MCID: CHR431
MIFTS: 49

Chronic Venous Insufficiency

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Chronic Venous Insufficiency

MalaCards integrated aliases for Chronic Venous Insufficiency:

Name: Chronic Venous Insufficiency 12 54 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050853
UMLS 71 C1306557

Summaries for Chronic Venous Insufficiency

Disease Ontology : 12 A venous insufficiency that is characterized by lower extremity swelling, hyperpigmentation, pruritus and venous ulceration caused by blood pooling in the veins.

MalaCards based summary : Chronic Venous Insufficiency is related to thrombophilia due to thrombin defect and lipodermatosclerosis. An important gene associated with Chronic Venous Insufficiency is VCAM1 (Vascular Cell Adhesion Molecule 1), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. The drugs Hesperidin and Rivaroxaban have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 74 Chronic venous insufficiency (CVI) is a medical condition in which blood pools in the veins, straining... more...

Related Diseases for Chronic Venous Insufficiency

Diseases in the Venous Insufficiency family:

Chronic Venous Insufficiency

Diseases related to Chronic Venous Insufficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 389)
# Related Disease Score Top Affiliating Genes
1 thrombophilia due to thrombin defect 30.7 SERPINE1 PLAT MTHFR F2
2 lipodermatosclerosis 30.4 VEGFA TIMP2 PLAT MMP1
3 post-thrombotic syndrome 30.4 VCAM1 SERPINE1 PLAT ICAM1 F2
4 hemorrhoid 30.2 MMP9 F2 CRP
5 relapsing-remitting multiple sclerosis 29.9 TIMP1 MMP9 ITGA4 ICAM1
6 amaurosis fugax 29.9 SERPINE1 MTHFR MMP9
7 arteriosclerosis obliterans 29.8 VCAM1 SELP MMP9 ICAM1
8 buerger disease 29.8 SERPINE1 MTHFR F2
9 purpura 29.8 SELP F2 CRP
10 intracranial hypertension 29.8 SERPINE1 MTHFR F2
11 pyoderma 29.7 MMP9 MMP1 CRP
12 chronic ulcer of skin 29.7 VEGFA TIMP2 MMP1 CRP
13 thrombophilia 29.6 SERPINE1 SELP PLAT MTHFR F2
14 skin disease 29.6 SELL MMP1 ITGAL ICAM1 CRP
15 localized scleroderma 29.5 VCAM1 TGFB1 MMP1
16 pulmonary embolism 29.4 SERPINE1 PLAT MTHFR F2 CRP
17 homocysteinemia 29.4 VCAM1 SERPINE1 MTHFR F2 CRP
18 dermatitis, atopic 29.4 VCAM1 TIMP1 SELP SELL ITGAM ICAM1
19 proteasome-associated autoinflammatory syndrome 1 29.3 VCAM1 SELP SELL MMP9 ICAM1 CRP
20 primary progressive multiple sclerosis 29.2 VCAM1 TIMP1 SELL MMP9 ITGAL ITGA4
21 vasculitis 29.2 VCAM1 SELP SELL ITGAM ITGA4 ICAM1
22 thrombosis 29.1 VCAM1 SERPINE1 SELP PLAT MTHFR F2
23 varicose veins 29.0 VEGFA TIMP2 TIMP1 PLAT MTHFR MMP9
24 thrombophlebitis 28.8 TGFB1 SERPINE1 SELP PLAT MTHFR F2
25 vein disease 28.8 VEGFA SERPINE1 PLAT MTHFR ICAM1 F2
26 tetralogy of fallot 28.8 VEGFA MTHFR MMP9 CRP
27 peripheral vascular disease 28.8 VEGFA VCAM1 TIMP1 SERPINE1 SELP PLAT
28 body mass index quantitative trait locus 11 28.7 VEGFA VCAM1 SERPINE1 SELL ICAM1 CRP
29 arteriosclerosis 28.6 VCAM1 TIMP1 SERPINE1 SELP MMP9 ITGAL
30 cerebrovascular disease 27.5 VCAM1 SERPINE1 SELP SELL PLAT MTHFR
31 venous insufficiency 27.4 VEGFA VCAM1 TIMP1 TGFB1 SERPINE1 SELP
32 vascular disease 26.9 VEGFA VCAM1 TIMP1 TGFB1 SERPINE1 SELP
33 diabetes mellitus 26.1 VEGFA VCAM1 TGFB1 SERPINE1 SELP SELL
34 fibrinolytic defect 10.5 SERPINE1 PLAT
35 autoimmune inner ear disease 10.5 TIMP1 MMP9
36 central serous chorioretinopathy 10.4 SERPINE1 PLAT
37 hydrops, lactic acidosis, and sideroblastic anemia 10.4
38 plasminogen activator inhibitor-1 deficiency 10.4 SERPINE1 PLAT
39 toxicodendron dermatitis 10.4 SELL ICAM1
40 dermatitis 10.4
41 dic in newborn 10.4 SERPINE1 F2
42 lichen planus 10.4 ITGAM ITGAL ICAM1
43 autoimmune enteropathy 10.4 ITGAL ICAM1
44 inflammatory bowel disease 14 10.4 TIMP1 SERPINE1 ICAM1
45 cardiac tuberculosis 10.4 SERPINE1 CRP
46 dowling-degos disease 1 10.4
47 shwartzman phenomenon 10.3 VCAM1 ITGAM ICAM1
48 pyridoxine deficiency anemia 10.3 VCAM1 F2
49 crescentic glomerulonephritis 10.3 VCAM1 SERPINE1 ICAM1
50 arthus reaction 10.3 SELP SELL ICAM1

Graphical network of the top 20 diseases related to Chronic Venous Insufficiency:



Diseases related to Chronic Venous Insufficiency

Symptoms & Phenotypes for Chronic Venous Insufficiency

MGI Mouse Phenotypes related to Chronic Venous Insufficiency:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.37 CRP F2 ICAM1 ITGA4 MMP12 MMP9
2 homeostasis/metabolism MP:0005376 10.36 CRP F2 ICAM1 ITGAL ITGAM MMP1
3 hematopoietic system MP:0005397 10.34 F2 ICAM1 ITGA4 ITGAL ITGAM MMP12
4 immune system MP:0005387 10.32 CRP F2 ICAM1 ITGA4 ITGAL ITGAM
5 growth/size/body region MP:0005378 10.23 F2 ICAM1 MMP9 MTHFR PLAT SELL
6 cellular MP:0005384 10.22 ICAM1 ITGA4 ITGAL ITGAM MMP9 PLAT
7 integument MP:0010771 10.06 F2 ICAM1 MMP12 MMP9 MTHFR PLAT
8 neoplasm MP:0002006 9.91 ICAM1 ITGAL MMP1 MMP9 SELL SERPINE1
9 nervous system MP:0003631 9.9 F2 ICAM1 ITGAM MMP12 MMP9 MTHFR
10 reproductive system MP:0005389 9.61 F2 MMP12 MMP9 MTHFR PLAT TGFB1
11 respiratory system MP:0005388 9.32 F2 MMP12 MMP9 PLAT SELL SELP

Drugs & Therapeutics for Chronic Venous Insufficiency

Drugs for Chronic Venous Insufficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Rivaroxaban Approved Phase 4 366789-02-8
3
Glucosamine Approved, Investigational Phase 4 3416-24-8 439213
4
Coumarin Experimental Phase 4 91-64-5 323
5
Troxerutin Investigational Phase 4 7085-55-4 5486699
6 Salicylates Phase 4
7 Heparinoids Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Hemostatics Phase 4
10 Aminaftone Phase 4
11 Coagulants Phase 4
12 HIV Protease Inhibitors Phase 4
13
protease inhibitors Phase 4
14 Serine Proteinase Inhibitors Phase 4
15 Antithrombin III Phase 4
16 Antithrombins Phase 4
17 Factor Xa Inhibitors Phase 4
18 Anticoagulants Phase 4
19 Anesthetics Phase 4
20 Fibrinolytic Agents Phase 4
21 Glucuronyl glucosamine glycan sulfate Phase 4
22 Hypolipidemic Agents Phase 4
23 Hypoglycemic Agents Phase 4
24 Antimetabolites Phase 4
25 Lipid Regulating Agents Phase 4
26
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
27
Polidocanol Approved Phase 3 9002-92-0
28
carbamide peroxide Approved Phase 2, Phase 3 124-43-6
29
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
30
Dalteparin Approved Phase 3 9005-49-6
31
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
32
tannic acid Approved Phase 3 1401-55-4
33
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
34
Becaplermin Approved, Investigational Phase 3 165101-51-9
35
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
36 Sclerosing Solutions Phase 3
37 Pharmaceutical Solutions Phase 3
38 calcium heparin Phase 3
39 Tin Fluorides Phase 3
40 Calcium, Dietary Phase 3
41 Heparin, Low-Molecular-Weight Phase 3
42 Carboxymethylcellulose Sodium Phase 3
43 Mitogens Phase 3
44 Angiogenesis Inducing Agents Phase 3
45 Grape Approved Phase 2
46
Sodium citrate Approved, Investigational Phase 1, Phase 2 68-04-2
47
Timolol Approved Phase 2 26839-75-8 33624 5478
48
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
49
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 65-23-6 1054
50
Citric acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 77-92-9 311

Interventional clinical trials:

(show top 50) (show all 108)
# Name Status NCT ID Phase Drugs
1 Evaluate the Efficacy and Safety of Esarin Gel in the Treatment of Chronic Venous Insufficiency or Varicose Vein Combine With Superficial Vein Thrombophlebitis in Outpatient Completed NCT02346058 Phase 4 Esarin Gel
2 A 6-week, Open, Multicentre Safety Trial to Evaluate the Tolerability Profile of Antistax® Film Coated Tablets (Extr. Vitis Viniferae Siccum), 360 mg/Day Per os, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02184234 Phase 4 Antistax film coated tablets
3 Multicenter, Prospective, Randomized, Double-Blind Study to Assess the Therapeutic Efficacy and Safety of the Use of Venocur Triplex® in Patients With Chronic Venous Insufficiency Completed NCT00835822 Phase 4 Venocur Triplex®;placebo
4 Gliding Aids for Medical Compression Stockings - Practicability in Elderly Patients With Chronic Venous Insufficiency Completed NCT01432795 Phase 4
5 Evaluation of Efficacy and Safety of the Fixed-dose Combination of Coumarin and Troxerutin (Venalot®) Versus Placebo in the Symptomatic Treatment of Chronic Venous Insufficiency - VENACT Completed NCT01848210 Phase 4 Coumarin/troxerutin;Placebo
6 Randomized Double-blind Trial Between Clinical and Endovascular Treatment in Patients With Advanced Chronic Venous Insufficiency and Iliac Venous Obstruction Completed NCT02149212 Phase 4 Phlebotonic
7 Clinical Non-inferiority Study Between Diosmin 600 mg Tablets and Diosmin 900 mg + Hesperidin 100 mg Tablets in Symptomatic Chronic Venous Insufficiency After 6 Months of Treatment: Single-blind, Randomized, Parallel Group Study Completed NCT03471910 Phase 4 Diosmin;Diosmin / Hesperidin
8 Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein: A Prospective Randomized Trial Completed NCT02236338 Phase 4
9 The Effect of Neuromuscular Electrical Therapy on Pain in Patients With Venous Ulcers: a Controlled Clinical Trial Completed NCT01372020 Phase 4
10 Study of Antiinflammatory Effects of Detralex (Daflon) in Patients With Chronic Venous Disease Completed NCT01654016 Phase 4 Detralex
11 The Efficacy of Rivaroxaban With Diosmine in the Long-term Treatment of Acute Proximal Deep Vein Thrombosis Active, not recruiting NCT03413618 Phase 4 Rivaroxaban;Diosmin
12 Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein: A Prospective Randomized Trial Terminated NCT02248740 Phase 4
13 Prospective Evaluation of the Quality of Life of Patients With Post-thrombotic Syndrome Who Receive Compression Therapy and Sulodexide — SQUARES Study Terminated NCT02512601 Phase 4 Sulodexide
14 A Clinical Multicenter, Phase III, Prospective, Randomized, Double-blind, Comparative Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Venous Insufficiency When Compared With Daflon Unknown status NCT01477281 Phase 3 Daflon;Venaflon (Diosmin and Hesperidin)
15 Study Clinical, Multicenter,Phase III,Prospective,Randomized,Comparative Double Blind/Double-dummy to Assess the Efficacy and Tolerability of the Use of Varicell in Reducing the Symptoms Caused by Chronic Venous Insufficiency and Hemorrhoidal Syndrome When Compared With Daflon Unknown status NCT01321619 Phase 3 Daflon;Varicell placebo
16 A Comparative Study to Assess the Efficacy and Safety of Endolex Forte vs Diosmin and Hesperidin in Reducing the symptomatoLogy of Patients With ChronIc VeNous Insufficiency Between Functional Classes CEAP 1-4, During a Period of 6 Months Unknown status NCT02927483 Phase 3
17 Comparative Efficacy of Two Preparations of the Association Diosmin (450 mg) + Hesperidin (50 mg) in the Treatment of Chronic Venous Insufficiency (CVI) Unknown status NCT01110512 Phase 3 Flavonid;Daflon
18 Efficacy of Autologous Platelet-Rich Plasma in the Treatment of Vascular Ulcers in Primary Care: Clinical Trial Phase III Unknown status NCT02213952 Phase 3 Platelet-Rich Plasma
19 Randomized Single Center Comparative Study of the Treatment of Insufficient Greater Saphenous Vein: Surgery vs Ultrasound Guided Sclerotherapy With Foam and Endovenous Laser Therapy Unknown status NCT00529672 Phase 3
20 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax Film-coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency. Completed NCT00292435 Phase 3 Read vine leaf extract (AS 195)
21 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 360 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191254 Phase 3 Antistax®;Placebo
22 Prospective, Randomized and Explorative Controlled Study About Influences of Compression Stockings on Skin's Barrier Function at Patients With Chronic Venous Insufficiency Completed NCT00196443 Phase 2, Phase 3
23 A 12-week, Double-blind, Randomised, Placebo-controlled, Multicentre Trial to Evaluate Efficacy and Tolerability of Antistax® Film Coated Tablets, 720 mg/Day Orally, in Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT00855179 Phase 3 Red vine leaf extract (AS 195);Placebo
24 Crenobalneotherapy in the Treatment of Chronic Venous Insufficiency. A Randomized Clinical Trial. Completed NCT01956318 Phase 3
25 Efficacy on Volume Reduction and Tolerance of Progressiv' Medical Compressive Therapy (MCT) V0322 BC in Patients With Chronic Venous Oedema. International, Multicentric, Randomised, Controlled, Double Blind Study, in Two Parallel Groups v0322 bc Versus Placebo Completed NCT01402921 Phase 3
26 Evaluation of the Efficacy of Spa Treatment for Prevention of Leg Ulcers in Advanced Chronic Venous Insufficiency. Completed NCT00838500 Phase 3 Immediate spa treatment;Late spa treatment
27 Deep Venous Thrombosis. Long-Term Results After Treatment With Either Low-Molecular -Weight Heparin or Unfractionated Heparin. Examinations of the Venous System. Completed NCT00628576 Phase 3 unfractionated heparin;Tinzaparin (Leo)
28 Double Blind Randomized Controlled Trial of Recombinant Human Platelet Derived Growth Factor-BB Gel (Regranex Gel®) Versus Hydrogel (Duoderm Hydrogel®) for Healing of MARTORELL's Hypertensive Leg Ulcers. ERAN Trial. Completed NCT00970697 Phase 3 becaplermin gel;Duoderm Hydrogel™
29 The MUFFIN-PTS Trial: Micronized Purified Flavonoid Fraction for the Treatment of Post-Thrombotic Syndrome Not yet recruiting NCT03833024 Phase 3 Micronized Purified Flavonoid Fraction;Placebo
30 Clinical Evaluation of the Safety and Effectiveness of Topical Autologous Platelet Gel (APG) for the Treatment of Lower Extremity Chronic Venous Insufficiency Ulcers. A Multicenter, Randomized, Controlled Clinical Trial Withdrawn NCT00273234 Phase 3
31 A Prospective Double Blind Randomized Controlled Trial Of Electrocoagulation Versus Radiofrequency Treatment Of The Great Saphenous Vein In Patients With Varicose Veins. Unknown status NCT02139085 Phase 2
32 NON-HEALING ULCERS WITHOUT CRITICAL LIMB ISCHEMIA (NEWLI-Trial): A Single Center Pilot Trial on the Efficacy of an Endovascular Approach for Treatment of Non-healing Lower Limb Ulcers in Patients Presenting With a Mild to Moderate Peripheral Artery Disease Unknown status NCT01666093 Phase 2
33 A 17 Week, Randomised, Double-blind, Placebo Controlled Cross-over Trial to Evaluate the Efficacy of Antistax® Film Coated Tablets (Extr. Vitis Vinifera Siccum), 360 mg/Day p.o. in Improving Microcirculation of the Skin in the Leg of Male and Female Patients Suffering From Chronic Venous Insufficiency Completed NCT02191163 Phase 2 Antistax®;Placebo
34 The Ability of Antistax® to Improve Chronic Venous Insufficiency (CVI) I and II in Male and Female Patients: a Dose Response Study Completed NCT02191280 Phase 2 Antistax®, low dose;Antistax®, high dose;Placebo
35 Physical Conditioning in Management of Chronic Venous Insufficiency Completed NCT00013273 Phase 2
36 A Randomized, Parallel Group, Controlled Study to Assess the Efficacy and Safety of NMBM in the Treatment of Subjects With a Post-cellulitis and Venous Leg Ulcer Completed NCT01770509 Phase 1, Phase 2
37 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 on the Quality of Life in Females With Chronic Venous Insufficiency Completed NCT02498327 Phase 2
38 Topical Timolol Benefit in Venous Ulcers Completed NCT02422017 Phase 2 Timolol
39 Feasibility and Safety and Evaluation of the Potential Efficacy of Autologous Platelet-rich Plasma in the Treatment of Vascular Venous Ulcers Compared to Moist Wound Care in a Primary Care Setting Completed NCT01817218 Phase 1, Phase 2 Platelet Rich Plasma
40 The Efficacy of Red Vine Leaf Extract, Butcher's Broom, Horse Chestnut and Vitamin B6 in the Treatment of Symptoms Associated With Chronic Venous Insufficiency Completed NCT02483962 Phase 2
41 An Open Label Multicenter Safety Study of the Varisolve® Procedure for the Treatment of Varicose Veins in Patients With Right-to-left Cardiac Shunt Completed NCT00442364 Phase 2 Polidocanol (1%) Microfoam (Varisolve)
42 Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers: a Two-arm, Double-blind, Placebo-controlled, Randomized Controlled Trial. Recruiting NCT03154619 Phase 2 0.1% TR 987;Placebo gel
43 Double Blind Randomized Clinical Trial Comparing Pycnogenol Versus Placebo for Pigmentation Prevention After Treatment With Varicose Veins With Foam Sclerotherapy Not yet recruiting NCT04203043 Phase 2 Pycnogenol Oral Product
44 A Phase 1a, Open Label, Single Dose, Dose Response, Pilot Study to Evaluate the Safety and Tolerability of Human Fibroblast Growth Factor-1 (FGF-1) in Normal Volunteers Given Punch Skin Biopsies Unknown status NCT00916292 Phase 1 FGF-1 141;FGF-1 141
45 Study on the Effect of Kinesio Taping on Bioelectrical Activity of Gastrocnemius Muscles and Range of Ankle Motion in Post-menopausal Women With Chronic Venous Insufficiency Completed NCT01501188 Phase 1
46 Phase I Open-label, First-in-human Study to Evaluate Feasibility and Safety of Tissue Engineered Veins in Patients With Chronic Venous Insufficiency Not yet recruiting NCT03784131 Phase 1 P-TEV
47 The Clinical Research of Surgery on Primary Chronic Venous Insufficiency Unknown status NCT00931424
48 Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Persons and Patients With Chronic Venous Disease as a New Non Invasive Method for Investigation of the Pathophysiology in Primary Varicose Veins Unknown status NCT01000909
49 Safety and Primary Efficacy of the External Synchronized Vein Valve (ESVV) in Treatment of Chronic Venous Insufficiency (CVI) Sequel - A Pilot Study Unknown status NCT01346553
50 Prospective, Single-arm, Single Center, Pilot Study of Vascular Ultrasound Imaging Used as an Adjunct to Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction Unknown status NCT02240914

Search NIH Clinical Center for Chronic Venous Insufficiency

Genetic Tests for Chronic Venous Insufficiency

Anatomical Context for Chronic Venous Insufficiency

MalaCards organs/tissues related to Chronic Venous Insufficiency:

40
Skin, Endothelial, Testes, Liver, Heart, Bone, Monocytes

Publications for Chronic Venous Insufficiency

Articles related to Chronic Venous Insufficiency:

(show top 50) (show all 2595)
# Title Authors PMID Year
1
Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. 54 61
15191401 2004
2
[Cytochromes P450, vascular tone varicosis]. 54 61
12843956 2003
3
[Changes in VCAM-1 cell adhesion molecule after phlebologic thermal care in chronic venous insufficiency of the lower limbs]. 54 61
11917667 2001
4
Expression of the adhesion molecules ICAM-1, VCAM-1, LFA-1 and VLA-4 in the skin is modulated in progressing stages of chronic venous insufficiency. 54 61
10086854 1999
5
Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. 54 61
8609252 1996
6
Endovascular stenting for chronic femoro-iliac venous obstructive disease: Clinical efficacy and short-term outcomes. 61
31036535 2020
7
[Innovations in medical compression therapy]. 61
31845297 2019
8
Pivotal Study of Endovenous Stent Placement for Symptomatic Iliofemoral Venous Obstruction. 61
31833414 2019
9
Etiology of iliocaval stent thrombosis. 61
31843484 2019
10
Surgical resection for suppurative thrombophlebitis of the great saphenous vein after radiofrequency ablation. 61
31799481 2019
11
[Pros and cons of classic crossectomy with stripping compared to endoluminal treatment : Competition or team play?] 61
31807791 2019
12
Clinical response to combination therapy in the treatment of varicose veins. 61
31843482 2019
13
Chronic venous insufficiency: A review for nurses. 61
31764871 2019
14
Chronic venous insufficiency: A review for nurses. 61
31658230 2019
15
Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial. 61
31818694 2019
16
Klippel-Trénaunay syndrome: a case report of a rare vascular disorder identified in a rural Canadian hospital. 61
31721594 2019
17
Treatment of Elephantiasis Nostras Verrucosa with CO2 Laser. 61
31807453 2019
18
A critical review on the three-dimensional finite element modelling of the compression therapy for chronic venous insufficiency. 61
31319767 2019
19
Ulcers in leprosy patients, an unrecognized clinical manifestation: a report of 8 cases. 61
31783808 2019
20
Assessment and grading of pigmentation in chronic venous insufficiency. 61
31699007 2019
21
Limitations of VEINES QOL/SYM for discriminating chronic venous insufficiency severity. 61
31839797 2019
22
Medical compression stockings on the skin moisture in patients with chronic venous disease. 61
31364497 2019
23
Sulodexide Improves Contraction and Decreases Matrix Metalloproteinase-2 and -9 in Veins under Prolonged Stretch. 61
31738197 2019
24
Contemporary management of lower extremity venous aneurysms. 61
31495768 2019
25
The intravascular ultrasound morphometry of iliac veins in subjects without severe chronic venous insufficiency and its implications for treatment indications and stent size selection. 61
31645193 2019
26
Influence of polidocanol ultrasound-guided foam sclerotherapy on quality of life in lower extremity chronic venous disease: initial results. 61
31673252 2019
27
Exploration of robotic-assisted surgical techniques in vascular surgery. 61
30610536 2019
28
Expression profile of tRNA‑derived fragments and their potential roles in human varicose veins. 61
31432124 2019
29
Development of a Minimum Data Set Registry for Chronic Venous Insufficiency of the Lower Limbs. 61
31653084 2019
30
Chronic Venous Insufficiency Causing a Diagnostic Conundrum on Tc-99m Bone Scan Done for Osteosarcoma Surveillance: Awareness is the Key! 61
31579187 2019
31
Hemorrhoidal disease and chronic venous insufficiency: Concomitance or coincidence; results of the CHORUS study (Chronic venous and HemORrhoidal diseases evalUation and Scientific research). 61
31512275 2019
32
Vascular training does matter in the outcomes of saphenous high ligation and stripping. 61
31068278 2019
33
Efficacy of balloon venoplasty alone in the correction of nonthrombotic iliac vein lesions. 61
31176659 2019
34
Tissue-engineered transcatheter vein valve. 61
31195302 2019
35
Appropriate Surgical Treatment of Symptomatic Primary Varicose Veins Decreases Systemic Inflammatory Biomarkers. 61
31636748 2019
36
Endovenous cyanoacrylate glue to treat varicose veins and chronic venous insufficiency-Experience gained from our first 100+ truncal venous ablations in a multi-ethnic Asian population using the Medtronic VenaSeal™ Closure System. 61
30691376 2019
37
Overview of venous pathology related to repetitive vascular trauma in athletes. 61
31231058 2019
38
Mechanochemical ablation as an alternative to venous ulcer healing compared with thermal ablation. 61
31421838 2019
39
Venous Ulcers: Diagnosis and Treatment. 61
31478635 2019
40
A Study of Risk Factors of Chronic Venous Insufficiency and its Association with Features Suggestive of Preceding or Present Deep Venous Thrombosis. 61
31543530 2019
41
Impact of Great Saphenous Vein Foam Sclerotherapy on Quality of Life and Photoplethysmography Findings in Chronic Venous Insufficiency: One-Year Follow-up. 61
31397782 2019
42
Influence of linear intravenous energy density on the success of intravenous laser ablation for treatment of chronic venous insufficiency. 61
31497034 2019
43
Histopathological changes to the vascular wall after treatment of great saphenous veins using n-butyl-2-cyanoacrylate. 61
31063085 2019
44
Ablation therapy with cyanoacrylate glue and laser for refluxing great saphenous veins - a prospective randomised study. 61
31014200 2019
45
One-Year Results of Iliocaval Stenting. 61
30826434 2019
46
The influence of May-Thurner syndrome on post-thrombotic syndrome in young women. 61
30848698 2019
47
Scientific Papers and Patents on Substances with Unproven Effects. Part 2. 61
31424374 2019
48
High tolerance of progressive elastic compression in peripheral arterial disease. 61
31159678 2019
49
Balneotherapy for chronic venous insufficiency. 61
31449319 2019
50
Chronic venous insufficiency and venous microangiopathy: management with compression and Pycnogenol®. 61
31347820 2019

Variations for Chronic Venous Insufficiency

Expression for Chronic Venous Insufficiency

Search GEO for disease gene expression data for Chronic Venous Insufficiency.

Pathways for Chronic Venous Insufficiency

Pathways related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.04 VEGFA VCAM1 TIMP2 TIMP1 TGFB1 SELL
2
Show member pathways
13.72 VEGFA TIMP2 TIMP1 TGFB1 MMP9 MMP12
3
Show member pathways
13.56 VEGFA TIMP2 TIMP1 TGFB1 ITGAM ITGAL
4
Show member pathways
13.38 VEGFA VCAM1 TIMP1 TGFB1 MMP9 MMP1
5
Show member pathways
13.35 VEGFA VCAM1 TGFB1 SERPINE1 MMP9 MMP12
6
Show member pathways
13.18 VEGFA TIMP1 TGFB1 SERPINE1 SELP SELL
7
Show member pathways
13.07 TIMP2 TIMP1 TGFB1 ITGAM ITGAL ITGA4
8
Show member pathways
12.86 VEGFA TGFB1 PLAT MMP9 ITGAM
9
Show member pathways
12.85 VEGFA TGFB1 ITGAL ITGA4 ICAM1
10 12.83 VEGFA TGFB1 MMP9 MMP1 F2
11
Show member pathways
12.66 VEGFA VCAM1 MMP9 ITGAM ITGAL ITGA4
12
Show member pathways
12.44 TIMP2 TIMP1 TGFB1 ITGAM ITGAL ITGA4
13
Show member pathways
12.36 SERPINE1 PLAT MTHFR ICAM1 F2 CRP
14
Show member pathways
12.24 VEGFA TIMP1 SERPINE1 MMP1
15 12.24 VEGFA TGFB1 MMP9 MMP12 MMP1
16
Show member pathways
12.21 VCAM1 ITGAM ITGAL ITGA4 ICAM1
17 12.15 VEGFA VCAM1 PLAT MMP9 ICAM1
18 12.14 SERPINE1 PLAT ITGAM F2
19 12.13 VCAM1 SELL ITGAL ITGA4 ICAM1
20
Show member pathways
12.11 TGFB1 SELP SELL MMP1 ITGAM ITGAL
21
Show member pathways
12.08 PLAT MMP9 ITGAM F2
22 12.08 VCAM1 SERPINE1 MMP9 ITGA4 ICAM1
23 12.08 VCAM1 SELP SELL ITGAM ITGAL ITGA4
24 12.06 TGFB1 SELP MMP9 MMP12 ICAM1
25
Show member pathways
12.05 VCAM1 TIMP2 TIMP1 TGFB1 SERPINE1 MMP9
26 11.97 VEGFA VCAM1 TGFB1 SERPINE1 ICAM1
27
Show member pathways
11.95 TIMP2 TIMP1 MMP9 MMP12 MMP1
28 11.94 SELP ITGAM ITGAL ICAM1
29 11.9 TIMP2 TIMP1 TGFB1 MMP9
30 11.89 VEGFA TGFB1 MMP1 ITGAL ICAM1
31 11.82 ITGAM ITGAL ITGA4
32 11.78 TIMP2 TIMP1 TGFB1 ITGAM ITGAL ITGA4
33 11.75 TGFB1 SELL ITGAM
34 11.74 VEGFA MMP9 MMP1
35 11.74 VEGFA TGFB1 PLAT MMP9
36
Show member pathways
11.71 VEGFA VCAM1 MMP9 MMP1 ICAM1
37 11.67 TIMP1 TGFB1 MMP9
38 11.61 VEGFA VCAM1 TIMP1 TGFB1 MMP9 MMP1
39 11.59 VCAM1 TGFB1 SELP ITGAL ICAM1
40 11.58 VEGFA TGFB1 MMP1
41 11.56 VEGFA TGFB1 PLAT
42 11.56 SELP PLAT MMP9 ITGAM ICAM1
43 11.52 TGFB1 ITGAM ITGAL
44
Show member pathways
11.51 VCAM1 ITGAL ITGA4
45 11.5 VCAM1 ITGAM ITGAL ITGA4 ICAM1
46 11.49 TIMP2 TIMP1 SERPINE1 PLAT MMP9 MMP12
47 11.47 TIMP2 SELL MMP9 MMP1
48
Show member pathways
11.32 VEGFA TIMP1 CRP
49 11.21 VEGFA TIMP2 MMP9
50 11.2 TIMP2 TIMP1 MMP9 ICAM1 F2

GO Terms for Chronic Venous Insufficiency

Cellular components related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.13 VCAM1 TIMP1 SERPINE1 PLAT MMP9 ITGAM
2 extracellular region GO:0005576 10.11 VEGFA TIMP2 TIMP1 TGFB1 SERPINE1 PLAT
3 external side of plasma membrane GO:0009897 9.88 VCAM1 SELP SELL ITGAM ICAM1 F2
4 collagen-containing extracellular matrix GO:0062023 9.8 TIMP2 TGFB1 SERPINE1 PLAT MMP9 ICAM1
5 extracellular matrix GO:0031012 9.7 VEGFA TIMP2 TIMP1 TGFB1 MMP9 MMP12
6 integrin complex GO:0008305 9.63 ITGAM ITGAL ITGA4
7 platelet alpha granule lumen GO:0031093 9.62 VEGFA TIMP1 TGFB1 SERPINE1
8 cell surface GO:0009986 9.61 VEGFA VCAM1 TIMP2 TGFB1 PLAT ITGAM
9 extracellular space GO:0005615 9.47 VEGFA VCAM1 TIMP2 TIMP1 TGFB1 SERPINE1

Biological processes related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.04 VCAM1 SELP SELL ITGAM ITGAL ITGA4
2 neutrophil degranulation GO:0043312 10.03 TIMP2 SELL MMP9 ITGAM ITGAL
3 aging GO:0007568 9.92 VCAM1 TIMP2 TIMP1 TGFB1
4 positive regulation of protein phosphorylation GO:0001934 9.92 VEGFA TGFB1 MMP9 F2
5 regulation of immune response GO:0050776 9.92 VCAM1 SELL ITGAL ITGA4 ICAM1
6 response to hypoxia GO:0001666 9.88 VEGFA VCAM1 TGFB1 PLAT MTHFR ICAM1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 VEGFA TGFB1 ICAM1
8 response to organic substance GO:0010033 9.83 TIMP2 TIMP1 TGFB1
9 platelet degranulation GO:0002576 9.83 VEGFA TIMP1 TGFB1 SERPINE1 SELP
10 cellular response to amyloid-beta GO:1904646 9.77 VCAM1 ITGA4 ICAM1
11 extracellular matrix disassembly GO:0022617 9.77 TIMP2 TIMP1 MMP9 MMP12 MMP1
12 collagen catabolic process GO:0030574 9.76 MMP9 MMP12 MMP1
13 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.76 VCAM1 SELP ITGAL ICAM1
14 cytokine-mediated signaling pathway GO:0019221 9.76 VEGFA VCAM1 TIMP1 TGFB1 MMP9 MMP1
15 positive regulation of protein complex assembly GO:0031334 9.74 VEGFA TGFB1 MMP1
16 negative regulation of proteolysis GO:0045861 9.72 TIMP2 PLAT F2
17 fibrinolysis GO:0042730 9.71 SERPINE1 PLAT F2
18 positive regulation of superoxide anion generation GO:0032930 9.69 TGFB1 ITGAM CRP
19 positive regulation of vascular permeability GO:0043117 9.65 VEGFA TGFB1
20 positive regulation of leukocyte migration GO:0002687 9.65 VEGFA SELP ITGA4
21 leukocyte cell-cell adhesion GO:0007159 9.65 VCAM1 SELP ITGAL ITGA4 ICAM1
22 cell activation GO:0001775 9.64 TIMP1 TGFB1
23 negative regulation of fibrinolysis GO:0051918 9.64 SERPINE1 F2
24 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.63 TIMP2 TIMP1
25 leukocyte tethering or rolling GO:0050901 9.62 VCAM1 SELP SELL ITGA4
26 negative regulation of metallopeptidase activity GO:1905049 9.61 TIMP2 TIMP1
27 membrane to membrane docking GO:0022614 9.61 VCAM1 ICAM1
28 extracellular matrix organization GO:0030198 9.61 VCAM1 SERPINE1 MMP9 MMP12 MMP1 ITGAM
29 connective tissue replacement involved in inflammatory response wound healing GO:0002248 9.6 TIMP1 TGFB1
30 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 9.58 ITGAL ICAM1
31 cell-cell adhesion in response to extracellular stimulus GO:0140039 9.56 VCAM1 ITGA4
32 leukocyte migration GO:0050900 9.28 TGFB1 SELP SELL MMP1 ITGAM ITGAL

Molecular functions related to Chronic Venous Insufficiency according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 10.14 TIMP2 TIMP1 SELP SELL MMP9 MMP12
2 peptidase activity GO:0008233 9.89 PLAT MMP9 MMP12 MMP1 F2
3 protein heterodimerization activity GO:0046982 9.83 VEGFA TGFB1 ITGAM ITGAL ITGA4
4 heparin binding GO:0008201 9.67 VEGFA SELP SELL F2
5 endopeptidase activity GO:0004175 9.65 MMP9 MMP12 MMP1
6 growth factor activity GO:0008083 9.56 VEGFA TIMP1 TGFB1 F2
7 oligosaccharide binding GO:0070492 9.46 SELP SELL
8 serine-type endopeptidase activity GO:0004252 9.46 PLAT MMP9 MMP1 F2
9 glycosphingolipid binding GO:0043208 9.32 SELP SELL
10 protease binding GO:0002020 9.26 TIMP2 TIMP1 SERPINE1 SELL
11 cell adhesion molecule binding GO:0050839 8.92 VCAM1 SELL ITGAL ITGA4

Sources for Chronic Venous Insufficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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