MCID: CLS052
MIFTS: 25

Classic Hairy Cell Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Classic Hairy Cell Leukemia

MalaCards integrated aliases for Classic Hairy Cell Leukemia:

Name: Classic Hairy Cell Leukemia 60
Leukemic Reticuloendotheliosis 60
Hairy Cell Leukemia 74
Hcl-C 60

Characteristics:

Orphanet epidemiological data:

60
classic hairy cell leukemia
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe),1-9/1000000 (United States); Age of onset: Adult;

Classifications:



External Ids:

MESH via Orphanet 46 D007943
ICD10 via Orphanet 35 C91.4
UMLS via Orphanet 75 C0023443
Orphanet 60 ORPHA58017
UMLS 74 C0023443

Summaries for Classic Hairy Cell Leukemia

MalaCards based summary : Classic Hairy Cell Leukemia, also known as leukemic reticuloendotheliosis, is related to intrapelvic lymph node leukemic reticuloendotheliosis and reticuloendotheliosis. An important gene associated with Classic Hairy Cell Leukemia is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). Affiliated tissues include bone, lymph node and spleen.

Related Diseases for Classic Hairy Cell Leukemia

Diseases related to Classic Hairy Cell Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 intrapelvic lymph node leukemic reticuloendotheliosis 12.5
2 reticuloendotheliosis 11.0
3 lymphoma 10.3
4 leukemia 10.3
5 hairy cell leukemia 10.3
6 vasculitis 10.2
7 hepatitis 10.1
8 thrombocytopenia 10.1
9 gaucher's disease 10.1
10 sezary's disease 10.1
11 pancytopenia 10.0

Graphical network of the top 20 diseases related to Classic Hairy Cell Leukemia:



Diseases related to Classic Hairy Cell Leukemia

Symptoms & Phenotypes for Classic Hairy Cell Leukemia

Drugs & Therapeutics for Classic Hairy Cell Leukemia

Genetic Tests for Classic Hairy Cell Leukemia

Anatomical Context for Classic Hairy Cell Leukemia

MalaCards organs/tissues related to Classic Hairy Cell Leukemia:

42
Bone, Lymph Node, Spleen, Monocytes, Testes, Bone Marrow

Publications for Classic Hairy Cell Leukemia

Articles related to Classic Hairy Cell Leukemia:

(show top 50) (show all 80)
# Title Authors Year
1
Classic hairy cell leukemia complicated by pancytopenia and severe infection: a report of 3 cases treated with vemurafenib. ( 30630817 )
2019
2
Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia. ( 27903528 )
2017
3
Bouroncle BA, Wiseman BK, Doan CA. Leukemic reticuloendotheliosis. Blood. 1958;13(7):609-630. ( 27013208 )
2016
4
Cutaneous leukocytoclastic vasculitis complicating hairy cell leukemia (leukemic reticuloendotheliosis). ( 3740885 )
1986
5
Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis). ( 6692307 )
1984
6
Leukocytoclastic vasculitis in hairy cell leukemia (leukemic reticuloendotheliosis). ( 6651310 )
1983
7
Phenotype of the hairy cells of leukemic reticuloendotheliosis defined by monoclonal antibodies. ( 6340460 )
1983
8
Second malignancies in hairy cell leukemia (leukemic reticuloendotheliosis). ( 6291381 )
1982
9
A case of leukemic reticuloendotheliosis responding to oxymetholone. ( 7093884 )
1982
10
Comparison of the tartrate-resistant acid phosphatase in Gaucher's disease and leukemic reticuloendotheliosis. ( 6794944 )
1981
11
Infections in hairy cell leukemia (leukemic reticuloendotheliosis). ( 7226028 )
1981
12
Comparison of tartrate-resistant acid phosphatase in normal mouse tissues to that in the reticulum cells of leukemic reticuloendotheliosis. ( 7226020 )
1981
13
Beneficial effect of hepatitis in leukemic reticuloendotheliosis. ( 7247595 )
1981
14
Leukemic reticuloendotheliosis (hairy cell leukemia): a review of the evidence concerning the immunology and origin of the cell. ( 7015022 )
1980
15
Radiation exposure as a possible etiologic factor in hairy cell leukemia (leukemic reticuloendotheliosis). ( 7417955 )
1980
16
Leukemic reticuloendotheliosis (hairy cell leukemia). ( 367468 )
1979
17
Functional studies of hairy cell leukemia (leukemic reticuloendotheliosis). ( 433832 )
1979
18
Splenectomy as initial therapy in twenty-six patients with leukemic reticuloendotheliosis (hairy cell leukemia). ( 445435 )
1979
19
Hairy cell leukemia (leukemic reticuloendotheliosis): chemotherapy for splenectomy failures. ( 454837 )
1979
20
The effectiveness of rubidazone in hairy cell leukemia (leukemic reticuloendotheliosis). ( 454838 )
1979
21
Treatment of hairy cell leukemia (leukemic reticuloendotheliosis) II. Chlorambucil therapy in postsplenectomy patients with progressive disease. ( 454839 )
1979
22
Leukopheresis therapy of leukemic reticuloendotheliosis (hairy cell leukemia). ( 465739 )
1979
23
Malignant lymphoma simulating leukemic reticuloendotheliosis: a clinicopathologic study of ten cases. ( 367571 )
1979
24
Coexistence of leukemic reticuloendotheliosis and histiocytic lymphoma: a case report. ( 376100 )
1979
25
Massive lymphadenopathy mimicking lymphoma in leukemic reticuloendotheliosis. ( 420244 )
1979
26
Spontaneous rupture of spleen in leukemic reticuloendotheliosis. ( 426189 )
1979
27
Hairy cell leukemia (leukemic reticuloendotheliosis) in serous effusions. ( 78614 )
1978
28
Leukemic reticuloendotheliosis: polyclonal surface immunoglobulin on "hairy" cells. ( 417798 )
1978
29
Leukocyte mobilization in leukemic reticuloendotheliosis. ( 626463 )
1978
30
Structural and functional properties of the "hairy" cells of leukemic reticuloendotheliosis. ( 626930 )
1978
31
Leukemic reticuloendotheliosis: report of a case with peripheral blood remission on androgen therapy. ( 647635 )
1978
32
Leukemic reticuloendotheliosis. Loss of platelet defect after splenectomy. ( 660848 )
1978
33
Use of the bone marrow imprint in the diagnosis of leukemic reticuloendotheliosis ("hairy cell leukemia"). ( 70993 )
1977
34
Leukemic reticuloendotheliosis: "hairy cell leukemia," functional and structural features of the abnormal cell in a patient with profound leukocytosis. ( 139955 )
1977
35
Leukemic reticuloendotheliosis (hairy cell leukemia). ( 614367 )
1977
36
Biochemical characterization of the tartrate-resistant acid phosphatase of human spleen with leukemic reticuloendotheliosis as a pyrophosphatase. ( 12883 )
1977
37
Further ultrastructural characterization of hairy cells of leukemic reticuloendotheliosis. ( 831514 )
1977
38
Kinetic properties of tartrate-resistant acid phosphatase isolated from human spleen with leukemic reticuloendotheliosis. ( 863887 )
1977
39
Reassessment of a cytochemical test for differential diagnosis of leukemic reticuloendotheliosis. ( 879102 )
1977
40
The rate of membrane turnover by the hairy cells of leukemic reticuloendotheliosis: a kinetic study of a receptor for IgM. ( 894034 )
1977
41
Impaired marrow granulocyte reserve and leukocyte mobilization in leukemic reticuloendotheliosis. ( 907243 )
1977
42
The heterogeneity of leukemic reticuloendotheliosis, "hairy cell leukemia". Evidence for its monocytic origin. ( 1063052 )
1976
43
Hairy cell leukemia (leukemic reticuloendotheliosis) II. Ultrastructure of the spleen. ( 1260714 )
1976
44
Leukemic reticuloendotheliosis. A failure of monocyte production. ( 775335 )
1976
45
Surface immunoglobulins and receptor sites for aggregated IgG on leukemic reticuloendotheliosis cells. ( 942870 )
1976
46
Studies of intracellular distribution of acid phosphatase 5 in the spleen cells of leukemic reticuloendotheliosis by isopycnic gradient centrifugation. ( 954212 )
1976
47
Cells containing Langerhans cell granules in human lymph nodes of "atypical hyperplasia" with fatal outcome and leukemic reticuloendotheliosis. ( 961415 )
1976
48
Leukemic reticuloendotheliosis and "hairy cells". ( 967216 )
1976
49
Leukemic reticuloendotheliosis: a medical technologist's diagnosis. ( 984076 )
1976
50
Editorial: Leukemic reticuloendotheliosis: a defined syndrome of an ill defined cell. ( 1063913 )
1976

Variations for Classic Hairy Cell Leukemia

Expression for Classic Hairy Cell Leukemia

Search GEO for disease gene expression data for Classic Hairy Cell Leukemia.

Pathways for Classic Hairy Cell Leukemia

GO Terms for Classic Hairy Cell Leukemia

Sources for Classic Hairy Cell Leukemia

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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37 IUPHAR
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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