MCID: CLR122
MIFTS: 24

Ciliary Body Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Ciliary Body Cancer

MalaCards integrated aliases for Ciliary Body Cancer:

Name: Ciliary Body Cancer 12 15
Malignant Tumor of the Ciliary Body 12
Malignant Neoplasm of Ciliary Body 12
Malignant Tumor of Ciliary Body 12
Tumor of the Ciliary Body 12
Neoplasm of Ciliary Body 12

Classifications:



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Disease Ontology 12 DOID:4352
NCIt 50 C4364 C4766
SNOMED-CT 67 126998003 93756008
ICD10 32 C69.4
UMLS 70 C0339349 C0496833

Summaries for Ciliary Body Cancer

MalaCards based summary : Ciliary Body Cancer, also known as malignant tumor of the ciliary body, is related to malignant ciliary body melanoma and ciliary body spindle cell melanoma. An important gene associated with Ciliary Body Cancer is PROX1 (Prospero Homeobox 1), and among its related pathways/superpathways are Angiogenesis (CST) and VEGF ligand-receptor interactions. Affiliated tissues include eye and brain, and related phenotype is cardiovascular system.

Related Diseases for Ciliary Body Cancer

Diseases related to Ciliary Body Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 malignant ciliary body melanoma 28.7 VEGFD TYR PROX1 LYVE1 FLT1
2 ciliary body spindle cell melanoma 11.1
3 acquired hemangioma 10.1 PROX1 LYVE1
4 intramuscular hemangioma 10.1 PROX1 LYVE1
5 capillary lymphangioma 10.1 PROX1 LYVE1
6 lymphangioma 10.1 PROX1 LYVE1
7 lymphangiosarcoma 10.1 PROX1 LYVE1
8 hypotrichosis-lymphedema-telangiectasia syndrome 10.1 PROX1 LYVE1
9 lymphedema-distichiasis syndrome 10.0 PROX1 LYVE1
10 hennekam syndrome 10.0 PROX1 LYVE1
11 myopia 10.0
12 leiomyoma 10.0
13 melanoma 10.0
14 cataract 10.0
15 malignant leptomeningeal tumor 10.0 TYR MLANA
16 meningeal melanoma 10.0 TYR MLANA
17 melanoacanthoma 10.0 TYR MLANA
18 halo nevi 10.0 TYR MLANA
19 sarcomatoid transitional cell carcinoma 10.0 TYR MLANA
20 spinal cord melanoma 10.0 TYR MLANA
21 melanomatosis 10.0 TYR MLANA
22 diffuse meningeal melanocytosis 10.0 TYR MLANA
23 epithelioid cell melanoma 10.0 TYR MLANA
24 orbit rhabdomyosarcoma 9.9 TYR MLANA
25 kidney angiomyolipoma 9.9 VEGFD MLANA
26 malignant spindle cell melanoma 9.9 TYR MLANA
27 nodular malignant melanoma 9.9 TYR MLANA
28 orofacial cleft 8 9.9 TYR MLANA
29 kidney benign neoplasm 9.9 VEGFD MLANA
30 amelanotic melanoma 9.9 TYR MLANA
31 angiokeratoma of fordyce 9.9 PROX1 FLT1
32 keratosis, seborrheic 9.9 TYR MLANA
33 melanoma in congenital melanocytic nevus 9.9 TYR MLANA
34 capillary disease 9.9 PROX1 FLT1
35 anal canal squamous cell carcinoma 9.9 VEGFD FLT1
36 chylothorax, congenital 9.9 VEGFD PROX1 LYVE1
37 lymphangitis 9.9 VEGFD PROX1 LYVE1
38 inflammatory breast carcinoma 9.9 VEGFD PROX1 LYVE1
39 clear cell sarcoma 9.9 TYR MLANA
40 skin benign neoplasm 9.8 TYR MLANA
41 neurofibroma 9.8 TYR MLANA
42 twin-to-twin transfusion syndrome 9.8 VEGFD FLT1
43 kuhnt-junius degeneration 9.8 VEGFD FLT1
44 neovascular glaucoma 9.8 VEGFD FLT1
45 vitiligo-associated multiple autoimmune disease susceptibility 1 9.8 TYR MLANA
46 lymphangioleiomyomatosis 9.8 VEGFD TYR
47 corneal neovascularization 9.8 LYVE1 FLT1
48 ocular albinism 9.8 TYR MLANA
49 vascular cancer 9.7 MLANA FLT1
50 angiomyolipoma 9.7 VEGFD TYR MLANA

Graphical network of the top 20 diseases related to Ciliary Body Cancer:



Diseases related to Ciliary Body Cancer

Symptoms & Phenotypes for Ciliary Body Cancer

MGI Mouse Phenotypes related to Ciliary Body Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.02 FLT1 LYVE1 PROX1 TYR VEGFD

Drugs & Therapeutics for Ciliary Body Cancer

Search Clinical Trials , NIH Clinical Center for Ciliary Body Cancer

Genetic Tests for Ciliary Body Cancer

Anatomical Context for Ciliary Body Cancer

MalaCards organs/tissues related to Ciliary Body Cancer:

40
Eye, Brain

Publications for Ciliary Body Cancer

Articles related to Ciliary Body Cancer:

(show all 16)
# Title Authors PMID Year
1
Possible role of standardized echography complementing ultrasound biomicroscopy in tumors of the anterior eye segment: a study in a series of 13 patients. 61
29774459 2018
2
A Rare Case of a Recurrent Giant Solitary Fibrous Tumor of the Ciliary Body of the Orbit. 61
27408474 2016
3
On the Classification and Grading of Medulloepithelioma of the Eye. 61
27239464 2016
4
[Metastasis of the ciliary body and iris from an oropharyngeal carcinoma]. 61
23817966 2014
5
[Mesectodermal leiomyoma. Unusual tumor of the ciliary body]. 61
25510793 2014
6
[Ultrasound biomicroscopy in iris lesions]. 61
10095358 1999
7
[Metastasis of differentiated follicular thyroid carcinoma to the ciliary body]. 61
7844948 1994
8
Clinical evaluation of primary peripheral cysts of the iris. 61
8201172 1994
9
[Mesectodermal leiomyoma of the ciliary body--clinical aspects, surgery and immunohistochemistry]. 61
2696714 1989
10
[Iridocyclosclerectomy for tumor of the ciliary body followed ultimately by cataract extraction and implantation of a lens]. 61
3652352 1987
11
[Displacement of the iris root: a frequent sign of the anterior spread of a tumor of the ciliary body]. 61
6630891 1983
12
Intraocular reticulum cell sarcoma: its dramatic response to systemic chemotherapy and its angiogenic potential. 61
326123 1977
13
A pigmented tumor of the ciliary body. 61
4604027 1974
14
["Adult type" malignant tumor of the ciliary body epithelium]. 61
4239674 1969
15
Congenital myopia associated with neuro-ectodermal tumor of the ciliary body and ocular dysgenesis mesodermalis. 61
14033491 1963
16
[A tumor of the ciliary body with cystic degeneration]. 61
13557529 1958

Variations for Ciliary Body Cancer

Expression for Ciliary Body Cancer

Search GEO for disease gene expression data for Ciliary Body Cancer.

Pathways for Ciliary Body Cancer

Pathways related to Ciliary Body Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.91 PROX1 FLT1
2
Show member pathways
9.83 VEGFD FLT1

GO Terms for Ciliary Body Cancer

Cellular components related to Ciliary Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.62 TYR MLANA

Biological processes related to Ciliary Body Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.43 VEGFD PROX1 FLT1
2 positive regulation of endothelial cell proliferation GO:0001938 9.16 VEGFD PROX1
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 8.96 VEGFD FLT1
4 vascular endothelial growth factor signaling pathway GO:0038084 8.62 VEGFD FLT1

Sources for Ciliary Body Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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