MCID: CCT001
MIFTS: 27

Cicatricial Ectropion

Categories: Eye diseases

Aliases & Classifications for Cicatricial Ectropion

MalaCards integrated aliases for Cicatricial Ectropion:

Name: Cicatricial Ectropion 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12782
ICD9CM 36 374.14
SNOMED-CT 69 28914006
UMLS 74 C0155196

Summaries for Cicatricial Ectropion

MalaCards based summary : Cicatricial Ectropion is related to ectropion and ichthyosis. An important gene associated with Cicatricial Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways is Keratinization. The drugs Fluorouracil and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin and eye, and related phenotype is integument.

Related Diseases for Cicatricial Ectropion

Diseases related to Cicatricial Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 ectropion 11.0
2 ichthyosis 10.5
3 autosomal recessive congenital ichthyosis 10.4
4 pyoderma 10.3
5 herpes zoster 10.3
6 pyoderma gangrenosum 10.3
7 pityriasis rubra pilaris 10.2
8 anthrax disease 10.2
9 herpes zoster ophthalmicus 10.2
10 colorectal cancer 10.1
11 kindler syndrome 10.1
12 porphyria cutanea tarda 10.1
13 ichthyosis, congenital, autosomal recessive 4b 10.1
14 dihydropyrimidine dehydrogenase deficiency 10.1
15 psoriatic arthritis 10.1
16 graft-versus-host disease 10.1
17 arthritis 10.1
18 ichthyosis lamellar 1 10.1
19 osteonecrosis 10.1
20 blastomycosis 10.1
21 lagophthalmos 10.1
22 lobomycosis 10.1
23 porphyria 10.1
24 chromoblastomycosis 10.1
25 dermoid cyst 10.1
26 cellulitis 10.1
27 cutaneous anthrax 10.1
28 chickenpox 10.1
29 monilethrix 9.8 DSG4 TGM1
30 skin disease 9.7 DSG4 TGM1

Graphical network of the top 20 diseases related to Cicatricial Ectropion:



Diseases related to Cicatricial Ectropion

Symptoms & Phenotypes for Cicatricial Ectropion

MGI Mouse Phenotypes related to Cicatricial Ectropion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.92 CBSL DSG4 TGM1 UROS

Drugs & Therapeutics for Cicatricial Ectropion

Drugs for Cicatricial Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Immunologic Factors Phase 2
3 Antimetabolites, Antineoplastic Phase 2
4 Immunosuppressive Agents Phase 2
5 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Terminated NCT02705352 Phase 2 5-Fluorouracil

Search NIH Clinical Center for Cicatricial Ectropion

Genetic Tests for Cicatricial Ectropion

Anatomical Context for Cicatricial Ectropion

MalaCards organs/tissues related to Cicatricial Ectropion:

42
Skin, Eye

Publications for Cicatricial Ectropion

Articles related to Cicatricial Ectropion:

(show top 50) (show all 88)
# Title Authors Year
1
Correction of cicatricial ectropion using non-ablative fractional laser resurfacing. ( 30056585 )
2019
2
Efficacy of lateral eyelid-block excision with canthoplasty and full-thickness skin grafting in lower eyelid cicatricial ectropion. ( 30390376 )
2019
3
Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. ( 30614837 )
2019
4
Frontosphenoidal Intraosseous Dermoid Cyst Presenting With Cicatricial Ectropion With Discharging Sinus. ( 30908467 )
2019
5
Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. ( 31106645 )
2019
6
Commentary on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. ( 31107691 )
2019
7
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. ( 28658179 )
2018
8
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. ( 28746254 )
2018
9
Reversible cicatricial ectropion associated with EGFR inhibitors. ( 29336655 )
2018
10
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. ( 29346172 )
2018
11
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. ( 29920894 )
2018
12
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. ( 27893584 )
2017
13
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. ( 28314226 )
2017
14
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. ( 28380102 )
2017
15
Cicatricial ectropion in a patient treated with dupilumab. ( 29260094 )
2017
16
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. ( 25794020 )
2016
17
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. ( 26674895 )
2016
18
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. ( 26859652 )
2016
19
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. ( 27191780 )
2016
20
Lipograft in cicatricial ectropion. ( 27842016 )
2016
21
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. ( 25569426 )
2015
22
Use of amniotic membrane graft in the surgical management of cicatricial ectropion associated with cetuximab therapy. ( 25576167 )
2015
23
Nonsurgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid. ( 25639983 )
2015
24
Cicatricial ectropion secondary to psoriatic arthritis. ( 25810938 )
2015
25
Superficial Temporal Artery Island Flap for Cicatricial Ectropion. ( 26079124 )
2015
26
Cicatricial ectropion in grzybowski type of multiple eruptive keratoacanthomas. ( 24481503 )
2014
27
Free transplantation of autogenous palmaris longus tendon in the repair of cicatricial ectropion of lower eyelid. ( 24693868 )
2014
28
Bisphosphonate-induced osteonecrosis of the maxilla presenting as a cicatricial ectropion. ( 24922331 )
2014
29
A simple method for the treatment of cicatricial ectropion and eyelid contraction in patients with periocular burn: vertical V-Y advancement of the eyelid. ( 25306087 )
2014
30
Management of cicatricial ectropion secondary to pyoderma gangrenosum. ( 24410585 )
2014
31
Viability of full-thickness skin grafts used for correction of cicatricial ectropion of lower eyelid in previously irradiated field in the periocular region. ( 22287483 )
2013
32
Modified Kuhnt-Szymanowski surgical procedure for secondary cicatricial ectropion in a horse. ( 22958337 )
2013
33
Use of hyaluronic acid gel in the management of cicatricial ectropion: results and complications. ( 24063354 )
2013
34
A novel TGM1 splicing mutation in a collodion baby with cicatricial ectropion. ( 24314425 )
2013
35
Cicatricial ectropion: a complication of topical 5-fluorouracil. ( 21872544 )
2012
36
Demographic characteristics of patients requiring full-thickness skin grafts for cicatricial ectropion at Duke Eye Center from 2000 to 2010. ( 23138221 )
2012
37
A bilateral cicatricial ectropion and bilateral upper lid shortening caused by 5-fluorouracil toxicity in a patient with dihydropyrimidine dehydrogenase deficiency. ( 21077799 )
2011
38
Mucous membrane graft for cicatricial ectropion in lamellar ichthyosis: an approach revisited. ( 21346670 )
2011
39
Maternal skin allograft for cicatricial ectropion in congenital icthyosis. ( 20090485 )
2010
40
Complications of Cicatricial Ectropion Repair with Pre-Auricular Wolfe Graft. ( 20337312 )
2010
41
Kindler syndrome causing severe cicatricial ectropion. ( 20592640 )
2010
42
The use of fibrin tissue glue in the repair of cicatricial ectropion of the lower eyelid. ( 20622696 )
2010
43
Cicatricial ectropion correction in a patient with pyoderma gangrenosum: case report. ( 19668972 )
2009
44
Repair of cicatricial ectropion in a harlequin baby. ( 19683196 )
2009
45
Reversible cicatricial ectropion precipitated by topical brimonidine eye drops. ( 18209648 )
2008
46
Correction of cicatricial ectropion by autologous fat graft. ( 18293030 )
2008
47
Nonsurgical treatment of cicatricial ectropion with hyaluronic acid filler. ( 18317150 )
2008
48
Cicatricial ectropion associated with treatment of metastatic colorectal cancer with cetuximab. ( 17237696 )
2007
49
Resolution of pityriasis rubra pilaris-induced cicatricial ectropion with systemic low-dose methotrexate. ( 17386290 )
2007
50
Periocular cutaneous toxicity and cicatricial ectropion: a potential class effect of antineoplastic agents that inhibit EGFR signaling. ( 18030130 )
2007

Variations for Cicatricial Ectropion

Expression for Cicatricial Ectropion

Search GEO for disease gene expression data for Cicatricial Ectropion.

Pathways for Cicatricial Ectropion

Pathways related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 DSG4 TGM1

GO Terms for Cicatricial Ectropion

Cellular components related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 DSG4 TGM1

Biological processes related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.16 DSG4 TGM1
2 cornification GO:0070268 8.96 DSG4 TGM1
3 keratinocyte differentiation GO:0030216 8.62 DSG4 TGM1

Molecular functions related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 CBSL UROS

Sources for Cicatricial Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....