CTEPH
MCID: CHR466
MIFTS: 43

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Categories: Blood diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

MalaCards integrated aliases for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 53 37 73
Cteph 53

Classifications:



External Ids:

KEGG 37 H01622
UMLS 73 C2363973

Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 53 Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. Signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). The disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). However, up to 60% of patients have no history of acute pulmonary embolism. Some people with this disease may have clotting problems. Research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific genemutations have been identified in CTEPH. Curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow). 

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to pulmonary hypertension and pulmonary embolism. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is NPPB (Natriuretic Peptide B), and among its related pathways/superpathways are Platelet Aggregation Inhibitor Pathway, Pharmacodynamics and Complement and coagulation cascades. The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 pulmonary hypertension 32.0 BMPR2 EDN1 NPPB
2 pulmonary embolism 30.9 CRP F2 NPPB
3 pulmonary hypertension, primary, 1 30.8 BMPR2 EDN1 FGA NPPB
4 eisenmenger syndrome 30.0 BMPR2 EDN1
5 dysfibrinogenemia 29.9 F2 FGA
6 sleep apnea 29.8 CRP EDN1 NPPB
7 arteries, anomalies of 29.5 BMPR2 CRP EDN1 NPPB
8 coronary artery anomaly 29.4 CRP EDN1 F2 NPPB
9 heart disease 29.1 BMPR2 CRP EDN1 F2 NPPB
10 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 12.1
11 thrombosis 10.4
12 antiphospholipid syndrome 10.3
13 sarcoma 10.2
14 ischemic heart disease 10.2 CRP NPPB
15 chronic mountain sickness 10.1 EDN1 NPPB
16 pericardial effusion 10.1 CRP NPPB
17 idiopathic edema 10.1 EDN1 NPPB
18 renal hypertension 10.1 EDN1 NPPB
19 pericarditis 10.1 CRP NPPB
20 heart valve disease 10.1 CRP NPPB
21 coronary stenosis 10.1 CRP NPPB
22 renal tuberculosis 10.1 CRP EDN1
23 apnea, obstructive sleep 10.1 CRP EDN1
24 aortic valve disease 2 10.1 CRP NPPB
25 oligohydramnios 10.1 EDN1 NPPB
26 chronic pulmonary heart disease 10.1 BMPR2 EDN1
27 collagen disease 10.1 CRP EDN1
28 sarcoidosis 1 10.1
29 thrombocytopenia 10.1
30 nephrotic syndrome 10.1
31 hepatopulmonary syndrome 10.0 BMPR2 EDN1
32 cardiac tamponade 10.0 F2 NPPB
33 malignant otitis externa 10.0 CRP F2
34 abdominal tuberculosis 10.0 CRP F2
35 ischemic neuropathy 10.0 CRP F2
36 blue toe syndrome 10.0 CRP F2
37 kawasaki disease 10.0 CRP NPPB
38 peripheral vertigo 10.0 CRP F2
39 endocardium disease 10.0 CRP F2
40 intracranial hypertension 10.0 F2 FGA
41 analbuminemia 10.0 CRP F2
42 systemic lupus erythematosus 10.0
43 lupus erythematosus 10.0
44 thrombophilia due to activated protein c resistance 10.0 F2 FGA
45 arteritic anterior ischemic optic neuropathy 10.0 CRP F2
46 systolic heart failure 10.0 CRP EDN1 NPPB
47 venous insufficiency 10.0 CRP F2
48 infective endocarditis 10.0 CRP F2
49 afibrinogenemia 10.0 F2 FGA
50 acute myocardial infarction 10.0 CRP EDN1 NPPB

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 BMPR2 CRP EDN1 F2 FGA
2 homeostasis/metabolism MP:0005376 9.1 BMPR2 CPB2 CRP EDN1 F2 FGA

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Adempas 18 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
2 Selexipag Approved Phase 3 475086-01-2
3
Treprostinil Approved, Investigational Phase 3 81846-19-7 54786 6918140
4
Ambrisentan Approved, Investigational Phase 3 177036-94-1 6918493
5 Antihypertensive Agents Phase 3,Phase 2
6 Endothelin Receptor Antagonists Phase 3,Phase 2
7 Calamus Phase 3
8
Macitentan Approved Phase 2 441798-33-0
9 Fluorodeoxyglucose F18 Phase 2
10 Radiopharmaceuticals Phase 2
11 Endothelin A Receptor Antagonists Phase 2
12 Vasodilator Agents Phase 2
13 Anti-Asthmatic Agents Phase 2
14 adrenomedullin Phase 2
15 Autonomic Agents Phase 2
16 Respiratory System Agents Phase 2
17 Cardiotonic Agents Phase 2
18 Bronchodilator Agents Phase 2
19 Protective Agents Phase 2
20 Peripheral Nervous System Agents Phase 2
21
Thrombin Approved, Investigational
22
Warfarin Approved 81-81-2 6691 54678486
23
Rivaroxaban Approved 366789-02-8
24
Tadalafil Approved, Investigational 171596-29-5 110635
25
Iloprost Approved, Investigational 78919-13-8 6443959
26
Serine Approved, Nutraceutical 56-45-1 5951
27 Tezosentan Investigational 180384-57-0
28 Anti-Infective Agents
29 Antiviral Agents
30 Deoxyglucose
31 Antimetabolites
32 Anticoagulants
33 Antibodies Not Applicable
34 Immunoglobulins Not Applicable
35 Autoantibodies Not Applicable
36 interferons Not Applicable
37 Coagulants
38 Hemostatics
39 Antithrombin III
40
protease inhibitors
41 Factor Xa Inhibitors
42 HIV Protease Inhibitors
43 Antithrombins
44 Serine Proteinase Inhibitors
45 Anesthetics Not Applicable
46 Sildenafil Citrate 171599-83-0
47 Phosphodiesterase 5 Inhibitors

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3 bosentan
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3 bosentan
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3 Riociguat (Adempas, BAY63-2521);Placebo
6 A Study to Find Out if Selexipag is Effective and Safe in Patients With Chronic Thromboembolic Pulmonary Hypertension When the Disease is Inoperable or Persistent/Recurrent After Surgery Recruiting NCT03689244 Phase 3 Selexipag;Placebo
7 A Clinical Study to Find Out if Macitentan is Effective and Safe in Japanese Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Recruiting NCT03809650 Phase 3 macitentan 10 mg
8 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
9 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3 Treprostinil sodium
10 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3 Riociguat (Adempas, BAY63-2521)
11 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3 Ambrisentan 5 mg;Placebo
12 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3 Ambrisentan 5 mg
13 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Unknown status NCT02745106 Phase 2
14 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2 Macitentan;Placebo
15 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
16 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
17 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2 Riociguat (Adempas, BAY63-2521)
18 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2 PulmoBind
19 Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Recruiting NCT03273257 Phase 2 Riociguat;Placebo
20 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2 Macitentan
21 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Active, not recruiting NCT02886793 Phase 1, Phase 2 fludeoxyglucose
22 This Study Tests the Safety of Inhaled BAY1237592, How the Drug is Tolerated and How it Effects Patients With High Blood Pressure in the Arteries of the Lungs in the Two Different Disease Groups Pulmonary Arterial Hypertension (PAH) and Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Not yet recruiting NCT03754660 Phase 1 BAY1237592;PH-monotherapy;PH-combination therapy
23 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Unknown status NCT02660463
24 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724 Not Applicable
25 Right Ventricular Resynchronization Therapy Unknown status NCT01163422 Not Applicable
26 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Unknown status NCT02964390 Not Applicable
27 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
28 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
29 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
30 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
31 Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) and Rubidium-82 (82Rb) Positron Emission Tomography/Computed Tomography (PET/CTs) on Pulmonary Arterial Hypertension (PAH) or Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Unknown status NCT02970851
32 Global Anticoagulant Registry in the FIELD- Venous Thromboembolic Events Unknown status NCT02155491
33 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
34 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465 Riociguat (Adempas, BAY63-2521)
35 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045 Not Applicable
36 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
37 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
38 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722 Not Applicable
39 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
40 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980 Not Applicable
41 Right Ventricular Pulmonary Vascular Interaction in Pulmonary Hypertension Completed NCT03523910 Not Applicable
42 EXPERT, EXPosurE Registry RiociguaT in Patients With Pulmonary Hypertension Completed NCT02092818 Riociguat (Adempas, BAY63-2521)
43 Auto-immunity and Pulmonary Arterial Hypertension Completed NCT01208792 Not Applicable
44 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203 Not Applicable Riociguat
45 Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region Recruiting NCT03349164
46 Dyspnea in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03786367
47 Pulmonary Endarterectomy Guided by CT Scanning for Patients With Chronic Thromboembolic Pulmonary Hypertension----PEACT Recruiting NCT03795740 Not Applicable
48 Taiwan Cohort - Chronic ThromboEmbolic Pulmonary Hypertension Registry Recruiting NCT03667391
49 Sleep-Disordered Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539 Not Applicable Riociguat
50 Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH) Recruiting NCT03719027 Not Applicable

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

41
Lung, Heart, Endothelial, Testes, Liver, Prostate, Kidney

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 932)
# Title Authors Year
1
Health-related quality of life, treatment adherence and psychosocial support in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension. ( 30011997 )
2019
2
Validation of a claims-based algorithm to identify patients with chronic thromboembolic pulmonary hypertension using electronic health record data. ( 30419792 )
2019
3
Balloon Pulmonary Angioplasty for Inoperable Patients With Chronic Thromboembolic Pulmonary Hypertension. Observational Study in a Referral Unit. ( 29857972 )
2018
4
Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. ( 29929993 )
2018
5
Impact of Balloon Pulmonary Angioplasty on Hemodynamics and Clinical Outcomes in Patients with Chronic Thromboembolic Pulmonary Hypertension: the Initial Korean Experience. ( 29318791 )
2018
6
Balloon Pulmonary Angioplasty Relieves Hemodynamic Stress towards Untreated-Side Pulmonary Vasculature and Ameliorates Its Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension. ( 29360065 )
2018
7
Neopterin as a Biomarker in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. ( 29909420 )
2018
8
Epidemiology and risk factors for chronic thromboembolic pulmonary hypertension. ( 29338883 )
2018
9
Use of direct oral anticoagulants for chronic thromboembolic pulmonary hypertension. ( 29791520 )
2018
10
Bosentan Therapy for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Systemic Review and Meta-Analysis. ( 29393580 )
2018
11
Severe Compression of the Left Main Coronary Artery in a Patient with Chronic Thromboembolic Pulmonary Hypertension. ( 29321385 )
2018
12
Poor Subpleural Perfusion Predicts Failure After Balloon Pulmonary Angioplasty for Nonoperable Chronic Thromboembolic Pulmonary Hypertension. ( 29730328 )
2018
13
MRI-derived Regional Biventricular Function in Patients with Chronic Thromboembolic Pulmonary Hypertension Before and After Pulmonary Endarterectomy. ( 29730148 )
2018
14
Usefulness of scoring right ventricular function for assessment of prognostic factors in patients with chronic thromboembolic pulmonary hypertension. ( 29704099 )
2018
15
Coping, social support and information in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A 2-year retrospective cohort study. ( 29326818 )
2018
16
Acute hemodynamic changes by breathing hypoxic and hyperoxic gas mixtures in pulmonary arterial and chronic thromboembolic pulmonary hypertension. ( 29891241 )
2018
17
Renin-angiotensin system regulates pulmonary arterial smooth muscle cell migration in chronic thromboembolic pulmonary hypertension. ( 29122755 )
2018
18
Chronic thromboembolic pulmonary hypertension: Reversal of pulmonary hypertension but not sleep disordered breathing following pulmonary endarterectomy. ( 29776563 )
2018
19
Incidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany. ( 29450722 )
2018
20
Plasma levels of high density lipoprotein cholesterol and outcomes in chronic thromboembolic pulmonary hypertension. ( 29813091 )
2018
21
Sequential treatment with riociguat and balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension. ( 29939102 )
2018
22
Early Introduction ofA Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients WithA Chronic Thromboembolic Pulmonary Hypertension. ( 29880110 )
2018
23
Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). ( 29846802 )
2018
24
Chronic thromboembolic pulmonary hypertension and homocysteinaemia. ( 29294117 )
2018
25
Klippel-Trenaunay-Weber syndrome as a cause of chronic thromboembolic pulmonary hypertension. ( 29572375 )
2018
26
Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. ( 29892707 )
2018
27
Prevalence of Coronary Artery to Pulmonary Artery Collaterals in Patients with Chronic Thromboembolic Pulmonary Hypertension: Retrospective Analysis from a Single Center. ( 27326914 )
2018
28
Comparative clinical and predictive value of lung perfusion blood volume CT, lung perfusion SPECT and catheter pulmonary angiography images in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty. ( 29802574 )
2018
29
Chronic Thromboembolic Pulmonary Hypertension. ( 29446688 )
2018
30
Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension-sampling plasma and surgical specimens. ( 29802084 )
2018
31
EXPRESS: Don't stop at first glance; pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension. ( 29873586 )
2018
32
Chronic Thromboembolic Pulmonary Hypertension. ( 29966632 )
2018
33
Chronic Thromboembolic Pulmonary Hypertension. ( 29872250 )
2018
34
Adherence and medication belief in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A nationwide population-based cohort survey. ( 29356440 )
2018
35
Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension. ( 29416329 )
2018
36
Curative resolution of chronic thromboembolic pulmonary hypertension with pulmonary thromboendarterectomy in primary antiphospholipid syndrome: A case report. ( 30290671 )
2018
37
Chronic Thromboembolic Pulmonary Hypertension and Antiphospholipid Syndrome with Immune Thrombocytopenia: A Case Report. ( 30337514 )
2018
38
Pulmonary thromboendarterectomy is a curative resolution for chronic thromboembolic pulmonary hypertension associated with antiphospholipid syndrome: a retrospective cohort study. ( 30451640 )
2018
39
Red Blood Cells Distribution Width as a Potential Prognostic Biomarker in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. ( 29107511 )
2018
40
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. ( 29157517 )
2018
41
Correlation between lung perfusion blood volume and SPECT images in patients with chronic thromboembolic pulmonary hypertension by balloon pulmonary angioplasty. ( 29161579 )
2018
42
Exercise facilitates early recognition of cardiac and vascular remodeling in chronic thromboembolic pulmonary hypertension in swine. ( 29167118 )
2018
43
DNA methylation signatures of pulmonary arterial smooth muscle cells in chronic thromboembolic pulmonary hypertension. ( 29473816 )
2018
44
Two-stage Treatment Using Balloon Pulmonary Angioplasty and Pulmonary Endarterectomy in a Patient with Chronic Thromboembolic Pulmonary Hypertension. ( 29481935 )
2018
45
Role of a clinical prediction score in a chronic thromboembolic pulmonary hypertension rule-out strategy. ( 29496752 )
2018
46
Detection and treatment of chronic thromboembolic pulmonary hypertension: Still a lot of homework to do. ( 29505828 )
2018
47
Prevention and treatment of the chronic thromboembolic pulmonary hypertension. ( 29526325 )
2018
48
A case of sarcoidosis-associated pulmonary hypertension masquerading as chronic thromboembolic pulmonary hypertension. ( 29537341 )
2018
49
Long-Term Outcome of Chronic Thromboembolic Pulmonary Hypertension at a Single Japanese Pulmonary Endarterectomy Center. ( 29540628 )
2018
50
Adiponectin in Chronic Thromboembolic Pulmonary Hypertension. ( 29563354 )
2018

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

Pathways related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 F2 FGA
2 10.94 CPB2 F2 FGA
3
Show member pathways
10.63 CRP EDN1
4 10.3 BMPR2 NPPB

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CPB2 CRP EDN1 F2 FGA NPPB
2 extracellular space GO:0005615 9.17 BMPR2 CPB2 CRP EDN1 F2 FGA

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.7 EDN1 F2 NPPB
2 cell surface receptor signaling pathway GO:0007166 9.63 EDN1 F2 NPPB
3 blood coagulation GO:0007596 9.61 CPB2 F2 FGA
4 regulation of blood pressure GO:0008217 9.51 EDN1 NPPB
5 positive regulation of endothelial cell migration GO:0010595 9.49 BMPR2 EDN1
6 acute-phase response GO:0006953 9.48 CRP F2
7 regulation of blood vessel size GO:0050880 9.4 EDN1 NPPB
8 positive regulation of renal sodium excretion GO:0035815 9.37 EDN1 NPPB
9 positive regulation of urine volume GO:0035810 9.32 EDN1 NPPB
10 negative regulation of fibrinolysis GO:0051918 9.26 CPB2 F2
11 body fluid secretion GO:0007589 9.16 EDN1 NPPB
12 hemostasis GO:0007599 9.13 CPB2 F2 FGA
13 fibrinolysis GO:0042730 8.8 CPB2 F2 FGA

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.92 EDN1 F2 FGA NPPB

Sources for Chronic Thromboembolic Pulmonary Hypertension

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