MCID: CHR415
MIFTS: 36

Chronic Venous Leg Ulcers

Aliases & Classifications for Chronic Venous Leg Ulcers

MalaCards integrated aliases for Chronic Venous Leg Ulcers:

Name: Chronic Venous Leg Ulcers 39 56

Summaries for Chronic Venous Leg Ulcers

MalaCards based summary : Chronic Venous Leg Ulcers is related to chronic venous insufficiency and venous insufficiency. An important gene associated with Chronic Venous Leg Ulcers is TIMP1 (TIMP Metallopeptidase Inhibitor 1), and among its related pathways/superpathways are Pathways in cancer and Matrix Metalloproteinases. The drugs Carboxymethylcellulose Sodium and Laxatives have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and neutrophil, and related phenotypes are neoplasm and respiratory system

Related Diseases for Chronic Venous Leg Ulcers

Diseases related to Chronic Venous Leg Ulcers via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 chronic venous insufficiency 30.4 MMP9 TIMP1
2 venous insufficiency 30.4 MMP9 TIMP1
3 autoimmune inner ear disease 10.2 MMP9 TIMP1
4 inner ear disease 10.2 MMP9 TIMP1
5 fungal keratitis 10.2 MMP9 TIMP1
6 cryptogenic organizing pneumonia 10.2 MMP9 TIMP1
7 conjunctival nevus 10.2 MMP9 TIMP1
8 nasal cavity squamous cell carcinoma 10.2 MMP9 TIMP1
9 aortic aneurysm, familial abdominal, 1 10.2 MMP9 TIMP1
10 appendicitis 10.2 MMP9 TIMP1
11 bronchiolitis obliterans 10.1 MMP9 TIMP1
12 pulmonary emphysema 10.1 MMP9 TIMP1
13 carotid artery disease 10.1 MMP9 TIMP1
14 varicose veins 10.1 MMP9 TIMP1
15 inguinal hernia 10.1 MMP9 TIMP1
16 epithelial basement membrane dystrophy 10.1 FAS MMP9
17 thrombophilia 10.1
18 relapsing-remitting multiple sclerosis 10.1 MMP9 TIMP1
19 photokeratitis 10.1 FASLG MMP9
20 type ii mixed cryoglobulinemia 10.0 FAS FASLG
21 lymphocytic gastritis 10.0 FAS FASLG
22 periodontitis 10.0 MMP9 TIMP1
23 lymphomatoid papulosis 10.0 FAS FASLG
24 cartilage-hair hypoplasia 10.0 FAS FASLG
25 acute myocarditis 10.0 FAS FASLG
26 kawasaki disease 10.0 MMP9 TIMP1
27 epstein-barr virus-associated gastric carcinoma 10.0 FAS FASLG
28 microvascular complications of diabetes 1 10.0 MMP9 TIMP1
29 silicosis 10.0 FAS FASLG
30 severe cutaneous adverse reaction 10.0 FAS FASLG
31 pneumoconiosis 10.0 FAS FASLG
32 lymphopenia 9.9 FAS FASLG
33 thrombophilia due to activated protein c resistance 9.9
34 hemochromatosis, type 1 9.9
35 bornholm eye disease 9.9
36 dermatitis, atopic 9.9
37 reflex sympathetic dystrophy 9.9
38 algoneurodystrophy 9.9
39 post-thrombotic syndrome 9.9
40 dermatitis 9.9
41 pyoderma 9.9
42 pyoderma gangrenosum 9.9
43 juvenile hereditary hemochromatosis 9.9
44 rapidly involuting congenital hemangioma 9.9
45 graft-versus-host disease 9.9 FAS FASLG
46 west nile fever 9.9 DEFA1 DEFA3
47 mite infestation 9.9 DEFA1 DEFA3
48 viral hepatitis 9.9 FAS FASLG
49 bell's palsy 9.9 DEFA1 DEFA3
50 lymphoproliferative syndrome 9.9 FAS FASLG

Graphical network of the top 20 diseases related to Chronic Venous Leg Ulcers:



Diseases related to Chronic Venous Leg Ulcers

Symptoms & Phenotypes for Chronic Venous Leg Ulcers

MGI Mouse Phenotypes related to Chronic Venous Leg Ulcers:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 FAS FASLG MMP9 TIMP1
2 respiratory system MP:0005388 8.92 FAS FASLG MMP9 TIMP1

Drugs & Therapeutics for Chronic Venous Leg Ulcers

Drugs for Chronic Venous Leg Ulcers (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Carboxymethylcellulose Sodium Phase 4
2 Laxatives Phase 4
3 Cathartics Phase 4
4 Gastrointestinal Agents Phase 4
5
Thrombin Approved, Investigational Phase 3
6 Hemostatics Phase 3
7 Pharmaceutical Solutions Phase 3
8 Coagulants Phase 3
9
Mecasermin Approved, Investigational Phase 2 68562-41-4
10 Mitogens Phase 1, Phase 2,Phase 2
11 Anti-Bacterial Agents Phase 2
12 Anti-Infective Agents Phase 2
13 Somatomedin B Phase 2
14 insulin Phase 2
15 Insulin, Globin Zinc Phase 2
16
Mineral oil Approved, Vet_approved Not Applicable 8042-47-5
17
Ibuprofen Approved Not Applicable 15687-27-1 3672
18
Monensin Experimental, Vet_approved Not Applicable 17090-79-8
19 Omega 3 Fatty Acid Not Applicable
20 Dermatologic Agents Not Applicable
21 Emollients Not Applicable

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 AQUACEL® Ag Dressing and Urgotul® Silver Dressing on Healing of Chronic Venous Leg Ulcers Completed NCT01084577 Phase 4
2 TruSkin®: Study for Treatment of Chronic Venous Leg Ulcers Terminated NCT02936128 Phase 4
3 Evaluation of CureXcell® in Treating Chronic Venous Leg Ulcers Unknown status NCT02130310 Phase 3
4 Chronic Venous ULcer TReatment Analyzing Bio-Electrical Stimulation Therapy Unknown status NCT00678847 Phase 2, Phase 3
5 Safety and Efficacy Trial of HP802-247 in the Treatment of Chronic Venous Leg Ulcers Terminated NCT01853384 Phase 3
6 Phase I/II Dose Ranging CHRONSEAL® Study in Venous Leg Ulcers Unknown status NCT00797706 Phase 1, Phase 2 CHRONSEAL
7 EASH Dressing on Chronic Venous Leg Ulcers Completed NCT01497210 Phase 2
8 Surface NeuroMuscular Electrical Stimulation in the Treatment of Chronic Venous Leg Ulcers Completed NCT01801891 Phase 2
9 The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study Completed NCT01770509 Phase 1, Phase 2
10 Clinical Trial to Investigate Treatment With Photodynamic Therapy to Reduce Levels of Bacteria in Leg Ulcers Completed NCT00825760 Phase 2 Topical PPA904 gel and light;Topical placebo gel plus light
11 Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers Recruiting NCT02742844 Phase 1, Phase 2
12 Study of VF001-DP in Patients With Chronic Venous Leg Ulcers Active, not recruiting NCT02973893 Phase 2
13 Silica Gel Fiber Wound Dressing for Chronic Venous Leg Ulcers Terminated NCT00998673 Phase 2
14 A Phase 2 Exploratory Pharmacodynamic Study of HP802-247 in Venous Leg Ulcers Terminated NCT02154087 Phase 2
15 Cell Therapy for Venous Leg Ulcers Pilot Study Completed NCT01750749 Phase 1
16 Testing Fish Oil Derivatives In Healing Of Chronic Venous Leg Ulcers Completed NCT01754506 Not Applicable
17 Safety Evaluation of Biatain Ibu in Painful Chronic Venous Leg Ulcers Completed NCT00628004 Not Applicable
18 Biatain Ibu vs. Biatain in Painful Chronic Venous Leg Ulcers Completed NCT00627094 Not Applicable
19 MIST Ultrasound Therapy Compared to United Kingdom Standard Care for the Treatment of Non-healing Venous Leg Ulcers Completed NCT01671748 Not Applicable
20 Impact of Omega-3 Fatty Acid Oral Therapy on Healing of Chronic Venous Leg Ulcers in Older Adults Recruiting NCT03576989 Not Applicable
21 Clinical Effectiveness of DermACELL AWM in Subjects With Chronic Venous Leg Ulcers Recruiting NCT03589586 Not Applicable
22 Randomized Controlled Trial for Treatment of Pain and Assessment of Wound Healing in Chronic Venous Leg Ulcers Using Near Infrared Laser Therapy Recruiting NCT03716167 Not Applicable
23 Study to Evaluate Safety and Efficacy of GrafixPL for the Treatment of Venous Leg Ulcers Recruiting NCT03629236 Not Applicable
24 Role of Tissue Oxygenation and the miR-210 Gene In Wound Healing Recruiting NCT02024243
25 VLU Non-inferiority Study Comparing a Dual Action Pneumatic Compression Device to Multi-layer Bandaging Active, not recruiting NCT02680834 Not Applicable
26 Standard Compression Therapy With/Without Application of Skin Allograft (Theraskin) for Venous Leg Ulcer Treatment Enrolling by invitation NCT03935386 Not Applicable
27 Intermittent Pneumatic Compression of the Foot vs Geko Plus R-2 Neuromuscular Electrostimulation Device in Venous Leg Ulcer Patients Withdrawn NCT02912858 Not Applicable

Search NIH Clinical Center for Chronic Venous Leg Ulcers

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Chronic Venous Leg Ulcers cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Chronic Venous Leg Ulcers:
Apligraf, skin substitute for chronic venous leg ulcers and diabetic foot ulcers
Embryonic/Adult Cultured Cells Related to Chronic Venous Leg Ulcers:
Bilayered bioengineered skin substitute (Apligraf�) PMIDs: 12055943 12463767 20849380 18615798

Genetic Tests for Chronic Venous Leg Ulcers

Anatomical Context for Chronic Venous Leg Ulcers

MalaCards organs/tissues related to Chronic Venous Leg Ulcers:

42
Skin, Testes, Neutrophil, Lung, Eye

Publications for Chronic Venous Leg Ulcers

Articles related to Chronic Venous Leg Ulcers:

(show top 50) (show all 130)
# Title Authors Year
1
Development and validation of a gene expression test to identify hard-to-heal chronic venous leg ulcers. ( 31095725 )
2019
2
Autologous platelet-rich plasma for healing chronic venous leg ulcers: Clinical efficacy and potential mechanisms. ( 30864220 )
2019
3
Prospective study of cryopreserved placental tissue wound matrix in the management of chronic venous leg ulcers. ( 30621916 )
2019
4
The effectiveness of hyperbaric oxygen therapy for healing chronic venous leg ulcers: A randomized, double-blind, placebo-controlled trial. ( 30129080 )
2018
5
Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results. ( 29593807 )
2018
6
Trichloroacetic acid (80%) as a chemical debridement method for chronic venous leg ulcers-A pilot study. ( 29334174 )
2018
7
Autologous platelet-rich plasma versus conventional therapy for the treatment of chronic venous leg ulcers: A comparative study. ( 28834103 )
2018
8
Unna boot central gauze technique for chronic venous leg ulcers. ( 28329467 )
2017
9
EPA + DHA supplementation reduces PMN activation in microenvironment of chronic venous leg ulcers: A randomized, double-blind, controlled study. ( 28758717 )
2017
10
Reliability and measurement error of digital planimetry for the measurement of chronic venous leg ulcers. ( 28922511 )
2017
11
Comparison of Efficacy of Autologous Platelet-rich Fibrin versus Saline Dressing in Chronic Venous Leg Ulcers: A Randomised Controlled Trial. ( 28529414 )
2017
12
Efficacy and cost-effectiveness of octenidine wound gel in the treatment of chronic venous leg ulcers in comparison to modern wound dressings. ( 24589044 )
2016
13
Extracellular matrix assessment of infected chronic venous leg ulcers: role of metalloproteinases and inflammatory cytokines. ( 24618232 )
2016
14
Chronic venous leg ulcers: Effects of foam sclerotherapy on healing and recurrence. ( 25351907 )
2016
15
Safety and performance evaluation of a next-generation antimicrobial dressing in patients with chronic venous leg ulcers. ( 26095122 )
2016
16
Estimating the Clinical Outcomes and Cost Differences Between Standard Care With and Without Cadexomer Iodine in the Management of Chronic Venous Leg Ulcers Using a Markov Model. ( 27356144 )
2016
17
Phase 3 evaluation of HP802-247 in the treatment of chronic venous leg ulcers. ( 27495869 )
2016
18
Alleviation of chronic venous leg ulcers with a hand-held dielectric barrier discharge plasma generator (PlasmaDerm(®) VU-2010): results of a monocentric, two-armed, open, prospective, randomized and controlled trial (NCT01415622). ( 24666170 )
2015
19
The effect of a connexin43-based Peptide on the healing of chronic venous leg ulcers: a multicenter, randomized trial. ( 25072595 )
2015
20
Maggots as a wound debridement agent for chronic venous leg ulcers under graduated compression bandages: A randomised controlled trial. ( 25300315 )
2015
21
Autologous platelet-rich plasma in treatment of chronic venous leg ulcers: A prospective case series. ( 25492574 )
2015
22
Cost analysis of negative-pressure wound therapy with instillation for wound bed preparation preceding split-thickness skin grafts for massive (>100 cm(2)) chronic venous leg ulcers. ( 25595397 )
2015
23
Medical grade honey in the management of chronic venous leg ulcers. ( 26050953 )
2015
24
Nutritional profile of older adults with chronic venous leg ulcers: a pilot study. ( 26141998 )
2015
25
Healing of Recalcitrant Chronic Venous Leg Ulcers by Punch Grafts Harvested From the Scalp. ( 26262948 )
2015
26
Randomized, controlled study of innovative spray formulation containing ozonated oil and α-bisabolol in the topical treatment of chronic venous leg ulcers. ( 26280699 )
2015
27
Squamous cell carcinomas in chronic venous leg ulcers. Data of the German Marjolin Registry and review. ( 26408463 )
2015
28
Identification of symptom clusters in patients with chronic venous leg ulcers. ( 23998779 )
2014
29
Catheter-directed foam sclerotherapy for chronic venous leg ulcers. ( 24072751 )
2014
30
Chronic venous leg ulcers: is topical zinc the answer? A review of the literature. ( 24343392 )
2014
31
Comparative effectiveness of advanced wound dressings for patients with chronic venous leg ulcers: a systematic review. ( 24635169 )
2014
32
Randomized standard-of-care-controlled trial of a silica gel fibre matrix in the treatment of chronic venous leg ulcers. ( 24839984 )
2014
33
Factors that influence healing of chronic venous leg ulcers: a retrospective cohort. ( 24937814 )
2014
34
Cost-effective use of silver dressings for the treatment of hard-to-heal chronic venous leg ulcers. ( 24945381 )
2014
35
A topical haemoglobin spray for oxygenating chronic venous leg ulcers: a pilot study. ( 25382133 )
2014
36
The impact of chronic venous leg ulcers: a systematic review. ( 25492276 )
2014
37
Cost-effectiveness of three adjunct cellular/tissue-derived products used in the management of chronic venous leg ulcers. ( 25498775 )
2014
38
Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. ( 22422794 )
2013
39
Healing rates following venous surgery for chronic venous leg ulcers in an independent specialist vein unit. ( 22833505 )
2013
40
Proteolytic activity by multiple bacterial species isolated from chronic venous leg ulcers degrades matrix substrates. ( 23118301 )
2013
41
Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. ( 23531093 )
2013
42
Neutrophil activity in chronic venous leg ulcers--a target for therapy? ( 23551462 )
2013
43
Durability of healing from spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a 6-month follow-up. ( 23927847 )
2013
44
Skin grafting followed by low-molecular-weight heparin long-term therapy in chronic venous leg ulcers. ( 22018697 )
2012
45
A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACEL® Ag and Urgotul® Silver dressing on healing of chronic venous leg ulcers. ( 22066961 )
2012
46
Effectiveness and tissue compatibility of a 12-week treatment of chronic venous leg ulcers with an octenidine based antiseptic--a randomized, double-blind controlled study. ( 22074592 )
2012
47
Healing of chronic venous leg ulcers could be affected by an interaction of the hemochromatosis gene polymorphism HFE H63D with the strength of compression treatment--a re-analysis of patients from previous studies. ( 22150832 )
2012
48
Exploratory study on the effectiveness of a standardized extract from Ageratina pichinchensis in patients with chronic venous leg ulcers. ( 22174074 )
2012
49
Chronic venous leg ulcers: the future of cell-based therapies. ( 22863327 )
2012
50
Spray-applied cell therapy with human allogeneic fibroblasts and keratinocytes for the treatment of chronic venous leg ulcers: a phase 2, multicentre, double-blind, randomised, placebo-controlled trial. ( 22863328 )
2012

Variations for Chronic Venous Leg Ulcers

Expression for Chronic Venous Leg Ulcers

Search GEO for disease gene expression data for Chronic Venous Leg Ulcers.

Pathways for Chronic Venous Leg Ulcers

GO Terms for Chronic Venous Leg Ulcers

Cellular components related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 DEFA1 DEFA3 FASLG MMP9 TIMP1
2 extracellular region GO:0005576 9.43 DEFA1 DEFA3 FAS FASLG MMP9 TIMP1
3 Golgi lumen GO:0005796 9.32 DEFA1 DEFA3
4 azurophil granule lumen GO:0035578 9.26 DEFA1 DEFA3
5 extracellular exosome GO:0070062 9.1 DEFA1 DEFA3 FAS FASLG MMP9 TIMP1

Biological processes related to Chronic Venous Leg Ulcers according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 FAS MMP9 TIMP1
2 immune response GO:0006955 9.75 DEFA1 FAS FASLG
3 positive regulation of apoptotic process GO:0043065 9.7 FAS FASLG MMP9
4 cytokine-mediated signaling pathway GO:0019221 9.63 FASLG MMP9 TIMP1
5 defense response to Gram-positive bacterium GO:0050830 9.6 DEFA1 DEFA3
6 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.59 FAS FASLG
7 defense response to Gram-negative bacterium GO:0050829 9.58 DEFA1 DEFA3
8 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.57 DEFA1 DEFA3
9 apoptotic signaling pathway GO:0097190 9.56 FAS FASLG
10 extracellular matrix disassembly GO:0022617 9.55 MMP9 TIMP1
11 antimicrobial humoral response GO:0019730 9.54 DEFA1 DEFA3
12 extrinsic apoptotic signaling pathway GO:0097191 9.51 FAS FASLG
13 killing of cells of other organism GO:0031640 9.49 DEFA1 DEFA3
14 antibacterial humoral response GO:0019731 9.48 DEFA1 DEFA3
15 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FAS FASLG
16 defense response to fungus GO:0050832 9.4 DEFA1 DEFA3
17 innate immune response in mucosa GO:0002227 9.37 DEFA1 DEFA3
18 intracellular estrogen receptor signaling pathway GO:0030520 9.32 DEFA1 DEFA3
19 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.26 FASLG MMP9
20 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.16 FAS FASLG
21 membrane disruption in other organism GO:0051673 8.96 DEFA1 DEFA3
22 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Chronic Venous Leg Ulcers

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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