MCID: CHR048
MIFTS: 41

Chronic Rhinitis

Categories: Bone diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Chronic Rhinitis

MalaCards integrated aliases for Chronic Rhinitis:

Name: Chronic Rhinitis 12 55 15 73
Rhinitis - Chronic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8252
ICD10 33 J31.0
ICD9CM 35 472.0
NCIt 50 C34479
SNOMED-CT 68 86094006
UMLS 73 C0008711

Summaries for Chronic Rhinitis

Disease Ontology : 12 A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

MalaCards based summary : Chronic Rhinitis, also known as rhinitis - chronic, is related to asthma and rhinitis, and has symptoms including rhinorrhea, purulent rhinitis and catarrh. An important gene associated with Chronic Rhinitis is EDN1 (Endothelin 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Endothelin Pathways. The drugs Capsaicin and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Chronic Rhinitis

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Chronic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 asthma 29.8 EDN1 EPX MPO TRPV1
2 rhinitis 10.8
3 pharyngitis 10.7
4 nasopharyngitis 10.3
5 sinusitis 10.1
6 idiopathic edema 10.1 EDN1 MPO
7 eosinophil peroxidase deficiency 10.1 EPX MPO
8 collagenous colitis 10.1 EPX MPO
9 orthostatic intolerance 10.1 ECE1 EDN1
10 pollen allergy 10.1 EPX MPO
11 proctitis 10.1 EPX MPO
12 vernal conjunctivitis 10.1 EPX MPO
13 mononeuropathy 10.0 MPO TRPV1
14 arteries, anomalies of 10.0 EDN1 TRPV1
15 bronchial disease 10.0 EPX TRPV1
16 urinary system disease 10.0 EDN1 TRPV1
17 vasomotor rhinitis 9.9
18 maxillary sinusitis 9.9 MPO RHNO1
19 intestinal disease 9.9 MPO TRPV1
20 chronic maxillary sinusitis 9.9 MPO RHNO1
21 ischemia 9.9 EDN1 MPO TRPV1
22 headache 9.9
23 nasal cavity disease 9.9 RHNO1 TRPV1
24 nose disease 9.9 RHNO1 TRPV1
25 upper respiratory tract disease 9.9 RHNO1 TRPV1
26 precursor t-cell acute lymphoblastic leukemia 9.9 ASNS MPO
27 respiratory system disease 9.8 MPO TRPV1
28 leukemia, chronic lymphocytic 2 9.8
29 leukemia, chronic lymphocytic 9.8
30 otitis media 9.8
31 acute insulin response 9.8
32 pulmonary disease, chronic obstructive 9.8
33 allergic rhinitis 9.8
34 leukemia 9.8
35 lymphoma 9.8
36 adenoid hypertrophy 9.8
37 lymphocytic leukemia 9.8
38 rhinoscleroma 9.8
39 laryngitis 9.8
40 bronchitis 9.8
41 hypereosinophilic syndrome 9.8
42 leukemia, b-cell, chronic 9.8
43 fibromyalgia 9.8
44 dermatitis, atopic 9.6
45 urticaria 9.6
46 dermatitis 9.6
47 dacryocystitis 9.6

Comorbidity relations with Chronic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Rhinitis:



Diseases related to Chronic Rhinitis

Symptoms & Phenotypes for Chronic Rhinitis

UMLS symptoms related to Chronic Rhinitis:


rhinorrhea, purulent rhinitis, catarrh

GenomeRNAi Phenotypes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.7 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.7 ASNS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.7 MPO
4 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.7 MPO
5 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.7 EDN1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.7 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.7 MPO
8 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.7 EDN1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.7 ASNS
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.7 ASNS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.7 ASNS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.7 ASNS
13 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.7 ASNS
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.7 EDN1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.7 MPO
16 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.7 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.7 EDN1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.7 MPO
19 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.7 ASNS MPO
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.7 ASNS EDN1 MPO
21 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.7 EDN1

Drugs & Therapeutics for Chronic Rhinitis

Drugs for Chronic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 4 404-86-4 1548943
2
mometasone furoate Approved, Vet_approved Phase 4 83919-23-7
3 Dermatologic Agents Phase 4
4 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
5 Antipruritics Phase 4
6 Anti-Allergic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4,Phase 3
8 Pharmaceutical Solutions Phase 3
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
10 glucocorticoids Phase 3
11 Antibiotics, Antitubercular Phase 3
12
Beclomethasone Phase 3 4419-39-0 20469
13 Hormone Antagonists Phase 3
14 Respiratory System Agents Phase 3,Phase 2,Not Applicable
15 Anti-Asthmatic Agents Phase 3
16 Hormones Phase 3
17 Anti-Bacterial Agents Phase 3
18
Ephedrine Approved Phase 2,Not Applicable 299-42-3 9294
19
Pseudoephedrine Approved Phase 2,Not Applicable 90-82-4 7028
20
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
21 Ginkgo Phase 2
22 Autonomic Agents Phase 2,Not Applicable
23 Neurotransmitter Agents Phase 2,Not Applicable
24 Sympathomimetics Phase 2,Not Applicable
25 Vasoconstrictor Agents Phase 2,Not Applicable
26 Appetite Depressants Phase 2
27 Adrenergic Agonists Phase 2,Not Applicable
28 Expectorants Phase 2
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
30 Nasal Decongestants Phase 2,Not Applicable
31 Adrenergic alpha-Agonists Phase 2,Not Applicable
32 Adrenergic Agents Phase 2,Not Applicable
33
Chlorpheniramine Phase 2 113-92-8, 132-22-9 2725
34 Anti-Obesity Agents Phase 2
35
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
36
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
37
Racepinephrine Approved Not Applicable 329-65-7 838
38
Nitric Oxide Approved 10102-43-9 145068
39
Oxymetazoline Approved, Investigational Not Applicable 1491-59-4 4636
40
Phenylephrine Approved Not Applicable 59-42-7 6041
41
Pomegranate Experimental, Investigational
42 Epinephryl borate Not Applicable
43 Anesthetics Not Applicable
44 Protective Agents ,Not Applicable
45 Endothelium-Dependent Relaxing Factors
46 Free Radical Scavengers
47 Antioxidants
48 Bronchodilator Agents
49 Vasodilator Agents
50 Mydriatics Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
2 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
3 Study of Asthma and Nasal Steroids Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
4 Surgical Reduction of the Inferior Turbinates for Nasal Obstruction Terminated NCT00737906 Phase 4
5 Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
6 Impact of Acupuncture on Vasomotor Rhinitis Completed NCT00682162 Phase 3
7 beCLomethasone Efficacy in Acute Rhinosinusitis - CLEAR Study Completed NCT01691677 Phase 3 beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days;placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days
8 Role of Ginkgo Biloba Extract in IUGR Completed NCT02425436 Phase 2 Ginkgo Biloba Extract
9 The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Recruiting NCT01364467 Phase 2 Placebo;Guaifenesin
10 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Unknown status NCT02000648
11 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic Rhinosinusitis Unknown status NCT01564849
12 A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Rhinorrhea. Unknown status NCT01546662 Not Applicable
13 A Randomized Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction Completed NCT01054521 Not Applicable
14 ClariFix Cryoablation Clinical Study Completed NCT02820597 Not Applicable
15 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866
16 Protocol TARC-ABPA Completed NCT01710930 Not Applicable
17 Multi-Treatment PNN Modulation for Chronic Rhinitis Recruiting NCT03791489 Not Applicable
18 Posterior Nasal Nerve (PNN) Rhinitis Study Recruiting NCT03727347 Not Applicable
19 Evaluation of the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis Active, not recruiting NCT03181594 Not Applicable
20 Registry of Subject Treated With ClariFix Enrolling by invitation NCT03739216
21 Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion Terminated NCT00584662 Not Applicable Oxymetazoline Hydrochloride

Search NIH Clinical Center for Chronic Rhinitis

Genetic Tests for Chronic Rhinitis

Anatomical Context for Chronic Rhinitis

MalaCards organs/tissues related to Chronic Rhinitis:

41
Bone, Testes, Lung, Skin, Thyroid, B Cells, T Cells

Publications for Chronic Rhinitis

Articles related to Chronic Rhinitis:

(show top 50) (show all 139)
# Title Authors Year
1
Gene and protein expression of <i>CXCR4</i> in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations. ( 29497453 )
2018
2
Smoking, environmental tobacco smoke and occupational irritants increase the risk of chronic rhinitis. ( 29568342 )
2018
3
Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis. ( 30253652 )
2018
4
Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants. ( 30285942 )
2018
5
Chronic Rhinitis Is a High-Risk Comorbidity for 30-Day Hospital Readmission of Patients with Asthma and Chronic Obstructive Pulmonary Disease. ( 30053594 )
2018
6
Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta-analysis. ( 30054985 )
2018
7
Therapeutic effect of chlorpheniramine in treatingupper airway cough syndrome (UACS) and chronic rhinitis/sinusitis. ( 30203761 )
2018
8
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. ( 30229670 )
2018
9
Endotypes of chronic rhinitis: A cluster analysis study. ( 30353934 )
2018
10
Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis. ( 30506053 )
2018
11
Biomarker assessment in chronic rhinitis and chronic rhinosinusitis: Endothelin-1, TARC/CCL17, neopterin, and I+-defensins. ( 26831845 )
2016
12
The effectiveness of oxymetazoline plus intranasal steroid in the treatment of chronic rhinitis: A randomised controlled trial. ( 26994623 )
2016
13
Diagnostic Utility of Urinary LTE4 in Asthma, Allergic Rhinitis, Chronic Rhinosinusitis, Nasal Polyps, and Aspirin Sensitivity. ( 27080204 )
2016
14
Granulocyte-Macrophage Colony-Stimulating Factor Production and Tissue Eosinophilia in Chronic Rhinitis. ( 27746841 )
2016
15
Chronic rhinitis in the cat. ( 24268332 )
2014
16
Radiofrequency inferior turbinate reduction improves smell ability of patients with chronic rhinitis and inferior turbinate hypertrophy. ( 24612902 )
2014
17
Long-term, randomized safety study of MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) in subjects with chronic rhinitis. ( 24607046 )
2014
18
Increased proportions of CCR4&amp;lt;sup&amp;gt;+&amp;lt;/sup&amp;gt; cells among peripheral blood CD4&amp;lt;sup&amp;gt;+&amp;lt;/sup&amp;gt; cells and serum levels of allergen-specific IgE antibody in canine chronic rhinitis and bronchitis. ( 25650058 )
2014
19
Correlation between skin-prick testing, individual specific IgE tests, and a multiallergen IgE assay for allergy detection in patients with chronic rhinitis. ( 25198024 )
2014
20
Combined radiofrequency volumetric tissue reduction and lateral outfracture of hypertrophic inferior turbinate in the treatment of chronic rhinitis: short-term and long-term outcome. ( 24415652 )
2014
21
Allergic rhinitis, chronic rhinosinusitis and nasal polyposis in Asia Pacific: impact on quality of life and sleep. ( 25097847 )
2014
22
Prevalence of chronic rhinitis in Thai patients with obstructive sleep disordered breathing. ( 24163993 )
2013
23
Bronchial asthma control after argon plasma coagulation turbinectomy in patients with chronic rhinitis. ( 24141470 )
2013
24
A new therapy (MP29-02) is effective for the long-term treatment of chronic rhinitis. ( 24654314 )
2013
25
Correlation between skin prick test and MAST-immunoblot results in patients with chronic rhinitis. ( 23517390 )
2013
26
The peculiarities of different types of chronic rhinitis in children and adolescents in Kazakhstan. ( 23785676 )
2013
27
Chronic rhinitis in South Africa: update 2013. ( 23725964 )
2013
28
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men. ( 23346908 )
2013
29
A study of the role of different forms of chronic rhinitis in the development of otitis media with effusion in children affected by adenoid hypertrophy. ( 24113158 )
2013
30
Changes in the prevalence of asthma and chronic rhinitis in Valencia, Spain: the ORBA project 1983-2003. ( 24654316 )
2013
31
Chronic rhinitis and its association with headache frequency and disability in persons with migraine: Results of the American Migraine Prevalence and Prevention (AMPP) Study. ( 24275145 )
2013
32
Differences in airway inflammation according to atopic status in patients with chronic rhinitis. ( 23130330 )
2012
33
Clinical characteristics of chronic rhinitis patients with high vs low irritant trigger burdens. ( 22920071 )
2012
34
Should we perform objective assessment of nasal obstruction in children with chronic rhinitis? ( 23093004 )
2012
35
Vitamin D and chronic rhinitis. ( 22193052 )
2012
36
Smoking and chronic rhinitis: effects of nasal irrigations with sulfurous-arsenical-ferruginous thermal water: A prospective, randomized, double-blind study. ( 22521235 )
2012
37
Chronic rhinitis in HTLV-1 carriers: a histopathologic study. ( 22499368 )
2012
38
Improvement of chronic rhinitis under aspirin. ( 22005504 )
2012
39
Allergic rhinitis, chronic rhinosinusitis, and symptom severity: a population-based study. ( 22311842 )
2012
40
Epidemiological analysis of chronic rhinitis in pediatric patients. ( 22186247 )
2011
41
Chronic rhinitis: a manifestation of leprosy. ( 21938685 )
2011
42
Chronic rhinitis due to Streptococcus equi subspecies zooepidemicus in a dog. ( 20675628 )
2010
43
Quality of life in patients with chronic rhinitis after radiofrequency inferior turbinate reduction. ( 20718172 )
2010
44
Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study. ( 19720248 )
2009
45
Performance of self-reported occupational exposure compared to a job-exposure matrix approach in asthma and chronic rhinitis. ( 18805880 )
2009
46
Pharmacokinetic characteristics and safety and tolerability of a reformulated azelastine hydrochloride nasal spray in patients with chronic rhinitis. ( 19220164 )
2009
47
Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis. ( 19772760 )
2009
48
Chronic rhinitis secondary to the intrusion of a tooth into the nasal cavity of a cat. ( 19749211 )
2009
49
Rhinoscleroma in a young adult with chronic rhinitis and dyspnea. ( 18816882 )
2008
50
Prevalence of autoimmune thyroid disease in chronic rhinitis. ( 18800326 )
2008

Variations for Chronic Rhinitis

Expression for Chronic Rhinitis

Search GEO for disease gene expression data for Chronic Rhinitis.

Pathways for Chronic Rhinitis

Pathways related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 ECE1 EDN1
2 10.15 ECE1 EDN1

GO Terms for Chronic Rhinitis

Cellular components related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 ECE1 EDN1

Biological processes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.43 EPX MPO
2 response to mechanical stimulus GO:0009612 9.4 ASNS MPO
3 sensory perception of pain GO:0019233 9.37 EDN1 TRPV1
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.32 EDN1 TRPV1
5 response to amino acid GO:0043200 9.26 ASNS EDN1
6 hydrogen peroxide catabolic process GO:0042744 9.16 EPX MPO
7 regulation of vasoconstriction GO:0019229 8.96 ECE1 EDN1
8 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.62 ECE1 EDN1

Molecular functions related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 EPX MPO

Sources for Chronic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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