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MCID: CHR100
MIFTS: 55

Chronic Ulcer of Skin

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Ulcer of Skin

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MalaCards integrated aliases for Chronic Ulcer of Skin:

Name: Chronic Ulcer of Skin 40 12 15 37 17
Chronic Wounds 40 62
Indolent Ulcer 12
Callous Ulcer 12
Chronic Ulcer 71

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8549
ICD9CM 34 707
SNOMED-CT 67 19429009
ICD10 32 L98.4
UMLS 71 C0157738 C0333297
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Summaries for Chronic Ulcer of Skin

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PubMed Health : 62 About chronic wounds: Minor injuries to our skin usually heal quite quickly on their own. Larger wounds may need more time, and sometimes stitches are needed. But some wounds close very slowly, keep on opening up, or do not heal at all. This is often a result of circulation problems or diabetes. Poorly healing wounds are more common on the lower legs or feet. Doctors refer to a wound that that does not heal for a long time as a chronic wound. Treatment often takes a long time and can be very painful. But it is important to have good wound care and to treat the underlying condition that caused the chronic wound to develop.

MalaCards based summary : Chronic Ulcer of Skin, also known as chronic wounds, is related to gastrointestinal ulceration, recurrent, with dysfunctional platelets and pyoderma. An important gene associated with Chronic Ulcer of Skin is FGF2 (Fibroblast Growth Factor 2), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Polihexanide and Zinc have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and colon, and related phenotypes are homeostasis/metabolism and cardiovascular system

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Related Diseases for Chronic Ulcer of Skin

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Diseases related to Chronic Ulcer of Skin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 427)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal ulceration, recurrent, with dysfunctional platelets 31.1 PDGFB FGF2 EGF
2 pyoderma 30.7 TNF MMP1 CRP
3 venous insufficiency 30.6 VEGFA TIMP2 MMP1 ELANE CRP
4 chronic venous insufficiency 30.6 VEGFA TIMP2 MMP1 CRP
5 periodontitis, chronic 30.6 MMP8 MMP1
6 erysipelas 30.4 TNF ELANE CRP
7 lymphangitis 30.4 HECTD4 CRP ALB
8 vascular disease 30.2 VEGFA TNF FGF2 CRP ALB
9 leprosy 3 30.2 TNF HECTD4 ALB
10 gastric ulcer 30.0 VEGFA TNF FGF2 EGF
11 limb ischemia 29.9 VEGFA TNF TIMP2 FGF2
12 intermittent claudication 29.8 VEGFA FGF2 CRP ALB
13 fasciitis 29.8 TNF MMP1 HECTD4 CRP
14 skin disease 29.8 TNF MMP1 FGF7 FGF2 CRP ALB
15 bone resorption disease 29.7 TNF HECTD4 CRP ALB
16 arthropathy 29.7 TNF MMP13 MMP1 CRP
17 keratitis, hereditary 29.7 VEGFA TNF FGF2
18 neutropenia 29.7 TNF ELANE CRP ALB
19 peripheral artery disease 29.7 VEGFA TNF FGF2 CRP
20 sickle cell anemia 29.7 TNF CRP ALB
21 osteoarthritis 29.6 TNF MMP13 MMP1 CRP
22 sleep apnea 29.6 VEGFA TNF CRP ALB
23 peritonitis 29.6 TNF MMP8 ELANE CRP ALB
24 end stage renal disease 29.6 VEGFA TNF CRP ALB
25 corneal disease 29.6 VEGFA TNF FGF2 EGF ALB
26 decubitus ulcer 29.5 VEGFA TTR TNF SLC7A1 PLEKHG5 PDGFB
27 periodontitis 29.4 VEGFA TNF MMP8 MMP13 MMP1 ELANE
28 pneumonia 29.3 TTR TNF MMP8 ELANE CRP ALB
29 peripheral nervous system disease 29.2 VEGFA TTR TNF HECTD4 FGF2 CRP
30 eye disease 29.1 VEGFA TNF MMP1 FGF2 EGF CRP
31 bone inflammation disease 29.0 VEGFA TNF MMP13 MMP1 HECTD4 CRP
32 ulcer of lower limbs 11.2
33 adamantinoma of long bones 10.6 FGF2 EGF
34 tendinopathy 10.6 MMP8 MMP1
35 acute dacryoadenitis 10.6 HECTD4 CRP
36 cleft palate, cardiac defects, and mental retardation 10.6 MMP8 HECTD4
37 chronic duodenal ileus 10.5 CRP ALB
38 ligneous conjunctivitis 10.5 TTR ELANE
39 fungal keratitis 10.5 TIMP2 MMP8
40 neurogenic arthropathy 10.5 HECTD4 CRP
41 hypertensive heart disease 10.5 TIMP2 MMP1 FGF2
42 tuberculous peritonitis 10.5 CRP ALB
43 peptic ulcer perforation 10.4 CRP ALB
44 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
45 aspiration pneumonia 10.4 MMP8 CRP ALB
46 spinal stenosis 10.4 TIMP2 MMP13 MMP1
47 rapidly progressive glomerulonephritis 10.4 ELANE CRP ALB
48 gingival fibromatosis 10.4 TIMP2 MMP1 EGF
49 viral meningitis 10.4 TIMP2 MMP1 CRP
50 ascending cholangitis 10.4 CRP ALB

Comorbidity relations with Chronic Ulcer of Skin via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Peripheral Vascular Disease
Protein-Energy Malnutrition Schizophreniform Disorder

Graphical network of the top 20 diseases related to Chronic Ulcer of Skin:



Diseases related to Chronic Ulcer of Skin
Sources

Symptoms & Phenotypes for Chronic Ulcer of Skin

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MGI Mouse Phenotypes related to Chronic Ulcer of Skin:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ALB CRP ELANE FGF2 FGF7 MMP1
2 cardiovascular system MP:0005385 9.96 ALB CRP FGF2 MMP13 PDGFB PLEKHG5
3 immune system MP:0005387 9.73 ALB CRP EGF ELANE FGF7 MMP1
4 neoplasm MP:0002006 9.17 ALB ELANE FGF2 MMP1 MMP8 TNF
Sources

Drugs & Therapeutics for Chronic Ulcer of Skin

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PubMed Health treatment related to Chronic Ulcer of Skin: 62

Chronic wounds are covered with a dressing for protection. There are other treatment options in addition to regularly changing the wound dressing: Cleaning the wound Medical staff will change the wound dressing and clean the wound regularly. The wound is normally rinsed with a saline or electrolyte solution, or simply with tap water . A technique called debridement is used to remove dead cells or inflamed tissue with tweezers. Having a wound cleaned is often painful. A topical anesthetic such as a medicated ointment can be applied to the wound area to prevent pain. Larger wounds are sometimes cleaned under general anesthetic. Wound dressings After cleaning the wound , the doctor or nurse will put on a new dressing. Things like wet compresses, films or hydrogels are used as wound dressings. Their main purpose is to keep the wound moist, absorb excess fluid and prevent infection . Advanced treatments Some hospitals also use more advanced methods to help especially difficult wounds to heal: In hyperbaric oxygen therapy , patients sit in a special pressurized chamber and breathe in oxygen. In vacuum-assisted closure (VAC therapy ), fluid is continuously drawn out of the wound . Ultrasound therapy uses sound waves to treat chronic wounds . Electromagnetic therapy involves the use of magnetic cushions or mats that produce weak electric currents near the wound . Skin grafts Skin grafts may be an option for people with wounds that are too large to close on their own. The surgeon takes skin from another part of the body, often the upper leg, and transplants it to the wound . Grafts can also be made from human cell products and synthetic materials. Medication Good pain management is an important part of wound care. The pain caused by chronic wounds is often underestimated. Painkillers like acetaminophen (paracetamol) or ibuprofen tablets can help relieve mild to moderate pain. Your doctor can prescribe stronger painkillers if these do not provide enough relief. Wound dressings that contain ibuprofen are also available. Antibiotics can be used to treat wounds infected with bacteria .

Drugs for Chronic Ulcer of Skin (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 144)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 4 28757-47-3
2
Zinc Approved, Investigational Phase 4 7440-66-6 32051
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Betaine Approved, Nutraceutical Phase 4 107-43-7 247
5 Octenidine Investigational Phase 4 71251-02-0
6 Anti-Bacterial Agents Phase 4
7 Pulmonary Surfactants Phase 4
8 Laxatives Phase 4
9 Cathartics Phase 4
10 Carboxymethylcellulose Sodium Phase 4
11 Gastrointestinal Agents Phase 4
12 Benzalkonium Compounds Phase 4
13 Hypoglycemic Agents Phase 4
14 insulin Phase 4
15 Insulin, Globin Zinc Phase 4
16 Anesthetics Phase 4
17 Anti-Infective Agents, Local Phase 4
18 Anti-Infective Agents Phase 4
19
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
20
Pantoprazole Approved Phase 3 102625-70-7 4679
21
Metronidazole Approved Phase 3 443-48-1 4173
22
Becaplermin Approved, Investigational Phase 3 165101-51-9
23
Morphine Approved, Investigational Phase 3 57-27-2 5288826
24
Thrombin Approved, Investigational Phase 3
25 Trace Elements Phase 2, Phase 3
26 Nutrients Phase 2, Phase 3
27 Micronutrients Phase 2, Phase 3
28 Proton Pump Inhibitors Phase 3
29 Antacids Phase 3
30 Anti-Ulcer Agents Phase 3
31 Antiprotozoal Agents Phase 3
32 Antiparasitic Agents Phase 3
33 Disinfectants Phase 3
34 Mitogens Phase 3
35
protease inhibitors Phase 3
36 HIV Protease Inhibitors Phase 3
37 Angiogenesis Inducing Agents Phase 3
38 Narcotics Phase 3
39 Analgesics, Opioid Phase 3
40 Analgesics Phase 3
41 Hemostatics Phase 3
42 Coagulants Phase 3
43
leucovorin Approved Phase 2 58-05-9 6006 143
44
Trimethoprim Approved, Vet_approved Phase 2 738-70-5 5578
45
Methyl salicylate Approved, Vet_approved Phase 2 119-36-8 4133
46
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
47
Papain Approved Phase 1, Phase 2 9001-73-4
48
Hydroxychloroquine Approved Phase 1, Phase 2 118-42-3 3652
49
Petrolatum Approved, Investigational Phase 1, Phase 2 8009-03-8
50
Carbon monoxide Approved, Investigational Phase 2 630-08-0 281

Interventional clinical trials:

(show top 50) (show all 293)
# Name Status NCT ID Phase Drugs
1 Post-Market Clinical Evaluation of the Spiracur SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
3 Wound Fluid Protease Levels During Use of Novel Wound Dressing Completed NCT01567150 Phase 4
4 A Prospective, Open Labelled, Multicentre Evaluation of the Use of EZCareâ—Š in the Management of Acute and Chronic Wounds Completed NCT00994162 Phase 4
5 Evaluation of Provase in the Post Burn Rehabilitation Population for Itch Control and Moisturization Properties Completed NCT00782054 Phase 4
6 Effect of Pulsed Electromagnetic Fields on Postoperative Recovery After TRAM Flap Breast Reconstruction Completed NCT01262599 Phase 4
7 A Prospective, Double-blind, Randomized, Controlled Clinical Trial Comparing Standard Wound Care With Adjunctive Hyperbaric Oxygen Therapy (HBOT) to Standard Wound Care Only for the Treatment of Chronic, Non-healing Ulcers of the Lower Limb in Patients With Diabetes Mellitus. Completed NCT00621608 Phase 4
8 Prospective, Randomized Clinical Trial of a Silver Eluting Dressing System for Prevention of Lower Extremity Revascularization Wound Complications Completed NCT01229358 Phase 4
9 A Prospective Randomized Trial Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation Completed NCT01939145 Phase 4 Normal saline
10 Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers: An Open, Controlled, Randomized Study, With Blinded Endpoint (PROBE Trial): CUCO-UV Study Recruiting NCT03667937 Phase 4
11 GrafixPL PRIME Evaluation Case Study Active, not recruiting NCT03742440 Phase 4
12 Investigating the Effect of an Anti-Biofilm Solution to Reduce Bacterial Burden and Accelerate Healing in Chronic Wounds. Active, not recruiting NCT03686904 Phase 4 Benzalkonium Gel;benzalkonium irrigation
13 Effect of Insulin on Wound Healing- A Randomized Controlled Trial Not yet recruiting NCT04390815 Phase 4 Insulin
14 The F.L.I.G.H.T. (Fluorescence Image-Guided Healing Trial) for Diabetic Foot Ulcers: A Phase IV Trial Not yet recruiting NCT04163055 Phase 4
15 Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY Suspended NCT02863744 Phase 4
16 Randomized, Double-blind, Single-center, Placebo-controlled Study to Evaluate the Efficacy of Octenisept® in Patients With Chronic Wounds Terminated NCT01434914 Phase 4 octenisept®;Placebo
17 Restoring Equilibrium and Wound Stimulation to Promote Healing Of Non-healing DFUs Terminated NCT01608776 Phase 4
18 A Prospective Single Center Within Subject Controlled Observational Study to Evaluate Apligraf(R) in Nonhealing Wounds of Subjects With Epidermolysis Bullosa Terminated NCT01619670 Phase 4
19 A Randomized Comparison of AmnioClearâ„¢ Human Allograft Amniotic Membrane vs. Moist Wound Dressing in the Treatment of Diabetic Wounds Withdrawn NCT02120755 Phase 4
20 Stem Cells In Wound Healing With Collagen Matrix as a Carrier Withdrawn NCT02314416 Phase 4
21 A Multi-Center, Prospective, Randomized Trial Comparing the Effectiveness of Aurix Therapy to Usual and Customary Care in Venous Leg Ulcers Withdrawn NCT02940587 Phase 4
22 A Prospective, Randomized, Controlled Study of MIST Therapy's Effectiveness in Wound Bed Preparation and the Role of Bacterial Biofilm in Subjects Presenting With Chronic, Non-healing Wounds Withdrawn NCT01125735 Phase 4
23 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
24 Evaluation of the Therapeutic Effect of Platelet Rich Plasma in Melasma Unknown status NCT03308370 Phase 3
25 A Prospective, Open, Non-controlled Proof-of-concept Investigation to Evaluate the Function of a New Silicon Cover Film and an On-top Suction Device to be Used in a NPWT System in the Treatment of Acute and Chronic Wounds Completed NCT01286857 Phase 2, Phase 3
26 Evaluation of a Medical Food for Chronic Wounds Completed NCT00711217 Phase 3
27 A Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Soluble Beta-1,3/1,6-glucan (SBG) in Chronic Foot Ulcers in Patients With Diabetes Completed NCT00804414 Phase 3 SBG;Placebo Comparator
28 An Open Randomised Comparative Study to Evaluate the Performance of AQUACEL® Extraâ„¢ in Venous Leg Ulcers Completed NCT01591434 Phase 3
29 A Comparative Efficacy Study: Treatments of Non-Healing Diabetic Foot Ulcers Completed NCT01450943 Phase 3
30 A Prospective, Multi-Center, Randomized, Controlled Clinical Investigation of Dermagraft(R) in Subjects With Venous Leg Ulcers DEVO-Trial Completed NCT00909870 Phase 3
31 Open Multi-centre Investigation to Evaluate Signs and Symptoms of Local Inflammation/Infection on Chronic Ulcers and Partial Thickness Burns When Using Mepilex Border Ag as an Anti-microbial Wound Dressing Completed NCT01214811 Phase 3
32 Long-term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints Completed NCT00261300 Phase 3 Pantoprazole
33 Randomized Controlled Study for Evaluation of the Impact of Red Wine, White Wine and Beer Intake on Contrast-Medium Induced Acute Kidney Injury Completed NCT01562925 Phase 3
34 Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide: Randomized Clinical Trial Completed NCT02394821 Phase 3 Polihexanide 2%;Metronidazole 0.8%
35 VIITAL: A Phase 3 Study of EB-101 for the Treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB) Recruiting NCT04227106 Phase 3
36 Proof of Concept Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
37 Clinical Relevance of the Antimicrobial Resistance Testing in the Treatment of Chronic Wounds With Antiseptics Not yet recruiting NCT04172363 Phase 3 Octenisept and Serasept
38 Phase III Study Evaluating the Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds Terminated NCT02028923 Phase 3 Morphine gel
39 Safety And Efficacy Of Topical Platelet Rich Plasma And Thrombin Coagulum In The Treatment Of Recalcitrant Venous Stasis Ulcers Terminated NCT02802995 Phase 3 PRP/thrombin mixture
40 A Phase 2B Randomized Double Blind Placebo Controlled Study to Evaluate the Safety and Efficacy of JVS-100 Administered by Direct Intramuscular Injection as Adjunct to Revascularization of Infrapopliteal Lesions in Subjects With Advanced Peripheral Artery Disease and Tissue Loss Unknown status NCT02544204 Phase 2
41 Lidorestat (IDD 676) for the Treatment of Diabetic Neuropathy Unknown status NCT00043797 Phase 2 Lidorestat (IDD 676)
42 Effect of SACCHACHITIN on Healing of Chronic Wound ---A Clinical Trial Unknown status NCT00117364 Phase 2 SACCHACHITIN patch
43 Study Assessing Safety and Efficacy of B-cure Laser Treating Diabetic Chronic Wounds Unknown status NCT01493895 Phase 1, Phase 2
44 A Double-blind, Placebo-controlled Clinical Trial to Evaluate the Effects of Catechol-O-Methyltransferase (COMT) Inhibition on Cognition and Neuropsychiatric Symptoms in Patients With a History of Acquired Brain Injuries Unknown status NCT03273062 Phase 2 Tolcapone 200 MG
45 A Multi-Center, Prospective, Open Label Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers. Completed NCT01396837 Phase 2
46 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds Completed NCT02092870 Phase 2 Adipose derived stem cells
47 Open Label Study (Phase 2) to Evaluate the Safety, Tolerance and Efficacy of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs Completed NCT01111695 Phase 2
48 Prospective Randomized Double Blind Clinical Trial of Polyhexamethylene Biguanide Impregnated Foam Dressing Completed NCT00618787 Phase 2
49 Treatment of Pressure Ulcers With Autologous Bone Marrow Stem Cells in Spinal Cord Injury Patients.Phase I/II Study. Completed NCT01572376 Phase 1, Phase 2
50 Chronic Wounds Reference Nurse and Telematic Interconsultation Program for Pressure Ulcers in Primary Care: Evaluation of Effectiveness and Cost Reduction Completed NCT01877681 Phase 2

Search NIH Clinical Center for Chronic Ulcer of Skin

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Ulcer of Skin cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Ulcer of Skin:
EpiDex, follicular keratinocyte sheets for treatment of chronic wounds
Grafix, mesenchymal stem cells for wound healing
Myskin, keratinocytes on a polymer film patch for treatment of skin ulcers
Embryonic/Adult Cultured Cells Related to Chronic Ulcer of Skin:
Epidermal keratinocytes (EpiDex) PMIDs: 21071921 12846911 19538195
MSC-containing human skin substitute (Grafix) PMIDs: 23197761
Keratinocytes on a polymer film (Myskin) PMIDs: 18034628
Sources

Genetic Tests for Chronic Ulcer of Skin

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Anatomical Context for Chronic Ulcer of Skin

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MalaCards organs/tissues related to Chronic Ulcer of Skin:

40
Skin, Bone, Colon, Testes, Endothelial, Brain, Bone Marrow
Sources

Publications for Chronic Ulcer of Skin

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Articles related to Chronic Ulcer of Skin:

(show top 50) (show all 4684)
# Title Authors PMID Year
1
Expression of natural antimicrobial peptide beta-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers. 61 54
16201312 2005
2
[Application of recombinant human epidermal growth factor on chronic ulcer wound]. 61 54
11826651 2002
3
Differential expression of tissue inhibitors of metalloproteinases (TIMP-1, -2, -3, and -4) in normal and aberrant wound healing. 61 54
10414498 1999
4
Distinct populations of stromal cells express collagenase-3 (MMP-13) and collagenase-1 (MMP-1) in chronic ulcers but not in normally healing wounds. 61 54
9204962 1997
5
Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin. 61 54
8601737 1996
6
Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing. 54 61
1719945 1991
7
Gene-activated dermal equivalents to accelerate healing of diabetic chronic wounds by regulating inflammation and promoting angiogenesis. 61
32420517 2020
8
Data supporting exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing. 61
32462062 2020
9
Preparation and characterization of bioactive silk fibroin/paramylon blend films for chronic wound healing. 61
31730986 2020
10
Silver nanoparticles: Advanced and promising technology in diabetic wound therapy. 61
32409075 2020
11
Mesenchymal Stem Cell/Multipotent Stromal Cell Augmentation of Wound Healing: Lessons from the Physiology of Matrix and Hypoxia Support. 61
32294456 2020
12
Free Anterolateral Thigh Versus Vastus Lateralis Muscle Flaps for Coverage of Lower Extremity Defects in Chronic Wounds. 61
32539286 2020
13
Practical context of enzymatic treatment for wound healing: A secreted protease approach (Review). 61
32440346 2020
14
Human mesenchymal stem cells-conditioned medium improves diabetic wound healing mainly through modulating fibroblast behaviors. 61
31786709 2020
15
Nature-Inspired Bacterial Cellulose/Methylglyoxal (BC/MGO) Nanocomposite for Broad-Spectrum Antimicrobial Wound Dressing. 61
32567254 2020
16
Bioshell Calcium Oxide (BiSCaO) Ointment for the Disinfection and Healing of Pseudomonas aeruginosa-Infected Wounds in Hairless Rats. 61
32545309 2020
17
The use of intermittent pneumatic compression of the thigh to affect arterial and venous blood flow proximal to a chronic wound site. 61
32558254 2020
18
Efficacy of Recombinant Human Epidermal Growth Factor (Regen-D 150) in Healing Diabetic Foot Ulcers: A Hospital-Based Randomized Controlled Trial. 61
31878810 2020
19
Bioengineered Hybrid Collagen Scaffold Tethered with Silver-Catechin Nanocomposite Modulates Angiogenesis and TGF-β Toward Scarless Healing in Chronic Deep Second Degree Infected Burns. 61
32378364 2020
20
Mutual inter-regulation between iNOS and TGF-β1: Possible molecular and cellular mechanisms of iNOS in wound healing. 61
32497615 2020
21
Diagnostics for Wound Infections. 61
32496977 2020
22
Staphylococcus aureus Biofilm Infection Compromises Wound Healing by Causing Deficiencies in Granulation Tissue Collagen. 61
30614873 2020
23
HONEY DRESSING IN WOUND TREATMENT: A SYSTEMATIC REVIEW. 61
32507418 2020
24
Nanotechnology Approaches in Chronic Wound Healing. 61
32320364 2020
25
Paper-based human neutrophil elastase detection device for clinical wound monitoring. 61
32573571 2020
26
Beta-adrenergic antagonist for the healing of chronic diabetic foot ulcers: study protocol for a prospective, randomized, double-blinded, controlled and parallel-group study. 61
32513257 2020
27
Clinical evaluation of polyabsorbent TLC-NOSF dressings on chronic wounds: a prospective, observational, multicentre study of 1140 patients. 61
32530781 2020
28
Antioxidant dressing therapy versus standard wound care in chronic wounds (the REOX study): study protocol for a randomized controlled trial. 61
32513260 2020
29
Towards the Development of a Novel Ex Ovo Model of Infection to Pre-Screen Biomaterials Intended for Treating Chronic Wounds. 61
32498233 2020
30
Challenges and New Therapeutic Approaches in the Management of Chronic Wounds. 61
32576127 2020
31
Protein tyrosine phosphatase 1B inhibition as a potential therapeutic target for chronic wounds in diabetes. 61
32504834 2020
32
Implementation and Analysis of Two Knowledge Base Approaches for the Treatment of Chronic Wounds. 61
32570455 2020
33
Evaluation of the Efficacy of Ultrapulsed CO2 Laser in Chronic Wounds. 61
32548904 2020
34
A Device to Predict Short-Term Healing Outcome of Chronic Wounds. 61
32286205 2020
35
Nanomedicine in Healing Chronic Wounds: Opportunities and Challenges. 61
32519875 2020
36
Absorbable Thioether Grafted Hyaluronic Acid Nanofibrous Hydrogel for Synergistic Modulation of Inflammation Microenvironment to Accelerate Chronic Diabetic Wound Healing. 61
32338465 2020
37
Evidence-Based Review of Anti-Biofilm Agents for Wound Care. 61
32496980 2020
38
Topical delivery of growth factors and metal/metal oxide nanoparticles to infected wounds by polymeric nanoparticles: an overview. 61
32536223 2020
39
The Zone Model: A conceptual model for understanding the microenvironment of chronic wound infection. 61
32529778 2020
40
Current in vitro biofilm-infected chronic wound models for developing new treatment possibilities. 61
32496982 2020
41
Effect of photobiomodulation on cellular migration and survival in diabetic and hypoxic diabetic wounded fibroblast cells. 61
32483750 2020
42
Nanomaterials for Angiogenesis in Skin Tissue Engineering. 61
31964266 2020
43
Approaches to modulate the chronic wound environment using localized nucleic acid delivery. 61
32496978 2020
44
Self-Assembled Nanomaterials for Chronic Skin Wound Healing. 61
32487014 2020
45
Augmented healing of full thickness chronic excision wound by rosmarinic acid loaded chitosan encapsulated graphene nanopockets. 61
32338544 2020
46
Application of Easy Wet Healing Therapy for Chronic Noninfectious Wounds in Limbs. 61
32517523 2020
47
Adipose-Derived Mesenchymal Stromal Cells in Regenerative Medicine: State of Play, Current Clinical Trials, and Future Prospects. 61
32470315 2020
48
Propolis loaded liposomes: evaluation of antimicrobial and antioxidant activities. 61
30913939 2020
49
Biodistribution and intracellular localization of hyaluronan and its nanogels. A strategy to target intracellular S. aureus in persistent skin infections. 61
32553788 2020
50
Hair Follicle Transplantation for Wound Repair. 61
32522101 2020
Sources

Variations for Chronic Ulcer of Skin

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Expression for Chronic Ulcer of Skin

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Search GEO for disease gene expression data for Chronic Ulcer of Skin.
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Pathways for Chronic Ulcer of Skin

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Pathways related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.88 VEGFA TTR TNF TIMP2 PDGFB OSCAR
2
GPCR Pathway 63
Show member pathways
 13.62 VEGFA TIMP2 PDGFB MMP8 MMP13 MMP1
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.3 VEGFA TNF PDGFB MMP1 FGF7 FGF2
4
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.16 VEGFA TNF TIMP2 SLC7A1 PDGFB FGF7
5
PI3K-Akt signaling pathway 36
Show member pathways
 12.92 VEGFA TNF PDGFB FGF7 FGF2 EGF
6
Pathways in cancer 36
12.7 VEGFA PLEKHG5 PDGFB MMP1 FGF7 FGF2
7
Ras signaling pathway 36
Show member pathways
 12.67 VEGFA PDGFB FGF7 FGF2 EGF
8
MAPK signaling pathway 36 1
12.67 VEGFA TNF PDGFB FGF7 FGF2 EGF
9
NF-KappaB Family Pathway 63
Show member pathways
 12.59 TNF TIMP2 PDGFB FGF7 FGF2 EGF
10
Degradation of the extracellular matrix 65
Show member pathways
 12.51 TTR TIMP2 PDGFB MMP8 MMP13 MMP1
11
RhoGDI Pathway 63
Show member pathways
 12.33 VEGFA FGF7 FGF2 EGF
12
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.33 TIMP2 PDGFB FGF7 FGF2 EGF
13
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.18 TNF TIMP2 PDGFB FGF7 FGF2
14
Colorectal Cancer Metastasis 63
12.1 VEGFA TNF MMP1 EGF
15
Interleukin-4 and 13 signaling 65
11.89 VEGFA TNF MMP1 FGF2
16
Angiogenesis (CST) 4
11.78 TIMP2 MMP13 FGF2
17
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.76 VEGFA PDGFB FGF7 FGF2 EGF ALB
18
Bladder cancer 36 1
11.67 VEGFA MMP1 EGF
19
Neural Stem Cells and Lineage-specific Markers 64
11.66 VEGFA PDGFB FGF2 EGF
20
G-protein signaling_RhoA regulation pathway 22
11.65 TIMP2 PDGFB FGF7 FGF2 EGF
21
Endochondral Ossification 1
11.61 VEGFA MMP13 FGF2
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.59 VEGFA TNF MMP1
23
Cell adhesion_ECM remodeling 22
11.57 TIMP2 MMP13 MMP1
24
Lung fibrosis 1
11.52 TNF PDGFB FGF7 FGF2 EGF
25
Cell adhesion_Plasmin signaling 22
11.46 VEGFA MMP13 FGF2
26
Differentiation Pathway 1
11.39 VEGFA PDGFB FGF2 EGF
27
Cell adhesion_Cell-matrix glycoconjugates 22
11.33 TIMP2 MMP1 ELANE
28
Matrix Metalloproteinases 1
Show member pathways
 11.1 TNF TIMP2 MMP8 MMP13 MMP1 ELANE
29
Angiogenesis (WikiPathways) 1
11.05 VEGFA TIMP2 PDGFB FGF2
30
Vemurafenib Pathway, Pharmacodynamics 60
10.99 VEGFA PDGFB FGF7 FGF2 EGF
31
G-protein signaling_Rap2B regulation pathway 22
10.93 TNF TIMP2 PDGFB FGF7 FGF2 EGF
Sources

GO Terms for Chronic Ulcer of Skin

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Cellular components related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.85 VEGFA TNF TIMP2 PDGFB OSCAR ELANE
2 extracellular space GO:0005615 9.77 VEGFA TTR TNF TIMP2 PDGFB MMP8
3 extracellular matrix GO:0031012 9.72 VEGFA TIMP2 MMP8 MMP13 MMP1
4 tertiary granule lumen GO:1904724 9.58 TIMP2 OSCAR MMP8
5 platelet alpha granule lumen GO:0031093 9.56 VEGFA PDGFB EGF ALB
6 extracellular region GO:0005576 9.5 VEGFA TTR TNF TIMP2 PDGFB OSCAR
7 specific granule lumen GO:0035580 9.46 TIMP2 OSCAR MMP8 ELANE

Biological processes related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 10.02 TTR TIMP2 OSCAR MMP8 ELANE
2 positive regulation of gene expression GO:0010628 9.93 VEGFA TNF PDGFB MMP8 EGF CRP
3 cellular protein metabolic process GO:0044267 9.91 TTR MMP13 MMP1 ALB
4 negative regulation of gene expression GO:0010629 9.91 VEGFA TNF PDGFB MMP8 FGF2
5 MAPK cascade GO:0000165 9.88 TNF PDGFB FGF7 FGF2 EGF
6 platelet degranulation GO:0002576 9.8 VEGFA PDGFB EGF ALB
7 positive regulation of protein kinase B signaling GO:0051897 9.8 TNF PDGFB FGF7 FGF2 EGF
8 positive regulation of endothelial cell proliferation GO:0001938 9.78 VEGFA PDGFB FGF2
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 TNF PDGFB ELANE
10 positive regulation of protein complex assembly GO:0031334 9.75 VEGFA TNF MMP1
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.74 TNF PDGFB FGF2
12 positive regulation of blood vessel endothelial cell migration GO:0043536 9.73 VEGFA PDGFB FGF2
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 VEGFA PDGFB FGF7 EGF
14 collagen catabolic process GO:0030574 9.72 MMP8 MMP13 MMP1
15 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.7 TNF PDGFB FGF2
16 positive chemotaxis GO:0050918 9.67 VEGFA PDGFB FGF7 FGF2
17 positive regulation of MAPK cascade GO:0043410 9.65 TIMP2 PDGFB MMP8 FGF2 EGF
18 positive regulation of neuroinflammatory response GO:0150078 9.63 TNF MMP8
19 negative regulation of lipid storage GO:0010888 9.62 TNF CRP
20 positive regulation of cell division GO:0051781 9.62 VEGFA PDGFB FGF7 FGF2
21 endothelial cell chemotaxis GO:0035767 9.6 VEGFA PLEKHG5
22 paracrine signaling GO:0038001 9.58 PDGFB FGF2
23 extracellular matrix disassembly GO:0022617 9.55 TIMP2 MMP8 MMP13 MMP1 ELANE
24 positive regulation of hyaluronan biosynthetic process GO:1900127 9.54 PDGFB EGF
25 extracellular matrix organization GO:0030198 9.5 TTR TNF PDGFB MMP8 MMP13 MMP1
26 positive regulation of MAP kinase activity GO:0043406 9.1 VEGFA TNF PDGFB FGF2 ELANE EGF

Molecular functions related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.87 VEGFA TTR TNF PDGFB FGF2 CRP
2 heparin binding GO:0008201 9.56 VEGFA FGF7 FGF2 ELANE
3 endopeptidase activity GO:0004175 9.46 MMP8 MMP13 MMP1 ELANE
4 growth factor activity GO:0008083 9.35 VEGFA PDGFB FGF7 FGF2 EGF
5 chemoattractant activity GO:0042056 8.92 VEGFA PDGFB FGF7 FGF2
Sources

Sources for Chronic Ulcer of Skin

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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