MCID: CLS047
MIFTS: 28

Classic Progressive Supranuclear Palsy Syndrome

Categories: Neuronal diseases, Eye diseases, Rare diseases

Aliases & Classifications for Classic Progressive Supranuclear Palsy Syndrome

MalaCards integrated aliases for Classic Progressive Supranuclear Palsy Syndrome:

Name: Classic Progressive Supranuclear Palsy Syndrome 59
Steele-Richardson-Olszewski Disease 59
Progressive Supranuclear Palsy 73
Classic Psp Syndrome 59
Richardson Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
classic progressive supranuclear palsy syndrome
Inheritance: Not applicable; Age of onset: Adult; Age of death: elderly;

Classifications:



External Ids:

Orphanet 59 ORPHA240071
UMLS via Orphanet 74 C0038868
ICD10 via Orphanet 34 G23.1

Summaries for Classic Progressive Supranuclear Palsy Syndrome

MalaCards based summary : Classic Progressive Supranuclear Palsy Syndrome, also known as steele-richardson-olszewski disease, is related to feigenbaum bergeron richardson syndrome and atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease, and has symptoms including back pain, headache and muscle rigidity. An important gene associated with Classic Progressive Supranuclear Palsy Syndrome is MAPT (Microtubule Associated Protein Tau). Affiliated tissues include brain, eye and cortex.

Related Diseases for Classic Progressive Supranuclear Palsy Syndrome

Diseases related to Classic Progressive Supranuclear Palsy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 feigenbaum bergeron richardson syndrome 12.0
2 atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease 11.0
3 leopard syndrome 10.9
4 supranuclear palsy, progressive, 1 9.9
5 multiple system atrophy 1 9.8
6 parkinson disease, late-onset 9.8
7 cerebritis 9.8
8 corticobasal degeneration 9.8

Graphical network of the top 20 diseases related to Classic Progressive Supranuclear Palsy Syndrome:



Diseases related to Classic Progressive Supranuclear Palsy Syndrome

Symptoms & Phenotypes for Classic Progressive Supranuclear Palsy Syndrome

UMLS symptoms related to Classic Progressive Supranuclear Palsy Syndrome:


back pain, headache, muscle rigidity, ophthalmoplegia, pain, sciatica, seizures, syncope, tremor, photophobia, chronic pain, bradykinesia, poor mobility, vertigo/dizziness, forgetful, sleeplessness

Drugs & Therapeutics for Classic Progressive Supranuclear Palsy Syndrome

Search Clinical Trials , NIH Clinical Center for Classic Progressive Supranuclear Palsy Syndrome

Genetic Tests for Classic Progressive Supranuclear Palsy Syndrome

Anatomical Context for Classic Progressive Supranuclear Palsy Syndrome

MalaCards organs/tissues related to Classic Progressive Supranuclear Palsy Syndrome:

41
Brain, Eye, Cortex, Thalamus, Pons, Cerebellum, Spinal Cord

Publications for Classic Progressive Supranuclear Palsy Syndrome

Articles related to Classic Progressive Supranuclear Palsy Syndrome:

(show top 50) (show all 807)
# Title Authors Year
1
Traumatic Brain Injury and Firearm Use and Risk of Progressive Supranuclear Palsy Among Veterans. ( 29973911 )
2018
2
Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging? ( 29973914 )
2018
3
Neurogenic bladder in progressive supranuclear palsy: A comparison with Parkinson's disease and multiple system atrophy. ( 29356135 )
2018
4
Aphasia in Progressive Supranuclear Palsy: As Severe as Progressive Non-Fluent Aphasia. ( 29254097 )
2018
5
Anti-inflammatory drug use and progressive supranuclear palsy. ( 29307562 )
2018
6
DCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy. ( 29499916 )
2018
7
Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype. ( 29926172 )
2018
8
Specificity and sensitivity of magnetic resonance imaging findings in the diagnosis of progressive supranuclear palsy. ( 28432758 )
2018
9
Association between semantic dementia and progressive supranuclear palsy. ( 29661923 )
2018
10
Palliative care and its emerging role in Multiple System Atrophy and Progressive Supranuclear Palsy. ( 28341224 )
2017
11
Neck Vibration Proprioceptive Postural Response Intact in Progressive Supranuclear Palsy unlike Idiopathic Parkinson's Disease. ( 29326649 )
2017
12
Clinical Profile of Dysphagia in Patients with Parkinson's Disease, Progressive Supranuclear Palsy and Multiple System Atrophy. ( 28799303 )
2017
13
Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry. ( 28706282 )
2017
14
Increased basal ganglia binding of<sup>18</sup>F-AV-1451 in patients with progressive supranuclear palsy. ( 27709757 )
2017
15
Distinct patterns of imprecise consonant articulation among Parkinson's disease, progressive supranuclear palsy and multiple system atrophy. ( 27894006 )
2017
16
Abnormal Resting-State Functional Connectivity in Progressive Supranuclear Palsy and Corticobasal Syndrome. ( 28634465 )
2017
17
La belle indiffAcrence revisited: a case report on progressive supranuclear palsy misdiagnosed as conversion disorder. ( 28814874 )
2017
18
The Neuropsychology (Broadly Conceived) of Multiple System Atrophy, Progressive Supranuclear Palsy, and Corticobasal Degeneration. ( 28961692 )
2017
19
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. ( 28271184 )
2017
20
Which ante mortem clinical features predict progressive supranuclear palsy pathology? ( 28500752 )
2017
21
Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study. ( 27310132 )
2016
22
Loss of substantia nigra hyperintensity on 7 Tesla MRI of Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. ( 26951846 )
2016
23
Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. ( 27111692 )
2016
24
DCTN1 p.K56R in progressive supranuclear palsy. ( 27132499 )
2016
25
Obsessive compulsive personality disorder and Progressive Supranuclear Palsy. ( 27688199 )
2016
26
Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. ( 27115769 )
2016
27
Finding a new therapeutic approach for no-option Parkinsonisms: mesenchymal stromal cells for progressive supranuclear palsy. ( 27160012 )
2016
28
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal Degeneration. ( 26818518 )
2016
29
Study of LRRK2 variation in tauopathy: Progressive supranuclear palsy and corticobasal degeneration. ( 27709685 )
2016
30
Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) performance in progressive supranuclear palsy and multiple system atrophy. ( 27334897 )
2016
31
An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability. ( 27842578 )
2016
32
MRI gray and white matter measures in progressive supranuclear palsy and corticobasal syndrome. ( 27411806 )
2016
33
Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options. ( 27526039 )
2016
34
Progressive supranuclear palsy and corticobasal degeneration: Diagnostic challenges and clinicopathological considerations. ( 27561438 )
2016
35
Plasma Screening for Progranulin Mutations in Patients with Progressive Supranuclear Palsy and Corticobasal Syndromes. ( 27163816 )
2016
36
Idiopathic Basal Ganglia Calcification Presented with Progressive Supranuclear Palsy-like Features. ( 26879023 )
2016
37
Tau pathology in aged cynomolgus monkeys is progressive supranuclear palsy/corticobasal degeneration- but not Alzheimer disease-like -Ultrastructural mapping of tau by EDX. ( 27842611 )
2016
38
Different decision deficits impair response inhibition in progressive supranuclear palsy and Parkinson's disease. ( 26582559 )
2016
39
The MAPT gene is differentially methylated in the progressive supranuclear palsy brain. ( 27709663 )
2016
40
Progressive supranuclear palsy motor phenotype in a patient with pineocytoma. ( 27432179 )
2016
41
Unusual phenotype of pathologically confirmed progressive supranuclear palsy with autonomic dysfunction and cerebellar ataxia: Case report. ( 27861346 )
2016
42
Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy. ( 26936765 )
2016
43
Obsessive compulsive personality disorder in Progressive Supranuclear Palsy, Multiple System Atrophy and Essential Tremor. ( 27364040 )
2016
44
Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. ( 26854325 )
2016
45
Whole-Brain Atrophy Rate in Idiopathic Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy. ( 27190673 )
2016
46
Clinical and imaging findings of progressive supranuclear palsy with predominant cerebellar ataxia. ( 27030358 )
2016
47
microRNA profiling: increased expression of miR-147a and miR-518e in progressive supranuclear palsy (PSP). ( 27052995 )
2016
48
Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy. ( 27697694 )
2016
49
Progressive Supranuclear Palsy: What Do We Know About it? ( 25732053 )
2015
50
Utility of Frontal Assessment Battery in detection of neuropsychological dysfunction in Richardson variant of progressive supranuclear palsy. ( 25666771 )
2015

Variations for Classic Progressive Supranuclear Palsy Syndrome

Expression for Classic Progressive Supranuclear Palsy Syndrome

Search GEO for disease gene expression data for Classic Progressive Supranuclear Palsy Syndrome.

Pathways for Classic Progressive Supranuclear Palsy Syndrome

GO Terms for Classic Progressive Supranuclear Palsy Syndrome

Sources for Classic Progressive Supranuclear Palsy Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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