MCID: CHR001
MIFTS: 50

Churg-Strauss Syndrome

Categories: Blood diseases, Cardiovascular diseases, Immune diseases

Aliases & Classifications for Churg-Strauss Syndrome

MalaCards integrated aliases for Churg-Strauss Syndrome:

Name: Churg-Strauss Syndrome 12 77 56 45 15 17 74
Allergic Granulomatosis Angiitis 12
Allergic Granulomatous Angiitis 12
Churg-Strauss Vasculitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3049
MeSH 45 D015267
NCIt 51 C34481
SNOMED-CT 69 82275008
ICD10 34 M30.1
UMLS 74 C0008728

Summaries for Churg-Strauss Syndrome

Disease Ontology : 12 A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has symptom asthma along with hay fever, rash and gastrointestinal bleeding.

MalaCards based summary : Churg-Strauss Syndrome, also known as allergic granulomatosis angiitis, is related to microscopic polyangiitis and granulomatosis with polyangiitis, and has symptoms including asthma An important gene associated with Churg-Strauss Syndrome is MPO (Myeloperoxidase), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Cyclophosphamide and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and colon.

Wikipedia : 77 Eosinophilic granulomatosis with polyangiitis (EGPA), also known as allergic granulomatosis, is an... more...

Related Diseases for Churg-Strauss Syndrome

Diseases related to Churg-Strauss Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 300)
# Related Disease Score Top Affiliating Genes
1 microscopic polyangiitis 31.4 MPO TNF
2 granulomatosis with polyangiitis 31.4 HMGB1 MPO PRTN3
3 granulomatous angiitis 31.2 IL5 PRTN3 THBD
4 hypereosinophilic syndrome 31.1 CCL17 IL5 RNASE3
5 chronic eosinophilic pneumonia 31.1 IL5 RNASE3
6 rapidly progressive glomerulonephritis 31.0 MPO PRTN3
7 vasculitis 31.0 MPO PRTN3 THBD TNF
8 eosinophilic pneumonia 30.9 CCL17 IL5 RNASE3
9 eosinophilic gastroenteritis 30.9 IL5 RNASE3
10 endomyocardial fibrosis 30.8 IL10 TNF
11 hypersensitivity vasculitis 30.6 MPO PRTN3
12 ige responsiveness, atopic 30.5 IL10 IL5 RNASE3
13 scleritis 30.4 IL5 TNF
14 pneumonia 30.2 IL10 IL5 MPO TNF
15 cellulitis 30.2 IL5 RNASE3 TNF
16 myocardial infarction 30.1 IL10 MPO THBD TNF
17 gastroenteritis 30.1 IL10 IL5 RNASE3 TNF
18 allergic bronchopulmonary aspergillosis 30.0 CCL17 IL5
19 otitis media 30.0 IL10 RNASE3 TNF
20 colitis 30.0 IL10 MPO TNF
21 asthma 30.0 CCL17 CCL26 IL10 IL5 MPO RNASE3
22 aspergillosis 29.8 CCL17 IL10 IL5 TNF
23 ulcerative colitis 29.7 IL10 MPO PRTN3 TNF
24 appendicitis 29.5 HMGB1 IL10 MPO TNF
25 rheumatoid arthritis 29.5 HMGB1 IL10 PRTN3 TNF
26 eosinophilic granulomatosis with polyangiitis 12.6
27 allergic angiitis 12.1
28 neuropathy 10.8
29 polyarteritis nodosa 10.8
30 myocarditis 10.7
31 glomerulonephritis 10.6
32 peripheral nervous system disease 10.6
33 polyneuropathy 10.6
34 branch retinal artery occlusion 10.6
35 cholecystitis 10.6
36 retinal artery occlusion 10.6
37 wells syndrome 10.6
38 central retinal artery occlusion 10.5
39 thrombosis 10.5
40 mononeuritis multiplex 10.5
41 ischemia 10.5
42 hepatitis 10.4
43 crescentic glomerulonephritis 10.4
44 optic nerve disease 10.4
45 maxillary sinusitis 10.4 MPO RNASE3
46 temporal arteritis 10.4
47 hemorrhage, intracerebral 10.4
48 dilated cardiomyopathy 10.4
49 hemopericardium 10.4
50 pericardial effusion 10.4

Graphical network of the top 20 diseases related to Churg-Strauss Syndrome:



Diseases related to Churg-Strauss Syndrome

Symptoms & Phenotypes for Churg-Strauss Syndrome

Symptoms:

12
  • asthma

Drugs & Therapeutics for Churg-Strauss Syndrome

Drugs for Churg-Strauss Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
2
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
3
leucovorin Approved Phase 4,Phase 2 58-05-9 143 6006
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Not Applicable 302-25-0
6
Methotrexate Approved Phase 4,Phase 2 1959-05-2, 59-05-2 126941
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Not Applicable 2921-57-5
8
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 50-24-8 5755
9
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 83-43-2 6741
10
Mycophenolic acid Approved Phase 4 24280-93-1 446541
11
rituximab Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 174722-31-7 10201696
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
13
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Not Applicable 2920-86-7
14 Antimetabolites Phase 4,Phase 3,Phase 2
15 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16 Antimetabolites, Antineoplastic Phase 4,Phase 3,Phase 2
17 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
19 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
21 Protective Agents Phase 4,Phase 3,Phase 1,Not Applicable
22 glucocorticoids Phase 4,Phase 3,Phase 2,Not Applicable
23 Autonomic Agents Phase 4,Phase 3,Not Applicable
24 Folate Phase 4,Phase 2
25 Vitamin B Complex Phase 4,Phase 2
26 Folic Acid Antagonists Phase 4,Phase 2
27 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Not Applicable
28 Prednisolone acetate Phase 4,Phase 3,Not Applicable
29 Hormones Phase 4,Phase 3,Phase 2,Not Applicable
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Not Applicable
31 Vitamin B9 Phase 4,Phase 2
32 Dermatologic Agents Phase 4,Phase 2,Not Applicable
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
34 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
35 Methylprednisolone Acetate Phase 4,Phase 3,Not Applicable
36 Anti-Infective Agents Phase 4,Not Applicable
37 Antiemetics Phase 4,Phase 3,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Hormone Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
40 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2
41 Neuroprotective Agents Phase 4,Phase 3,Not Applicable
42 Antibiotics, Antitubercular Phase 4
43 Antitubercular Agents Phase 4
44 Anti-Bacterial Agents Phase 4
45 Antineoplastic Agents, Immunological Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Immunoglobulins Phase 3,Phase 2,Phase 1,Not Applicable
47 Antibodies Phase 3,Phase 2,Phase 1,Not Applicable
48 Pharmaceutical Solutions Phase 3
49 Immunoglobulins, Intravenous Phase 3
50 Rho(D) Immune Globulin Phase 3

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
2 Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Completed NCT00307671 Phase 4 prednisone, methylprednisolone,cyclophosphamides;Cyclophosphamide, Azathioprine,prednisone,methylprednisolone;Mycophenolate mofetil,methotrexate
3 Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis. Recruiting NCT03164473 Phase 4 Rituximab;Azathioprine;Placebo-rituximab;Placebo-azathioprine
4 A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis Completed NCT02020889 Phase 3 Placebo
5 Association Corticosteroid/Azathioprine in Microscopic Polyangiitis/ Polyarteritis Nodosa or Eosinophilic Granulomatosis With Polyangiitis (Churg Strauss Syndrome) Completed NCT00647166 Phase 3 corticosteroid and azathioprine;corticosteroid and placebo
6 Rituximab in Eosinophilic Granulomatosis With Polyangiitis Recruiting NCT02807103 Phase 3 Rituximab;Placebo-rituximab;Cyclophosphamide;Placebo-cyclophosphamide
7 Long-term Access Program (LAP) of Mepolizumab for Subjects Who Participated in Study MEA115921 Active, not recruiting NCT03298061 Phase 3 Mepolizumab;Prednisolone
8 Efficacy and Safety Study of Mepolizumab in Subjects With Severe Hypereosinophilic Syndrome (HES) Active, not recruiting NCT02836496 Phase 3 Mepolizumab 300 mg;Placebo matching mepolizumab;Active OCS capsules (5 mg prednisolone or prednisone);Placebo matching OCS capsules
9 Intravenous Immunoglobulin After Relapse in Vasculitis Terminated NCT00307658 Phase 3 Intravenous immunoglobulins (human immunoglobulins G)
10 Cyclophosphamide Versus Methotrexate for Remission Maintenance in Systemic Necrotizing Vasculitides Unknown status NCT00751517 Phase 2 Methotrexate;Cyclophosphamide
11 Benralizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Unknown status NCT03010436 Phase 2 Benralizumab
12 Mepolizumab As a Steroid-sparing Treatment Option in the Churg Strauss Syndrome Completed NCT00527566 Phase 1, Phase 2
13 Safety and Efficacy Study of Mepolizumab in Churg Strauss Syndrome Completed NCT00716651 Phase 2 mepolizumab
14 Anti-Interleukin-5 (IL-5) Study for Hypereosinophilic Syndrome Completed NCT00266565 Phase 1, Phase 2 Mepolizumab
15 Steroids and Methotrexate to Treat Systemic Vasculitis Completed NCT00001256 Phase 2 prednisone and methotrexate
16 Reslizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis (EGPA) Study Recruiting NCT02947945 Phase 2 Reslizumab
17 Low Dose Naltrexone to Improve Physical Health in Patients With Vasculitis Recruiting NCT03482479 Phase 2 Naltrexone Hydrochloride
18 Rituxan in Churg Strauss Syndrome With Renal Involvement Terminated NCT00424749 Phase 2 Rituximab;Prednisone
19 Abatacept in ANCA Associated Vasculitis Terminated NCT00482066 Phase 2 Abatacept (Orencia)
20 Hematopoietic Stem Cell Support in Vasculitis Terminated NCT00278512 Phase 1 Cyclophosphamide;ATG (rabbit);G-CSF;Campath-1h;Fludarabine;Tacrolimus;Mesna
21 PRO Development for ANCA Associated Vasculitis Unknown status NCT01729624
22 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic Vasculitis Unknown status NCT01066208
23 Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases Unknown status NCT00006055 Not Applicable anti-thymocyte globulin;cyclophosphamide;cyclosporine;filgrastim;methylprednisolone;prednisone
24 RATTRAP: Infliximab Versus Rituximab in Systemic Necrotizing Vasculitides Completed NCT00307593 Not Applicable Infliximab;Rituximab
25 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
26 The ANCA Vasculitis Questionnaire (AAV-PRO©) Completed NCT02507024
27 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
28 Reproductive Health in Men and Women With Vasculitis Completed NCT02176070
29 Steroid-Induced Osteoporosis in the Pediatric Population - Canadian Incidence Study Completed NCT01663129
30 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
31 Survey of Patients With Idiopathic Orbital Inflammation Syndrome Completed NCT01443000
32 Eosinophilic Granulomatosis With Polyangiitis Cohort Recruiting NCT03036670
33 Determining Disease Activity Biomarkers in Individuals With Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) Recruiting NCT00315380
34 Pediatric Vasculitis Initiative Recruiting NCT02006134
35 VCRC Tissue Repository Recruiting NCT02967068
36 Vasculitis Pregnancy Registry Recruiting NCT02593565
37 One-Time DNA Study for Vasculitis Recruiting NCT01241305
38 Clinical Transcriptomics in Systemic Vasculitis (CUTIS) Recruiting NCT03004326
39 Soluble CD95 Ligand Role in the Pathophysiology of Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis Recruiting NCT03698071 Not Applicable
40 Observational Study of Characteristics, Treatment and Outcomes With Severe Asthma in the United States (CHRONICLE) Recruiting NCT03373045
41 NUCALA® Special Drug Use Investigation (EGPA, Long-term) Active, not recruiting NCT03557060 Nucala
42 Neutrophils as Prognostic Factors in Granulomatosis With Polyangiitis (Formerly Named Wegener's Granulomatosis) Active, not recruiting NCT01862068
43 VCRC Patient Contact Registry Patient-Reported Data Validation Study Enrolling by invitation NCT02190942
44 Immuno-ablation With Chemoimmunoradiation and Autologous Stem Cell Transplant for Churg-Strauss Syndrome Terminated NCT02728271 Early Phase 1

Search NIH Clinical Center for Churg-Strauss Syndrome

Cochrane evidence based reviews: churg-strauss syndrome

Genetic Tests for Churg-Strauss Syndrome

Anatomical Context for Churg-Strauss Syndrome

MalaCards organs/tissues related to Churg-Strauss Syndrome:

42
Lung, Heart, Colon, Neutrophil, Kidney, Liver, T Cells

Publications for Churg-Strauss Syndrome

Articles related to Churg-Strauss Syndrome:

(show top 50) (show all 945)
# Title Authors Year
1
Massive Myocardial Necrosis due to Churg-Strauss Syndrome. ( 29884587 )
2019
2
Ophthalmic Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Systematic Review of the Literature. ( 30134390 )
2019
3
Churg-Strauss Syndrome Presenting as Acute Necrotizing Eosinophilic Myocarditis: Concise Review of the Literature. ( 30179138 )
2019
4
Immunoglobulin G4-Related Disease Presenting with Clinical Similarity to Churg-Strauss Syndrome. ( 30772966 )
2019
5
Churg-strauss syndrome: clinical case and its feautures. ( 31055564 )
2019
6
Cardiogenic Shock: An Unusual Initial Presentation of Churg-Strauss Syndrome. ( 29808153 )
2018
7
Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome) Complicated by Perforation of the Small Intestine and Cholecystitis. ( 29269641 )
2018
8
Focus on the Involvement of the Nose and Paranasal Sinuses in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Nasal Cytology Reveals Infiltration of Eosinophils as a Very Common Feature. ( 29393242 )
2018
9
Churg-Strauss syndrome with cardiac involvement: case illustration and contribution of CMR in the diagnosis and clinical follow-up. ( 29459042 )
2018
10
Anaesthetic management and the role of sugammadex in a patient with Churg-Strauss syndrome. ( 29910505 )
2018
11
Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis: Exuberant Classic Clinical Picture of a Rare Disease. ( 30057533 )
2018
12
Coronary artery vasospasm in a patient withChurg-Strauss syndrome. ( 30366890 )
2018
13
Differential Diagnosis of Churg-Strauss Syndrome with Tingling Sensation and Weakness of the Lower Extremities. ( 30719419 )
2018
14
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) masquerading as acute ST-elevation myocardial infarction with complete resolution after immunosuppressive therapy: a case report. ( 31020153 )
2018
15
Eosinophilic Annular Erythema Associated with Churg-Strauss Syndrome. ( 29200781 )
2017
16
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
17
Polyneuropathy with demyelinating changes in Churg-Strauss syndrome: an unusual association. ( 28025723 )
2017
18
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
19
Clinical Characteristics and Treatment Response of Peripheral Neuropathy in the Presence of Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome): Experience at a Single Tertiary Center. ( 28079316 )
2017
20
Low Median Nerve Palsy as Initial Manifestation of Churg-Strauss Syndrome. ( 28089164 )
2017
21
Omalizumab-associated eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28094120 )
2017
22
Eye problems in a woman with Churg-Strauss syndrome. ( 28098669 )
2017
23
Heart involvement in Churg-Strauss syndrome. ( 28205199 )
2017
24
Hospital Morbidity Database for Epidemiological Studies on Churg-Strauss Syndrome. ( 28255916 )
2017
25
Two different causes in a patient with distal symmetric axonal polyneuropathy: Churg-Strauss syndrome and multiple myeloma, coincidental or associated with each other? ( 28332041 )
2017
26
Eosinophilic granulomatosis with polyangiitis (formerly known as Churg-Strauss syndrome) as a differential diagnosis of hypereosinophilic syndromes. ( 28337408 )
2017
27
A Case of Churg-Strauss Syndrome (Eosinophilic Granulomatosis With Polyangiitis) of the Urinary Bladder. ( 28477943 )
2017
28
Diagnosis of Churg-Strauss Syndrome Presented With Neuroendocrine Carcinoma: A Case Report. ( 28758089 )
2017
29
Sequential rituximab and omalizumab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 28762062 )
2017
30
Eosinophilic myocarditis as a first presentation of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 29170172 )
2017
31
Churg-strauss syndrome: a case report. ( 29203755 )
2017
32
Rare Manifestation of Churg-Strauss Syndrome with Mediastinal Lymphadenopathies: Report of an Autopsy Case. ( 29249116 )
2017
33
Cutaneous manifestations of Churg-Strauss syndrome: key to diagnosis. ( 29267447 )
2017
34
Ventricular tachycardia as the first manifestation of Churg-Strauss syndrome. ( 30546698 )
2017
35
Churg-Strauss syndrome that presented with mediastinal lymphadenopathy and calculous cholecystitis. ( 26767873 )
2016
36
Erratum to: Bowel perforations in a patient affected by Churg-Strauss syndrome under high-dose steroid treatment: will alternative drugs reduce risk of surgery? ( 26740233 )
2016
37
A patient with Churg-Strauss syndrome complicated with pulmonary hemoptysis. ( 27041254 )
2016
38
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
39
Optimal therapy and prospects for new medicines in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 27191665 )
2016
40
Churg-Strauss Syndrome: Singulair or Silicone (or both?). ( 27228637 )
2016
41
Churg-Strauss syndrome in a pediatric patient presenting with recurrent hemorrhagic stroke and mitral regurgitation due to a prolapsed mitral valve. ( 27381148 )
2016
42
Not All Coughs Are Asthma or Allergies: Churg-Strauss Syndrome. ( 27431867 )
2016
43
Echocardiographic Changes in Eosinophilic Endocarditis Induced by Churg-Strauss Syndrome. ( 27725542 )
2016
44
Native T1 Mapping Demonstrating Apical Thrombi in Eosinophilic Myocarditis Associated with Churg-Strauss Syndrome. ( 27826352 )
2016
45
Churg-Strauss syndrome with endocardial injury, clot formation in heart's chambers, and neurological complications. ( 27910080 )
2016
46
A case report and literature review of Churg-Strauss syndrome presenting with myocarditis. ( 28002315 )
2016
47
Usefulness of cardiac resonance imaging in Churg-Strauss syndrome. ( 25000251 )
2016
48
Letter to the editor: Colonic findings in a patient with relapse of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). ( 25795174 )
2016
49
[A case of hemorrhagic cholecystitis associated with Churg-Strauss syndrome]. ( 26853987 )
2016
50
Cardiac tamponade leading to the diagnosis of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a case report and review of the literature. ( 25070496 )
2015

Variations for Churg-Strauss Syndrome

Expression for Churg-Strauss Syndrome

Search GEO for disease gene expression data for Churg-Strauss Syndrome.

Pathways for Churg-Strauss Syndrome

Pathways related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 CCL17 CCL26 IL10 IL5 TNF
2
Show member pathways
12.62 IL10 IL5 RNASE3 TNF
3
Show member pathways
12.08 CCL17 IL5 TNF
4
Show member pathways
11.94 CCL17 IL10 TNF
5
Show member pathways
11.81 CCL17 CCL26 IL10 IL5
6 11.62 IL10 IL5 MPO TNF
7 11.56 IL10 IL5 TNF
8 11.5 IL10 THBD TNF
9 11.31 CCL17 CCL26 IL10 TNF
10 11.26 HMGB1 MPO TNF
11 11.21 CCL17 IL10 IL5
12 11.07 IL5 TNF
13 11.06 CCL17 CCL26 IL10 IL5
14 11.02 HMGB1 MPO
15 10.96 IL10 IL5 TNF
16 10.95 IL10 IL5
17 10.73 CCL17 CCL26 IL10 IL5 TNF
18 10.71 MPO TNF
19 10.25 CCL17 CCL26 IL10 IL5 TNF

GO Terms for Churg-Strauss Syndrome

Cellular components related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CCL17 CCL26 HMGB1 IL10 IL5 MPO
2 cell surface GO:0009986 9.56 GHSR HMGB1 THBD TNF
3 azurophil granule lumen GO:0035578 9.33 MPO PRTN3 RNASE3
4 extracellular space GO:0005615 9.32 CCL17 CCL26 HMGB1 IL10 IL5 MPO

Biological processes related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.87 HMGB1 MPO PRTN3 RNASE3
2 cytokine-mediated signaling pathway GO:0019221 9.81 IL10 IL5 PRTN3 TNF
3 response to lipopolysaccharide GO:0032496 9.78 IL10 MPO THBD
4 cellular response to lipopolysaccharide GO:0071222 9.77 GHSR IL10 TNF
5 immune response GO:0006955 9.77 CCL17 CCL26 IL10 IL5 TNF
6 chemotaxis GO:0006935 9.75 CCL17 CCL26 HMGB1
7 defense response to bacterium GO:0042742 9.73 IL10 MPO RNASE3 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.72 IL10 IL5 TNF
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 CCL17 CCL26 HMGB1 TNF
10 negative regulation of interferon-gamma production GO:0032689 9.63 HMGB1 IL10
11 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TNF
12 positive regulation of cytokine secretion GO:0050715 9.62 IL10 TNF
13 regulation of synapse organization GO:0050807 9.62 IL10 TNF
14 negative regulation of myoblast differentiation GO:0045662 9.61 CCL17 TNF
15 positive regulation of vascular endothelial cell proliferation GO:1905564 9.6 GHSR HMGB1
16 response to food GO:0032094 9.58 GHSR MPO
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
18 positive regulation of podosome assembly GO:0071803 9.54 IL5 TNF
19 endothelial cell apoptotic process GO:0072577 9.52 IL10 TNF
20 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 IL10 TNF
21 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.48 GHSR IL10
22 response to glucocorticoid GO:0051384 9.46 IL10 TNF
23 regulation of signaling receptor activity GO:0010469 9.43 CCL17 CCL26 HMGB1 IL10 IL5 TNF
24 negative regulation of growth of symbiont in host GO:0044130 9.33 IL10 MPO TNF
25 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
26 positive regulation of sprouting angiogenesis GO:1903672 9.26 GHSR IL10
27 inflammatory response GO:0006954 9.1 CCL17 CCL26 HMGB1 IL10 IL5 TNF

Molecular functions related to Churg-Strauss Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopolysaccharide binding GO:0001530 9.16 HMGB1 RNASE3
2 cytokine activity GO:0005125 9.1 CCL17 CCL26 HMGB1 IL10 IL5 TNF
3 CCR chemokine receptor binding GO:0048020 8.96 CCL17 CCL26

Sources for Churg-Strauss Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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