MCID: CHR048
MIFTS: 40

Chronic Rhinitis

Categories: Bone diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Chronic Rhinitis

MalaCards integrated aliases for Chronic Rhinitis:

Name: Chronic Rhinitis 12 56 15 74
Rhinitis - Chronic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8252
ICD9CM 36 472.0
NCIt 51 C34479
SNOMED-CT 69 86094006
ICD10 34 J31.0
UMLS 74 C0008711

Summaries for Chronic Rhinitis

Disease Ontology : 12 A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

MalaCards based summary : Chronic Rhinitis, also known as rhinitis - chronic, is related to rhinitis and pharyngitis, and has symptoms including rhinorrhea, purulent rhinitis and catarrh. An important gene associated with Chronic Rhinitis is EDN1 (Endothelin 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Endothelin Pathways. The drugs Capsaicin and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Rhinitis

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Chronic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 rhinitis 10.8
2 pharyngitis 10.7
3 nasopharyngitis 10.3
4 sinusitis 10.2
5 asthma 10.1
6 idiopathic edema 10.1 EDN1 MPO
7 eosinophil peroxidase deficiency 10.1 EPX MPO
8 collagenous colitis 10.0 EPX MPO
9 proctitis 10.0 EPX MPO
10 orthostatic intolerance 10.0 ECE1 EDN1
11 vernal conjunctivitis 10.0 EPX MPO
12 maxillary sinusitis 9.9 MPO RHNO1
13 allergic rhinitis 9.9
14 hypereosinophilic syndrome 9.9
15 headache 9.9
16 chronic maxillary sinusitis 9.9 MPO RHNO1
17 vasomotor rhinitis 9.8
18 atrophic rhinitis 9.8
19 leukemia, chronic lymphocytic 2 9.8
20 ige responsiveness, atopic 9.8
21 leukemia, chronic lymphocytic 9.8
22 otitis media 9.8
23 leprosy 3 9.8
24 acute insulin response 9.8
25 pulmonary disease, chronic obstructive 9.8
26 leukemia 9.8
27 lymphoma 9.8
28 adenoid hypertrophy 9.8
29 lymphocytic leukemia 9.8
30 rhinoscleroma 9.8
31 laryngitis 9.8
32 bronchitis 9.8
33 fibromyalgia 9.8
34 hansen's disease 9.8
35 leukemia, b-cell, chronic 9.8
36 precursor t-cell acute lymphoblastic leukemia 9.7 ASNS MPO
37 dermatitis, atopic 9.7
38 urticaria 9.7
39 dermatitis 9.7

Comorbidity relations with Chronic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Rhinitis:



Diseases related to Chronic Rhinitis

Symptoms & Phenotypes for Chronic Rhinitis

UMLS symptoms related to Chronic Rhinitis:


rhinorrhea, purulent rhinitis, catarrh

GenomeRNAi Phenotypes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

27 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 ASNS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.7 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 EDN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.7 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 ASNS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.7 ASNS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 ASNS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.7 ASNS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 ASNS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 EDN1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.7 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 EDN1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.7 ASNS MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 ASNS EDN1 MPO
21 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.7 EDN1

Drugs & Therapeutics for Chronic Rhinitis

Drugs for Chronic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
3 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
4 Dermatologic Agents Phase 4
5 Antipruritics Phase 4
6 Anti-Allergic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4,Phase 3
8 Pharmaceutical Solutions Phase 3
9 Hormones Phase 3
10 Respiratory System Agents Phase 3,Phase 2,Not Applicable
11 Antibiotics, Antitubercular Phase 3
12 glucocorticoids Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Anti-Infective Agents Phase 3
15 Anti-Asthmatic Agents Phase 3
16 Hormone Antagonists Phase 3
17
Beclomethasone Phase 3 4419-39-0 20469
18 Anti-Bacterial Agents Phase 3
19
Pseudoephedrine Approved Phase 2,Not Applicable 90-82-4 7028
20
Ephedrine Approved Phase 2,Not Applicable 299-42-3 9294
21
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
22 Ginkgo Phase 2
23 Autonomic Agents Phase 2,Not Applicable
24 Neurotransmitter Agents Phase 2,Not Applicable
25 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
26 Appetite Depressants Phase 2
27 Sympathomimetics Phase 2,Not Applicable
28 Vasoconstrictor Agents Phase 2,Not Applicable
29 Anti-Obesity Agents Phase 2
30 Nasal Decongestants Phase 2,Not Applicable
31 Adrenergic Agonists Phase 2,Not Applicable
32 Expectorants Phase 2
33 Adrenergic Agents Phase 2,Not Applicable
34
Chlorpheniramine Phase 2 113-92-8, 132-22-9 2725
35 Adrenergic alpha-Agonists Phase 2,Not Applicable
36
Racepinephrine Approved Not Applicable 329-65-7 838
37
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
38
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
39
Nitric Oxide Approved 10102-43-9 145068
40
Phenylephrine Approved Not Applicable 59-42-7 6041
41
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
42
Pomegranate Experimental, Investigational
43 Anesthetics Not Applicable
44 Epinephryl borate Not Applicable
45 Free Radical Scavengers
46 Endothelium-Dependent Relaxing Factors
47 Antioxidants
48 Bronchodilator Agents
49 Vasodilator Agents
50 Protective Agents ,Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
2 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
3 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
4 Surgical Reduction of the Inferior Turbinates for Nasal Obstruction Terminated NCT00737906 Phase 4
5 Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
6 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
7 beCLomethasone Efficacy in Acute Rhinosinusitis - CLEAR Study Completed NCT01691677 Phase 3 beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days;placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days
8 Role of Ginkgo Biloba Extract in IUGR Completed NCT02425436 Phase 2 Ginkgo Biloba Extract
9 The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Recruiting NCT01364467 Phase 2 Placebo;Guaifenesin
10 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis Unknown status NCT01564849
11 A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Rhinorrhea. Unknown status NCT01546662 Not Applicable
12 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Completed NCT02000648
13 A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction Completed NCT01054521 Not Applicable
14 ClariFix Cryoablation Clinical Study Completed NCT02820597 Not Applicable
15 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866
16 Protocol TARC-ABPA Completed NCT01710930 Not Applicable
17 Posterior Nasal Nerve (PNN) Rhinitis Study Recruiting NCT03727347 Not Applicable
18 Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation Recruiting NCT03893227
19 Multi-Treatment PNN Modulation for Chronic Rhinitis Active, not recruiting NCT03791489 Not Applicable
20 Evaluation of the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis Active, not recruiting NCT03181594 Not Applicable
21 Registry of Subject Treated With ClariFix Active, not recruiting NCT03739216
22 Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion Terminated NCT00584662 Not Applicable Oxymetazoline Hydrochloride

Search NIH Clinical Center for Chronic Rhinitis

Genetic Tests for Chronic Rhinitis

Anatomical Context for Chronic Rhinitis

MalaCards organs/tissues related to Chronic Rhinitis:

42
Bone, Testes, Skin, B Cells, Thyroid, T Cells

Publications for Chronic Rhinitis

Articles related to Chronic Rhinitis:

(show top 50) (show all 144)
# Title Authors Year
1
Prevalence of local allergic rhinitis to Dermatophagoides pteronyssinus in chronic rhinitis with negative skin prick test. ( 30903999 )
2019
2
Chronic Rhinitis Is a High-Risk Comorbidity for 30-Day Hospital Readmission of Patients with Asthma and Chronic Obstructive Pulmonary Disease. ( 30053594 )
2019
3
Endotypes of chronic rhinitis: A cluster analysis study. ( 30353934 )
2019
4
Bilateral pararhinotomy with middle meatal antrostomy of the maxillary sinus in a rabbit (Oryctolagus cuniculus) with chronic rhinitis. ( 31067176 )
2019
5
Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis. ( 30253652 )
2018
6
Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants. ( 30285942 )
2018
7
Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations. ( 29497453 )
2018
8
Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis. ( 29568342 )
2018
9
Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta-analysis. ( 30054985 )
2018
10
Therapeutic effect of chlorpheniramine in treatingupper airway cough syndrome (UACS) and chronic rhinitis/sinusitis. ( 30203761 )
2018
11
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. ( 30229670 )
2018
12
Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis. ( 30506053 )
2018
13
Blood eosinophils may predict radiographic sinus opacification in patients with chronic rhinitis. ( 30576087 )
2018
14
Diagnostic Utility of Urinary LTE4 in Asthma, Allergic Rhinitis, Chronic Rhinosinusitis, Nasal Polyps, and Aspirin Sensitivity. ( 27080204 )
2016
15
Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and α-defensins. ( 26831845 )
2016
16
The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: A randomised controlled trial. ( 26994623 )
2016
17
Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis. ( 27746841 )
2016
18
Increased proportions of CCR4(+) cells among peripheral blood CD4(+) cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis. ( 25650058 )
2015
19
Allergic rhinitis, chronic rhinosinusitis and nasal polyposis in Asia Pacific: impact on quality of life and sleep. ( 25097847 )
2014
20
Bronchial asthma control after argon plasma coagulation turbinectomy in patients with chronic rhinitis. ( 24141470 )
2014
21
Chronic rhinitis in the cat. ( 24268332 )
2014
22
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: results of the American Migraine Prevalence and Prevention (AMPP) Study. ( 24275145 )
2014
23
Combined radiofrequency volumetric tissue reduction and lateral outfracture of hypertrophic inferior turbinate in the treatment of chronic rhinitis: short-term and long-term outcome. ( 24415652 )
2014
24
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. ( 24607046 )
2014
25
Radiofrequency inferior turbinate reduction improves smell ability of patients with chronic rhinitis and inferior turbinate hypertrophy. ( 24612902 )
2014
26
Correlation between skin-prick testing, individual specific IgE tests, and a multiallergen IgE assay for allergy detection in patients with chronic rhinitis. ( 25198024 )
2014
27
A study of the role of different forms of chronic rhinitis in the development of otitis media with effusion in children affected by adenoid hypertrophy. ( 24113158 )
2013
28
Allergic rhinitis, chronic rhinosinusitis and asthma: unravelling a complex relationship. ( 23241653 )
2013
29
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. ( 23346908 )
2013
30
Correlation between skin prick test and MAST-immunoblot results in patients with chronic rhinitis. ( 23517390 )
2013
31
Chronic rhinitis in South Africa: update 2013. ( 23725964 )
2013
32
The peculiarities of different types of chronic rhinitis in children and adolescents in Kazakhstan. ( 23785676 )
2013
33
Prevalence of chronic rhinitis in Thai patients with obstructive sleep disordered breathing. ( 24163993 )
2013
34
A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. ( 24654314 )
2013
35
Changes in the prevalence of asthma and chronic rhinitis in Valencia, Spain: the ORBA project 1983-2003. ( 24654316 )
2013
36
Allergic rhinitis, chronic rhinosinusitis, and symptom severity: a population-based study. ( 22311842 )
2012
37
Improvement of chronic rhinitis under aspirin. ( 22005504 )
2012
38
Vitamin D and chronic rhinitis. ( 22193052 )
2012
39
Chronic rhinitis in HTLV-1 carriers: a histopathologic study. ( 22499368 )
2012
40
Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. ( 22521235 )
2012
41
Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. ( 22920071 )
2012
42
Should we perform objective assessment of nasal obstruction in children with chronic rhinitis? ( 23093004 )
2012
43
Differences in airway inflammation according to atopic status in patients with chronic rhinitis. ( 23130330 )
2012
44
Chronic rhinitis: a manifestation of leprosy. ( 21938685 )
2011
45
Epidemiological analysis of chronic rhinitis in pediatric patients. ( 22186247 )
2011
46
Chronic rhinitis due to Streptococcus equi subspecies zooepidemicus in a dog. ( 20675628 )
2010
47
Quality of life in patients with chronic rhinitis after radiofrequency inferior turbinate reduction. ( 20718172 )
2010
48
Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis. ( 18805880 )
2009
49
Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis. ( 19220164 )
2009
50
Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. ( 19720248 )
2009

Variations for Chronic Rhinitis

Expression for Chronic Rhinitis

Search GEO for disease gene expression data for Chronic Rhinitis.

Pathways for Chronic Rhinitis

Pathways related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 ECE1 EDN1
2 10.15 ECE1 EDN1

GO Terms for Chronic Rhinitis

Cellular components related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 ECE1 EDN1

Biological processes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.37 EPX MPO
2 response to mechanical stimulus GO:0009612 9.32 ASNS MPO
3 response to amino acid GO:0043200 9.26 ASNS EDN1
4 hydrogen peroxide catabolic process GO:0042744 9.16 EPX MPO
5 regulation of vasoconstriction GO:0019229 8.96 ECE1 EDN1
6 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.62 ECE1 EDN1

Molecular functions related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 EPX MPO

Sources for Chronic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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