Chronic Salpingitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR099 MIFTS: 35	Chronic Salpingitis Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Chronic Salpingitis

MalaCards integrated aliases for Chronic Salpingitis:

Name: Chronic Salpingitis ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5731

ICD10 ³³ N70.11

NCIt ⁵⁰ C40118

SNOMED-CT ⁶⁸ 55551005

UMLS ⁷³ C0269041

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Summaries for Chronic Salpingitis

MalaCards based summary : Chronic Salpingitis is related to salpingitis isthmica nodosa and salpingitis. An important gene associated with Chronic Salpingitis is OVGP1 (Oviductal Glycoprotein 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Modulation and Signaling. Affiliated tissues include lung, skin and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Chronic Salpingitis

Diseases in the Salpingitis family:

Acute Salpingitis

Chronic Salpingitis

Diseases related to Chronic Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)

#	Related Disease	Score	Top Affiliating Genes
1	salpingitis isthmica nodosa	32.1	AVPR2 HSPA4 KANTR
2	salpingitis	31.1	OVGP1 TNF
3	chronic gonococcal salpingitis	30.8	BAK1 BLK CLEC2A CTSA HRK MCL1
4	chronic salpingo-oophoritis	11.7
5	acute gonococcal salpingitis	10.3	CTSA TNF
6	retinitis pigmentosa 75	10.2	TNF TNFRSF1A
7	skin sarcoidosis	10.2	TNF TNFRSF1B
8	juvenile ankylosing spondylitis	10.2	TNF TNFRSF1B
9	granulomatous dermatitis	10.2	TNF TNFRSF1B
10	scleral disease	10.2	TNF TNFRSF1B
11	pericoronitis	10.2	TNFRSF1A TNFRSF1B
12	pustulosis of palm and sole	10.2	TNF TNFRSF1B
13	rheumatoid lung disease	10.2	TNF TNFRSF1B
14	necrobiosis lipoidica	10.2	SLC2A1 TNFRSF1B
15	peroneal neuropathy	10.2	TNF TNFRSF1B
16	atrophy of prostate	10.2	SLC2A1 TP53
17	periodic fever, familial, autosomal dominant	10.2	TNF TNFRSF1A TNFRSF1B
18	post-transplant lymphoproliferative disease	10.2	TNF TNFRSF1A TNFRSF1B
19	palindromic rheumatism	10.1	TNF TNFRSF1A TNFRSF1B
20	guillain-barre syndrome	10.1	TNF TNFRSF1A TNFRSF1B
21	thyroid lymphoma	10.1	TNF TP53
22	chlamydia	10.1
23	relapsing fever	10.1	TNF TNFRSF1A
24	trench fever	10.1	KANTR TNF
25	psoriatic arthritis	10.1	TNF TNFRSF1A TNFRSF1B
26	leukocyte disease	10.1	MCL1 TNF TP53
27	glomangiosarcoma	10.1	KANTR TP53
28	testicular trophoblastic tumor	10.0	CSH1 CSH2
29	cogan syndrome	10.0	HSPA4 TNF TNFRSF1B
30	choriocarcinoma of ovary	10.0	CSH1 CSH2
31	sciatic neuropathy	10.0	KANTR TNFRSF1A TNFRSF1B
32	cochlear disease	10.0	KANTR TNFRSF1B
33	dystrophinopathies	10.0	TNF TNFRSF1A
34	large intestine cancer	10.0	LARS SLC2A1 TNF TP53
35	acute vascular insufficiency of intestine	10.0	HSPA4 TNF
36	non-gestational choriocarcinoma	9.9	CSH1 CSH2
37	choriocarcinoma of the testis	9.9	CSH1 CSH2
38	lymphoma, non-hodgkin, familial	9.9	BAK1 MCL1 TNFRSF1A TP53
39	germ cell and embryonal cancer	9.9	CSH1 CSH2 TP53
40	uterine anomalies	9.9	CSH1 CSH2 TP53
41	endometriosis	9.9
42	adenomatoid tumor	9.9
43	nervous system disease	9.9	KANTR TNF TP53
44	female reproductive system disease	9.8	CSH1 CSH2 TNF TP53
45	acute salpingitis	9.3	BAK1 BLK CLEC2A CTSA HRK MCL1

Graphical network of the top 20 diseases related to Chronic Salpingitis:

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Symptoms & Phenotypes for Chronic Salpingitis

GenomeRNAi Phenotypes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.74	HRK MCL1 TNF TNFRSF1A TNFRSF1B TP53
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.74	HRK MCL1 TNF TNFRSF1A TNFRSF1B TP53

MGI Mouse Phenotypes related to Chronic Salpingitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	9.56	BAK1 BLK HSPA4 MCL1 TNF TNFRSF1A
2	reproductive system	MP:0005389	9.28	BAK1 BLK CTSA HSPA4 MCL1 OVGP1

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Drugs & Therapeutics for Chronic Salpingitis

Search Clinical Trials , NIH Clinical Center for Chronic Salpingitis

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Genetic Tests for Chronic Salpingitis

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Anatomical Context for Chronic Salpingitis

MalaCards organs/tissues related to Chronic Salpingitis:

⁴¹

Lung, Skin, Ovary, Spinal Cord, Prostate, Thyroid, Testis

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Publications for Chronic Salpingitis

Articles related to Chronic Salpingitis:

(show all 16)

#	Title	Authors	Year
1	Tracing GFP-labeled WJMSCs in vivo using a chronic salpingitis model: an animal experiment. ( 29191249 )	Li Z....Xiao X.M.	2017
2	Treatment evaluation of Wharton's jelly-derived mesenchymal stem cells using a chronic salpingitis model: an animal experiment. ( 29041961 )		2017
3	An incidental finding of chronic salpingitis complications: Tubo-uterine fistula. ( 28976128 )		2017
4	Isolated Tubal Torsion in Patient With Chronic Salpingitis: A Challenging Diagnosis. ( 27678759 )	Pecorini F....Benedetti Panici P.	2015
5	Therapeutic influence of intraperitoneal injection of Wharton's jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis. ( 25966129 )		2015
6	&quot;Tubal ostium sunshine&quot;: hysteroscopic sign of chronic salpingitis. ( 23084667 )		2012
7	Detection of Chlamydia trachomatis DNA in archival paraffinized specimens from chronic salpingitis cases using the polymerase chain reaction. ( 10899513 )		2000
8	Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion. ( 9797114 )		1998
9	Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. ( 8815069 )		1996
10	Postsalpingostomy intercornual bridging with hematosalpinx, chronic salpingitis and perisalpingeal endometriosis. A case report. ( 1564706 )	HonorAc L.H....Scott J.Z.	1992
11	Chronic salpingitis. ( 5905411 )	Pinkerton J.H.	1966
12	Adenomatoid tumor of the fallopian tube associated with chronic salpingitis. ( 14771022 )	LEACH W.B.	1950
13	Chronic salpingitis. ( 20284795 )	SHAW H.N....Gaspar J.	1947
14	Treatment of chronic salpingitis with benzyl cinnamate ester (Jacobson's solution). ( 20252991 )		1947
15	The Treatment of Acute and Chronic Salpingitis. ( 20322471 )	Nash A.B.	1942
16	Chronic Salpingitis: Hysterosalpingectomy in Its Operative Treatment. ( 18745558 )		1940

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Genes for Chronic Salpingitis

Genes related to Chronic Salpingitis (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OVGP1	Oviductal Glycoprotein 1	Protein Coding	16.58	DISEASES inferred ¹⁵
2	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	14.99	DISEASES inferred ¹⁵
3	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	14.45	DISEASES inferred ¹⁵
4	CTSA	Cathepsin A	Protein Coding	14.39	DISEASES inferred ¹⁵
5	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	14.26	DISEASES inferred ¹⁵
6	LARS	Leucyl-TRNA Synthetase	Protein Coding	14.24	DISEASES inferred ¹⁵
7	TNF	Tumor Necrosis Factor	Protein Coding	13.98	DISEASES inferred ¹⁵
8	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	13.95	DISEASES inferred ¹⁵
9	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	13.89	DISEASES inferred ¹⁵
10	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	13.34	DISEASES inferred ¹⁵
11	MCL1	MCL1, BCL2 Family Apoptosis Regulator	Protein Coding	13.25	DISEASES inferred ¹⁵
12	TP53	Tumor Protein P53	Protein Coding	13.06	DISEASES inferred ¹⁵
13	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	5.14	DISEASES inferred ¹⁵
14	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	4.82	DISEASES inferred ¹⁵
15	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	4.76	DISEASES inferred ¹⁵
16	KANTR	KDM5C Adjacent Transcript	RNA Gene	4.55	DISEASES inferred ¹⁵
17	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	4.28	DISEASES inferred ¹⁵
18	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	3.22	DISEASES inferred ¹⁵

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Variations for Chronic Salpingitis

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Expression for Chronic Salpingitis

Search GEO for disease gene expression data for Chronic Salpingitis.

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Pathways for Chronic Salpingitis

Pathways related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	12.84	BAK1 CSH1 CSH2 MCL1 TNF TNFRSF1A
2	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ¹ Apoptosis ³⁷ Apoptosis and survival Apoptotic TNF-family pathways ²² Apoptosis Signaling Pathways ⁶⁵ Death Receptor Signaling ⁶⁷	12.46	BAK1 BLK HRK MCL1 TNF TNFRSF1A
3	NF-kappaB Signaling ⁴	12.43	BLK TNF TNFRSF1A TNFRSF1B
4	4-1BB Pathway ⁶⁴ Show member pathways CD27 Pathway ⁶⁴ CD40 Signaling ⁶⁴ CMV and MAPK Pathways ⁶⁴ NF-KappaB Activation by EBV ⁶⁴ NF-kappaB Activation by Viruses ⁶⁴ PKR Pathway ⁶⁴ SUMO Pathway ⁶⁴ TNFR2 Pathway ⁶⁴	12.4	BAK1 HRK MCL1 TNF TNFRSF1A TNFRSF1B
5	mTOR signaling pathway (KEGG) ⁶⁵ Show member pathways mTOR signaling pathway ³⁷	12.35	TNF TNFRSF1A TNFRSF1B TP53
6	Human T-cell leukemia virus 1 infection ³⁷	12.28	SLC2A1 TNF TNFRSF1A TP53
7	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.26	BLK CSH1 CSH2 MCL1
8	Apoptosis and Autophagy ⁴	12.03	BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
9	Direct p53 effectors ¹	11.93	BAK1 MCL1 TP53
10	Hepatitis C ³⁷	11.92	TNF TNFRSF1A TP53
11	Sphingolipid signaling pathway ³⁷	11.87	TNF TNFRSF1A TP53
12	Amyotrophic lateral sclerosis (ALS) ¹ ³⁷ Show member pathways Pathogenesis of ALS ⁶⁴	11.85	TNF TNFRSF1A TNFRSF1B TP53
13	Interleukin-4 and 13 signaling ⁶⁶	11.84	MCL1 TNF TNFRSF1B TP53
14	TNF signaling pathway ³⁷	11.83	TNF TNFRSF1A TNFRSF1B
15	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.82	SLC2A1 TNF TNFRSF1A
16	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ Apoptosis - multiple species ³⁷ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶	11.68	BAK1 MCL1 TNFRSF1A
17	Validated targets of C-MYC transcriptional activation ¹	11.65	HSPA4 SLC2A1 TP53
18	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²²	11.6	TNF TNFRSF1A TNFRSF1B
19	Adipocytokine signaling pathway ³⁷	11.54	SLC2A1 TNF TNFRSF1A TNFRSF1B
20	Transcription_NF-kB signaling pathway ²²	11.46	TNF TNFRSF1A TNFRSF1B
21	Interleukin-10 signaling ⁶⁶	11.4	TNF TNFRSF1A TNFRSF1B
22	Signal transduction_JNK pathway ²²	11.34	TNF TNFRSF1A TP53
23	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins ²² Show member pathways Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization ⁶⁶	11.29	BAK1 HRK MCL1 TNFRSF1A
24	14-3-3 and Regulation of BAD Activity ⁶⁴	11.19	TNF TNFRSF1A TNFRSF1B
25	Photodynamic therapy-induced HIF-1 survival signaling ¹	11.19	BAK1 MCL1 SLC2A1 TP53
26	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.06	BAK1 MCL1 TNF TNFRSF1A TP53
27	Regulation of Apoptosis by Parathyroid Hormone-related Protein ¹	10.98	BAK1 MCL1
28	Cellular Transformation by HTLV1 ⁶⁴ Show member pathways Activation of NF-KappaB by PKR ⁶⁴	10.72	HSPA4 SLC2A1 TNF TNFRSF1A TNFRSF1B

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GO Terms for Chronic Salpingitis

Cellular components related to Chronic Salpingitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.7	AVPR2 BAK1 CSH1 CSH2 CTSA LARS
2	membrane raft	GO:0045121	9.26	SLC2A1 TNF TNFRSF1A TNFRSF1B
3	tumor necrosis factor receptor superfamily complex	GO:0002947	8.62	TNFRSF1A TNFRSF1B

Biological processes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of apoptotic process	GO:0043065	9.92	BAK1 HRK TNF TP53
2	apoptotic process	GO:0006915	9.91	BAK1 HRK MCL1 TNFRSF1A TNFRSF1B TP53
3	regulation of apoptotic process	GO:0042981	9.87	BAK1 HRK MCL1 TP53
4	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.77	CSH1 CSH2 TP53
5	cellular response to mechanical stimulus	GO:0071260	9.72	BAK1 SLC2A1 TNFRSF1A
6	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.7	CSH1 CSH2 TNFRSF1A
7	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.69	TNF TNFRSF1A TNFRSF1B
8	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.65	AVPR2 TNF TNFRSF1A
9	negative regulation of cardiac muscle hypertrophy	GO:0010614	9.61	TNFRSF1A TNFRSF1B
10	animal organ development	GO:0048513	9.61	CSH1 CSH2
11	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.6	TNF TNFRSF1B
12	growth hormone receptor signaling pathway	GO:0060396	9.58	CSH1 CSH2
13	positive regulation of growth	GO:0045927	9.58	CSH1 CSH2
14	regulation of mitochondrial membrane permeability	GO:0046902	9.56	BAK1 TP53
15	cytokine-mediated signaling pathway	GO:0019221	9.55	MCL1 TNF TNFRSF1A TNFRSF1B TP53
16	positive regulation of ceramide biosynthetic process	GO:2000304	9.54	TNF TNFRSF1A
17	death-inducing signaling complex assembly	GO:0071550	9.49	TNF TNFRSF1A
18	regulation of establishment of endothelial barrier	GO:1903140	9.46	TNF TNFRSF1A
19	aortic valve development	GO:0003176	9.4	TNFRSF1A TNFRSF1B
20	negative regulation of extracellular matrix constituent secretion	GO:0003332	9.37	TNFRSF1A TNFRSF1B
21	positive regulation of apoptotic process involved in morphogenesis	GO:1902339	9.32	TNFRSF1A TNFRSF1B
22	pulmonary valve development	GO:0003177	9.26	TNFRSF1A TNFRSF1B
23	positive regulation of release of cytochrome c from mitochondria	GO:0090200	9.13	BAK1 HRK TP53
24	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.02	BAK1 MCL1 TNF TNFRSF1A TNFRSF1B

Molecular functions related to Chronic Salpingitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone receptor binding	GO:0005131	9.16	CSH1 CSH2
2	tumor necrosis factor-activated receptor activity	GO:0005031	8.96	TNFRSF1A TNFRSF1B
3	tumor necrosis factor binding	GO:0043120	8.62	TNFRSF1A TNFRSF1B

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