11.6 CASP1 PSTPIP1 PYCARD
7 11.43 CASP1 IL1B PYCARD
8 11.31 CASP1 IL1B PYCARD
9 10.87 CASP1 IL1B PYCARD
10 10.78 CASP1 IL1B
11 10.41 CASP1 IL1B PYCARD
12 10 CASP1 IL1B

GO Terms for Chronic Recurrent Multifocal Osteomyelitis

Cellular components related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NLRP3 inflammasome complex GO:0072559 9.16 CASP1 PYCARD
2 NLRP1 inflammasome complex GO:0072558 8.96 CASP1 PYCARD
3 AIM2 inflammasome complex GO:0097169 8.62 CASP1 PYCARD

Biological processes related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.63 CASP1 IL1B IL1RN
2 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.54 CASP1 PYCARD
3 positive regulation of JNK cascade GO:0046330 9.54 IL1B IL1RN PYCARD
4 positive regulation of interferon-gamma production GO:0032729 9.52 IL1B PYCARD
5 cellular response to organic substance GO:0071310 9.51 CASP1 IL1B
6 positive regulation of phagocytosis GO:0050766 9.49 IL1B PYCARD
7 positive regulation of interleukin-1 beta secretion GO:0050718 9.48 CASP1 PYCARD
8 positive regulation of interleukin-6 secretion GO:2000778 9.43 IL1B PYCARD
9 positive regulation of interleukin-6 production GO:0032755 9.33 IL1B IL1RN PYCARD
10 response to glucocorticoid GO:0051384 9.32 ALPL IL1RN
11 interleukin-1 beta production GO:0032611 9.26 IL1B PYCARD
12 cellular response to lipopolysaccharide GO:0071222 9.26 CASP1 IL1B IL1RN PYCARD
13 response to vitamin D GO:0033280 9.1 ALPL
14 inflammatory response GO:0006954 9.02 CRP IL1B IL1RN PSTPIP1 PYCARD

Molecular functions related to Chronic Recurrent Multifocal Osteomyelitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activator activity involved in apoptotic process GO:0008656 9.16 CASP1 PYCARD
2 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 8.96 CASP1 PYCARD
3 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Chronic Recurrent Multifocal Osteomyelitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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