MCID: CLR001
MIFTS: 42

Clear Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 45 74
Acanthoma, Clear Cell 74
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 45 D049309
NCIt 51 C97041
SNOMED-CT 69 65540008

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to acanthoma and epidermolytic acanthoma. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Innate Immune System and Developmental Biology. Affiliated tissues include skin, ovary and testes, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and hematopoietic system

Wikipedia : 77 Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 acanthoma 32.2 FGF10 FGFR2
2 epidermolytic acanthoma 12.5
3 large cell acanthoma 12.5
4 pilar sheath acanthoma 12.3
5 acantholytic acanthoma 12.3
6 onychocytic matricoma 11.2
7 familial progressive hyperpigmentation 10.3 FGF7 KITLG
8 psoriasis 10.3
9 apert syndrome 10.3 FGF10 FGF7 FGFR2
10 muenke syndrome 10.3 FGF10 FGF7 FGFR2
11 lacrimoauriculodentodigital syndrome 10.3 FGF10 FGF7 FGFR2
12 pfeiffer syndrome 10.3 FGF10 FGF7 FGFR2
13 posttransplant acute limbic encephalitis 10.2
14 nevus, epidermal 10.2
15 ichthyosis 10.2
16 nodular hidradenoma 10.2 CEACAM5 KITLG
17 clear cell adenoma 10.2 CEACAM5 KITLG
18 predominantly cortical thymoma 10.2 IVL PDPN
19 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 PDPN
20 lentigines 10.1
21 muir-torre syndrome 10.1
22 epidermodysplasia verruciformis 1 10.1
23 melanoma 10.1
24 keratosis, seborrheic 10.1
25 psoriasis 7 10.1
26 psoriasis 11 10.1
27 psoriasis 13 10.1
28 autosomal recessive congenital ichthyosis 10.1
29 keratosis 10.1
30 squamous cell carcinoma 10.1
31 dermatitis 10.1
32 keratoacanthoma 10.1
33 cutaneous fibrous histiocytoma 10.1
34 cowden syndrome 10.1
35 in situ carcinoma 10.1
36 bowen's disease 10.1
37 multifocal motor neuropathy 10.1 CD1A CD1E
38 rheumatic disease 10.0 FLG IFNA1 IL2RA
39 adult xanthogranuloma 10.0 CD68 HAVCR1
40 eccrine adenocarcinoma 10.0 CD1C CEACAM5
41 fox-fordyce disease 9.9 CD68 CEACAM5
42 thymus lipoma 9.9 CD1A CD1B CD1C
43 immune system organ benign neoplasm 9.9 CD1A CD1B CD1C
44 basal cell carcinoma 1 9.9
45 squamous cell papilloma 9.9
46 basal cell carcinoma 9.9
47 papilloma 9.9
48 endometriosis 9.9
49 porokeratosis 9.9
50 inverted follicular keratosis 9.9

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

GenomeRNAi Phenotypes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 CD1C CD68 FGF7 GATA3 HAVCR1

MGI Mouse Phenotypes related to Clear Cell Acanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.96 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
2 digestive/alimentary MP:0005381 9.87 FGF10 FGFR2 GATA3 IL2RA KITLG NGFR
3 immune system MP:0005387 9.85 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
4 skeleton MP:0005390 9.61 CD1D CD68 FGF10 FGF7 FGFR2 GATA3
5 vision/eye MP:0005391 9.17 FGF10 FGF7 FGFR2 GATA3 IL2RA KITLG

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

42
Skin, Ovary, Testes, Uterus, Liver, Thymus

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 239)
# Title Authors Year
1
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. ( 30659646 )
2019
2
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. ( 30663082 )
2019
3
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. ( 30940575 )
2019
4
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. ( 31078506 )
2019
5
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. ( 30604543 )
2019
6
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2018
7
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2018
8
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2018
9
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
10
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
11
Longitudinal subungual acanthoma: one denomination for various clinical presentations. ( 29705997 )
2018
12
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. ( 29735169 )
2018
13
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
14
Giant clear cell acanthoma with dermatoscopic white lines. ( 30116672 )
2018
15
Clear Cell Acanthoma on the Areola. ( 30261576 )
2018
16
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. ( 30558902 )
2018
17
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
18
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
19
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
20
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
21
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
22
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. ( 29085717 )
2017
23
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
24
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
25
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2016
26
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2016
27
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2016
28
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
29
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
30
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
31
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
32
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
33
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
34
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
35
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2015
36
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2015
37
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
38
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2015
39
Porokeratotic acanthoma. ( 25631132 )
2015
40
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
41
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
42
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
43
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? ( 23651324 )
2014
44
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
45
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
46
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
47
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
48
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
49
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
50
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.85 CD1A CD1B CD1C CD1D CD68 FGF10
2
Show member pathways
13.37 FGF10 FGF7 FGFR2 FLG IL2RA IVL
3
Show member pathways
13.3 CD1A CD1B CD1C CD1D FGF10 FGF7
4
Show member pathways
13.25 FGF10 FGF7 FGFR2 GATA3 IFNA1 IL2RA
5
Show member pathways
13.16 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
6
Show member pathways
12.94 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
7
Show member pathways
12.91 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
8
Show member pathways
12.78 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
9 12.64 FGF10 FGF7 FGFR2 KITLG NGFR
10 12.63 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
11
Show member pathways
12.6 FGF10 FGF7 FGFR2 KITLG NGFR
12
Show member pathways
12.55 FGF10 FGF7 FGFR2 KITLG NGFR
13
Show member pathways
12.28 FGF10 FGF7 FGFR2 NGFR
14 12.25 CEACAM5 GATA3 HAVCR1 IFNA1 IL2RA KITLG
15 11.95 CD1A CD1B CD1C CD1D CD1E
16 11.93 CD1A CD1B CD1C CD1D
17 11.88 FGF10 FGF7 KITLG NGFR
18
Show member pathways
11.86 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
19
Show member pathways
11.71 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
20 11.63 CD1A CD1C CD1D
21 11.62 CD1C CD68 CEACAM5 IL2RA KITLG
22 11.6 FGF10 FGF7 FGFR2 KITLG
23 11.15 CD1A CD1B CD1C CD1D CD1E IL2RA
24 10.96 FGF10 FGF7 FGFR2 NGFR

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.86 CD1A CD1C CD1D CD1E CEACAM5 FGFR2
2 lysosome GO:0005764 9.67 CD1B CD1C CD1D CD1E
3 endosome membrane GO:0010008 9.55 CD1A CD1B CD1C CD1D CD68
4 endosome GO:0005768 9.5 CD1A CD1B CD1C CD1D CD1E CD68
5 cell surface GO:0009986 9.17 CD1B CD1D CEACAM5 FGF10 FGFR2 IL2RA
6 integral component of membrane GO:0016021 10.18 CD1A CD1B CD1C CD1D CD1E CD68
7 plasma membrane GO:0005886 10.13 CD1A CD1B CD1C CD1D CD1E CD68

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.96 CEACAM5 KITLG NGFR PDPN
2 adaptive immune response GO:0002250 9.95 CD1A CD1B CD1C CD1E IFNA1
3 regulation of immune response GO:0050776 9.92 CD1A CD1B CD1C CD1D
4 immune system process GO:0002376 9.91 CD1A CD1B CD1C CD1D CD1E GATA3
5 lung development GO:0030324 9.83 FGF10 FGFR2 PDPN
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.83 FGF10 FGF7 KITLG
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.81 FGF10 FGF7 FGFR2
8 MAPK cascade GO:0000165 9.8 FGF10 FGF7 FGFR2 IL2RA KITLG
9 inner ear morphogenesis GO:0042472 9.79 FGF10 FGFR2 GATA3
10 positive regulation of epithelial cell proliferation GO:0050679 9.79 FGF10 FGF7 FGFR2
11 positive regulation of protein kinase B signaling GO:0051897 9.72 FGF10 FGF7 FGFR2 GATA3 KITLG
12 positive regulation of MAPK cascade GO:0043410 9.69 FGF10 FGFR2
13 T cell activation involved in immune response GO:0002286 9.69 CD1C IFNA1
14 embryonic pattern specification GO:0009880 9.68 FGF10 FGFR2
15 positive regulation of Ras protein signal transduction GO:0046579 9.68 FGF10 KITLG
16 positive regulation of T cell differentiation GO:0045582 9.68 GATA3 IL2RA
17 protein localization to cell surface GO:0034394 9.68 FGF10 FGF7
18 animal organ morphogenesis GO:0009887 9.67 FGF10 FGFR2
19 embryonic digestive tract morphogenesis GO:0048557 9.67 FGF10 FGFR2
20 embryonic hemopoiesis GO:0035162 9.67 GATA3 KITLG
21 mesonephros development GO:0001823 9.65 FGF10 GATA3
22 organ growth GO:0035265 9.65 FGF10 FGFR2
23 positive regulation of keratinocyte migration GO:0051549 9.64 FGF10 FGF7
24 limb bud formation GO:0060174 9.64 FGF10 FGFR2
25 positive regulation of keratinocyte proliferation GO:0010838 9.63 FGF10 FGF7
26 bud elongation involved in lung branching GO:0060449 9.61 FGF10 FGFR2
27 hair follicle morphogenesis GO:0031069 9.61 FGF10 FGF7 FGFR2
28 lacrimal gland development GO:0032808 9.6 FGF10 FGFR2
29 otic vesicle formation GO:0030916 9.59 FGF10 FGFR2
30 epidermis morphogenesis GO:0048730 9.58 FGF10 FGFR2
31 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.58 FGF7 FGFR2
32 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.57 FGF10 FGFR2
33 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.56 FGF10 FGF7
34 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
35 branch elongation involved in salivary gland morphogenesis GO:0060667 9.52 FGF10 FGFR2
36 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.51 FGF10 FGFR2
37 mammary gland bud formation GO:0060615 9.49 FGF10 FGFR2
38 mesenchymal cell differentiation involved in lung development GO:0060915 9.48 FGF10 FGFR2
39 secretion by lung epithelial cell involved in lung growth GO:0061033 9.46 FGF10 FGF7
40 branching involved in salivary gland morphogenesis GO:0060445 9.43 FGF10 FGF7 FGFR2
41 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
42 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E
43 immune response GO:0006955 10.01 CD1A CD1B CD1C CD1D CD1E IL2RA

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
3 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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