Aliases & Classifications for Chronic Tic Disorder

MalaCards integrated aliases for Chronic Tic Disorder:

Name: Chronic Tic Disorder 12 15
Chronic Motor or Vocal Tic Disorder 12 74
Tic Disorders 45
Tic Disorder 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10600
ICD9CM 36 307.22
MeSH 45 D013981
NCIt 51 C116768
ICD10 34 F95 F95.1 F95.9

Summaries for Chronic Tic Disorder

Disease Ontology : 12 A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year.

MalaCards based summary : Chronic Tic Disorder, also known as chronic motor or vocal tic disorder, is related to gilles de la tourette syndrome and tic disorder, and has symptoms including symptoms and recurrent muscle twitches (symptom). An important gene associated with Chronic Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Dopamine and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include brain, colon and b cells, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Chronic Tic Disorder

Diseases in the Tic Disorder family:

Chronic Tic Disorder Transient Tic Disorder

Diseases related to Chronic Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 gilles de la tourette syndrome 31.1 DRD2 DRD4 DRD5
2 tic disorder 30.9 DRD2 DRD4 DRD5 OFCC1
3 obsessive-compulsive disorder 30.3 DRD1 DRD2 DRD3 DRD4 SLC1A1
4 early-onset schizophrenia 30.1 DRD1 DRD2
5 conduct disorder 30.0 DRD2 DRD4 DRD5
6 attention deficit-hyperactivity disorder 30.0 DRD1 DRD2 DRD3 DRD4 DRD5
7 disease of mental health 29.9 DRD2 DRD3 DRD4
8 schizophrenia 29.5 DRD1 DRD2 DRD3 DRD4 DRD5 SLC1A1
9 transient tic disorder 12.7
10 pediatric acute-onset neuropsychiatric syndrome 11.0
11 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 11.0
12 polysubstance abuse 10.2 DRD2 DRD3
13 pol iii-related leukodystrophies 10.2
14 tardive dyskinesia 10.2 DRD2 DRD3
15 eosinophilic fasciitis 10.2 AHR IL5
16 delusional disorder 10.1 DRD2 DRD3 DRD4
17 impulse control disorder 10.1 DRD2 DRD3 DRD4
18 migraine without aura 10.1 DRD2 DRD3 DRD4
19 cytokine deficiency 10.1 IL13 IL5
20 angioimmunoblastic lymphadenopathy with dysproteinemia 10.1 IL13 IL5
21 eosinophilia-myalgia syndrome 10.1 AHR IL5
22 mood disorder 10.1 DRD2 DRD3 DRD4
23 respiratory syncytial virus infectious disease 10.1 IL13 IL5
24 schizoaffective disorder 10.1 DRD2 DRD3 SLC1A1
25 bruxism 10.1 DRD2 DRD3 DRD5
26 heroin dependence 10.1 DRD2 DRD4
27 nickel allergic contact dermatitis 10.1 IL13 IL5
28 paragonimiasis 10.1 IL13 IL5
29 inflammatory bowel disease 4 10.1 IL13 IL5
30 angiostrongyliasis 10.1 IL13 IL5
31 exposure keratitis 10.0 DRD5 IL13
32 apple allergy 10.0 IL13 IL5
33 migraine with or without aura 1 10.0 DRD2 DRD3 DRD5
34 strongyloidiasis 10.0 IL13 IL5
35 ascaris lumbricoides infection 10.0 IL13 IL5
36 esophagitis, eosinophilic, 1 10.0 IL13 IL5
37 seborrheic infantile dermatitis 10.0 CSF2 IL5
38 latex allergy 10.0 IL13 IL5
39 eosinophilic meningitis 10.0 IL13 IL5
40 intestinal schistosomiasis 10.0 IL13 IL5
41 autism 10.0
42 autism spectrum disorder 10.0
43 encephalopathy 10.0
44 substance abuse 10.0 DRD2 DRD3 DRD4 DRD5
45 chronic conjunctivitis 10.0 IL13 IL5
46 substance dependence 10.0 DRD2 DRD3 DRD4 DRD5
47 pathological gambling 10.0 DRD1 DRD2 DRD3 DRD4
48 alcohol abuse 10.0 DRD1 DRD2 DRD3 DRD4
49 eosinophilic gastritis 9.9 IL13 IL5
50 alcohol dependence 9.9 DRD1 DRD2 DRD3 DRD4

Graphical network of the top 20 diseases related to Chronic Tic Disorder:



Diseases related to Chronic Tic Disorder

Symptoms & Phenotypes for Chronic Tic Disorder

UMLS symptoms related to Chronic Tic Disorder:


symptoms, recurrent muscle twitches (symptom)

MGI Mouse Phenotypes related to Chronic Tic Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 AHR CSF2 DRD1 DRD2 DRD3 DRD4
2 homeostasis/metabolism MP:0005376 10.03 AHR CSF2 DRD1 DRD2 DRD3 DRD4
3 nervous system MP:0003631 9.85 AHR CSF2 DRD1 DRD2 DRD3 DRD4
4 digestive/alimentary MP:0005381 9.8 AHR DRD1 DRD2 DRD3 IL13 IL5
5 renal/urinary system MP:0005367 9.43 AHR CSF2 DRD2 DRD3 DRD5 SLC1A1
6 respiratory system MP:0005388 9.1 AHR CSF2 DRD1 DRD2 IL13 IL5

Drugs & Therapeutics for Chronic Tic Disorder

Drugs for Chronic Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3,Not Applicable 62-31-7, 51-61-6 681
2
Aripiprazole Approved, Investigational Phase 3,Not Applicable 129722-12-9 60795
3
Guanfacine Approved, Investigational Phase 3 29110-47-2 3519
4
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
5 Nabiximols Investigational Phase 3 56575-23-6
6 Neurotransmitter Agents Phase 3,Not Applicable
7 Peripheral Nervous System Agents Phase 3,Not Applicable
8 Dopamine Agents Phase 3,Not Applicable
9 Central Nervous System Depressants Phase 3,Not Applicable
10 Antidepressive Agents Phase 3,Not Applicable
11 Dopamine agonists Phase 3,Not Applicable
12 Dopamine D2 Receptor Antagonists Phase 3,Not Applicable
13 Serotonin 5-HT1 Receptor Agonists Phase 3,Not Applicable
14 Serotonin Receptor Agonists Phase 3,Not Applicable
15 Psychotropic Drugs Phase 3,Not Applicable
16 Serotonin Agents Phase 3,Not Applicable
17 Serotonin Antagonists Phase 3,Not Applicable
18 Antipsychotic Agents Phase 3,Not Applicable
19 Serotonin 5-HT2 Receptor Antagonists Phase 3,Not Applicable
20 Dopamine Antagonists Phase 3,Not Applicable
21 Tranquilizing Agents Phase 3,Not Applicable
22 Tiapride Hydrochloride Phase 3
23 Adrenergic Agonists Phase 3
24 Adrenergic alpha-2 Receptor Agonists Phase 3
25 Adrenergic alpha-Agonists Phase 3
26 Adrenergic Agents Phase 3
27 Antihypertensive Agents Phase 3
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
29 Analgesics, Non-Narcotic Phase 3
30 Analgesics Phase 3
31 Epidiolex Phase 3
32 Hormone Antagonists Phase 3
33 Hallucinogens Phase 3
34 Hormones Phase 3
35 Cannabinoid Receptor Agonists Phase 3
36
Serotonin Investigational, Nutraceutical Phase 3,Not Applicable 50-67-9 5202
37
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
38 Anti-Infective Agents Phase 2,Not Applicable
39 Expectorants Phase 2
40 N-monoacetylcystine Phase 2
41 Antidotes Phase 2
42 Antiviral Agents Phase 2
43 Antioxidants Phase 2
44 Free Radical Scavengers Phase 2
45 Respiratory System Agents Phase 2
46 Protective Agents Phase 2
47
Acetylcholine Approved, Investigational Not Applicable 51-84-3 187
48
Clavulanate Approved, Vet_approved Not Applicable 58001-44-8 5280980
49
Amoxicillin Approved, Vet_approved Not Applicable 26787-78-0 33613
50
Benzocaine Approved, Investigational Not Applicable 94-09-7, 1994-09-7 2337

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Completed NCT00706589 Phase 3 aripiprazole;placebo
2 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
3 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo
4 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine for Tourette Syndrome and Attention Deficit Hyperactivity Disorder Completed NCT00004376 Phase 3 guanfacine
5 CANNAbinoids in the Treatment of TICS (CANNA-TICS) Recruiting NCT03087201 Phase 3 nabiximols;placebo
6 Effectiveness of Behavior Therapy and Psychosocial Therapy for the Treatment of Tourette Syndrome and Chronic Tic Disorder Completed NCT00231985 Phase 2
7 VoIP Delivered Behavior Therapy for Tourette Syndrome Completed NCT02247206 Phase 2
8 N-acetylcysteine (NAC) for Children With Tourette Syndrome Completed NCT01172288 Phase 2 N-Acetylcysteine (NAC);Placebo
9 Developing Cognitive Training for Tourette Syndrome Completed NCT01440023 Phase 1
10 Pilot Study for Use of Dysport in Treatment of Vocal Tics in Patients With Tourette's Syndrome Unknown status NCT02187679 Not Applicable Abobotulinum toxin A
11 Efficacy of Amoxicilline/Clavulanic Acid in Patients Affected by Tic Disorder Colonized by Group A Streptococcus Unknown status NCT01860300 Not Applicable Amoxicillin-Potassium Clavulanate Combination;placebo
12 Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Completed NCT00081419
13 Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder Completed NCT02864589 Not Applicable
14 A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders Completed NCT02676492
15 Neurofeedback for Tourette Syndrome Completed NCT01702077 Not Applicable
16 Brain Activation in Vocal and Motor Tics Completed NCT00026000
17 Neurocognitive Correlates of Behavioral Treatment for Childhood Tic Disorders Completed NCT00675675 Not Applicable
18 Anger Control Training for Youth With Tourette Syndrome Completed NCT00486551 Not Applicable
19 TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) Completed NCT02413216 Not Applicable
20 Proof of Concept Study of an Oral Orthotic to Reduce Tic Severity in Chronic Tic Disorder and Tourette Syndrome Recruiting NCT02067819 Not Applicable
21 Assessment of Children With Tic Onset in the Past 6 Months Recruiting NCT01177774
22 Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders Recruiting NCT02605902 Not Applicable
23 Modified Comprehensive Behavioral Intervention for Tics (M_CBIT) Recruiting NCT02900144 Not Applicable
24 Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo Active, not recruiting NCT02582515 Not Applicable D-cycloserine;Placebo
25 Dissemination of Comprehensive Behavioral Intervention for Tics (CBIT) to Occupational Therapists: A Feasibility Study Active, not recruiting NCT02114905 Not Applicable
26 Psychosocial Intervention for Young Children With Chronic Tics Active, not recruiting NCT03042507 Not Applicable
27 Aripiprazole in the Treatment of Tourette's Syndrome Terminated NCT00282139 Not Applicable Aripiprazole

Search NIH Clinical Center for Chronic Tic Disorder

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: tic disorders

Genetic Tests for Chronic Tic Disorder

Anatomical Context for Chronic Tic Disorder

MalaCards organs/tissues related to Chronic Tic Disorder:

42
Brain, Colon, B Cells

Publications for Chronic Tic Disorder

Articles related to Chronic Tic Disorder:

(show all 38)
# Title Authors Year
1
Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders. ( 30640363 )
2019
2
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
3
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
4
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
5
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
6
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
7
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
8
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
9
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
10
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
11
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
12
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
13
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
14
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
15
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
16
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
17
A proper name for chronic tic disorder. ( 20889671 )
2010
18
Short-term sulpiride treatment of children and adolescents with Tourette syndrome or chronic tic disorder. ( 19864199 )
2009
19
Cognitive behavioral management of Tourette's syndrome and chronic tic disorder in medicated and unmedicated samples. ( 19698938 )
2009
20
Aripiprazole treatment of children and adolescents with Tourette disorder or chronic tic disorder. ( 18439116 )
2008
21
Cognitive-behaviour therapy and skilled motor performance in adults with chronic tic disorder. ( 18058387 )
2008
22
Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder. ( 17717739 )
2008
23
Obsessive-compulsive disorder in youth with and without a chronic tic disorder. ( 17345600 )
2008
24
Quality of life in youth with Tourette's syndrome and chronic tic disorder. ( 17484694 )
2007
25
Psychopathological profile in children with chronic tic disorder and co-existing ADHD: additive effects. ( 17171537 )
2007
26
Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder. ( 17453897 )
2007
27
Association between the polymorphism in the promoter region of dopamine D4 receptor gene and chronic tic disorder. ( 17052389 )
2006
28
Attention deficit hyperactivity disorder, chronic tic disorder, and methylphenidate. ( 16536367 )
2006
29
Candidate locus for Gilles de la Tourette syndrome/obsessive compulsive disorder/chronic tic disorder at 18q22. ( 15368493 )
2004
30
A computer-aided diagnosis for distinguishing Tourette's syndrome from chronic tic disorder in children by a fuzzy system with a two-step minimization approach. ( 15248548 )
2004
31
A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. ( 12090818 )
2002
32
Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder. ( 11694329 )
2001
33
Differences in 99mTc-HMPAO brain SPET perfusion imaging between Tourette's syndrome and chronic tic disorder in children. ( 11303888 )
2001
34
Regional cerebral blood flow in obsessive-compulsive patients with and without a chronic tic disorder. A SPECT study. ( 10433130 )
1999
35
Associated psychopathology in children with both ADHD and chronic tic disorder. ( 8973069 )
1996
36
A putative poststreptococcal case of OCD with chronic tic disorder, not otherwise specified. ( 8973076 )
1996
37
Obsessive-compulsive disorder with and without a chronic tic disorder. A comparison of symptoms in 70 patients. ( 8038934 )
1994
38
The efficacy of fluvoxamine in obsessive-compulsive disorder: effects of comorbid chronic tic disorder. ( 8227493 )
1993

Variations for Chronic Tic Disorder

Expression for Chronic Tic Disorder

Search GEO for disease gene expression data for Chronic Tic Disorder.

Pathways for Chronic Tic Disorder

Pathways related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 DRD1 DRD2 DRD3 DRD4 DRD5 SLC1A1
2
Show member pathways
12.57 DRD1 DRD2 DRD3 DRD4 DRD5
3 12.01 DRD1 DRD2 DRD3 DRD4 DRD5
4
Show member pathways
11.93 DRD1 DRD2 DRD4 DRD5
6
Show member pathways
11.71 DRD2 DRD3 DRD4
7 11.6 CSF2 IL13 IL5
8 11.57 AHR IL13 IL5
9 11.43 CSF2 IL13 IL5
10
Show member pathways
11.4 DRD1 DRD2 DRD3 DRD4 DRD5
11 11.05 AHR IL13 IL5
12 10.96 CSF2 IL13 IL5
13 10.95 IL13 IL5
14 10.27 DRD1 DRD2 DRD3 DRD5

GO Terms for Chronic Tic Disorder

Cellular components related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.85 DRD1 DRD2 DRD3 DRD4 DRD5 SLC1A1
2 glutamatergic synapse GO:0098978 9.62 DRD1 DRD2 DRD3 DRD4
3 GABA-ergic synapse GO:0098982 9.33 DRD1 DRD2 DRD3
4 dopaminergic synapse GO:0098691 9.26 DRD2 DRD3
5 ciliary membrane GO:0060170 9.13 DRD1 DRD2 DRD5
6 non-motile cilium GO:0097730 8.8 DRD1 DRD2 DRD5

Biological processes related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.86 DRD2 DRD3 IL13
2 cellular calcium ion homeostasis GO:0006874 9.85 DRD3 DRD4 DRD5
3 locomotory behavior GO:0007626 9.85 DRD1 DRD2 DRD3
4 circadian regulation of gene expression GO:0032922 9.79 AHR DRD2 DRD3
5 visual learning GO:0008542 9.79 DRD1 DRD2 DRD3
6 response to cocaine GO:0042220 9.76 DRD1 DRD2 DRD3 DRD5
7 associative learning GO:0008306 9.74 DRD1 DRD2 DRD5
8 negative regulation of blood pressure GO:0045776 9.73 DRD2 DRD3 DRD5
9 arachidonic acid secretion GO:0050482 9.71 DRD2 DRD3 DRD4
10 temperature homeostasis GO:0001659 9.7 DRD1 DRD2
11 negative regulation of protein secretion GO:0050709 9.7 DRD2 DRD3 DRD4
12 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.69 DRD2 DRD3
13 transmission of nerve impulse GO:0019226 9.69 DRD1 DRD5
14 long-term synaptic depression GO:0060292 9.69 DRD1 DRD5
15 prepulse inhibition GO:0060134 9.69 DRD1 DRD2 DRD3
16 striatum development GO:0021756 9.68 DRD1 DRD2
17 grooming behavior GO:0007625 9.68 DRD1 DRD2
18 positive regulation of renal sodium excretion GO:0035815 9.68 DRD2 DRD3
19 G protein-coupled receptor internalization GO:0002031 9.67 DRD2 DRD3
20 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.67 DRD1 DRD3 DRD5
21 positive regulation of podosome assembly GO:0071803 9.66 CSF2 IL5
22 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.66 DRD3 DRD4
23 peristalsis GO:0030432 9.65 DRD1 DRD2
24 regulation of dopamine metabolic process GO:0042053 9.65 DRD1 DRD4
25 behavioral response to ethanol GO:0048149 9.65 DRD2 DRD4
26 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.65 DRD2 DRD3 DRD4
27 negative regulation of voltage-gated calcium channel activity GO:1901386 9.64 DRD2 DRD4
28 mating behavior GO:0007617 9.64 DRD1 DRD5
29 cellular response to catecholamine stimulus GO:0071870 9.63 DRD1 DRD5
30 cerebral cortex GABAergic interneuron migration GO:0021853 9.63 DRD1 DRD2
31 regulation of circadian sleep/wake cycle, sleep GO:0045187 9.62 CSF2 DRD3
32 behavioral response to cocaine GO:0048148 9.62 DRD1 DRD2 DRD3 DRD4
33 negative regulation of dopamine receptor signaling pathway GO:0060160 9.61 DRD2 DRD3
34 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.61 DRD1 DRD2 DRD5
35 acid secretion GO:0046717 9.6 DRD2 DRD3
36 negative regulation of NAD(P)H oxidase activity GO:0033861 9.59 DRD5 IL13
37 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.58 DRD2 DRD4
38 regulation of locomotion involved in locomotory behavior GO:0090325 9.58 DRD2 DRD3
39 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.58 DRD1 DRD2 DRD3
40 dopamine receptor signaling pathway GO:0007212 9.56 DRD1 DRD2 DRD3 DRD4
41 sensitization GO:0046960 9.55 DRD1 DRD5
42 response to histamine GO:0034776 9.54 DRD2 DRD3 DRD4
43 synaptic transmission, dopaminergic GO:0001963 9.46 DRD1 DRD2 DRD3 DRD5
44 dopamine metabolic process GO:0042417 9.26 DRD1 DRD2 DRD3 DRD4
45 response to amphetamine GO:0001975 9.02 DRD1 DRD2 DRD3 DRD4 DRD5

Molecular functions related to Chronic Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.85 DRD1 DRD2 DRD3 DRD4 DRD5
2 drug binding GO:0008144 9.54 DRD2 DRD3 DRD4
3 G-protein alpha-subunit binding GO:0001965 9.43 DRD1 DRD5
4 adrenergic receptor activity GO:0004935 9.4 DRD2 DRD3
5 dopamine binding GO:0035240 9.35 DRD1 DRD2 DRD3 DRD4 DRD5
6 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
7 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.26 DRD1 DRD5
8 dopamine neurotransmitter receptor activity GO:0004952 9.02 DRD1 DRD2 DRD3 DRD4 DRD5
9 protein binding GO:0005515 10.2 AHR AKAP17A CSF2 DNAJC13 DRD1 DRD2

Sources for Chronic Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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