MCID: CLR001
MIFTS: 40

Clear Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 45 74
Acanthoma, Clear Cell 74
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 45 D049309
NCIt 51 C97041
SNOMED-CT 69 65540008

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to acanthoma and pilar sheath acanthoma. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include skin and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and hematopoietic system

Wikipedia : 77 Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 acanthoma 32.2 FGF10 FGFR2
2 pilar sheath acanthoma 12.5
3 epidermolytic acanthoma 12.5
4 large cell acanthoma 12.5
5 acantholytic acanthoma 12.2
6 onychocytic matricoma 11.2
7 familial progressive hyperpigmentation 10.3 FGF7 KITLG
8 psoriasis 10.3
9 apert syndrome 10.3 FGF10 FGF7 FGFR2
10 muenke syndrome 10.3 FGF10 FGF7 FGFR2
11 lacrimoauriculodentodigital syndrome 10.3 FGF10 FGF7 FGFR2
12 pfeiffer syndrome 10.3 FGF10 FGF7 FGFR2
13 nevus, epidermal 10.2
14 ichthyosis 10.2
15 nodular hidradenoma 10.2 CEACAM5 KITLG
16 clear cell adenoma 10.2 CEACAM5 KITLG
17 predominantly cortical thymoma 10.1 IVL PDPN
18 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 PDPN
19 muir-torre syndrome 10.1
20 epidermodysplasia verruciformis 1 10.1
21 melanoma 10.1
22 psoriasis 7 10.1
23 psoriasis 11 10.1
24 psoriasis 13 10.1
25 autosomal recessive congenital ichthyosis 10.1
26 keratosis 10.1
27 squamous cell carcinoma 10.1
28 keratoacanthoma 10.1
29 cowden syndrome 10.1
30 in situ carcinoma 10.1
31 bowen's disease 10.1
32 multifocal motor neuropathy 10.0 CD1A CD1E
33 rheumatic disease 10.0 FLG IFNA1 IL2RA
34 adult xanthogranuloma 10.0 CD68 HAVCR1
35 eccrine adenocarcinoma 10.0 CD1C CEACAM5
36 fox-fordyce disease 9.9 CD68 CEACAM5
37 thymus lipoma 9.9 CD1A CD1B CD1C
38 immune system organ benign neoplasm 9.9 CD1A CD1B CD1C
39 basal cell carcinoma 1 9.9
40 basal cell carcinoma 9.9
41 papilloma 9.9
42 endometriosis 9.9
43 porokeratosis 9.9
44 inverted follicular keratosis 9.9
45 bullous pemphigoid 9.9
46 molluscum contagiosum 9.9
47 trichofolliculoma 9.9
48 warty dyskeratoma 9.9
49 lymphohistiocytoid mesothelioma 9.9 CD68 CEACAM5
50 gastric signet ring cell adenocarcinoma 9.9 CEACAM5 GATA3

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

GenomeRNAi Phenotypes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CD1C CD68 FGF7 GATA3 HAVCR1

MGI Mouse Phenotypes related to Clear Cell Acanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
2 digestive/alimentary MP:0005381 9.87 FGF10 FGFR2 GATA3 IL2RA KITLG NGFR
3 immune system MP:0005387 9.85 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
4 skeleton MP:0005390 9.61 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
5 vision/eye MP:0005391 9.17 FGF10 FGF7 FGFR2 GATA3 IL2RA KITLG

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

42
Skin, Testes

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 99)
# Title Authors Year
1
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. ( 30558902 )
2019
2
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. ( 30604543 )
2019
3
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. ( 30659646 )
2019
4
Solitary and Multiple Epidermolytic Acanthoma: A Demographic and Clinical Study of 131 Cases. ( 30663082 )
2019
5
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
6
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
7
Clear Cell Acanthoma on the Areola. ( 30261576 )
2018
8
Giant clear cell acanthoma with dermatoscopic white lines. ( 30116672 )
2018
9
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
10
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
11
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
12
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
13
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
14
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
15
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
16
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
17
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
18
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
19
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
20
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
21
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
22
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
23
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
24
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
25
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
26
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
27
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
28
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
29
Clear cell acanthoma. ( 24087787 )
2013
30
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
31
Clear cell acanthoma induced by a dermatofibroma. ( 23122021 )
2012
32
Clear cell acanthoma. ( 23171155 )
2012
33
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. ( 21070339 )
2011
34
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? ( 21317609 )
2011
35
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? ( 21252636 )
2011
36
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. ( 21965855 )
2011
37
Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation. ( 19889591 )
2010
38
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). ( 20500186 )
2010
39
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. ( 20931670 )
2010
40
Multiple eruptive clear cell acanthoma. ( 21886743 )
2010
41
A case of polypoid clear cell acanthoma on the nipple. ( 20711275 )
2010
42
Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma. ( 19397663 )
2009
43
Clear cell acanthoma: new observations on dermatoscopy. ( 18583817 )
2008
44
A glistening brown nodule. Pigmented clear cell acanthoma. ( 17310007 )
2007
45
Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. ( 17550563 )
2007
46
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. ( 17667172 )
2007
47
Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. ( 17083866 )
2006
48
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. ( 16984257 )
2006
49
Clear cell acanthoma occurring on the hallux: the first case report. ( 16987281 )
2006
50
Clear cell acanthoma successfully treated with a carbon dioxide laser. ( 16188196 )
2005

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD1A CD1B CD1C CD1D CD68 FGF10
2
Show member pathways
13.37 FGF10 FGF7 FGFR2 FLG IL2RA IVL
3
Show member pathways
13.3 CD1A CD1B CD1C CD1D FGF10 FGF7
4
Show member pathways
13.25 FGF10 FGF7 FGFR2 GATA3 IFNA1 IL2RA
5
Show member pathways
13.16 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
6
Show member pathways
12.94 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
7
Show member pathways
12.91 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
8
Show member pathways
12.78 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
9 12.64 FGF10 FGF7 FGFR2 KITLG NGFR
10 12.63 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
11
Show member pathways
12.6 FGF10 FGF7 FGFR2 KITLG NGFR
12
Show member pathways
12.55 FGF10 FGF7 FGFR2 KITLG NGFR
13
Show member pathways
12.28 FGF10 FGF7 FGFR2 NGFR
14 12.25 CEACAM5 GATA3 HAVCR1 IFNA1 IL2RA KITLG
15 11.95 CD1A CD1B CD1C CD1D CD1E
16 11.93 CD1A CD1B CD1C CD1D
17 11.88 FGF10 FGF7 KITLG NGFR
18
Show member pathways
11.86 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
19
Show member pathways
11.71 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
20 11.63 CD1A CD1C CD1D
21 11.62 CD1C CD68 CEACAM5 IL2RA KITLG
22 11.6 FGF10 FGF7 FGFR2 KITLG
23 11.15 CD1A CD1B CD1C CD1D CD1E IL2RA
24 10.96 FGF10 FGF7 FGFR2 NGFR

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 CD1A CD1C CD1D CD1E CEACAM5 FGFR2
2 lysosome GO:0005764 9.67 CD1B CD1C CD1D CD1E
3 endosome membrane GO:0010008 9.55 CD1A CD1B CD1C CD1D CD68
4 endosome GO:0005768 9.5 CD1A CD1B CD1C CD1D CD1E CD68
5 cell surface GO:0009986 9.32 CD1A CD1B CD1C CD1D CD1E CEACAM5
6 integral component of membrane GO:0016021 10.18 CD1A CD1B CD1C CD1D CD1E CD68
7 plasma membrane GO:0005886 10.13 CD1A CD1B CD1C CD1D CD1E CD68

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 CEACAM5 KITLG NGFR PDPN
2 adaptive immune response GO:0002250 9.96 CD1A CD1B CD1C CD1E IFNA1
3 regulation of immune response GO:0050776 9.93 CD1A CD1B CD1C CD1D
4 immune system process GO:0002376 9.91 CD1A CD1B CD1C CD1D CD1E GATA3
5 phosphatidylinositol phosphorylation GO:0046854 9.85 FGF10 FGF7 FGFR2 KITLG
6 lung development GO:0030324 9.84 FGF10 FGFR2 PDPN
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 FGF10 FGF7 KITLG
8 fibroblast growth factor receptor signaling pathway GO:0008543 9.82 FGF10 FGF7 FGFR2
9 inner ear morphogenesis GO:0042472 9.8 FGF10 FGFR2 GATA3
10 positive regulation of epithelial cell proliferation GO:0050679 9.8 FGF10 FGF7 FGFR2
11 MAPK cascade GO:0000165 9.8 FGF10 FGF7 FGFR2 IL2RA KITLG
12 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.76 FGF10 FGF7 FGFR2
13 positive regulation of protein kinase B signaling GO:0051897 9.72 FGF10 FGF7 FGFR2 GATA3 KITLG
14 positive regulation of MAPK cascade GO:0043410 9.7 FGF10 FGFR2
15 T cell activation involved in immune response GO:0002286 9.69 CD1C IFNA1
16 embryonic pattern specification GO:0009880 9.69 FGF10 FGFR2
17 positive regulation of Ras protein signal transduction GO:0046579 9.69 FGF10 KITLG
18 positive regulation of T cell differentiation GO:0045582 9.68 GATA3 IL2RA
19 protein localization to cell surface GO:0034394 9.68 FGF10 FGF7
20 animal organ morphogenesis GO:0009887 9.68 FGF10 FGFR2
21 embryonic digestive tract morphogenesis GO:0048557 9.68 FGF10 FGFR2
22 embryonic hemopoiesis GO:0035162 9.67 GATA3 KITLG
23 mesonephros development GO:0001823 9.66 FGF10 GATA3
24 organ growth GO:0035265 9.65 FGF10 FGFR2
25 positive regulation of keratinocyte migration GO:0051549 9.65 FGF10 FGF7
26 limb bud formation GO:0060174 9.65 FGF10 FGFR2
27 positive regulation of keratinocyte proliferation GO:0010838 9.64 FGF10 FGF7
28 bud elongation involved in lung branching GO:0060449 9.62 FGF10 FGFR2
29 lacrimal gland development GO:0032808 9.61 FGF10 FGFR2
30 otic vesicle formation GO:0030916 9.61 FGF10 FGFR2
31 hair follicle morphogenesis GO:0031069 9.61 FGF10 FGF7 FGFR2
32 epidermis morphogenesis GO:0048730 9.6 FGF10 FGFR2
33 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.59 FGF7 FGFR2
34 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.58 FGF10 FGFR2
35 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.57 FGF10 FGF7
36 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
37 branch elongation involved in salivary gland morphogenesis GO:0060667 9.52 FGF10 FGFR2
38 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.51 FGF10 FGFR2
39 mammary gland bud formation GO:0060615 9.49 FGF10 FGFR2
40 mesenchymal cell differentiation involved in lung development GO:0060915 9.48 FGF10 FGFR2
41 secretion by lung epithelial cell involved in lung growth GO:0061033 9.46 FGF10 FGF7
42 branching involved in salivary gland morphogenesis GO:0060445 9.43 FGF10 FGF7 FGFR2
43 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
44 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E
45 immune response GO:0006955 10.01 CD1A CD1B CD1C CD1D CD1E IL2RA

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.65 FGF10 FGF7 FGFR2 IL2RA KITLG
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.62 FGF10 FGF7 FGFR2 KITLG
3 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
4 1-phosphatidylinositol-3-kinase activity GO:0016303 9.54 FGF10 FGF7 FGFR2
5 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
6 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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