MCID: CCT001
MIFTS: 28

Cicatricial Ectropion

Categories: Eye diseases

Aliases & Classifications for Cicatricial Ectropion

MalaCards integrated aliases for Cicatricial Ectropion:

Name: Cicatricial Ectropion 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:12782
ICD9CM 35 374.14
SNOMED-CT 68 28914006
UMLS 72 C0155196

Summaries for Cicatricial Ectropion

MalaCards based summary : Cicatricial Ectropion is related to skin disease and ectropion. An important gene associated with Cicatricial Ectropion is TGM1 (Transglutaminase 1), and among its related pathways/superpathways is Keratinization. The drugs Fluorouracil and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Cicatricial Ectropion

Diseases related to Cicatricial Ectropion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 skin disease 29.9 TGM1 DSG4
2 ectropion 11.1
3 ichthyosis 10.6
4 lagophthalmos 10.5
5 autosomal recessive congenital ichthyosis 10.5
6 keratopathy 10.5
7 pyoderma 10.3
8 herpes zoster 10.3
9 pyoderma gangrenosum 10.3
10 keratitis, hereditary 10.2
11 pityriasis rubra pilaris 10.2
12 ichthyosis, congenital, autosomal recessive 4b 10.2
13 conjunctivitis 10.2
14 anthrax disease 10.2
15 exposure keratitis 10.2
16 herpes zoster ophthalmicus 10.2
17 colorectal cancer 10.1
18 epicanthus 10.1
19 ichthyosis vulgaris 10.1
20 kindler syndrome 10.1
21 porphyria cutanea tarda 10.1
22 trichomegaly 10.1
23 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
24 myeloma, multiple 10.1
25 dihydropyrimidine dehydrogenase deficiency 10.1
26 dermatitis, atopic 10.1
27 psoriatic arthritis 10.1
28 graft-versus-host disease 10.1
29 corneal disease 10.1
30 osteonecrosis 10.1
31 osteomyelitis 10.1
32 respiratory failure 10.1
33 orbital cellulitis 10.1
34 entropion 10.1
35 blastomycosis 10.1
36 lobomycosis 10.1
37 porphyria 10.1
38 senile ectropion 10.1
39 chromoblastomycosis 10.1
40 dermoid cyst 10.1
41 cystic teratoma 10.1
42 contact dermatitis 10.1
43 allergic contact dermatitis 10.1
44 keratoacanthoma 10.1
45 skin carcinoma 10.1
46 cellulitis 10.1
47 mature teratoma 10.1
48 adenoma 10.1
49 cutaneous anthrax 10.1
50 corneal ulcer 10.1

Graphical network of the top 20 diseases related to Cicatricial Ectropion:



Diseases related to Cicatricial Ectropion

Symptoms & Phenotypes for Cicatricial Ectropion

MGI Mouse Phenotypes related to Cicatricial Ectropion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.46 CBSL DSG4 LAX1 UROS
2 immune system MP:0005387 9.26 CBSL DSG4 LAX1 UROS
3 integument MP:0010771 8.92 CBSL DSG4 TGM1 UROS

Drugs & Therapeutics for Cicatricial Ectropion

Drugs for Cicatricial Ectropion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 2 51-21-8 3385
2 Immunosuppressive Agents Phase 2
3 Antimetabolites Phase 2
4 Immunologic Factors Phase 2
5 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Randomized, Double-blinded Comparison of the Use of 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts. Terminated NCT02705352 Phase 2 5-Fluorouracil

Search NIH Clinical Center for Cicatricial Ectropion

Genetic Tests for Cicatricial Ectropion

Anatomical Context for Cicatricial Ectropion

MalaCards organs/tissues related to Cicatricial Ectropion:

41
Skin, Eye, T Cells

Publications for Cicatricial Ectropion

Articles related to Cicatricial Ectropion:

(show top 50) (show all 194)
# Title Authors PMID Year
1
Comment on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 38
31397776 2019
2
Frontosphenoidal Intraosseous Dermoid Cyst Presenting With Cicatricial Ectropion With Discharging Sinus. 38
30908467 2019
3
Commentary on Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 38
31107691 2019
4
Simultaneous Lateral Tarsal Strip and Medial Spindle Procedures for Cicatricial Ectropion. 38
30614837 2019
5
Efficacy of lateral eyelid-block excision with canthoplasty and full-thickness skin grafting in lower eyelid cicatricial ectropion. 38
30390376 2019
6
Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. 38
31106645 2019
7
Diseases, conditions, and drugs associated with cicatricial ectropion. 38
31116320 2019
8
Correction of cicatricial ectropion using non-ablative fractional laser resurfacing. 38
30056585 2019
9
Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success. 38
29920894 2018
10
Capecitabine-Induced Bilateral Ectropion: A Rare Ocular Manifestation Requiring Surgical Intervention. 38
30886481 2018
11
Porous Polyethylene Implant Associated With Delayed Orbital Complications and Osteomyelitis After Orbital Reconstruction. 38
30192296 2018
12
Reversible cicatricial ectropion associated with EGFR inhibitors. 38
29336655 2018
13
Non-surgical management of congenital ichthyosis using hyaluronic acid gel injection. 38
30354490 2018
14
Case report of Wolfe grafting for the management of bilateral cicatricial eyelid ectropion following severe burn injuries. 38
30237879 2018
15
Apremilast Use in a Case of Cicatricial Ectropion Secondary to Severe Lamellar Ichthyosis. 38
29346172 2018
16
Ablative Fractional Laser Resurfacing With Laser-Assisted Delivery of 5-Fluorouracil for the Treatment of Cicatricial Ectropion and Periocular Scarring. 38
28658179 2018
17
Cicatricial Ectropion Secondary to Graft-Versus-Host Disease. 38
28746254 2018
18
Facial Pyoderma Gangrenosum Presenting With Cranial Nerve VII Palsy and Cicatricial Ectropion. 38
27893584 2017
19
Ophthalmic manifestations in Rothmund-Thomson syndrome: Case report and review of literature. 38
29044077 2017
20
Cicatricial ectropion in a patient treated with dupilumab. 38
29260094 2017
21
Adult Orbital and Adnexal Xanthogranulomatous Disease. 38
28829109 2017
22
Ectropion Improvement with Topical Tazarotene in Children with Lamellar Ichthyosis. 38
28815772 2017
23
Recurrent Conjunctival Myofibrosarcoma Managed With Triple Application of Episcleral Brachytherapy. 38
28181930 2017
24
Use of Cyanoacrylate Glue Casting for Stabilization of Periocular Skin Grafts and Flaps. 38
27841829 2017
25
Vertical-to-Horizontal Rotational Myocutaneous Flap for Repairing Cicatricial Lower Lid Ectropion: A Novel Surgical Technique. 38
29181406 2017
26
Long term follow up of mucous membrane grafting for cicatricial ectropion in Ichthyosis: A case report. 38
28314226 2017
27
Chromomycosis, an unusual cause of cicatricial ectropion: a case report. 38
28380102 2017
28
Management lacrimal sac abscesses using lacrimal probe and crawford silicon tube. 38
27903249 2016
29
Cicatricial Ectropion With Topical 5% Fluorouracil Cream. 38
27191780 2016
30
Severe Oculofacial Sequelae of Cutaneous Blastomyces dermatitidis. 38
25098446 2016
31
Observations on Prostaglandin Orbitopathy. 38
25719374 2016
32
"Boomerang Technique: " Simple Excision With Periosteal Suspension for Correction of Mild-to-Moderate Cicatricial Ectropion. 38
26859652 2016
33
Orbicularis Oculi Myocutaneous Flap for Upper Cicatricial Ectropion. 38
26674895 2016
34
Surgical Management of Cicatricial Ectropion in Pityriasis Rubra Pilaris. 38
25794020 2016
35
Lipograft in cicatricial ectropion. 38
27842016 2016
36
[Oculoplastics in Cameroon]. 38
26797886 2016
37
Full-Thickness Skin Graft as an Independent or Adjunctive Technique for Repair of Cicatricial Lower Eyelid Ectropion Secondary to Actinic Skin Changes. 38
26164158 2015
38
Nonsurgical treatment of congenital ichthyosis cicatricial ectropion and eyelid retraction using Restylane hyaluronic acid. 38
25639983 2015
39
Superficial Temporal Artery Island Flap for Cicatricial Ectropion. 38
26079124 2015
40
Frontal osteomyelitis presenting as upper eyelid ectropion: A cautionary tale. 38
26155088 2015
41
Periorbital necrotising fasciitis in infants: Presentation and management of six cases. 38
25786437 2015
42
Use of amniotic membrane graft in the surgical management of cicatricial ectropion associated with cetuximab therapy. 38
25576167 2015
43
Cicatricial ectropion secondary to psoriatic arthritis. 38
25810938 2015
44
The hybrid approach for reconstruction of severely destructed lower eyelids: combination of skin grafting, temporary tarsorrhaphy, and autologous fat grafting for cicatricial ectropion after injection of commercial grade silicone. 38
25569426 2015
45
A simple method for the treatment of cicatricial ectropion and eyelid contraction in patients with periocular burn: vertical V-Y advancement of the eyelid. 38
25306087 2014
46
Free transplantation of autogenous palmaris longus tendon in the repair of cicatricial ectropion of lower eyelid. 38
24693868 2014
47
Full thickness skin grafts in periocular reconstructions: long-term outcomes. 38
25105524 2014
48
Bisphosphonate-induced osteonecrosis of the maxilla presenting as a cicatricial ectropion. 38
24922331 2014
49
Spontaneous bilateral corneal perforation in a patient with ichthyosis. 38
24097116 2014
50
Management of cicatricial ectropion secondary to pyoderma gangrenosum. 38
24410585 2014

Variations for Cicatricial Ectropion

Expression for Cicatricial Ectropion

Search GEO for disease gene expression data for Cicatricial Ectropion.

Pathways for Cicatricial Ectropion

Pathways related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 TGM1 DSG4

GO Terms for Cicatricial Ectropion

Cellular components related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 TGM1 DSG4

Biological processes related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.16 TGM1 DSG4
2 cornification GO:0070268 8.96 TGM1 DSG4
3 keratinocyte differentiation GO:0030216 8.62 TGM1 DSG4

Molecular functions related to Cicatricial Ectropion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 UROS CBSL

Sources for Cicatricial Ectropion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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