MCID: CHR028
MIFTS: 29

Chronic Wasting Disease

Categories: Neuronal diseases

Aliases & Classifications for Chronic Wasting Disease

MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:3530
MeSH 45 D034081
UMLS 74 C1135993

Summaries for Chronic Wasting Disease

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to scrapie and prion disease, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways is B cell receptor signaling pathway (KEGG). The drugs Caseins and Soy Bean have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node.

Wikipedia : 77 Chronic wasting disease (CWD) is a prion disease affecting cervids, the deer family, and belongs to a... more...

Related Diseases for Chronic Wasting Disease

Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 scrapie 31.7 PRNP SPRN
2 prion disease 31.5 CR2 PRNP SPRN
3 kuru 31.3 ERC1 PRNP
4 creutzfeldt-jakob disease 29.2 PRNP SPRN
5 encephalopathy 10.3
6 pityriasis rubra pilaris 10.3
7 buschke-ollendorff syndrome 9.8
8 lymphocytic choriomeningitis 9.8
9 genetic prion diseases 9.8

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease

Symptoms & Phenotypes for Chronic Wasting Disease

UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

Drugs & Therapeutics for Chronic Wasting Disease

Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins Not Applicable
2 Soy Bean Not Applicable
3 Whey Protein Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Terminated NCT02072057 Phase 2 Ruxolitinib
2 Disturbances in BCAA Metabolism and the Effects of Feeding and Exercise in COPD Completed NCT01418469 Not Applicable
3 Sarcopenia and Visceral Obesity in Esophageal and Gastric Cancer Active, not recruiting NCT03061370

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

Genetic Tests for Chronic Wasting Disease

Anatomical Context for Chronic Wasting Disease

MalaCards organs/tissues related to Chronic Wasting Disease:

42
Brain, Testes, Lymph Node, Skeletal Muscle, Tonsil, Heart, Retina

Publications for Chronic Wasting Disease

Articles related to Chronic Wasting Disease:

(show top 50) (show all 289)
# Title Authors Year
1
Transmission studies of chronic wasting disease to transgenic mice overexpressing human prion protein using the RT-QuIC assay. ( 30670087 )
2019
2
Raccoons accumulate PrPSc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie. ( 30694116 )
2019
3
Spatial heterogeneity of prion gene polymorphisms in an area recently infected by chronic wasting disease. ( 30777498 )
2019
4
First Detection of Chronic Wasting Disease in a Wild Red Deer ( Cervus elaphus) in Europe. ( 30920905 )
2019
5
Estimating the amount of Chronic Wasting Disease infectivity passing through abattoirs and field slaughter. ( 30935503 )
2019
6
Comparison of conventional, amplification and bio-assay detection methods for a chronic wasting disease inoculum pool. ( 31071138 )
2019
7
Pathologic and biochemical characterization of PrPSc from elk with PRNP polymorphisms at codon 132 after experimental infection with the chronic wasting disease agent. ( 29523205 )
2018
8
Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids. ( 29580373 )
2018
9
EVALUATION OF A TEST AND CULL STRATEGY FOR REDUCING PREVALENCE OF CHRONIC WASTING DISEASE IN MULE DEER ( ODOCOILEUS HEMIONUS). ( 29667874 )
2018
10
Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques. ( 29695429 )
2018
11
CATTLE ( BOS TAURUS) RESIST CHRONIC WASTING DISEASE FOLLOWING ORAL INOCULATION CHALLENGE OR TEN YEARS' NATURAL EXPOSURE IN CONTAMINATED ENVIRONMENTS. ( 29715064 )
2018
12
Mineral licks as environmental reservoirs of chronic wasting disease prions. ( 29719000 )
2018
13
Chronic wasting disease: an evolving prion disease of cervids. ( 29887133 )
2018
14
Modified Protein Misfolding Cyclic Amplification Overcomes Real-Time Quaking-Induced Conversion Assay Inhibitors in Deer Saliva To Detect Chronic Wasting Disease Prions. ( 29950332 )
2018
15
A reindeer cull to prevent chronic wasting disease in Europe. ( 29988166 )
2018
16
Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions. ( 30014840 )
2018
17
Influence of the geographic distribution of prion protein gene sequence variation on patterns of chronic wasting disease spread in white-tailed deer (Odocoileus virginianus). ( 30041562 )
2018
18
Recombinant prion protein vaccination of transgenic elk PrP mice and reindeer overcomes self-tolerance and protects mice against chronic wasting disease. ( 30397182 )
2018
19
Accelerated onset of chronic wasting disease in elk (Cervus canadensis) vaccinated with a PrPSc-specific vaccine and housed in a prion contaminated environment. ( 30414779 )
2018
20
Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway. ( 30457526 )
2018
21
Chronic wasting disease management in ranched elk using rectal biopsy testing. ( 29424295 )
2018
22
Contact tracing for the control of infectious disease epidemics: Chronic Wasting Disease in deer farms. ( 29329958 )
2018
23
Assessment of Chronic Wasting Disease Prion Shedding in Deer Saliva with Occupancy Modeling. ( 29118163 )
2018
24
Molecular Mechanisms of Chronic Wasting Disease Prion Propagation. ( 28193766 )
2018
25
Current evidence on the transmissibility of chronic wasting disease prions to humans-A systematic review. ( 28139079 )
2018
26
Clay content and pH: soil characteristic associations with the persistent presence of chronic wasting disease in northern Illinois. ( 29273783 )
2017
27
Detection of Prions in Blood of Cervids at the Asymptomatic Stage of Chronic Wasting Disease. ( 29222449 )
2017
28
Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice. ( 29105545 )
2017
29
Ante-mortem detection of chronic wasting disease in recto-anal mucosa-associated lymphoid tissues from elk (Cervus elaphus nelsoni) using real-time quaking-induced conversion (RT-QuIC) assay: A blinded collaborative study. ( 29098931 )
2017
30
Chronic wasting disease: Emerging prions and their potential risk. ( 29095921 )
2017
31
Pathogen-mediated selection in free-ranging elk populations infected by chronic wasting disease. ( 29087314 )
2017
32
Estimating chronic wasting disease susceptibility in cervids using real-time quaking-induced conversion. ( 29058651 )
2017
33
Endemic chronic wasting disease causes mule deer population decline in Wyoming. ( 29049389 )
2017
34
Induction of PrPSc-specific systemic and mucosal immune responses in white-tailed deer with an oral vaccine for chronic wasting disease. ( 28968152 )
2017
35
Immunization of cervidized transgenic mice with multimeric deer prion protein induces self-antibodies that antagonize chronic wasting disease infectivity in vitro. ( 28874781 )
2017
36
Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion. ( 28820384 )
2017
37
Evolution of Diagnostic Tests for Chronic Wasting Disease, a Naturally Occurring Prion Disease of Cervids. ( 28783058 )
2017
38
Chronic wasting disease prion infection of differentiated neurospheres. ( 28762865 )
2017
39
Temporal patterns of chronic wasting disease prion excretion in three cervid species. ( 28708047 )
2017
40
Detection of chronic wasting disease prion seeding activity in deer and elk feces by real-time quaking-induced conversion. ( 28703697 )
2017
41
Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation. ( 28701407 )
2017
42
Infectious Prions in the Pregnancy Microenvironment of Chronic Wasting Disease-Infected Reeves' Muntjac Deer. ( 28539446 )
2017
43
High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population. ( 28350512 )
2017
44
Pathways of Prion Spread during Early Chronic Wasting Disease in Deer. ( 28250130 )
2017
45
Chronic wasting disease in white-tailed deer: infection, mortality, and implications for heterogeneous transmission. ( 27870037 )
2016
46
Horizontal Transmission of Chronic Wasting Disease in Reindeer. ( 27869594 )
2016
47
Early and Non-Invasive Detection of Chronic Wasting Disease Prions in Elk Feces by Real-Time Quaking Induced Conversion. ( 27829062 )
2016
48
Modeled Impacts of Chronic Wasting Disease on White-Tailed Deer in a Semi-Arid Environment. ( 27711208 )
2016
49
First case of chronic wasting disease in Europe in a Norwegian free-ranging reindeer. ( 27641251 )
2016
50
Chronic Wasting Disease Drives Population Decline of White-Tailed Deer. ( 27575545 )
2016

Variations for Chronic Wasting Disease

Expression for Chronic Wasting Disease

Search GEO for disease gene expression data for Chronic Wasting Disease.

Pathways for Chronic Wasting Disease

Pathways related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11 CR2 PIP5K1C

GO Terms for Chronic Wasting Disease

Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.43 CR2 ERC1 PIP5K1C PRNP SPRN UQCC2
2 anchored component of membrane GO:0031225 8.62 PRNP SPRN

Sources for Chronic Wasting Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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