MCID: CHR415
MIFTS: 38

Chronic Venous Leg Ulcers

Aliases & Classifications for Chronic Venous Leg Ulcers

MalaCards integrated aliases for Chronic Venous Leg Ulcers:

Name: Chronic Venous Leg Ulcers 39 56

Summaries for Chronic Venous Leg Ulcers

MalaCards based summary : Chronic Venous Leg Ulcers is related to lymphoma, large-cell, immunoblastic and lung giant cell carcinoma. An important gene associated with Chronic Venous Leg Ulcers is TIMP1 (TIMP Metallopeptidase Inhibitor 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Gastrointestinal Agents and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Chronic Venous Leg Ulcers

Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 lymphoma, large-cell, immunoblastic 10.2 MYC TIMP1
2 lung giant cell carcinoma 10.1 MYC TIMP1
3 chronic venous insufficiency 10.1
4 venous insufficiency 10.1
5 thrombophilia 10.1
6 suppressor of tumorigenicity 3 10.1 BAX MYC
7 alk-negative anaplastic large cell lymphoma 10.1 BAX MYC
8 kashin-beck disease 10.0 BAX FAS
9 leukocyte disease 10.0 BAX MYC
10 dermatitis, atopic 9.9
11 reflex sympathetic dystrophy 9.9
12 algoneurodystrophy 9.9
13 post-thrombotic syndrome 9.9
14 dermatitis 9.9
15 pyoderma 9.9
16 pyoderma gangrenosum 9.9
17 rapidly involuting congenital hemangioma 9.9
18 type ii mixed cryoglobulinemia 9.8 FAS FASLG
19 lymphocytic gastritis 9.8 FAS FASLG
20 precursor t-cell acute lymphoblastic leukemia 9.8 BAX MYC
21 acute t cell leukemia 9.8 BAX FASLG
22 lymphomatoid papulosis 9.8 FAS FASLG
23 acute myocarditis 9.8 FAS FASLG
24 fuchs' endothelial dystrophy 9.8 BAX FASLG
25 epstein-barr virus-associated gastric carcinoma 9.8 FAS FASLG
26 silicosis 9.8 FAS FASLG
27 severe cutaneous adverse reaction 9.8 FAS FASLG
28 breast adenocarcinoma 9.7 BAX FAS MYC
29 pneumoconiosis 9.7 FAS FASLG
30 b-cell lymphomas 9.7 BAX FAS MYC
31 burkitt lymphoma 9.7 BAX FAS MYC
32 lymphoma, non-hodgkin, familial 9.7 BAX FAS MYC
33 lymphopenia 9.7 FAS FASLG
34 graft-versus-host disease 9.7 FAS FASLG
35 viral hepatitis 9.7 FAS FASLG
36 large intestine cancer 9.6 FASLG MYC TIMP1
37 lymphoproliferative syndrome 9.6 FAS FASLG
38 central nervous system tuberculosis 9.6 FAS FASLG TIMP1
39 cartilage-hair hypoplasia 9.5 BAX FAS FASLG
40 esophageal cancer 9.4 BAX FASLG MYC TIMP1
41 gastric adenocarcinoma 9.3 BAX FAS FASLG MYC
42 ewing sarcoma 9.2 FAS FASLG MYC
43 lung cancer 9.0 BAX FAS FASLG MYC TIMP1
44 colorectal cancer 9.0 BAX FAS FASLG MYC TIMP1

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to Chronic Venous Leg Ulcers

Symptoms & Phenotypes for Chronic Venous Leg Ulcers

GenomeRNAi Phenotypes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.26 FAS FASLG MYC TIMP1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.1 BAX FAS
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.1 BAX FAS FASLG MYC

MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.8 BAX FAS FASLG MYC TIMP1
2 hematopoietic system MP:0005397 9.77 BAX FAS FASLG MYC TIMP1
3 neoplasm MP:0002006 9.65 BAX FAS FASLG MYC TIMP1
4 limbs/digits/tail MP:0005371 9.62 BAX FAS MYC TIMP1
5 reproductive system MP:0005389 9.55 BAX FAS FASLG MYC TIMP1
6 respiratory system MP:0005388 9.26 BAX FAS FASLG TIMP1
7 skeleton MP:0005390 9.02 BAX FAS FASLG MYC TIMP1

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Drugs for Chronic Venous Leg Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gastrointestinal Agents Phase 4
2 Cathartics Phase 4
3 Laxatives Phase 4
4 Carboxymethylcellulose Sodium Phase 4
5
Thrombin Approved, Investigational Phase 3
6 Hemostatics Phase 3
7 Pharmaceutical Solutions Phase 3
8 Coagulants Phase 3
9
Mecasermin Approved, Investigational Phase 2 68562-41-4
10 Mitogens Phase 1, Phase 2,Phase 2
11 Anti-Bacterial Agents Phase 2
12 Anti-Infective Agents Phase 2
13 Somatomedin B Phase 2
14 insulin Phase 2
15 Insulin, Globin Zinc Phase 2
16
Mineral oil Approved, Vet_approved Not Applicable 8042-47-5
17
Ibuprofen Approved Not Applicable 15687-27-1 3672
18
Monensin Experimental, Vet_approved Not Applicable 17090-79-8
19 Omega 3 Fatty Acid Not Applicable
20 Emollients Not Applicable
21 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
2 TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers Terminated NCT02936128 Phase 4
3 Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers Unknown status NCT02130310 Phase 3
4 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
5 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
6 Phase I/II Dose Ranging CHRONSEAL® Study in Venous Leg Ulcers Unknown status NCT00797706 Phase 1, Phase 2 CHRONSEAL
7 EASH Dressing on Chronic Venous Leg Ulcers Completed NCT01497210 Phase 2
8 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
9 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
10 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers Completed NCT00825760 Phase 2 Topical PPA904 gel and light;Topical placebo gel plus light
11 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
12 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers Active, not recruiting NCT02973893 Phase 2
13 Silica Gel Fiber Wound Dressing for Chronic Venous Leg Ulcers Terminated NCT00998673 Phase 2
14 A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers Terminated NCT02154087 Phase 2
15 Cell Therapy for Venous Leg Ulcers Pilot Study Completed NCT01750749 Phase 1
16 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers Completed NCT01754506 Not Applicable
17 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers Completed NCT00628004 Not Applicable
18 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers Completed NCT00627094 Not Applicable
19 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers Completed NCT01671748 Not Applicable
20 Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers Recruiting NCT03589586 Not Applicable
21 Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy Recruiting NCT03716167 Not Applicable
22 Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers Recruiting NCT03629236 Not Applicable
23 Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing Recruiting NCT02024243
24 VLU Non-inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-layer Bandaging Active, not recruiting NCT02680834 Not Applicable
25 Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults Not yet recruiting NCT03576989 Not Applicable
26 Intermittent Pneumatic Compression of the Foot vs Geko Plus R-2 Neuromuscular Electrostimulation Device in Venous Leg Ulcer Patients Withdrawn NCT02912858 Not Applicable

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf�, skin substitute for chronic venous leg ulcers and diabetic foot ulcers
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf�) PMIDs: 12055943 12463767 20849380 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

42
Skin, Testes, Neutrophil

Publications for Chronic Venous Leg Ulcers

Articles related to Chronic Venous Leg Ulcers:

(show top 50) (show all 128)
# Title Authors Year
1
Prospective study of cryopreserved placental tissue wound matrix in the management of chronic venous leg ulcers. ( 30621916 )
2019
2
Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms. ( 30864220 )
2019
3
Trichloroacetic acid (80%) as a chemical debridement method for chronic venous leg ulcers-A pilot study. ( 29334174 )
2018
4
Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results. ( 29593807 )
2018
5
The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial. ( 30129080 )
2018
6
Reliability and Measurement Error of Digital Planimetry for the Measurement of Chronic Venous Leg Ulcers. ( 28922511 )
2017
7
Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. ( 28834103 )
2017
8
EPAa88+a88DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. ( 28758717 )
2017
9
Comparison of Efficacy of Autologous Platelet-rich Fibrin versus Saline Dressing in Chronic Venous Leg Ulcers: A Randomised Controlled Trial. ( 28529414 )
2017
10
Unna boot central gauze technique for chronic venous leg ulcers. ( 28329467 )
2017
11
Phase 3 Evaluation of HP802-247 in the Treatment of Chronic Venous Leg Ulcers. ( 27495869 )
2016
12
Estimating the Clinical Outcomes and Cost Differences Between Standard Care With and Without Cadexomer Iodine in the Management of Chronic Venous Leg Ulcers Using a Markov Model. ( 27356144 )
2016
13
Healing of Recalcitrant Chronic Venous Leg Ulcers by Punch Grafts Harvested From the Scalp. ( 26262948 )
2015
14
Medical grade honey in the management of chronic venous leg ulcers. ( 26050953 )
2015
15
Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. ( 26408463 )
2015
16
Randomized, controlled study of innovative spray formulation containing ozonated oil and I+-bisabolol in the topical treatment of chronic venous leg ulcers. ( 26280699 )
2015
17
Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100A cm(2)) chronic venous leg ulcers. ( 25595397 )
2015
18
Nutritional profile of older adults with chronic venous leg ulcers: AA pilot study. ( 26141998 )
2015
19
Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. ( 26095122 )
2015
20
Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. ( 24618232 )
2014
21
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343393 )
2014
22
Cost-Effective Use of Silver Dressings for the Treatment of Hard-to-Heal Chronic Venous Leg Ulcers. ( 24945381 )
2014
23
The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial. ( 25072595 )
2014
24
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort. ( 24937814 )
2014
25
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. ( 24839984 )
2014
26
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. ( 25300315 )
2014
27
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. ( 25498775 )
2014
28
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. ( 24635169 )
2014
29
Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. ( 25492574 )
2014
30
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(Ar) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). ( 24666170 )
2014
31
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343392 )
2014
32
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. ( 25351907 )
2014
33
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. ( 24589044 )
2014
34
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. ( 25382133 )
2014
35
The impact of chronic venous leg ulcers: a systematic review. ( 25492276 )
2014
36
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. ( 23998779 )
2013
37
Neutrophil activity in chronic venous leg ulcers--a target for therapy? ( 23551462 )
2013
38
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. ( 22833505 )
2013
39
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. ( 23118301 )
2013
40
Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: A 6-month follow-up. ( 23927847 )
2013
41
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. ( 22422794 )
2013
42
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. ( 24072751 )
2013
43
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. ( 23531093 )
2013
44
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. ( 22018697 )
2012
45
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. ( 22150832 )
2012
46
Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. ( 22863328 )
2012
47
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACELAr Ag and UrgotulAr Silver dressing on healing of chronic venous leg ulcers. ( 22066961 )
2012
48
Chronic venous leg ulcers: the future of cell-based therapies. ( 22863327 )
2012
49
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. ( 22074592 )
2012
50
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. ( 22174074 )
2012

Variations for Chronic Venous Leg Ulcers

Expression for Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for Chronic Venous Leg Ulcers

Pathways related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.55 BAX FAS FASLG MYC TIMP1
2
Show member pathways
13.53 BAX FAS FASLG MYC TIMP1
3
Show member pathways
13.34 BAX FAS FASLG MYC TIMP1
4
Show member pathways
13.12 BAX FAS FASLG TIMP1
5
Show member pathways
13 BAX FAS FASLG TIMP1
6
Show member pathways
12.65 BAX FAS FASLG MYC
7
Show member pathways
12.65 BAX FAS FASLG MYC
8 12.51 FAS FASLG MYC
9 12.48 BAX FAS FASLG MYC
10
Show member pathways
12.45 BAX FAS FASLG
11
Show member pathways
12.44 BAX FAS FASLG MYC
12
Show member pathways
12.42 BAX FAS FASLG
13
Show member pathways
12.33 DDX39B FAS FASLG
14
Show member pathways
12.33 BAX MYC TIMP1
15
Show member pathways
12.23 BAX FAS FASLG MYC
16
Show member pathways
12.14 BAX FASLG MYC
17
Show member pathways
12.12 BAX FAS MYC
18
Show member pathways
12 BAX FAS FASLG
19 12 FAS FASLG MYC
20
Show member pathways
11.93 BAX FAS FASLG
21
Show member pathways
11.91 BAX FAS FASLG
22
Show member pathways
11.82 BAX MYC TIMP1
23 11.65 BAX MYC
24 11.64 BAX FASLG MYC
25 11.6 FASLG MYC TIMP1
26 11.59 BAX MYC
27
Show member pathways
11.48 FASLG MYC
28
Show member pathways
11.36 BAX FAS FASLG
29 11.35 FASLG MYC
30 11.29 BAX MYC
31 11.26 BAX MYC
32 11.25 FAS FASLG
33
Show member pathways
11.22 BAX FAS
34 11.2 BAX FAS FASLG
35 11.19 BAX FAS FASLG MYC
36 11.17 FAS FASLG
37 11.04 BAX MYC
39
Show member pathways
10.88 BAX MYC
40 10.84 BAX FAS FASLG
41 10.76 BAX FASLG TIMP1

GO Terms for Chronic Venous Leg Ulcers

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 FAS MYC TIMP1
2 positive regulation of cell proliferation GO:0008284 9.77 FASLG MYC TIMP1
3 positive regulation of apoptotic process GO:0043065 9.73 BAX FAS FASLG
4 cytokine-mediated signaling pathway GO:0019221 9.71 FASLG MYC TIMP1
5 positive regulation of translation GO:0045727 9.58 DDX39B MYC
6 cellular response to UV GO:0034644 9.58 BAX MYC
7 positive regulation of neuron apoptotic process GO:0043525 9.57 BAX FASLG
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.52 FAS FASLG
9 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.51 BAX FASLG
10 negative regulation of fibroblast proliferation GO:0048147 9.49 BAX MYC
11 response to gamma radiation GO:0010332 9.48 BAX MYC
12 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.46 FAS FASLG
13 response to growth factor GO:0070848 9.43 FASLG MYC
14 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 BAX FAS FASLG
15 positive regulation of DNA biosynthetic process GO:2000573 9.4 DDX39B MYC
16 apoptotic signaling pathway GO:0097190 9.33 BAX FAS FASLG
17 necroptotic signaling pathway GO:0097527 9.32 FAS FASLG
18 response to wounding GO:0009611 9.29 BAX
19 ovarian follicle development GO:0001541 9.25 BAX
20 extrinsic apoptotic signaling pathway GO:0097191 9.13 BAX FAS FASLG
21 hypothalamus development GO:0021854 9.07 BAX
22 retinal cell programmed cell death GO:0046666 8.62 BAX FASLG

Sources for Chronic Venous Leg Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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