MCID: CLR001
MIFTS: 43

Clear Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 44 73
Acanthoma, Clear Cell 73
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 44 D049309
NCIt 50 C97041
SNOMED-CT 68 65540008

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to acanthoma and epidermolytic acanthoma. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Innate Immune System and GPCR Pathway. Affiliated tissues include skin, testes and liver, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 76 Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 acanthoma 32.0 FGF10 FGFR2
2 epidermolytic acanthoma 12.5
3 large cell acanthoma 12.5
4 pilar sheath acanthoma 12.3
5 acantholytic acanthoma 12.2
6 onychocytic matricoma 11.2
7 psoriasis 10.3
8 nevus, epidermal 10.2
9 ichthyosis 10.2
10 familial progressive hyperpigmentation 10.2 FGF7 KITLG
11 apert syndrome 10.2 FGF10 FGF7 FGFR2
12 muenke syndrome 10.2 FGF10 FGF7 FGFR2
13 lacrimoauriculodentodigital syndrome 10.2 FGF10 FGF7 FGFR2
14 pfeiffer syndrome 10.2 FGF10 FGF7 FGFR2
15 psoriasis 2 10.0
16 psoriasis 7 10.0
17 psoriasis 11 10.0
18 psoriasis 13 10.0
19 autosomal recessive congenital ichthyosis 10.0
20 keratosis 10.0
21 squamous cell carcinoma 10.0
22 keratoacanthoma 10.0
23 cowden disease 10.0
24 in situ carcinoma 10.0
25 bowen's disease 10.0
26 muir-torre syndrome 10.0
27 epidermodysplasia verruciformis 10.0
28 melanoma 10.0
29 long qt syndrome 15 10.0 CALM1 CALM2 CALM3
30 nodular hidradenoma 10.0 CEACAM5 KITLG
31 long qt syndrome 1 10.0 CALM1 CALM2 CALM3
32 otomycosis 10.0 CALM1 CALM2 CALM3
33 external ear disease 10.0 CALM1 CALM2 CALM3
34 emery-dreifuss muscular dystrophy 5, autosomal dominant 10.0 CALM1 CALM2 CALM3
35 sporotrichosis 10.0 CALM1 CALM2 CALM3
36 otitis externa 10.0 CALM1 CALM2 CALM3
37 spontaneous ocular nystagmus 10.0 CALM1 CALM2 CALM3
38 deafness, autosomal recessive 44 10.0 CALM1 CALM2 CALM3
39 acute dacryocystitis 10.0 CALM1 CALM2 CALM3
40 dystonia 24 10.0 CALM1 CALM2 CALM3
41 gestational choriocarcinoma 10.0 CALM1 CALM2 CALM3
42 triosephosphate isomerase deficiency 10.0 CALM1 CALM2 CALM3
43 leber congenital amaurosis 2 10.0 CALM1 CALM2 CALM3
44 tinea unguium 10.0 CALM1 CALM2 CALM3
45 primary systemic mycosis 10.0 CALM1 CALM2 CALM3
46 cardiomyopathy, dilated, 1a 10.0 CALM1 CALM2 CALM3
47 cardiomyopathy, dilated, 1p 10.0 CALM1 CALM2 CALM3
48 phaeohyphomycosis 10.0 CALM1 CALM2 CALM3
49 deafness, autosomal dominant 2a 10.0 CALM1 CALM2 CALM3
50 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 10.0 CALM1 CALM2 CALM3

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

MGI Mouse Phenotypes related to Clear Cell Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CD68 FGF10 FGF7 FGFR2 GATA3 IL2RA
2 digestive/alimentary MP:0005381 9.8 FGF10 FGFR2 GATA3 IL2RA KITLG NGFR
3 skeleton MP:0005390 9.56 CD68 FGF10 FGF7 FGFR2 GATA3 KITLG
4 vision/eye MP:0005391 9.17 FGF10 FGF7 FGFR2 GATA3 IL2RA KITLG

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

41
Skin, Testes, Liver, Breast

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 100)
# Title Authors Year
1
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
2
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
3
Giant clear cell acanthoma with dermatoscopic white lines. ( 30116672 )
2018
4
Clear Cell Acanthoma on the Areola. ( 30261576 )
2018
5
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
6
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
7
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
8
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
9
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
10
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
11
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
12
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2015
13
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
14
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
15
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
16
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
17
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
18
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
19
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
20
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
21
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
22
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
23
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013
24
Clear cell acanthoma of the areola and nipple: clinical, histopathological, and immunohistochemical features of two Brazilian cases. ( 23539008 )
2013
25
Clear cell acanthoma. ( 24087787 )
2013
26
Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology? ( 24117902 )
2013
27
Acanthoma fissuratum on the penis. ( 21913907 )
2013
28
Clear cell acanthoma induced by a dermatofibroma. ( 23122021 )
2012
29
Clear cell acanthoma. ( 23171155 )
2012
30
Value of the Tzanck smear test and dermatoscopy in the diagnosis of clear cell acanthoma. ( 21070339 )
2011
31
Disseminated eruptive clear cell acanthoma with spontaneous regression: further evidence of an inflammatory origin? ( 21317609 )
2011
32
Eccrine syringofibroadenoma and clear cell acanthoma: an association by chance? ( 21252636 )
2011
33
Hemosiderotic clear-cell acanthoma: a pigmented mimicker. ( 21965855 )
2011
34
Isolated epidermolytic acanthoma in a renal transplant recipient. ( 21909223 )
2011
35
Pedunculated clear cell acanthoma. Report of a case with dermoscopic observation. ( 19889591 )
2010
36
Multiple reddish weeping nodules on the genital area of a girl. Giant clear cell acanthoma (CCA). ( 20500186 )
2010
37
Clear cell acanthoma: a rare clinical diagnosis prior to biopsy. ( 20931670 )
2010
38
Multiple eruptive clear cell acanthoma. ( 21886743 )
2010
39
A case of polypoid clear cell acanthoma on the nipple. ( 20711275 )
2010
40
Comparing in vivo reflectance confocal microscopy, dermoscopy, and histology of clear-cell acanthoma. ( 19397663 )
2009
41
Clear cell acanthoma: new observations on dermatoscopy. ( 18583817 )
2008
42
A glistening brown nodule. Pigmented clear cell acanthoma. ( 17310007 )
2007
43
Urachal duct remnant-like umbilical clear cell acanthoma in an infant: an unusual presentation and pitfall in clinical practice. ( 17550563 )
2007
44
Clear-cell acanthoma versus acanthosis: a psoriasiform reaction pattern lacking tricholemmal differentiation. ( 17667172 )
2007
45
Plaque form of warty dyskeratoma - acantholytic dyskeratotic acanthoma. ( 17518779 )
2007
46
Giant clear-cell acanthoma with keratoacanthoma-like changes: a case report. ( 17083866 )
2006
47
Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. ( 16984257 )
2006
48
Clear cell acanthoma occurring on the hallux: the first case report. ( 16987281 )
2006
49
Clear cell acanthoma successfully treated with a carbon dioxide laser. ( 16188196 )
2005
50
Clear cell acanthoma occurring in a split-thickness skin graft. ( 16327592 )
2005

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CALM1 CALM2 CALM3 CD68 FGF10 FGF7
2
Show member pathways
13.71 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
3
Show member pathways
13.53 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
4
Show member pathways
13.47 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
5
Show member pathways
13.44 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
6
Show member pathways
13.42 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
7
Show member pathways
13.28 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
8
Show member pathways
13.28 CALM1 CALM2 CALM3 CEACAM5 GATA3 IFNA1
9
Show member pathways
13.27 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
10
Show member pathways
13.26 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
11
Show member pathways
13.26 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
12
Show member pathways
13.04 FGF10 FGF7 FGFR2 IL2RA KITLG NGFR
13
Show member pathways
12.97 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
14
Show member pathways
12.95 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
15
Show member pathways
12.86 CALM1 CALM2 CALM3 IFNA1 IL2RA
16 12.76 FGF10 FGF7 FGFR2 KITLG NGFR
17
Show member pathways
12.76 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
18
Show member pathways
12.68 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
19
Show member pathways
12.57 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
20 12.54 CEACAM5 GATA3 HAVCR1 IFNA1 IL2RA KITLG
21 12.53 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
22
Show member pathways
12.5 CALM1 CALM2 CALM3 IFNA1
23
Show member pathways
12.48 CALM1 CALM2 CALM3 GATA3
24
Show member pathways
12.48 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
25
Show member pathways
12.42 CALM1 CALM2 CALM3 KITLG
26
Show member pathways
12.38 CALM1 CALM2 CALM3 IL2RA
27
Show member pathways
12.29 CALM1 CALM2 CALM3 FGF10 FGF7 FGFR2
28 12.23 CALM1 CALM2 CALM3 IFNA1
29
Show member pathways
12.19 FGF10 FGF7 FGFR2 IFNA1 IL2RA KITLG
30 12.08 FGF10 FGF7 KITLG NGFR
31
Show member pathways
12 CALM1 CALM2 CALM3
32 11.99 CD68 CEACAM5 IL2RA KITLG
33
Show member pathways
11.98 CALM1 CALM2 CALM3
34
Show member pathways
11.96 CALM1 CALM2 CALM3
35
Show member pathways
11.93 CALM1 CALM2 CALM3
36 11.92 CALM1 CALM2 CALM3
37 11.91 CALM1 CALM2 CALM3
38 11.88 CALM1 CALM2 CALM3
39
Show member pathways
11.88 CALM1 CALM2 CALM3
40
Show member pathways
11.86 CALM1 CALM2 CALM3
41
Show member pathways
11.85 CALM1 CALM2 CALM3
42
Show member pathways
11.78 CALM1 CALM2 CALM3
43
Show member pathways
11.77 CALM1 CALM2 CALM3
44 11.76 CALM1 CALM2 CALM3
45
Show member pathways
11.76 CALM1 CALM2 CALM3 GATA3 IL2RA
46
Show member pathways
11.75 CALM1 CALM2 CALM3
47 11.74 CALM1 CALM2 CALM3
48 11.72 FGF10 FGF7 FGFR2 KITLG
49
Show member pathways
11.7 CALM1 CALM2 CALM3 IL2RA
50 11.68 CALM1 CALM2 CALM3

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.72 CEACAM5 FGF10 FGFR2 IL2RA NGFR
2 spindle pole GO:0000922 9.61 CALM1 CALM2 CALM3
3 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
4 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
5 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
6 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3
7 plasma membrane GO:0005886 10.11 CALM1 CALM2 CALM3 CD68 CEACAM5 FGF10
8 extracellular region GO:0005576 10.01 CALM1 CEACAM5 FGF10 FGF7 FGFR2 IFNA1

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol phosphorylation GO:0046854 9.92 FGF10 FGF7 FGFR2 KITLG
2 animal organ morphogenesis GO:0009887 9.9 FGF10 FGFR2 GATA3
3 lung development GO:0030324 9.89 FGF10 FGFR2 PDPN
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 FGF10 FGF7 KITLG
5 calcium-mediated signaling GO:0019722 9.87 CALM1 CALM2 CALM3
6 fibroblast growth factor receptor signaling pathway GO:0008543 9.86 FGF10 FGF7 FGFR2
7 inner ear morphogenesis GO:0042472 9.86 FGF10 FGFR2 GATA3
8 response to calcium ion GO:0051592 9.86 CALM1 CALM2 CALM3
9 positive regulation of epithelial cell proliferation GO:0050679 9.84 FGF10 FGF7 FGFR2
10 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.83 FGF10 FGF7 FGFR2
11 positive regulation of protein kinase B signaling GO:0051897 9.83 FGF10 FGF7 FGFR2 GATA3 KITLG
12 positive regulation of protein serine/threonine kinase activity GO:0071902 9.82 CALM1 CALM2 CALM3
13 substantia nigra development GO:0021762 9.82 CALM1 CALM2 CALM3
14 regulation of cytokinesis GO:0032465 9.81 CALM1 CALM2 CALM3
15 regulation of heart rate GO:0002027 9.8 CALM1 CALM2 CALM3
16 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.8 CALM1 CALM2 CALM3
17 hair follicle morphogenesis GO:0031069 9.74 FGF10 FGF7 FGFR2
18 embryonic pattern specification GO:0009880 9.73 FGF10 FGFR2
19 positive regulation of Ras protein signal transduction GO:0046579 9.73 FGF10 KITLG
20 positive regulation of T cell differentiation GO:0045582 9.73 GATA3 IL2RA
21 protein localization to cell surface GO:0034394 9.73 FGF10 FGF7
22 positive regulation of protein dephosphorylation GO:0035307 9.73 CALM1 CALM2 CALM3
23 response to corticosterone GO:0051412 9.72 CALM1 CALM3
24 embryonic digestive tract morphogenesis GO:0048557 9.72 FGF10 FGFR2
25 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.72 CALM1 CALM3
26 embryonic hemopoiesis GO:0035162 9.72 GATA3 KITLG
27 positive regulation of protein autophosphorylation GO:0031954 9.72 CALM1 CALM2 CALM3
28 mesonephros development GO:0001823 9.71 FGF10 GATA3
29 organ growth GO:0035265 9.71 FGF10 FGFR2
30 positive regulation of keratinocyte migration GO:0051549 9.71 FGF10 FGF7
31 regulation of synaptic vesicle endocytosis GO:1900242 9.71 CALM1 CALM3
32 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.71 CALM1 CALM2 CALM3
33 establishment of protein localization to membrane GO:0090150 9.7 CALM1 CALM3
34 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.7 CALM1 CALM2 CALM3
35 limb bud formation GO:0060174 9.69 FGF10 FGFR2
36 positive regulation of keratinocyte proliferation GO:0010838 9.69 FGF10 FGF7
37 regulation of cardiac muscle contraction GO:0055117 9.69 CALM1 CALM2 CALM3
38 bud elongation involved in lung branching GO:0060449 9.68 FGF10 FGFR2
39 lacrimal gland development GO:0032808 9.68 FGF10 FGFR2
40 otic vesicle formation GO:0030916 9.67 FGF10 FGFR2
41 regulation of high voltage-gated calcium channel activity GO:1901841 9.67 CALM1 CALM3
42 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.67 CALM1 CALM2 CALM3
43 epidermis morphogenesis GO:0048730 9.66 FGF10 FGFR2
44 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.66 FGF7 FGFR2
45 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.65 FGF10 FGFR2
46 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.65 CALM1 CALM2 CALM3
47 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.64 FGF10 FGF7
48 detection of calcium ion GO:0005513 9.63 CALM1 CALM2 CALM3
49 MAPK cascade GO:0000165 9.63 CALM1 FGF10 FGF7 FGFR2 IL2RA KITLG
50 branch elongation involved in salivary gland morphogenesis GO:0060667 9.61 FGF10 FGFR2

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.72 CALM1 CALM2 CALM3
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.71 FGF10 FGF7 FGFR2 KITLG
3 1-phosphatidylinositol-3-kinase activity GO:0016303 9.67 FGF10 FGF7 FGFR2
4 disordered domain specific binding GO:0097718 9.65 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.63 CALM1 CALM2 CALM3
6 nitric-oxide synthase binding GO:0050998 9.54 CALM1 CALM3
7 titin binding GO:0031432 9.54 CALM1 CALM2 CALM3
8 calcium channel inhibitor activity GO:0019855 9.52 CALM1 CALM2
9 nitric-oxide synthase regulator activity GO:0030235 9.51 CALM1 CALM3
10 adenylate cyclase binding GO:0008179 9.5 CALM1 CALM2 CALM3
11 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
12 protein phosphatase activator activity GO:0072542 9.43 CALM1 CALM2 CALM3
13 adenylate cyclase activator activity GO:0010856 9.33 CALM1 CALM2 CALM3
14 N-terminal myristoylation domain binding GO:0031997 9.13 CALM1 CALM2 CALM3
15 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.1 CALM1 FGF10 FGF7 FGFR2 IL2RA KITLG

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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