MCID: CHR028
MIFTS: 33

Chronic Wasting Disease

Categories: Neuronal diseases

Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 44 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 44 D034081
UMLS 71 C1135993

Summaries for Chronic Wasting Disease

CDC : 3 Chronic wasting disease (CWD) is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, including Canada and the United States, Norway and South Korea. It may take over a year before an infected animal develops symptoms, which can include drastic weight loss (wasting), stumbling, listlessness and other neurologic symptoms. CWD can affect animals of all ages and some infected animals may die without ever developing the disease. CWD is fatal to animals and there are no treatments or vaccines. To date, there have been no reported cases of CWD infection in people. However, some animal studies suggest CWD poses a risk to certain types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain.

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to prion disease and kuru, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. Affiliated tissues include tonsil, t cells and whole blood, and related phenotype is behavior/neurological.

Wikipedia : 74 Chronic wasting disease (CWD), sometimes called zombie deer disease, is a transmissible spongiform... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 prion disease 31.3 SPRN SOD1 SNCA PRNP PRND MSMB
2 kuru 30.4 SPRN SOD1 SNCA SCN2A PRNP PRND
3 amyloidosis 29.9 SNCA SERPINA3 PRNP APP
4 scrapie 29.7 SPRN SNCA SERPINA3 SCN2A RPSA PRNP
5 creutzfeldt-jakob disease 29.6 SPRN SNCA SERPINA3 RPSA PRNP PRND
6 alzheimer disease 28.7 SOD1 SNCA SERPINA3 PRNP PRND GFAP
7 encephalopathy 10.8
8 ideomotor apraxia 10.3 SNCA PRNP
9 interdigitating dendritic cell sarcoma 10.3 SERPINA3 CR2
10 akinetic mutism 10.3 SNCA PRNP
11 histiocytic and dendritic cell cancer 10.3 SERPINA3 CR2
12 partial motor epilepsy 10.3 SERPINA3 SCN2A
13 chromosome 17q21.31 duplication syndrome 10.2 SNCA APP
14 disease by infectious agent 10.2
15 alzheimer disease 18 10.2 SNCA APP
16 dysautonomia 10.2 SNCA PRNP
17 hemoglobin e disease 10.2 SERPINA3 SCN2A
18 adult xanthogranuloma 10.2 SERPINA3 CR2
19 platelet aggregation, spontaneous 10.2 SOD1 SERPINA3
20 cerebral amyloid angiopathy, itm2b-related, 1 10.2 SERPINA3 PRNP APP
21 actinobacillosis 10.2 CR2 APP
22 amyloidosis, hereditary, transthyretin-related 10.2 SNCA PRNP APP
23 aphasia 10.1 SNCA PRNP APP
24 cerebellopontine angle primitive neuroectodermal tumor 10.1 GFAP CR2
25 arteriolosclerosis 10.1 SNCA SERPINA3 APP
26 communicating hydrocephalus 10.1 SNCA SERPINA3 APP
27 endobronchial leiomyoma 10.1 GFAP CR2
28 syringocystadenoma papilliferum 10.1 SERPINA3 GFAP
29 alzheimer disease 2 10.1 SERPINA3 APP
30 ciliary dyskinesia, primary, 26 10.1 SOD1 APP
31 alzheimer disease 7 10.1 SOD1 SNCA
32 ataxia and polyneuropathy, adult-onset 10.0
33 bruxism 10.0
34 cerebral amyloid angiopathy, cst3-related 10.0 SNCA SERPINA3 PRNP APP
35 mild cognitive impairment 10.0 SOD1 APP
36 binswanger's disease 10.0 GFAP APP
37 movement disease 10.0 SNCA SERPINA3 SCN2A APP
38 wilson disease 9.9 SOD1 PRNP APP
39 myositis 9.9 SNCA SERPINA3 APP
40 normal pressure hydrocephalus 9.9 SERPINA3 GFAP APP
41 multiple system atrophy 1 9.9 SNCA SERPINA3 PRNP GFAP
42 spastic paraplegia 38, autosomal dominant 9.9 SOD1 GFAP
43 sweat gland benign neoplasm 9.9 SERPINA3 GFAP
44 alzheimer disease 9 9.9 SOD1 SNCA
45 helix syndrome 9.9
46 endometrial hyperplasia 9.9
47 endometritis 9.9
48 mastitis 9.9
49 brucellosis 9.9
50 myiasis 9.9

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

MGI Mouse Phenotypes related to Chronic Wasting Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.36 APP DMRTA1 GFAP OMP PRND PRNP

Drugs & Therapeutics for Chronic Wasting Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Terminated NCT02072057 Phase 2 Ruxolitinib

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

40
Tonsil, T Cells, Whole Blood, Lymph Node, Retina, Colon, Kidney

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 714)
# Title Authors PMID Year
1
Time of Detection of Prions in the Brain by Nanoscale Liquid Chromatography Coupled to Tandem Mass Spectrometry Is Comparable to Animal Bioassay. 61
33586964 2021
2
[Problems of ante mortem diagnostics of prion diseases]. 61
33533229 2021
3
Humanised transgenic mice are resistant to chronic wasting disease prions from Norwegian reindeer and moose. 61
33502474 2021
4
Chronic Wasting Disease (CWD) in Sami Reindeer Herding: The Socio-Political Dimension of an Epizootic in an Indigenous Context. 61
33503846 2021
5
Geographic variation in the PRNP gene and its promoter, and their relationship to chronic wasting disease in North American deer. 61
32715865 2020
6
Association of chronic wasting disease susceptibility with prion protein variation in white-tailed deer (Odocoileus virginianus). 61
32835598 2020
7
Replication of Small Ruminant Lentiviruses in Aluminum Hydroxide-Induced Granulomas in Sheep: a Potential New Factor for Viral Dissemination. 61
33115880 2020
8
Prion Protein Gene (PRNP) Sequences Suggest Differing Vulnerability to Chronic Wasting Disease for Florida Key Deer (Odocoileus virginianus clavium) and Columbian White-Tailed Deer (O. v. leucurus). 61
32945850 2020
9
Successful transmission of the chronic wasting disease (CWD) agent to white-tailed deer by intravenous blood transfusion. 61
33129572 2020
10
Age structuring and spatial heterogeneity in prion protein gene (PRNP) polymorphism in white-tailed deer. 61
33078661 2020
11
Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate species. 61
32008428 2020
12
Seroprevalence of Mycobacteriumavium subsp. paratuberculosis in Dairy Cattle in Khartoum State, Sudan. 61
33371490 2020
13
Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus). 61
31852336 2020
14
Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk. 61
31973662 2020
15
Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates. 61
33345717 2020
16
Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study. 61
32033521 2020
17
Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America. 61
33229531 2020
18
Experimental oral transmission of chronic wasting disease to sika deer (Cervus nippon). 61
33300452 2020
19
Exposure Risk of Chronic Wasting Disease in Humans. 61
33348562 2020
20
Antler cannibalism in reindeer. 61
33335134 2020
21
Met166 -Glu168 residues in human PrP β2-α2 loop account for evolutionary resistance to prion infection. 61
33253417 2020
22
The European Union summary report on surveillance for the presence of transmissible spongiform encephalopathies (TSE) in 2019. 61
33235634 2020
23
Chronic wasting disease (CWD) prion detection in blood from pre-symptomatic white-tailed deer harboring PRNP polymorphic variants. 61
33188252 2020
24
HUNTING PRESSURE MODULATES PRION INFECTION RISK IN MULE DEER HERDS. 61
33600602 2020
25
A RETROSPECTIVE SUMMARY OF CERVID MORBIDITY AND MORTALITY IN ONTARIO AND NUNAVUT REGIONS OF CANADA (1991-2017). 61
32348201 2020
26
CHRONIC WASTING DISEASE MODELING: AN OVERVIEW. 61
32544029 2020
27
Spatial analysis of chronic wasting disease in free-ranging white-tailed deer (Odocoileus virginianus) in Illinois, 2008-2019. 61
33112021 2020
28
Large-scale prion protein genotyping in Canadian caribou populations and potential impact on chronic wasting disease susceptibility. 61
32810895 2020
29
Genetic and evolutionary considerations of the Chronic Wasting Disease - Human species barrier. 61
32731042 2020
30
Implications of farmed-cervid movements on the transmission of chronic wasting disease. 61
32673935 2020
31
Is There a Breach in the Barrier Protecting Humans from Cervid Chronic Wasting Disease? 61
32873762 2020
32
Failure To Detect Prion Infectivity in Ticks following Prion-Infected Blood Meal. 61
32878935 2020
33
Hunting strategies to increase detection of chronic wasting disease in cervids. 61
32873810 2020
34
Chronic wasting disease undermines efforts to control the spread of brucellosis in the Greater Yellowstone Ecosystem. 61
32223053 2020
35
Early detection of prion protein aggregation with a fluorescent pentameric oligothiophene probe using spectral confocal microscopy. 61
32799317 2020
36
Identification of the prion-related protein gene (PRNT) sequences in various species of the Cervidae family. 61
32737828 2020
37
The unique spatial ecology of human hunters. 61
32203320 2020
38
EFFECT OF ORAL COPPER SUPPLEMENTATION ON SUSCEPTIBILITY IN WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) TO CHRONIC WASTING DISEASE. 61
32073993 2020
39
The complete mitochondrial genome of Cervus canadensis (Erxleben, 1777), as a model species of Chronic Wasting Disease (CWD). 61
33457884 2020
40
Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination. 61
32513872 2020
41
Molecular dynamics studies of dog prion protein wild-type and its D159N mutant. 61
32496928 2020
42
[Effects of SGI-1027 on Formation and Elimination of PrP^(Sc) in Prion-Infected Cells]. 61
32492010 2020
43
An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development. 61
32376941 2020
44
Assessment of spatial genetic structure to identify populations at risk for infection of an emerging epizootic disease. 61
32489625 2020
45
Long-Term Incubation PrPCWD with Soils Affects Prion Recovery but Not Infectivity. 61
32340296 2020
46
Can genetic assignment tests provide insight on the influence of captive egression on the epizootiology of chronic wasting disease? 61
32211062 2020
47
Accurate Genomic Predictions for Chronic Wasting Disease in U.S. White-Tailed Deer. 61
32122960 2020
48
Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms. 61
32111742 2020
49
The ecology of chronic wasting disease in wildlife. 61
31750623 2020
50
Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression. 61
31553058 2020

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

Pathways related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 SOD1 SNCA SCN2A PRNP GFAP APP
2 10.86 SOD1 PRNP APP

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial matrix GO:0005759 9.62 UQCC2 SSBP1 SOD1 SNCA
2 anchored component of membrane GO:0031225 9.54 SPRN PRNP PRND
3 inclusion body GO:0016234 9.26 SNCA PRNP
4 anchored component of external side of plasma membrane GO:0031362 9.16 PRNP PRND
5 astrocyte projection GO:0097449 8.96 GFAP APP
6 mitochondrial intermembrane space GO:0005758 8.8 UQCC2 SOD1 SNCA

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.65 SOD1 PRNP APP
2 platelet degranulation GO:0002576 9.61 SOD1 SERPINA3 APP
3 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.46 PRNP APP
4 regulation of long-term neuronal synaptic plasticity GO:0048169 9.4 SNCA APP
5 response to copper ion GO:0046688 9.37 SOD1 PRNP
6 negative regulation of long-term synaptic potentiation GO:1900272 9.32 PRNP APP
7 neuron projection maintenance GO:1990535 9.26 PRNP APP
8 modulation of age-related behavioral decline GO:0090647 9.16 PRNP APP
9 cellular response to copper ion GO:0071280 9.13 SNCA PRNP APP
10 cellular copper ion homeostasis GO:0006878 8.8 PRNP PRND APP

Molecular functions related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cuprous ion binding GO:1903136 8.96 SNCA PRNP
2 copper ion binding GO:0005507 8.92 SOD1 SNCA PRNP PRND

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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