MCID: CLR001
MIFTS: 39

Clear Cell Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 44 73
Acanthoma, Clear Cell 73
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 44 D049309
NCIt 50 C97041
SNOMED-CT 68 254670002 65540008
UMLS 73 C0333992

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to acanthoma and familial progressive hyperpigmentation. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. Affiliated tissues include testes and skin, and related phenotypes are digestive/alimentary and skeleton

Wikipedia : 76 Clear cell acanthoma (also known as \"Acanthome cellules claires of Degos and Civatte,\" \"Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 acanthoma 32.4 FGF10 FGFR2
2 familial progressive hyperpigmentation 10.6 FGF7 KITLG
3 apert syndrome 10.6 FGF10 FGF7 FGFR2
4 lacrimoauriculodentodigital syndrome 10.5 FGF10 FGF7 FGFR2
5 muenke syndrome 10.5 FGF10 FGF7 FGFR2
6 pfeiffer syndrome 10.5 FGF10 FGF7 FGFR2
7 psoriasis 10.1
8 acute dacryocystitis 10.1 CALM1 CALM2 CALM3
9 external ear disease 10.1 CALM1 CALM2 CALM3
10 long qt syndrome 15 10.1 CALM1 CALM2 CALM3
11 otitis externa 10.1 CALM1 CALM2 CALM3
12 nodular hidradenoma 10.1 CEACAM5 KITLG
13 otomycosis 10.1 CALM1 CALM2 CALM3
14 spontaneous ocular nystagmus 10.1 CALM1 CALM2 CALM3
15 sporotrichosis 10.1 CALM1 CALM2 CALM3
16 nevus, epidermal 10.1
17 deafness, autosomal recessive 44 10.1 CALM1 CALM2 CALM3
18 dystonia 24 10.0 CALM1 CALM2 CALM3
19 gastric signet ring cell adenocarcinoma 10.0 CEACAM5 GATA3
20 triosephosphate isomerase deficiency 10.0 CALM1 CALM2 CALM3
21 leber congenital amaurosis 2 10.0 CALM1 CALM2 CALM3
22 primary systemic mycosis 10.0 CALM1 CALM2 CALM3
23 cardiomyopathy, dilated, 1a 10.0 CALM1 CALM2 CALM3
24 cardiomyopathy, dilated, 1p 10.0 CALM1 CALM2 CALM3
25 deafness, autosomal dominant 2a 10.0 CALM1 CALM2 CALM3
26 primary cutaneous amyloidosis 10.0 CALM1 CALM2 CALM3
27 predominantly cortical thymoma 10.0 IVL PDPN
28 catecholaminergic polymorphic ventricular tachycardia 9.9 CALM1 CALM2 CALM3
29 adult xanthogranuloma 9.9 CD68 HAVCR1
30 psoriasis 2 9.9
31 psoriasis 7 9.9
32 psoriasis 11 9.9
33 psoriasis 13 9.9
34 keratosis 9.9
35 ichthyosis 9.9
36 squamous cell carcinoma 9.9
37 keratoacanthoma 9.9
38 bowen's disease 9.9
39 clear cell adenoma 9.8 CEACAM5 KITLG
40 long qt syndrome 1 9.8 CALM1 CALM2 CALM3
41 dermatitis, atopic 9.8 FLG GATA3 IL2RA IVL
42 fox-fordyce disease 9.7 CD68 CEACAM5
43 aggressive digital papillary adenocarcinoma 9.6 CEACAM5 PDPN
44 lymphohistiocytoid mesothelioma 9.5 CD68 CEACAM5
45 discoid lupus erythematosus 9.2 FLG IFNA1 IVL PDPN
46 congenital epulis 9.2 CD68 CEACAM5 HAVCR1 NGFR
47 miliaria 9.1 CD68 CEACAM5 PDPN
48 liver sarcoma 9.0 CD68 CEACAM5

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

MGI Mouse Phenotypes related to Clear Cell Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.7 IL2RA KITLG NGFR PDPN FGF10 FGFR2
2 skeleton MP:0005390 9.56 GATA3 KITLG NGFR PDPN CD68 FGF10
3 vision/eye MP:0005391 9.17 GATA3 IL2RA KITLG NGFR FGF10 FGF7

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

41
Testes, Skin

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 92)
# Title Authors Year
1
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
2
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
3
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
4
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
5
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
6
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
7
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
8
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
9
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
10
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
11
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
12
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
13
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
14
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
15
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
16
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
17
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
18
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
19
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
20
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
21
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
22
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
23
Clear cell acanthoma. ( 24087787 )
2013
24
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
25
Clear cell acanthoma induced by a dermatofibroma. ( 23122021 )
2012
26
Clear cell acanthoma. ( 23171155 )
2012
27
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. ( 21070339 )
2011
28
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? ( 21317609 )
2011
29
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? ( 21252636 )
2011
30
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. ( 21965855 )
2011
31
Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation. ( 19889591 )
2010
32
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). ( 20500186 )
2010
33
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. ( 20931670 )
2010
34
Multiple eruptive clear cell acanthoma. ( 21886743 )
2010
35
A case of polypoid clear cell acanthoma on the nipple. ( 20711275 )
2010
36
Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma. ( 19397663 )
2009
37
Clear cell acanthoma: new observations on dermatoscopy. ( 18583817 )
2008
38
A glistening brown nodule. Pigmented clear cell acanthoma. ( 17310007 )
2007
39
Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. ( 17550563 )
2007
40
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. ( 17667172 )
2007
41
Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. ( 17083866 )
2006
42
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. ( 16984257 )
2006
43
Clear cell acanthoma occurring on the hallux: the first case report. ( 16987281 )
2006
44
Clear cell acanthoma successfully treated with a carbon dioxide laser. ( 16188196 )
2005
45
Clear cell acanthoma occurring in a split-thickness skin graft. ( 16327592 )
2005
46
A case of polypoid clear cell acanthoma on the scrotum. ( 15187345 )
2004
47
Dermoscopy of clear-cell acanthoma differs from dermoscopy of psoriasis. ( 14657649 )
2003
48
Videodermatoscopy improves the clinical diagnostic accuracy of multiple clear cell acanthoma. ( 14721785 )
2003
49
Psoriasis-like dermoscopic pattern of clear cell acanthoma. ( 12834460 )
2003
50
Polypoid clear cell acanthoma of unusual size. ( 11174404 )
2001

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CALM1 CALM2 CALM3 CD68 FGF10 FGF7
2
Show member pathways
13.7 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
3
Show member pathways
13.51 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
4
Show member pathways
13.48 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
5
Show member pathways
13.43 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
6
Show member pathways
13.39 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
7
Show member pathways
13.28 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
8
Show member pathways
13.27 CALM1 CALM2 CALM3 CEACAM5 GATA3 IFNA1
9
Show member pathways
13.25 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
10
Show member pathways
13.24 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
11
Show member pathways
13.23 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
12
Show member pathways
13.03 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
13
Show member pathways
12.93 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
14
Show member pathways
12.91 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
15
Show member pathways
12.86 CALM1 CALM2 CALM3 IFNA1 IL2RA
16 12.75 FGF10 FGF7 FGFR2 KITLG NGFR
17
Show member pathways
12.73 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
18
Show member pathways
12.64 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
19
Show member pathways
12.55 CALM1 CALM2 CALM3 IFNA1
20 12.5 CEACAM5 GATA3 HAVCR1 IFNA1 IL2RA KITLG
21
Show member pathways
12.5 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
22
Show member pathways
12.49 CALM1 CALM2 CALM3 IFNA1
23
Show member pathways
12.47 CALM1 CALM2 CALM3 GATA3
24
Show member pathways
12.38 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
25
Show member pathways
12.37 CALM1 CALM2 CALM3 IL2RA
26 12.33 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
27
Show member pathways
12.25 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
28 12.22 CALM1 CALM2 CALM3 IFNA1
29 12.07 FGF10 FGF7 KITLG NGFR
30
Show member pathways
11.99 CALM1 CALM2 CALM3
31 11.99 CD68 CEACAM5 IL2RA KITLG
32
Show member pathways
11.97 CALM1 CALM2 CALM3
33
Show member pathways
11.95 CALM1 CALM2 CALM3
34
Show member pathways
11.92 CALM1 CALM2 CALM3
35 11.91 CALM1 CALM2 CALM3
36 11.9 CALM1 CALM2 CALM3
37 11.88 CALM1 CALM2 CALM3
38
Show member pathways
11.88 CALM1 CALM2 CALM3
39
Show member pathways
11.85 CALM1 CALM2 CALM3
40
Show member pathways
11.84 CALM1 CALM2 CALM3
41
Show member pathways
11.77 CALM1 CALM2 CALM3
42
Show member pathways
11.77 CALM1 CALM2 CALM3
43 11.75 CALM1 CALM2 CALM3
44
Show member pathways
11.74 CALM1 CALM2 CALM3
45 11.73 CALM1 CALM2 CALM3
46
Show member pathways
11.68 CALM1 CALM2 CALM3 GATA3 IL2RA
47 11.67 CALM1 CALM2 CALM3
48
Show member pathways
11.67 CALM1 CALM2 CALM3 IL2RA
49 11.65 CALM1 CALM2 CALM3
50
Show member pathways
11.61 CALM1 CALM2 CALM3 IL2RA

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 CALM1 CEACAM5 FGF10 FGF7 FGFR2 IFNA1
2 spindle pole GO:0000922 9.58 CALM1 CALM2 CALM3
3 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
4 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
5 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
6 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3
7 plasma membrane GO:0005886 10.06 CALM1 CALM2 CALM3 CD68 CEACAM5 FGF10

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.89 FGF10 FGFR2 GATA3
2 epidermis development GO:0008544 9.89 FGF10 FGF7 FLG
3 lung development GO:0030324 9.88 FGF10 FGFR2 PDPN
4 phosphatidylinositol phosphorylation GO:0046854 9.88 FGF10 FGF7 FGFR2 KITLG
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 FGF10 FGF7 KITLG
6 fibroblast growth factor receptor signaling pathway GO:0008543 9.87 FGF10 FGF7 FGFR2
7 inner ear morphogenesis GO:0042472 9.86 FGF10 FGFR2 GATA3
8 positive regulation of epithelial cell proliferation GO:0050679 9.85 FGF10 FGF7 FGFR2
9 response to calcium ion GO:0051592 9.85 CALM1 CALM2 CALM3
10 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.83 FGF10 FGF7 FGFR2
11 positive regulation of protein serine/threonine kinase activity GO:0071902 9.83 CALM1 CALM2 CALM3
12 substantia nigra development GO:0021762 9.82 CALM1 CALM2 CALM3
13 digestive tract development GO:0048565 9.81 FGF10 FGFR2 GATA3
14 regulation of cytokinesis GO:0032465 9.81 CALM1 CALM2 CALM3
15 regulation of heart rate GO:0002027 9.8 CALM1 CALM2 CALM3
16 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.8 CALM1 CALM2 CALM3
17 positive regulation of protein kinase B signaling GO:0051897 9.8 FGF10 FGF7 FGFR2 GATA3 KITLG
18 hair follicle morphogenesis GO:0031069 9.76 FGF10 FGF7 FGFR2
19 positive regulation of protein autophosphorylation GO:0031954 9.74 CALM1 CALM2 CALM3
20 positive regulation of protein dephosphorylation GO:0035307 9.73 CALM1 CALM2 CALM3
21 positive regulation of Ras protein signal transduction GO:0046579 9.72 FGF10 KITLG
22 embryonic digestive tract morphogenesis GO:0048557 9.72 FGF10 FGFR2
23 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.72 CALM1 CALM2 CALM3
24 positive regulation of T cell differentiation GO:0045582 9.71 GATA3 IL2RA
25 embryonic hemopoiesis GO:0035162 9.71 GATA3 KITLG
26 mesonephros development GO:0001823 9.71 FGF10 GATA3
27 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.71 CALM1 CALM2 CALM3
28 organ growth GO:0035265 9.7 FGF10 FGFR2
29 limb bud formation GO:0060174 9.7 FGF10 FGFR2
30 regulation of cardiac muscle contraction GO:0055117 9.7 CALM1 CALM2 CALM3
31 positive regulation of keratinocyte proliferation GO:0010838 9.69 FGF10 FGF7
32 positive regulation of keratinocyte migration GO:0051549 9.69 FGF10 FGF7
33 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.69 CALM1 CALM2 CALM3
34 bud elongation involved in lung branching GO:0060449 9.68 FGF10 FGFR2
35 otic vesicle formation GO:0030916 9.68 FGF10 FGFR2
36 epidermis morphogenesis GO:0048730 9.67 FGF10 FGFR2
37 lacrimal gland development GO:0032808 9.67 FGF10 FGFR2
38 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.67 CALM1 CALM2 CALM3
39 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.66 FGF10 FGFR2
40 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.66 FGF7 FGFR2
41 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.65 CALM1 CALM2 CALM3
42 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.64 FGF10 FGF7
43 detection of calcium ion GO:0005513 9.63 CALM1 CALM2 CALM3
44 MAPK cascade GO:0000165 9.63 CALM1 FGF10 FGF7 FGFR2 IL2RA KITLG
45 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.62 FGF10 FGFR2
46 mammary gland bud formation GO:0060615 9.61 FGF10 FGFR2
47 branch elongation involved in salivary gland morphogenesis GO:0060667 9.61 FGF10 FGFR2
48 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.61 CALM1 CALM2 CALM3
49 mesenchymal cell differentiation involved in lung development GO:0060915 9.6 FGF10 FGFR2
50 secretion by lung epithelial cell involved in lung growth GO:0061033 9.59 FGF10 FGF7

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.67 CALM1 CALM2 CALM3
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.67 FGF10 FGF7 FGFR2 KITLG
3 1-phosphatidylinositol-3-kinase activity GO:0016303 9.63 FGF10 FGF7 FGFR2
4 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.58 CALM1 CALM2 CALM3
6 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
7 calcium channel inhibitor activity GO:0019855 9.48 CALM1 CALM2
8 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 9.13 CALM1 CALM2 CALM3
11 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.1 CALM1 FGF10 FGF7 FGFR2 IL2RA KITLG

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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