Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 44 D034081
UMLS 73 C1135993

Summaries for Chronic Wasting Disease

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to kuru and scrapie, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Complement and coagulation cascades and Immune response Lectin induced complement pathway. The drugs Caseins and Soy Bean have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and tonsil.

Wikipedia : 76 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of mule deer,... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 kuru 31.0 ERC1 PRNP
2 scrapie 31.0 PRNP SPRN
3 prion disease 30.4 CR2 PRNP SPRN
4 creutzfeldt-jakob disease 28.6 PRNP SPRN
5 genetic prion diseases 11.1
6 encephalopathy 10.2
7 mucositis 10.0
8 aging 9.9
9 tonsillitis 9.8
10 lymphocytic choriomeningitis 9.7
11 lupus erythematosus 9.4 C1QC CR2

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins Not Applicable
2 Soy Bean Nutraceutical Not Applicable
3 Whey Protein Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Active, not recruiting NCT02072057 Phase 2 Ruxolitinib
2 Disturbances in BCAA Metabolism and the Effects of Feeding and Exercise in COPD Completed NCT01418469 Not Applicable
3 Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer Active, not recruiting NCT03061370

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

41
Brain, Testes, Tonsil, Lymph Node, Skeletal Muscle, B Cells, Retina

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 277)
# Title Authors Year
1
Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling. ( 29118163 )
2018
2
Pathologic and biochemical characterization of PrP<sup>Sc</sup> from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent. ( 29523205 )
2018
3
Chronic wasting disease management in ranched elk using rectal biopsy testing. ( 29424295 )
2018
4
CATTLE ( BOS TAURUS) RESIST CHRONIC WASTING DISEASE FOLLOWING ORAL INOCULATION CHALLENGE OR TEN YEARS' NATURAL EXPOSURE IN CONTAMINATED ENVIRONMENTS. ( 29715064 )
2018
5
Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques. ( 29695429 )
2018
6
Chronic wasting disease: an evolving prion disease of cervids. ( 29887133 )
2018
7
Mineral licks as environmental reservoirs of chronic wasting disease prions. ( 29719000 )
2018
8
Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids. ( 29580373 )
2018
9
EVALUATION OF A TEST AND CULL STRATEGY FOR REDUCING PREVALENCE OF CHRONIC WASTING DISEASE IN MULE DEER ( ODOCOILEUS HEMIONUS). ( 29667874 )
2018
10
Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids. ( 28783058 )
2017
11
Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion. ( 28703697 )
2017
12
Molecular Mechanisms of Chronic Wasting Disease Prion Propagation. ( 28193766 )
2017
13
Pathways of Prion Spread during Early Chronic Wasting Disease in Deer. ( 28250130 )
2017
14
Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion. ( 29058651 )
2017
15
Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation. ( 28701407 )
2017
16
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review. ( 28139079 )
2017
17
High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population. ( 28350512 )
2017
18
Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study. ( 29098931 )
2017
19
Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. ( 29105545 )
2017
20
Detection of Prions in Blood of Cervids at the Asymptomatic Stage of Chronic Wasting Disease. ( 29222449 )
2017
21
Clay content and pH: soil characteristic associations with the persistent presence of chronic wasting disease in northern Illinois. ( 29273783 )
2017
22
Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro. ( 28874781 )
2017
23
Chronic wasting disease: Emerging prions and their potential risk. ( 29095921 )
2017
24
Temporal patterns of chronic wasting disease prion excretion in three cervid species. ( 28708047 )
2017
25
Chronic wasting disease prion infection of differentiated neurospheres. ( 28762865 )
2017
26
Contact tracing for the control of infectious disease epidemics: Chronic Wasting Disease in deer farms. ( 29329958 )
2017
27
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion. ( 28820384 )
2017
28
Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer. ( 28539446 )
2017
29
Endemic chronic wasting disease causes mule deer population decline in Wyoming. ( 29049389 )
2017
30
Induction of PrP<sup>Sc</sup>-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease. ( 28968152 )
2017
31
Pathogen-mediated selection in free-ranging elk populations infected by chronic wasting disease. ( 29087314 )
2017
32
EFSA proposes surveillance scheme for chronic wasting disease. ( 28154211 )
2017
33
Horizontal Transmission of Chronic Wasting Disease in Reindeer. ( 27869594 )
2016
34
Chronic wasting disease of deer - is the battle to keep Europe free already lost? ( 27474059 )
2016
35
Seeded Amplification of Chronic Wasting Disease Prions in Nasal Brushings and Recto-anal Mucosa-Associated Lymphoid Tissues from Elk by Real-Time Quaking-Induced Conversion. ( 26888899 )
2016
36
Chronic wasting disease in white-tailed deer: infection, mortality, and implications for heterogeneous transmission. ( 27870037 )
2016
37
Applications of mathematical modeling in managing the spread of chronic wasting disease (CWD) in wild deer under alternative harvesting scenarios. ( 27556563 )
2016
38
Intra-host mathematical model of chronic wasting disease dynamics in deer (Odocoileus). ( 27537196 )
2016
39
Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. ( 27031704 )
2016
40
First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer. ( 27641251 )
2016
41
Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion. ( 26865693 )
2016
42
Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. ( 27575545 )
2016
43
Systematic review of management strategies to control chronic wasting disease in wild deer populations in North America. ( 27549119 )
2016
44
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment. ( 27711208 )
2016
45
Using expert judgments to improve chronic wasting disease risk management in Canada. ( 27556565 )
2016
46
Expert elicitation on the uncertainties associated with chronic wasting disease. ( 27556566 )
2016
47
Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion. ( 27829062 )
2016
48
Chronic Wasting Disease: Transmission Mechanisms and the Possibility of Harvest Management. ( 26963921 )
2016
49
Dietary Magnesium and Copper Affect Survival Time and Neuroinflammation in Chronic Wasting Disease. ( 27216881 )
2016
50
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine or cervid prion protein. ( 27393736 )
2016

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 8.62 PRNP SPRN

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 8.96 C1QC CR2
2 regulation of complement activation GO:0030449 8.62 C1QC CR2

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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