MCID: CHR001
MIFTS: 51

Churg-Strauss Syndrome

Categories: Blood diseases, Cardiovascular diseases, Immune diseases

Aliases & Classifications for Churg-Strauss Syndrome

MalaCards integrated aliases for Churg-Strauss Syndrome:

Name: Churg-Strauss Syndrome 12 55 44 15 73
Allergic Granulomatosis Angiitis 12
Allergic Granulomatous Angiitis 12
Churg-Strauss Vasculitis 12
Churgstrauss Syndrome 76

Classifications:



External Ids:

Disease Ontology 12 DOID:3049
ICD10 33 M30.1
MeSH 44 D015267
NCIt 50 C34481
SNOMED-CT 68 82275008
UMLS 73 C0008728

Summaries for Churg-Strauss Syndrome

Disease Ontology : 12 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

MalaCards based summary : Churg-Strauss Syndrome, also known as allergic granulomatosis angiitis, is related to granulomatosis with polyangiitis and vasculitis, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is MPO (Myeloperoxidase), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Azathioprine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and colon.

Wikipedia : 76 Eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg�??Strauss syndrome (CSS) or... more...

Related Diseases for Churg-Strauss Syndrome

Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 291)
# Related Disease Score Top Affiliating Genes
1 granulomatosis with polyangiitis 31.3 HMGB1 MPO PRTN3
2 vasculitis 31.1 MPO PRTN3 THBD TNF
3 granulomatous angiitis 31.1 IL5 PRTN3 THBD
4 microscopic polyangiitis 31.0 IL10 MPO TNF
5 chronic eosinophilic pneumonia 30.9 IL5 RNASE3
6 eosinophilic pneumonia 30.8 CCL17 IL5 RNASE3
7 rapidly progressive glomerulonephritis 30.8 MPO PRTN3
8 endomyocardial fibrosis 30.7 IL10 TNF
9 eosinophilic gastroenteritis 30.6 IL5 RNASE3
10 hypereosinophilic syndrome 30.6 CCL17 IL5 RNASE3
11 asthma 30.4 CCL17 CCL26 IL10 IL5 MPO RNASE3
12 hypersensitivity vasculitis 30.4 MPO PRTN3
13 pneumonia 30.4 IL10 IL5 MPO TNF
14 scleritis 30.3 IL5 TNF
15 gastroenteritis 30.2 IL10 IL5 RNASE3 TNF
16 myocardial infarction 30.1 IL10 MPO THBD TNF
17 allergic bronchopulmonary aspergillosis 30.1 CCL17 IL5
18 cellulitis 30.1 IL5 RNASE3 TNF
19 otitis media 30.0 IL10 RNASE3 TNF
20 colitis 30.0 IL10 MPO TNF
21 aspergillosis 30.0 CCL17 IL10 IL5 TNF
22 ulcerative colitis 29.8 IL10 MPO PRTN3 TNF
23 appendicitis 29.7 HMGB1 IL10 MPO TNF
24 rheumatoid arthritis 29.7 HMGB1 IL10 PRTN3 TNF
25 eosinophilic granulomatosis with polyangiitis 12.5
26 allergic angiitis 12.4
27 neuropathy 10.8
28 polyarteritis nodosa, childhood-onset 10.8
29 polyarteritis nodosa 10.8
30 myocarditis 10.6
31 glomerulonephritis 10.6
32 peripheral nervous system disease 10.6
33 polyneuropathy 10.6
34 cholecystitis 10.5
35 retinal artery occlusion 10.5
36 central retinal artery occlusion 10.5
37 wells syndrome 10.5
38 thrombosis 10.5
39 mononeuritis multiplex 10.5
40 ischemia 10.5
41 temporal arteritis 10.5
42 hepatitis 10.4
43 crescentic glomerulonephritis 10.4
44 optic nerve disease 10.4
45 dilated cardiomyopathy 10.4
46 hemopericardium 10.4
47 pericardial effusion 10.4
48 branch retinal artery occlusion 10.4
49 viral infectious disease 10.4
50 cardiogenic shock 10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to Churg-Strauss Syndrome

Symptoms & Phenotypes for Churg-Strauss Syndrome

Symptoms:

12
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

Drugs for Churg-Strauss Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
3
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
6
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
7
leucovorin Approved Phase 4,Phase 2 58-05-9 6006 143
8
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
9
Methotrexate Approved Phase 4,Phase 2 59-05-2, 1959-05-2 126941
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
rituximab Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 174722-31-7 10201696
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
13
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
14 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
20 Antimetabolites Phase 4,Phase 3,Phase 2
21 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
22 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
23 Vitamin B9 Phase 4,Phase 2
24 Prednisolone acetate Phase 4,Phase 3,Not Applicable
25 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
26 Anti-Infective Agents Phase 4,Not Applicable
27 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
28 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
29 Antiemetics Phase 4,Phase 3,Not Applicable
30 Vitamin B Complex Phase 4,Phase 2
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Folic Acid Antagonists Phase 4,Phase 2
33 Methylprednisolone acetate Phase 4,Phase 3,Not Applicable
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
35 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
36 Dermatologic Agents Phase 4,Phase 2,Not Applicable
37 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
38 Protective Agents Phase 4,Phase 3,Not Applicable
39 Autonomic Agents Phase 4,Phase 3,Not Applicable
40 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
41 Folate Phase 4,Phase 2
42 Antitubercular Agents Phase 4
43 Antibiotics, Antitubercular Phase 4
44 Anti-Bacterial Agents Phase 4
45 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
47 Pharmaceutical Solutions Phase 3
48 Immunoglobulins, Intravenous Phase 3
49 gamma-Globulins Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
4 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3 Placebo
5 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
6 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
7 Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES) Recruiting NCT02836496 Phase 3 Mepolizumab 300 mg;Placebo matching mepolizumab;Active OCS capsules (5 mg prednisolone or prednisone);Placebo matching OCS capsules
8 Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921 Active, not recruiting NCT03298061 Phase 3 Mepolizumab;Prednisolone
9 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
10 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
11 Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
12 Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome Completed NCT00716651 Phase 2 mepolizumab
13 Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome Completed NCT00266565 Phase 1, Phase 2 Mepolizumab
14 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
15 Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT02947945 Phase 2 Reslizumab
16 Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT03010436 Phase 2 Benralizumab
17 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Not yet recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
18 Rituxan in Churg Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
19 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
20 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1 Cyclophosphamide;ATG (rabbit);G-CSF;Campath-1h;Fludarabine;Tacrolimus;Mesna
21 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
22 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
23 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
24 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Unknown status NCT01443000
25 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593 Not Applicable Infliximab;Rituximab
26 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
27 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
28 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
29 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
30 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
31 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
32 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
33 Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
34 Pediatric Vasculitis Initiative Recruiting NCT02006134
35 VCRC Tissue Repository Recruiting NCT02967068
36 Vasculitis Pregnancy Registry Recruiting NCT02593565
37 One-Time DNA Study for Vasculitis Recruiting NCT01241305
38 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
39 Soluble CD95 Ligand Role in the Pathophysiology of Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis Recruiting NCT03698071 Not Applicable
40 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045
41 NUCALA® Special Drug Use Investigation (EGPA, Long-term) Active, not recruiting NCT03557060 Nucala
42 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Active, not recruiting NCT01862068
43 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
44 Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome Terminated NCT02728271 Early Phase 1

Search NIH Clinical Center for Churg-Strauss Syndrome

Cochrane evidence based reviews: churg-strauss syndrome

Genetic Tests for Churg-Strauss Syndrome

Anatomical Context for Churg-Strauss Syndrome

MalaCards organs/tissues related to Churg-Strauss Syndrome:

41
Lung, Heart, Colon, T Cells, Kidney, Bone, Lymph Node

Publications for Churg-Strauss Syndrome

Articles related to Churg-Strauss Syndrome:

(show top 50) (show all 938)
# Title Authors Year
1
Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome. ( 29808153 )
2018
2
Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up. ( 29459042 )
2018
3
Massive Myocardial Necrosis due to Churg-Strauss Syndrome. ( 29884587 )
2018
4
Anaesthetic management and the role of sugammadex in a patient with Churg-Strauss syndrome. ( 29910505 )
2018
5
Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature. ( 29393242 )
2018
6
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease. ( 30057533 )
2018
7
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. ( 30134390 )
2018
8
Churg-Strauss Syndrome Presenting As Acute Necrotizing Eosinophilic Myocarditis. Concise review of the literature. ( 30179138 )
2018
9
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
10
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
11
Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome. ( 28255916 )
2017
12
Churg-strauss syndrome: a case report. ( 29203755 )
2017
13
Cutaneous manifestations of Churg-Strauss syndrome: key to diagnosis. ( 29267447 )
2017
14
Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28094120 )
2017
15
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis. ( 29269641 )
2017
16
Diagnosis of Churg-Strauss Syndrome Presented With Neuroendocrine Carcinoma: A Case Report. ( 28758089 )
2017
17
Sequential rituximab and omalizumab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28762062 )
2017
18
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 29170172 )
2017
19
Eye problems in a woman with Churg-Strauss syndrome. ( 28098669 )
2017
20
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. ( 29200781 )
2017
21
Heart involvement in Churg-Strauss syndrome. ( 28205199 )
2017
22
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
23
Rare Manifestation of Churg-Strauss Syndrome with Mediastinal Lymphadenopathies: Report of an Autopsy Case. ( 29249116 )
2017
24
Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes. ( 28337408 )
2017
25
Low Median Nerve Palsy as Initial Manifestation of Churg-Strauss Syndrome. ( 28089164 )
2017
26
Two different causes in a patient with distal symmetric axonal polyneuropathy: Churg-Strauss syndrome and multiple myeloma, coincidental or associated with each other? ( 28332041 )
2017
27
A Case of Churg-Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis) of the Urinary Bladder. ( 28477943 )
2017
28
Ventricular tachycardia as the first manifestation of Churg-Strauss syndrome. ( 30546698 )
2017
29
Polyneuropathy with demyelinating changes in Churg-Strauss syndrome: an unusual association. ( 28025723 )
2016
30
Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 27191665 )
2016
31
A case report and literature review of Churg-Strauss syndrome presenting with myocarditis. ( 28002315 )
2016
32
A case of hemorrhagic cholecystitis associated with Churg-Strauss syndrome. ( 26853987 )
2016
33
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ( 27725542 )
2016
34
Native T1 Mapping Demonstrating Apical Thrombi in Eosinophilic Myocarditis Associated with Churg-Strauss Syndrome. ( 27826352 )
2016
35
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
36
Churg Strauss syndrome formes frustes: A case report. ( 27728665 )
2016
37
Churg-Strauss Syndrome: Singulair or Silicone (or both?). ( 27228637 )
2016
38
A patient with Churg-Strauss syndrome complicated with pulmonary hemoptysis. ( 27041254 )
2016
39
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis. ( 26767873 )
2016
40
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
41
Not All Coughs Are Asthma or Allergies: Churg-Strauss Syndrome. ( 27431867 )
2016
42
Erratum to: Bowel perforations in a patient affected by Churg-Strauss syndrome under high-dose steroid treatment: will alternative drugs reduce risk of surgery? ( 26740233 )
2016
43
Churg-Strauss syndrome with endocardial injury, clot formation in heart's chambers, and neurological complications. ( 27910080 )
2016
44
Churg-Strauss syndrome with asymptomatic pulmonary emboli. ( 25751349 )
2015
45
Churg-Strauss Syndrome as an Unusual Cause of Dysphagia: Case Report. ( 26161355 )
2015
46
Churg-Strauss syndrome from an orthopaedic perspective. ( 26634374 )
2015
47
Small bowel involvement documented by capsule endoscopy in Churg-Strauss syndrome. ( 26664542 )
2015
48
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) presenting with polyneuropathy--a case series. ( 25695917 )
2015
49
Eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome): where are we now? ( 26521277 )
2015
50
Coronary involvement in Churg-Strauss syndrome. ( 26702692 )
2015

Variations for Churg-Strauss Syndrome

Expression for Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for Churg-Strauss Syndrome

Pathways related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CCL17 CCL26 IL10 IL5 TNF
2
Show member pathways
12.62 IL10 IL5 RNASE3 TNF
3
Show member pathways
12.08 CCL17 IL5 TNF
4
Show member pathways
11.94 CCL17 IL10 TNF
5
Show member pathways
11.81 CCL17 CCL26 IL10 IL5
6 11.62 IL10 IL5 MPO TNF
7 11.56 IL10 IL5 TNF
8 11.5 IL10 THBD TNF
9 11.31 CCL17 CCL26 IL10 TNF
10 11.26 HMGB1 MPO TNF
11 11.21 CCL17 IL10 IL5
12 11.07 IL5 TNF
13 11.06 CCL17 CCL26 IL10 IL5
14 11.02 HMGB1 MPO
15 10.96 IL10 IL5 TNF
16 10.95 IL10 IL5
17 10.73 CCL17 CCL26 IL10 IL5 TNF
18 10.71 MPO TNF
19 10.25 CCL17 CCL26 IL10 IL5 TNF

GO Terms for Churg-Strauss Syndrome

Cellular components related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL17 CCL26 HMGB1 IL10 IL5 MPO
2 cell surface GO:0009986 9.56 GHSR HMGB1 THBD TNF
3 azurophil granule lumen GO:0035578 9.33 MPO PRTN3 RNASE3
4 extracellular space GO:0005615 9.32 CCL17 CCL26 HMGB1 IL10 IL5 MPO

Biological processes related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.87 HMGB1 MPO PRTN3 RNASE3
2 cytokine-mediated signaling pathway GO:0019221 9.81 IL10 IL5 PRTN3 TNF
3 response to lipopolysaccharide GO:0032496 9.78 IL10 MPO THBD
4 cellular response to lipopolysaccharide GO:0071222 9.77 GHSR IL10 TNF
5 immune response GO:0006955 9.77 CCL17 CCL26 IL10 IL5 TNF
6 chemotaxis GO:0006935 9.75 CCL17 CCL26 HMGB1
7 defense response to bacterium GO:0042742 9.73 IL10 MPO RNASE3 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 IL10 IL5 TNF
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 CCL17 CCL26 HMGB1 TNF
10 negative regulation of interferon-gamma production GO:0032689 9.63 HMGB1 IL10
11 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TNF
12 response to glucocorticoid GO:0051384 9.63 HMGB1 IL10 TNF
13 positive regulation of cytokine secretion GO:0050715 9.62 IL10 TNF
14 regulation of synapse organization GO:0050807 9.62 IL10 TNF
15 negative regulation of myoblast differentiation GO:0045662 9.61 CCL17 TNF
16 positive regulation of vascular endothelial cell proliferation GO:1905564 9.6 GHSR HMGB1
17 response to food GO:0032094 9.58 GHSR MPO
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
19 positive regulation of podosome assembly GO:0071803 9.54 IL5 TNF
20 endothelial cell apoptotic process GO:0072577 9.52 IL10 TNF
21 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 IL10 TNF
22 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.48 GHSR IL10
23 positive regulation of sprouting angiogenesis GO:1903672 9.43 GHSR HMGB1 IL10
24 regulation of signaling receptor activity GO:0010469 9.43 CCL17 CCL26 HMGB1 IL10 IL5 TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.33 IL10 MPO TNF
26 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
27 inflammatory response GO:0006954 9.1 CCL17 CCL26 HMGB1 IL10 IL5 TNF

Molecular functions related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 HMGB1 RNASE3
2 cytokine activity GO:0005125 9.1 CCL17 CCL26 HMGB1 IL10 IL5 TNF
3 CCR chemokine receptor binding GO:0048020 8.96 CCL17 CCL26

Sources for Churg-Strauss Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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