MCID: CCT001
MIFTS: 25

Cicatricial Ectropion

Categories: Skin diseases

Aliases & Classifications for Cicatricial Ectropion

MalaCards integrated aliases for Cicatricial Ectropion:

Name: Cicatricial Ectropion 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12782
ICD9CM 34 374.14
SNOMED-CT 67 28914006
UMLS 71 C0155196

Summaries for Cicatricial Ectropion

MalaCards based summary : Cicatricial Ectropion is related to ectropion and lagophthalmos. An important gene associated with Cicatricial Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways is Porphyrin and chlorophyll metabolism. The drugs Fluorouracil and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and t cells.

Related Diseases for Cicatricial Ectropion

Diseases related to Cicatricial Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 ectropion 31.2 TGM1 LAX1 DCXR
2 lagophthalmos 30.8 LAX1 DCXR
3 porphyria 29.9 UROS UROD
4 porphyria cutanea tarda 29.4 UROS UROD
5 senile ectropion 29.2 SRCIN1 LAX1 DCXR
6 entropion 29.2 SRCIN1 LAX1 DCXR
7 ichthyosis 10.6
8 keratopathy 10.5
9 autosomal recessive congenital ichthyosis 10.5
10 skin disease 10.4
11 pyoderma 10.3
12 herpes zoster 10.3
13 pyoderma gangrenosum 10.3
14 keratitis, hereditary 10.2
15 pityriasis rubra pilaris 10.2
16 ichthyosis, congenital, autosomal recessive 4b 10.2
17 conjunctivitis 10.2
18 anthrax disease 10.2
19 exposure keratitis 10.2
20 herpes zoster ophthalmicus 10.2
21 colorectal cancer 10.1
22 epicanthus 10.1
23 ichthyosis vulgaris 10.1
24 kindler syndrome 10.1
25 trichomegaly 10.1
26 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
27 myeloma, multiple 10.1
28 dihydropyrimidine dehydrogenase deficiency 10.1
29 dermatitis, atopic 10.1
30 psoriatic arthritis 10.1
31 graft-versus-host disease 10.1
32 hereditary lymphedema i 10.1
33 benign teratoma 10.1
34 corneal disease 10.1
35 osteonecrosis 10.1
36 osteomyelitis 10.1
37 respiratory failure 10.1
38 orbital cellulitis 10.1
39 blastomycosis 10.1
40 lobomycosis 10.1
41 chromoblastomycosis 10.1
42 cystic teratoma 10.1
43 contact dermatitis 10.1
44 allergic contact dermatitis 10.1
45 keratoacanthoma 10.1
46 skin carcinoma 10.1
47 cellulitis 10.1
48 mature teratoma 10.1
49 adenoma 10.1
50 cutaneous anthrax 10.1

Graphical network of the top 20 diseases related to Cicatricial Ectropion:



Diseases related to Cicatricial Ectropion

Symptoms & Phenotypes for Cicatricial Ectropion

Drugs & Therapeutics for Cicatricial Ectropion

Drugs for Cicatricial Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Immunologic Factors Phase 2
3 Immunosuppressive Agents Phase 2
4 Antimetabolites Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-blinded Comparison of the Use of 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts. Completed NCT02705352 Phase 2 5-Fluorouracil

Search NIH Clinical Center for Cicatricial Ectropion

Genetic Tests for Cicatricial Ectropion

Anatomical Context for Cicatricial Ectropion

MalaCards organs/tissues related to Cicatricial Ectropion:

40
Skin, Eye, T Cells

Publications for Cicatricial Ectropion

Articles related to Cicatricial Ectropion:

(show top 50) (show all 207)
# Title Authors PMID Year
1
Treatment of periocular basal cell carcinoma with neoadjuvant vismodegib. 61
32490287 2020
2
The use of anterior segment optical coherence tomography in evaluation of punctal stenosis. 61
32245579 2020
3
Anterior lamellar deficit ectropion management. 61
32494043 2020
4
A Modified Hughes Flap for Correction of Refractory Cicatricial Lower Lid Retraction With Concomitant Ectropion. 61
32265375 2020
5
Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. 61
31106645 2020
6
Approach to treatment of cicatricial ectropion: a systematic review and meta-analysis comparing surgical and minimally invasive options. 61
31584117 2020
7
Cicatricial Ectropion Repair for Dermatologic Surgeons. 61
31517657 2020
8
Dupilumab-Induced Bilateral Cicatricial Ectropion in Real Life. 61
31732402 2020
9
Cicatricial ectropion after wound closure of facial laceration. 61
32015823 2020
10
Septo-capsulopalpebral fascial recession flap technique in lower blepharoplasty: An experience of 453 consecutive cases and a review of the literature. 61
31519503 2020
11
Non-surgical management of congenital ichthyosis using hyaluronic acid gel injection. 61
30354490 2020
12
Management of ocular manifestations of autosomal recessive congenital ichthyosis 4B, harlequin type, in the perinatal period. 61
31586585 2019
13
Multidisciplinary Treatment to Restore Vision in Ocular Burns. 61
31808803 2019
14
Case Report: Corneal Ulceration from Bilateral Ectropion Due to Congenital Ichthyosis. 61
31479026 2019
15
Comment on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 61
31397776 2019
16
Commentary on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 61
31107691 2019
17
Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 61
30614837 2019
18
Frontosphenoidal Intraosseous Dermoid Cyst Presenting With Cicatricial Ectropion With Discharging Sinus. 61
30908467 2019
19
Efficacy of lateral eyelid-block excision with canthoplasty and full-thickness skin grafting in lower eyelid cicatricial ectropion. 61
30390376 2019
20
Diseases, conditions, and drugs associated with cicatricial ectropion. 61
31116320 2019
21
Correction of cicatricial ectropion using non-ablative fractional laser resurfacing. 61
30056585 2019
22
Rare presentation occult lateral frontal rhinosinusitis with eyelid fistula, ectropion and lagophthalmos. A case report. 61
31501634 2019
23
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. 61
29920894 2018
24
Reversible cicatricial ectropion associated with EGFR inhibitors. 61
29336655 2018
25
Porous Polyethylene Implant Associated With Delayed Orbital Complications and Osteomyelitis After Orbital Reconstruction. 61
30192296 2018
26
Capecitabine-Induced Bilateral Ectropion: A Rare Ocular Manifestation Requiring Surgical Intervention. 61
30886481 2018
27
Case report of Wolfe grafting for the management of bilateral cicatricial eyelid ectropion following severe burn injuries. 61
30237879 2018
28
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. 61
28658179 2018
29
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. 61
29346172 2018
30
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. 61
28746254 2018
31
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. 61
27893584 2017
32
Ophthalmic manifestations in Rothmund-Thomson syndrome: Case report and review of literature. 61
29044077 2017
33
Cicatricial ectropion in a patient treated with dupilumab. 61
29260094 2017
34
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. 61
28815772 2017
35
Adult Orbital and Adnexal Xanthogranulomatous Disease. 61
28829109 2017
36
Use of Cyanoacrylate Glue Casting for Stabilization of Periocular Skin Grafts and Flaps. 61
27841829 2017
37
Recurrent Conjunctival Myofibrosarcoma Managed With Triple Application of Episcleral Brachytherapy. 61
28181930 2017
38
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. 61
29181406 2017
39
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. 61
28314226 2017
40
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. 61
28380102 2017
41
Management lacrimal sac abscesses using lacrimal probe and crawford silicon tube. 61
27903249 2016
42
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. 61
27191780 2016
43
Severe Oculofacial Sequelae of Cutaneous Blastomyces dermatitidis. 61
25098446 2016
44
Observations on Prostaglandin Orbitopathy. 61
25719374 2016
45
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. 61
26859652 2016
46
Lipograft in cicatricial ectropion. 61
27842016 2016
47
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. 61
25794020 2016
48
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. 61
26674895 2016
49
[Oculoplastics in Cameroon]. 61
26797886 2016
50
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. 61
26164158 2015

Variations for Cicatricial Ectropion

Expression for Cicatricial Ectropion

Search GEO for disease gene expression data for Cicatricial Ectropion.

Pathways for Cicatricial Ectropion

GO Terms for Cicatricial Ectropion

Biological processes related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme biosynthetic process GO:0006783 9.16 UROS UROD
2 porphyrin-containing compound biosynthetic process GO:0006779 8.96 UROS UROD
3 protoporphyrinogen IX biosynthetic process GO:0006782 8.62 UROS UROD

Molecular functions related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 UROS UROD

Sources for Cicatricial Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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