MCID: CHR431
MIFTS: 48

Chronic Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Chronic Venous Insufficiency

MalaCards integrated aliases for Chronic Venous Insufficiency:

Name: Chronic Venous Insufficiency 12 54 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0050853
UMLS 70 C1306557

Summaries for Chronic Venous Insufficiency

Disease Ontology : 12 A venous insufficiency that is characterized by lower extremity swelling, hyperpigmentation, pruritus and venous ulceration caused by blood pooling in the veins.

MalaCards based summary : Chronic Venous Insufficiency is related to post-thrombotic syndrome and thrombophilia due to thrombin defect. An important gene associated with Chronic Venous Insufficiency is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Hesperidin and Coumarin have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining... more...

Related Diseases for Chronic Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Chronic Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 403)
# Related Disease Score Top Affiliating Genes
1 post-thrombotic syndrome 30.8 VCAM1 SERPINE1 ICAM1 F2
2 thrombophilia due to thrombin defect 30.4 SERPINE1 PLAT MTHFR F2
3 lipodermatosclerosis 30.3 VEGFA TIMP2 PLAT MMP1
4 amaurosis fugax 30.2 SERPINE1 MTHFR MMP9
5 thrombophlebitis 30.1 SERPINE1 PLAT MTHFR F2 CRP
6 thrombosis 30.1 SERPINE1 SELP PLAT MTHFR F2
7 hemorrhoid 30.1 MMP9 F2 CRP
8 intracranial hypertension 30.1 SERPINE1 MTHFR F2
9 arteriosclerosis obliterans 30.1 VCAM1 SELP ICAM1
10 thrombophilia 30.0 SERPINE1 SELP PLAT MTHFR F2
11 relapsing-remitting multiple sclerosis 30.0 TIMP1 MMP9 ITGA4 ICAM1
12 sickle cell disease 30.0 VCAM1 SELP SELL
13 contact dermatitis 29.9 VCAM1 SELL ICAM1
14 allergic contact dermatitis 29.9 VCAM1 SELL ICAM1
15 pulmonary embolism 29.8 SERPINE1 PLAT MTHFR F2 CRP
16 homocysteinemia 29.8 VCAM1 SERPINE1 MTHFR F2 CRP
17 pyoderma 29.6 MMP9 MMP1 CRP
18 arteries, anomalies of 29.6 VEGFA VCAM1 SERPINE1 ICAM1 CRP
19 buerger disease 29.6 VEGFA VCAM1 ICAM1 CRP
20 peripheral artery disease 29.5 VEGFA VCAM1 SELP ICAM1 CRP
21 body mass index quantitative trait locus 11 29.5 VEGFA VCAM1 SERPINE1 SELL ICAM1 CRP
22 varicose veins 29.5 VEGFA TIMP2 TIMP1 PLAT MTHFR MMP9
23 skin disease 29.4 VEGFA SELL MMP1 ITGAL ICAM1 CRP
24 primary progressive multiple sclerosis 29.4 VCAM1 TIMP1 SELL MMP9 ITGAL ITGA4
25 proteasome-associated autoinflammatory syndrome 1 29.4 VCAM1 SELP SELL MMP9 ICAM1 CRP
26 intermittent claudication 29.3 VEGFA SERPINE1 SELP F2 CRP
27 venous insufficiency 29.3 VEGFA VCAM1 TIMP1 SERPINE1 SELP SELL
28 chronic ulcer of skin 29.2 VEGFA TIMP2 MMP9 MMP1 CRP
29 tetralogy of fallot 29.2 VEGFA MTHFR MMP9 CRP
30 vasculitis 29.1 VCAM1 SELP SELL ITGAM ITGA4 ICAM1
31 vein disease 29.0 VEGFA SERPINE1 SELP PLAT MTHFR ICAM1
32 arteriosclerosis 29.0 VCAM1 TIMP1 SERPINE1 SELP MMP9 ICAM1
33 peripheral vascular disease 28.7 VEGFA VCAM1 TIMP1 SERPINE1 SELP PLAT
34 vascular disease 28.4 VEGFA VCAM1 TIMP1 SERPINE1 SELP PLAT
35 melanoma 28.3 VEGFA TIMP2 TIMP1 PLAT MMP9 MMP1
36 cerebrovascular disease 28.1 VCAM1 SERPINE1 SELP SELL PLAT MTHFR
37 diabetes mellitus 27.2 VEGFA VCAM1 TIMP1 SERPINE1 SELP SELL
38 heart disease 26.3 VEGFA VCAM1 TIMP2 TIMP1 SERPINE1 SELP
39 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
40 dermatitis 10.5
41 dowling-degos disease 1 10.5
42 neonatal stroke 10.4 SERPINE1 MTHFR
43 intracranial arteriosclerosis 10.4 SERPINE1 SELP
44 autoimmune inner ear disease 10.3 TIMP1 MMP9
45 hereditary lymphedema i 10.3
46 toxicodendron dermatitis 10.3 SELL ICAM1
47 catastrophic antiphospholipid syndrome 10.3 SERPINE1 MTHFR
48 arteritic anterior ischemic optic neuropathy 10.3 MTHFR F2
49 lentigo maligna melanoma 10.3 TIMP1 MMP9
50 autoimmune enteropathy 10.3 ITGAL ICAM1

Graphical network of the top 20 diseases related to Chronic Venous Insufficiency:



Diseases related to Chronic Venous Insufficiency

Symptoms & Phenotypes for Chronic Venous Insufficiency

MGI Mouse Phenotypes related to Chronic Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CRP F2 ICAM1 ITGA4 MMP12 MMP9
2 homeostasis/metabolism MP:0005376 10.3 CRP F2 ICAM1 ITGAL ITGAM MMP1
3 hematopoietic system MP:0005397 10.25 ICAM1 ITGA4 ITGAL ITGAM MMP12 MMP9
4 immune system MP:0005387 10.25 CRP F2 ICAM1 ITGA4 ITGAL ITGAM
5 growth/size/body region MP:0005378 10.21 F2 ICAM1 MMP9 MTHFR PLAT SELL
6 cellular MP:0005384 10.2 F2 ICAM1 ITGA4 ITGAL ITGAM MMP9
7 integument MP:0010771 9.96 F2 ICAM1 MMP12 MMP9 MTHFR PLAT
8 neoplasm MP:0002006 9.76 ICAM1 ITGAL MMP1 MMP9 SELL SERPINE1
9 reproductive system MP:0005389 9.61 F2 MMP12 MMP9 MTHFR PLAT SELL
10 respiratory system MP:0005388 9.28 F2 MMP12 MMP9 PLAT SELL SELP

Drugs & Therapeutics for Chronic Venous Insufficiency

Drugs for Chronic Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Coumarin Experimental Phase 4 91-64-5 323
3
Troxerutin Investigational Phase 4 7085-55-4 5486699
4 Hemostatics Phase 4
5 Anticoagulants Phase 4
6 Salicylates Phase 4
7 Heparinoids Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Coagulants Phase 4
10 Aminaftone Phase 4
11 Anesthetics Phase 4
12
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
13 Tin Fluorides Phase 3
14 Grape Approved Phase 2
15
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
16
Horse chestnut Experimental Phase 2
17
Quercetin Experimental, Investigational Phase 2 117-39-5 5280343
18 Vitamins Phase 2
19 Vitamin B Complex Phase 2
20 Vitamin B 6 Phase 2
21 Calcium, Dietary Phase 2
22 Protective Agents Phase 2
23 Antioxidants Phase 2
24
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050
25
Calcium Nutraceutical Phase 2 7440-70-2 271
26
Epinephrine Approved, Vet_approved 51-43-4 5816
27
Racepinephrine Approved 329-65-7 838
28
Ticlopidine Approved 55142-85-3 5472
29
Pentoxifylline Approved, Investigational 6493-05-6 4740
30
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
31
Aspirin Approved, Vet_approved 50-78-2 2244
32
Chlorhexidine Approved, Vet_approved 55-56-1 2713 9552079
33
Nimesulide Approved, Investigational, Withdrawn 51803-78-2 4495
34
Polidocanol Approved 9002-92-0
35
Heparin Approved, Investigational 9005-49-6 772 9812414
36
Tribenoside Experimental 10310-32-4
37
Monensin Experimental, Vet_approved 17090-79-8
38 Adrenergic alpha-Agonists
39 Vasoconstrictor Agents
40 Adrenergic beta-Agonists
41 Respiratory System Agents
42 Anti-Asthmatic Agents
43 Epinephryl borate
44 Sympathomimetics
45 Adrenergic Agents
46 Mydriatics
47 Neurotransmitter Agents
48 Adrenergic Agonists
49 Bronchodilator Agents
50 Antibiotics, Antitubercular

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
2 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
3 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
4 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
5 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
6 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
7 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
8 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
9 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
10 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
11 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
12 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
13 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
14 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
15 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
16 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
17 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
18 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
19 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
20 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
21 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
22 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
23 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
24 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
25 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
26 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
27 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
28 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
29 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
30 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Active, not recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
31 Study on the Effect of Kinesio Taping on Bioelectrical Activity of Gastrocnemius Muscles and Range of Ankle Motion in Post-menopausal Women With Chronic Venous Insufficiency Completed NCT01501188 Phase 1
32 Phase I Open-label, First-in-human Study to Evaluate Feasibility and Safety of Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
33 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
34 Open Label, Prospective Clinical Trial to Evaluate Impact on Quality of Life in Chronic Venous Insufficiency Patients Using SANKOM® Patent Socks During 4 Weeks Unknown status NCT03445091
35 The Effect of Structured Exercise on Chronic Venous Insufficiency: A Feasibility Trial Unknown status NCT03562546
36 EdemaWear to Reduce Edema in Hospitalized Patients With Chronic Venous Insufficiency: A Pilot Study Unknown status NCT03904602
37 The Clinical Research of Surgery on Primary Chronic Venous Insufficiency Unknown status NCT00931424
38 Prospective Multicentric Randomised Trial Between Radiofrequency Ablation With VNUS Closure Fast ® and Endovenous Ablation With 1470 nm Diod Laser and Tulip Fiber ® for Treatment of Primary Venous Insufficiency. Unknown status NCT01722019
39 Local Endogenous Biomarkers in the Later Stages of Chronic Venous Disease Versus Controls During Gravitational Stress, Prolonged Elevation Recovery and Compression Unknown status NCT02662127
40 Safety and Primary Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Sequel - A Pilot Study Unknown status NCT01346553
41 The Role of Adrenaline in the Reduction of Subcutaneous Ecchymoses and Hematomas and in the Improvement of the Quality of Life of Patients After Classic Great Saphenous Vein Stripping Completed NCT04758728 Epinephrine Topical;normal saline
42 Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort Completed NCT02015221
43 Prevalence of Onychodystrophy in Patients With Chronic Venous Disease of the Lower Limbs Completed NCT02731222
44 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482
45 Cross-Sectional Population Based Study on Prevalence and Risk Factors for Chronic Venous Disease in General Population Completed NCT03900234
46 Prospective Safety and Effectiveness Study: VenaCure Endovenous Laser Treatment (EVLT) 400 µm Fiber Procedure Kit for Treatment of Incompetent Perforator Veins Completed NCT02215369
47 Chronic Venous Insufficiency; Impact of Compression Stockings on Quality of Life Completed NCT02050061
48 Intermittent, Gradient, Pneumatic Compression Plus Standard Compression for Hard-To-Heal Venous Ulcers in Subjects With Secondary Lymphedema and Chronic Venous Insufficiency Completed NCT01079299
49 New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985
50 LivRelief Varicose Veins Cream in the Treatment of Chronic Venous Insufficiency of the Lower Limbs: A 6-week Single Arm Pilot Study Completed NCT03653793

Search NIH Clinical Center for Chronic Venous Insufficiency

Genetic Tests for Chronic Venous Insufficiency

Anatomical Context for Chronic Venous Insufficiency

MalaCards organs/tissues related to Chronic Venous Insufficiency:

40
Skin, Endothelial, Heart, Bone, Neutrophil, Kidney, Bone Marrow

Publications for Chronic Venous Insufficiency

Articles related to Chronic Venous Insufficiency:

(show top 50) (show all 2722)
# Title Authors PMID Year
1
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. 54 61
15191401 2004
2
[Cytochromes P450, vascular tone varicosis]. 54 61
12843956 2003
3
[Changes in VCAM-1 cell adhesion molecule after phlebologic thermal care in chronic venous insufficiency of the lower limbs]. 54 61
11917667 2001
4
Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency. 54 61
10086854 1999
5
Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. 54 61
8609252 1996
6
Endovascular and medical therapy of May-Thurner syndrome: Case series and scoping literature review. 61
33752850 2021
7
Therapeutic potential of flavonoids in the treatment of chronic venous insufficiency. 61
33278582 2021
8
Transmural pressure for conceptualisation of chronic venous insufficiency management. 61
33270505 2021
9
Association between vein diameters, reflux characteristics, and clinical severity in patients with chronic venous insufficiency in Northwest China. 61
32730997 2021
10
Defining the human and health care costs of chronic venous insufficiency. 61
33757637 2021
11
Management of Lower Extremity Pain from Chronic Venous Insufficiency: A Comprehensive Review. 61
33704678 2021
12
Evaluation of physical activity level and exercise capacity in patients with varicose veins and chronic venous insufficiency. 61
33745365 2021
13
Early results of an Asian prospective multicenter VenaSeal real-world postmarket evaluation to investigate the efficacy and safety of cyanoacrylate endovenous ablation for varicose veins. 61
32387378 2021
14
A Case Report on Treatment of Nonhealing Leg Ulcer: Do Not Forget the Underlying Disease. 61
33745332 2021
15
Clinical outcome of short-term compression after sclerotherapy for telangiectatic varicose veins. 61
32502730 2021
16
Prospective comparative study evaluating the role of flavonoids after endovenous thermal ablation. 61
33752526 2021
17
Use of Sponge-Foam Inserts in Compression Bandaging of Non-Healing Venous Leg Ulcers. 61
33786099 2021
18
Mechanochemical ablation for great and small saphenous veins insufficiency in patients with type III shunt. 61
32847473 2021
19
Limitations to self-management of adjustable compression wraps in the elderly: results of a prospective cohort study. 61
33739073 2021
20
Post-thrombotic syndrome - a position paper from European Society of Vascular Medicine. 61
33720757 2021
21
Clinical and hemodynamic outcome of morbidly obese patients with severe chronic venous insufficiency with and without bariatric surgery: A comparative study. 61
33540136 2021
22
[Long-term healing of a therapy-refractory venous leg ulcer after crural fasciectomy and split skin graft transplantation]. 61
32720166 2021
23
Efficacy of Human Recombinant Epidermal Growth Factors vs Conventional Therapy for the Treatment of Chronic Venous Ulcers: A Retrospective Case Series. 61
33591927 2021
24
Predictors for readmission due to cellulitis among Japanese patients. 61
33523517 2021
25
Internal valvuloplasty combined with sleeve wrapping in the treatment of severe deep venous incompetence: A case report. 61
33530885 2021
26
Effect of Pre-Procedure Clopidogrel With Iliac Vein Stenting in Non-Thrombotic Vein Lesions. 61
33602039 2021
27
Comparative efficacy and life quality effects of surgical stripping, radiofrequency ablation, and cyanoacrylate embolization in patients undergoing treatment for great saphenous vein insufficiency. 61
32741257 2021
28
Transabdominal duplex ultrasound and intravascular ultrasound planimetry measures of common iliac vein stenosis are significantly correlated in a symptomatic population. 61
33548556 2021
29
Validity of Chronic Venous Disease Diagnoses and Epidemiology Using Validated Electronic Health Records From Primary Care: A Real-World Data Analysis. 61
33638608 2021
30
Innovative biodegradable dibutyrylchitin dressing for the treatment of ulcers occurring during chronic venous insufficiency in patients with type 2 diabetes. 61
33559646 2021
31
Allergic Contact Dermatitis to VenaSeal After Chronic Venous Insufficiency Treatment Mimics Phlebitis. 61
33443376 2021
32
Randomized clinical trial of radiofrequency-induced thermotherapy combined with transilluminated powered phlebectomy versus high ligation and stripping for the treatment of lower limb varicose veins. 61
32454239 2021
33
Recurrence types 3 years after endovenous thermal ablation in insufficient saphenofemoral junctions. 61
32361003 2021
34
Treatment of superficial venous reflux in CEAP 6 patients: a comparison of cyanoacrylate glue and radiofrequency ablation techniques. 61
33453440 2021
35
Comparison of unilateral vs bilateral and staged bilateral vs concurrent bilateral truncal endovenous ablation in the Vascular Quality Initiative. 61
32470615 2021
36
Utility of Unilateral versus Bilateral Venous Reflux Studies for Venous Insufficiency. 61
33529718 2021
37
Complete Venous Ulceration Healing after Perforator Ablation Does Not Depend on Treatment Modality. 61
32603845 2021
38
Safety and feasibility report on nonimplantable endovenous valve formation for the treatment of deep vein reflux. 61
33359385 2021
39
Examining risk factors and preventive treatments for first venous leg ulceration: A cohort study. 61
31884088 2021
40
ETNA VTE Europe: A contemporary snapshot of patients treated with edoxaban in clinical practice across eight European countries. 61
32826158 2020
41
The skin hyperpigmentation index: An objective method of measuring the intensity of hyperpigmentation after sclerotherapy. 61
32715908 2020
42
Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment. 61
33374372 2020
43
[What is evidence-based in the treatment of chronic venous insufficiency?] 61
33141265 2020
44
Repurposing the systemic venous return model for conceptualisation of chronic venous insufficiency and its management. 61
32525447 2020
45
The Inhibition of Prolyl Oligopeptidase as New Target to Counteract Chronic Venous Insufficiency: Findings in a Mouse Model. 61
33322134 2020
46
Exit site complications following cyanoacrylate glue endovenous ablation of incompetent truncal veins for chronic venous insufficiency. 61
33134630 2020
47
Accuracy of contralateral Villalta score to assess for pre-existing chronic venous insufficiency in patients with unilateral deep vein thrombosis. 61
32898930 2020
48
Investigation of chronic venous insufficiency in patients with sleep disorders due to restless legs syndrome. 61
32664803 2020
49
Prevalence and predictors of alternative diagnoses on whole-leg ultrasound negative for acute deep venous thrombosis. 61
33267839 2020
50
MTR-G is a high-risk allele for lower-extremity arteriosclerotic occlusion. 61
33345688 2020

Variations for Chronic Venous Insufficiency

Expression for Chronic Venous Insufficiency

Search GEO for disease gene expression data for Chronic Venous Insufficiency.

Pathways for Chronic Venous Insufficiency

Pathways related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 VEGFA VCAM1 TIMP2 TIMP1 SELL MMP9
2
Show member pathways
13.68 VEGFA TIMP2 TIMP1 MMP9 MMP12 MMP1
3
Show member pathways
13.51 VEGFA TIMP2 TIMP1 ITGAM ITGAL ITGA4
4
Show member pathways
13.36 VEGFA VCAM1 SERPINE1 MMP9 MMP12 MMP1
5
Show member pathways
13.33 VEGFA VCAM1 TIMP1 MMP9 MMP1 ITGAM
6
Show member pathways
13.22 VEGFA TIMP1 SERPINE1 SELP SELL PLAT
7
Show member pathways
13.16 VCAM1 SERPINE1 SELP MMP9 MMP1 ICAM1
8
Show member pathways
12.64 VEGFA VCAM1 MMP9 ITGAM ITGAL ITGA4
9
Show member pathways
12.37 TIMP2 TIMP1 ITGAM ITGAL ITGA4
10
Show member pathways
12.33 SERPINE1 PLAT MTHFR ICAM1 F2 CRP
11
Show member pathways
12.29 VEGFA TIMP1 SERPINE1 MMP1
12 12.18 VEGFA MMP9 MMP12 MMP1
13
Show member pathways
12.18 VCAM1 ITGAM ITGAL ITGA4 ICAM1
14
Show member pathways
12.16 SELP SELL MMP1 ITGAM ITGAL ITGA4
15 12.12 VEGFA VCAM1 PLAT MMP9 ICAM1
16 12.11 SERPINE1 PLAT ITGAM F2
17 12.1 VCAM1 SELL ITGAL ITGA4 ICAM1
18 12.05 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
19 12.02 SELP MMP9 MMP12 ICAM1
20
Show member pathways
12.02 VCAM1 TIMP2 TIMP1 SERPINE1 MMP9 MMP12
21 11.97 VCAM1 SELP SELL ITGAM ITGAL ITGA4
22
Show member pathways
11.93 TIMP2 TIMP1 MMP9 MMP12 MMP1
23 11.92 VEGFA VCAM1 SERPINE1 ICAM1
24 11.9 SELP ITGAM ITGAL ICAM1
25 11.88 VEGFA MMP1 ITGAL ICAM1
26 11.82 TIMP2 TIMP1 MMP9
27 11.79 ITGAM ITGAL ITGA4
28 11.76 VEGFA VCAM1 TIMP1 MMP9 MMP1 ITGAM
29 11.73 TIMP2 TIMP1 ITGAM ITGAL ITGA4
30 11.72 VEGFA MMP9 MMP1
31 11.72 VCAM1 ITGAL ITGA4 ICAM1
32
Show member pathways
11.69 VEGFA VCAM1 MMP9 MMP1 ICAM1
33 11.66 VEGFA PLAT MMP9
34 11.58 VCAM1 SELP ITGAL ICAM1
35 11.54 SELP PLAT MMP9 ITGAM ICAM1
36
Show member pathways
11.48 VCAM1 ITGAL ITGA4
37 11.47 VCAM1 ITGAM ITGAL ITGA4 ICAM1
38 11.44 TIMP2 SELL MMP9 MMP1
39
Show member pathways
11.29 VEGFA TIMP1 CRP
40 11.29 TIMP2 TIMP1 SERPINE1 PLAT MMP9 MMP12
41 11.18 VEGFA TIMP2 MMP9
42 11.12 TIMP2 TIMP1 MMP9 ICAM1 F2
43 11.06 VEGFA TIMP1 MMP1
44 10.99 TIMP2 TIMP1 ITGAM ITGAL ITGA4
45 10.81 SERPINE1 PLAT

GO Terms for Chronic Venous Insufficiency

Cellular components related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 VEGFA TIMP2 TIMP1 SERPINE1 PLAT MMP9
2 extracellular exosome GO:0070062 10.02 VCAM1 TIMP1 SERPINE1 PLAT MMP9 ITGAM
3 external side of plasma membrane GO:0009897 9.83 VCAM1 SELP ITGAM ICAM1 F2
4 collagen-containing extracellular matrix GO:0062023 9.73 TIMP2 SERPINE1 PLAT MMP9 ICAM1 F2
5 platelet alpha granule lumen GO:0031093 9.63 VEGFA TIMP1 SERPINE1
6 extracellular matrix GO:0031012 9.63 VEGFA TIMP2 TIMP1 MMP9 MMP12 MMP1
7 cell surface GO:0009986 9.56 VEGFA VCAM1 TIMP2 PLAT ITGAM ITGAL
8 integrin complex GO:0008305 9.54 ITGAM ITGAL ITGA4
9 extracellular space GO:0005615 9.44 VEGFA VCAM1 TIMP2 TIMP1 SERPINE1 SELP

Biological processes related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.04 VCAM1 SELP SELL ITGAM ITGAL ITGA4
2 neutrophil degranulation GO:0043312 10.02 TIMP2 SELL MMP9 ITGAM ITGAL
3 regulation of immune response GO:0050776 9.91 VCAM1 SELL ITGAL ITGA4 ICAM1
4 response to hypoxia GO:0001666 9.88 VEGFA VCAM1 PLAT MTHFR ICAM1
5 platelet degranulation GO:0002576 9.86 VEGFA TIMP1 SERPINE1 SELP
6 integrin-mediated signaling pathway GO:0007229 9.81 ITGAM ITGAL ITGA4
7 cell-matrix adhesion GO:0007160 9.81 VCAM1 ITGAL ITGA4
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 VEGFA SELP F2
9 cytokine-mediated signaling pathway GO:0019221 9.8 VEGFA VCAM1 TIMP1 MMP9 MMP1 ITGAM
10 cellular response to amyloid-beta GO:1904646 9.76 VCAM1 ITGA4 ICAM1
11 collagen catabolic process GO:0030574 9.74 MMP9 MMP12 MMP1
12 extracellular matrix disassembly GO:0022617 9.72 TIMP2 TIMP1 MMP9 MMP12 MMP1
13 negative regulation of proteolysis GO:0045861 9.71 TIMP2 PLAT F2
14 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.71 VCAM1 SELP ITGAL ICAM1
15 fibrinolysis GO:0042730 9.7 SERPINE1 PLAT F2
16 leukocyte tethering or rolling GO:0050901 9.67 VCAM1 SELP SELL ITGA4
17 response to amyloid-beta GO:1904645 9.65 MMP9 MMP12
18 positive regulation of blood coagulation GO:0030194 9.64 SERPINE1 F2
19 positive regulation of leukocyte migration GO:0002687 9.63 VEGFA SELP ITGA4
20 negative regulation of fibrinolysis GO:0051918 9.62 SERPINE1 F2
21 negative regulation of metallopeptidase activity GO:1905049 9.61 TIMP2 TIMP1
22 positive regulation of leukocyte tethering or rolling GO:1903238 9.61 SELP ITGA4
23 cellular response to UV-A GO:0071492 9.61 TIMP1 MMP9 MMP1
24 extracellular matrix organization GO:0030198 9.61 VCAM1 SERPINE1 MMP9 MMP12 MMP1 ITGAM
25 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.6 TIMP2 TIMP1
26 membrane to membrane docking GO:0022614 9.59 VCAM1 ICAM1
27 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.58 ITGAL ICAM1
28 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.55 VCAM1 ITGA4
29 leukocyte cell-cell adhesion GO:0007159 9.55 VCAM1 SELP ITGAL ITGA4 ICAM1
30 leukocyte migration GO:0050900 9.28 SELP SELL MMP9 MMP1 ITGAM ITGAL

Molecular functions related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.11 TIMP2 TIMP1 SELP SELL MMP9 MMP12
2 peptidase activity GO:0008233 9.83 PLAT MMP9 MMP12 MMP1 F2
3 endopeptidase activity GO:0004175 9.65 MMP9 MMP12 MMP1
4 serine-type endopeptidase activity GO:0004252 9.62 PLAT MMP9 MMP1 F2
5 cell adhesion molecule binding GO:0050839 9.58 VCAM1 ITGAL ITGA4
6 oligosaccharide binding GO:0070492 9.46 SELP SELL
7 heparin binding GO:0008201 9.46 VEGFA SELP SELL F2
8 glycosphingolipid binding GO:0043208 9.26 SELP SELL
9 protease binding GO:0002020 9.26 TIMP2 TIMP1 SERPINE1 SELL
10 integrin binding GO:0005178 9.02 VCAM1 TIMP2 ITGAM ITGA4 ICAM1

Sources for Chronic Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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