Chronic Salpingitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CHR099 MIFTS: 35	Chronic Salpingitis Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Chronic Salpingitis

MalaCards integrated aliases for Chronic Salpingitis:

Name: Chronic Salpingitis ¹² ¹⁵ ⁷⁴

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5731

NCIt ⁵¹ C40118

SNOMED-CT ⁶⁹ 55551005

ICD10 ³⁴ N70.11

UMLS ⁷⁴ C0269041

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Summaries for Chronic Salpingitis

MalaCards based summary : Chronic Salpingitis is related to salpingitis isthmica nodosa and salpingitis. An important gene associated with Chronic Salpingitis is OVGP1 (Oviductal Glycoprotein 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Apoptosis Modulation and Signaling. Affiliated tissues include skin, breast and ovary, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

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Related Diseases for Chronic Salpingitis

Diseases in the Salpingitis family:

Acute Salpingitis

Chronic Salpingitis

Diseases related to Chronic Salpingitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)

#	Related Disease	Score	Top Affiliating Genes
1	salpingitis isthmica nodosa	32.1	AVPR2 HSPA4 KANTR
2	salpingitis	31.4	OVGP1 TNF
3	chronic gonococcal salpingitis	30.3	BAK1 BLK CLEC2A CTSA HRK MCL1
4	chronic salpingo-oophoritis	11.7
5	acute gonococcal salpingitis	10.4	CTSA TNF
6	autoimmune myocarditis	10.4	TNF TNFRSF1A
7	skin sarcoidosis	10.3	TNF TNFRSF1B
8	juvenile ankylosing spondylitis	10.3	TNF TNFRSF1B
9	retinitis pigmentosa 75	10.3	TNF TNFRSF1A
10	pericoronitis	10.3	TNFRSF1A TNFRSF1B
11	granulomatous dermatitis	10.3	TNF TNFRSF1B
12	scleral disease	10.3	TNF TNFRSF1B
13	pustulosis of palm and sole	10.3	TNF TNFRSF1B
14	necrobiosis lipoidica	10.3	SLC2A1 TNFRSF1B
15	atrophy of prostate	10.3	SLC2A1 TP53
16	periodic fever, familial, autosomal dominant	10.2	TNF TNFRSF1A TNFRSF1B
17	post-transplant lymphoproliferative disease	10.2	TNF TNFRSF1A TNFRSF1B
18	peroneal neuropathy	10.2	TNF TNFRSF1B
19	palindromic rheumatism	10.2	TNF TNFRSF1A TNFRSF1B
20	guillain-barre syndrome	10.2	TNF TNFRSF1A TNFRSF1B
21	uterine corpus serous adenocarcinoma	10.2	BRCA1 TP53
22	chlamydia	10.2
23	synchronous bilateral breast carcinoma	10.1	BRCA1 TP53
24	reproductive system disease	10.1	BRCA1 TNF TP53
25	thyroid lymphoma	10.1	TNF TP53
26	trench fever	10.1	KANTR TNF
27	papillary serous adenocarcinoma	10.1	BRCA1 TP53
28	glomangiosarcoma	10.1	KANTR TP53
29	leukocyte disease	10.1	MCL1 TNF TP53
30	testicular trophoblastic tumor	10.1	CSH1 CSH2
31	cogan syndrome	10.1	HSPA4 TNF TNFRSF1B
32	sciatic neuropathy	10.0	KANTR TNFRSF1A TNFRSF1B
33	choriocarcinoma of ovary	10.0	CSH1 CSH2
34	psoriatic arthritis	9.9	TNF TNFRSF1A TNFRSF1B
35	cochlear disease	9.9	KANTR TNFRSF1B
36	large intestine cancer	9.9	LARS SLC2A1 TNF TP53
37	endometriosis	9.9
38	adenomatoid tumor	9.9
39	germ cell and embryonal cancer	9.9	CSH1 CSH2 TP53
40	lymphoma, non-hodgkin, familial	9.8	BAK1 MCL1 TNFRSF1A TP53
41	uterine anomalies	9.8	CSH1 CSH2 TP53
42	nervous system disease	9.5	KANTR TNF TP53
43	female reproductive system disease	9.5	BRCA1 CSH1 CSH2 TNF TP53
44	acute salpingitis	8.9	BAK1 BLK CLEC2A CTSA HRK MCL1

Graphical network of the top 20 diseases related to Chronic Salpingitis:

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Symptoms & Phenotypes for Chronic Salpingitis

GenomeRNAi Phenotypes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.8	BRCA1 HRK MCL1 TNF TNFRSF1A TNFRSF1B
2	Synthetic lethal with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.8	BRCA1 HRK MCL1 TNF TNFRSF1A TNFRSF1B

MGI Mouse Phenotypes related to Chronic Salpingitis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.16	AVPR2 BAK1 BRCA1 CTSA HSPA4 SLC2A1
2	cellular	MP:0005384	10.13	BAK1 BRCA1 CTSA HSPA4 MCL1 SLC2A1
3	hematopoietic system	MP:0005397	10.07	AVPR2 BAK1 BLK BRCA1 CTSA MCL1
4	endocrine/exocrine gland	MP:0005379	10.06	BAK1 BLK BRCA1 HSPA4 MCL1 TNF
5	mortality/aging	MP:0010768	10.03	AVPR2 BAK1 BRCA1 CTSA HSPA4 LARS
6	integument	MP:0010771	9.92	AVPR2 BRCA1 CTSA MCL1 TNF TNFRSF1A
7	neoplasm	MP:0002006	9.63	BAK1 BRCA1 TNF TNFRSF1A TNFRSF1B TP53
8	renal/urinary system	MP:0005367	9.5	AVPR2 BAK1 BRCA1 CTSA TNFRSF1A TNFRSF1B
9	reproductive system	MP:0005389	9.32	BAK1 BLK BRCA1 CTSA HSPA4 MCL1

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Drugs & Therapeutics for Chronic Salpingitis

Search Clinical Trials , NIH Clinical Center for Chronic Salpingitis

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Genetic Tests for Chronic Salpingitis

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Anatomical Context for Chronic Salpingitis

MalaCards organs/tissues related to Chronic Salpingitis:

⁴²

Skin, Breast, Ovary, Prostate, Thyroid

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Publications for Chronic Salpingitis

Articles related to Chronic Salpingitis:

(show all 16)

#	Title	Authors	Year
1	An incidental finding of chronic salpingitis complications: Tubo-uterine fistula. ( 28976128 )	Tokmak A...Sar?kaya E	2017
2	Treatment evaluation of Wharton's jelly-derived mesenchymal stem cells using a chronic salpingitis model: an animal experiment. ( 29041961 )	Li Z...Xiao XM	2017
3	Tracing GFP-labeled WJMSCs in vivo using a chronic salpingitis model: an animal experiment. ( 29191249 )	Li Z...Xiao XM	2017
4	Therapeutic influence of intraperitoneal injection of Wharton's jelly-derived mesenchymal stem cells on oviduct function and fertility in rats with acute and chronic salpingitis. ( 25966129 )	Luo HJ...Wei W	2015
5	Isolated Tubal Torsion in Patient With Chronic Salpingitis: A Challenging Diagnosis. ( 27678759 )	Pecorini F...Benedetti Panici P	2015
6	"Tubal ostium sunshine": hysteroscopic sign of chronic salpingitis. ( 23084667 )	Di Spiezio Sardo A...Nappi C	2012
7	Detection of Chlamydia trachomatis DNA in archival paraffinized specimens from chronic salpingitis cases using the polymerase chain reaction. ( 10899513 )	Hinton EL...Viscidi RP	2000
8	Presence of the major outer-membrane protein of Chlamydia trachomatis in patients with chronic salpingitis and salpingitis isthmica nodosa with tubal occlusion. ( 9797114 )	Dieterle S...Fenner T	1998
9	Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. ( 8815069 )	Dieterle S...Wollenhaupt J	1996
10	Postsalpingostomy intercornual bridging with hematosalpinx, chronic salpingitis and perisalpingeal endometriosis. A case report. ( 1564706 )	Honor? LH...Scott JZ	1992
11	Chronic salpingitis. ( 5905411 )	Pinkerton JH	1966
12	Adenomatoid tumor of the fallopian tube associated with chronic salpingitis. ( 14771022 )	LEACH WB	1950
13	Treatment of chronic salpingitis with benzyl cinnamate ester (Jacobson's solution). ( 20252991 )	EISENSTEIN MI...BENDO GJ	1947
14	Chronic salpingitis. ( 20284795 )	SHAW HN...GASPAR J	1947
15	The Treatment of Acute and Chronic Salpingitis. ( 20322471 )	Nash AB	1942
16	Chronic Salpingitis: Hysterosalpingectomy in Its Operative Treatment. ( 18745558 )	McDermott JC	1940

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Genes for Chronic Salpingitis

Genes related to Chronic Salpingitis (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	OVGP1	Oviductal Glycoprotein 1	Protein Coding	16.56	DISEASES inferred ¹⁵
2	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	14.87	DISEASES inferred ¹⁵
3	CTSA	Cathepsin A	Protein Coding	14.5	DISEASES inferred ¹⁵
4	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	14.44	DISEASES inferred ¹⁵
5	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	14.33	DISEASES inferred ¹⁵
6	LARS	Leucyl-TRNA Synthetase	Protein Coding	14.24	DISEASES inferred ¹⁵
7	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	13.97	DISEASES inferred ¹⁵
8	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	13.87	DISEASES inferred ¹⁵
9	TNF	Tumor Necrosis Factor	Protein Coding	13.72	DISEASES inferred ¹⁵
10	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	13.5	DISEASES inferred ¹⁵
11	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	13.36	DISEASES inferred ¹⁵
12	MCL1	MCL1 Apoptosis Regulator, BCL2 Family Member	Protein Coding	13.26	DISEASES inferred ¹⁵
13	TP53	Tumor Protein P53	Protein Coding	13.2	DISEASES inferred ¹⁵
14	HRK	Harakiri, BCL2 Interacting Protein	Protein Coding	5.12	DISEASES inferred ¹⁵
15	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	4.83	DISEASES inferred ¹⁵
16	CLEC2A	C-Type Lectin Domain Family 2 Member A	Protein Coding	4.8	DISEASES inferred ¹⁵
17	KANTR	KDM5C Adjacent Transcript	RNA Gene	4.57	DISEASES inferred ¹⁵
18	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	4.32	DISEASES inferred ¹⁵
19	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	3.23	DISEASES inferred ¹⁵

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Variations for Chronic Salpingitis

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Expression for Chronic Salpingitis

Search GEO for disease gene expression data for Chronic Salpingitis.

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Pathways for Chronic Salpingitis

Pathways related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 28)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.76	BAK1 BRCA1 CSH1 CSH2 MCL1 TNF
2	Apoptosis Modulation and Signaling ¹ Show member pathways Apoptosis ³⁸ Apoptosis ¹ Apoptosis and survival Apoptotic TNF-family pathways ²³ Apoptosis Signaling Pathways ⁶⁶ Death Receptor Signaling ⁶⁸	12.46	BAK1 BLK HRK MCL1 TNF TNFRSF1A
3	NF-kappaB Signaling ⁴	12.44	BLK TNF TNFRSF1A TNFRSF1B
4	4-1BB Pathway ⁶⁵ Show member pathways CD27 Pathway ⁶⁵ CD40 Signaling ⁶⁵ CMV and MAPK Pathways ⁶⁵ NF-KappaB Activation by EBV ⁶⁵ NF-kappaB Activation by Viruses ⁶⁵ PKR Pathway ⁶⁵ SUMO Pathway ⁶⁵ TNFR2 Pathway ⁶⁵	12.4	BAK1 HRK MCL1 TNF TNFRSF1A TNFRSF1B
5	MicroRNAs in cancer ³⁸	12.39	BAK1 BRCA1 MCL1 TP53
6	mTOR signaling pathway (KEGG) ³⁸ Show member pathways mTOR Signaling Pathway ⁶⁶	12.36	TNF TNFRSF1A TNFRSF1B TP53
7	JAK-STAT signaling pathway (KEGG) ⁶⁶ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁷ JAK-STAT signaling pathway ³⁸	12.27	BLK CSH1 CSH2 MCL1
8	Human T-cell leukemia virus 1 infection ³⁸	12.23	SLC2A1 TNF TNFRSF1A TP53
9	Apoptosis and Autophagy ⁴	12.07	BAK1 MCL1 TNF TNFRSF1A TNFRSF1B
10	Sphingolipid signaling pathway ³⁸	11.88	TNF TNFRSF1A TP53
11	Amyotrophic lateral sclerosis (ALS) ¹ ³⁸ Show member pathways Pathogenesis of ALS ⁶⁵	11.85	TNF TNFRSF1A TNFRSF1B TP53
12	TNF signaling pathway ³⁸	11.84	TNF TNFRSF1A TNFRSF1B
13	Interleukin-4 and 13 signaling ⁶⁷	11.84	MCL1 TNF TNFRSF1B TP53
14	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.83	SLC2A1 TNF TNFRSF1A
15	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁷ Apoptosis - multiple species ³⁸ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁷ Release of apoptotic factors from the mitochondria ⁶⁷	11.68	BAK1 MCL1 TNFRSF1A
16	Validated targets of C-MYC transcriptional activation ¹	11.66	HSPA4 SLC2A1 TP53
17	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.61	TNF TNFRSF1A TNFRSF1B
18	Platinum drug resistance ³⁸	11.6	BAK1 BRCA1 TP53
19	Adipocytokine signaling pathway ³⁸	11.57	SLC2A1 TNF TNFRSF1A TNFRSF1B
20	Transcription_NF-kB signaling pathway ²³	11.46	TNF TNFRSF1A TNFRSF1B
21	Interleukin-10 signaling ⁶⁷	11.4	TNF TNFRSF1A TNFRSF1B
22	Signal transduction_JNK pathway ²³	11.34	TNF TNFRSF1A TP53
23	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins ²³ Show member pathways Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization ⁶⁷	11.31	BAK1 HRK MCL1 TNFRSF1A
24	Photodynamic therapy-induced HIF-1 survival signaling ¹	11.24	BAK1 MCL1 SLC2A1 TP53
25	14-3-3 and Regulation of BAD Activity ⁶⁵	11.19	TNF TNFRSF1A TNFRSF1B
26	Photodynamic therapy-induced AP-1 survival signaling. ¹	11.06	BAK1 MCL1 TNF TNFRSF1A TP53
27	DNA Damage Induced 14-3-3Sigma Signaling ⁶⁵	10.92	BRCA1 TP53
28	Cellular Transformation by HTLV1 ⁶⁵ Show member pathways Activation of NF-KappaB by PKR ⁶⁵	10.72	HSPA4 SLC2A1 TNF TNFRSF1A TNFRSF1B

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GO Terms for Chronic Salpingitis

Cellular components related to Chronic Salpingitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum	GO:0005783	9.7	AVPR2 BAK1 CSH1 CSH2 CTSA LARS
2	membrane raft	GO:0045121	9.26	SLC2A1 TNF TNFRSF1A TNFRSF1B
3	tumor necrosis factor receptor superfamily complex	GO:0002947	8.62	TNFRSF1A TNFRSF1B

Biological processes related to Chronic Salpingitis according to GeneCards Suite gene sharing:

(show all 24)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.77	CSH1 CSH2 TP53
2	cellular response to mechanical stimulus	GO:0071260	9.73	BAK1 SLC2A1 TNFRSF1A
3	cytokine-mediated signaling pathway	GO:0019221	9.72	MCL1 TNF TNFRSF1A TNFRSF1B TP53
4	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.71	CSH1 CSH2 TNFRSF1A
5	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.7	TNF TNFRSF1A TNFRSF1B
6	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.67	AVPR2 TNF TNFRSF1A
7	negative regulation of cardiac muscle hypertrophy	GO:0010614	9.62	TNFRSF1A TNFRSF1B
8	animal organ development	GO:0048513	9.61	CSH1 CSH2
9	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.61	TNF TNFRSF1B
10	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.6	BRCA1 TP53
11	growth hormone receptor signaling pathway	GO:0060396	9.58	CSH1 CSH2
12	positive regulation of growth	GO:0045927	9.58	CSH1 CSH2
13	regulation of mitochondrial membrane permeability	GO:0046902	9.57	BAK1 TP53
14	positive regulation of ceramide biosynthetic process	GO:2000304	9.55	TNF TNFRSF1A
15	regulation of apoptotic process	GO:0042981	9.55	BAK1 BRCA1 HRK MCL1 TP53
16	death-inducing signaling complex assembly	GO:0071550	9.51	TNF TNFRSF1A
17	apoptotic process	GO:0006915	9.5	BAK1 BRCA1 HRK MCL1 TNFRSF1A TNFRSF1B
18	regulation of establishment of endothelial barrier	GO:1903140	9.48	TNF TNFRSF1A
19	aortic valve development	GO:0003176	9.46	TNFRSF1A TNFRSF1B
20	negative regulation of extracellular matrix constituent secretion	GO:0003332	9.43	TNFRSF1A TNFRSF1B
21	positive regulation of release of cytochrome c from mitochondria	GO:0090200	9.43	BAK1 HRK TP53
22	positive regulation of apoptotic process involved in morphogenesis	GO:1902339	9.4	TNFRSF1A TNFRSF1B
23	pulmonary valve development	GO:0003177	9.37	TNFRSF1A TNFRSF1B
24	intrinsic apoptotic signaling pathway in response to DNA damage	GO:0008630	9.1	BAK1 BRCA1 MCL1 TNF TNFRSF1A TNFRSF1B

Molecular functions related to Chronic Salpingitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth hormone receptor binding	GO:0005131	9.16	CSH1 CSH2
2	tumor necrosis factor-activated receptor activity	GO:0005031	8.96	TNFRSF1A TNFRSF1B
3	tumor necrosis factor binding	GO:0043120	8.62	TNFRSF1A TNFRSF1B

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Sources for Chronic Salpingitis

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