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MCID: CHR028
MIFTS: 35

Chronic Wasting Disease

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Chronic Wasting Disease

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MalaCards integrated aliases for Chronic Wasting Disease:

Name: Chronic Wasting Disease 12 3 15
Wasting Disease, Chronic 43 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3530
MeSH 43 D034081
UMLS 71 C1135993
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Summaries for Chronic Wasting Disease

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CDC : 3 Chronic wasting disease (CWD) is a prion disease that affects deer, elk, reindeer, sika deer and moose. It has been found in some areas of North America, including Canada and the United States, Norway and South Korea. It may take over a year before an infected animal develops symptoms, which can include drastic weight loss (wasting), stumbling, listlessness and other neurologic symptoms. CWD can affect animals of all ages and some infected animals may die without ever developing the disease. CWD is fatal to animals and there are no treatments or vaccines. To date, there have been no reported cases of CWD infection in people. However, some animal studies suggest CWD poses a risk to certain types of non-human primates, like monkeys, that eat meat from CWD-infected animals or come in contact with brain or body fluids from infected deer or elk. These studies raise concerns that there may also be a risk to people. Since 1997, the World Health Organization has recommended that it is important to keep the agents of all known prion diseases from entering the human food chain.

MalaCards based summary : Chronic Wasting Disease, also known as wasting disease, chronic, is related to kuru and prion disease, and has symptoms including lameness, animal An important gene associated with Chronic Wasting Disease is PRNP (Prion Protein), and among its related pathways/superpathways are Neuroscience and Copper homeostasis. The drugs Caseins and Whey Protein have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and lymph node, and related phenotypes are behavior/neurological and mortality/aging

Wikipedia : 74 Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting deer. TSEs... more...

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Related Diseases for Chronic Wasting Disease

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Diseases related to Chronic Wasting Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 kuru 30.1 SPRN SOD1 SNCA SCN2A PRNP PRND
2 prion disease 29.7 SPRN SOD1 SNCA SCN2A RPSA PRNP
3 scrapie 29.2 SPRN SNCA SCN2A RPSA PRNP PRND
4 creutzfeldt-jakob disease 29.2 SPRN SNCA RPSA PRNP PRND PRDM10
5 encephalopathy 10.7
6 akinetic mutism 10.3 SNCA PRNP
7 chromosome 17q21.31 duplication syndrome 10.3 SNCA APP
8 cerebellopontine angle primitive neuroectodermal tumor 10.3 GFAP CR2
9 alzheimer disease 18 10.3 SNCA APP
10 familial febrile seizures 10.2 SCN2A PRND PRDM10
11 haemonchiasis 10.2 PRDM10 HUWE1
12 dysautonomia 10.2 SNCA PRNP
13 endobronchial leiomyoma 10.2 GFAP CR2
14 aphasia 10.2 SNCA PRNP APP
15 cerebral amyloid angiopathy, cst3-related 10.1 SNCA PRNP APP
16 primary lateral sclerosis, adult, 1 10.1 SOD1 SNCA
17 multiple system atrophy 1 10.1 SNCA PRNP GFAP
18 binswanger's disease 10.1 GFAP APP
19 arteriolosclerosis 10.0 SNCA APP
20 ciliary dyskinesia, primary, 26 10.0 SOD1 APP
21 bruxism 9.9
22 olfactory nerve neoplasm 9.9 OMP GFAP
23 cranial nerve malignant neoplasm 9.9 OMP GFAP
24 leukoencephalopathy, hereditary diffuse, with spheroids 9.9 SNCA PRNP GFAP APP
25 cranial nerve neoplasm 9.9 OMP GFAP
26 wilson disease 9.8 SOD1 PRNP APP
27 vascular dementia 9.8 SOD1 PRNP APP
28 parkinson disease 4, autosomal dominant 9.8 SNCA HUWE1
29 central nervous system disease 9.8 SNCA PRNP GFAP APP
30 metachromatic leukodystrophy 9.8 PRDM10 HUWE1 GFAP
31 alzheimer disease 9.8
32 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
33 ataxia and polyneuropathy, adult-onset 9.8
34 helix syndrome 9.8
35 endometrial hyperplasia 9.8
36 endometritis 9.8
37 mastitis 9.8
38 brucellosis 9.8
39 myiasis 9.8
40 rabies 9.8
41 lymphocytic choriomeningitis 9.8
42 gastroenteritis 9.8
43 neuroaxonal dystrophy 9.8
44 amyloidosis 9.8
45 47,xyy 9.8
46 tremor 9.8
47 acquired human prion disease 9.8
48 spastic paraplegia 38, autosomal dominant 9.7 SOD1 GFAP
49 kagami-ogata syndrome 9.7 PRDM10 HUWE1 GFAP
50 amyloidosis, hereditary, transthyretin-related 9.7 SOD1 SNCA PRNP APP

Graphical network of the top 20 diseases related to Chronic Wasting Disease:



Diseases related to Chronic Wasting Disease
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Symptoms & Phenotypes for Chronic Wasting Disease

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UMLS symptoms related to Chronic Wasting Disease:


lameness, animal

MGI Mouse Phenotypes related to Chronic Wasting Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 APP DMRTA1 ERI3 GFAP OMP PRND
2 mortality/aging MP:0010768 9.44 APP CR2 GFAP HUWE1 OMP PRDM10
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Drugs & Therapeutics for Chronic Wasting Disease

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Drugs for Chronic Wasting Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins
2 Whey Protein
3 Soy Bean

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The RUXexia Trial: An Open-label Phase II Trial of Ruxolitinib in the Treatment of Cachexia in Patients With Tumor-Associated Chronic Wasting Diseases. Terminated NCT02072057 Phase 2 Ruxolitinib
2 The Effects of Exercise on the Metabolic Fate of Branched Chain Amino Acids in Relation to Aging and Chronic Disease. Completed NCT01418469

Search NIH Clinical Center for Chronic Wasting Disease

Cochrane evidence based reviews: wasting disease, chronic

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Genetic Tests for Chronic Wasting Disease

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Anatomical Context for Chronic Wasting Disease

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MalaCards organs/tissues related to Chronic Wasting Disease:

40
Brain, Testes, Lymph Node, Tonsil, T Cells, Skeletal Muscle, B Cells
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Publications for Chronic Wasting Disease

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Articles related to Chronic Wasting Disease:

(show top 50) (show all 677)
# Title Authors PMID Year
1
Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus). 61
31852336 2020
2
Predicting the spread-risk potential of chronic wasting disease to sympatric ungulate species. 61
32008428 2020
3
Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study. 61
32033521 2020
4
Cross-validation of the RT-QuIC assay for the antemortem detection of chronic wasting disease in elk. 61
31973662 2020
5
Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination. 61
32513872 2020
6
CHRONIC WASTING DISEASE MODELING: AN OVERVIEW. 61
32544029 2020
7
Molecular dynamics studies of dog prion protein wild-type and its D159N mutant. 61
32496928 2020
8
Assessment of spatial genetic structure to identify populations at risk for infection of an emerging epizootic disease. 61
32489625 2020
9
[Effects of SGI-1027 on Formation and Elimination of PrP^(Sc) in Prion-Infected Cells]. 61
32492010 2020
10
An Ex Vivo Brain Slice Culture Model of Chronic Wasting Disease: Implications for Disease Pathogenesis and Therapeutic Development. 61
32376941 2020
11
Can genetic assignment tests provide insight on the influence of captive egression on the epizootiology of chronic wasting disease? 61
32211062 2020
12
Chronic wasting disease (CWD) prion strains evolve via adaptive diversification of conformers in hosts expressing prion protein polymorphisms. 61
32111742 2020
13
Long-Term Incubation PrPCWD with Soils Affects Prion Recovery but Not Infectivity. 61
32340296 2020
14
The ecology of chronic wasting disease in wildlife. 61
31750623 2020
15
Accurate Genomic Predictions for Chronic Wasting Disease in U.S. White-Tailed Deer. 61
32122960 2020
16
A RETROSPECTIVE SUMMARY OF CERVID MORBIDITY AND MORTALITY IN ONTARIO AND NUNAVUT REGIONS OF CANADA (1991-2017). 61
32348201 2020
17
Chronic wasting disease undermines efforts to control the spread of brucellosis in the Greater Yellowstone Ecosystem. 61
32223053 2020
18
The unique spatial ecology of human hunters. 61
32203320 2020
19
Cellulose ether treatment in vivo generates chronic wasting disease prions with reduced protease resistance and delayed disease progression. 61
31553058 2020
20
In vitro detection of haematogenous prions in white-tailed deer orally dosed with low concentrations of chronic wasting disease. 61
31846418 2020
21
An agent-based framework for improving wildlife disease surveillance: A case study of chronic wasting disease in Missouri white-tailed deer. 61
32189826 2020
22
EFFECT OF ORAL COPPER SUPPLEMENTATION ON SUSCEPTIBILITY IN WHITE-TAILED DEER (ODOCOILEUS VIRGINIANUS) TO CHRONIC WASTING DISEASE. 61
32073993 2020
23
Novel Strain of the Chronic Wasting Disease Agent Isolated From Experimentally Inoculated Elk With LL132 Prion Protein. 61
32081886 2020
24
Control and Surveillance Operations to Prevent Chronic Wasting Disease Establishment in Free-Ranging White-Tailed Deer in Québec, Canada. 61
32059390 2020
25
Progression of chronic wasting disease in white-tailed deer analyzed by serial biopsy RT-QuIC and immunohistochemistry. 61
32059005 2020
26
Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates. 61
31910440 2020
27
A General Mass Spectrometry-Based Method of Quantitating Prion Polymorphisms from Heterozygous Chronic Wasting Disease-Infected Cervids. 61
31815434 2020
28
Characterization of serotonin following exposure to antibiotics in white-tailed deer. 61
31473183 2020
29
Chronic Wasting Disease: Current Assessment of Transmissibility. 61
31496519 2020
30
Revisiting Hunter Perceptions toward Chronic Wasting Disease: Changes in Behavior over Time. 61
31978950 2020
31
Introduction to Current Progress in Advanced Research on Prions. 61
31559970 2020
32
Genetic Factors in Mammalian Prion Diseases. 61
31537104 2019
33
The Effect of Chronic Wasting Disease on Resident Deer Hunting Permit Demand in Wisconsin. 61
31817847 2019
34
Partnering with Taxidermists for Improved Chronic Wasting Disease Surveillance. 61
31835654 2019
35
Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids. 61
31819115 2019
36
Environmental challenges for the nervous system and the brain in Japan. 61
31627893 2019
37
Identification of circulating microRNA signatures as potential biomarkers in the serum of elk infected with chronic wasting disease. 61
31873177 2019
38
Cellular distribution of the prion protein in palatine tonsils of mule deer (Odocoileus hemionus) and Rocky Mountain elk (Cervus elaphus nelsoni). 61
31548473 2019
39
Novel Spiroplasma sp. Isolated From CWD Is an Extreme Bacterial Thermoacidophile That Survives Autoclaving, Boiling, Formalin Treatment, and Significant Gamma Irradiation. 61
31512718 2019
40
Differential gene expression in chronic wasting disease-positive white-tailed deer (Odocoileus virginianus). 61
31788200 2019
41
Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons. 61
31641070 2019
42
Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease. 61
31788624 2019
43
First Detection of Chronic Wasting Disease in a Wild Red Deer (Cervus elaphus) in Europe. 61
30920905 2019
44
Gene-edited murine cell lines for propagation of chronic wasting disease prions. 61
31371793 2019
45
Insights into the Bidirectional Properties of the Sheep-Deer Prion Transmission Barrier. 61
30592012 2019
46
Chronic Wasting Disease in Cervids: Implications for Prion Transmission to Humans and Other Animal Species. 61
31337719 2019
47
Variation in the prion protein gene (PRNP) sequence of wild deer in Great Britain and mainland Europe. 61
31366372 2019
48
Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice. 61
31147460 2019
49
Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages. 61
30831227 2019
50
An autopsy case of peliosis hepatis with X-linked myotubular myopathy. 61
31030121 2019
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Variations for Chronic Wasting Disease

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Expression for Chronic Wasting Disease

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Search GEO for disease gene expression data for Chronic Wasting Disease.
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Pathways for Chronic Wasting Disease

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Pathways related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.63 SOD1 SNCA SCN2A PRNP GFAP APP
2
Copper homeostasis 1
10.86 SOD1 PRNP APP
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GO Terms for Chronic Wasting Disease

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Cellular components related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inclusion body GO:0016234 9.26 SNCA PRNP
2 anchored component of external side of plasma membrane GO:0031362 9.16 PRNP PRND
3 astrocyte projection GO:0097449 8.96 GFAP APP
4 mitochondrial intermembrane space GO:0005758 8.8 UQCC2 SOD1 SNCA

Biological processes related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to oxidative stress GO:0006979 9.63 SOD1 PRNP APP
2 regulation of peptidyl-tyrosine phosphorylation GO:0050730 9.43 PRNP APP
3 regulation of long-term neuronal synaptic plasticity GO:0048169 9.4 SNCA APP
4 response to copper ion GO:0046688 9.37 SOD1 PRNP
5 negative regulation of long-term synaptic potentiation GO:1900272 9.32 PRNP APP
6 neuron projection maintenance GO:1990535 9.26 PRNP APP
7 modulation of age-related behavioral decline GO:0090647 9.16 PRNP APP
8 cellular response to copper ion GO:0071280 9.13 SNCA PRNP APP
9 cellular copper ion homeostasis GO:0006878 8.8 PRNP PRND APP

Molecular functions related to Chronic Wasting Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cuprous ion binding GO:1903136 8.96 SNCA PRNP
2 copper ion binding GO:0005507 8.92 SOD1 SNCA PRNP PRND
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Sources for Chronic Wasting Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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