MCID: CHR466
MIFTS: 43

Chronic Thromboembolic Pulmonary Hypertension

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Chronic Thromboembolic Pulmonary Hypertension

MalaCards integrated aliases for Chronic Thromboembolic Pulmonary Hypertension:

Name: Chronic Thromboembolic Pulmonary Hypertension 53 37 73
Cteph 53

Classifications:



External Ids:

KEGG 37 H01622
UMLS 73 C2363973

Summaries for Chronic Thromboembolic Pulmonary Hypertension

NIH Rare Diseases : 53 Chronic thromboembolic pulmonary hypertension (CTEPH) is a unique pulmonary vascular disease caused by chronic block of the major lung arteries. Signs and symptoms commonly include progressive breathing difficulties (dyspnea) on exertion, fatigue, palpitations, loss of consciousness (syncope), or swelling (edema). The disease may appear a few months or many years after the sudden blockage in a lung artery by a blood clot (acute pulmonary embolism). However, up to 60% of patients have no history of acute pulmonary embolism. Some people with this disease may have clotting problems. Research suggests there may be a genetic predisposition leading to abnormal vascular healing after pulmonary embolism in susceptible individuals, but no specific genemutations have been identified in CTEPH. Curative treatment is done with pulmonary endarterectomy (a surgery that removes the blood clots in the lungs), and more recently by pulmonary balloon angioplasty (a procedure that opens up the vessels of the lung and increases blood flow). 

MalaCards based summary : Chronic Thromboembolic Pulmonary Hypertension, also known as cteph, is related to pulmonary hypertension and pulmonary embolism. An important gene associated with Chronic Thromboembolic Pulmonary Hypertension is FGA (Fibrinogen Alpha Chain), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Formation of Fibrin Clot (Clotting Cascade). The drugs Adempas and Bosentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and endothelial, and related phenotype is cardiovascular system.

Related Diseases for Chronic Thromboembolic Pulmonary Hypertension

Diseases related to Chronic Thromboembolic Pulmonary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 pulmonary hypertension 30.9 BMPR2 EDN1 NPPB
2 pulmonary embolism 30.2 CRP F2 NPPB
3 eisenmenger syndrome 29.6 BMPR2 EDN1
4 dysfibrinogenemia 29.5 F2 FGA FGB
5 coronary artery anomaly 28.2 CRP EDN1 FGA NPPB
6 arteries, anomalies of 27.8 CRP EDN1 F2 NPPB
7 heart disease 26.9 BMPR2 CRP EDN1 F2 NPPB
8 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 12.0
9 pulmonary hypertension, primary, 1 10.6
10 dysfibrinogenemia, congenital 10.4 FGA FGB
11 cardiogenic shock 10.4 CRP NPPB
12 systolic heart failure 10.3 CRP NPPB
13 thrombosis 10.3
14 pericardial effusion 10.3 CRP NPPB
15 pericarditis 10.2 CRP NPPB
16 cardiac tamponade 10.2 F2 NPPB
17 aortic valve disease 1 10.2 CRP NPPB
18 endotheliitis 10.2
19 thrombophilia due to activated protein c resistance 10.2 F2 FGA
20 malignant otitis externa 10.1 CRP F2
21 abdominal tuberculosis 10.1 CRP F2
22 ischemic neuropathy 10.1 CRP F2
23 blue toe syndrome 10.1 CRP F2
24 sarcoma 10.1
25 disseminated intravascular coagulation 10.1 F2 FGA
26 inherited blood coagulation disease 10.1 F2 FGB
27 peripheral vertigo 10.1 CRP F2
28 endocardium disease 10.1 CRP F2
29 analbuminemia 10.1 CRP F2
30 arteritic anterior ischemic optic neuropathy 10.1 CRP F2
31 hepatitis e 10.1 F2 FGB
32 antiphospholipid syndrome 10.0
33 infective endocarditis 10.0 CRP F2
34 venous insufficiency 10.0 CRP F2
35 intermittent claudication 10.0 CRP F2
36 leptospirosis 10.0 CRP F2
37 aortic valve disease 2 10.0 CRP NPPB
38 chronic mountain sickness 10.0 EDN1 NPPB
39 idiopathic edema 10.0 EDN1 NPPB
40 nutritional deficiency disease 10.0 CRP F2
41 renal hypertension 10.0 EDN1 NPPB
42 typhoid fever 10.0 CRP F2
43 depression 10.0
44 chronic pulmonary heart disease 9.9 BMPR2 EDN1
45 homocysteinemia 9.9 CRP F2
46 thrombocytosis 9.9 CRP F2
47 endocarditis 9.9 CRP F2
48 purpura 9.9 CRP F2
49 peritonitis 9.8 CRP F2
50 cholangitis 9.8 CRP F2

Graphical network of the top 20 diseases related to Chronic Thromboembolic Pulmonary Hypertension:



Diseases related to Chronic Thromboembolic Pulmonary Hypertension

Symptoms & Phenotypes for Chronic Thromboembolic Pulmonary Hypertension

MGI Mouse Phenotypes related to Chronic Thromboembolic Pulmonary Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.1 BMPR2 CRP EDN1 F2 FGA FGB

Drugs & Therapeutics for Chronic Thromboembolic Pulmonary Hypertension

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Adempas 18 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013

Drugs for Chronic Thromboembolic Pulmonary Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bosentan Approved, Investigational Phase 3 147536-97-8 104865
2
Treprostinil Approved, Investigational Phase 3 81846-19-7 54786 6918140
3 Endothelin Receptor Antagonists Phase 3,Phase 2
4 Antihypertensive Agents Phase 3,Phase 2
5 Calamus Nutraceutical Phase 3
6
Macitentan Approved Phase 2 441798-33-0
7 adrenomedullin Phase 2
8 Respiratory System Agents Phase 2
9 Fluorodeoxyglucose F18 Phase 2
10 Vasodilator Agents Phase 2
11 Anti-Asthmatic Agents Phase 2
12 Endothelin A Receptor Antagonists Phase 2
13 Peripheral Nervous System Agents Phase 2
14 Protective Agents Phase 2
15 Radiopharmaceuticals Phase 2
16 Autonomic Agents Phase 2
17 Bronchodilator Agents Phase 2
18
Warfarin Approved 81-81-2 6691 54678486
19
Rivaroxaban Approved 366789-02-8
20
Thrombin Approved, Investigational
21
Iloprost Approved, Investigational 78919-13-8 6443959
22
Tadalafil Approved, Investigational 171596-29-5 110635
23
Serine Approved, Nutraceutical 56-45-1 5951
24 Tezosentan Investigational 180384-57-0
25 Antibodies Not Applicable
26 Immunoglobulins Not Applicable
27 Autoantibodies Not Applicable
28 interferons Not Applicable
29
protease inhibitors
30 Serine Proteinase Inhibitors
31 Coagulants
32 Hemostatics
33 HIV Protease Inhibitors
34 Anesthetics Not Applicable
35 Deoxyglucose
36 Anticoagulants
37 Factor Xa Inhibitors
38 Anti-Infective Agents
39 Antimetabolites
40 Antiviral Agents
41 Antithrombin III
42 Antithrombins
43 Sildenafil Citrate 171599-83-0
44 Phosphodiesterase 5 Inhibitors

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Influence of Respiratory and Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA Unknown status NCT01393327 Phase 3
2 Bosentan Effects in Inoperable Forms of Chronic Thromboembolic Pulmonary Hypertension Completed NCT00313222 Phase 3 bosentan
3 Effect of Long-term Oxygen Therapy on Exercise Capacity and Quality of Life in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension Completed NCT01884012 Phase 3
4 Bosentan in Patients With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Completed NCT00319111 Phase 3 bosentan
5 A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH. Completed NCT00855465 Phase 3 Riociguat (Adempas, BAY63-2521);Placebo
6 CTEPH DIAGNOSIS Europe - MRI Recruiting NCT02791282 Phase 3
7 Efficacy and Tolerability of Subcutaneously Administered Treprostinil Sodium in Patients With Severe (Non-operable) Chronic Thromboembolic Pulmonary Hypertension (CTREPH) Active, not recruiting NCT01416636 Phase 3 Treprostinil sodium
8 BAY63-2521 - Long-term Extension Study in Patients With Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT00910429 Phase 3 Riociguat (Adempas, BAY63-2521)
9 Ambrisentan for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Terminated NCT01884675 Phase 3 Ambrisentan 5 mg;Placebo
10 A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Terminated NCT01894022 Phase 3 Ambrisentan 5 mg
11 Interventional Treatment of Residual Pulmonary Hypertension in Patients After Pulmonary Thromboendarterectomy Unknown status NCT02745106 Phase 2
12 Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Completed NCT02021292 Phase 2 Macitentan;Placebo
13 Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH Completed NCT02094001 Phase 2
14 Effect of Short-term Oxygen During CPET in Pulmonary Hypertension Completed NCT01748474 Phase 2
15 An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension Completed NCT00454558 Phase 2 Riociguat (Adempas, BAY63-2521)
16 Phase-II Study of the Use of PulmoBind for Molecular Imaging of Pulmonary Hypertension Completed NCT02216279 Phase 2 PulmoBind
17 Clinical Study to Assess the Safety, Tolerability and Efficacy of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension Active, not recruiting NCT02060721 Phase 2 Macitentan
18 Riociguat in Patients With Operable CTEPH Prior to Pulmonary Endarterectomy (PEA Bridging Study) Not yet recruiting NCT03273257 Phase 2 Riociguat;Placebo
19 Cell Proliferation in Pulmonary Hypertension. FDG-PET Comparison Between Patients and Healthy Subjects Not yet recruiting NCT02886793 Phase 1, Phase 2 fludeoxyglucose
20 Prospective Registry to Evaluate the Effective Incidence of Chronic Thromboembolic Pulmonary Hypertension in Germany Unknown status NCT02660463
21 Latent Pulmonary Hypertension (PH) in Chronic Thromboembolic Pulmonary Hypertension (CTEPH )After Endarterectomy and Influence of Exercise and Respiratory Therapy Unknown status NCT00477724 Not Applicable
22 Right Ventricular Resynchronization Therapy Unknown status NCT01163422 Not Applicable
23 3D Echocardiographic Assessment of RV Function in Patients Undergoing Pulmonary Endarterectomy Unknown status NCT02426203
24 Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Incidence in Patients With Central Versus Peripheral Embolism Unknown status NCT01672203
25 Epidemiological Study of Chronic Thromboembolic Pulmonary Hypertension in China Unknown status NCT01717092
26 Gene Mutations in Secondary Pulmonary Hypertension Unknown status NCT00348803
27 Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging Completed NCT02114047
28 A Study to Understand the Treatment Patterns in Patients With Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension During a Switch of Treatment to Adempas in Real-life Clinical Practice Completed NCT02545465 Riociguat (Adempas, BAY63-2521)
29 Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients Completed NCT00747045 Not Applicable
30 Study on the Clinical Course Of Pulmonary Embolism Completed NCT01781858
31 Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension Completed NCT02536534
32 Identification of Criteria of the Success of the Endarterectomy in Chronic Pulmonary Post Embolic Hypertension Completed NCT00657722 Not Applicable
33 Smoking: a Risk Factor for Pulmonary Arterial Hypertension? Completed NCT01484899
34 RF Surgical Sponge-Detecting System on the Function of Pacemakers and Implantable Cardioverter Defibrillators Completed NCT02111980 Not Applicable
35 Right Ventricular Pulmonary Vascular Interaction in Pulmonary Hypertension Completed NCT03523910 Not Applicable
36 Auto-immunity and Pulmonary Arterial Hypertension Completed NCT01208792 Not Applicable
37 Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension Recruiting NCT02634203 Not Applicable Riociguat
38 Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region Recruiting NCT03349164
39 Sleep Disorder Breathing in Chronic Thromboembolic Pulmonary Hypertension Recruiting NCT03074539 Not Applicable Riociguat
40 Identification of Heritable CTEPH Recruiting NCT03579862
41 Lung Perfusion Measured With Dual-Energy CT in Patients With Chronic Thromboembolic Pulmonary Hypertension: Comparative Study With Right Heart Catheterization and V/Q Recruiting NCT03450304
42 The Prospective Risk Factor Evaluation & Discovery In CTEPH Study Recruiting NCT03470207 Not Applicable
43 Determinants of Right Heart Remodeling in Patients With CTEPH or PAH Recruiting NCT03205085 Not Applicable
44 Assessment of Blood Coagulation Disorders in Patients With Pulmonary Hypertension Recruiting NCT03195543
45 Registry for Pulmonary Hypertension in China Recruiting NCT01417338
46 Long Term Outcomes of Venous Thromboembolism Recruiting NCT02268630
47 Balloon Pulmonary Angioplasty in Non-operable CTEPH Patients Recruiting NCT02964390 Not Applicable
48 Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH ) Recruiting NCT02117791 Riociguat (ADEMPAS, BAY63-2521)
49 International BPA Registry Recruiting NCT03245268
50 Early Non-invasive Detection of CTEPH After Pulmonary Embolism Recruiting NCT02555137

Search NIH Clinical Center for Chronic Thromboembolic Pulmonary Hypertension

Genetic Tests for Chronic Thromboembolic Pulmonary Hypertension

Anatomical Context for Chronic Thromboembolic Pulmonary Hypertension

MalaCards organs/tissues related to Chronic Thromboembolic Pulmonary Hypertension:

41
Lung, Heart, Endothelial, Testes, Brain, Smooth Muscle, Neutrophil

Publications for Chronic Thromboembolic Pulmonary Hypertension

Articles related to Chronic Thromboembolic Pulmonary Hypertension:

(show top 50) (show all 595)
# Title Authors Year
1
Balloon Pulmonary Angioplasty for Inoperable Patients With Chronic Thromboembolic Pulmonary Hypertension. Observational Study in a Referral Unit. ( 29857972 )
2018
2
Sequential Hybrid Therapy With Pulmonary Endarterectomy and Additional Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension. ( 29929993 )
2018
3
Impact of Balloon Pulmonary Angioplasty on Hemodynamics and Clinical Outcomes in Patients with Chronic Thromboembolic Pulmonary Hypertension: the Initial Korean Experience. ( 29318791 )
2018
4
Balloon Pulmonary Angioplasty Relieves Hemodynamic Stress towards Untreated-Side Pulmonary Vasculature and Ameliorates Its Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension. ( 29360065 )
2018
5
Neopterin as a Biomarker in Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension. ( 29909420 )
2018
6
Epidemiology and risk factors for chronic thromboembolic pulmonary hypertension. ( 29338883 )
2018
7
Use of direct oral anticoagulants for chronic thromboembolic pulmonary hypertension. ( 29791520 )
2018
8
Bosentan Therapy for Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension: A Systemic Review and Meta-Analysis. ( 29393580 )
2018
9
Severe Compression of the Left Main Coronary Artery in a Patient with Chronic Thromboembolic Pulmonary Hypertension. ( 29321385 )
2018
10
Poor Subpleural Perfusion Predicts Failure After Balloon Pulmonary Angioplasty for Nonoperable Chronic Thromboembolic Pulmonary Hypertension. ( 29730328 )
2018
11
MRI-derived Regional Biventricular Function in Patients with Chronic Thromboembolic Pulmonary Hypertension Before and After Pulmonary Endarterectomy. ( 29730148 )
2018
12
Usefulness of scoring right ventricular function for assessment of prognostic factors in patients with chronic thromboembolic pulmonary hypertension. ( 29704099 )
2018
13
Coping, social support and information in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A 2-year retrospective cohort study. ( 29326818 )
2018
14
Acute hemodynamic changes by breathing hypoxic and hyperoxic gas mixtures in pulmonary arterial and chronic thromboembolic pulmonary hypertension. ( 29891241 )
2018
15
Renin-angiotensin system regulates pulmonary arterial smooth muscle cell migration in chronic thromboembolic pulmonary hypertension. ( 29122755 )
2018
16
Chronic thromboembolic pulmonary hypertension: Reversal of pulmonary hypertension but not sleep disordered breathing following pulmonary endarterectomy. ( 29776563 )
2018
17
Incidence and characteristics of chronic thromboembolic pulmonary hypertension in Germany. ( 29450722 )
2018
18
Plasma levels of high density lipoprotein cholesterol and outcomes in chronic thromboembolic pulmonary hypertension. ( 29813091 )
2018
19
Sequential treatment with riociguat and balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension. ( 29939102 )
2018
20
Early Introduction ofA Pulmonary Endarterectomy or Balloon Pulmonary Angioplasty Contributes to Better Health-Related Quality of Life in Patients WithA Chronic Thromboembolic Pulmonary Hypertension. ( 29880110 )
2018
21
Dual-energy CT (DECT) lung perfusion in pulmonary hypertension: concordance rate with V/Q scintigraphy in diagnosing chronic thromboembolic pulmonary hypertension (CTEPH). ( 29846802 )
2018
22
Chronic thromboembolic pulmonary hypertension and homocysteinaemia. ( 29294117 )
2018
23
Klippel-Trenaunay-Weber syndrome as a cause of chronic thromboembolic pulmonary hypertension. ( 29572375 )
2018
24
Improvement in the electrocardiograms associated with right ventricular hypertrophy after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension. ( 29892707 )
2018
25
Prevalence of Coronary Artery to Pulmonary Artery Collaterals in Patients with Chronic Thromboembolic Pulmonary Hypertension: Retrospective Analysis from a Single Center. ( 27326914 )
2018
26
Comparative clinical and predictive value of lung perfusion blood volume CT, lung perfusion SPECT and catheter pulmonary angiography images in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty. ( 29802574 )
2018
27
Chronic Thromboembolic Pulmonary Hypertension. ( 29446688 )
2018
28
Usefulness of thrombosis and inflammation biomarkers in chronic thromboembolic pulmonary hypertension-sampling plasma and surgical specimens. ( 29802084 )
2018
29
EXPRESS: Don't stop at first glance; pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension. ( 29873586 )
2018
30
Chronic Thromboembolic Pulmonary Hypertension. ( 29966632 )
2018
31
Chronic Thromboembolic Pulmonary Hypertension. ( 29872250 )
2018
32
Adherence and medication belief in patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension: A nationwide population-based cohort survey. ( 29356440 )
2018
33
Sex-specific cardiopulmonary exercise testing indices to estimate the severity of inoperable chronic thromboembolic pulmonary hypertension. ( 29416329 )
2018
34
Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. ( 28750932 )
2017
35
The effective systematic heparin pre-treatment on thrombus formation on pulmonary artery catheter tips during pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: a randomized, double-blind study. ( 28875371 )
2017
36
Tidal Carbon Dioxide as a Prognostic Feature in Inoperable Chronic Thromboembolic Pulmonary Hypertension. ( 28806531 )
2017
37
Mosaic attenuation pattern in non-contrast computed tomography for the assessment of pulmonary perfusion in chronic thromboembolic pulmonary hypertension. ( 28942885 )
2017
38
Pulmonary Artery Diameter Predicts Lung Injury After Balloon Pulmonary Angioplasty in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28701673 )
2017
39
Depressive Status in Patients With Chronic Thromboembolic Pulmonary Hypertension. ( 28529263 )
2017
40
Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target. ( 28289017 )
2017
41
A Review of Clinical Trial Endpoints of Patients with Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension and How They Relate to Patient Outcomes in the United States. ( 28025931 )
2017
42
The changing landscape of chronic thromboembolic pulmonary hypertension management. ( 29263176 )
2017
43
Imaging in Chronic Thromboembolic Pulmonary Hypertension. ( 28060193 )
2017
44
Microarray Analysis and Detection of MicroRNAs Associated with Chronic Thromboembolic Pulmonary Hypertension. ( 28904974 )
2017
45
To screen or not to screen for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. ( 28073030 )
2017
46
Treatment Effect of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Quantified by Automatic Comparative Imaging in Computed Tomography Pulmonary Angiography. ( 29278545 )
2017
47
Riociguat for patients with chronic thromboembolic pulmonary hypertension: Usefulness of transitioning from phosphodiesterase type 5 inhibitor. ( 28705306 )
2017
48
Diagnostic accuracy of lung subtraction iodine mapping CT for the evaluation of pulmonary perfusion in patients with chronic thromboembolic pulmonary hypertension: Correlation with perfusion SPECT/CT. ( 28526539 )
2017
49
Epidemiology and management of chronic thromboembolic pulmonary hypertension: Experience from two expert centers. ( 28528258 )
2017
50
The Challenge in Diagnosis and Current Treatment of Chronic Thromboembolic Pulmonary Hypertension. ( 28790235 )
2017

Variations for Chronic Thromboembolic Pulmonary Hypertension

Expression for Chronic Thromboembolic Pulmonary Hypertension

Search GEO for disease gene expression data for Chronic Thromboembolic Pulmonary Hypertension.

Pathways for Chronic Thromboembolic Pulmonary Hypertension

Pathways related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 EDN1 F2 FGA FGB
2
Show member pathways
11.63 F2 FGA FGB
3 11.47 F2 FGA FGB
4 11.12 FGA FGB
5
Show member pathways
11.12 F2 FGA FGB
6
Show member pathways
10.88 CRP EDN1
7 10.66 BMPR2 NPPB
8 10.51 F2 FGA FGB

GO Terms for Chronic Thromboembolic Pulmonary Hypertension

Cellular components related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 CRP EDN1 F2 FGA FGB NPPB
2 external side of plasma membrane GO:0009897 9.54 F2 FGA FGB
3 blood microparticle GO:0072562 9.5 F2 FGA FGB
4 platelet alpha granule lumen GO:0031093 9.43 FGA FGB
5 extracellular vesicle GO:1903561 9.4 FGA FGB
6 platelet alpha granule GO:0031091 9.26 FGA FGB
7 extracellular space GO:0005615 9.17 BMPR2 CRP EDN1 F2 FGA FGB
8 fibrinogen complex GO:0005577 8.96 FGA FGB

Biological processes related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.82 EDN1 F2 NPPB
2 cell surface receptor signaling pathway GO:0007166 9.78 EDN1 F2 NPPB
3 blood coagulation GO:0007596 9.72 F2 FGA FGB
4 cellular response to interleukin-1 GO:0071347 9.65 EDN1 FGB
5 regulation of blood pressure GO:0008217 9.64 EDN1 NPPB
6 response to calcium ion GO:0051592 9.63 FGA FGB
7 positive regulation of endothelial cell migration GO:0010595 9.63 BMPR2 EDN1
8 toll-like receptor signaling pathway GO:0002224 9.62 FGA FGB
9 platelet aggregation GO:0070527 9.62 FGA FGB
10 positive regulation of protein secretion GO:0050714 9.61 FGA FGB
11 acute-phase response GO:0006953 9.6 CRP F2
12 negative regulation of endothelial cell apoptotic process GO:2000352 9.59 FGA FGB
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 FGA FGB
14 positive regulation of vasoconstriction GO:0045907 9.58 FGA FGB
15 platelet activation GO:0030168 9.58 F2 FGA FGB
16 positive regulation of substrate adhesion-dependent cell spreading GO:1900026 9.57 FGA FGB
17 positive regulation of exocytosis GO:0045921 9.56 FGA FGB
18 cellular protein-containing complex assembly GO:0034622 9.54 FGA FGB
19 regulation of blood vessel size GO:0050880 9.52 EDN1 NPPB
20 positive regulation of renal sodium excretion GO:0035815 9.51 EDN1 NPPB
21 positive regulation of urine volume GO:0035810 9.49 EDN1 NPPB
22 plasminogen activation GO:0031639 9.48 FGA FGB
23 protein polymerization GO:0051258 9.46 FGA FGB
24 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.43 FGA FGB
25 positive regulation of peptide hormone secretion GO:0090277 9.37 FGA FGB
26 body fluid secretion GO:0007589 9.32 EDN1 NPPB
27 induction of bacterial agglutination GO:0043152 9.26 FGA FGB
28 blood coagulation, fibrin clot formation GO:0072378 9.16 FGA FGB
29 hemostasis GO:0007599 9.13 F2 FGA FGB
30 fibrinolysis GO:0042730 8.8 F2 FGA FGB

Molecular functions related to Chronic Thromboembolic Pulmonary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.02 EDN1 F2 FGA FGB NPPB
2 cell adhesion molecule binding GO:0050839 8.96 FGA FGB

Sources for Chronic Thromboembolic Pulmonary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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