Aliases & Classifications for Chronic Venous Leg Ulcers

MalaCards integrated aliases for Chronic Venous Leg Ulcers:

Name: Chronic Venous Leg Ulcers 38 55

Summaries for Chronic Venous Leg Ulcers

MalaCards based summary : Chronic Venous Leg Ulcers is related to chronic venous insufficiency and venous insufficiency. An important gene associated with Chronic Venous Leg Ulcers is TIMP1 (TIMP Metallopeptidase Inhibitor 1), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Carboxymethylcellulose Sodium and Cathartics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are Decreased Salmonella-containing vacuole maturation and cardiovascular system

Related Diseases for Chronic Venous Leg Ulcers

Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 29.5 ITGA4 MMP9 TIMP1
2 venous insufficiency 29.5 ITGA4 MMP9 TIMP1
3 autoimmune inner ear disease 10.2 MMP9 TIMP1
4 diabetic foot ulcers 10.2 MMP9 TIMP1
5 cryptogenic organizing pneumonia 10.2 MMP9 TIMP1
6 conjunctival nevus 10.2 MMP9 TIMP1
7 microcystic meningioma 10.2 MMP9 TIMP1
8 nasal cavity squamous cell carcinoma 10.2 MMP9 TIMP1
9 sorsby fundus dystrophy 10.2 MMP9 TIMP1
10 appendicitis 10.1 MMP9 TIMP1
11 inner ear disease 10.1 MMP9 TIMP1
12 pulmonary emphysema 10.1 MMP9 TIMP1
13 pediatric multiple sclerosis 10.1 ITGA4 MMP9
14 carotid artery disease 10.1 MMP9 TIMP1
15 bronchiolitis obliterans 10.1 MMP9 TIMP1
16 aortic disease 10.1 MMP9 TIMP1
17 varicose veins 10.1 MMP9 TIMP1
18 inguinal hernia 10.1 MMP9 TIMP1
19 aging 10.1
20 photokeratitis 10.0 FASLG MMP9
21 aortic aneurysm, familial abdominal, 1 10.0 MMP9 TIMP1
22 relapsing-remitting multiple sclerosis 10.0 MMP9 TIMP1
23 lymphoma, large-cell, immunoblastic 10.0 MYC TIMP1
24 thrombophilia 10.0
25 kawasaki disease 9.9 MMP9 TIMP1
26 periodontitis 9.8 MMP9 TIMP1
27 dermatitis, atopic 9.8
28 reflex sympathetic dystrophy 9.8
29 algoneurodystrophy 9.8
30 squamous cell carcinoma 9.8
31 post-thrombotic syndrome 9.8
32 dermatitis 9.8
33 malignant histiocytosis 9.8 LTA MYC
34 bile duct carcinoma 9.7 FASLG MYC
35 demyelinating disease 9.7 ITGA4 MMP9
36 central nervous system tuberculosis 9.6 FASLG MMP9 TIMP1
37 male reproductive organ cancer 9.6 MMP9 MYC
38 pulmonary fibrosis, idiopathic 9.6 FASLG MMP9 TIMP1
39 female reproductive organ cancer 9.6 MMP9 MYC
40 respiratory system cancer 9.5 MMP9 MYC
41 cell type cancer 9.4 MMP9 MYC
42 interstitial lung disease 9.4 MMP9 TIMP1
43 gastrointestinal system cancer 9.3 MMP9 MYC
44 lung giant cell carcinoma 9.3 MMP9 MYC TIMP1
45 gastric adenocarcinoma 9.0 FASLG MMP9 MYC
46 multiple sclerosis 9.0 ITGA4 LTA MMP9 TIMP1
47 myocardial infarction 9.0 LTA MMP9 TIMP1
48 esophageal cancer 8.9 FASLG MMP9 MYC
49 ewing sarcoma 8.8 FASLG MMP9 MYC

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to Chronic Venous Leg Ulcers

Symptoms & Phenotypes for Chronic Venous Leg Ulcers

GenomeRNAi Phenotypes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Salmonella-containing vacuole maturation GR00133-A-2 8.62 ITGA4 MYC

MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 MYC FASLG TIMP1 ITGA4 LTA MMP9
2 hematopoietic system MP:0005397 9.88 MYC FASLG TIMP1 ITGA4 LTA MMP9
3 immune system MP:0005387 9.85 MYC FASLG TIMP1 ITGA4 LTA MMP9
4 mortality/aging MP:0010768 9.73 MMP9 MYC FASLG ITGA4 TIMP1 LTA
5 limbs/digits/tail MP:0005371 9.62 MMP9 MYC TIMP1 LTA
6 neoplasm MP:0002006 9.46 MMP9 MYC FASLG TIMP1
7 respiratory system MP:0005388 9.26 MMP9 FASLG TIMP1 LTA
8 skeleton MP:0005390 9.02 MYC FASLG TIMP1 LTA MMP9

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Drugs for Chronic Venous Leg Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4
2 Cathartics Phase 4
3 Gastrointestinal Agents Phase 4
4 Laxatives Phase 4
5
Thrombin Approved, Investigational Phase 3
6 Coagulants Phase 3
7 Hemostatics Phase 3
8 Pharmaceutical Solutions Phase 3
9 Mitogens Phase 1, Phase 2,Phase 2
10 Anti-Bacterial Agents Phase 2
11 Anti-Infective Agents Phase 2
12 insulin Phase 2
13 Insulin, Globin Zinc Phase 2
14 Somatomedin B Phase 2
15
Mineral oil Approved, Vet_approved Not Applicable 8042-47-5
16
Ibuprofen Approved Not Applicable 15687-27-1 3672
17 monensin Not Applicable
18 Omega 3 Fatty Acid Nutraceutical Not Applicable

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
2 TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers Terminated NCT02936128 Phase 4
3 Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers Unknown status NCT02130310 Phase 3
4 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
5 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
6 Phase I/II Dose Ranging CHRONSEAL® Study in Venous Leg Ulcers Unknown status NCT00797706 Phase 1, Phase 2 CHRONSEAL
7 EASH Dressing on Chronic Venous Leg Ulcers Completed NCT01497210 Phase 2
8 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
9 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
10 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers Completed NCT00825760 Phase 2 Topical PPA904 gel and light;Topical placebo gel plus light
11 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
12 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers Active, not recruiting NCT02973893 Phase 2
13 Silica Gel Fiber Wound Dressing for Chronic Venous Leg Ulcers Terminated NCT00998673 Phase 2
14 A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers Terminated NCT02154087 Phase 2
15 Cell Therapy for Venous Leg Ulcers Pilot Study Completed NCT01750749 Phase 1
16 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers Completed NCT01754506 Not Applicable
17 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers Completed NCT00628004 Not Applicable
18 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers Completed NCT00627094 Not Applicable
19 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers Completed NCT01671748 Not Applicable
20 Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing Recruiting NCT02024243
21 VLU Non-inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-layer Bandaging Active, not recruiting NCT02680834 Not Applicable
22 Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults Not yet recruiting NCT03576989 Not Applicable
23 Evaluating the Safety and Efficacy of GrafixPL™PRIME for the Treatment of Chronic Venous Leg Ulcers Not yet recruiting NCT03543007 Not Applicable
24 Intermittent Pneumatic Compression of the Foot vs Geko Plus R-2 Neuromuscular Electrostimulation Device in Venous Leg Ulcer Patients Withdrawn NCT02912858 Not Applicable

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf PMIDs: 12055943 12463767 20849380 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

41
Skin, Testes, Neutrophil

Publications for Chronic Venous Leg Ulcers

Articles related to Chronic Venous Leg Ulcers:

(show top 50) (show all 130)
# Title Authors Year
1
Trichloroacetic acid (80%) as a chemical debridement method for chronic venous leg ulcers-A pilot study. ( 29334174 )
2018
2
Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results. ( 29593807 )
2018
3
Reliability and Measurement Error of Digital Planimetry for the Measurement of Chronic Venous Leg Ulcers. ( 28922511 )
2017
4
Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. ( 28834103 )
2017
5
EPAa88+a88DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. ( 28758717 )
2017
6
Comparison of Efficacy of Autologous Platelet-rich Fibrin versus Saline Dressing in Chronic Venous Leg Ulcers: A Randomised Controlled Trial. ( 28529414 )
2017
7
Unna boot central gauze technique for chronic venous leg ulcers. ( 28329467 )
2017
8
Phase 3 Evaluation of HP802-247 in the Treatment of Chronic Venous Leg Ulcers. ( 27495869 )
2016
9
Estimating the Clinical Outcomes and Cost Differences Between Standard Care With and Without Cadexomer Iodine in the Management of Chronic Venous Leg Ulcers Using a Markov Model. ( 27356144 )
2016
10
Healing of Recalcitrant Chronic Venous Leg Ulcers by Punch Grafts Harvested From the Scalp. ( 26262948 )
2015
11
Medical grade honey in the management of chronic venous leg ulcers. ( 26050953 )
2015
12
Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. ( 26408463 )
2015
13
Randomized, controlled study of innovative spray formulation containing ozonated oil and I+-bisabolol in the topical treatment of chronic venous leg ulcers. ( 26280699 )
2015
14
Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100A cm(2)) chronic venous leg ulcers. ( 25595397 )
2015
15
Nutritional profile of older adults with chronic venous leg ulcers: AA pilot study. ( 26141998 )
2015
16
Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. ( 26095122 )
2015
17
Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. ( 24618232 )
2014
18
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343393 )
2014
19
Cost-Effective Use of Silver Dressings for the Treatment of Hard-to-Heal Chronic Venous Leg Ulcers. ( 24945381 )
2014
20
The Effect of a Connexin43-Based Peptide on the Healing of Chronic Venous Leg Ulcers: A Multicenter, Randomized Trial. ( 25072595 )
2014
21
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort. ( 24937814 )
2014
22
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. ( 24839984 )
2014
23
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: a randomised controlled trial. ( 25300315 )
2014
24
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. ( 25498775 )
2014
25
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. ( 24635169 )
2014
26
Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. ( 25492574 )
2014
27
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(Ar) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). ( 24666170 )
2014
28
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343392 )
2014
29
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. ( 25351907 )
2014
30
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. ( 24589044 )
2014
31
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. ( 25382133 )
2014
32
The impact of chronic venous leg ulcers: a systematic review. ( 25492276 )
2014
33
Identification of Symptom Clusters in Patients With Chronic Venous Leg Ulcers. ( 23998779 )
2013
34
Neutrophil activity in chronic venous leg ulcers--a target for therapy? ( 23551462 )
2013
35
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. ( 22833505 )
2013
36
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. ( 23118301 )
2013
37
Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: A 6-month follow-up. ( 23927847 )
2013
38
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. ( 22422794 )
2013
39
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. ( 24072751 )
2013
40
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. ( 23531093 )
2013
41
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. ( 22018697 )
2012
42
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. ( 22150832 )
2012
43
Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. ( 22863328 )
2012
44
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACELAr Ag and UrgotulAr Silver dressing on healing of chronic venous leg ulcers. ( 22066961 )
2012
45
Chronic venous leg ulcers: the future of cell-based therapies. ( 22863327 )
2012
46
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. ( 22074592 )
2012
47
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. ( 22174074 )
2012
48
Insufficient and incomplete shaving in chronic venous leg ulcers leads to a poor prognosis of the skin graft: a histomorphological analysis. ( 21893960 )
2011
49
Duration of wound fluid secretion from chronic venous leg ulcers is critical for interleukin-1I+, interleukin-1I^, interleukin-8 levels and fibroblast activation. ( 21786164 )
2011
50
Increased Lipoprotein (a) concentrations in patients with chronic venous leg ulcers: a study on patients with or without postthrombotic syndrome. ( 21362083 )
2011

Variations for Chronic Venous Leg Ulcers

Expression for Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for Chronic Venous Leg Ulcers

Pathways related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.44 FASLG ITGA4 LTA MMP9 MYC TIMP1
2
Show member pathways
13.41 FASLG ITGA4 LTA MYC TIMP1
3
Show member pathways
13.21 FASLG ITGA4 LTA MMP9 MYC TIMP1
4
Show member pathways
13.13 ITGA4 LTA MYC TIMP1
5
Show member pathways
13.01 FASLG ITGA4 LTA TIMP1
6
Show member pathways
12.66 FASLG LTA MMP9 MYC TIMP1
7 12.51 FASLG MMP9 MYC
8
Show member pathways
12.48 FASLG LTA MYC
9
Show member pathways
12.37 ITGA4 MMP9 TIMP1
10
Show member pathways
12.15 FASLG MMP9 MYC
11 11.8 FASLG MMP9 MYC
12
Show member pathways
11.62 MMP9 TIMP1
13 11.57 MMP9 TIMP1
14
Show member pathways
11.55 MYC TIMP1
15 11.51 MMP9 MYC
16 11.49 ITGA4 LTA
17 11.47 MMP9 MYC
18 11.42 MMP9 MYC
19 11.32 MMP9 TIMP1
20 11.3 MMP9 TIMP1
21 11.2 FASLG MYC
22 11.12 FASLG ITGA4
23 10.98 FASLG MMP9 MYC TIMP1
24
Show member pathways
10.96 FASLG LTA MYC
25 10.91 FASLG LTA
26 10.8 MMP9 TIMP1

GO Terms for Chronic Venous Leg Ulcers

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.7 MMP9 MYC TIMP1
2 positive regulation of cell proliferation GO:0008284 9.69 FASLG MYC TIMP1
3 regulation of signaling receptor activity GO:0010469 9.65 FASLG LTA TIMP1
4 positive regulation of apoptotic process GO:0043065 9.63 FASLG LTA MMP9
5 extracellular matrix disassembly GO:0022617 9.49 MMP9 TIMP1
6 negative regulation of fibroblast proliferation GO:0048147 9.43 LTA MYC
7 endodermal cell differentiation GO:0035987 9.4 ITGA4 MMP9
8 positive regulation of DNA binding GO:0043388 9.37 MMP9 MYC
9 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.32 FASLG MMP9
10 positive regulation of endothelial cell apoptotic process GO:2000353 9.26 FASLG ITGA4
11 response to growth factor GO:0070848 9.16 FASLG MYC
12 positive regulation of glial cell proliferation GO:0060252 8.96 LTA MYC
13 cytokine-mediated signaling pathway GO:0019221 8.92 FASLG MMP9 MYC TIMP1

Molecular functions related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 FASLG LTA
2 cytokine activity GO:0005125 8.8 FASLG LTA TIMP1

Sources for Chronic Venous Leg Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....