MCID: CHR048
MIFTS: 42

Chronic Rhinitis

Categories: Bone diseases, Respiratory diseases, Smell/Taste diseases

Aliases & Classifications for Chronic Rhinitis

MalaCards integrated aliases for Chronic Rhinitis:

Name: Chronic Rhinitis 12 55 15 72 33
Rhinitis - Chronic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8252
ICD9CM 35 472.0
NCIt 50 C34479
SNOMED-CT 68 86094006
ICD10 33 J31.0
UMLS 72 C0008711

Summaries for Chronic Rhinitis

Disease Ontology : 12 A rhinitis which is persistent and long-lasting. It may occur with diseases such as syphilis, tuberculosis, rhinoscleroma, rhinosporidiosis, leishmaniasis, blastomycosis, histoplasmosis, and leprosy, all of which are characterized by the formation of inflamed lesions (granulomas) and the destruction of soft tissue, cartilage, and bone. Chronic rhinitis causes nasal obstruction, pus-filled discharge from the nose, and frequent bleeding.

MalaCards based summary : Chronic Rhinitis, also known as rhinitis - chronic, is related to allergic rhinitis and maxillary sinusitis, and has symptoms including rhinorrhea, purulent rhinitis and catarrh. An important gene associated with Chronic Rhinitis is EDN1 (Endothelin 1), and among its related pathways/superpathways are Melatonin metabolism and effects and Endothelin Pathways. The drugs Histamine and Azelastine have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and skin.

Related Diseases for Chronic Rhinitis

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Chronic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 allergic rhinitis 30.1 MS4A2 MPO EPX
2 maxillary sinusitis 29.9 RHNO1 MPO
3 conjunctivitis 29.5 MS4A2 EPX
4 allergic asthma 29.0 MS4A2 EPX
5 allergic hypersensitivity disease 28.6 MS4A2 EPX
6 asthma 28.4 MS4A2 MPO EPX EDN1
7 rhinitis 11.0
8 pharyngitis 10.9
9 nasopharyngitis 10.4
10 vasomotor rhinitis 10.3
11 ige responsiveness, atopic 10.3
12 idiopathic edema 10.3 MPO EDN1
13 hypereosinophilic syndrome 10.2
14 eosinophil peroxidase deficiency 10.2 MPO EPX
15 orthostatic intolerance 10.2 EDN1 ECE1
16 collagenous colitis 10.2 MPO EPX
17 proctitis 10.2 MPO EPX
18 chronic maxillary sinusitis 10.1 RHNO1 MPO
19 atrophic rhinitis 10.0
20 bronchitis 10.0
21 proteasome-associated autoinflammatory syndrome 1 9.9
22 adenoid hypertrophy 9.9
23 headache 9.9
24 cleft palate, isolated 9.8
25 leukemia, chronic lymphocytic 9.8
26 migraine with or without aura 1 9.8
27 otitis media 9.8
28 tobacco addiction 9.8
29 leprosy 3 9.8
30 pulmonary disease, chronic obstructive 9.8
31 lymphoma 9.8
32 pollen allergy 9.8
33 lymphocytic leukemia 9.8
34 common cold 9.8
35 rhinoscleroma 9.8
36 leukemia 9.8
37 glossitis 9.8
38 dermatitis 9.8
39 laryngitis 9.8
40 fibromyalgia 9.8
41 influenza 9.8
42 lung disease 9.8
43 stomatitis 9.8
44 47,xyy 9.8
45 hansen's disease 9.8
46 leukemia, b-cell, chronic 9.8
47 lymphosarcoma 9.8
48 juvenile nasopharyngeal angiofibroma 9.8
49 food allergy 9.7 MS4A2 EPX
50 conjunctival disease 9.7 RHNO1 MS4A2

Comorbidity relations with Chronic Rhinitis via Phenotypic Disease Network (PDN):


Anxiety Bronchitis
Esophagitis Heart Disease
Hypertension, Essential

Graphical network of the top 20 diseases related to Chronic Rhinitis:



Diseases related to Chronic Rhinitis

Symptoms & Phenotypes for Chronic Rhinitis

UMLS symptoms related to Chronic Rhinitis:


rhinorrhea, purulent rhinitis, catarrh

Drugs & Therapeutics for Chronic Rhinitis

Drugs for Chronic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Azelastine Approved Phase 4 58581-89-8 2267
3
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
4 Anti-Inflammatory Agents Phase 4
5
Histamine Phosphate Phase 4 51-74-1 65513
6 Histamine Antagonists Phase 4
7 Histamine H1 Antagonists Phase 4
8 Anti-Asthmatic Agents Phase 4
9 Histamine H1 Antagonists, Non-Sedating Phase 4
10 Bronchodilator Agents Phase 4
11 Analgesics Phase 4
12 Anti-Allergic Agents Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Olopatadine Hydrochloride Phase 4
15 Lipoxygenase Inhibitors Phase 4
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4
17 Antirheumatic Agents Phase 4
18
Licorice Approved Phase 2, Phase 3
19 glucocorticoids Phase 3
20 Hormones Phase 3
21 Hormone Antagonists Phase 3
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
23 Anti-Bacterial Agents Phase 3
24 Anti-Infective Agents Phase 3
25 Antibiotics, Antitubercular Phase 3
26
Beclomethasone Phase 3 4419-39-0 20469
27 Pharmaceutical Solutions Phase 2, Phase 3
28
Theophylline Approved Phase 2 58-55-9 2153
29
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
30
Chlorpheniramine Approved Phase 2 132-22-9, 113-92-8 2725
31 Neurotransmitter Agents Phase 2
32 Respiratory System Agents Phase 2
33 Peripheral Nervous System Agents Phase 2
34 Autonomic Agents Phase 2
35 Vasodilator Agents Phase 2
36 Ginkgo Phase 2
37 Purinergic P1 Receptor Antagonists Phase 2
38 Phosphodiesterase Inhibitors Phase 2
39 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
40 Anti-Obesity Agents Phase 2
41 Expectorants Phase 2
42 Appetite Depressants Phase 2
43
Capsaicin Approved Phase 1 404-86-4 1548943
44 Dermatologic Agents Phase 1
45 Antipruritics Phase 1
46
Lidocaine Approved, Vet_approved 137-58-6 3676
47
Epinephrine Approved, Vet_approved 51-43-4 5816
48
Racepinephrine Approved 329-65-7 838
49
Ethanol Approved 64-17-5 702
50
Benzyl alcohol Approved 100-51-6 244

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Unknown status NCT02288156 Phase 4 Capsaicin;placebo
2 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
3 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
4 Study of Asthma and Nasal Steroids for the American Lung Association-Airways Clinical Research Centers Completed NCT01118312 Phase 4 Mometasone Furoate monohydrate
5 Surgical Reduction of the Inferior Turbinate Using a Coblation® Device for Treatment of Nasal Obstruction: A Prospective, Multi-center Clinical Study Terminated NCT00737906 Phase 4
6 Phase III Randomized Open-label Clinical Trial Comparing Cleanoze® Irrigation Device With Powder Preparation Versus Conventional Irrigation Method for Chronic Rhinitis Completed NCT02763241 Phase 3 Cleanoze®;Saline (Syringe irrigation)
7 Multicentre, Randomized, Double-blind, Parallel Group, Placebo-Controlled Study on the Therapeutic Efficacy and Safety of Beclomethasone Dipropionate Suspension for Inhalation 800 µg Twice Daily vs. Placebo Added to Antibiotic Therapy in Patients With Acute Rhinosinusitis Completed NCT01691677 Phase 3 beclomethasone dipropionate 800 mcg/2 ml suspension for nebulization,one administration b.i.d. for 14 days;placebo 2 ml suspension for nebulization, one administration b.i.d. for 14 days
8 Impact of Acupuncture on Vasomotor Rhinitis: a Randomised Placebo Controlled Pilot Study Completed NCT00682162 Phase 3
9 Chia Yi Chang Gung Memorial Hospital Not yet recruiting NCT04046393 Phase 2, Phase 3
10 Effects of Oral Ginkgo Biloba Extract on Pregnancy Complicated by Asymmetrically Intrauterine Growth Restriction: a Double-blinded Randomized Placebo-controlled Trial Completed NCT02425436 Phase 2 Ginkgo Biloba Extract
11 The Effect of Theophylline in Patients With Allergic Rhinitis Completed NCT01132781 Phase 2 Theophylline (Intervention Group);Placebo (Placebo Group)
12 The Effect of Oral Guaifenesin on Pediatric Chronic Rhinitis: A Pilot Study Recruiting NCT01364467 Phase 2 Placebo;Guaifenesin
13 Tolerability of Intranasal Capsaicinoid Spray Recruiting NCT03952845 Phase 1
14 The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract (PFE) for Patients With Chronic Rhinitis, Chronic Sinusitis With or Without Nasal Polyps Unknown status NCT01564849
15 The Correlation Between Adenoid Hypertrophy and Body Temperature in Children Before and After Adenoidectomy Unknown status NCT02965183
16 Nasal Findings in Reactive Airway Diseases Unknown status NCT03131323
17 A Randomized Double Dummy Double Blind Dose Determining Place-bo Controlled Study to Evaluate Efficacy of Investigational Product E-RH-06 at 2 Dose Levels for the Metabolic Management of Chronic or Recurrent, Non-infective Nasal Congestion With-or-without Rhinorrhea. Unknown status NCT01546662
18 Real-life Management and Therapeutic Outcome of Patients With Chronic Rhinitis and Chronic Urticaria in Thailand Completed NCT02000648
19 Clinical Evaluation of Cryotherapy in the Nasal Passageway Using the ClariFix Device Completed NCT02820597
20 XprESS Device and PathAssist Confirmation Tools in Pediatric Patients-Expanded Indication Study Completed NCT02278484
21 A Randomized Comparison Study of Temperature-controlled and Bipolar Radiofrequency for Inferior Turbinate Reduction in Patients With Chronic Rhinitis Completed NCT01054521
22 Are Technicians Showing Bronchial Hyperreactivity Able to Safely Perform Bronchial Provocation Tests? Completed NCT01937494 histamine-benzylic alcohol (magistral preparation)
23 Evaluation Effects of Nasal Nitric Oxide Measurements Are Associated With Atopy Status in Chronic Nasal Inflammation Completed NCT01295866
24 Seinäjoki Adult Asthma Study: A 12-year Real-life Follow-up Study of New-onset Asthma Diagnosed at Adult Age and Treated in Primary and Specialized Care. Finnish Title: Diagnoosista Hoitotasapainoon: Voidaanko Aikuisen Astman Hoitotasapainoa Ennustaa Diagnoosivaiheen löydösten ja Astman Ilmiasun Perusteella? Completed NCT02733016
25 Impact of Age on the Prevalence of Allergic Sensitization Completed NCT02730520
26 Phenotyping the Chronic Respiratory Diseases (CRD) in Ho Chi Minh City, Vietnam Completed NCT02517983
27 Study of Medication for Nonallergic Rhinitis (NAR) Based on Cluster Analysis Recruiting NCT04002349 Budesonide Nasal Spray (Rhinocort, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.);Levocabastine Nasal Spray (Livostine, Shanghai Johnson & Johnson Pharmaceuticals, Ltd.);0.9% natural saline
28 Feasibility Study of Multi-Treatment Posterior Nasal Nerve Modulation for Treatment of Chronic Rhinitis Active, not recruiting NCT03791489
29 Clinical Evaluation of Safety and Efficacy for the ClariFix™ Cryotherapy Device in Subjects With Chronic Rhinitis Active, not recruiting NCT03181594
30 Clinical Evaluation of Low Power Radiofrequency Energy Applied to the Posterior Nasal Nerve Area for Symptomatic Relief of Chronic Rhinitis Active, not recruiting NCT03727347
31 A Prospective, Multi-Center Registry of Subjects Treated With the ClariFix Cryotherapy Device Active, not recruiting NCT03739216
32 Oxymetazoline Hydrochloride in Combination With Nasal Glucocorticosteroid for Perennial Allergic and Non-allergic Rhinitis in Subjects With Persistent Nasal Congestion Terminated NCT00584662 Oxymetazoline Hydrochloride
33 Olfactory Training for Olfactory Dysfunction in Chronic Rhinosinusitis Withdrawn NCT03055572

Search NIH Clinical Center for Chronic Rhinitis

Genetic Tests for Chronic Rhinitis

Anatomical Context for Chronic Rhinitis

MalaCards organs/tissues related to Chronic Rhinitis:

41
Testes, Bone, Skin, Lung, T Cells, Breast, Thyroid

Publications for Chronic Rhinitis

Articles related to Chronic Rhinitis:

(show top 50) (show all 828)
# Title Authors PMID Year
1
Further improvement of quality of life by cetirizine in perennial allergic rhinitis as a function of treatment duration. 9 38
10879992 2000
2
Allergic rhinitis in children: effects of flunisolide and disodium cromoglycate on nasal eosinophil cationic protein. 9 38
9088653 1997
3
Life-long endogenous estrogen exposure is associated with prevalence of allergic rhinitis in postmenopausal women. 38
30889092 2019
4
Specific immunoglobulin E in nasal secretions for the diagnosis of local allergic rhinitis. 38
31129685 2019
5
[The role and research progress of exosomes in chronic inflammatory diseases of airway]. 38
31327215 2019
6
How to Diagnose and Treat Local Allergic Rhinitis: A Challenge for Clinicians. 38
31331047 2019
7
Group 2 Innate Lymphoid Cells in Airway Diseases. 38
31082387 2019
8
[The significance of eosinophils in the correlation of upper and lower airway inflammation in patients with chronic rhinitis]. 38
31262111 2019
9
The prevalence and characteristics of local allergic rhinitis in Poland. 38
30556065 2019
10
The role of nasal cytology in the diagnosis of allergic and non-allergic rhinitis in adult and children. 38
31298361 2019
11
Bilateral pararhinotomy with middle meatal antrostomy of the maxillary sinus in a rabbit (Oryctolagus cuniculus) with chronic rhinitis. 38
31067176 2019
12
Diagnosis and Treatment of a Swainson's Toucan (Ramphastos ambiguus swainsonii) With Rhinosinusitis. 38
31251503 2019
13
Mucoid Pseudomonas aeruginosa infection in a cat with severe chronic rhinosinusitis. 38
31210366 2019
14
Blood eosinophils may predict radiographic sinus opacification in patients with chronic rhinitis. 38
30576087 2019
15
Nasal Cytology as a Diagnostic Tool for Local Allergic Rhinitis. 38
31115246 2019
16
Association between Sleep Duration and Chronic Rhinosinusitis among the Korean General Adult Population: Korea National Health and Nutrition Examination Survey. 38
31073196 2019
17
Endotypes of chronic rhinitis: A cluster analysis study. 38
30353934 2019
18
[Nasal discharge in dogs - are microbiological and histopathological examinations clinically useful?] 38
31013526 2019
19
[Exogenous lipoid pneumonia induced by long-term usage of compound menthol nasal drops: a case report]. 38
30996383 2019
20
Home environment and diseases in early life are associated with allergic rhinitis. 38
30578996 2019
21
Prevalence of local allergic rhinitis to Dermatophagoides pteronyssinus in chronic rhinitis with negative skin prick test. 38
30903999 2019
22
Postoperative infection following strabismus surgery: case series and increased incidence in a single referral center. 38
30611002 2019
23
Differentiating Rhinitis in the Paediatric Population by Giving Focus on Medical History and Clinical Examination. 38
30813653 2019
24
Predictive and Diagnostic Value of Fractional Exhaled Nitric Oxide in Patients with Chronic Rhinosinusitis. 38
30612135 2019
25
Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases. 38
30705747 2019
26
Relationship between upper airway diseases, exhaled nitric oxide, and bronchial hyperresponsiveness to methacholine. 38
29432042 2019
27
Long Noncoding RNAs and Messenger RNAs Expression Profiles Potentially Regulated by ZBTB7A in Nasopharyngeal Carcinoma. 38
31309112 2019
28
Chronic Rhinitis Is a High-Risk Comorbidity for 30-Day Hospital Readmission of Patients with Asthma and Chronic Obstructive Pulmonary Disease. 38
30053594 2019
29
Minimal clinically important difference for the rhinoconjunctivitis quality of life questionnaire in allergic rhinitis in Thai population. 38
30740354 2019
30
Novel therapeutic targets for allergic airway disease in children. 38
31391855 2019
31
[Application of nasal saline irrigation in nasal inflammatory diseases]. 38
30669208 2019
32
Urine Bacteria-Derived Extracellular Vesicles and Allergic Airway Diseases in Children. 38
30415264 2019
33
Current opinions for the management of asthma associated with ear, nose and throat comorbidities. 38
30463872 2018
34
Recent developments and highlights in biomarkers in allergic diseases and asthma. 38
30289997 2018
35
Effects of decongestant addition to intranasal corticosteroid for chronic rhinitis: a systematic review and meta-analysis. 38
30054985 2018
36
Cryotherapy for the Treatment of Chronic Rhinitis: A Qualitative Systematic Review. 38
30229670 2018
37
Role of Superantigens in Allergic Inflammation: Their Relationship to Allergic Rhinitis, Chronic Rhinosinusitis, Asthma, and Atopic Dermatitis. 38
30253652 2018
38
The effect of omalizumab treatment on severe allergic asthma and allergic comorbidities: real-life experience from the Czech Anti-IgE Registry. 38
30429711 2018
39
Never too old for an inherited condition. 38
30288904 2018
40
A proposed scheme to cope with comorbidities in asthma. 38
30149069 2018
41
Breakthrough cancer pain tailored treatment: which factors influence the medication choice? An observational, prospective and cross-sectional study in patients with terminal cancer. 38
30317182 2018
42
IgG4-related orbital disease. 38
29866378 2018
43
Lidocaine/Phenylephrine Nasal Spray versus Nebulization Prior to Nasoendoscopy: A Randomized Controlled Trial. 38
30126325 2018
44
The effect of urban particulate matter on cultured human nasal fibroblasts. 38
29979839 2018
45
Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis. 38
30506053 2018
46
miR‑495 enhances the efficacy of radiotherapy by targeting GRP78 to regulate EMT in nasopharyngeal carcinoma cells. 38
30015969 2018
47
Clara cell protein 16 release from the nasal mucosa in allergic rhinitis, chronic rhinosinusitis, and exposure to air pollutants. 38
30285942 2018
48
Comorbid "treatable traits" in difficult asthma: Current evidence and clinical evaluation. 38
29178130 2018
49
Managing comorbid conditions in severe asthma. 38
30453867 2018
50
Granulomatous rhinitis secondary to feline leishmaniosis: report of an unusual presentation and therapeutic complications. 38
30450219 2018

Variations for Chronic Rhinitis

Expression for Chronic Rhinitis

Search GEO for disease gene expression data for Chronic Rhinitis.

Pathways for Chronic Rhinitis

Pathways related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 EDN1 ECE1
2 10.15 EDN1 ECE1

GO Terms for Chronic Rhinitis

Cellular components related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Weibel-Palade body GO:0033093 8.62 EDN1 ECE1

Biological processes related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.37 MPO EPX
2 response to mechanical stimulus GO:0009612 9.32 MPO ASNS
3 response to amino acid GO:0043200 9.26 EDN1 ASNS
4 hydrogen peroxide catabolic process GO:0042744 9.16 MPO EPX
5 regulation of vasoconstriction GO:0019229 8.96 EDN1 ECE1
6 regulation of systemic arterial blood pressure by endothelin GO:0003100 8.62 EDN1 ECE1

Molecular functions related to Chronic Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxidase activity GO:0004601 8.62 MPO EPX

Sources for Chronic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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