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MCID: CHR100
MIFTS: 53

Chronic Ulcer of Skin

Categories: Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Chronic Ulcer of Skin

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MalaCards integrated aliases for Chronic Ulcer of Skin:

Name: Chronic Ulcer of Skin 42 39 12 15 17
Chronic Wounds 42 64
Indolent Ulcer 12
Callous Ulcer 12
Chronic Ulcer 74

Classifications:

MalaCards categories:
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8549
ICD9CM 36 707
SNOMED-CT 69 19429009
ICD10 34 L98.4
Sources

Summaries for Chronic Ulcer of Skin

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PubMed Health : 64 About chronic wounds: Minor injuries to our skin usually heal quite quickly on their own. Larger wounds may need more time, and sometimes stitches are needed. But some wounds close very slowly, keep on opening up, or do not heal at all. This is often a result of circulation problems or diabetes. Poorly healing wounds are more common on the lower legs or feet. Doctors refer to a wound that that does not heal for a long time as a chronic wound. Treatment often takes a long time and can be very painful. But it is important to have good wound care and to treat the underlying condition that caused the chronic wound to develop.

MalaCards based summary : Chronic Ulcer of Skin, also known as chronic wounds, is related to burns and decubitus ulcer. An important gene associated with Chronic Ulcer of Skin is FGF2 (Fibroblast Growth Factor 2), and among its related pathways/superpathways are Pathways in cancer and Degradation of the extracellular matrix. The drugs Polihexanide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are homeostasis/metabolism and neoplasm

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Related Diseases for Chronic Ulcer of Skin

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Diseases related to Chronic Ulcer of Skin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 burns 30.5 ALB TTR
2 decubitus ulcer 30.0 ALB BSN COPS2 FGF2 SETD2 TTR
3 pyoderma gangrenosum 11.3
4 ulcer of lower limbs 11.0
5 diffuse glomerulonephritis 10.3 ALB FGF2
6 pasteurellosis 10.3 ALB ELANE
7 capillary leak syndrome 10.3 ALB ELANE
8 periodontitis, chronic 10.3 MMP1 MMP8
9 tendinopathy 10.3 MMP1 MMP8
10 ligneous conjunctivitis 10.2 ELANE TTR
11 paramyloidosis 10.2 ALB TTR
12 peptic ulcer perforation 10.2 ALB ELANE
13 marasmus 10.2 ALB TTR
14 vitreous disease 10.2 FGF2 PDGFB
15 kwashiorkor 10.2 ALB TTR
16 aleutian mink disease 10.2 ALB TTR
17 thyroid crisis 10.2 ALB TTR
18 hyperthyroxinemia 10.2 ALB TTR
19 pelvic organ prolapse 10.2 MMP1 MMP8
20 blind loop syndrome 10.2 ALB TTR
21 autonomic nervous system disease 10.2 ALB TTR
22 alpha-1-antitrypsin deficiency 10.2 ALB ELANE
23 epidermolysis bullosa 10.1
24 analbuminemia 10.1 ALB TTR
25 dysentery 10.1 ALB TTR
26 hennekam syndrome 10.1 ALB EGF
27 gingival disease 10.1 ELANE MMP1 MMP8
28 aortic aneurysm, familial abdominal, 1 10.1 ELANE MMP1 MMP8
29 protein-energy malnutrition 10.1 ALB TTR
30 pulmonary emphysema 10.1 ELANE MMP1 MMP8
31 periodontal disease 10.1 ELANE MMP1 MMP8
32 gingival overgrowth 10.1 FGF2 MMP1 PDGFB
33 respiratory failure 10.1 ALB ELANE TTR
34 diabetic foot ulcers 10.1
35 proteasome-associated autoinflammatory syndrome 1 10.0 ALB ELANE SETD2
36 gastric ulcer 10.0 EGF FGF2
37 demyelinating polyneuropathy 10.0 ALB TTR
38 adamantinoma of long bones 10.0 EGF FGF2 MMP1
39 testicular yolk sac tumor 9.9 ALB TTR
40 diabetes mellitus 9.9
41 hypoxia 9.9
42 pulmonary fibrosis, idiopathic 9.9 ELANE FGF2 MMP1 PDGFB
43 squamous cell carcinoma, head and neck 9.9 EGF FGF2 MMP1
44 recessive dystrophic epidermolysis bullosa 9.9
45 vascular disease 9.9
46 pyoderma 9.9
47 ewing sarcoma 9.8 ALB FGF2 MMP1 PDGFB
48 lymphedema 9.8
49 chronic venous insufficiency 9.8
50 venous insufficiency 9.8

Comorbidity relations with Chronic Ulcer of Skin via Phenotypic Disease Network (PDN): (show all 11)


Active Peptic Ulcer Disease Acute Cystitis
Decubitus Ulcer Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Ischemic Heart Disease
Peripheral Vascular Disease Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Chronic Ulcer of Skin:



Diseases related to Chronic Ulcer of Skin
Sources

Symptoms & Phenotypes for Chronic Ulcer of Skin

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MGI Mouse Phenotypes related to Chronic Ulcer of Skin:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.76 ALB ELANE FGF2 MMP1 MMP8 PDGFB
2 neoplasm MP:0002006 9.43 ALB ELANE FGF2 MMP1 MMP8 SETD2
3 vision/eye MP:0005391 9.02 BSN EGF FGF2 PDGFB TTR
Sources

Drugs & Therapeutics for Chronic Ulcer of Skin

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PubMedHealth treatment related to Chronic Ulcer of Skin: 64

Chronic wounds are covered with a dressing for protection. There are other treatment options in addition to regularly changing the wound dressing: Cleaning the wound Medical staff will change the wound dressing and clean the wound regularly. The wound is normally rinsed with a saline or electrolyte solution, or simply with tap water. A technique called debridement is used to remove dead cells or inflamed tissue with tweezers. Having a wound cleaned is often painful. A topical anesthetic such as a medicated ointment can be applied to the wound area to prevent pain. Larger wounds are sometimes cleaned under general anesthetic. Wound dressings After cleaning the wound, the doctor or nurse will put on a new dressing. Things like wet compresses, films or hydrogels are used as wound dressings. Their main purpose is to keep the wound moist, absorb excess fluid and prevent infection. Advanced treatments Some hospitals also use more advanced methods to help especially difficult wounds to heal: In hyperbaric oxygen therapy, patients sit in a special pressurized chamber and breathe in oxygen. In vacuum-assisted closure (VAC therapy), fluid is continuously drawn out of the wound. Ultrasound therapy uses sound waves to treat chronic wounds. Electromagnetic therapy involves the use of magnetic cushions or mats that produce weak electric currents near the wound. Skin grafts Skin grafts may be an option for people with wounds that are too large to close on their own. The surgeon takes skin from another part of the body, often the upper leg, and transplants it to the wound. Grafts can also be made from human cell products and synthetic materials. Medication Good pain management is an important part of wound care. The pain caused by chronic wounds is often underestimated. Painkillers like acetaminophen (paracetamol) or ibuprofen tablets can help relieve mild to moderate pain. Your doctor can prescribe stronger painkillers if these do not provide enough relief. Wound dressings that contain ibuprofen are also available. Antibiotics can be used to treat wounds infected with bacteria.

Drugs for Chronic Ulcer of Skin (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 158)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 28757-47-3
2
Coal tar Approved Phase 4,Not Applicable 8007-45-2
3
Betaine Approved, Nutraceutical Phase 4,Not Applicable 107-43-7 247
4 Octenidine Investigational Phase 4,Not Applicable 71251-02-0
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 Carboxymethylcellulose Sodium Phase 4,Phase 3,Not Applicable
7 Laxatives Phase 4,Phase 3,Not Applicable
8 Cathartics Phase 4,Phase 3,Not Applicable
9 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
10 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
11 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Anti-Infective Agents, Local Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
13 Pulmonary Surfactants Phase 4,Not Applicable
14 Benzalkonium Compounds Phase 4
15
Morphine Approved, Investigational Phase 3,Not Applicable 57-27-2 5288826
16
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
17
Povidone Approved Phase 3,Not Applicable 9003-39-8
18
Iodine Approved, Investigational Phase 3,Phase 2,Not Applicable 7553-56-2 807
19
Povidone-iodine Approved Phase 3,Not Applicable 25655-41-8
20
Metronidazole Approved Phase 3 443-48-1 4173
21
Becaplermin Approved, Investigational Phase 3,Phase 1 165101-51-9
22 Analgesics Phase 3,Phase 1,Phase 2,Not Applicable
23 Analgesics, Opioid Phase 3,Not Applicable
24 Central Nervous System Depressants Phase 3,Not Applicable
25 Peripheral Nervous System Agents Phase 3,Phase 1,Phase 2,Not Applicable
26 Narcotics Phase 3,Not Applicable
27 Micronutrients Phase 2, Phase 3,Phase 3
28 Nutrients Phase 2, Phase 3,Phase 3
29 Trace Elements Phase 2, Phase 3,Phase 3
30 cadexomer iodine Phase 3,Phase 2,Not Applicable
31 Plasma Substitutes Phase 3
32 Blood Substitutes Phase 3
33 Antiprotozoal Agents Phase 3,Phase 2
34 Antiparasitic Agents Phase 3,Phase 2
35 Disinfectants Phase 3,Phase 2,Not Applicable
36 Biguanides Phase 3,Phase 2,Not Applicable
37 Hypoglycemic Agents Phase 3,Phase 2
38
protease inhibitors Phase 3,Not Applicable
39 Angiogenesis Inducing Agents Phase 3,Phase 1
40 HIV Protease Inhibitors Phase 3,Not Applicable
41 Anticoagulants Phase 3,Phase 1
42 Mitogens Phase 3,Phase 2,Phase 1,Not Applicable
43 Angiogenesis Modulating Agents Phase 3
44 Antiviral Agents Phase 3
45 Anti-Retroviral Agents Phase 3
46 Anti-HIV Agents Phase 3
47
Ethanol Approved Phase 1, Phase 2,Not Applicable 64-17-5 702
48
Petrolatum Approved, Investigational Phase 1, Phase 2,Not Applicable 8009-03-8
49
Pirfenidone Approved, Investigational Phase 1, Phase 2 53179-13-8 40632
50
leucovorin Approved Phase 2 58-05-9 6006 143

Interventional clinical trials:

(show top 50) (show all 252)
# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of the SNaP Wound Care System Unknown status NCT01113658 Phase 4
2 The Effect on an Ionic Silver Dressing in Head and Neck Patients With Malignant Fungating Wound Unknown status NCT00813631 Phase 4
3 Evaluation of the Use of EZCareâ—Š in the Management of Acute and Chronic Wounds Completed NCT00994162 Phase 4
4 Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers Completed NCT00621608 Phase 4
5 Comparing Outcomes for Prontosan Versus Normal Saline for Negative Pressure Wound Therapy With Instillation Completed NCT01939145 Phase 4 Normal saline
6 Use of Pulsed Electromagnetic Fields (PEMF) After Breast Reconstruction Surgery Completed NCT01262599 Phase 4
7 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
8 Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds Recruiting NCT03686904 Phase 4 Benzalkonium Gel;benzalkonium irrigation
9 Prontosan Quality of Life Study in Patients With Chronic Leg Wound(s) Recruiting NCT03369756 Phase 4
10 GrafixPL PRIME Evaluation Case Study Recruiting NCT03742440 Phase 4
11 Prophylactic Application of an Incisional Wound Vac to Prevent Wound Complications in Obese Spine Surgery Patients Recruiting NCT02926924 Phase 4
12 Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular Ulcers Not yet recruiting NCT03667937 Phase 4
13 Study to Evaluate the Efficacy of Octenisept® in Patients With Chronic Wounds Terminated NCT01434914 Phase 4 octenisept®;Placebo
14 RESPOND Restoring Equilibrium and Wound Stimulation to Promote Healing Of Non-healing DFUs Terminated NCT01608776 Phase 4
15 Effectiveness of Aurix Therapy in Venous Leg Ulcers Withdrawn NCT02940587 Phase 4
16 A Randomized Comparison of AmnioClearâ„¢ Human Allograft Amniotic Membrane vs. Moist Wound Dressing in the Treatment of Diabetic Wounds Withdrawn NCT02120755 Phase 4
17 MIST Therapy's Effectiveness in Wound Bed Preparation and Role of Bacterial Biofilm in Chronic, Non-healing Wounds Withdrawn NCT01125735 Phase 4
18 A Post-Marketing Clinical Study of Apligraf for Venous Leg Ulcers Withdrawn NCT00648674 Phase 4
19 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
20 An Investigation to Evaluate the Function of a New Silicon Cover Film and an On-top Suction Device to be Used in a NPWT System in the Treatment of Acute and Chronic Wounds Completed NCT01286857 Phase 2, Phase 3
21 Evaluation of a Medical Food for Chronic Wounds Completed NCT00711217 Phase 3
22 Defocused Shock Wave Therapy for Chronic Wounds Completed NCT02410447 Phase 3
23 Efficacy of Prontosan Solution on Chronic Ulcers Completed NCT01333670 Phase 3 Isotonic solution (saline or lactated ringer)
24 Study to Evaluate the Performance of AQUACEL® Extraâ„¢ in Venous Leg Ulcers Completed NCT01591434 Phase 3
25 Rationale for New Topical Anthroponotic Cutaneous Leishmaniasis (ACL) Treatment in Kabul Completed NCT00947362 Phase 2, Phase 3 DAC N-055;saline
26 Honey Versus Povidone-iodine on Laceration Wounds Completed NCT03641053 Phase 3
27 Odor Management in Fungating Wounds Comparing Metronidazole and Polihexanide Completed NCT02394821 Phase 3 Polihexanide 2%;Metronidazole 0.8%
28 Pivotal Trial of Dermagraft(R) to Treat Venous Leg Ulcers Completed NCT00909870 Phase 3
29 A Comparative Study of the Healing of Chronic Ulcers of Recessive Epidermolysis Bullosa : Dressing vs Amniotic Membrane Recruiting NCT02286427 Phase 3
30 Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing Not yet recruiting NCT02845466 Phase 3
31 Non-inferiority Clinic of Kollagenase® Compared Iruxol® in Treatment of Cutaneous Ulcers Suspended NCT00701974 Phase 2, Phase 3
32 Efficacy of Topical Morphine in the Treatment of Severe Local Pain of Chronic Wounds Terminated NCT02028923 Phase 3 Morphine gel
33 A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing Terminated NCT01749306 Phase 3
34 Adipose Derived Regenerative Cellular Therapy of Chronic Wounds Unknown status NCT02092870 Phase 2 Adipose derived stem cells
35 Effect of SACCHACHITIN on Healing of a Chronic Wound Unknown status NCT00117364 Phase 2 SACCHACHITIN patch
36 Study Assessing Safety and Efficacy of B-cure Laser Treating Diabetic Chronic Wounds Unknown status NCT01493895 Phase 1, Phase 2
37 Safety and Efficacy of Topical AR/101 Compared With Placebo, in Accelerating Granulation Tissue Formation of Hard-to-heal Wounds Unknown status NCT02839226 Phase 2 AR/101;Placebo
38 SDF1 Plasmid Treatment for Patients With Peripheral Artery Disease Unknown status NCT02544204 Phase 2
39 The Effectiveness of Topical Silver Colloid in Treating Patients With Recalcitrant Chronic Rhinosinusitis Unknown status NCT02403479 Phase 1, Phase 2 Topical silver colloid
40 Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers Completed NCT02632877 Phase 1, Phase 2 Pirfenidone with MODD;Ketanserin
41 Evaluation of a Ionic Silver and Honey Preparation to Treat Chronic Wounds of the Lower Legs Completed NCT01111695 Phase 2
42 Oleogel-S10 in Wound Healing of Inherited Epidermolysis Bullosa (BEB-10) Completed NCT01294241 Phase 2 Oleogel-S10
43 Evaluation of DermStream(tm) - an Irrigation Product for Chronic Wound Management Completed NCT00310752 Phase 1, Phase 2
44 Reference Nurse Program for Pressure Ulcers in Primary Care Completed NCT01877681 Phase 2
45 SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds Completed NCT00951080 Phase 2
46 Extracorporeal Shockwave Treatment for Chronic Soft Tissue Wounds Completed NCT00545896 Phase 2
47 Autologous Bone Marrow Stem Cells in Pressure Ulcer Treatment Completed NCT01572376 Phase 1, Phase 2
48 Prospective Randomized Double Blind Clinical Trial of Polyhexamethylene Biguanide Impregnated Foam Dressing Completed NCT00618787 Phase 2
49 The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa Completed NCT00380640 Phase 2 Trimethoprim;Trimethoprim
50 Efficacy Study of IZN-6D4 Gel for the Treatment of Diabetic Foot Ulcers Completed NCT01427569 Phase 2 IZN-6D4 Gel

Search NIH Clinical Center for Chronic Ulcer of Skin

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Ulcer of Skin cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Ulcer of Skin:
EpiDex�, follicular keratinocyte sheets for treatment of chronic wounds
Grafix�, mesenchymal stem cells for wound healing
Myskin�, keratinocytes on a polymer film patch for treatment of skin ulcers
Embryonic/Adult Cultured Cells Related to Chronic Ulcer of Skin:
Epidermal keratinocytes (EpiDex�) PMIDs: 21071921 12846911 19538195
MSC-containing human skin substitute (Grafix) PMIDs: 23197761
Keratinocytes on a polymer film (Myskin�) PMIDs: 18034628
Sources

Genetic Tests for Chronic Ulcer of Skin

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Sources

Anatomical Context for Chronic Ulcer of Skin

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MalaCards organs/tissues related to Chronic Ulcer of Skin:

42
Skin, Bone, Testes, Colon, Bone Marrow, Eye, Breast
Sources

Publications for Chronic Ulcer of Skin

About this section

Articles related to Chronic Ulcer of Skin:

(show top 50) (show all 853)
# Title Authors Year
1
Rothmund-Thomson syndrome type 2 - a rare cause of chronic wounds. ( 30821407 )
2019
2
Use of platelet-rich plasma and platelet-derived patches to treat chronic wounds. ( 30625042 )
2019
3
A change in the prevalence and the etiological factors of chronic wounds in Helsinki metropolitan area during 2008-2016. ( 30672095 )
2019
4
3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds. ( 30797865 )
2019
5
Cost-effectiveness analysis of an innovative model of care for chronic wounds patients. ( 30840658 )
2019
6
In-situ doping of a conductive hydrogel with low protein absorption and bacterial adhesion for electrical stimulation of chronic wounds. ( 30862548 )
2019
7
Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth,not virulence or biofilm functions. ( 30893371 )
2019
8
Digital Education for the Management of Chronic Wounds in Health Care Professionals: Protocol for a Systematic Review by the Digital Health Education Collaboration. ( 30907743 )
2019
9
Nanofiber Dressings Topically Delivering Molecularly Engineered Human Cathelicidin Peptides for Treatment of Biofilms in Chronic Wounds. ( 30916573 )
2019
10
Multiphotonic staging of chronic wounds and evaluation of sterile, optical transparent bacterial nanocellulose covering: A diagnostic window into human skin. ( 29923636 )
2019
11
The humanistic and economic burden of chronic wounds: A systematic review. ( 30362646 )
2019
12
Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies. ( 30497932 )
2019
13
Type I collagen peptides and nitric oxide releasing electrospun silk fibroin scaffold: A multifunctional approach for the treatment of ischemic chronic wounds. ( 30583219 )
2019
14
In situ gelation of rhEGF-containing liquid crystalline precursor with good cargo stability and system mechanical properties: a novel delivery system for chronic wounds treatment. ( 30603758 )
2019
15
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438151 )
2018
16
Identifying Pain and Effects on Quality of Life from Chronic Wounds Secondary to Lower-Extremity Vascular Disease: An Integrative Review. ( 29438143 )
2018
17
Contact dermatitis caused by dialkylcarbamoyl compounds in a medication used for chronic wounds. ( 29761496 )
2018
18
Author Correction: Synergistic effect of human Bone Morphogenic Protein-2 and Mesenchymal Stromal Cells on chronic wounds through hypoxia-inducible factor-1 α induction. ( 29643419 )
2018
19
Chronic Wounds: Innovations in Diagnostics and Therapeutics. ( 28699502 )
2018
20
Production of platelet-rich plasma gel from elderly patients under antithrombotic drugs: Perspectives in chronic wounds care. ( 28805478 )
2018
21
Segmentation and Measurement of Chronic Wounds for Bioprinting. ( 28841560 )
2018
22
Need for Improved Definition of "Chronic Wounds" in Clinical Studies. ( 28880344 )
2018
23
The inter-rater reliability between nurse-assessors clinically assessing infection of chronic wounds using the WUWHS criteria. ( 29076279 )
2018
24
Wound Care Center of Excellence: Guide to Operative Technique for Chronic Wounds. ( 29154922 )
2018
25
Descriptors for Itch Related to Chronic Wounds. ( 29406292 )
2018
26
Hyperbaric oxygen therapy and intermittent ischaemia in the treatment of chronic wounds. ( 29417747 )
2018
27
A histological analysis of chronic wounds treated with negative pressure wound therapy to aid healing: a case series. ( 29419368 )
2018
28
Assessment of Function after Free Tissue Transfer to the Lower Extremity for Chronic Wounds Using the Lower Extremity Functional Scale. ( 29452439 )
2018
29
New techniques for wound management: A systematic review of their role in the management of chronic wounds. ( 29506339 )
2018
30
Using a modified Delphi methodology to gain consensus on the use of dressings in chronic wounds management. ( 29509111 )
2018
31
Clinical Assessment of a Biofilm-disrupting Agent for the Management of Chronic Wounds Compared With Standard of Care: A Therapeutic Approach. ( 29521641 )
2018
32
When and How to Perform Cultures on Chronic Wounds? ( 29521930 )
2018
33
Ozone therapy for the treatment of chronic wounds: A systematic review. ( 29536625 )
2018
34
Local warming therapy for treating chronic wounds: A systematic review. ( 29561463 )
2018
35
A Scoping Review of the Use of Silver-impregnated Dressings for the Treatment of Chronic Wounds. ( 29584609 )
2018
36
Xanthine Oxidoreductase: A Novel Therapeutic Target for the Treatment of Chronic Wounds? ( 29644146 )
2018
37
Phototherapy with LED Shows Promising Results in Healing Chronic Wounds in Diabetes Mellitus Patients: A Prospective Randomized Double-Blind Study. ( 29668397 )
2018
38
Bromelain-based enzymatic debridement of chronic wounds: A preliminary report. ( 29696785 )
2018
39
A Post-marketing Surveillance Study of Chronic Wounds Treated With a Native Collagen Calcium Alginate Dressing. ( 29718816 )
2018
40
The impact of ethanol extract of propolis on biofilm forming by Proteus Mirabilis strains isolated from chronic wounds infections. ( 29726711 )
2018
41
Silver absorption and toxicity evaluation of silver wound dressings in 40 patients with chronic wounds. ( 29730878 )
2018
42
Conflict over the need for evidence when choosing dressings for chronic wounds. ( 29738304 )
2018
43
Effects of Low-Power Light Therapy on the Tissue Repair Process of Chronic Wounds in Diabetic Feet. ( 29882738 )
2018
44
Barriers and enablers to patient recruitment for randomised controlled trials on treatment of chronic wounds: A systematic review. ( 29927054 )
2018
45
Assessment of chronic wounds in adults: an integrative review. ( 29947700 )
2018
46
Smart Wound Dressings for Diabetic Chronic Wounds. ( 29949930 )
2018
47
Economic Evaluations of Guideline-Based Care for Chronic Wounds: a Systematic Review. ( 29968020 )
2018
48
Medical Devices; General and Plastic Surgery Devices; Classification of the Extracorporeal Shock Wave Device for Treatment of Chronic Wounds. Final order. ( 29969205 )
2018
49
Monitoring and Molecular Characterization of Staphylococcus aureus Isolated from Chronic Wounds. ( 29975199 )
2018
50
Smart Bandage for Monitoring and Treatment of Chronic Wounds. ( 29978547 )
2018
Sources

Variations for Chronic Ulcer of Skin

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Sources

Expression for Chronic Ulcer of Skin

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Search GEO for disease gene expression data for Chronic Ulcer of Skin.
Sources

Pathways for Chronic Ulcer of Skin

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Pathways related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 38
12.48 EGF FGF2 MMP1 PDGFB
2
Degradation of the extracellular matrix 67
Show member pathways
 11.75 ELANE FGF2 MMP1 MMP8 PDGFB TTR
3
Matrix Metalloproteinases 1
Show member pathways
 11.58 ELANE MMP1 MMP8
4
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.44 EGF FGF2 PDGFB
5
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.38 ALB EGF FGF2 PDGFB
6
Lung fibrosis 1
11.3 EGF FGF2 PDGFB
7
FOXA2 and FOXA3 transcription factor networks 1
11.14 ALB TTR
8
Differentiation Pathway 1
11.11 EGF FGF2 PDGFB
9
Cell adhesion_Cell-matrix glycoconjugates 23
11.07 ELANE MMP1
10
Vemurafenib Pathway, Pharmacodynamics 62
10.97 EGF FGF2 PDGFB
11
Angiogenesis (WikiPathways) 1
10.81 FGF2 PDGFB
Sources

GO Terms for Chronic Ulcer of Skin

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Cellular components related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB EGF ELANE FGF2 MMP8 PDGFB
2 platelet alpha granule lumen GO:0031093 9.33 ALB EGF PDGFB
3 extracellular region GO:0005576 9.23 ALB EGF ELANE FGF2 MMP1 MMP8

Biological processes related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.76 EGF FGF2 SETD2
2 MAPK cascade GO:0000165 9.73 EGF FGF2 PDGFB
3 cellular protein metabolic process GO:0044267 9.72 ALB MMP1 TTR
4 extracellular matrix organization GO:0030198 9.71 FGF2 PDGFB TTR
5 peptidyl-tyrosine phosphorylation GO:0018108 9.63 EGF FGF2 PDGFB
6 positive regulation of protein kinase B signaling GO:0051897 9.61 EGF FGF2 PDGFB
7 positive regulation of protein tyrosine kinase activity GO:0061098 9.58 EGF PDGFB
8 collagen catabolic process GO:0030574 9.57 MMP1 MMP8
9 platelet degranulation GO:0002576 9.54 ALB EGF PDGFB
10 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.52 FGF2 PDGFB
11 positive regulation of DNA binding GO:0043388 9.51 EGF MMP8
12 phosphatidylinositol phosphorylation GO:0046854 9.5 EGF FGF2 PDGFB
13 endodermal cell differentiation GO:0035987 9.49 MMP8 SETD2
14 positive regulation of mitotic nuclear division GO:0045840 9.48 EGF PDGFB
15 positive regulation of DNA biosynthetic process GO:2000573 9.4 FGF2 PDGFB
16 extracellular matrix disassembly GO:0022617 9.33 ELANE MMP1 MMP8
17 paracrine signaling GO:0038001 9.26 FGF2 PDGFB
18 positive regulation of hyaluronan biosynthetic process GO:1900127 8.96 EGF PDGFB
19 positive regulation of MAP kinase activity GO:0043406 8.92 EGF ELANE FGF2 PDGFB

Molecular functions related to Chronic Ulcer of Skin according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.54 ELANE MMP1 MMP8
2 growth factor activity GO:0008083 9.43 EGF FGF2 PDGFB
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 EGF FGF2 PDGFB
4 chemoattractant activity GO:0042056 9.32 FGF2 PDGFB
5 endopeptidase activity GO:0004175 9.13 ELANE MMP1 MMP8
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 8.8 EGF FGF2 PDGFB
Sources

Sources for Chronic Ulcer of Skin

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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