MCID: CHR048
MIFTS: 40

Chronic Rhinitis

Categories: Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Chronic Rhinitis

MalaCards integrated aliases for Chronic Rhinitis:

Name: Chronic Rhinitis 12 55 15 73
Rhinitis - Chronic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8252
ICD10 33 J31.0
ICD9CM 35 472.0
NCIt 50 C34479
UMLS 73 C0008711

Summaries for Chronic Rhinitis

Disease Ontology : 12 A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

MalaCards based summary : Chronic Rhinitis, also known as rhinitis - chronic, is related to asthma and rhinitis, and has symptoms including purulent rhinitis, rhinorrhea and catarrh. An important gene associated with Chronic Rhinitis is EDN1 (Endothelin 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Endothelin Pathways. The drugs Capsaicin and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Rhinitis

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Chronic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 asthma 28.8 EDN1 EPX MPO TRPV1
2 rhinitis 10.7
3 pharyngitis 10.6
4 nasopharyngitis 10.5
5 idiopathic edema 10.4 EDN1 MPO
6 eosinophil peroxidase deficiency 10.3 EPX MPO
7 orthostatic intolerance 10.3 ECE1 EDN1
8 collagenous colitis 10.3 EPX MPO
9 proctitis 10.3 EPX MPO
10 vernal conjunctivitis 10.2 EPX MPO
11 mononeuropathy 10.2 MPO TRPV1
12 bronchial disease 10.1 EPX TRPV1
13 urinary system disease 10.0 EDN1 TRPV1
14 sinusitis 10.0
15 arteries, anomalies of 10.0 EDN1 TRPV1
16 intestinal disease 10.0 MPO TRPV1
17 maxillary sinusitis 9.8 MPO RHNO1
18 allergic hypersensitivity disease 9.8 EPX TRPV1
19 headache 9.8
20 chronic maxillary sinusitis 9.8 MPO RHNO1
21 ischemia 9.8 EDN1 MPO TRPV1
22 multiple cranial nerve palsy 9.8 MPO RHNO1
23 nasal cavity disease 9.7 RHNO1 TRPV1
24 leukemia, chronic lymphocytic 2 9.6
25 leukemia, chronic lymphocytic 9.6
26 otitis media 9.6
27 allergic rhinitis 9.6
28 leukemia 9.6
29 adenoiditis 9.6
30 lymphoma 9.6
31 adenoid hypertrophy 9.6
32 rhinoscleroma 9.6
33 hypothyroidism 9.6
34 laryngitis 9.6
35 sleep disorder 9.6
36 bronchitis 9.6
37 thyroiditis 9.6
38 leukemia, b-cell, chronic 9.6
39 nose disease 9.6 RHNO1 TRPV1
40 upper respiratory tract disease 9.6 RHNO1 TRPV1
41 precursor t-cell acute lymphoblastic leukemia 9.5 ASNS MPO
42 gastrointestinal system disease 9.4 MPO TRPV1
43 respiratory system disease 9.2 MPO RHNO1 TRPV1

Comorbidity relations with Chronic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Rhinitis:



Diseases related to Chronic Rhinitis

Symptoms & Phenotypes for Chronic Rhinitis

UMLS symptoms related to Chronic Rhinitis:


purulent rhinitis, rhinorrhea, catarrh

GenomeRNAi Phenotypes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 ASNS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.7 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 EDN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.7 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 ASNS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.7 ASNS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 ASNS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.7 ASNS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 ASNS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 EDN1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.7 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 EDN1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.7 ASNS MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 ASNS EDN1 MPO
21 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.7 EDN1

Drugs & Therapeutics for Chronic Rhinitis

Drugs for Chronic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2 Dermatologic Agents Phase 4
3 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
4 Antipruritics Phase 4
5 mometasone furoate Phase 4
6 Anti-Allergic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4,Phase 3
8
Beclomethasone Phase 3 4419-39-0 20469
9 glucocorticoids Phase 3
10 Respiratory System Agents Phase 3,Phase 2,Not Applicable
11 Hormone Antagonists Phase 3
12 Hormones Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Anti-Asthmatic Agents Phase 3
15 Anti-Bacterial Agents Phase 3
16 Antibiotics, Antitubercular Phase 3
17 Pharmaceutical Solutions Phase 3
18
Ephedrine Approved Phase 2,Not Applicable 299-42-3 9294
19
Pseudoephedrine Approved Phase 2,Not Applicable 90-82-4 7028
20
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
21 Neurotransmitter Agents Phase 2,Not Applicable
22 Autonomic Agents Phase 2,Not Applicable
23
Chlorpheniramine Phase 2 113-92-8, 132-22-9 2725
24 Adrenergic Agents Phase 2,Not Applicable
25 Adrenergic Agonists Phase 2,Not Applicable
26 Adrenergic alpha-Agonists Phase 2,Not Applicable
27 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
28 Nasal Decongestants Phase 2,Not Applicable
29 Vasoconstrictor Agents Phase 2,Not Applicable
30 Expectorants Phase 2
31 Anti-Obesity Agents Phase 2
32 Appetite Depressants Phase 2
33 Ginkgo Nutraceutical Phase 2
34
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
35
Nitric Oxide Approved 10102-43-9 145068 160954
36
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
37
Racepinephrine Approved Not Applicable 329-65-7 838
38
Phenylephrine Approved Not Applicable 59-42-7 6041
39
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
40 Anesthetics Not Applicable
41 Vasodilator Agents
42 Endothelium-Dependent Relaxing Factors
43 Epinephryl borate Not Applicable
44 Antioxidants
45 Protective Agents ,Not Applicable
46 Bronchodilator Agents
47 Mydriatics Not Applicable
48 Pomegranate Nutraceutical

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
2 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
3 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
4 Surgical Reduction of the Inferior Turbinates for Nasal Obstruction Terminated NCT00737906 Phase 4
5 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
6 beCLomethasone Efficacy in Acute Rhinosinusitis - CLEAR Study Completed NCT01691677 Phase 3 beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days;placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days
7 Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Recruiting NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
8 Role of Ginkgo Biloba Extract in IUGR Completed NCT02425436 Phase 2 Ginkgo Biloba Extract
9 The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Recruiting NCT01364467 Phase 2 Placebo;Guaifenesin
10 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Unknown status NCT02000648
11 A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Unknown status NCT01546662 Not Applicable
12 A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction Completed NCT01054521 Not Applicable
13 ClariFix Cryoablation Clinical Study Completed NCT02820597 Not Applicable
14 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866
15 Protocol TARC-ABPA Completed NCT01710930 Not Applicable
16 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis Recruiting NCT01564849
17 Evaluation of the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis Active, not recruiting NCT03181594 Not Applicable
18 Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion Terminated NCT00584662 Not Applicable Oxymetazoline Hydrochloride

Search NIH Clinical Center for Chronic Rhinitis

Genetic Tests for Chronic Rhinitis

Anatomical Context for Chronic Rhinitis

MalaCards organs/tissues related to Chronic Rhinitis:

41
Bone, Testes, Skin, B Cells, Thyroid

Publications for Chronic Rhinitis

Articles related to Chronic Rhinitis:

(show top 50) (show all 125)
# Title Authors Year
1
Gene and protein expression of <i>CXCR4</i> in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations. ( 29497453 )
2018
2
Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis. ( 29568342 )
2018
3
Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and I+-defensins. ( 26831845 )
2016
4
The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: A randomised controlled trial. ( 26994623 )
2016
5
Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis. ( 27746841 )
2016
6
Chronic rhinitis in the cat. ( 24268332 )
2014
7
Radiofrequency inferior turbinate reduction improves smell ability of patients with chronic rhinitis and inferior turbinate hypertrophy. ( 24612902 )
2014
8
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. ( 24607046 )
2014
9
Increased proportions of CCR4&amp;lt;sup&amp;gt;+&amp;lt;/sup&amp;gt; cells among peripheral blood CD4&amp;lt;sup&amp;gt;+&amp;lt;/sup&amp;gt; cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis. ( 25650058 )
2014
10
Correlation between skin-prick testing, individual specific IgE tests, and a multiallergen IgE assay for allergy detection in patients with chronic rhinitis. ( 25198024 )
2014
11
Combined radiofrequency volumetric tissue reduction and lateral outfracture of hypertrophic inferior turbinate in the treatment of chronic rhinitis: short-term and long-term outcome. ( 24415652 )
2014
12
Prevalence of chronic rhinitis in Thai patients with obstructive sleep disordered breathing. ( 24163993 )
2013
13
Bronchial asthma control after argon plasma coagulation turbinectomy in patients with chronic rhinitis. ( 24141470 )
2013
14
A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. ( 24654314 )
2013
15
Correlation between skin prick test and MAST-immunoblot results in patients with chronic rhinitis. ( 23517390 )
2013
16
The peculiarities of different types of chronic rhinitis in children and adolescents in Kazakhstan. ( 23785676 )
2013
17
Chronic rhinitis in South Africa: update 2013. ( 23725964 )
2013
18
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. ( 23346908 )
2013
19
A study of the role of different forms of chronic rhinitis in the development of otitis media with effusion in children affected by adenoid hypertrophy. ( 24113158 )
2013
20
Changes in the prevalence of asthma and chronic rhinitis in Valencia, Spain: the ORBA project 1983-2003. ( 24654316 )
2013
21
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study. ( 24275145 )
2013
22
Differences in airway inflammation according to atopic status in patients with chronic rhinitis. ( 23130330 )
2012
23
Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. ( 22920071 )
2012
24
Should we perform objective assessment of nasal obstruction in children with chronic rhinitis? ( 23093004 )
2012
25
Vitamin D and chronic rhinitis. ( 22193052 )
2012
26
Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. ( 22521235 )
2012
27
Chronic rhinitis in HTLV-1 carriers: a histopathologic study. ( 22499368 )
2012
28
Improvement of chronic rhinitis under aspirin. ( 22005504 )
2012
29
Epidemiological analysis of chronic rhinitis in pediatric patients. ( 22186247 )
2011
30
Chronic rhinitis: a manifestation of leprosy. ( 21938685 )
2011
31
Chronic rhinitis due to Streptococcus equi subspecies zooepidemicus in a dog. ( 20675628 )
2010
32
Quality of life in patients with chronic rhinitis after radiofrequency inferior turbinate reduction. ( 20718172 )
2010
33
Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. ( 19720248 )
2009
34
Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis. ( 18805880 )
2009
35
Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis. ( 19220164 )
2009
36
Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis. ( 19772760 )
2009
37
Chronic rhinitis secondary to the intrusion of a tooth into the nasal cavity of a cat. ( 19749211 )
2009
38
Rhinoscleroma in a young adult with chronic rhinitis and dyspnea. ( 18816882 )
2008
39
Prevalence of autoimmune thyroid disease in chronic rhinitis. ( 18800326 )
2008
40
Investigation of olfactory threshold responses in chronic rhinitis subtypes. ( 18219841 )
2007
41
The skin prick test results of 977 patients suffering from chronic rhinitis in Hong Kong. ( 17406040 )
2007
42
A correlation of symptomatology with nasal smear eosinophilia in non-infectious chronic rhinitis preliminary report. ( 18072453 )
2007
43
Chronic rhinitis with nasal polyposis associated with sodium glutamate intolerance. ( 17536215 )
2007
44
Functional inferior turbinosurgery (FITS) for the treatment of resistant chronic rhinitis. ( 16803714 )
2006
45
B-cell nasal lymphoma mimicking hyperplastic chronic rhinitis. ( 16815207 )
2006
46
Chronic rhinitis in cats. ( 16711612 )
2006
47
Evaluation of a novel immunotherapy for treatment of chronic rhinitis in cats. ( 16857403 )
2006
48
Subjective and objective nasal obstruction assessment in children with chronic rhinitis. ( 16154642 )
2006
49
What do patients with chronic rhinitis do with their disease? ( 15853854 )
2005
50
The role of atopy in Maltese patients with chronic rhinitis. ( 15142070 )
2004

Variations for Chronic Rhinitis

Expression for Chronic Rhinitis

Search GEO for disease gene expression data for Chronic Rhinitis.

Pathways for Chronic Rhinitis

Pathways related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 ECE1 EDN1
2 10.15 ECE1 EDN1

GO Terms for Chronic Rhinitis

Cellular components related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 ECE1 EDN1

Biological processes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.43 EPX MPO
2 response to mechanical stimulus GO:0009612 9.4 ASNS MPO
3 sensory perception of pain GO:0019233 9.37 EDN1 TRPV1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 EDN1 TRPV1
5 response to amino acid GO:0043200 9.26 ASNS EDN1
6 regulation of vasoconstriction GO:0019229 9.16 ECE1 EDN1
7 hydrogen peroxide catabolic process GO:0042744 8.96 EPX MPO
8 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.62 ECE1 EDN1

Molecular functions related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 EPX MPO

Sources for Chronic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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