Aliases & Classifications for Chronic Tic Disorder

MalaCards integrated aliases for Chronic Tic Disorder:

Name: Chronic Tic Disorder 12 15
Chronic Motor or Vocal Tic Disorder 12 73
Tic Disorders 44
Tic Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10600
ICD10 33 F95.1 F95 F95.9
ICD9CM 35 307.22
MeSH 44 D013981
NCIt 50 C116768

Summaries for Chronic Tic Disorder

Disease Ontology : 12 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

MalaCards based summary : Chronic Tic Disorder, also known as chronic motor or vocal tic disorder, is related to tic disorder and transient tic disorder, and has symptoms including symptoms and recurrent muscle twitches (symptom). An important gene associated with Chronic Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and JAK-STAT signaling pathway (KEGG). The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, b cells and lung, and related phenotype is homeostasis/metabolism.

Related Diseases for Chronic Tic Disorder

Diseases in the Tic Disorder family:

Chronic Tic Disorder Transient Tic Disorder

Diseases related to Chronic Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 tic disorder 31.3 OFCC1 DRD4
2 transient tic disorder 12.6
3 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 11.3
4 pediatric acute-onset neuropsychiatric syndrome 11.0
5 gilles de la tourette syndrome 10.6
6 obsessive-compulsive disorder 10.4
7 attention deficit-hyperactivity disorder 10.2
8 cytokine deficiency 10.1 IL5 IL13
9 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL5 IL13
10 respiratory syncytial virus infectious disease 10.1 IL5 IL13
11 paragonimiasis 10.1 IL5 IL13
12 separation anxiety disorder 10.1 HTR7 DRD4
13 strongyloidiasis 10.1 IL5 IL13
14 ascaris lumbricoides infection 10.1 IL5 IL13
15 seborrheic infantile dermatitis 10.1 IL5 CSF2
16 pollen allergy 10.1 IL5 IL13
17 schizophrenia 10.1
18 esophagitis, eosinophilic, 1 10.1 IL5 IL13
19 penicillin allergy 10.0 IL4 IL13
20 cough variant asthma 10.0 IL5 IL4
21 egg allergy 10.0 IL5 IL4
22 beta-lactam allergy 10.0 IL4 IL13
23 scleritis 10.0 IL5 IL4
24 atopic keratoconjunctivitis 10.0 IL5 IL4
25 sulfamethoxazole allergy 10.0 IL5 IL4
26 trichinosis 10.0 IL5 IL4
27 intrinsic asthma 10.0 IL5 IL4
28 gaucher disease, type ii 10.0 IL5 IL4
29 non-suppurative otitis media 10.0 IL5 IL4
30 filarial elephantiasis 10.0 IL5 IL4
31 kimura disease 10.0 IL5 IL4
32 mycoplasma pneumoniae pneumonia 10.0 IL4 IL13
33 toxic oil syndrome 10.0 IL5 IL4
34 night blindness, congenital stationary, type 1a 10.0 IL5 IL13
35 folliculitis 10.0 IL5 IL4
36 hypersplenism 10.0 IL4 CSF2
37 autism 10.0
38 autism spectrum disorder 10.0
39 encephalopathy 10.0
40 milk allergy 10.0 IL5 IL4
41 eosinophilic pneumonia 9.9 IL5 IL13 CSF2
42 allergic bronchopulmonary aspergillosis 9.9 IL5 IL4
43 stevens-johnson syndrome/toxic epidermal necrolysis 9.9 IL5 IL13
44 nickel allergic contact dermatitis 9.9 IL5 IL4 IL13
45 dermatitis 9.9 IL5 IL4 IL13
46 angiostrongyliasis 9.9 IL5 IL4 IL13
47 apple allergy 9.9 IL5 IL4 IL13
48 inflammatory bowel disease 4 9.9 IL5 IL4 IL13
49 eosinophilic meningitis 9.9 IL5 IL4 IL13
50 latex allergy 9.9 IL5 IL4 IL13

Graphical network of the top 20 diseases related to Chronic Tic Disorder:



Diseases related to Chronic Tic Disorder

Symptoms & Phenotypes for Chronic Tic Disorder

UMLS symptoms related to Chronic Tic Disorder:


symptoms, recurrent muscle twitches (symptom)

MGI Mouse Phenotypes related to Chronic Tic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.32 CSF2 DRD4 F12 HTR7 IL13 IL4

Drugs & Therapeutics for Chronic Tic Disorder

Drugs for Chronic Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 3,Not Applicable 129722-12-9 60795
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Guanfacine Approved, Investigational Phase 3 29110-47-2 3519
4
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
5 Neurotransmitter Agents Phase 3,Not Applicable
6 Psychotropic Drugs Phase 3,Not Applicable
7 Tranquilizing Agents Phase 3,Not Applicable
8 Antipsychotic Agents Phase 3,Not Applicable
9 Central Nervous System Depressants Phase 3,Not Applicable
10 Tiapride Hydrochloride Phase 3
11 Dopamine Antagonists Phase 3
12 Dopamine Agents Phase 3
13 Antihypertensive Agents Phase 3
14 Adrenergic Agents Phase 3
15 Adrenergic alpha-Agonists Phase 3
16 Adrenergic alpha-2 Receptor Agonists Phase 3
17 Adrenergic Agonists Phase 3
18
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
19 Anti-Infective Agents Phase 2,Not Applicable
20 Protective Agents Phase 2
21 Antiviral Agents Phase 2
22 Free Radical Scavengers Phase 2
23 Antioxidants Phase 2
24 Expectorants Phase 2
25 Respiratory System Agents Phase 2
26 N-monoacetylcystine Phase 2
27 Antidotes Phase 2
28
Acetylcholine Approved Not Applicable 51-84-3 187
29
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
30
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337
31 tannic acid Approved Not Applicable
32
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
33
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
34
Sulfamethazine Approved, Investigational, Vet_approved Not Applicable 57-68-1 5327
35
Cycloserine Approved Not Applicable 68-41-7 6234 401
36 onabotulinumtoxinA Not Applicable
37 Botulinum Toxins Not Applicable
38 Botulinum Toxins, Type A Not Applicable
39 Neuromuscular Agents Not Applicable
40 Cholinergic Agents Not Applicable
41 Peripheral Nervous System Agents Not Applicable
42 abobotulinumtoxinA Not Applicable
43 Acetylcholine Release Inhibitors Not Applicable
44 Anti-Bacterial Agents Not Applicable
45 Clavulanic Acids Not Applicable
46 Antibiotics, Antitubercular Not Applicable
47 beta-Lactamase Inhibitors Not Applicable
48 Amoxicillin-Potassium Clavulanate Combination Not Applicable
49 Dermatologic Agents Not Applicable
50 Keratolytic Agents Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
2 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
3 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
5 CANNAbinoids in the Treatment of TICS (CANNA-TICS) Recruiting NCT03087201 Phase 3 nabiximols;placebo
6 Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder Completed NCT00231985 Phase 2
7 VoIP Delivered Behavior Therapy for Tourette Syndrome Completed NCT02247206 Phase 2
8 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
9 Developing Cognitive Training for Tourette Syndrome Completed NCT01440023 Phase 1
10 Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome Unknown status NCT02187679 Not Applicable Abobotulinum toxin A
11 Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus Unknown status NCT01860300 Not Applicable Amoxicillin-Potassium Clavulanate Combination;placebo
12 Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Completed NCT00081419
13 Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Completed NCT02864589 Not Applicable
14 A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders Completed NCT02676492
15 Neurofeedback for Tourette Syndrome Completed NCT01702077 Not Applicable
16 Brain Activation in Vocal and Motor Tics Completed NCT00026000
17 Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders Completed NCT00675675 Not Applicable
18 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551 Not Applicable
19 TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) Completed NCT02413216 Not Applicable
20 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Recruiting NCT02067819 Not Applicable
21 Assessment of Children With Tic Onset in the Past 6 Months Recruiting NCT01177774
22 Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders Recruiting NCT02605902 Not Applicable
23 Modified Comprehensive Behavioral Intervention for Tics (M_CBIT) Recruiting NCT02900144 Not Applicable
24 Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo Active, not recruiting NCT02582515 Not Applicable D-cycloserine;Placebo
25 Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study Active, not recruiting NCT02114905 Not Applicable
26 Psychosocial Intervention for Young Children With Chronic Tics Active, not recruiting NCT03042507 Not Applicable
27 Aripiprazole in the Treatment of Tourette's Syndrome Terminated NCT00282139 Not Applicable Aripiprazole

Search NIH Clinical Center for Chronic Tic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: tic disorders

Genetic Tests for Chronic Tic Disorder

Anatomical Context for Chronic Tic Disorder

MalaCards organs/tissues related to Chronic Tic Disorder:

41
Brain, B Cells, Lung, Skin, Thyroid, T Cells

Publications for Chronic Tic Disorder

Articles related to Chronic Tic Disorder:

(show all 37)
# Title Authors Year
1
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
2
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
3
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
4
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
5
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
6
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
7
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
8
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
9
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
10
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
11
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
12
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
13
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
14
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
15
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
16
A proper name for chronic tic disorder. ( 20889671 )
2010
17
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. ( 19864199 )
2009
18
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. ( 19698938 )
2009
19
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. ( 18439116 )
2008
20
Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. ( 18058387 )
2008
21
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. ( 17717739 )
2008
22
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. ( 17345600 )
2008
23
Quality of life in youth with Tourette's syndrome and chronic tic disorder. ( 17484694 )
2007
24
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. ( 17171537 )
2007
25
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. ( 17453897 )
2007
26
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. ( 17052389 )
2006
27
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. ( 16536367 )
2006
28
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. ( 15368493 )
2004
29
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. ( 15248548 )
2004
30
A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. ( 12090818 )
2002
31
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. ( 11694329 )
2001
32
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. ( 11303888 )
2001
33
Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. ( 10433130 )
1999
34
Associated psychopathology in children with both ADHD and chronic tic disorder. ( 8973069 )
1996
35
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. ( 8973076 )
1996
36
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. ( 8038934 )
1994
37
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. ( 8227493 )
1993

Variations for Chronic Tic Disorder

Expression for Chronic Tic Disorder

Search GEO for disease gene expression data for Chronic Tic Disorder.

Pathways for Chronic Tic Disorder

Pathways related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.38 CSF2 IL13 IL4 IL5
2
Show member pathways
12.19 CSF2 IL13 IL4 IL5
3
Show member pathways
12.09 CSF2 IL13 IL4 IL5
4
Show member pathways
11.84 CSF2 IL13 IL4
5 11.8 CSF2 IL4 IL5
6 11.7 CSF2 IL4 IL5
7 11.59 IL13 IL4 IL5
8
Show member pathways
11.55 CSF2 IL4 IL5
9 11.5 CSF2 IL13 IL4
10 11.37 CSF2 IL13 IL4 IL5
11 11.3 CSF2 IL13 IL4
12 11.21 IL13 IL4 IL5
13 11.09 IL4 IL5
14 11.06 CSF2 IL13 IL4 IL5
15 11 IL13 IL4 IL5
16 10.94 CSF2 IL13 IL4 IL5
17 10.85 IL13 IL4 IL5
18 10.79 CSF2 IL13 IL4 IL5
19 10.39 CSF2 IL13 IL4 IL5

GO Terms for Chronic Tic Disorder

Biological processes related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.76 CSF2 IL13 IL4 IL5
2 regulation of signaling receptor activity GO:0010469 9.73 CSF2 IL13 IL4 IL5
3 cytokine-mediated signaling pathway GO:0019221 9.56 CSF2 IL13 IL4 IL5
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.51 IL13 IL4
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.49 DRD4 HTR7
6 B cell activation GO:0042113 9.48 AKAP17A IL4
7 myeloid dendritic cell differentiation GO:0043011 9.4 CSF2 IL4
8 dendritic cell differentiation GO:0097028 9.37 CSF2 IL4
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 CSF2 IL13 IL4
10 positive regulation of podosome assembly GO:0071803 9.32 CSF2 IL5
11 negative regulation of complement-dependent cytotoxicity GO:1903660 8.96 IL13 IL4
12 positive regulation of B cell proliferation GO:0030890 8.8 IL13 IL4 IL5

Molecular functions related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.73 AKAP17A CSF2 DNAJC13 DRD4 F12 IL13
2 neurotransmitter receptor activity GO:0030594 9.37 DRD4 HTR7
3 growth factor activity GO:0008083 9.33 CSF2 IL4 IL5
4 G protein-coupled serotonin receptor activity GO:0004993 9.32 DRD4 HTR7
5 cytokine receptor binding GO:0005126 9.26 IL13 IL4
6 cytokine activity GO:0005125 8.92 CSF2 IL13 IL4 IL5

Sources for Chronic Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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