MCID: CHR099
MIFTS: 35

Chronic Salpingitis

Categories: Reproductive diseases

Aliases & Classifications for Chronic Salpingitis

MalaCards integrated aliases for Chronic Salpingitis:

Name: Chronic Salpingitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5731
ICD10 33 N70.11
NCIt 50 C40118
SNOMED-CT 68 55551005
UMLS 73 C0269041

Summaries for Chronic Salpingitis

MalaCards based summary : Chronic Salpingitis is related to salpingitis isthmica nodosa and salpingitis. An important gene associated with Chronic Salpingitis is OVGP1 (Oviductal Glycoprotein 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Modulation and Signaling. Affiliated tissues include lung, skin and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Chronic Salpingitis

Diseases in the Salpingitis family:

Acute Salpingitis Chronic Salpingitis

Diseases related to Chronic Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 salpingitis isthmica nodosa 32.1 AVPR2 HSPA4 KANTR
2 salpingitis 31.1 OVGP1 TNF
3 chronic gonococcal salpingitis 30.8 BAK1 BLK CLEC2A CTSA HRK MCL1
4 chronic salpingo-oophoritis 11.7
5 acute gonococcal salpingitis 10.3 CTSA TNF
6 retinitis pigmentosa 75 10.2 TNF TNFRSF1A
7 skin sarcoidosis 10.2 TNF TNFRSF1B
8 juvenile ankylosing spondylitis 10.2 TNF TNFRSF1B
9 granulomatous dermatitis 10.2 TNF TNFRSF1B
10 scleral disease 10.2 TNF TNFRSF1B
11 pericoronitis 10.2 TNFRSF1A TNFRSF1B
12 pustulosis of palm and sole 10.2 TNF TNFRSF1B
13 rheumatoid lung disease 10.2 TNF TNFRSF1B
14 necrobiosis lipoidica 10.2 SLC2A1 TNFRSF1B
15 peroneal neuropathy 10.2 TNF TNFRSF1B
16 atrophy of prostate 10.2 SLC2A1 TP53
17 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1A TNFRSF1B
18 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1A TNFRSF1B
19 palindromic rheumatism 10.1 TNF TNFRSF1A TNFRSF1B
20 guillain-barre syndrome 10.1 TNF TNFRSF1A TNFRSF1B
21 thyroid lymphoma 10.1 TNF TP53
22 chlamydia 10.1
23 relapsing fever 10.1 TNF TNFRSF1A
24 trench fever 10.1 KANTR TNF
25 psoriatic arthritis 10.1 TNF TNFRSF1A TNFRSF1B
26 leukocyte disease 10.1 MCL1 TNF TP53
27 glomangiosarcoma 10.1 KANTR TP53
28 testicular trophoblastic tumor 10.0 CSH1 CSH2
29 cogan syndrome 10.0 HSPA4 TNF TNFRSF1B
30 choriocarcinoma of ovary 10.0 CSH1 CSH2
31 sciatic neuropathy 10.0 KANTR TNFRSF1A TNFRSF1B
32 cochlear disease 10.0 KANTR TNFRSF1B
33 dystrophinopathies 10.0 TNF TNFRSF1A
34 large intestine cancer 10.0 LARS SLC2A1 TNF TP53
35 acute vascular insufficiency of intestine 10.0 HSPA4 TNF
36 non-gestational choriocarcinoma 9.9 CSH1 CSH2
37 choriocarcinoma of the testis 9.9 CSH1 CSH2
38 lymphoma, non-hodgkin, familial 9.9 BAK1 MCL1 TNFRSF1A TP53
39 germ cell and embryonal cancer 9.9 CSH1 CSH2 TP53
40 uterine anomalies 9.9 CSH1 CSH2 TP53
41 endometriosis 9.9
42 adenomatoid tumor 9.9
43 nervous system disease 9.9 KANTR TNF TP53
44 female reproductive system disease 9.8 CSH1 CSH2 TNF TP53
45 acute salpingitis 9.3 BAK1 BLK CLEC2A CTSA HRK MCL1

Graphical network of the top 20 diseases related to Chronic Salpingitis:



Diseases related to Chronic Salpingitis

Symptoms & Phenotypes for Chronic Salpingitis

GenomeRNAi Phenotypes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.74 HRK MCL1 TNF TNFRSF1A TNFRSF1B TP53
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.74 HRK MCL1 TNF TNFRSF1A TNFRSF1B TP53

MGI Mouse Phenotypes related to Chronic Salpingitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 BAK1 BLK HSPA4 MCL1 TNF TNFRSF1A
2 reproductive system MP:0005389 9.28 BAK1 BLK CTSA HSPA4 MCL1 OVGP1

Drugs & Therapeutics for Chronic Salpingitis

Search Clinical Trials , NIH Clinical Center for Chronic Salpingitis

Genetic Tests for Chronic Salpingitis

Anatomical Context for Chronic Salpingitis

MalaCards organs/tissues related to Chronic Salpingitis:

41
Lung, Skin, Ovary, Spinal Cord, Prostate, Thyroid, Testis

Publications for Chronic Salpingitis

Articles related to Chronic Salpingitis:

(show all 16)
# Title Authors Year
1
Tracing GFP-labeled WJMSCs in vivo using a chronic salpingitis model: an animal experiment. ( 29191249 )
2017
2
Treatment evaluation of Wharton's jelly-derived mesenchymal stem cells using a chronic salpingitis model: an animal experiment. ( 29041961 )
2017
3
An incidental finding of chronic salpingitis complications: Tubo-uterine fistula. ( 28976128 )
2017
4
Isolated Tubal Torsion in Patient With Chronic Salpingitis: A Challenging Diagnosis. ( 27678759 )
2015
5
Therapeutic influence of intraperitoneal injection of Wharton's jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis. ( 25966129 )
2015
6
"Tubal ostium sunshine": hysteroscopic sign of chronic salpingitis. ( 23084667 )
2012
7
Detection of Chlamydia trachomatis DNA in archival paraffinized specimens from chronic salpingitis cases using the polymerase chain reaction. ( 10899513 )
2000
8
Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion. ( 9797114 )
1998
9
Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. ( 8815069 )
1996
10
Postsalpingostomy intercornual bridging with hematosalpinx, chronic salpingitis and perisalpingeal endometriosis. A case report. ( 1564706 )
1992
11
Chronic salpingitis. ( 5905411 )
1966
12
Adenomatoid tumor of the fallopian tube associated with chronic salpingitis. ( 14771022 )
1950
13
Chronic salpingitis. ( 20284795 )
1947
14
Treatment of chronic salpingitis with benzyl cinnamate ester (Jacobson's solution). ( 20252991 )
1947
15
The Treatment of Acute and Chronic Salpingitis. ( 20322471 )
1942
16
Chronic Salpingitis: Hysterosalpingectomy in Its Operative Treatment. ( 18745558 )
1940

Variations for Chronic Salpingitis

Expression for Chronic Salpingitis

Search GEO for disease gene expression data for Chronic Salpingitis.

Pathways for Chronic Salpingitis

Pathways related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 BAK1 CSH1 CSH2 MCL1 TNF TNFRSF1A
2
Show member pathways
12.46 BAK1 BLK HRK MCL1 TNF TNFRSF1A
3 12.43 BLK TNF TNFRSF1A TNFRSF1B
4
Show member pathways
12.4 BAK1 HRK MCL1 TNF TNFRSF1A TNFRSF1B
5
Show member pathways
12.35 TNF TNFRSF1A TNFRSF1B TP53
6 12.28 SLC2A1 TNF TNFRSF1A TP53
7
Show member pathways
12.26 BLK CSH1 CSH2 MCL1
8 12.03 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
9 11.93 BAK1 MCL1 TP53
10 11.92 TNF TNFRSF1A TP53
11 11.87 TNF TNFRSF1A TP53
12
Show member pathways
11.85 TNF TNFRSF1A TNFRSF1B TP53
13 11.84 MCL1 TNF TNFRSF1B TP53
14 11.83 TNF TNFRSF1A TNFRSF1B
15
Show member pathways
11.82 SLC2A1 TNF TNFRSF1A
16
Show member pathways
11.68 BAK1 MCL1 TNFRSF1A
17 11.65 HSPA4 SLC2A1 TP53
18
Show member pathways
11.6 TNF TNFRSF1A TNFRSF1B
19 11.54 SLC2A1 TNF TNFRSF1A TNFRSF1B
20 11.46 TNF TNFRSF1A TNFRSF1B
21 11.4 TNF TNFRSF1A TNFRSF1B
22 11.34 TNF TNFRSF1A TP53
23
Show member pathways
11.29 BAK1 HRK MCL1 TNFRSF1A
24 11.19 TNF TNFRSF1A TNFRSF1B
25 11.19 BAK1 MCL1 SLC2A1 TP53
26 11.06 BAK1 MCL1 TNF TNFRSF1A TP53
28
Show member pathways
10.72 HSPA4 SLC2A1 TNF TNFRSF1A TNFRSF1B

GO Terms for Chronic Salpingitis

Cellular components related to Chronic Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.7 AVPR2 BAK1 CSH1 CSH2 CTSA LARS
2 membrane raft GO:0045121 9.26 SLC2A1 TNF TNFRSF1A TNFRSF1B
3 tumor necrosis factor receptor superfamily complex GO:0002947 8.62 TNFRSF1A TNFRSF1B

Biological processes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.92 BAK1 HRK TNF TP53
2 apoptotic process GO:0006915 9.91 BAK1 HRK MCL1 TNFRSF1A TNFRSF1B TP53
3 regulation of apoptotic process GO:0042981 9.87 BAK1 HRK MCL1 TP53
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 CSH1 CSH2 TP53
5 cellular response to mechanical stimulus GO:0071260 9.72 BAK1 SLC2A1 TNFRSF1A
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.7 CSH1 CSH2 TNFRSF1A
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.69 TNF TNFRSF1A TNFRSF1B
8 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.65 AVPR2 TNF TNFRSF1A
9 negative regulation of cardiac muscle hypertrophy GO:0010614 9.61 TNFRSF1A TNFRSF1B
10 animal organ development GO:0048513 9.61 CSH1 CSH2
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 TNF TNFRSF1B
12 growth hormone receptor signaling pathway GO:0060396 9.58 CSH1 CSH2
13 positive regulation of growth GO:0045927 9.58 CSH1 CSH2
14 regulation of mitochondrial membrane permeability GO:0046902 9.56 BAK1 TP53
15 cytokine-mediated signaling pathway GO:0019221 9.55 MCL1 TNF TNFRSF1A TNFRSF1B TP53
16 positive regulation of ceramide biosynthetic process GO:2000304 9.54 TNF TNFRSF1A
17 death-inducing signaling complex assembly GO:0071550 9.49 TNF TNFRSF1A
18 regulation of establishment of endothelial barrier GO:1903140 9.46 TNF TNFRSF1A
19 aortic valve development GO:0003176 9.4 TNFRSF1A TNFRSF1B
20 negative regulation of extracellular matrix constituent secretion GO:0003332 9.37 TNFRSF1A TNFRSF1B
21 positive regulation of apoptotic process involved in morphogenesis GO:1902339 9.32 TNFRSF1A TNFRSF1B
22 pulmonary valve development GO:0003177 9.26 TNFRSF1A TNFRSF1B
23 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.13 BAK1 HRK TP53
24 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.02 BAK1 MCL1 TNF TNFRSF1A TNFRSF1B

Molecular functions related to Chronic Salpingitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth hormone receptor binding GO:0005131 9.16 CSH1 CSH2
2 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF1A TNFRSF1B
3 tumor necrosis factor binding GO:0043120 8.62 TNFRSF1A TNFRSF1B

Sources for Chronic Salpingitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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