Chronic Ulcer of Skin

Categories: Skin diseases

Aliases & Classifications for Chronic Ulcer of Skin

MalaCards integrated aliases for Chronic Ulcer of Skin:

Name: Chronic Ulcer of Skin 41 38 12 15
Chronic Wounds 41 63
Indolent Ulcer 12
Callous Ulcer 12
Chronic Ulcer 73


External Ids:

Disease Ontology 12 DOID:8549
ICD10 33 L98.4
ICD9CM 35 707
SNOMED-CT 68 19429009

Summaries for Chronic Ulcer of Skin

PubMed Health : 63 About chronic wounds: Minor injuries to our skin usually heal quite quickly on their own. Larger wounds may need more time, and sometimes stitches are needed. But some wounds close very slowly, keep on opening up, or do not heal at all. This is often a result of circulation problems or diabetes. Poorly healing wounds are more common on the lower legs or feet. Doctors refer to a wound that that does not heal for a long time as a chronic wound. Treatment often takes a long time and can be very painful. But it is important to have good wound care and to treat the underlying condition that caused the chronic wound to develop.

MalaCards based summary : Chronic Ulcer of Skin, also known as chronic wounds, is related to decubitus ulcer and pyoderma gangrenosum. An important gene associated with Chronic Ulcer of Skin is FGF2 (Fibroblast Growth Factor 2), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Coal tar and Alginic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are homeostasis/metabolism and neoplasm

Related Diseases for Chronic Ulcer of Skin

Diseases related to Chronic Ulcer of Skin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 decubitus ulcer 30.5 ALB BSN COPS2 FGF2 SETD2 TTR
2 pyoderma gangrenosum 11.3
3 ulcer of lower limbs 11.0
4 diffuse glomerulonephritis 10.2 ALB FGF2
5 pasteurellosis 10.2 ALB ELANE
6 capillary leak syndrome 10.2 ALB ELANE
7 periodontitis, chronic 10.2 MMP1 MMP8
8 tendinopathy 10.2 MMP1 MMP8
9 peptic ulcer perforation 10.2 ALB ELANE
10 vitreous disease 10.1 FGF2 PDGFB
11 paramyloidosis 10.1 ALB TTR
12 ligneous conjunctivitis 10.1 ELANE TTR
13 marasmus 10.1 ALB TTR
14 kwashiorkor 10.1 ALB TTR
15 aleutian mink disease 10.1 ALB TTR
16 thyroid crisis 10.1 ALB TTR
17 hennekam syndrome 10.1 ALB EGF
18 alpha-1-antitrypsin deficiency 10.1 ALB ELANE
19 hyperthyroxinemia 10.1 ALB TTR
20 pelvic organ prolapse 10.1 MMP1 MMP8
21 blind loop syndrome 10.1 ALB TTR
22 autonomic nervous system disease 10.1 ALB TTR
23 epidermolysis bullosa 10.1
24 gingival disease 10.1 ELANE MMP1 MMP8
25 pulmonary emphysema 10.1 ELANE MMP1 MMP8
26 analbuminemia 10.1 ALB TTR
27 aortic aneurysm, familial abdominal, 1 10.1 ELANE MMP1 MMP8
28 dysentery 10.1 ALB TTR
29 periodontal disease 10.1 ELANE MMP1 MMP8
30 gingival overgrowth 10.1 FGF2 MMP1 PDGFB
31 protein-energy malnutrition 10.0 ALB TTR
32 diabetic foot ulcers 10.0
33 gastric ulcer 10.0 EGF FGF2
34 proteasome-associated autoinflammatory syndrome 1 10.0 ALB ELANE SETD2
35 respiratory failure 10.0 ALB ELANE TTR
36 burns 10.0
37 adamantinoma of long bones 10.0 EGF FGF2 MMP1
38 demyelinating polyneuropathy 10.0 ALB TTR
39 pulmonary fibrosis, idiopathic 9.9 ELANE FGF2 MMP1 PDGFB
40 squamous cell carcinoma, head and neck 9.9 EGF FGF2 MMP1
41 testicular yolk sac tumor 9.9 ALB TTR
42 diabetes mellitus 9.9
43 hypoxia 9.9
44 ewing sarcoma 9.9 ALB FGF2 MMP1 PDGFB
45 esophageal cancer 9.9 ALB EGF FGF2 PDGFB
46 recessive dystrophic epidermolysis bullosa 9.9
47 vascular disease 9.9
48 short bowel syndrome 9.8 EGF TTR
49 hypogonadotropic hypogonadism 9.8
50 corneal disease 9.8

Comorbidity relations with Chronic Ulcer of Skin via Phenotypic Disease Network (PDN): (show all 11)

Active Peptic Ulcer Disease Acute Cystitis
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Ischemic Heart Disease
Peripheral Vascular Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Chronic Ulcer of Skin:

Diseases related to Chronic Ulcer of Skin

Symptoms & Phenotypes for Chronic Ulcer of Skin

MGI Mouse Phenotypes related to Chronic Ulcer of Skin:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 ALB ELANE FGF2 MMP1 MMP8 PDGFB
2 neoplasm MP:0002006 9.43 ALB ELANE FGF2 MMP1 MMP8 SETD2
3 vision/eye MP:0005391 9.1 BSN EGF FGF2 PDGFB SETD2 TTR

Drugs & Therapeutics for Chronic Ulcer of Skin

PubMedHealth treatment related to Chronic Ulcer of Skin: 63

Chronic wounds are covered with a dressing for protection. There are other treatment options in addition to regularly changing the wound dressing: Cleaning the wound Medical staff will change the wound dressing and clean the wound regularly. The wound is normally rinsed with a saline or electrolyte solution, or simply with tap water. A technique called debridement is used to remove dead cells or inflamed tissue with tweezers. Having a wound cleaned is often painful. A topical anesthetic such as a medicated ointment can be applied to the wound area to prevent pain. Larger wounds are sometimes cleaned under general anesthetic. Wound dressings After cleaning the wound, the doctor or nurse will put on a new dressing. Things like wet compresses, films or hydrogels are used as wound dressings. Their main purpose is to keep the wound moist, absorb excess fluid and prevent infection. Advanced treatments Some hospitals also use more advanced methods to help especially difficult wounds to heal: In hyperbaric oxygen therapy, patients sit in a special pressurized chamber and breathe in oxygen. In vacuum-assisted closure (VAC therapy), fluid is continuously drawn out of the wound. Ultrasound therapy uses sound waves to treat chronic wounds. Electromagnetic therapy involves the use of magnetic cushions or mats that produce weak electric currents near the wound. Skin grafts Skin grafts may be an option for people with wounds that are too large to close on their own. The surgeon takes skin from another part of the body, often the upper leg, and transplants it to the wound. Grafts can also be made from human cell products and synthetic materials. Medication Good pain management is an important part of wound care. The pain caused by chronic wounds is often underestimated. Painkillers like acetaminophen (paracetamol) or ibuprofen tablets can help relieve mild to moderate pain. Your doctor can prescribe stronger painkillers if these do not provide enough relief. Wound dressings that contain ibuprofen are also available. Antibiotics can be used to treat wounds infected with bacteria.

Drugs for Chronic Ulcer of Skin (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Coal tar Approved Phase 4,Not Applicable 8007-45-2
Alginic acid Approved, Investigational Phase 4 9005-32-7
3 Laxatives Phase 4
4 Carboxymethylcellulose Sodium Phase 4
5 Gastrointestinal Agents Phase 4
6 Cathartics Phase 4
7 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
Pirfenidone Approved, Investigational Phase 1, Phase 2 53179-13-8 40632
Timolol Approved Phase 2 26839-75-8 33624 5478
Nitric Oxide Approved Phase 2 10102-43-9 145068
Ketanserin Investigational Phase 1, Phase 2 74050-98-9 3822
12 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
13 Neurotransmitter Agents Phase 1, Phase 2,Phase 2
14 Analgesics Phase 1, Phase 2
15 Analgesics, Non-Narcotic Phase 1, Phase 2
16 Contraceptive Agents Phase 1, Phase 2
17 Peripheral Nervous System Agents Phase 1, Phase 2,Phase 2
18 Serotonin Antagonists Phase 1, Phase 2
19 Antihypertensive Agents Phase 1, Phase 2,Phase 2
20 Antirheumatic Agents Phase 1, Phase 2
21 Spermatocidal Agents Phase 1, Phase 2
22 Anti-Inflammatory Agents Phase 1, Phase 2
23 Serotonin Agents Phase 1, Phase 2
24 Protective Agents Phase 1, Phase 2,Phase 2
25 Platelet Aggregation Inhibitors Phase 1, Phase 2
26 Contraceptive Agents, Male Phase 1, Phase 2
27 Diallyl disulfide Phase 1, Phase 2
28 Adrenergic Antagonists Phase 2
29 Adrenergic beta-Antagonists Phase 2
30 Adrenergic Agents Phase 2
31 Anti-Arrhythmia Agents Phase 2
32 Vasodilator Agents Phase 2
33 Antioxidants Phase 2
34 Free Radical Scavengers Phase 2
35 Autonomic Agents Phase 2
36 Bronchodilator Agents Phase 2
37 Respiratory System Agents Phase 2
38 Anti-Asthmatic Agents Phase 2
39 Endothelium-Dependent Relaxing Factors Phase 2
Serotonin Investigational, Nutraceutical Phase 1, Phase 2 50-67-9 5202
Amikacin Approved, Investigational, Vet_approved Not Applicable 37517-28-5 37768
Polihexanide Approved, Investigational Not Applicable 28757-47-3
Teicoplanin Approved, Investigational Not Applicable 61036-62-2
44 Anti-Bacterial Agents Not Applicable
45 Antibiotics, Antitubercular Not Applicable
46 Anti-Infective Agents Not Applicable
47 Anti-Infective Agents, Local Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers Not yet recruiting NCT03667937 Phase 4
2 Effectiveness of Aurix Therapy in Venous Leg Ulcers Withdrawn NCT02940587 Phase 4
3 A Comparative Study of the Healing of Chronic Ulcers of Recessive Epidermolysis Bullosa : Dressing vs Amniotic Membrane Recruiting NCT02286427 Phase 3
4 Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers Suspended NCT00701974 Phase 2, Phase 3
5 Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers Completed NCT02632877 Phase 1, Phase 2 Pirfenidone with MODD;Ketanserin
6 Beta Blocker for Chronic Wound Healing Terminated NCT00368602 Phase 2 Timoptic
7 Topical Nitric Oxide Trial in Chronic Non-Healing Wounds Terminated NCT00823095 Phase 2 Nitric Oxide
8 To Study the Effect of Organic Light Emitting Diodes (OLED) on Cultured Fibroblast Unknown status NCT01724710
9 Ultrasonic Wound Debridement vs. Standard Sharp Debridement Completed NCT01237392 Not Applicable
10 PRF With Topical Antibiotics or Antiseptics in Chronical Wounds Version 1.4 Recruiting NCT02652169 Not Applicable PRF mixed with amikacin and teicoplanin;PRF mixed with PHMB plus Macrogolol;PRF plus normal saline
11 Topical Oxygen Therapy for Diabetic Wounds Recruiting NCT02313428 Not Applicable
12 Effectiveness of Aurix Therapy in Venous Leg Ulcers Recruiting NCT02352454 Not Applicable
13 Effectiveness of Aurix Therapy in Pressure Ulcers Recruiting NCT02352467 Not Applicable
14 Analysis of the Effects of LED Phototherapy and Electrical Stimulation in the Healing of Diabetic Ulcers Not yet recruiting NCT03250533 Not Applicable
15 Facilitation of Corneal Re-epithelialization After Photorefractive Keratectomy Not yet recruiting NCT03739255 Not Applicable
16 A Cohort Trial Comparing AutoloGel Therapy to Usual and Customary Care in Venous Leg Ulcers Terminated NCT01817543 Not Applicable
17 AutoloGel Therapy to Usual and Customary Care in Pressure Ulcers Terminated NCT01819142 Not Applicable

Search NIH Clinical Center for Chronic Ulcer of Skin

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Ulcer of Skin cell therapies at LifeMap Discovery.

Genetic Tests for Chronic Ulcer of Skin

Anatomical Context for Chronic Ulcer of Skin

MalaCards organs/tissues related to Chronic Ulcer of Skin:

Skin, Bone, Testes, Colon, Bone Marrow, Breast, Kidney

Publications for Chronic Ulcer of Skin

Articles related to Chronic Ulcer of Skin:

(show top 50) (show all 838)
# Title Authors Year
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438151 )
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438143 )
Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds. ( 29761496 )
Wound Care Center of Excellence: Guide to Operative Technique for Chronic Wounds. ( 29154922 )
Descriptors for Itch Related to Chronic Wounds. ( 29406292 )
Hyperbaric oxygen therapy and intermittent ischaemia in the treatment of chronic wounds. ( 29417747 )
A histological analysis of chronic wounds treated with negative pressure wound therapy to aid healing: a case series. ( 29419368 )
Assessment of Function after Free Tissue Transfer to the Lower Extremity for Chronic Wounds Using the Lower Extremity Functional Scale. ( 29452439 )
New techniques for wound management: A systematic review of their role in the management of chronic wounds. ( 29506339 )
Using a modified Delphi methodology to gain consensus on the use of dressings in chronic wounds management. ( 29509111 )
Clinical Assessment of a Biofilm-disrupting Agent for the Management of Chronic Wounds Compared With Standard of Care: A Therapeutic Approach. ( 29521641 )
When and How to Perform Cultures on Chronic Wounds? ( 29521930 )
Ozone therapy for the treatment of chronic wounds: A systematic review. ( 29536625 )
Local warming therapy for treating chronic wounds: A systematic review. ( 29561463 )
A Scoping Review of the Use of Silver-impregnated Dressings for the Treatment of Chronic Wounds. ( 29584609 )
Author Correction: Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 α induction. ( 29643419 )
Xanthine Oxidoreductase: A Novel Therapeutic Target for the Treatment of Chronic Wounds? ( 29644146 )
Phototherapy with LED Shows Promising Results in Healing Chronic Wounds in Diabetes Mellitus Patients: A Prospective Randomized Double-Blind Study. ( 29668397 )
Bromelain-based enzymatic debridement of chronic wounds: A preliminary report. ( 29696785 )
A Post-marketing Surveillance Study of Chronic Wounds Treated With a Native Collagen Calcium Alginate Dressing. ( 29718816 )
The impact of ethanol extract of propolis on biofilm forming by Proteus Mirabilis strains isolated from chronic wounds infections. ( 29726711 )
Silver absorption and toxicity evaluation of silver wound dressings in 40 patients with chronic wounds. ( 29730878 )
Conflict over the need for evidence when choosing dressings for chronic wounds. ( 29738304 )
Effects of Low-Power Light Therapy on the Tissue Repair Process of Chronic Wounds in Diabetic Feet. ( 29882738 )
Multiphotonic staging of chronic wounds and evaluation of sterile, optical transparent bacterial nanocellulose covering: A diagnostic window into human skin. ( 29923636 )
Barriers and enablers to patient recruitment for randomised controlled trials on treatment of chronic wounds: A systematic review. ( 29927054 )
Assessment of chronic wounds in adults: an integrative review. ( 29947700 )
Smart Wound Dressings for Diabetic Chronic Wounds. ( 29949930 )
Economic Evaluations of Guideline-Based Care for Chronic Wounds: a Systematic Review. ( 29968020 )
Medical Devices; General and Plastic Surgery Devices; Classification of the Extracorporeal Shock Wave Device for Treatment of Chronic Wounds. Final order. ( 29969205 )
Monitoring and Molecular Characterization of Staphylococcus aureus Isolated from Chronic Wounds. ( 29975199 )
Smart Bandage for Monitoring and Treatment of Chronic Wounds. ( 29978547 )
Assessment of pain in chronic wounds: A survey of Australian health care practitioners. ( 29999235 )
Early detection and monitoring of chronic wounds using low-cost, omniphobic paper-based smart bandages. ( 30014943 )
Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience. ( 30016136 )
Use of a gelling fibre dressing in complex surgical or chronic wounds: a case series. ( 30016138 )
UHMS Position Statement: Topical Oxygen for Chronic Wounds. ( 30028926 )
Controversy on the Use of Povidone-Iodine in Chronic Wounds. ( 30089302 )
Treatment of human chronic wounds with autologous extracellular matrix/stromal vascular fraction gel: A STROBE-compliant study. ( 30095623 )
Co-occurrence of Anaerobes in Human Chronic Wounds. ( 30141127 )
Flexible agar-sericin hydrogel film dressing for chronic wounds. ( 30177201 )
Cell salvage in acute and chronic wounds: a potential treatment strategy. Experimental data and early clinical results. ( 30204575 )
Thermal imaging and planimetry evaluation of the results of chronic wounds treatment with hyperbaric oxygen therapy. ( 30238703 )
Chronic wounds in Australia: A systematic review of key epidemiological and clinical parameters. ( 30259680 )
Iron and iron-dependent reactive oxygen species in the regulation of macrophages and fibroblasts in non-healing chronic wounds. ( 30261274 )
Models Used in Clinical Decision Support Systems Supporting Healthcare Professionals Treating Chronic Wounds: Systematic Literature Review. ( 30291078 )
Use of wet-to-moist cleansing with different irrigation solutions to reduce bacterial bioburden in chronic wounds. ( 30307816 )
Effects and safety of atmospheric low-temperature plasma on bacterial reduction in chronic wounds and wound size reduction: A systematic review and meta-analysis. ( 30311743 )
Pain management of chronic wounds: Diabetic ulcers and beyond. ( 30314556 )
Management of Chronic Wounds-2018. ( 30326512 )

Variations for Chronic Ulcer of Skin

Expression for Chronic Ulcer of Skin

Search GEO for disease gene expression data for Chronic Ulcer of Skin.

Pathways for Chronic Ulcer of Skin

GO Terms for Chronic Ulcer of Skin

Cellular components related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB EGF ELANE FGF2 MMP8 PDGFB
2 platelet alpha granule lumen GO:0031093 9.33 ALB EGF PDGFB
3 extracellular region GO:0005576 9.23 ALB EGF ELANE FGF2 MMP1 MMP8

Biological processes related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.76 EGF FGF2 SETD2
2 MAPK cascade GO:0000165 9.73 EGF FGF2 PDGFB
3 cellular protein metabolic process GO:0044267 9.72 ALB MMP1 TTR
4 extracellular matrix organization GO:0030198 9.71 FGF2 PDGFB TTR
5 peptidyl-tyrosine phosphorylation GO:0018108 9.63 EGF FGF2 PDGFB
6 positive regulation of protein kinase B signaling GO:0051897 9.61 EGF FGF2 PDGFB
7 positive regulation of protein tyrosine kinase activity GO:0061098 9.58 EGF PDGFB
8 collagen catabolic process GO:0030574 9.57 MMP1 MMP8
9 platelet degranulation GO:0002576 9.54 ALB EGF PDGFB
10 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.52 FGF2 PDGFB
11 positive regulation of DNA binding GO:0043388 9.51 EGF MMP8
12 phosphatidylinositol phosphorylation GO:0046854 9.5 EGF FGF2 PDGFB
13 endodermal cell differentiation GO:0035987 9.49 MMP8 SETD2
14 positive regulation of mitotic nuclear division GO:0045840 9.48 EGF PDGFB
15 positive regulation of DNA biosynthetic process GO:2000573 9.4 FGF2 PDGFB
16 extracellular matrix disassembly GO:0022617 9.33 ELANE MMP1 MMP8
17 paracrine signaling GO:0038001 9.26 FGF2 PDGFB
18 positive regulation of hyaluronan biosynthetic process GO:1900127 8.96 EGF PDGFB
19 positive regulation of MAP kinase activity GO:0043406 8.92 EGF ELANE FGF2 PDGFB

Molecular functions related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.54 ELANE MMP1 MMP8
2 growth factor activity GO:0008083 9.43 EGF FGF2 PDGFB
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 EGF FGF2 PDGFB
4 chemoattractant activity GO:0042056 9.32 FGF2 PDGFB
5 endopeptidase activity GO:0004175 9.13 ELANE MMP1 MMP8
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 EGF FGF2 PDGFB

Sources for Chronic Ulcer of Skin

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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