MCID: CHR028
MIFTS: 34

Chronic Wasting Disease

Categories: Neuronal diseases

Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 43 D034081
UMLS 71 C1135993

Summaries for Chronic Wasting Disease

CDC : 3 Chronic wasting disease (CWD) is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, including Canada and the United States, Norway and South Korea. It may take over a year before an infected animal develops symptoms, which can include drastic weight loss (wasting), stumbling, listlessness and other neurologic symptoms. CWD can affect animals of all ages and some infected animals may die without ever developing the disease. CWD is fatal to animals and there are no treatments or vaccines. To date, there have been no reported cases of CWD infection in people. However, some animal studies suggest CWD poses a risk to certain types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain.

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to kuru and prion disease, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Whey Protein and Caseins have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node.

Wikipedia : 74 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting cervids, the... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 kuru 31.0 SPRN SCN2A PRNP PRND PRDM10 MSMB
2 prion disease 29.6 SPRN SOD1 SCN2A RPSA PRNP PRND
3 scrapie 29.4 SPRN SCN2A RPSA PRNP PRND PRDM10
4 creutzfeldt-jakob disease 29.4 SPRN RPSA PRNP PRND PRDM10 MSMB
5 encephalopathy 10.7
6 genetic prion diseases 10.4
7 cerebellopontine angle primitive neuroectodermal 10.3 GFAP CR2
8 endobronchial leiomyoma 10.2 GFAP CR2
9 binswanger's disease 10.1 GFAP APP
10 leukoencephalopathy, hereditary diffuse, with spheroids 10.0 PRNP GFAP APP
11 cerebral degeneration 10.0 PRDM10 GFAP APP
12 bruxism 9.9
13 cerebral amyloid angiopathy, itm2b-related, 1 9.8 PRNP APP
14 pervasive developmental disorder 9.8 SCN2A PRDM10 GFAP APP
15 mitochondrial dna depletion syndrome 11 9.8 UQCC2 SSBP1
16 alzheimer disease 9.8
17 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
18 ataxia and polyneuropathy, adult-onset 9.8
19 helix syndrome 9.8
20 endometrial hyperplasia 9.8
21 endometritis 9.8
22 mastitis 9.8
23 myiasis 9.8
24 rabies 9.8
25 lymphocytic choriomeningitis 9.8
26 gastroenteritis 9.8
27 neuroaxonal dystrophy 9.8
28 amyloidosis 9.8
29 tremor 9.8
30 gerstmann-straussler disease 9.6 SPRN SCN2A PRNP PRND MSMB APP
31 supranuclear palsy, progressive, 1 9.6 SOD1 PRNP APP
32 wilson disease 9.6 SOD1 PRNP APP
33 vascular dementia 9.6 SOD1 PRNP APP
34 spastic paraplegia 38, autosomal dominant 9.5 SOD1 GFAP
35 dementia 9.4 SOD1 PRNP GFAP APP
36 central nervous system disease 9.4 SOD1 PRNP GFAP APP
37 peripheral nervous system disease 9.4 SOD1 PRDM10 GFAP APP
38 frontotemporal dementia 9.3 SOD1 PRNP GFAP APP
39 toxic encephalopathy 9.3 SOD1 PRNP PRDM10 GFAP APP
40 dementia, lewy body 9.2 SOD1 PRNP PRDM10 GFAP APP
41 pick disease of brain 9.2 SOD1 PRNP PRDM10 GFAP APP
42 aceruloplasminemia 9.2 SOD1 PRNP PRDM10 GFAP APP
43 fatal familial insomnia 9.2 SPRN PRNP PRND PRDM10 MSMB GFAP
44 amyotrophic lateral sclerosis 1 8.8 SOD1 PRNP PRND PRDM10 GFAP APP

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Whey Protein
2 Caseins
3 Soy Bean

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Terminated NCT02072057 Phase 2 Ruxolitinib
2 The Effects of Exercise on the Metabolic Fate of Branched Chain Amino Acids in Relation to Aging and Chronic Disease. Completed NCT01418469

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

40
Brain, Testes, Lymph Node, Tonsil, T Cells, Skeletal Muscle, B Cells

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 658)
# Title Authors PMID Year
1
Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study. 61
32033521 2020
2
Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate species. 61
32008428 2020
3
Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus). 61
31852336 2020
4
Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk. 61
31973662 2020
5
Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates. 61
31910440 2020
6
A General Mass Spectrometry-Based Method of Quantitating Prion Polymorphisms from Heterozygous Chronic Wasting Disease-Infected Cervids. 61
31815434 2020
7
Characterization of serotonin following exposure to antibiotics in white-tailed deer. 61
31473183 2020
8
Revisiting Hunter Perceptions toward Chronic Wasting Disease: Changes in Behavior over Time. 61
31978950 2020
9
Chronic Wasting Disease: Current Assessment of Transmissibility. 61
31496519 2020
10
Introduction to Current Progress in Advanced Research on Prions. 61
31559970 2020
11
Genetic Factors in Mammalian Prion Diseases. 61
31537104 2019
12
Partnering with Taxidermists for Improved Chronic Wasting Disease Surveillance. 61
31835654 2019
13
The Effect of Chronic Wasting Disease on Resident Deer Hunting Permit Demand in Wisconsin. 61
31817847 2019
14
Environmental challenges for the nervous system and the brain in Japan. 61
31627893 2019
15
Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids. 61
31819115 2019
16
In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease. 61
31846418 2019
17
Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease. 61
31873177 2019
18
Cellular distribution of the prion protein in palatine tonsils of mule deer (Odocoileus hemionus) and Rocky Mountain elk (Cervus elaphus nelsoni). 61
31548473 2019
19
Novel Spiroplasma sp. Isolated From CWD Is an Extreme Bacterial Thermoacidophile That Survives Autoclaving, Boiling, Formalin Treatment, and Significant Gamma Irradiation. 61
31512718 2019
20
Differential gene expression in chronic wasting disease-positive white-tailed deer (Odocoileus virginianus). 61
31788200 2019
21
The ecology of chronic wasting disease in wildlife. 61
31750623 2019
22
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons. 61
31641070 2019
23
Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease. 61
31788624 2019
24
First Detection of Chronic Wasting Disease in a Wild Red Deer (Cervus elaphus) in Europe. 61
30920905 2019
25
Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression. 61
31553058 2019
26
Gene-edited murine cell lines for propagation of chronic wasting disease prions. 61
31371793 2019
27
Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier. 61
30592012 2019
28
Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species. 61
31337719 2019
29
Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe. 61
31366372 2019
30
Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice. 61
31147460 2019
31
Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages. 61
30831227 2019
32
An autopsy case of peliosis hepatis with X-linked myotubular myopathy. 61
31030121 2019
33
Estimating the amount of Chronic Wasting Disease infectivity passing through abattoirs and field slaughter. 61
30935503 2019
34
BSE infectivity survives burial for five years with only limited spread. 61
30799509 2019
35
Raccoons accumulate PrPSc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie. 61
30694116 2019
36
Animal prion diseases: the risks to human health. 61
30588682 2019
37
Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPCWD deposition in orally infected white-tailed deer. 61
30717795 2019
38
Development of an antigen ELISA using monoclonal antibodies against recombinant VSG for the detection of active infections of Trypanosoma evansi in animals. 61
30736948 2019
39
Rapid recontamination of a farm building occurs after attempted prion removal. 61
30602491 2019
40
Sodium hydroxide treatment effectively inhibits PrPCWD replication in farm soil. 61
31258051 2019
41
Use of faecal volatile organic compound analysis for ante-mortem discrimination between CWD-positive, -negative exposed, and -known negative white-tailed deer (Odocoileus virginianus). 61
31032718 2019
42
Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles. 61
31790424 2019
43
In Vitro detection of Chronic Wasting Disease (CWD) prions in semen and reproductive tissues of white tailed deer bucks (Odocoileus virginianus). 61
31887141 2019
44
Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay. 61
30670087 2019
45
Quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents. 61
31830760 2019
46
Cellular and Molecular Mechanisms of Prion Disease. 61
30355150 2019
47
RECENT CHANGES IN INFECTIOUS DISEASES IN EUROPEAN WILDLIFE. 61
30284963 2019
48
Inactivation of chronic wasting disease prions using sodium hypochlorite. 61
31584997 2019
49
Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool. 61
31071138 2019
50
Spatial heterogeneity of prion gene polymorphisms in an area recently infected by chronic wasting disease. 61
30777498 2019

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

Pathways related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SOD1 SCN2A PRNP GFAP APP
2 10.86 SOD1 PRNP APP
3 10.57 PRNP APP

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 anchored component of membrane GO:0031225 9.33 SPRN PRNP PRND
2 anchored component of external side of plasma membrane GO:0031362 8.96 PRNP PRND
3 astrocyte projection GO:0097449 8.62 GFAP APP

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.58 SOD1 PRNP APP
2 cellular response to copper ion GO:0071280 9.46 PRNP APP
3 regulation of multicellular organism growth GO:0040014 9.43 SOD1 APP
4 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.37 PRNP APP
5 response to copper ion GO:0046688 9.32 SOD1 PRNP
6 negative regulation of long-term synaptic potentiation GO:1900272 9.26 PRNP APP
7 neuron projection maintenance GO:1990535 9.16 PRNP APP
8 modulation of age-related behavioral decline GO:0090647 8.96 PRNP APP
9 cellular copper ion homeostasis GO:0006878 8.8 PRNP PRND APP

Molecular functions related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.8 SOD1 PRNP PRND

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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