Aliases & Classifications for Chronic Tic Disorder

MalaCards integrated aliases for Chronic Tic Disorder:

Name: Chronic Tic Disorder 12 15
Chronic Motor or Vocal Tic Disorder 12 73
Tic Disorders 44
Tic Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10600
ICD10 33 F95.1 F95 F95.9
ICD9CM 35 307.22
MeSH 44 D013981
NCIt 50 C116768
SNOMED-CT 68 192623005
UMLS 73 C0008701

Summaries for Chronic Tic Disorder

Disease Ontology : 12 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

MalaCards based summary : Chronic Tic Disorder, also known as chronic motor or vocal tic disorder, is related to tic disorder and cytokine deficiency, and has symptoms including symptoms and recurrent muscle twitches (symptom). An important gene associated with Chronic Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Regulation of IFNA signaling and Immune response Fc epsilon RI pathway. The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and b cells, and related phenotype is homeostasis/metabolism.

Related Diseases for Chronic Tic Disorder

Diseases related to Chronic Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 tic disorder 31.3 DRD4 OFCC1
2 cytokine deficiency 10.4 IL13 IL5
3 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL13 IL5
4 respiratory syncytial virus infectious disease 10.4 IL13 IL5
5 gilles de la tourette syndrome 10.4
6 paragonimiasis 10.4 IL13 IL5
7 strongyloidiasis 10.3 IL13 IL5
8 ascaris lumbricoides infection 10.3 IL13 IL5
9 seborrheic infantile dermatitis 10.3 CSF2 IL5
10 obsessive-compulsive disorder 10.3
11 penicillin allergy 10.2 IL13 IL4
12 esophagitis, eosinophilic, 1 10.2 IL13 IL5
13 eosinophilic gastroenteritis 10.1 CSF2 IL5
14 cough variant asthma 10.1 IL4 IL5
15 pollen allergy 10.1 IL13 IL5
16 egg allergy 10.1 IL4 IL5
17 beta-lactam allergy 10.1 IL13 IL4
18 scleritis 10.1 IL4 IL5
19 intrinsic asthma 10.1 IL4 IL5
20 attention deficit-hyperactivity disorder 10.1
21 atopic keratoconjunctivitis 10.1 IL4 IL5
22 trichinosis 10.1 IL4 IL5
23 night blindness, congenital stationary, type 1a 10.0 IL13 IL5
24 gastrointestinal allergy 10.0 IL4 IL5
25 kimura disease 10.0 IL4 IL5
26 folliculitis 10.0 IL4 IL5
27 toxic oil syndrome 10.0 IL4 IL5
28 primary amebic meningoencephalitis 9.9 IL4 IL5
29 separation anxiety disorder 9.9 DRD4 HTR7
30 eosinophilic pneumonia 9.8 CSF2 IL13 IL5
31 esophageal disease 9.8 IL13 IL5
32 non-suppurative otitis media 9.8 CTSB IL4 IL5
33 aging 9.8
34 anxiety 9.8
35 trichotillomania 9.8
36 cercarial dermatitis 9.8 CTSB IL4 IL5
37 inflammatory bowel disease 4 9.8 IL13 IL4 IL5
38 angiostrongyliasis 9.8 IL13 IL4 IL5
39 apple allergy 9.8 IL13 IL4 IL5
40 latex allergy 9.7 IL13 IL4 IL5
41 eosinophilic meningitis 9.7 IL13 IL4 IL5
42 intestinal schistosomiasis 9.7 IL13 IL4 IL5
43 urinary schistosomiasis 9.7 IL13 IL4 IL5
44 chronic conjunctivitis 9.7 IL13 IL4 IL5
45 allergic bronchopulmonary aspergillosis 9.7 IL4 IL5
46 eosinophilic gastritis 9.7 IL13 IL4 IL5
47 vernal keratoconjunctivitis 9.7 IL13 IL4 IL5
48 conjunctival disease 9.7 IL13 IL4 IL5
49 enterobiasis 9.7 IL13 IL4 IL5
50 pulmonary eosinophilia 9.7 IL13 IL4 IL5

Graphical network of the top 20 diseases related to Chronic Tic Disorder:



Diseases related to Chronic Tic Disorder

Symptoms & Phenotypes for Chronic Tic Disorder

UMLS symptoms related to Chronic Tic Disorder:


symptoms, recurrent muscle twitches (symptom)

MGI Mouse Phenotypes related to Chronic Tic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.36 PICALM SLC1A1 CSF2 CTSB DRD4 F12

Drugs & Therapeutics for Chronic Tic Disorder

Drugs for Chronic Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 3,Not Applicable 129722-12-9 60795
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Guanfacine Approved, Investigational Phase 3 29110-47-2 3519
4
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
5 Neurotransmitter Agents Phase 3,Not Applicable
6 Antipsychotic Agents Phase 3,Not Applicable
7 Central Nervous System Depressants Phase 3,Not Applicable
8 Psychotropic Drugs Phase 3,Not Applicable
9 Tranquilizing Agents Phase 3,Not Applicable
10 Dopamine Agents Phase 3
11 Dopamine Antagonists Phase 3
12 Tiapride Hydrochloride Phase 3
13 Adrenergic Agents Phase 3
14 Adrenergic Agonists Phase 3
15 Adrenergic alpha-2 Receptor Agonists Phase 3
16 Adrenergic alpha-Agonists Phase 3
17 Antihypertensive Agents Phase 3
18
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
19 Anti-Infective Agents Phase 2,Not Applicable
20 Antidotes Phase 2
21 Antioxidants Phase 2
22 Antiviral Agents Phase 2
23 Expectorants Phase 2
24 N-monoacetylcystine Phase 2
25 Protective Agents Phase 2
26 Respiratory System Agents Phase 2
27
Acetylcholine Approved Not Applicable 51-84-3 187
28
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
29
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
30
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
31
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
32
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
33
Cycloserine Approved Not Applicable 68-41-7 401 6234
34
Menthol Approved Not Applicable 2216-51-5 16666
35 tannic acid Approved, Nutraceutical Not Applicable
36 abobotulinumtoxinA Not Applicable
37 Botulinum Toxins Not Applicable
38 Botulinum Toxins, Type A Not Applicable
39 Cholinergic Agents Not Applicable
40 Neuromuscular Agents Not Applicable
41 onabotulinumtoxinA Not Applicable
42 Peripheral Nervous System Agents Not Applicable
43 Amoxicillin-Potassium Clavulanate Combination Not Applicable
44 Anti-Bacterial Agents Not Applicable
45 Antibiotics, Antitubercular Not Applicable
46 beta-Lactamase Inhibitors Not Applicable
47 Clavulanic Acid Not Applicable
48 Antifungal Agents Not Applicable
49 Dermatologic Agents Not Applicable
50 Keratolytic Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
2 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
3 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
5 CANNAbinoids in the Treatment of TICS (CANNA-TICS) Recruiting NCT03087201 Phase 3 nabiximols;placebo
6 Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder Completed NCT00231985 Phase 2
7 VoIP Delivered Behavior Therapy for Tourette Syndrome Completed NCT02247206 Phase 2
8 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
9 Developing Cognitive Training for Tourette Syndrome Completed NCT01440023 Phase 1
10 Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome Unknown status NCT02187679 Not Applicable Abobotulinum toxin A
11 Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus Unknown status NCT01860300 Not Applicable Amoxicillin-Potassium Clavulanate Combination;placebo
12 Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Completed NCT00081419
13 Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Completed NCT02864589 Not Applicable
14 A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders Completed NCT02676492
15 Brain Activation in Vocal and Motor Tics Completed NCT00026000
16 Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders Completed NCT00675675 Not Applicable
17 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551 Not Applicable
18 TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) Completed NCT02413216 Not Applicable
19 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Recruiting NCT02067819 Not Applicable
20 Assessment of Children With Tic Onset in the Past 6 Months Recruiting NCT01177774
21 Neurofeedback for Tourette Syndrome Recruiting NCT01702077 Not Applicable
22 Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders Recruiting NCT02605902 Not Applicable
23 Modified Comprehensive Behavioral Intervention for Tics (M_CBIT) Recruiting NCT02900144 Not Applicable
24 Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo Active, not recruiting NCT02582515 Not Applicable D-cycloserine;Placebo
25 Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study Active, not recruiting NCT02114905 Not Applicable
26 Psychosocial Intervention for Young Children With Chronic Tics Active, not recruiting NCT03042507 Not Applicable
27 Aripiprazole in the Treatment of Tourette's Syndrome Terminated NCT00282139 Not Applicable Aripiprazole

Search NIH Clinical Center for Chronic Tic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: tic disorders

Genetic Tests for Chronic Tic Disorder

Anatomical Context for Chronic Tic Disorder

MalaCards organs/tissues related to Chronic Tic Disorder:

41
Brain, Colon, B Cells, Skin

Publications for Chronic Tic Disorder

Articles related to Chronic Tic Disorder:

(show all 42)
# Title Authors Year
1
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
2
Chronic tic disorders in children with ADHD. ( 29317441 )
2018
3
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
4
Tourette Syndrome and Chronic Tic Disorders: The Clinical Spectrum Beyond Tics. ( 28805580 )
2017
5
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
6
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
7
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
8
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
9
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
10
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
11
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
12
Relationships between Premonitory Urge and Anxiety in Youth with Chronic Tic Disorders. ( 27110050 )
2015
13
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
14
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
15
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
16
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
17
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
18
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
19
Evidence-based assessment of compulsive skin picking, chronic tic disorders and trichotillomania in children. ( 22488574 )
2012
20
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
21
Evidence-based pharmacotherapy for pediatric obsessive-compulsive disorder and chronic tic disorders. ( 23861643 )
2011
22
A proper name for chronic tic disorder. ( 20889671 )
2010
23
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. ( 19864199 )
2009
24
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. ( 19698938 )
2009
25
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. ( 18439116 )
2008
26
Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. ( 18058387 )
2008
27
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. ( 17717739 )
2008
28
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. ( 17345600 )
2008
29
Quality of life in youth with Tourette's syndrome and chronic tic disorder. ( 17484694 )
2007
30
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. ( 17171537 )
2007
31
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. ( 17453897 )
2007
32
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. ( 17052389 )
2006
33
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. ( 16536367 )
2006
34
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. ( 15368493 )
2004
35
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. ( 15248548 )
2004
36
A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. ( 12090818 )
2002
37
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. ( 11694329 )
2001
38
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. ( 11303888 )
2001
39
Associated psychopathology in children with both ADHD and chronic tic disorder. ( 8973069 )
1996
40
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. ( 8973076 )
1996
41
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. ( 8038934 )
1994
42
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. ( 8227493 )
1993

Variations for Chronic Tic Disorder

Expression for Chronic Tic Disorder

Search GEO for disease gene expression data for Chronic Tic Disorder.

Pathways for Chronic Tic Disorder

Pathways related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.39 CSF2 IL13 IL4 IL5
2
Show member pathways
12.36 CSF2 IL13 IL4 IL5
3
Show member pathways
12.07 CSF2 IL13 IL4 IL5
4 11.78 CSF2 IL4 IL5
5 11.67 CSF2 IL4 IL5
6 11.56 IL13 IL4 IL5
7
Show member pathways
11.51 CSF2 IL4 IL5
8 11.37 CSF2 IL13 IL4 IL5
9 11.27 CSF2 IL13 IL4
10 11.21 IL13 IL4 IL5
11 11.07 IL4 IL5
12 11.06 CSF2 IL13 IL4 IL5
13 11 IL13 IL4 IL5
14 10.85 IL13 IL4 IL5
15 10.4 CSF2 IL13 IL4 IL5

GO Terms for Chronic Tic Disorder

Biological processes related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CSF2 IL13 IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.71 CSF2 IL13 IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 9.62 CSF2 IL13 IL4 IL5
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 IL13 IL4
5 B cell activation GO:0042113 9.46 AKAP17A IL4
6 myeloid dendritic cell differentiation GO:0043011 9.37 CSF2 IL4
7 dendritic cell differentiation GO:0097028 9.26 CSF2 IL4
8 positive regulation of podosome assembly GO:0071803 9.16 CSF2 IL5
9 positive regulation of B cell proliferation GO:0030890 9.13 IL13 IL4 IL5
10 negative regulation of complement-dependent cytotoxicity GO:1903660 8.62 IL13 IL4

Molecular functions related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 AKAP17A CSF2 CTSB DNAJC13 DRD4 F12
2 growth factor activity GO:0008083 9.33 CSF2 IL4 IL5
3 cytokine receptor binding GO:0005126 9.26 IL13 IL4
4 cytokine activity GO:0005125 8.92 CSF2 IL13 IL4 IL5

Sources for Chronic Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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