MCID: CLR001
MIFTS: 31

Clear Cell Acanthoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Acanthoma

MalaCards integrated aliases for Clear Cell Acanthoma:

Name: Clear Cell Acanthoma 12 15
Acanthoma 44 72
Acanthoma, Clear Cell 72
Pale Acanthoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:172
MeSH 44 D049309
NCIt 50 C97041
SNOMED-CT 68 65540008
UMLS 72 C0333992 C0846967

Summaries for Clear Cell Acanthoma

MalaCards based summary : Clear Cell Acanthoma, also known as acanthoma, is related to acanthoma and epidermolytic hyperkeratosis. An important gene associated with Clear Cell Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways is Developmental Biology. Affiliated tissues include skin, ovary and prostate.

Wikipedia : 75 Clear cell acanthoma (also known as "Acanthome cellules claires of Degos and Civatte," "Degos... more...

Related Diseases for Clear Cell Acanthoma

Diseases in the Clear Cell Acanthoma family:

Large Cell Acanthoma

Diseases related to Clear Cell Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 acanthoma 30.8 KRT10 FGFR2 FGF10
2 epidermolytic hyperkeratosis 30.3 KRT10 FLG
3 keratosis 29.8 KRT10 FLG
4 lichen planus 29.7 KRT10 FLG
5 discoid lupus erythematosus 29.6 KRT10 FLG
6 keratoacanthoma 29.6 KRT10 FLG
7 papilloma 29.5 KRT10 FLG
8 palmoplantar keratoderma, epidermolytic 29.4 KRT10 FLG
9 autosomal recessive congenital ichthyosis 29.2 KRT10 FLG
10 pilar sheath acanthoma 12.6
11 epidermolytic acanthoma 12.6
12 large cell acanthoma 12.6
13 acantholytic acanthoma 12.4
14 onychocytic matricoma 11.7
15 erythrokeratoderma ''en cocardes'' 10.6
16 autosomal dominant epidermolytic ichthyosis 10.6
17 psoriasis 10.5
18 pustulosis of palm and sole 10.5
19 lentigines 10.4
20 actinic keratosis 10.4
21 keratosis, seborrheic 10.3
22 ichthyosis 10.3
23 dermatitis 10.3
24 inverted follicular keratosis 10.3
25 posttransplant acute limbic encephalitis 10.3
26 muir-torre syndrome 10.3
27 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
28 basal cell carcinoma 10.2
29 adenoma 10.2
30 nevus, epidermal 10.2
31 dowling-degos disease 1 10.2
32 varicose veins 10.2
33 dermatitis, atopic 10.2
34 epidermodysplasia verruciformis 1 10.2
35 porokeratosis 10.2
36 skin carcinoma 10.1
37 molluscum contagiosum 10.1
38 bowenoid papulosis 10.1
39 trichofolliculoma 10.1
40 warty dyskeratoma 10.1
41 pemphigus vegetans 10.1
42 renal cell carcinoma, nonpapillary 10.1
43 squamous cell papilloma 10.1
44 squamous cell carcinoma 10.1
45 cystadenoma 10.1
46 epidermolysis bullosa 10.1
47 mammary paget's disease 10.1
48 skin disease 10.1
49 hidrocystoma 10.1
50 epidermolysis bullosa acquisita 10.1

Graphical network of the top 20 diseases related to Clear Cell Acanthoma:



Diseases related to Clear Cell Acanthoma

Symptoms & Phenotypes for Clear Cell Acanthoma

Drugs & Therapeutics for Clear Cell Acanthoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Acanthoma

Cochrane evidence based reviews: acanthoma

Genetic Tests for Clear Cell Acanthoma

Anatomical Context for Clear Cell Acanthoma

MalaCards organs/tissues related to Clear Cell Acanthoma:

41
Skin, Ovary, Prostate, Uterus, Cervix, Colon, Liver

Publications for Clear Cell Acanthoma

Articles related to Clear Cell Acanthoma:

(show top 50) (show all 411)
# Title Authors PMID Year
1
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 38
31436573 2019
2
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. 38
30659646 2019
3
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 38
30203987 2019
4
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 38
30940575 2019
5
Pale (Clear) Cell Acanthoma of the Palate. 38
31230231 2019
6
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 38
30663082 2019
7
Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient. 38
31046909 2019
8
Onychocytic matricoma. 38
31090828 2019
9
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 38
31078506 2019
10
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. 38
30558902 2019
11
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 38
30839347 2019
12
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. 38
30604543 2019
13
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 38
30480645 2018
14
Clear Cell Acanthoma with Atypical Location -Case Report and Literature Review. 38
31123619 2018
15
Longitudinal subungual acanthoma: one denomination for various clinical presentations. 38
29705997 2018
16
Clear Cell Acanthoma on the Areola. 38
30261576 2018
17
Giant clear cell acanthoma with dermatoscopic white lines. 38
30116672 2018
18
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 38
29633447 2018
19
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. 38
29735169 2018
20
Dermoscopic features of clear cell acanthoma. 38
29924237 2018
21
Multiple Eruptive Clear Cell Acanthoma. 38
29692468 2018
22
Case of podoplanin-positive clear cell acanthoma. 38
28266032 2018
23
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. 38
28609346 2018
24
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. 38
28857272 2018
25
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 38
29090469 2018
26
Familial seborrhoeic keratosis associated with multiple 'pure reticulated acanthomas' and infundibulocystic basal cell carcinomas. 38
28627087 2017
27
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. 38
28426905 2017
28
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. 38
28470879 2017
29
Germinotropic Onychocytic Matricoma: A New Histopathologic Subtype of Onychocytic Matricoma in the Light of the Microanatomy of the Normal Nail Unit, With Special Reference to Nail Mesenchyme. 38
28169867 2017
30
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. 38
29085717 2017
31
Reticulated acanthoma with sebaceous differentiation. 38
28492170 2017
32
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. 38
28868008 2017
33
[Multiple epidermolytic acanthomas of the genitalia]. 38
27789051 2017
34
Acanthoma Fissuratum: Lest we Forget. 38
28405560 2017
35
Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome - a case report. 38
27682856 2017
36
"String of pearls pattern": report of three cases of non clear-cell acanthoma. 38
29267474 2017
37
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. 38
29267438 2017
38
Clear Cell Acanthoma of the Areola and Nipple. 38
27206609 2016
39
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. 38
27814733 2016
40
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. 38
26945829 2016
41
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 38
27153339 2016
42
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 38
25186214 2016
43
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. 38
26885606 2016
44
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 38
27648388 2016
45
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. 38
27185430 2016
46
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 38
27034569 2016
47
Multiple pigmented clear cell acanthoma in an African patient. 38
25414053 2016
48
Clear cell acanthoma on the dorsum of the hand. 38
25353276 2016
49
[Anatomoclinical study of large-cell acanthoma]. 38
26651924 2016
50
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. 38
26825163 2016

Variations for Clear Cell Acanthoma

Expression for Clear Cell Acanthoma

Search GEO for disease gene expression data for Clear Cell Acanthoma.

Pathways for Clear Cell Acanthoma

Pathways related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.14 KRT10 FLG FGFR2 FGF10

GO Terms for Clear Cell Acanthoma

Cellular components related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 KRT10 FLG

Biological processes related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of MAPK cascade GO:0043410 9.65 FGFR2 FGF10
2 animal organ morphogenesis GO:0009887 9.65 FGFR2 FGF10
3 cornification GO:0070268 9.64 KRT10 FLG
4 wound healing GO:0042060 9.64 FGFR2 FGF10
5 lung development GO:0030324 9.63 FGFR2 FGF10
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.63 FGFR2 FGF10
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.62 FGFR2 FGF10
8 keratinocyte differentiation GO:0030216 9.62 KRT10 FLG
9 epithelial cell differentiation GO:0030855 9.61 FGFR2 FGF10
10 inner ear morphogenesis GO:0042472 9.61 FGFR2 FGF10
11 positive regulation of epithelial cell proliferation GO:0050679 9.6 FGFR2 FGF10
12 peptide cross-linking GO:0018149 9.59 KRT10 FLG
13 positive regulation of Wnt signaling pathway GO:0030177 9.58 FGFR2 FGF10
14 lung alveolus development GO:0048286 9.58 FGFR2 FGF10
15 digestive tract development GO:0048565 9.57 FGFR2 FGF10
16 hair follicle morphogenesis GO:0031069 9.56 FGFR2 FGF10
17 regulation of smoothened signaling pathway GO:0008589 9.55 FGFR2 FGF10
18 embryonic pattern specification GO:0009880 9.54 FGFR2 FGF10
19 embryonic digestive tract morphogenesis GO:0048557 9.52 FGFR2 FGF10
20 organ growth GO:0035265 9.51 FGFR2 FGF10
21 branching involved in salivary gland morphogenesis GO:0060445 9.49 FGFR2 FGF10
22 limb bud formation GO:0060174 9.48 FGFR2 FGF10
23 otic vesicle formation GO:0030916 9.46 FGFR2 FGF10
24 lacrimal gland development GO:0032808 9.43 FGFR2 FGF10
25 bud elongation involved in lung branching GO:0060449 9.4 FGFR2 FGF10
26 epidermis morphogenesis GO:0048730 9.37 FGFR2 FGF10
27 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.32 FGFR2 FGF10
28 mesenchymal cell differentiation involved in lung development GO:0060915 9.26 FGFR2 FGF10
29 mammary gland bud formation GO:0060615 9.16 FGFR2 FGF10
30 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 8.96 FGFR2 FGF10
31 branch elongation involved in salivary gland morphogenesis GO:0060667 8.62 FGFR2 FGF10

Molecular functions related to Clear Cell Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of epidermis GO:0030280 8.62 KRT10 FLG

Sources for Clear Cell Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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