MCID: CHR466
MIFTS: 44

Chronic Thromboembolic Pulmonary Hypertension

Categories: Blood diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

MalaCards integrated aliases for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 54 38 74
Cteph 54

Classifications:



External Ids:

KEGG 38 H01622
UMLS 74 C2363973

Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 54 Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. Signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). The disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). However, up to 60% of patients have no history of acute pulmonary embolism. Some people with this disease may have clotting problems. Research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific genemutations have been identified in CTEPH. Curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow). 

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to pulmonary hypertension and pulmonary embolism. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Collagen chain trimerization and Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotype is cardiovascular system.

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 pulmonary hypertension 31.8 BMPR2 EDN1 NPPB
2 pulmonary embolism 31.1 CRP NPPB
3 pulmonary hypertension, primary, 1 30.4 BMPR2 EDN1 FGA NPPB
4 dysfibrinogenemia 30.0 FGA FGB
5 eisenmenger syndrome 29.8 BMPR2 EDN1
6 sleep apnea 29.7 CRP EDN1 NPPB
7 coronary artery anomaly 29.4 CRP EDN1 NPPB
8 arteries, anomalies of 29.1 BMPR2 CRP EDN1 NPPB
9 heart disease 29.0 BMPR2 CRP EDN1 NPPB
10 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 12.2
11 hypertension, essential 10.9
12 thrombosis 10.4
13 antiphospholipid syndrome 10.3
14 sarcoma 10.2
15 rere-related disorders 10.2
16 ischemic heart disease 10.1 CRP NPPB
17 pericardial effusion 10.1 CRP NPPB
18 heart conduction disease 10.1 CRP NPPB
19 pericarditis 10.1 CRP NPPB
20 heart valve disease 10.1 CRP NPPB
21 sarcoidosis 1 10.1
22 muscle hypertrophy 10.1
23 thrombocytopenia 10.1
24 nephrotic syndrome 10.1
25 coronary stenosis 10.1 CRP NPPB
26 dysfibrinogenemia, congenital 10.1 FGA FGB
27 aortic valve disease 2 10.0 CRP NPPB
28 afibrinogenemia 10.0 FGA FGB
29 afibrinogenemia, congenital 10.0 FGA FGB
30 systemic lupus erythematosus 10.0
31 cystic fibrosis 10.0
32 lupus erythematosus 10.0
33 chronic mountain sickness 10.0 EDN1 NPPB
34 idiopathic edema 10.0 EDN1 NPPB
35 renal hypertension 10.0 EDN1 NPPB
36 kawasaki disease 9.9 CRP NPPB
37 cardiac arrhythmia 9.9
38 klippel-trenaunay-weber syndrome 9.9
39 prostate cancer 9.9
40 schizophrenia 9.9
41 takayasu arteritis 9.9
42 pulmonary arteriovenous fistulas 9.9
43 prostate cancer, hereditary, 8 9.9
44 homocysteinemia 9.9
45 pulmonary disease, chronic obstructive 9.9
46 resting heart rate, variation in 9.9
47 anxiety 9.9
48 prostate cancer, hereditary, 6 9.9
49 intraocular pressure quantitative trait locus 9.9
50 infantile liver failure syndrome 1 9.9

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 BMPR2 CRP EDN1 FGA FGB

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

# Drug Name Active Ingredient(s) 19 Company Approval Date
1
Adempas 19 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
2
Riociguat Approved Phase 3,Phase 2,Not Applicable 625115-55-1
3
Macitentan Approved Phase 3,Phase 2 441798-33-0
4
Selexipag Approved Phase 3 475086-01-2
5
Treprostinil Approved, Investigational Phase 3 81846-19-7 6918140 54786
6
Ambrisentan Approved, Investigational Phase 3 177036-94-1 6918493
7 Antihypertensive Agents Phase 3,Phase 2
8 Endothelin Receptor Antagonists Phase 3,Phase 2
9 Calamus Phase 3
10 Endothelin A Receptor Antagonists Phase 3,Phase 2
11 Radiopharmaceuticals Phase 2
12 Fluorodeoxyglucose F18 Phase 2
13 Protective Agents Phase 2
14 adrenomedullin Phase 2
15 Cardiotonic Agents Phase 2
16 Peripheral Nervous System Agents Phase 2
17 Autonomic Agents Phase 2
18 Respiratory System Agents Phase 2
19 Bronchodilator Agents Phase 2
20 Vasodilator Agents Phase 2
21 Anti-Asthmatic Agents Phase 2
22
Nitric Oxide Approved Phase 1 10102-43-9 145068
23
Iloprost Approved, Investigational Phase 1 78919-13-8 6443959
24
Thrombin Approved, Investigational
25
Warfarin Approved ,Not Applicable 81-81-2 54678486 6691
26
Rivaroxaban Approved 366789-02-8
27
Tadalafil Approved, Investigational 171596-29-5 110635
28
Iodine Approved, Investigational 7553-56-2 807
29 Menaquinone Approved, Investigational Not Applicable 1182-68-9
30
Phylloquinone Approved, Investigational Not Applicable 84-80-0
31
Edoxaban Approved Not Applicable 480449-70-5
32
Heparin Approved, Investigational Not Applicable 9005-49-6 46507594 772
33
Serine Approved, Nutraceutical ,Not Applicable 56-45-1 5951
34
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
35
Menadione Approved, Nutraceutical Not Applicable 58-27-5 4055
36 Tezosentan Investigational 180384-57-0
37 Anti-Infective Agents
38 Deoxyglucose
39 Antimetabolites
40 Antiviral Agents
41 Immunoglobulins Not Applicable
42 Autoantibodies Not Applicable
43 Antibodies Not Applicable
44 interferons Not Applicable
45 Anticoagulants ,Not Applicable
46 Hemostatics
47 Coagulants
48
protease inhibitors ,Not Applicable
49 HIV Protease Inhibitors ,Not Applicable
50 Factor Xa Inhibitors ,Not Applicable

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3 bosentan
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3 bosentan
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3 Riociguat (Adempas, BAY63-2521);Placebo
6 A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery Recruiting NCT03689244 Phase 3 Selexipag;Placebo
7 A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Recruiting NCT03809650 Phase 3 macitentan 10 mg
8 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
9 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3 Treprostinil sodium
10 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3 Riociguat (Adempas, BAY63-2521)
11 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3 Ambrisentan 5 mg;Placebo
12 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3 Ambrisentan 5 mg
13 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Unknown status NCT02745106 Phase 2
14 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2 Macitentan;Placebo
15 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
16 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
17 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2 Riociguat (Adempas, BAY63-2521)
18 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2 PulmoBind
19 Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Recruiting NCT03273257 Phase 2 Riociguat;Placebo
20 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2 Macitentan
21 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Active, not recruiting NCT02886793 Phase 1, Phase 2 fludeoxyglucose
22 This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Recruiting NCT03754660 Phase 1 BAY1237592;PH-monotherapy;PH-combination therapy
23 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Unknown status NCT02660463
24 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724 Not Applicable
25 Right Ventricular Resynchronization Therapy Unknown status NCT01163422 Not Applicable
26 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Unknown status NCT02964390 Not Applicable
27 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
28 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
29 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
30 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
31 Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and Rubidium-82 (82Rb) Positron Emission Tomography/Computed Tomography (PET/CTs) on Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Unknown status NCT02970851
32 CTEPH Identification an Standard Computerised Tomography Pulmonary Angiography in Pulmonary Embolism Patients Unknown status NCT03083093
33 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
34 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465 Riociguat (Adempas, BAY63-2521)
35 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045 Not Applicable
36 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
37 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
38 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722 Not Applicable
39 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
40 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980 Not Applicable
41 Right Ventricular Pulmonary Vascular Interaction in Pulmonary Hypertension Completed NCT03523910 Not Applicable
42 EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension Completed NCT02092818 Riociguat (Adempas, BAY63-2521)
43 Auto-immunity and Pulmonary Arterial Hypertension Completed NCT01208792 Not Applicable
44 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203 Not Applicable Riociguat
45 Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region Recruiting NCT03349164
46 Dyspnea in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03786367
47 Pulmonary Endarterectomy Guided by CT Scanning for Patients With Chronic Thromboembolic Pulmonary Hypertension----PEACT Recruiting NCT03795740 Not Applicable
48 Taiwan Cohort - Chronic ThromboEmbolic Pulmonary Hypertension Registry Recruiting NCT03667391
49 Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539 Not Applicable Riociguat
50 Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH) Recruiting NCT03719027 Not Applicable

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

42
Lung, Heart, Endothelial, Testes, Prostate, Kidney, Smooth Muscle

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 993)
# Title Authors Year
1
Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. ( 30747032 )
2019
2
Angioscopic Evaluation During Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension. ( 30224170 )
2019
3
Growing number of incident pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients in Latvia: a shifting epidemiological landscape? Data from a national pulmonary hypertension registry. ( 30279036 )
2019
4
Exercise Training After Pulmonary Endarterectomy for Patients with Chronic Thromboembolic Pulmonary Hypertension. ( 30293071 )
2019
5
Discordance between Imaging Modalities in the Evaluation of Chronic Thromboembolic Pulmonary Hypertension: A Combined Experience from Two Academic Medical Centers. ( 30359536 )
2019
6
Intraoperative 3-Dimensional Echocardiography-Derived Right Ventricular Volumetric Analysis in Chronic Thromboembolic Pulmonary Hypertension Patients Before and After Pulmonary Thromboendarterectomy. ( 30385197 )
2019
7
Increasing mixed venous oxygen saturation is a predictor of improved renal function after balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension. ( 30386916 )
2019
8
Response to letter from dr Altmayer regarding publication "Sequential treatment with sildenafil and riociguat in patients with persistent or inoperable chronic thromboembolic pulmonary hypertension improves functional class and pulmonary hemodynamics". ( 30414750 )
2019
9
Validation of a claims-based algorithm to identify patients with chronic thromboembolic pulmonary hypertension using electronic health record data. ( 30419792 )
2019
10
The added value of right ventricular longitudinal strain in patients with chronic thromboembolic pulmonary hypertension. ( 30421353 )
2019
11
Subcutaneous treprostinil for the treatment of severe non-operable chronic thromboembolic pulmonary hypertension (CTREPH): a double-blind, phase 3, randomised controlled trial. ( 30477763 )
2019
12
Subcutaneous treprostinil: a new treatment for chronic thromboembolic pulmonary hypertension? ( 30477764 )
2019
13
Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension. ( 30496427 )
2019
14
Efficacy and Safety of Bronchial Artery Embolization on Hemoptysis in Chronic Thromboembolic Pulmonary Hypertension: A Pilot Prospective Cohort Study. ( 30531186 )
2019
15
Three-Dimensional Echocardiographic Evaluation of Right Ventricular Function in Chronic Thromboembolic Pulmonary Hypertension: Finding Meaning in the "Forgotten". ( 30538062 )
2019
16
Prevalence of antiphospholipid (aPL) antibodies among patients with chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis. ( 30603858 )
2019
17
Multimodality treatment for chronic thromboembolic pulmonary hypertension. ( 30611397 )
2019
18
The ADAMTS13-VWF axis is dysregulated in chronic thromboembolic pulmonary hypertension. ( 30655285 )
2019
19
Switching from sildenafil to riociguat in patients with persistent or inoperable chronic thromboembolic pulmonary hypertension. ( 30661547 )
2019
20
Traditional screening tool in the era of modern treatment for chronic thromboembolic pulmonary hypertension. ( 30661845 )
2019
21
Autologous endothelial progenitor cell therapy improves right ventricular function in a model of chronic thromboembolic pulmonary hypertension. ( 30669226 )
2019
22
Chronic thromboembolic pulmonary hypertension versus fibrosing mediastinitis. ( 30694812 )
2019
23
Chronic thromboembolic pulmonary hypertension (CTEPH): what do we know about it? A comprehensive review of the literature. ( 30720636 )
2019
24
Working backward: Retrograde balloon angioplasty of atretic arteries in chronic thromboembolic pulmonary hypertension. ( 30723998 )
2019
25
Chronic Thromboembolic Pulmonary Hypertension Cases Cluster in Families. ( 30732691 )
2019
26
Pathophysiology of right ventricular failure in acute pulmonary embolism and chronic thromboembolic pulmonary hypertension: a pictorial essay for the interventional radiologist. ( 30758687 )
2019
27
Elevated levels of autoantibodies against EXD2 and PHAX in the sera of patients with chronic thromboembolic pulmonary hypertension. ( 30759165 )
2019
28
Molecular Research in Chronic Thromboembolic Pulmonary Hypertension. ( 30759794 )
2019
29
Shortening Hospital Stay Is Feasible and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension Treated With Balloon Pulmonary Angioplasty. ( 30760426 )
2019
30
Right Ventricular Load and Function in CTEPH: Differences between Proximal and Distal CTEPH. ( 30768356 )
2019
31
Successful Transition from Phosphodiesterase-5 Inhibitors to Riociguat Without a Washout Period in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Pilot Cohort Study. ( 30773322 )
2019
32
The predictors of complications in balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension. ( 30773792 )
2019
33
EXPRESS: Clinical characteristics and prognosis in patients with chronic thromboembolic pulmonary hypertension and a concomitant psychiatric disorder. ( 30777485 )
2019
34
Clinical usefulness of right ventricular 3D area strain in the assessment of treatment effects of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: comparison with 2D feature-tracking MRI. ( 30790024 )
2019
35
Commentary: Chronic thromboembolic pulmonary hypertension in Austria and Japan: The Sound of Music meets Madame Butterfly. ( 30798956 )
2019
36
Chronic Thromboembolic Pulmonary Hypertension: Endovascular Treatment. ( 30808072 )
2019
37
Balloon Pulmonary Angioplasty for the Treatment of Chronic Thromboembolic Pulmonary Hypertension. ( 30808613 )
2019
38
Everyday life experiences of spouses of patients who suffer from pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension. ( 30815471 )
2019
39
Meta-analysis of use of balloon pulmonary angioplasty in patients with inoperable chronic thromboembolic pulmonary hypertension. ( 30850238 )
2019
40
Role and management of extracorporeal life support after surgery of chronic thromboembolic pulmonary hypertension. ( 30854316 )
2019
41
Preoperative balloon pulmonary angioplasty enabled noncardiac surgery of a patient with chronic thromboembolic pulmonary hypertension (CTEPH): A case report. ( 30855499 )
2019
42
Long-term clinical value and outcome of riociguat in chronic thromboembolic pulmonary hypertension. ( 30859124 )
2019
43
Evaluation of a newly developed 2D parametric parenchymal blood flow technique with an automated vessel suppression algorithm in patients with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty. ( 30890260 )
2019
44
Commentary on: evaluation of a newly developed 2D parametric parenchymal blood flow technique with an automated vessel suppression algorithm in patients with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty. ( 30910170 )
2019
45
Risk Assessment in Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. ( 30923187 )
2019
46
Outcomes of Pulmonary Endarterectomy for Chronic Thromboembolic Pulmonary Hypertension at a Single Center in Taiwan. ( 30930563 )
2019
47
Pulmonary Artery Elastic Properties After Balloon Pulmonary Angioplasty in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 30935632 )
2019
48
Prevalence of antiphospholipid antibodies among patients with chronic thromboembolic pulmonary hypertension. ( 30937833 )
2019
49
EXPRESS: Circulating biomarkers in chronic thromboembolic pulmonary hypertension. ( 30942132 )
2019
50
Pulmonary endarterectomy in a toddler with chronic thromboembolic pulmonary hypertension after Denver shunt. ( 30952537 )
2019

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CPB2 CRP EDN1 FGA FGB NPPB
2 platelet alpha granule lumen GO:0031093 9.37 FGA FGB
3 extracellular vesicle GO:1903561 9.32 FGA FGB
4 platelet alpha granule GO:0031091 9.26 FGA FGB
5 extracellular space GO:0005615 9.17 BMPR2 CPB2 CRP EDN1 FGA FGB
6 fibrinogen complex GO:0005577 8.96 FGA FGB

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.81 CRP FGA FGB
2 blood coagulation GO:0007596 9.71 CPB2 FGA FGB
3 cell-matrix adhesion GO:0007160 9.64 FGA FGB
4 cellular response to interleukin-1 GO:0071347 9.63 EDN1 FGB
5 regulation of blood pressure GO:0008217 9.62 EDN1 NPPB
6 response to calcium ion GO:0051592 9.62 FGA FGB
7 positive regulation of endothelial cell migration GO:0010595 9.61 BMPR2 EDN1
8 platelet aggregation GO:0070527 9.61 FGA FGB
9 positive regulation of protein secretion GO:0050714 9.6 FGA FGB
10 toll-like receptor signaling pathway GO:0002224 9.59 FGA FGB
11 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 FGA FGB
12 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.58 FGA FGB
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.57 FGA FGB
14 positive regulation of vasoconstriction GO:0045907 9.56 FGA FGB
15 positive regulation of exocytosis GO:0045921 9.55 FGA FGB
16 cellular protein-containing complex assembly GO:0034622 9.52 FGA FGB
17 regulation of blood vessel size GO:0050880 9.51 EDN1 NPPB
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 FGA FGB
19 positive regulation of renal sodium excretion GO:0035815 9.48 EDN1 NPPB
20 positive regulation of urine volume GO:0035810 9.46 EDN1 NPPB
21 protein polymerization GO:0051258 9.43 FGA FGB
22 plasminogen activation GO:0031639 9.4 FGA FGB
23 body fluid secretion GO:0007589 9.37 EDN1 NPPB
24 positive regulation of peptide hormone secretion GO:0090277 9.32 FGA FGB
25 induction of bacterial agglutination GO:0043152 9.26 FGA FGB
26 blood coagulation, fibrin clot formation GO:0072378 9.16 FGA FGB
27 hemostasis GO:0007599 9.13 CPB2 FGA FGB
28 fibrinolysis GO:0042730 8.8 CPB2 FGA FGB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 8.96 FGA FGB
2 signaling receptor binding GO:0005102 8.92 EDN1 FGA FGB NPPB

Sources for Chronic Thromboembolic Pulmonary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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