MCID: CHR431
MIFTS: 48

Chronic Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Chronic Venous Insufficiency

MalaCards integrated aliases for Chronic Venous Insufficiency:

Name: Chronic Venous Insufficiency 12 55 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050853
UMLS 72 C1306557

Summaries for Chronic Venous Insufficiency

Disease Ontology : 12 A venous insufficiency that is characterized by lower extremity swelling, hyperpigmentation, pruritus and venous ulceration caused by blood pooling in the veins.

MalaCards based summary : Chronic Venous Insufficiency is related to thrombophlebitis and post-thrombotic syndrome. An important gene associated with Chronic Venous Insufficiency is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and Integrin Pathway. The drugs Hesperidin and Rivaroxaban have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 75 Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining... more...

Related Diseases for Chronic Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Chronic Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 thrombophlebitis 31.1 SERPINE1 PLAT
2 post-thrombotic syndrome 31.1 SERPINE1 ICAM1
3 thrombosis 30.3 SERPINE1 SELP PLAT
4 lipodermatosclerosis 30.2 TIMP2 PLAT MMP1
5 amaurosis fugax 30.2 SERPINE1 MMP9
6 vasculitis 30.2 VCAM1 SELL ICAM1
7 varicose veins 29.9 TIMP2 TIMP1 MMP9 MMP1
8 peripheral vascular disease 29.7 VCAM1 SERPINE1 SELP PLAT
9 arteriosclerosis obliterans 29.6 VCAM1 SELP ICAM1
10 relapsing-remitting multiple sclerosis 29.5 TIMP1 MMP9 ICAM1
11 primary progressive multiple sclerosis 29.4 VCAM1 MMP9 ICAM1
12 localized scleroderma 29.0 VCAM1 MMP1
13 vascular disease 28.8 VCAM1 SERPINE1 SELP PLAT MMP9 ITGAM
14 proteasome-associated autoinflammatory syndrome 1 28.6 VCAM1 SELP SELL MMP9 ICAM1
15 arteriosclerosis 28.4 VCAM1 SERPINE1 SELP MMP9 ICAM1
16 cerebrovascular disease 27.8 VCAM1 SERPINE1 SELP PLAT MMP9 ICAM1
17 venous insufficiency 27.7 VCAM1 TIMP1 SERPINE1 SELP SELL PLAT
18 thrombophilia due to thrombin defect 10.6
19 fibrinolytic defect 10.5 SERPINE1 PLAT
20 plasminogen activator inhibitor-1 deficiency 10.5 SERPINE1 PLAT
21 central serous chorioretinopathy 10.5 SERPINE1 PLAT
22 argentine hemorrhagic fever 10.5 SERPINE1 PLAT
23 cohen syndrome 10.5 SELL ITGAM
24 toxicodendron dermatitis 10.5 SELL ICAM1
25 peliosis hepatis 10.4 SELL ITGA4
26 granulocytopenia 10.4 SELL ITGAM
27 acute cor pulmonale 10.4 SERPINE1 PLAT
28 hydrops, lactic acidosis, and sideroblastic anemia 10.4
29 hydrocele 10.4 ITGA4 ICAM1
30 dermatitis 10.4
31 plummer's disease 10.4 SELL ICAM1
32 acute pulmonary heart disease 10.4 SERPINE1 PLAT
33 dowling-degos disease 1 10.4
34 cortical thymoma 10.4 VCAM1 ICAM1
35 arthus reaction 10.4 SELL ICAM1
36 microcystic meningioma 10.3 TIMP2 TIMP1
37 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.3
38 brachydactyly, type e2 10.3 VCAM1 ICAM1
39 rheumatoid vasculitis 10.3 VCAM1 ICAM1
40 autoimmune inner ear disease 10.3 TIMP1 MMP9
41 bronchopulmonary dysplasia 10.3 TIMP1 SELL ITGAM
42 pediatric multiple sclerosis 10.3 MMP9 ITGA4
43 ischemic colitis 10.3 SERPINE1 MMP9
44 limbal stem cell deficiency 10.3 VCAM1 ICAM1
45 platelet aggregation, spontaneous 10.3 SELP PLAT
46 lymphedema 10.3
47 coronary thrombosis 10.2 SERPINE1 PLAT
48 conjunctival nevus 10.2 TIMP1 MMP9
49 cryptogenic organizing pneumonia 10.2 TIMP1 MMP9
50 kaposi sarcoma 10.2

Graphical network of the top 20 diseases related to Chronic Venous Insufficiency:



Diseases related to Chronic Venous Insufficiency

Symptoms & Phenotypes for Chronic Venous Insufficiency

MGI Mouse Phenotypes related to Chronic Venous Insufficiency:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 ICAM1 ITGA4 MMP9 PLAT SELL SELP
2 hematopoietic system MP:0005397 10.11 ICAM1 ITGA4 ITGAM MMP9 PLAT SELL
3 homeostasis/metabolism MP:0005376 10.06 ICAM1 ITGAM MMP1 MMP9 PLAT SELL
4 immune system MP:0005387 10.03 ICAM1 ITGA4 ITGAM MMP1 MMP9 PLAT
5 cellular MP:0005384 10.01 ICAM1 ITGA4 ITGAM MMP9 PLAT SELL
6 integument MP:0010771 9.63 ICAM1 MMP9 PLAT SELL SELP SERPINE1
7 neoplasm MP:0002006 9.43 ICAM1 MMP1 MMP9 SELL SERPINE1 TIMP1
8 respiratory system MP:0005388 9.1 MMP9 PLAT SELL SELP SERPINE1 TIMP1

Drugs & Therapeutics for Chronic Venous Insufficiency

Drugs for Chronic Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Rivaroxaban Approved Phase 4 366789-02-8
3
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
4
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
5
Coumarin Experimental Phase 4 91-64-5 323
6
Troxerutin Investigational Phase 4 7085-55-4 5486699
7 Salicylates Phase 4
8 Heparinoids Phase 4
9 Hemostatics Phase 4
10 Aminaftone Phase 4
11 Coagulants Phase 4
12 Antithrombin III Phase 4
13 HIV Protease Inhibitors Phase 4
14
protease inhibitors Phase 4
15 Serine Proteinase Inhibitors Phase 4
16 Antithrombins Phase 4
17 Factor Xa Inhibitors Phase 4
18 Anti-Inflammatory Agents Phase 4
19 Anticoagulants Phase 4
20 Anesthetics Phase 4
21 Fibrinolytic Agents Phase 4
22 Lipid Regulating Agents Phase 4
23 Glucuronyl glucosamine glycan sulfate Phase 4
24 Hypolipidemic Agents Phase 4
25 Hypoglycemic Agents Phase 4
26 Antimetabolites Phase 4
27
Polidocanol Approved Phase 3 9002-92-0
28
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
29
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
30
tannic acid Approved Phase 3 1401-55-4
31
Dalteparin Approved Phase 3 9005-49-6
32
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
33
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
34
Becaplermin Approved, Investigational Phase 3 165101-51-9
35
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
36 Pharmaceutical Solutions Phase 3
37 Sclerosing Solutions Phase 3
38 calcium heparin Phase 3
39 Tin Fluorides Phase 3
40 Calcium, Dietary Phase 3
41 Carboxymethylcellulose Sodium Phase 3
42 Heparin, Low-Molecular-Weight Phase 3
43 Mitogens Phase 3
44 Angiogenesis Modulating Agents Phase 3
45 Angiogenesis Inducing Agents Phase 3
46 Grape Approved Phase 2
47
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
48
Timolol Approved Phase 2 26839-75-8 33624 5478
49
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
50
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054

Interventional clinical trials:

(show top 50) (show all 102)
# Name Status NCT ID Phase Drugs
1 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
2 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
3 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
4 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
5 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
6 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
7 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
8 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
9 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
10 The Efficacy of Rivaroxaban With Diosmine in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
11 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Enrolling by invitation NCT01654016 Phase 4 Detralex
12 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
13 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide — SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
14 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
15 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
16 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
17 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
18 Efficacy of Autologous Platelet-Rich Plasma in the Treatment of Vascular Ulcers in Primary Care: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
19 Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy Unknown status NCT00529672 Phase 3
20 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
21 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
22 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
23 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
24 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
25 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
26 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
27 Deep Venous Thrombosis. Long-Term Results After Treatment With Either Low-Molecular -Weight Heparin or Unfractionated Heparin. Examinations of the Venous System. Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
28 Double Blind Randomized Controlled Trial of Recombinant Human Platelet Derived Growth Factor-BB Gel (Regranex Gel®) Versus Hydrogel (Duoderm Hydrogel®) for Healing of MARTORELL's Hypertensive Leg Ulcers. ERAN Trial. Completed NCT00970697 Phase 3 becaplermin gel;Duoderm Hydrogel™
29 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
30 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
31 A Prospective Double Blind Randomized Controlled Trial Of Electrocoagulation Versus Radiofrequency Treatment Of The Great Saphenous Vein In Patients With Varicose Veins. Unknown status NCT02139085 Phase 2
32 NON-HEALING ULCERS WITHOUT CRITICAL LIMB ISCHEMIA (NEWLI-Trial): A Single Center Pilot Trial on the Efficacy of an Endovascular Approach for Treatment of Non-healing Lower Limb Ulcers in Patients Presenting With a Mild to Moderate Peripheral Artery Disease Unknown status NCT01666093 Phase 2
33 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
34 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
35 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
36 A Randomized, Parallel Group, Controlled Study to Assess the Efficacy and Safety of NMBM in the Treatment of Subjects With a Post-cellulitis and Venous Leg Ulcer Completed NCT01770509 Phase 1, Phase 2
37 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
38 Topical Timolol Benefit in Venous Ulcers Completed NCT02422017 Phase 2 Timolol
39 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Compared to Moist Wound Care in a Primary Care Setting Completed NCT01817218 Phase 1, Phase 2 Platelet Rich Plasma
40 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
41 An Open Label Multicenter Safety Study of the Varisolve® Procedure for the Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
42 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
43 A Phase 1a, Open Label, Single Dose, Dose Response, Pilot Study to Evaluate the Safety and Tolerability of Human Fibroblast Growth Factor-1 (FGF-1) in Normal Volunteers Given Punch Skin Biopsies Unknown status NCT00916292 Phase 1 FGF-1 141;FGF-1 141
44 Study on the Effect of Kinesio Taping on Bioelectrical Activity of Gastrocnemius Muscles and Range of Ankle Motion in Post-menopausal Women With Chronic Venous Insufficiency Completed NCT01501188 Phase 1
45 Phase I Open-label, First-in-human Study to Evaluate Feasibility and Safety of Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
46 The Clinical Research of Surgery on Primary Chronic Venous Insufficiency Unknown status NCT00931424
47 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
48 Safety and Primary Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Sequel - A Pilot Study Unknown status NCT01346553
49 Prospective, Single-arm, Single Center, Pilot Study of Vascular Ultrasound Imaging Used as an Adjunct to Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction Unknown status NCT02240914
50 Aqua Therapy to Lower Adverse and Negative Effects of Deep Vein ThrombosIs and Post Thrombotic Syndrome Unknown status NCT02553720

Search NIH Clinical Center for Chronic Venous Insufficiency

Genetic Tests for Chronic Venous Insufficiency

Anatomical Context for Chronic Venous Insufficiency

MalaCards organs/tissues related to Chronic Venous Insufficiency:

41
Skin, Testes, Endothelial, Liver, Heart, Neutrophil, Monocytes

Publications for Chronic Venous Insufficiency

Articles related to Chronic Venous Insufficiency:

(show top 50) (show all 2564)
# Title Authors PMID Year
1
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. 9 38
15191401 2004
2
[Cytochromes P450, vascular tone varicosis]. 9 38
12843956 2003
3
[Changes in VCAM-1 cell adhesion molecule after phlebologic thermal care in chronic venous insufficiency of the lower limbs]. 9 38
11917667 2001
4
Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency. 9 38
10086854 1999
5
Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. 9 38
8609252 1996
6
Tissue-engineered transcatheter vein valve. 38
31195302 2019
7
Vascular training does matter in the outcomes of saphenous high ligation and stripping. 38
31068278 2019
8
Efficacy of balloon venoplasty alone in the correction of nonthrombotic iliac vein lesions. 38
31176659 2019
9
Overview of venous pathology related to repetitive vascular trauma in athletes. 38
31231058 2019
10
Mechanochemical ablation as an alternative to venous ulcer healing compared with thermal ablation. 38
31421838 2019
11
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. 38
30691376 2019
12
Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised study. 38
31014200 2019
13
Scientific Papers and Patents on Substances with Unproven Effects. Part 2. 38
31424374 2019
14
The influence of May-Thurner syndrome on post-thrombotic syndrome in young women. 38
30848698 2019
15
One-Year Results of Iliocaval Stenting. 38
30826434 2019
16
Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins. 38
31432124 2019
17
Therapeutic potential of natural compounds in inflammation and chronic venous insufficiency. 38
31096120 2019
18
High tolerance of progressive elastic compression in peripheral arterial disease. 38
31159678 2019
19
Chronic venous insufficiency and venous microangiopathy: management with compression and Pycnogenol®. 38
31347820 2019
20
Impact of Great Saphenous Vein Foam Sclerotherapy on Quality of Life and Photoplethysmography Findings in Chronic Venous Insufficiency: One-Year Follow-up. 38
31397782 2019
21
Histopathological changes to the vascular wall after treatment of great saphenous veins using n-butyl-2-cyanoacrylate. 38
31063085 2019
22
Defining the utility of anteroposterior venography in the diagnosis of venous iliofemoral obstruction. 38
30926244 2019
23
Is it necessary to dilate stents in management of nonthrombotic iliac vein lesions? 38
31203858 2019
24
Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review. 38
31339655 2019
25
A near-infrared spectroscopy-assisted test discriminates patients with peripheral arterial disease and venous insufficiency with changes of foot oxygenation following light elastic compression therapy. 38
30838936 2019
26
Medical compression stockings on the skin moisture in patients with chronic venous disease. 38
31364497 2019
27
[Chronic leg ulcers in older patients]. 38
31187184 2019
28
Saphenous vein histopathology 5.5 years after cyanoacrylate closure. 38
31281102 2019
29
A critical review on the three-dimensional finite element modelling of the compression therapy for chronic venous insufficiency. 38
31319767 2019
30
[Endovenous Treatment of Varicose Veins and Chronic Venous Insufficiency]. 38
31163465 2019
31
Evaluation of the Isokinetic Calf Muscle Strength and the Range of Motion of Joint in C3 Chronic Venous Insufficiency. 38
31297359 2019
32
Ankle joint mobility as a predictor of treatment prognosis in patients with chronic venous insufficiency with venous ulcers. 38
31360156 2019
33
Neoaorta Reconstruction Using Both Femoral Veins in a Patient with Secondary Aortoenteric Fistula. 38
31142428 2019
34
Protocol for a systematic review and meta-analysis of interventions for pathologic perforator veins in chronic venous disease. 38
31048426 2019
35
Preliminary report of a new type of braided vein stent in animals. 38
30227789 2019
36
Duplex ultrasound findings and clinical classification of lower extremity chronic venous insufficiency in a Thai population. 38
30477978 2019
37
Prevalence, risk factors, and evaluation of iliocaval obstruction in advanced chronic venous insufficiency. 38
30765330 2019
38
Ultrasound-based topographic analysis of tributary vein connection with the saphenous vein during ambulatory conservative hemodynamic correction of chronic venous insufficiency. 38
30777672 2019
39
Contact Dermatitis in the Elderly: Predisposing Factors, Diagnosis, and Management. 38
31037642 2019
40
Escin suppresses HMGB1-induced overexpression of aquaporin-1 and increased permeability in endothelial cells. 38
30972964 2019
41
A Wearable Compression Device to Normalise Calf Muscle Pump Function in Chronic Venous Insufficiency for Each Postural Position. 38
31003934 2019
42
Radiation exposure during non-thrombotic iliac vein stenting. 38
31067208 2019
43
Endovascular stenting for chronic femoro-iliac venous obstructive disease: Clinical efficacy and short-term outcomes. 38
31036535 2019
44
Paradigm shift in geriatric fracture treatment. 38
30725152 2019
45
Therapeutic approach to chronic venous insufficiency - clinical benefits of red-vine-leaf-extract AS 195 (Antistax®). 38
30940301 2019
46
Association Between Hemorrhoids and Lower Extremity Chronic Venous Insufficiency. 38
31249764 2019
47
Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency. 38
30970086 2019
48
[New methods of interventional treatment of varicose veins]. 38
31099760 2019
49
Cardiovascular Disease: Chronic Venous Insufficiency and Varicose Veins. 38
30995000 2019
50
Treatment of Leg Veins for Restless Leg Syndrome: A Retrospective Review. 38
31192073 2019

Variations for Chronic Venous Insufficiency

Expression for Chronic Venous Insufficiency

Search GEO for disease gene expression data for Chronic Venous Insufficiency.

Pathways for Chronic Venous Insufficiency

Pathways related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 VCAM1 TIMP2 TIMP1 SELL MMP9 MMP1
2
Show member pathways
13.27 VCAM1 SERPINE1 MMP9 MMP1 ITGAM ITGA4
3
Show member pathways
13.21 VCAM1 TIMP1 MMP9 MMP1 ITGAM ICAM1
4
Show member pathways
13.16 TIMP1 SERPINE1 SELP SELL PLAT MMP1
5
Show member pathways
12.55 VCAM1 MMP9 ITGAM ITGA4 ICAM1
6
Show member pathways
12.26 TIMP2 TIMP1 ITGAM ITGA4
7
Show member pathways
12.14 SELP SELL MMP1 ITGAM ITGA4
8 12.12 PLAT MMP9 ITGAM
9
Show member pathways
12.1 VCAM1 MMP9 MMP1 ITGAM ITGA4 ICAM1
10
Show member pathways
12.07 VCAM1 ITGAM ITGA4 ICAM1
11 12 VCAM1 PLAT MMP9 ICAM1
12 11.98 SERPINE1 PLAT ITGAM
13 11.98 VCAM1 SELL ITGA4 ICAM1
14 11.96 VCAM1 SELP SELL ITGAM ITGA4 ICAM1
15
Show member pathways
11.93 VCAM1 TIMP2 TIMP1 SERPINE1 MMP9 MMP1
16
Show member pathways
11.92 PLAT MMP9 ITGAM
17 11.9 SELP MMP9 ICAM1
18 11.89 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
19 11.86 VCAM1 MMP9 ICAM1
20
Show member pathways
11.83 TIMP2 TIMP1 MMP9 MMP1
21 11.8 VCAM1 SERPINE1 ICAM1
22 11.76 SELP ITGAM ICAM1
23 11.74 TIMP2 TIMP1 MMP9
24 11.69 VCAM1 TIMP1 MMP9 MMP1 ITGAM ICAM1
25 11.61 TIMP2 TIMP1 ITGAM ITGA4
26
Show member pathways
11.61 VCAM1 MMP9 MMP1 ICAM1
27 11.46 VCAM1 SELP ICAM1
28 11.4 VCAM1 ITGAM ITGA4 ICAM1
29 11.34 SELP PLAT MMP9 ITGAM ICAM1
30 11.32 TIMP2 SELL MMP9 MMP1
31 11.25 VCAM1 ICAM1
32 11.22 TIMP2 TIMP1 SERPINE1 PLAT MMP9 MMP1
33 11.21 MMP9 MMP1
34 11.07 TIMP2 TIMP1 MMP9 ICAM1
35 11.05 TIMP2 MMP9
36 11.03 PLAT MMP9
37 10.94 TIMP1 MMP1
38 10.89 MMP9 MMP1
39 10.88 TIMP2 TIMP1 ITGAM ITGA4
40 10.85 VCAM1 ICAM1
41 10.75 SERPINE1 PLAT

GO Terms for Chronic Venous Insufficiency

Cellular components related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.92 VCAM1 TIMP1 SERPINE1 PLAT MMP9 ITGAM
2 extracellular matrix GO:0031012 9.67 TIMP2 TIMP1 MMP9 MMP1
3 external side of plasma membrane GO:0009897 9.65 VCAM1 SELP SELL ITGAM ICAM1
4 extracellular space GO:0005615 9.61 VCAM1 TIMP2 TIMP1 SERPINE1 SELP PLAT
5 collagen-containing extracellular matrix GO:0062023 9.55 TIMP2 SERPINE1 PLAT MMP9 ICAM1
6 integrin complex GO:0008305 9.4 ITGAM ITGA4
7 cell surface GO:0009986 9.17 VCAM1 TIMP2 SELL PLAT ITGAM ITGA4

Biological processes related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.88 TIMP2 SELL MMP9 ITGAM
2 cell adhesion GO:0007155 9.88 VCAM1 SELP SELL ITGAM ITGA4 ICAM1
3 cytokine-mediated signaling pathway GO:0019221 9.8 VCAM1 TIMP1 MMP9 MMP1 ITGAM ICAM1
4 aging GO:0007568 9.79 VCAM1 TIMP2 TIMP1
5 response to hypoxia GO:0001666 9.78 VCAM1 PLAT ICAM1
6 regulation of immune response GO:0050776 9.78 VCAM1 SELL ITGA4 ICAM1
7 response to lipopolysaccharide GO:0032496 9.77 VCAM1 SELP ICAM1
8 negative regulation of endopeptidase activity GO:0010951 9.73 TIMP2 TIMP1 SERPINE1
9 platelet degranulation GO:0002576 9.72 TIMP1 SERPINE1 SELP
10 negative regulation of peptidase activity GO:0010466 9.71 TIMP2 TIMP1 SERPINE1
11 extracellular matrix disassembly GO:0022617 9.67 TIMP2 TIMP1 MMP9 MMP1
12 extracellular matrix organization GO:0030198 9.63 VCAM1 SERPINE1 MMP9 ITGAM ITGA4 ICAM1
13 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.62 SERPINE1 ICAM1
14 endodermal cell differentiation GO:0035987 9.62 MMP9 ITGA4
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.61 VCAM1 SELP ICAM1
16 negative regulation of proteolysis GO:0045861 9.6 TIMP2 PLAT
17 fibrinolysis GO:0042730 9.58 SERPINE1 PLAT
18 calcium-mediated signaling using intracellular calcium source GO:0035584 9.57 VCAM1 SELP
19 leukocyte cell-cell adhesion GO:0007159 9.56 VCAM1 SELP ITGA4 ICAM1
20 positive regulation of leukocyte migration GO:0002687 9.52 SELP ITGA4
21 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.51 TIMP2 TIMP1
22 membrane to membrane docking GO:0022614 9.49 VCAM1 ICAM1
23 negative regulation of metallopeptidase activity GO:1905049 9.46 TIMP2 TIMP1
24 leukocyte tethering or rolling GO:0050901 9.26 VCAM1 SELP SELL ITGA4
25 leukocyte migration GO:0050900 9.1 SELP SELL MMP1 ITGAM ITGA4 ICAM1

Molecular functions related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.58 VCAM1 TIMP2 ICAM1
2 peptidase inhibitor activity GO:0030414 9.5 TIMP2 TIMP1 SERPINE1
3 metalloendopeptidase inhibitor activity GO:0008191 9.37 TIMP2 TIMP1
4 cell adhesion molecule binding GO:0050839 9.33 VCAM1 SELL ITGA4
5 oligosaccharide binding GO:0070492 9.26 SELP SELL
6 glycosphingolipid binding GO:0043208 8.96 SELP SELL
7 protease binding GO:0002020 8.92 TIMP2 TIMP1 SERPINE1 SELL
8 metal ion binding GO:0046872 10.03 TIMP2 TIMP1 SELP SELL MMP9 MMP1

Sources for Chronic Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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