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MCID: CHR100
MIFTS: 38

Chronic Ulcer of Skin

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Ulcer of Skin

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MalaCards integrated aliases for Chronic Ulcer of Skin:

Name: Chronic Ulcer of Skin 41 38 12 15
Chronic Wounds 41 63
Indolent Ulcer 12
Callous Ulcer 12
Chronic Ulcer 73

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8549
ICD10 33 L98.4
ICD9CM 35 707
Sources

Summaries for Chronic Ulcer of Skin

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PubMed Health : 63 About chronic wounds: Minor injuries to our skin usually heal quite quickly on their own. Larger wounds may need more time, and sometimes stitches are needed. But some wounds close very slowly, keep on opening up, or do not heal at all. This is often a result of circulation problems or diabetes. Poorly healing wounds are more common on the lower legs or feet. Doctors refer to a wound that that does not heal for a long time as a chronic wound. Treatment often takes a long time and can be very painful. But it is important to have good wound care and to treat the underlying condition that caused the chronic wound to develop.

MalaCards based summary : Chronic Ulcer of Skin, also known as chronic wounds, is related to burns and vascular disease. An important gene associated with Chronic Ulcer of Skin is ALB (Albumin), and among its related pathways/superpathways is FOXA2 and FOXA3 transcription factor networks. The drugs Coal tar and Pirfenidone have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and testes.

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Related Diseases for Chronic Ulcer of Skin

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Diseases related to Chronic Ulcer of Skin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 burns 30.8 ALB TTR
2 vascular disease 29.5 ALB CRP FGF2
3 decubitus ulcer 24.6 ALB BSN COPS2 CRP FGF2 LRRC19
4 pyoderma gangrenosum 11.1
5 ulcer of lower limbs 10.9
6 paramyloidosis 10.8 ALB TTR
7 kwashiorkor 10.7 ALB TTR
8 marasmus 10.7 ALB TTR
9 aleutian mink disease 10.7 ALB TTR
10 hyperthyroxinemia 10.7 ALB TTR
11 autonomic nervous system disease 10.7 ALB TTR
12 diffuse glomerulonephritis 10.7 ALB FGF2
13 protein-energy malnutrition 10.6 ALB TTR
14 demyelinating polyneuropathy 10.6 ALB TTR
15 testicular yolk sac tumor 10.6 ALB TTR
16 abdominal tuberculosis 10.5 ALB CRP
17 pyuria 10.5 ALB CRP
18 hypersensitivity reaction type iii disease 10.5 ALB CRP
19 tuberculous peritonitis 10.4 ALB CRP
20 amyloidosis aa 10.4 CRP TTR
21 acute cystitis 10.4 ALB CRP
22 peptic ulcer perforation 10.4 ALB CRP
23 prediabetes syndrome 10.4 ALB CRP
24 obstructive jaundice 10.4 ALB TTR
25 pleural disease 10.4 ALB CRP
26 acute pyelonephritis 10.4 ALB CRP
27 hemorrhagic fever with renal syndrome 10.4 ALB CRP
28 diverticulitis 10.4 CRP FGF2
29 intermittent claudication 10.4 ALB CRP
30 interstitial nephritis 10.4 ALB CRP
31 proctitis 10.3 CRP FGF2
32 bone fracture 10.3 CRP FGF2
33 pyelonephritis 10.3 ALB CRP
34 heart conduction disease 10.3 CRP TTR
35 pericardial effusion 10.3 CRP FGF2
36 typhoid fever 10.3 ALB CRP
37 appendicitis 10.2 ALB CRP
38 leukocyte disease 10.2 ALB CRP
39 coronary stenosis 10.2 ALB CRP
40 analbuminemia 10.2 ALB CRP TTR
41 dysentery 10.2 ALB CRP TTR
42 nutritional deficiency disease 10.2 ALB CRP TTR
43 acquired metabolic disease 10.1 ALB CRP TTR
44 respiratory failure 10.1 ALB CRP TTR
45 chronic kidney failure 10.1 ALB CRP TTR
46 bacterial meningitis 10.1 ALB CRP
47 homocysteinemia 10.1 ALB CRP
48 gastroenteritis 10.0 ALB CRP
49 epidermolysis bullosa 10.0
50 primary bacterial infectious disease 9.9 ALB CRP

Comorbidity relations with Chronic Ulcer of Skin via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Acute Cystitis
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Ischemic Heart Disease
Peripheral Vascular Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Chronic Ulcer of Skin:



Diseases related to Chronic Ulcer of Skin
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Symptoms & Phenotypes for Chronic Ulcer of Skin

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Drugs & Therapeutics for Chronic Ulcer of Skin

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PubMedHealth treatment related to Chronic Ulcer of Skin: 63

Chronic wounds are covered with a dressing for protection. There are other treatment options in addition to regularly changing the wound dressing: Cleaning the wound Medical staff will change the wound dressing and clean the wound regularly. The wound is normally rinsed with a saline or electrolyte solution, or simply with tap water. A technique called debridement is used to remove dead cells or inflamed tissue with tweezers. Having a wound cleaned is often painful. A topical anesthetic such as a medicated ointment can be applied to the wound area to prevent pain. Larger wounds are sometimes cleaned under general anesthetic. Wound dressings After cleaning the wound, the doctor or nurse will put on a new dressing. Things like wet compresses, films or hydrogels are used as wound dressings. Their main purpose is to keep the wound moist, absorb excess fluid and prevent infection. Advanced treatments Some hospitals also use more advanced methods to help especially difficult wounds to heal: In hyperbaric oxygen therapy, patients sit in a special pressurized chamber and breathe in oxygen. In vacuum-assisted closure (VAC therapy), fluid is continuously drawn out of the wound. Ultrasound therapy uses sound waves to treat chronic wounds. Electromagnetic therapy involves the use of magnetic cushions or mats that produce weak electric currents near the wound. Skin grafts Skin grafts may be an option for people with wounds that are too large to close on their own. The surgeon takes skin from another part of the body, often the upper leg, and transplants it to the wound. Grafts can also be made from human cell products and synthetic materials. Medication Good pain management is an important part of wound care. The pain caused by chronic wounds is often underestimated. Painkillers like acetaminophen (paracetamol) or ibuprofen tablets can help relieve mild to moderate pain. Your doctor can prescribe stronger painkillers if these do not provide enough relief. Wound dressings that contain ibuprofen are also available. Antibiotics can be used to treat wounds infected with bacteria.

Drugs for Chronic Ulcer of Skin (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Coal tar Approved Phase 4,Not Applicable 8007-45-2
2
Pirfenidone Approved, Investigational Phase 1, Phase 2 53179-13-8 40632
3
Timolol Approved Phase 2 26839-75-8 33624 5478
4
Nitric Oxide Approved Phase 2 10102-43-9 145068 160954
5
Ketanserin Investigational Phase 1, Phase 2 74050-98-9 3822
6 Analgesics Phase 1, Phase 2
7 Analgesics, Non-Narcotic Phase 1, Phase 2
8 Antihypertensive Agents Phase 1, Phase 2,Phase 2
9 Anti-Inflammatory Agents Phase 1, Phase 2
10 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
11 Antirheumatic Agents Phase 1, Phase 2
12 Contraceptive Agents Phase 1, Phase 2
13 Contraceptive Agents, Male Phase 1, Phase 2
14 Diallyl disulfide Phase 1, Phase 2
15 Neurotransmitter Agents Phase 1, Phase 2,Phase 2
16 Peripheral Nervous System Agents Phase 1, Phase 2,Phase 2
17 Platelet Aggregation Inhibitors Phase 1, Phase 2
18 Protective Agents Phase 1, Phase 2,Phase 2
19 Serotonin Agents Phase 1, Phase 2
20 Serotonin Antagonists Phase 1, Phase 2
21 Spermatocidal Agents Phase 1, Phase 2
22 Pharmaceutical Solutions Phase 2,Not Applicable
23 Adrenergic Agents Phase 2
24 Adrenergic Antagonists Phase 2
25 Adrenergic beta-Antagonists Phase 2
26 Anti-Arrhythmia Agents Phase 2
27 Anti-Asthmatic Agents Phase 2
28 Antioxidants Phase 2
29 Autonomic Agents Phase 2
30 Bronchodilator Agents Phase 2
31 Endothelium-Dependent Relaxing Factors Phase 2
32 Respiratory System Agents Phase 2
33 Vasodilator Agents Phase 2
34
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202
35
Amikacin Approved, Investigational, Vet_approved Not Applicable 37517-28-5 37768
36
Teicoplanin Approved, Investigational Not Applicable 61036-62-2
37 Anti-Bacterial Agents Not Applicable
38 Antibiotics, Antitubercular Not Applicable
39 Anti-Infective Agents Not Applicable
40 Anti-Infective Agents, Local Not Applicable
41 Polyhexamethylene biguanide Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Aurix Therapy in Venous Leg Ulcers Withdrawn NCT02940587 Phase 4
2 A Comparative Study of the Healing of Chronic Ulcers of Recessive Epidermolysis Bullosa : Dressing vs Amniotic Membrane Recruiting NCT02286427 Phase 3
3 Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers Suspended NCT00701974 Phase 2, Phase 3
4 Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers Completed NCT02632877 Phase 1, Phase 2 Pirfenidone with MODD;Ketanserin
5 Beta Blocker for Chronic Wound Healing Terminated NCT00368602 Phase 2 Timoptic
6 Topical Nitric Oxide Trial in Chronic Non-Healing Wounds Terminated NCT00823095 Phase 2 Nitric Oxide
7 To Study the Effect of Organic Light Emitting Diodes (OLED) on Cultured Fibroblast Unknown status NCT01724710
8 Ultrasonic Wound Debridement vs. Standard Sharp Debridement Completed NCT01237392 Not Applicable
9 PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4 Recruiting NCT02652169 Not Applicable PRF mixed with amikacin and teicoplanin;PRF mixed with PHMB plus Macrogolol;PRF plus normal saline
10 Topical Oxygen Therapy for Diabetic Wounds Recruiting NCT02313428 Not Applicable
11 Effectiveness of Aurix Therapy in Venous Leg Ulcers Recruiting NCT02352454 Not Applicable
12 Effectiveness of Aurix Therapy in Pressure Ulcers Recruiting NCT02352467 Not Applicable
13 Analysis of the Effects of LED Phototherapy and Electrical Stimulation in the Healing of Diabetic Ulcers Not yet recruiting NCT03250533 Not Applicable
14 A Cohort Trial Comparing AutoloGel Therapy to Usual and Customary Care in Venous Leg Ulcers Terminated NCT01817543 Not Applicable
15 AutoloGel Therapy to Usual and Customary Care in Pressure Ulcers Terminated NCT01819142 Not Applicable

Search NIH Clinical Center for Chronic Ulcer of Skin

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Ulcer of Skin cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Ulcer of Skin:
EpiDex
Grafix
Myskin
Embryonic/Adult Cultured Cells Related to Chronic Ulcer of Skin:
Epidermal keratinocytes (EpiDex PMIDs: 21071921 12846911 19538195
MSC-containing human skin substitute (Grafix) PMIDs: 23197761
Keratinocytes on a polymer film (Myskin PMIDs: 18034628
Sources

Genetic Tests for Chronic Ulcer of Skin

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Anatomical Context for Chronic Ulcer of Skin

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MalaCards organs/tissues related to Chronic Ulcer of Skin:

41
Skin, Endothelial, Testes, Bone Marrow, Bone
Sources

Publications for Chronic Ulcer of Skin

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Articles related to Chronic Ulcer of Skin:

(show top 50) (show all 69)
# Title Authors Year
1
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438151 )
2018
2
Factors Associated With Acute and Chronic Wound Complications in Patients With Soft Tissue Sarcoma With Long-term Follow-up. ( 29315173 )
2018
3
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438143 )
2018
4
MicroRNA-132 with Therapeutic Potential in Chronic Wounds. ( 28807666 )
2017
5
The expression of inflammatory cytokines, TAM tyrosine kinase receptors and their ligands is upregulated in venous leg ulcer patients: a novel insight into chronic wound immunity. ( 26192232 )
2016
6
Surgical Management of Chronic Wounds in a Buruli Ulcer Endemic Area in Central Africa. ( 26675928 )
2016
7
Biocomposites of copper-containing mesoporous bioactive glass and nanofibrillated cellulose: Biocompatibility and angiogenic promotion in chronic wound healing application. ( 27646503 )
2016
8
Topical timolol for chronic wounds in patients with junctional epidermolysis bullosa. ( 27846969 )
2016
9
Expression of the SOCS family in human chronic wound tissues: Potential implications for SOCS in chronic wound healing. ( 27635428 )
2016
10
Microbial Biofilms: Impact On Pathogenesis Of Periodontitis, Cystic Fibrosis, Chronic Wounds And Medical Device-Related Infections. ( 25877092 )
2015
11
Gelatin for purification and proliferation of primary keratinocyte culture for use in chronic wounds and burns. ( 25894191 )
2015
12
Purified type I collagen wound matrix improves chronic wound healing in patients with recessive dystrophic epidermolysis bullosa. ( 25557742 )
2015
13
Deregulated unfolded protein response in chronic wounds of diabetic ob/ob mice: a potential connection to inflammatory and angiogenic disorders in diabetes-impaired wound healing. ( 24583133 )
2014
14
Mycobacterium chelonae causing chronic wound infection and abdominal incisional hernia. ( 24943783 )
2014
15
A comparison of human cord blood- and embryonic stem cell-derived endothelial progenitor cells in the treatment of chronic wounds. ( 23127335 )
2013
16
Epidermolysis bullosa and chronic wounds: a model for wound bed preparation of fragile skin. ( 23507695 )
2013
17
A basosquamous cell carcinoma of the periorbital region arising from a chronic wound created by laser ablation of a basal cell carcinoma. ( 24220484 )
2013
18
Topography of distinct Staphylococcus aureus types in chronic wounds of patients with epidermolysis bullosa. ( 23825650 )
2013
19
Local treatment of chronic wounds: in patients with peripheral vascular disease, chronic venous insufficiency, and diabetes. ( 23413377 )
2013
20
The psychosocial impact of chronic wounds on patients with severe epidermolysis bullosa. ( 23413491 )
2012
21
Hyaluronic acid derivatives and their healing effect on burns, epithelial surgical wounds, and chronic wounds: a systematic review and meta-analysis of randomized controlled trials. ( 22564227 )
2012
22
Stem cell therapy for critical limb ischemia: what can we learn from cell therapy for chronic wounds? ( 23086986 )
2012
23
Prostaglandin Ea88 induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway. ( 22844123 )
2012
24
Tetanus in patients with chronic wounds - are we aware? ( 21923663 )
2012
25
Amniotic membrane grafting in patients with epidermolysis bullosa with chronic wounds. ( 20466177 )
2010
26
The importance of growth factors for the treatment of chronic wounds in the case of diabetic foot ulcers. ( 21289885 )
2010
27
Elephantiasis, elastin, and chronic wound healing: 19th century and contemporary viewpoints relevant to hypotheses concerning lymphedema, leprosy, erysipelas, and psoriasis--review and reflections. ( 19499764 )
2009
28
Comparative in vitro study on cytotoxicity, antimicrobial activity, and binding capacity for pathophysiological factors in chronic wounds of alginate and silver-containing alginate. ( 19614916 )
2009
29
Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF. ( 19046453 )
2008
30
Chronic wound state exacerbated by oxidative stress in Pax6+/- aniridia-related keratopathy. ( 18491289 )
2008
31
ADAM12: a potential target for the treatment of chronic wounds. ( 18604515 )
2008
32
Fibroblasts from non-healing human chronic wounds show decreased expression of beta ig-h3, a TGF-beta inducible protein. ( 18078741 )
2008
33
Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. ( 18430064 )
2008
34
Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer. ( 18284390 )
2008
35
Molecular markers in patients with chronic wounds to guide surgical debridement. ( 17515955 )
2007
36
Long-term bone marrow culture and its clinical potential in chronic wound healing. ( 18028134 )
2007
37
Transcriptome-wide analysis of blood vessels laser captured from human skin and chronic wound-edge tissue. ( 17728400 )
2007
38
Topical application of the tumour necrosis factor-alpha antibody infliximab improves healing of chronic wounds. ( 16984574 )
2006
39
Management of a chronic wound secondary to pyoderma gangrenosum following uncomplicated lower segment Caesarean section incision. ( 16441701 )
2006
40
[Effect of vacuum-assisted closure on the expression of urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor in acute and chronic wounds healing]. ( 17017150 )
2006
41
Etanercept decreases tumor necrosis factor-alpha activity in chronic wound fluid. ( 16939569 )
2006
42
Chronic wound fluid suppresses proliferation of dermal fibroblasts through a Ras-mediated signaling pathway. ( 15675969 )
2005
43
Effect of chronic wound exudates and MMP-2/-9 inhibitor on angiogenesis in vitro. ( 16079688 )
2005
44
Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. ( 15972952 )
2005
45
Expression of matrix metalloproteinase (MMP)-7 and MMP-13 and loss of MMP-19 and p16 are associated with malignant progression in chronic wounds. ( 15840104 )
2005
46
Lichen sclerosus arising from a chronic wound and coexistent with multiple sclerosis. ( 15649216 )
2005
47
Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro. ( 15978664 )
2005
48
Using a dermal skin substitute in the treatment of chronic wounds secondary to recessive dystrophic epidermolysis bullosa: a case series. ( 16319445 )
2005
49
Glycosaminoglycan: a candidate to stimulate the repair of chronic wounds. ( 16113778 )
2005
50
Altered expression of L-arginine metabolism pathway genes in chronic wounds in recessive dystrophic epidermolysis bullosa. ( 15550148 )
2004
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Variations for Chronic Ulcer of Skin

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Expression for Chronic Ulcer of Skin

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Search GEO for disease gene expression data for Chronic Ulcer of Skin.
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Pathways for Chronic Ulcer of Skin

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Pathways related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
FOXA2 and FOXA3 transcription factor networks 1
10.27 ALB TTR
Sources

GO Terms for Chronic Ulcer of Skin

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Sources for Chronic Ulcer of Skin

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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