MCID: CHR028
MIFTS: 30

Chronic Wasting Disease

Categories: Neuronal diseases

Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 44 72

Classifications:



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Disease Ontology 12 DOID:3530
MeSH 44 D034081
UMLS 72 C1135993

Summaries for Chronic Wasting Disease

CDC : 3 Chronic wasting disease (CWD) is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, including Canada and the United States, Norway and South Korea. It may take over a year before an infected animal develops symptoms, which can include drastic weight loss (wasting), stumbling, listlessness and other neurologic symptoms. CWD can affect animals of all ages and some infected animals may die without ever developing the disease. CWD is fatal to animals and there are no treatments or vaccines. To date, there have been no reported cases of CWD infection in people. However, some animal studies suggest CWD poses a risk to certain types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain.

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to kuru and prion disease, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein). The drugs Caseins and Soy Bean have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related phenotype is mortality/aging.

Wikipedia : 75 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting cervids, the... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 kuru 31.6 PRNP ERC1
2 prion disease 30.8 SPRN RPSA PRNP CR2
3 scrapie 29.9 SPRN RPSA PRNP
4 creutzfeldt-jakob disease 29.5 SPRN RPSA PRNP
5 encephalopathy 10.7
6 genetic prion diseases 10.4
7 bruxism 9.9
8 alzheimer disease 9.8
9 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
10 ataxia and polyneuropathy, adult-onset 9.8
11 endometrial hyperplasia 9.8
12 endometritis 9.8
13 mastitis 9.8
14 myiasis 9.8
15 rabies 9.8
16 lymphocytic choriomeningitis 9.8
17 gastroenteritis 9.8
18 neuroaxonal dystrophy 9.8
19 amyloidosis 9.8
20 47,xyy 9.8
21 tremor 9.8

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

MGI Mouse Phenotypes related to Chronic Wasting Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 CR2 ERC1 PIP5K1C PRNP RPSA SPRN

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins
2 Soy Bean
3 Whey Protein

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Terminated NCT02072057 Phase 2 Ruxolitinib
2 The Effects of Exercise on the Metabolic Fate of Branched Chain Amino Acids in Relation to Aging and Chronic Disease. Completed NCT01418469

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

41
Brain, Testes, Lymph Node, T Cells, Skeletal Muscle, B Cells, Tonsil

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 628)
# Title Authors PMID Year
1
Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier. 38
30592012 2019
2
Gene-edited murine cell lines for propagation of chronic wasting disease prions. 38
31371793 2019
3
Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species. 38
31337719 2019
4
Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe. 38
31366372 2019
5
Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice. 38
31147460 2019
6
Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages. 38
30831227 2019
7
An autopsy case of peliosis hepatis with X-linked myotubular myopathy. 38
31030121 2019
8
Estimating the amount of Chronic Wasting Disease infectivity passing through abattoirs and field slaughter. 38
30935503 2019
9
BSE infectivity survives burial for five years with only limited spread. 38
30799509 2019
10
Raccoons accumulate PrPSc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie. 38
30694116 2019
11
First Detection of Chronic Wasting Disease in a Wild Red Deer ( Cervus elaphus) in Europe. 38
30920905 2019
12
Animal prion diseases: the risks to human health. 38
30588682 2019
13
Development of an antigen ELISA using monoclonal antibodies against recombinant VSG for the detection of active infections of Trypanosoma evansi in animals. 38
30736948 2019
14
Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer. 38
30717795 2019
15
Rapid recontamination of a farm building occurs after attempted prion removal. 38
30602491 2019
16
Sodium hydroxide treatment effectively inhibits PrPCWD replication in farm soil. 38
31258051 2019
17
Use of faecal volatile organic compound analysis for ante-mortem discrimination between CWD-positive, -negative exposed, and -known negative white-tailed deer (Odocoileus virginianus). 38
31032718 2019
18
Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay. 38
30670087 2019
19
Cellular and Molecular Mechanisms of Prion Disease. 38
30355150 2019
20
RECENT CHANGES IN INFECTIOUS DISEASES IN EUROPEAN WILDLIFE. 38
30284963 2019
21
Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool. 38
31071138 2019
22
Spatial heterogeneity of prion gene polymorphisms in an area recently infected by chronic wasting disease. 38
30777498 2019
23
Assessment of humaneness using gunshot targeting the brain and cervical spine for cervid depopulation under field conditions. 38
30818392 2019
24
Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway. 38
30457526 2018
25
Recombinant prion protein vaccination of transgenic elk PrP mice and reindeer overcomes self-tolerance and protects mice against chronic wasting disease. 38
30397182 2018
26
Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment. 38
30414779 2018
27
Soil humic acids degrade CWD prions and reduce infectivity. 38
30496301 2018
28
Interspecies transmission to bovinized transgenic mice uncovers new features of a CH1641-like scrapie isolate. 38
30486902 2018
29
Heterogeneity of a landscape influences size of home range in a North American cervid. 38
30279590 2018
30
Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions. 38
29950332 2018
31
A reindeer cull to prevent chronic wasting disease in Europe. 38
29988166 2018
32
A Bioluminescent Cell Assay to Quantify Prion Protein Dimerization. 38
30242186 2018
33
Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions. 38
30014840 2018
34
Evidence of Powassan/deer tick virus in adult black-legged ticks (Ixodes scapularis) recovered from hunter-harvested white-tailed deer (Odocoileus virginianus) in Pennsylvania: A public health perspective. 38
29707917 2018
35
A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFN╬│ to generate self-tolerance and prevent colitis. 38
29728642 2018
36
CATTLE ( BOS TAURUS) RESIST CHRONIC WASTING DISEASE FOLLOWING ORAL INOCULATION CHALLENGE OR TEN YEARS' NATURAL EXPOSURE IN CONTAMINATED ENVIRONMENTS. 38
29715064 2018
37
EVALUATION OF A TEST AND CULL STRATEGY FOR REDUCING PREVALENCE OF CHRONIC WASTING DISEASE IN MULE DEER ( ODOCOILEUS HEMIONUS). 38
29667874 2018
38
Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques. 38
29695429 2018
39
Contact tracing for the control of infectious disease epidemics: Chronic Wasting Disease in deer farms. 38
29329958 2018
40
Molecular Mechanisms of Chronic Wasting Disease Prion Propagation. 38
28193766 2018
41
Winter feeding of elk in the Greater Yellowstone Ecosystem and its effects on disease dynamics. 38
29531148 2018
42
Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids. 38
29580373 2018
43
Monomorphic pathogens: The case of Candidatus Xenohaliotis californiensis from abalone in California, USA and Baja California, Mexico. 38
29577877 2018
44
Dehydration of Prions on Environmentally Relevant Surfaces Protects Them from Inactivation by Freezing and Thawing. 38
29386284 2018
45
Low sequence diversity of the prion protein gene (PRNP) in wild deer and goat species from Spain. 38
29631620 2018
46
Deterministic and stochastic analysis of an eco-epidemiological model. 38
28988403 2018
47
Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent. 38
29523205 2018
48
Chronic wasting disease management in ranched elk using rectal biopsy testing. 38
29424295 2018
49
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review. 38
28139079 2018
50
The Structure of PrPSc Prions. 38
29414853 2018

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.17 UQCC2 SPRN RPSA PRNP PIP5K1C ERC1
2 anchored component of membrane GO:0031225 8.96 SPRN PRNP

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 8.65 PIP5K1C
2 viral entry into host cell GO:0046718 8.62 RPSA CR2

Molecular functions related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 8.62 RPSA CR2

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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