MCID: CRR012
MIFTS: 22

Cirrhotic Cardiomyopathy

Categories: Cardiovascular diseases, Liver diseases, Rare diseases

Aliases & Classifications for Cirrhotic Cardiomyopathy

MalaCards integrated aliases for Cirrhotic Cardiomyopathy:

Name: Cirrhotic Cardiomyopathy 58

Characteristics:

Orphanet epidemiological data:

58
cirrhotic cardiomyopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare hepatic diseases


External Ids:

ICD10 via Orphanet 33 I42.8
Orphanet 58 ORPHA57777

Summaries for Cirrhotic Cardiomyopathy

MalaCards based summary : Cirrhotic Cardiomyopathy is related to atrial standstill 1 and liver cirrhosis. An important gene associated with Cirrhotic Cardiomyopathy is ESM1 (Endothelial Cell Specific Molecule 1). The drugs Metoprolol and Anti-Arrhythmia Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and brain.

Related Diseases for Cirrhotic Cardiomyopathy

Graphical network of the top 20 diseases related to Cirrhotic Cardiomyopathy:



Diseases related to Cirrhotic Cardiomyopathy

Symptoms & Phenotypes for Cirrhotic Cardiomyopathy

Drugs & Therapeutics for Cirrhotic Cardiomyopathy

Drugs for Cirrhotic Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metoprolol Approved, Investigational Phase 3 37350-58-6, 51384-51-1 4171
2 Anti-Arrhythmia Agents Phase 3
3 Antihypertensive Agents Phase 3
4 Sympatholytics Phase 3
5 Adrenergic beta-1 Receptor Antagonists Phase 3
6
Dobutamine Approved 34368-04-2 36811
7
Carvedilol Approved, Investigational 72956-09-3 2585
8 Cardiotonic Agents
9 Adrenergic beta-Agonists
10 Adrenergic Agonists
11 Sympathomimetics
12 Protective Agents
13 Neurotransmitter Agents
14 Adrenergic Antagonists
15 Adrenergic beta-Antagonists
16 Adrenergic Agents
17 Liver Extracts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Metoprolol Succinate in Cardiac Remodeling Related to Nonalcoholic Cirrhosis. Randomized Study. Completed NCT01676285 Phase 3 Metoprolol succinate;placebo
2 Cardiac Dysfunction in Cirrhosis: Cirrhotic Cardiomyopathy Evaluated by Dobutamin MRI. Completed NCT00250315 Dobutamine
3 Efficacy of Carvedilol + Ivabradine vs Carvedilol Alone for Left Ventricular Diastolic Dysfunction in Chronic Liver Disease Patients and Its' Impact on Morbidity and Mortality; a Prospective Randomized Controlled Trial. Recruiting NCT04111133 Betablocker + ivabradine;Betablocker

Search NIH Clinical Center for Cirrhotic Cardiomyopathy

Genetic Tests for Cirrhotic Cardiomyopathy

Anatomical Context for Cirrhotic Cardiomyopathy

MalaCards organs/tissues related to Cirrhotic Cardiomyopathy:

40
Liver, Heart, Brain, Endothelial

Publications for Cirrhotic Cardiomyopathy

Articles related to Cirrhotic Cardiomyopathy:

(show top 50) (show all 305)
# Title Authors PMID Year
1
Evaluation of the effect of heat shock protein 70 targeted drugs on cirrhotic cardiomyopathy in biliary cirrhotic rats. 61
33652036 2021
2
Advances in cirrhotic cardiomyopathy. 61
33756518 2021
3
Prolonged QTc interval predicts long-term mortality in cirrhosis: a propensity score matching analysis. 61
33792461 2021
4
The prognostic value of P-wave dispersion and left atrial functions assessed with three-dimensional echocardiography in patients with cirrhosis. 61
33741802 2021
5
Effect of liver transplantation on QT-interval prolongation and impact on mortality. 61
33186663 2021
6
Reply To Letter To The Editor. 61
33711189 2021
7
Analogies and differences between cirrhotic cardiomyopathy and hepatopulmonary syndrome. 61
33174630 2021
8
Review article: comprehensive analysis of cirrhotic cardiomyopathy. 61
33689169 2021
9
The evaluation of cirrhotic cardiomyopathy in liver transplant candidates: an emerging debate. 61
33660905 2021
10
Cirrhotic Cardiomyopathy: An Evolving Diagnostic Entity with Long-Term Clinical Sequelae. 61
33683815 2021
11
Cirrhotic cardiomyopathy prevalence according to the new criteria. 61
33595171 2021
12
Cirrhotic Cardiomyopathy Predicts Post-Transplant Cardiovascular Disease: Revelations of The New Diagnostic Criteria. 61
33533556 2021
13
Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart. 61
33359222 2021
14
Cardiac evaluation of the kidney or liver transplant candidate. 61
33315765 2021
15
Overview of bile acid signaling in the cardiovascular system. 61
33521099 2021
16
Hepatocardiac or Cardiohepatic Interaction: From Traditional Chinese Medicine to Western Medicine. 61
33777158 2021
17
Cirrhotic Cardiomyopathy: The Interplay Between Liver and Cardiac Muscle. How Does the Cardiovascular System React When the Liver is Diseased? 61
31072296 2021
18
Relationship between QT interval prolongation and structural abnormalities in cirrhotic cardiomyopathy: A change in the current paradigm. 61
33453141 2021
19
Cirrhotic Cardiomyopathy in the Era of Liver Transplantation: Time for Precise Stepwise Evaluation. 61
33331343 2020
20
The prevalence of cirrhotic cardiomyopathy according to different diagnostic criteria. 61
33342074 2020
21
What Every Intensivist should Know about Impairment of Cardiac Function and Arrhythmias in Liver Disease Patients: A Review. 61
33446981 2020
22
Part 1: Disease of the Heart and Liver: A Relationship That Cuts Both Ways. 61
33337654 2020
23
Prognostic value of B-type natriuretic peptide in liver transplant patients: Implication in post-transplant mortality. 61
33249627 2020
24
Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy. 61
32654385 2020
25
Cirrhotic Cardiomyopathy - A Veiled Threat. 61
33229904 2020
26
Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels. 61
33220932 2020
27
Prevalence of cirrhotic cardiomyopathy and its relationship with serum pro-brain natriuretic peptide, hepatorenal syndrome, spontaneous bacterial peritonitis, and mortality. 61
33188455 2020
28
Myocardial Fibrosis and Inflammation in Liver Cirrhosis: MRI Study of the Liver-Heart Axis. 61
32808886 2020
29
Protective Effects of Spermidine Against Cirrhotic Cardiomyopathy in Bile Duct-Ligated Rats. 61
32902943 2020
30
Epigenetic-sensitive challenges of cardiohepatic interactions: clinical and therapeutic implications in heart failure patients. 61
32773512 2020
31
An Integrated Review of the Hepatorenal Syndrome. 61
32846202 2020
32
Preoperative Evaluation and Anesthetic Management of Patients With Liver Cirrhosis Undergoing Cardiac Surgery. 61
32891522 2020
33
Cirrhotic Cardiomyopathy. 61
32651721 2020
34
Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy. 61
32524673 2020
35
Diastolic dysfunction in patients with liver cirrhosis: A short-term, observational study at a Malaysian hospital. 61
32724001 2020
36
QTc prolongation in patients of cirrhosis and its relation with disease severity: An observational study from a rural teaching hospital. 61
32984166 2020
37
Left ventricular diastolic dysfunction in liver transplantation: a stronger association with non-alcoholic steatohepatitis. 61
32728634 2020
38
[Diagnosis and treatment of rare complications of liver cirrhosis]. 61
32536050 2020
39
Stress-Induced Takotsubo Cardiomyopathy After Transjugular Intrahepatic Portosystemic Shunt. 61
32607377 2020
40
Letter to the Editor: Diagnosis of Cirrhotic Cardiomyopathy: The Role of an Impaired Cardiac Reserve. 61
31709570 2020
41
Interplay of Liver-Heart Inflammatory Axis and Cannabinoid 2 Receptor Signaling in an Experimental Model of Hepatic Cardiomyopathy. 61
31469200 2020
42
Exercise Training Attenuates Cirrhotic Cardiomyopathy. 61
32246321 2020
43
Myocardial structural and functional changes in patients with liver cirrhosis awaiting liver transplantation: a comprehensive cardiovascular magnetic resonance and echocardiographic study. 61
32321533 2020
44
Autonomic and diastolic dysfunction association with quality of life impairment in cirrhotic patients. 61
32088164 2020
45
Cirrhotic cardiomyopathy. 61
32395813 2020
46
CRITERIA FOR DIAGNOSIS OF CARDIOMYOPATHY IN PATIENTS WITH ALCOHOLIC LIVER CIRRHOSIS BEFORE THE ONSET OF HEART DAMAGE CLINICAL SIGNS. 61
32383707 2020
47
Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy. 61
31961720 2020
48
Electrocardiographic Changes in Liver Cirrhosis-Clues for Cirrhotic Cardiomyopathy. 61
32050594 2020
49
Physiopathological and diagnostic aspects of cirrhotic cardiomyopathy. 61
32897266 2020
50
Physiopathological and diagnostic aspects of cirrhotic cardiomyopathy. 61
32459210 2020

Variations for Cirrhotic Cardiomyopathy

Expression for Cirrhotic Cardiomyopathy

Search GEO for disease gene expression data for Cirrhotic Cardiomyopathy.

Pathways for Cirrhotic Cardiomyopathy

GO Terms for Cirrhotic Cardiomyopathy

Sources for Cirrhotic Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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