MCID: CHR431
MIFTS: 47

Chronic Venous Insufficiency

Categories: Cardiovascular diseases

Aliases & Classifications for Chronic Venous Insufficiency

MalaCards integrated aliases for Chronic Venous Insufficiency:

Name: Chronic Venous Insufficiency 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050853
UMLS 73 C1306557

Summaries for Chronic Venous Insufficiency

MalaCards based summary : Chronic Venous Insufficiency is related to thrombophlebitis and lipodermatosclerosis. An important gene associated with Chronic Venous Insufficiency is ITGA4 (Integrin Subunit Alpha 4), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Troxerutin and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and bone, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 76 Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining... more...

Related Diseases for Chronic Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Chronic Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 thrombophlebitis 30.2 PLAT SERPINE1
2 lipodermatosclerosis 29.9 MMP1 PLAT
3 thrombosis 29.7 PLAT SELP SERPINE1
4 varicose veins 29.7 MMP1 MMP9 TIMP1
5 chronic venous leg ulcers 29.5 ITGA4 MMP9 TIMP1
6 arteriosclerosis obliterans 29.0 ICAM1 SELP VCAM1
7 peripheral vascular disease 28.6 PLAT SELP SERPINE1 VCAM1
8 arteriosclerosis 27.1 ICAM1 MMP9 SELP SERPINE1 VCAM1
9 arteries, anomalies of 26.3 ICAM1 MMP9 PLAT SELP SERPINE1 VCAM1
10 vascular disease 25.6 ICAM1 ITGAM MMP9 PLAT SELP SERPINE1
11 venous insufficiency 25.5 ICAM1 ITGA4 MMP1 MMP9 PLAT SELL
12 granulocytopenia 10.6 ITGAM SELL
13 fibrinolytic defect 10.6 PLAT SERPINE1
14 plasminogen activator inhibitor-1 deficiency 10.6 PLAT SERPINE1
15 coronary restenosis 10.6 ITGA4 PLAT
16 argentine hemorrhagic fever 10.6 PLAT SERPINE1
17 central serous chorioretinopathy 10.6 PLAT SERPINE1
18 cohen syndrome 10.6 ITGAM SELL
19 acute cor pulmonale 10.5 PLAT SERPINE1
20 peliosis hepatis 10.5 ITGA4 SELL
21 toxicodendron dermatitis 10.5 ICAM1 SELL
22 acute pulmonary heart disease 10.5 PLAT SERPINE1
23 leukocyte adhesion deficiency, type i 10.5 ITGAM SELL
24 conjunctivochalasis 10.4 MMP1 TIMP1
25 plummer's disease 10.4 ICAM1 SELL
26 coronary thrombosis 10.4 PLAT SERPINE1
27 arthus reaction 10.4 ICAM1 SELL
28 post-thrombotic syndrome 10.4 ICAM1 SERPINE1
29 cortical thymoma 10.4 ICAM1 VCAM1
30 rheumatoid vasculitis 10.3 ICAM1 VCAM1
31 bronchopulmonary dysplasia 10.3 ITGAM SELL TIMP1
32 limbal stem cell deficiency 10.3 ICAM1 VCAM1
33 henoch-schoenlein purpura 10.2 ICAM1 VCAM1
34 quebec platelet disorder 10.2 SELP SERPINE1
35 platelet aggregation, spontaneous 10.2 PLAT SELP
36 legg-calve-perthes disease 10.2 SELP SERPINE1
37 gingival disease 10.2 MMP1 TIMP1
38 amaurosis fugax 10.2 MMP9 SERPINE1
39 autoimmune inner ear disease 10.2 MMP9 TIMP1
40 tendinosis 10.1 MMP1 TIMP1
41 diabetic foot ulcers 10.1 MMP9 TIMP1
42 pediatric multiple sclerosis 10.1 ITGA4 MMP9
43 portal vein thrombosis 10.1 SELP SERPINE1
44 mooren's ulcer 10.1 ICAM1 ITGA4 VCAM1
45 bone deterioration disease 10.1 MMP1 TIMP1
46 actinic prurigo 10.1 ICAM1 ITGA4 VCAM1
47 cryptogenic organizing pneumonia 10.1 MMP9 TIMP1
48 cytomegalovirus infection 10.1 ICAM1 VCAM1
49 conjunctival nevus 10.1 MMP9 TIMP1
50 subendocardial myocardial infarction 10.1 ICAM1 SERPINE1 VCAM1

Graphical network of the top 20 diseases related to Chronic Venous Insufficiency:



Diseases related to Chronic Venous Insufficiency

Symptoms & Phenotypes for Chronic Venous Insufficiency

MGI Mouse Phenotypes related to Chronic Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 VCAM1 TIMP1 SELL ITGA4 SELP MMP9
2 hematopoietic system MP:0005397 10.07 VCAM1 TIMP1 SELL ITGA4 ITGAM SELP
3 cellular MP:0005384 10.03 VCAM1 ITGA4 SELL ITGAM SELP MMP9
4 homeostasis/metabolism MP:0005376 10.02 VCAM1 SERPINE1 TIMP1 SELL ITGAM MMP1
5 growth/size/body region MP:0005378 10.01 TIMP1 VCAM1 SERPINE1 PLAT ICAM1 SELL
6 immune system MP:0005387 10 VCAM1 TIMP1 SELL ITGA4 ITGAM MMP1
7 integument MP:0010771 9.63 SERPINE1 SELL SELP MMP9 PLAT ICAM1
8 neoplasm MP:0002006 9.43 SERPINE1 TIMP1 SELL MMP1 MMP9 ICAM1
9 respiratory system MP:0005388 9.1 TIMP1 SERPINE1 SELL SELP MMP9 PLAT

Drugs & Therapeutics for Chronic Venous Insufficiency

Drugs for Chronic Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Troxerutin Investigational Phase 4,Not Applicable 7085-55-4 5486699
2 Anesthetics Phase 4,Not Applicable
3 Anticoagulants Phase 4,Phase 3,Not Applicable
4 Heparinoids Phase 4
5 Salicylates Phase 4
6 Aminaftone Phase 4
7 Coagulants Phase 4
8 Hemostatics Phase 4
9 Anti-Inflammatory Agents Phase 4,Not Applicable
10
Coumarin Experimental, Nutraceutical Phase 4 91-64-5 323
11
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
12
Dalteparin Approved Phase 3 9005-49-6
13
Heparin Approved, Investigational Phase 3,Not Applicable 9005-49-6 772 46507594
14
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
15 tannic acid Approved, Nutraceutical Phase 3
16
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 1,Phase 2 77-92-9 311
17 Tin Fluorides Phase 3
18 calcium heparin Phase 3,Not Applicable
19 Calcium, Dietary Phase 3,Phase 2,Phase 1,Not Applicable
20 Fibrinolytic Agents Phase 3,Not Applicable
21 Heparin, Low-Molecular-Weight Phase 3
22
Hesperidin Experimental, Investigational, Nutraceutical Phase 3 520-26-3 53477767
23 Citrate Nutraceutical Phase 3,Phase 1,Phase 2
24
Alginic acid Approved, Investigational Phase 1, Phase 2 9005-32-7
25
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
26
Pyridoxal Approved, Nutraceutical Phase 2 66-72-8 1050
27
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
28 Grape Approved, Nutraceutical Phase 2
29 Micronutrients Phase 2,Not Applicable
30 Trace Elements Phase 2,Not Applicable
31 Vitamin B 6 Phase 2
32 Vitamin B Complex Phase 2
33 Vitamins Phase 2
34 Bone Density Conservation Agents Phase 2
35 Anti-Bacterial Agents Phase 1, Phase 2,Not Applicable
36 Anti-Infective Agents Phase 1, Phase 2,Not Applicable
37 Butcher's Broom Nutraceutical Phase 2
38 Folate Nutraceutical Phase 2
39
Horse chestnut Experimental, Nutraceutical Phase 2
40 Vitamin B9 Nutraceutical Phase 2
41
Menthol Approved Not Applicable 2216-51-5 16666
42
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
43
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
44
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
45
Pentoxifylline Approved, Investigational Not Applicable 6493-05-6 4740
46
Ticlopidine Approved Not Applicable 55142-85-3 5472
47
Copper Approved, Investigational Not Applicable 7440-50-8 27099
48
Polidocanol Approved 9002-92-0
49
Amikacin Approved, Investigational, Vet_approved Not Applicable 37517-28-5 37768
50
Teicoplanin Approved, Investigational Not Applicable 61036-62-2

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
2 Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins Completed NCT02346058 Phase 4 Esarin Gel
3 Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
4 Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
5 Iliac Vein Stenting in Advanced Chronic Venous Insufficiency Completed NCT02149212 Phase 4 Phlebotonic
6 Practicability of Gliding Aids for Medical Compression Stockings Completed NCT01432795 Phase 4
7 Tolerability of Antistax® in Patients Suffering From Chronic Venous Insufficiency (CVI) Completed NCT02184234 Phase 4 Antistax film coated tablets
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein Completed NCT02236338 Phase 4
9 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein Completed NCT02248740 Phase 4
10 Neuromuscular Electrical Therapy in Venous Ulcers Completed NCT01372020 Phase 4
11 ClosureFAST vs. Laser Ablation for the Treatment of GSV Disease: A Multicenter, Single-Blinded, Randomized Study. Completed NCT00509392 Phase 4
12 Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy Recruiting NCT03416413 Phase 4 Foam sclerotherapy
13 Study of Antiinflammatory Effects of Detralex (Daflon) Enrolling by invitation NCT01654016 Phase 4 Detralex
14 Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
15 Efficacy and Tolerability of the Use of Varicell Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
16 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
17 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency Completed NCT01956318 Phase 3
18 Efficacy and Tolerability of Antistax® in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
19 Assess the Efficacy and Tolerability of Antistax Film-coated Tablets in Patients With Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
20 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema Completed NCT01402921 Phase 3
21 THERMES ET VEINES: Spa for Prevention of Leg Ulcers Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
22 Efficacy and Tolerability CVI (A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial (CVI) Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
23 The Influence of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Disease Completed NCT00196443 Phase 2, Phase 3
24 Evaluation of Long-Term Sequelae After Thrombophlebitis, i.e. Deep Venous Thrombosis of the Lower Extremities Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
25 PRP ULCERAS: Clinical Trial Phase III Active, not recruiting NCT02213952 Phase 3 Platelet-Rich Plasma
26 Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insufficiency Not yet recruiting NCT02927483 Phase 3
27 Clinical Effectiveness of Topical Autologous Platelet Gel for the Treatment of Venous Ulcers Withdrawn NCT00273234 Phase 3
28 Great Saphenous Vein Electrocoagulation Unknown status NCT02139085 Phase 2
29 Non-Healing Ulcers Without Critical Limb Ischemia Unknown status NCT01666093 Phase 2
30 Venavine Intensive® in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
31 The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
32 Efficacy of Antistax® in Improving Microcirculation of the Skin in the Leg in Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
33 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
34 Antistax® in Patients With Chronic Venous Insufficiency Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
35 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Completed NCT01817218 Phase 1, Phase 2 Platelet Rich Plasma
36 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
37 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers Recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
38 Efficacy Study of Kinesio Taping to Treat Muscular and Joint Problems in Chronic Venous Insufficiency Completed NCT01501188 Phase 1
39 Safety and Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01346553 Not Applicable
40 The Clinical Trial for Primary Chronic Venous Insufficiency Unknown status NCT00931424 Not Applicable
41 Validation of a New Method of Limb Volumetry Unknown status NCT01574911
42 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
43 Aqua Therapy in Deep Venous Thrombosis and Insufficiency Unknown status NCT02553720 Not Applicable
44 Prospective Multicentric Trial Between Radiofrequency Ablation With VNUS Closure Fast ® and Endovenous Ablation With 1470 nm Diode Laser and Tulip Fiber ® for Treatment of Primary Venous Insufficiency. Unknown status NCT01722019 Not Applicable
45 Vascular Ultrasound Versus Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction Unknown status NCT02240914
46 A New Method of Surgically Treating Varicose Veins and Venous Ulcers - a Study to Assess Clinical and Economic Value Unknown status NCT00759434 Not Applicable
47 Chronic Venous Insufficiency; Impact of Compression Stockings on Quality of Life Completed NCT02050061 Not Applicable
48 Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial Completed NCT01899482 Not Applicable
49 LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency Completed NCT03104985 Not Applicable
50 Non-Invasive Management of Chronic Venous Insufficiency Completed NCT00950378

Search NIH Clinical Center for Chronic Venous Insufficiency

Genetic Tests for Chronic Venous Insufficiency

Anatomical Context for Chronic Venous Insufficiency

MalaCards organs/tissues related to Chronic Venous Insufficiency:

41
Skin, Endothelial, Bone, Heart, Neutrophil, Monocytes, Breast

Publications for Chronic Venous Insufficiency

Articles related to Chronic Venous Insufficiency:

(show top 50) (show all 317)
# Title Authors Year
1
The influence of exercise on ulcer healing in patients with chronic venous insufficiency. ( 29368880 )
2018
2
US budget impact of increased payer adoption of the Flexitouch advanced pneumatic compression device in lymphedema patients with advanced chronic venous insufficiency and multiple infections. ( 29975564 )
2018
3
Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)-A pilot study. ( 29377939 )
2018
4
Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. ( 29439934 )
2018
5
Ultrasound-guided foam sclerotherapy for severe chronic venous insufficiency. ( 29019582 )
2017
6
Case of chronic venous insufficiency-associated Kaposi's sarcoma in a Japanese patient. ( 28771851 )
2017
7
Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. ( 28662285 )
2017
8
Increased inflammatory status in chronic venous insufficiency patients. ( 28592220 )
2017
9
Advanced Chronic Venous Insufficiency. ( 28024458 )
2017
10
Quantification of early cutaneous manifestations of chronic venous insufficiency by automated analysis of photographic images: Feasibility and technical considerations. ( 28403688 )
2017
11
Changing Medicare Utilization of Minimally Invasive Procedures for the Treatment of Chronic Venous Insufficiency. ( 28396193 )
2017
12
Chronic Venous Insufficiency: a Frequently Underdiagnosed and Undertreated Pathology. ( 28878840 )
2017
13
A failure of preoperative duplex imaging to diagnose a lower extremity venous aneurysm in a patient with severe chronic venous insufficiency. ( 28255445 )
2017
14
TGF-I^1 in Vascular Wall Pathology: Unraveling Chronic Venous Insufficiency Pathophysiology. ( 29186866 )
2017
15
A Systematic Review and Meta-analysis of Exercise Intervention for the Treatment of Calf Muscle Pump Impairment in Individuals with Chronic Venous Insufficiency. ( 28873064 )
2017
16
Venous ultrasonography findings and clinical correlations in 104 Thai patients with chronic venous insufficiency of the legs. ( 28503700 )
2017
17
Chronic venous insufficiency - a review of pathophysiology, diagnosis, and treatment. ( 28485865 )
2017
18
Efficiency of a New Combined Laser Therapy in Patients With Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency. ( 29123633 )
2017
19
Contact Sensitization in Patients With Lower Leg Dermatitis, Chronic Venous Insufficiency, and/or Chronic Leg Ulcer: Assessment of the Clinical Relevance of Contact Allergens. ( 29199962 )
2017
20
The relationship between chronic venous insufficiency and diabetes mellitus. ( 28124879 )
2017
21
Chronic Venous Insufficiency: Transforming Growth Factor-I^ Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing. ( 29065449 )
2017
22
Evaluation of inflammatory cell biomarkers in chronic venous insufficiency. ( 28379059 )
2017
23
Chronic Venous Insufficiency: Novel Management Strategies for an Under-diagnosed Disease Process. ( 28459920 )
2017
24
The calendar of cytokines: Seasonal variation of circulating cytokines in chronic venous insufficiency. ( 28959442 )
2017
25
Management of Varicose Veins and Chronic Venous Insufficiency in a Comparative Registry with Nine Venoactive Products in Comparison with Stockings. ( 28804235 )
2017
26
Effects of isokinetic calf muscle exercise program on muscle strength and venous function in patients with chronic venous insufficiency. ( 28954574 )
2017
27
Endovenous laser ablation in patients with severe primary chronic venous insufficiency. ( 28139903 )
2017
28
Venous flow during manual lymphatic drainage applied to different regions of the lower extremity in people with and without chronic venous insufficiency: a cross-sectional study. ( 27083323 )
2016
29
Physical exercise for the treatment of non-ulcerated chronic venous insufficiency. ( 27914110 )
2016
30
Effect of socio-demographic characteristics and clinical findings on the quality of life of patients with chronic venous insufficiency. ( 28007012 )
2016
31
The Impact of Race on Advanced Chronic Venous Insufficiency. ( 27179983 )
2016
32
Compression in the treatment of chronic venous insufficiency: Efficacy depending on the length of the stocking. ( 27886005 )
2016
33
Frequency of Peripheral Arterial Disease in Patients With Chronic Venous Insufficiency. ( 26889387 )
2016
34
Advantages and disadvantages of graduated and inverse graduated compression hosiery in patients with chronic venous insufficiency and healthy volunteers: A prospective, mono-centric, blinded, open randomised, controlled and cross-over trial. ( 27932625 )
2016
35
The effects of short-term use of compression stockings on health related quality of life in patients with chronic venous insufficiency. ( 27512248 )
2016
36
Venoplasty and Venous Stenting in Patients with Chronic Venous Insufficiency in the Lower Extremities. ( 28496508 )
2016
37
Popliteal vein external banding at the valve-free segment to treat severe chronic venous insufficiency. ( 27131925 )
2016
38
Effect of TGF-beta1 on MMP/TIMP and TGF-beta1 receptors in great saphenous veins and its significance on chronic venous insufficiency. ( 27329669 )
2016
39
Doppler ultrasound study and venous mapping in chronic venous insufficiency. ( 26655801 )
2016
40
TCT-772 High prevalence of pelvic venous compression syndrome among patients with chronic venous insufficiency and effective treatment with venous stenting. ( 27970159 )
2016
41
Lymphatic transport in patients with chronic venous insufficiency and venous leg ulcers following sequential pneumatic compression. ( 26946890 )
2016
42
A randomized, double-blind, placebo-controlled, clinical study on the efficacy and safety of calcium dobesilate in the treatment of chronic venous insufficiency. ( 25991692 )
2015
43
Sulodexide suppresses inflammation in patients with chronic venous insufficiency. ( 26044841 )
2015
44
Donning devices (foot slips and frames) enable elderly people with severe chronic venous insufficiency to put on compression stockings. ( 25579875 )
2015
45
Symptoms in patients with skin changes due to chronic venous insufficiency often lead to emergency care service: an Italian observational study. ( 26345466 )
2015
46
A Clinical Comparison of Pycnogenol, Antistax, and Stocking in Chronic Venous Insufficiency. ( 26648668 )
2015
47
Aetiology and management of atrophie blanche in chronic venous insufficiency. ( 26639077 )
2015
48
Non-HIV-related Kaposi sarcoma in 2 Hispanic patients arising in the setting of chronic venous insufficiency. ( 26125221 )
2015
49
Adherence to and efficacy of different compression methods for treating chronic venous insufficiency in the elderly. ( 26518327 )
2015
50
A Prospective Randomized Study Comparing Polidocanol Foam Sclerotherapy with Surgical Treatment of Patients with Primary Chronic Venous Insufficiency and Ulcer. ( 26004968 )
2015

Variations for Chronic Venous Insufficiency

Expression for Chronic Venous Insufficiency

Search GEO for disease gene expression data for Chronic Venous Insufficiency.

Pathways for Chronic Venous Insufficiency

Pathways related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 ICAM1 ITGA4 ITGAM MMP1 MMP9 SELL
2
Show member pathways
13.24 ICAM1 ITGA4 ITGAM MMP1 MMP9 SERPINE1
3
Show member pathways
13.18 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
4
Show member pathways
13.11 ITGA4 ITGAM MMP1 PLAT SELL SELP
5
Show member pathways
12.52 ICAM1 ITGA4 ITGAM MMP9 VCAM1
6
Show member pathways
12.17 ICAM1 PLAT SERPINE1
7
Show member pathways
12.11 ITGA4 ITGAM MMP1 SELL SELP
8 12.1 ITGAM MMP9 PLAT
9
Show member pathways
12.08 MMP1 SERPINE1 TIMP1
10
Show member pathways
12.02 ICAM1 ITGA4 ITGAM VCAM1
11 11.97 ICAM1 MMP9 PLAT VCAM1
12 11.96 ITGAM PLAT SERPINE1
13 11.94 ICAM1 ITGA4 SELL VCAM1
14 11.89 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
15 11.88 ICAM1 MMP9 SELP
16
Show member pathways
11.88 ICAM1 ITGA4 ITGAM MMP1 MMP9 SERPINE1
17 11.86 ICAM1 ITGA4 MMP9 SERPINE1 VCAM1
18 11.82 ICAM1 MMP9 VCAM1
19 11.78 ICAM1 SERPINE1 VCAM1
20
Show member pathways
11.77 MMP1 MMP9 TIMP1
21
Show member pathways
11.58 ICAM1 MMP1 MMP9 VCAM1
22 11.51 ICAM1 ITGAM SELP
23 11.5 MMP1 MMP9 PLAT SERPINE1 TIMP1
24 11.49 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
25 11.44 ICAM1 SELP VCAM1
26 11.35 ICAM1 ITGA4 ITGAM VCAM1
27 11.33 MMP1 MMP9 SELL
28 11.23 ICAM1 ITGAM MMP9 PLAT SELP
29 11.21 ICAM1 VCAM1
30 11.2 MMP1 MMP9
31 11.07 ICAM1 MMP9 TIMP1
32 11.02 MMP9 PLAT
33 10.92 MMP1 TIMP1
34 10.86 MMP1 MMP9
35 10.83 ICAM1 VCAM1
36 10.73 PLAT SERPINE1

GO Terms for Chronic Venous Insufficiency

Cellular components related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 ICAM1 ITGA4 ITGAM MMP9 PLAT SERPINE1
2 extracellular space GO:0005615 9.86 ICAM1 ITGAM MMP9 PLAT SELP SERPINE1
3 cell surface GO:0009986 9.63 ICAM1 ITGA4 ITGAM PLAT SELL VCAM1
4 integrin complex GO:0008305 9.37 ITGA4 ITGAM
5 external side of plasma membrane GO:0009897 9.35 ICAM1 ITGAM SELL SELP VCAM1
6 extracellular matrix GO:0031012 9.1 ICAM1 MMP1 MMP9 PLAT SERPINE1 TIMP1

Biological processes related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.85 ICAM1 ITGA4 ITGAM SELL SELP VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.8 ICAM1 ITGAM MMP1 MMP9 TIMP1 VCAM1
3 response to lipopolysaccharide GO:0032496 9.74 ICAM1 SELP VCAM1
4 regulation of immune response GO:0050776 9.73 ICAM1 ITGA4 SELL VCAM1
5 response to hypoxia GO:0001666 9.72 ICAM1 PLAT VCAM1
6 platelet degranulation GO:0002576 9.69 SELP SERPINE1 TIMP1
7 extracellular matrix disassembly GO:0022617 9.65 MMP1 MMP9 TIMP1
8 extracellular matrix organization GO:0030198 9.63 ICAM1 ITGA4 ITGAM MMP9 SERPINE1 VCAM1
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 ICAM1 SERPINE1
10 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 ICAM1 SERPINE1
11 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.58 ICAM1 SELP VCAM1
12 endodermal cell differentiation GO:0035987 9.56 ITGA4 MMP9
13 leukocyte cell-cell adhesion GO:0007159 9.56 ICAM1 ITGA4 SELP VCAM1
14 fibrinolysis GO:0042730 9.54 PLAT SERPINE1
15 calcium-mediated signaling using intracellular calcium source GO:0035584 9.52 SELP VCAM1
16 positive regulation of leukocyte migration GO:0002687 9.49 ITGA4 SELP
17 membrane to membrane docking GO:0022614 9.46 ICAM1 VCAM1
18 leukocyte tethering or rolling GO:0050901 9.26 ITGA4 SELL SELP VCAM1
19 leukocyte migration GO:0050900 9.17 ICAM1 ITGA4 ITGAM MMP1 MMP9 SELL

Molecular functions related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 SELL SERPINE1 TIMP1
2 oligosaccharide binding GO:0070492 9.26 SELL SELP
3 cell adhesion molecule binding GO:0050839 9.13 ITGA4 SELL VCAM1
4 glycosphingolipid binding GO:0043208 8.62 SELL SELP

Sources for Chronic Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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