MCID: CLR001
MIFTS: 34

Clear Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 43 71
Acanthoma, Clear Cell 71
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 43 D049309
NCIt 49 C97041
SNOMED-CT 67 65540008
UMLS 71 C0333992 C0846967

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to epidermolytic acanthoma and acanthoma. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are MAPK signaling pathway and Gastric cancer. Affiliated tissues include skin, ovary and uterus.

Wikipedia : 74 Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 epidermolytic acanthoma 33.4 KRT10 IVL
2 acanthoma 31.0 FGFR2 FGF7 FGF10 CLEC2A
3 epidermolytic hyperkeratosis 29.9 KRT10 IVL FLG
4 eccrine acrospiroma 29.7 KRT10 CLEC2A
5 molluscum contagiosum 29.7 IVL FLG
6 porokeratosis 29.6 IVL FLG FGFR2
7 bowen's disease 29.6 KRT10 IVL
8 keratosis, seborrheic 29.5 KRT10 IVL CLEC2A
9 keratosis 29.5 KRT10 IVL FLG
10 ichthyosis 29.5 KRT10 IVL FLG
11 nevus, epidermal 29.4 KRT10 IVL FGFR2
12 palmoplantar keratoderma, epidermolytic 29.3 KRT10 FLG
13 lichen planus 29.3 KRT10 IVL FLG
14 papilloma 29.2 KRT10 IVL FLG
15 psoriasis 29.2 KRT10 IVL FLG FGF7
16 discoid lupus erythematosus 29.1 KRT10 IVL FLG
17 keratoacanthoma 29.1 KRT10 IVL FLG
18 epidermolysis bullosa 29.1 KRT10 IVL FLG
19 autosomal recessive congenital ichthyosis 29.0 KRT10 IVL FLG
20 skin disease 28.6 KRT10 IVL FLG FGF7
21 large cell acanthoma 12.6
22 pilar sheath acanthoma 12.4
23 acantholytic acanthoma 12.4
24 onychocytic matricoma 11.7
25 erythrokeratoderma ''en cocardes'' 10.6
26 autosomal dominant epidermolytic ichthyosis 10.6
27 pustulosis of palm and sole 10.5
28 lentigines 10.4
29 actinic keratosis 10.4
30 dermatitis 10.3
31 inverted follicular keratosis 10.3
32 posttransplant acute limbic encephalitis 10.3
33 muir-torre syndrome 10.3
34 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
35 basal cell carcinoma 10.2
36 adenoma 10.2
37 dowling-degos disease 1 10.2
38 varicose veins 10.2
39 dermatitis, atopic 10.2
40 epidermodysplasia verruciformis 1 10.2
41 dacryocystocele 10.1 FGFR2 FGF10
42 bronchopulmonary dysplasia 10.1 FGF7 FGF10
43 melanoma 10.1
44 skin carcinoma 10.1
45 bowenoid papulosis 10.1
46 trichofolliculoma 10.1
47 warty dyskeratoma 10.1
48 pemphigus vegetans 10.1
49 renal cell carcinoma, nonpapillary 10.1
50 squamous cell papilloma 10.1

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

40
Skin, Ovary, Uterus, Prostate, Cervix, Colon, Liver

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 414)
# Title Authors PMID Year
1
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 61
31436573 2020
2
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 61
30480645 2020
3
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 61
31078506 2019
4
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 61
30839347 2019
5
Dermoscopy of subungual acantholytic dyskeratotic acanthoma. 61
31532837 2019
6
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 61
31559241 2019
7
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
8
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. 61
30659646 2019
9
Pale (Clear) Cell Acanthoma of the Palate. 61
31230231 2019
10
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 61
30940575 2019
11
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 61
30663082 2019
12
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. 61
31700841 2019
13
Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient. 61
31046909 2019
14
Onychocytic matricoma. 61
31090828 2019
15
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. 61
30558902 2019
16
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. 61
30604543 2019
17
Clear Cell Acanthoma with Atypical Location -Case Report and Literature Review. 61
31123619 2018
18
Longitudinal subungual acanthoma: one denomination for various clinical presentations. 61
29705997 2018
19
Clear Cell Acanthoma on the Areola. 61
30261576 2018
20
Giant clear cell acanthoma with dermatoscopic white lines. 61
30116672 2018
21
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 61
29633447 2018
22
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. 61
29735169 2018
23
Dermoscopic features of clear cell acanthoma. 61
29924237 2018
24
Multiple Eruptive Clear Cell Acanthoma. 61
29692468 2018
25
Case of podoplanin-positive clear cell acanthoma. 61
28266032 2018
26
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. 61
28857272 2018
27
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. 61
28609346 2018
28
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 61
29090469 2018
29
Familial seborrhoeic keratosis associated with multiple 'pure reticulated acanthomas' and infundibulocystic basal cell carcinomas. 61
28627087 2017
30
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. 61
28426905 2017
31
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. 61
28470879 2017
32
Germinotropic Onychocytic Matricoma: A New Histopathologic Subtype of Onychocytic Matricoma in the Light of the Microanatomy of the Normal Nail Unit, With Special Reference to Nail Mesenchyme. 61
28169867 2017
33
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. 61
29085717 2017
34
Reticulated acanthoma with sebaceous differentiation. 61
28492170 2017
35
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. 61
28868008 2017
36
[Multiple epidermolytic acanthomas of the genitalia]. 61
27789051 2017
37
Acanthoma Fissuratum: Lest we Forget. 61
28405560 2017
38
Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome - a case report. 61
27682856 2017
39
"String of pearls pattern": report of three cases of non clear-cell acanthoma. 61
29267474 2017
40
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. 61
29267438 2017
41
Clear Cell Acanthoma of the Areola and Nipple. 61
27206609 2016
42
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. 61
27814733 2016
43
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. 61
26945829 2016
44
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 61
27153339 2016
45
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 61
25186214 2016
46
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. 61
26885606 2016
47
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 61
27648388 2016
48
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. 61
27185430 2016
49
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 61
27034569 2016
50
Multiple pigmented clear cell acanthoma in an African patient. 61
25414053 2016

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.42 FGFR2 FGF7 FGF10
2
Show member pathways
12.41 FGFR2 FGF7 FGF10
3
Show member pathways
12.38 FGFR2 FGF7 FGF10
4
Show member pathways
12.36 FGFR2 FGF7 FGF10
5
Show member pathways
12.33 FGFR2 FGF7 FGF10
6
Show member pathways
12.31 KRT10 IVL FLG FGFR2 FGF7 FGF10
7
Show member pathways
12.3 FGFR2 FGF7 FGF10
8 12.25 FGFR2 FGF7 FGF10
9
Show member pathways
12.17 FGFR2 FGF7 FGF10
10
Show member pathways
12.06 FGFR2 FGF7 FGF10
11
Show member pathways
12.03 KRT10 IVL FLG
12
Show member pathways
11.92 FGFR2 FGF7 FGF10
13
Show member pathways
11.9 FGFR2 FGF7 FGF10
14
Show member pathways
11.88 FGFR2 FGF7 FGF10
15
Show member pathways
11.84 FGFR2 FGF7 FGF10
16
Show member pathways
11.62 FGFR2 FGF7 FGF10
17
Show member pathways
11.33 FGFR2 FGF7 FGF10
18 11.32 FGFR2 FGF7 FGF10
19 11.07 FGFR2 FGF7

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.13 FLG FGFR2 FGF10
2 cornified envelope GO:0001533 8.8 KRT10 IVL FLG

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.82 FGFR2 FGF7 FGF10
2 positive regulation of protein kinase B signaling GO:0051897 9.8 FGFR2 FGF7 FGF10
3 cornification GO:0070268 9.76 KRT10 IVL FLG
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.7 FGFR2 FGF7 FGF10
5 epithelial cell differentiation GO:0030855 9.67 FGFR2 FGF10
6 inner ear morphogenesis GO:0042472 9.67 FGFR2 FGF10
7 actin cytoskeleton reorganization GO:0031532 9.67 FGF7 FGF10
8 positive regulation of epithelial cell proliferation GO:0050679 9.67 FGFR2 FGF7 FGF10
9 positive chemotaxis GO:0050918 9.66 FGF7 FGF10
10 positive regulation of cell division GO:0051781 9.66 FGFR2 FGF7
11 positive regulation of Wnt signaling pathway GO:0030177 9.65 FGFR2 FGF10
12 lung alveolus development GO:0048286 9.65 FGFR2 FGF10
13 digestive tract development GO:0048565 9.65 FGFR2 FGF10
14 protein localization to cell surface GO:0034394 9.64 FGF7 FGF10
15 regulation of smoothened signaling pathway GO:0008589 9.63 FGFR2 FGF10
16 embryonic pattern specification GO:0009880 9.63 FGFR2 FGF10
17 keratinocyte differentiation GO:0030216 9.63 KRT10 IVL FLG
18 embryonic digestive tract morphogenesis GO:0048557 9.62 FGFR2 FGF10
19 positive regulation of keratinocyte proliferation GO:0010838 9.61 FGF7 FGF10
20 positive regulation of keratinocyte migration GO:0051549 9.61 FGF7 FGF10
21 organ growth GO:0035265 9.6 FGFR2 FGF10
22 limb bud formation GO:0060174 9.59 FGFR2 FGF10
23 bud elongation involved in lung branching GO:0060449 9.58 FGFR2 FGF10
24 epidermis morphogenesis GO:0048730 9.57 FGFR2 FGF10
25 lacrimal gland development GO:0032808 9.56 FGFR2 FGF10
26 otic vesicle formation GO:0030916 9.55 FGFR2 FGF10
27 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.54 FGFR2 FGF7
28 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.51 FGFR2 FGF10
29 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.48 FGF7 FGF10
30 secretion by lung epithelial cell involved in lung growth GO:0061033 9.43 FGF7 FGF10
31 mesenchymal cell differentiation involved in lung development GO:0060915 9.4 FGFR2 FGF10
32 branch elongation involved in salivary gland morphogenesis GO:0060667 9.37 FGFR2 FGF10
33 peptide cross-linking GO:0018149 9.33 KRT10 IVL FLG
34 mammary gland bud formation GO:0060615 9.32 FGFR2 FGF10
35 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.26 FGFR2 FGF10
36 hair follicle morphogenesis GO:0031069 9.13 FGFR2 FGF7 FGF10
37 branching involved in salivary gland morphogenesis GO:0060445 8.8 FGFR2 FGF7 FGF10

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.26 FGF7 FGF10
2 fibroblast growth factor receptor binding GO:0005104 9.16 FGF7 FGF10
3 heparin binding GO:0008201 9.13 FGFR2 FGF7 FGF10
4 structural constituent of epidermis GO:0030280 8.62 KRT10 FLG

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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