MCID: CHR431
MIFTS: 50

Chronic Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Chronic Venous Insufficiency

MalaCards integrated aliases for Chronic Venous Insufficiency:

Name: Chronic Venous Insufficiency 12 56 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0050853
UMLS 74 C1306557

Summaries for Chronic Venous Insufficiency

Disease Ontology : 12 A venous insufficiency that is characterized by lower extremity swelling, hyperpigmentation, pruritus and venous ulceration caused by blood pooling in the veins.

MalaCards based summary : Chronic Venous Insufficiency is related to varicose veins and thrombophlebitis. An important gene associated with Chronic Venous Insufficiency is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Troxerutin have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 77 Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining... more...

Related Diseases for Chronic Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Chronic Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 varicose veins 30.4 MMP1 MMP9 TIMP1
2 thrombophlebitis 30.2 PLAT SERPINE1
3 thrombosis 30.1 PLAT SELP SERPINE1
4 lipodermatosclerosis 29.9 MMP1 PLAT
5 vasculitis 29.7 ICAM1 SELL VCAM1
6 peripheral vascular disease 29.6 PLAT SELP SERPINE1 VCAM1
7 localized scleroderma 29.6 MMP1 VCAM1
8 arteriosclerosis obliterans 29.4 ICAM1 SELP VCAM1
9 heart disease 29.1 ICAM1 PLAT SELP SERPINE1
10 venous insufficiency 28.9 ICAM1 ITGA4 MMP1 MMP9 PLAT SELL
11 arteriosclerosis 28.5 ICAM1 MMP9 SELP SERPINE1 VCAM1
12 vascular disease 28.4 ITGAM MMP9 PLAT SELP SERPINE1 VCAM1
13 fibrinolytic defect 10.3 PLAT SERPINE1
14 plasminogen activator inhibitor-1 deficiency 10.3 PLAT SERPINE1
15 cohen syndrome 10.3 ITGAM SELL
16 argentine hemorrhagic fever 10.3 PLAT SERPINE1
17 central serous chorioretinopathy 10.3 PLAT SERPINE1
18 peliosis hepatis 10.2 ITGA4 SELL
19 granulocytopenia 10.2 ITGAM SELL
20 toxicodendron dermatitis 10.2 ICAM1 SELL
21 acute cor pulmonale 10.2 PLAT SERPINE1
22 acute pulmonary heart disease 10.2 PLAT SERPINE1
23 plummer's disease 10.2 ICAM1 SELL
24 hydrocele 10.2 ICAM1 ITGA4
25 arthus reaction 10.2 ICAM1 SELL
26 conjunctivochalasis 10.2 MMP1 TIMP1
27 cortical thymoma 10.2 ICAM1 VCAM1
28 post-thrombotic syndrome 10.2 ICAM1 SERPINE1
29 brachydactyly, type e2 10.1 ICAM1 VCAM1
30 coronary thrombosis 10.1 PLAT SERPINE1
31 bronchopulmonary dysplasia 10.1 ITGAM SELL TIMP1
32 rheumatoid vasculitis 10.1 ICAM1 VCAM1
33 limbal stem cell deficiency 10.1 ICAM1 VCAM1
34 kaposi sarcoma 10.1
35 thrombophilia due to thrombin defect 10.1
36 sarcoma 10.1
37 platelet aggregation, spontaneous 10.1 PLAT SELP
38 legg-calve-perthes disease 10.1 SELP SERPINE1
39 amaurosis fugax 10.1 MMP9 SERPINE1
40 chronic eosinophilic pneumonia 10.1 ICAM1 ITGA4 ITGAM
41 gingival disease 10.1 MMP1 TIMP1
42 portal vein thrombosis 10.1 SELP SERPINE1
43 autoimmune inner ear disease 10.1 MMP9 TIMP1
44 ischemic colitis 10.1 MMP9 SERPINE1
45 pediatric multiple sclerosis 10.1 ITGA4 MMP9
46 mooren's ulcer 10.1 ICAM1 ITGA4 VCAM1
47 actinic prurigo 10.0 ICAM1 ITGA4 VCAM1
48 leukocyte adhesion deficiency, type i 10.0 ICAM1 ITGAM SELL
49 subendocardial myocardial infarction 10.0 ICAM1 SERPINE1 VCAM1
50 crescentic glomerulonephritis 10.0 ICAM1 SERPINE1 VCAM1

Graphical network of the top 20 diseases related to Chronic Venous Insufficiency:



Diseases related to Chronic Venous Insufficiency

Symptoms & Phenotypes for Chronic Venous Insufficiency

MGI Mouse Phenotypes related to Chronic Venous Insufficiency:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ICAM1 ITGA4 MMP9 PLAT SELL SELP
2 hematopoietic system MP:0005397 10.07 ICAM1 ITGA4 ITGAM MMP9 PLAT SELL
3 cellular MP:0005384 10.03 ICAM1 ITGA4 ITGAM MMP9 PLAT SELL
4 homeostasis/metabolism MP:0005376 10.02 ICAM1 ITGAM MMP1 MMP9 PLAT SELL
5 growth/size/body region MP:0005378 10.01 ICAM1 MMP9 PLAT SELL SELP SERPINE1
6 immune system MP:0005387 10 ICAM1 ITGA4 ITGAM MMP1 MMP9 PLAT
7 integument MP:0010771 9.63 ICAM1 MMP9 PLAT SELL SELP SERPINE1
8 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
9 respiratory system MP:0005388 9.1 MMP9 PLAT SELL SELP SERPINE1 TIMP1

Drugs & Therapeutics for Chronic Venous Insufficiency

Drugs for Chronic Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4,Phase 3 520-26-3 53477767
2
Troxerutin Investigational Phase 4,Not Applicable 7085-55-4 5486699
3
Coumarin Experimental Phase 4 91-64-5 323
4 Anesthetics Phase 4,Not Applicable
5 Anticoagulants Phase 4,Phase 3,Not Applicable
6 Heparinoids Phase 4
7 Salicylates Phase 4
8 Hemostatics Phase 4
9 Aminaftone Phase 4
10 Coagulants Phase 4
11 Anti-Inflammatory Agents Phase 4,Not Applicable
12 Sclerosing Solutions Phase 4
13
Sodium Citrate Approved, Investigational Phase 3,Phase 1,Phase 2 68-04-2
14
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
15
tannic acid Approved Phase 3 1401-55-4
16
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
17
Tinzaparin Approved Phase 3 9041-08-1, 9005-49-6 25244225
18
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 46507594 772
19
Dalteparin Approved Phase 3 9005-49-6
20
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 77-92-9 311
21
Calcium Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
22 Citrate Phase 3,Phase 1,Phase 2
23 Tin Fluorides Phase 3
24 Fibrinolytic Agents Phase 3,Not Applicable
25 Heparin, Low-Molecular-Weight Phase 3
26 Calcium, Dietary Phase 3,Phase 2,Phase 1,Not Applicable
27 calcium heparin Phase 3,Not Applicable
28 Grape Approved Phase 2
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
30
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
31
Horse chestnut Experimental Phase 2
32 Vitamins Phase 2
33 Vitamin B Complex Phase 2
34 Nutrients Phase 2,Not Applicable
35 Butcher's Broom Phase 2
36 Trace Elements Phase 2,Not Applicable
37 Folate Phase 2
38 Vitamin B9 Phase 2
39 Micronutrients Phase 2,Not Applicable
40 Vitamin B 6 Phase 2
41 Bone Density Conservation Agents Phase 2
42 Hormones Phase 2
43 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
44 Anti-Infective Agents Phase 1, Phase 2,Not Applicable
45
Pyridoxal Experimental, Nutraceutical Phase 2 66-72-8 1050
46
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 2713 9552079
47
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
48
Ticlopidine Approved Not Applicable 55142-85-3 5472
49
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
50
Pentoxifylline Approved, Investigational Not Applicable 6493-05-6 4740

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
2 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
3 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
4 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
5 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
6 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
7 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
9 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
10 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
11 Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy Recruiting NCT03416413 Phase 4 Foam sclerotherapy
12 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
13 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Terminated NCT02248740 Phase 4
14 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
15 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
16 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Unknown status NCT02927483 Phase 3
17 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
18 PRP ULCERAS: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
19 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
20 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
21 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
22 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
23 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
24 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
25 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
26 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
27 The MUFFIN-PTS Trial Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
28 Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Withdrawn NCT00273234 Phase 3
29 Great Saphenous Vein Electrocoagulation Unknown status NCT02139085 Phase 2
30 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
31 Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
32 The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
33 Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
34 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
35 Antistax® in Patients With Chronic Venous Insufficiency Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
36 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Completed NCT01817218 Phase 1, Phase 2 Platelet Rich Plasma
37 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
38 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers Recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
39 Efficacy Study of Kinesio Taping to Treat Muscular and Joint Problems in Chronic Venous Insufficiency Completed NCT01501188 Phase 1
40 Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
41 Safety and Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01346553 Not Applicable
42 The Clinical Trial for Primary Chronic Venous Insufficiency Unknown status NCT00931424 Not Applicable
43 Validation of a New Method of Limb Volumetry Unknown status NCT01574911
44 Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1) Unknown status NCT02662127 Not Applicable
45 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
46 Aqua Therapy in Deep Venous Thrombosis and Insufficiency Unknown status NCT02553720 Not Applicable
47 Prospective Multicentric Trial Between Radiofrequency Ablation With VNUS Closure Fast ® and Endovenous Ablation With 1470 nm Diode Laser and Tulip Fiber ® for Treatment of Primary Venous Insufficiency. Unknown status NCT01722019 Not Applicable
48 Vascular Ultrasound Versus Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction Unknown status NCT02240914
49 A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic Value Unknown status NCT00759434 Not Applicable
50 Pelvic Embolisation to Reduce Recurrent Varicose Veins - Recurrent Unknown status NCT01909024 Not Applicable

Search NIH Clinical Center for Chronic Venous Insufficiency

Genetic Tests for Chronic Venous Insufficiency

Anatomical Context for Chronic Venous Insufficiency

MalaCards organs/tissues related to Chronic Venous Insufficiency:

42
Skin, Heart, Endothelial, Neutrophil, Bone, Testes, Monocytes

Publications for Chronic Venous Insufficiency

Articles related to Chronic Venous Insufficiency:

(show top 50) (show all 641)
# Title Authors Year
1
Duplex ultrasound findings and clinical classification of lower extremity chronic venous insufficiency in a Thai population. ( 30477978 )
2019
2
Protocol for a longitudinal cohort study: determination of risk factors for the development of first venous leg ulcer in people with chronic venous insufficiency, the VEINS (venous insufficiency in South Florida) cohort. ( 30610020 )
2019
3
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. ( 30691376 )
2019
4
Prevalence, risk factors, and evaluation of iliocaval obstruction in advanced chronic venous insufficiency. ( 30765330 )
2019
5
Ultrasound-based topographic analysis of tributary vein connection with the saphenous vein during ambulatory conservative hemodynamic correction of chronic venous insufficiency. ( 30777672 )
2019
6
Effects of preventive use of compression stockings for elderly with chronic venous insufficiency and swollen legs: a systematic review and meta-analysis. ( 30845919 )
2019
7
Chronic Venous Insufficiency and Dystrophic Subcutaneous Calcification. ( 30896399 )
2019
8
Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). ( 30940301 )
2019
9
Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency. ( 30970086 )
2019
10
Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins. ( 30995000 )
2019
11
A Wearable Compression Device to Normalise Calf Muscle Pump Function in Chronic Venous Insufficiency for Each Postural Position. ( 31003934 )
2019
12
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. ( 31096120 )
2019
13
Chronic venous insufficiency: a new concept to understand pathophysiology at the microvascular level - a pilot study. ( 30067139 )
2019
14
Chronic venous insufficiency and varicose veins of the lower extremities. ( 30360023 )
2019
15
Commentary on "A Wearable Compression Device Normalises Calf Muscle Pump Function in Chronic Venous Insufficiency by Applying Appropriate Pressures for Each Postural Position". ( 30777601 )
2019
16
Implication of the PI3K/Akt/mTOR Pathway in the Process of Incompetent Valves in Patients with Chronic Venous Insufficiency and the Relationship with Aging. ( 30057669 )
2018
17
Dystrophic Calcifications in Chronic Venous Insufficiency. ( 30551796 )
2018
18
An Automatic Classification Method on Chronic Venous Insufficiency Images. ( 30560945 )
2018
19
LivRelief varicose veins cream in the treatment of chronic venous insufficiency of the lower limbs: A 6-week single arm pilot study. ( 30596677 )
2018
20
Evaluation of Arterial Stiffness Using Pulse Wave Velocity and Augmentation Index in Patients with Chronic Venous Insufficiency. ( 30631600 )
2018
21
Advantages and disadvantages of graduated and inverse graduated compression hosiery in patients with chronic venous insufficiency and healthy volunteers: A prospective, mono-centric, blinded, open randomised, controlled and cross-over trial. ( 27932625 )
2018
22
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations. ( 28403688 )
2018
23
Venous ultrasonography findings and clinical correlations in 104 Thai patients with chronic venous insufficiency of the legs. ( 28503700 )
2018
24
Effects of isokinetic calf muscle exercise program on muscle strength and venous function in patients with chronic venous insufficiency. ( 28954574 )
2018
25
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
26
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
27
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
28
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
29
Frequency and Significance of Perforating Venous Insufficiency in Patients with Chronic Venous Insufficiency of Lower Extremity. ( 30002576 )
2018
30
Correlation of obesity & comorbid conditions with chronic venous insufficiency: Results of a single-centre study. ( 30082571 )
2018
31
Validation of a Gravitational Model to Study Local Endogenous Biomarkers in Chronic Venous Insufficiency. ( 30181065 )
2018
32
Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency. ( 30228853 )
2018
33
Acroangiodermatitis of Mali (Pseudo-Kaposi Sarcoma) Associated with Chronic Venous Insufficiency and Obesity: A Case Report. ( 30457563 )
2018
34
An Osteopathic Approach to Stasis Dermatitis and Chronic Venous Insufficiency. ( 30476998 )
2018
35
Venous flow during manual lymphatic drainage applied to different regions of the lower extremity in people with and without chronic venous insufficiency: a cross-sectional study. ( 27083323 )
2017
36
Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency. ( 27329669 )
2017
37
Effect of socio-demographic characteristics and clinical findings on the quality of life of patients with chronic venous insufficiency. ( 28007012 )
2017
38
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
39
The relationship between chronic venous insufficiency and diabetes mellitus. ( 28124879 )
2017
40
Endovenous laser ablation in patients with severe primary chronic venous insufficiency. ( 28139903 )
2017
41
A failure of preoperative duplex imaging to diagnose a lower extremity venous aneurysm in a patient with severe chronic venous insufficiency. ( 28255445 )
2017
42
Evaluation of inflammatory cell biomarkers in chronic venous insufficiency. ( 28379059 )
2017
43
Changing Medicare Utilization of Minimally Invasive Procedures for the Treatment of Chronic Venous Insufficiency. ( 28396193 )
2017
44
Chronic Venous Insufficiency: Novel Management Strategies for an Under-diagnosed Disease Process. ( 28459920 )
2017
45
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment. ( 28485865 )
2017
46
Increased inflammatory status in chronic venous insufficiency patients. ( 28592220 )
2017
47
Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. ( 28662285 )
2017
48
Case of chronic venous insufficiency-associated Kaposi's sarcoma in a Japanese patient. ( 28771851 )
2017
49
Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings. ( 28804235 )
2017
50
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency. ( 28873064 )
2017

Variations for Chronic Venous Insufficiency

Expression for Chronic Venous Insufficiency

Search GEO for disease gene expression data for Chronic Venous Insufficiency.

Pathways for Chronic Venous Insufficiency

Pathways related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 ICAM1 ITGA4 ITGAM MMP1 MMP9 SELL
2
Show member pathways
13.25 ICAM1 ITGA4 ITGAM MMP1 MMP9 SERPINE1
3
Show member pathways
13.19 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
4
Show member pathways
13.11 ITGA4 ITGAM MMP1 PLAT SELL SELP
5
Show member pathways
12.53 ICAM1 ITGA4 ITGAM MMP9 VCAM1
6
Show member pathways
12.18 ICAM1 PLAT SERPINE1
7 12.11 ITGAM MMP9 PLAT
8
Show member pathways
12.11 ITGA4 ITGAM MMP1 SELL SELP
9
Show member pathways
12.1 MMP1 SERPINE1 TIMP1
10
Show member pathways
12.08 ICAM1 ITGA4 ITGAM MMP1 MMP9 VCAM1
11
Show member pathways
12.05 ICAM1 ITGA4 ITGAM VCAM1
12 11.98 ICAM1 MMP9 PLAT VCAM1
13 11.97 ITGAM PLAT SERPINE1
14 11.96 ICAM1 ITGA4 SELL VCAM1
15
Show member pathways
11.91 ITGAM MMP9 PLAT
16 11.9 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
17 11.88 ICAM1 MMP9 SELP
18
Show member pathways
11.88 ICAM1 ITGA4 ITGAM MMP1 MMP9 SERPINE1
19 11.86 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1
20 11.83 ICAM1 MMP9 VCAM1
21 11.79 ICAM1 SERPINE1 VCAM1
22
Show member pathways
11.78 MMP1 MMP9 TIMP1
23 11.6 ICAM1 ITGAM SELP
24
Show member pathways
11.58 ICAM1 MMP1 MMP9 VCAM1
25 11.5 MMP1 MMP9 PLAT SERPINE1 TIMP1
26 11.49 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
27 11.45 ICAM1 SELP VCAM1
28 11.35 ICAM1 ITGA4 ITGAM VCAM1
29 11.34 MMP1 MMP9 SELL
30 11.24 ICAM1 VCAM1
31 11.23 ICAM1 ITGAM MMP9 PLAT SELP
32 11.2 MMP1 MMP9
33 11.08 ICAM1 MMP9 TIMP1
34 11.02 MMP9 PLAT
35 10.93 MMP1 TIMP1
36 10.87 MMP1 MMP9
37 10.84 ICAM1 VCAM1
38 10.74 PLAT SERPINE1

GO Terms for Chronic Venous Insufficiency

Cellular components related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 ICAM1 ITGA4 ITGAM MMP9 PLAT SERPINE1
2 collagen-containing extracellular matrix GO:0062023 9.62 ICAM1 MMP9 PLAT SERPINE1
3 extracellular space GO:0005615 9.56 ICAM1 ITGAM MMP9 PLAT SELP SERPINE1
4 external side of plasma membrane GO:0009897 9.55 ICAM1 ITGAM SELL SELP VCAM1
5 integrin complex GO:0008305 9.37 ITGA4 ITGAM
6 cell surface GO:0009986 9.1 ICAM1 ITGA4 ITGAM PLAT SELL VCAM1

Biological processes related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.85 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.8 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
3 response to hypoxia GO:0001666 9.73 ICAM1 PLAT VCAM1
4 regulation of immune response GO:0050776 9.73 ICAM1 ITGA4 SELL VCAM1
5 response to lipopolysaccharide GO:0032496 9.72 ICAM1 SELP VCAM1
6 platelet degranulation GO:0002576 9.69 SELP SERPINE1 TIMP1
7 extracellular matrix disassembly GO:0022617 9.65 MMP1 MMP9 TIMP1
8 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 ITGAM MMP9 SERPINE1 VCAM1
9 collagen catabolic process GO:0030574 9.59 MMP1 MMP9
10 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ICAM1 SERPINE1
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 ICAM1 SERPINE1
12 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELP VCAM1
13 endodermal cell differentiation GO:0035987 9.57 ITGA4 MMP9
14 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
15 calcium-mediated signaling using intracellular calcium source GO:0035584 9.54 SELP VCAM1
16 fibrinolysis GO:0042730 9.52 PLAT SERPINE1
17 positive regulation of leukocyte migration GO:0002687 9.49 ITGA4 SELP
18 membrane to membrane docking GO:0022614 9.46 ICAM1 VCAM1
19 leukocyte tethering or rolling GO:0050901 9.26 ITGA4 SELL SELP VCAM1
20 leukocyte migration GO:0050900 9.17 ICAM1 ITGA4 ITGAM MMP1 MMP9 SELL

Molecular functions related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 SELL SERPINE1 TIMP1
2 oligosaccharide binding GO:0070492 9.26 SELL SELP
3 cell adhesion molecule binding GO:0050839 9.13 ITGA4 SELL VCAM1
4 glycosphingolipid binding GO:0043208 8.62 SELL SELP

Sources for Chronic Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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