MCID: CLR137
MIFTS: 31

Clear Cell Adenocarcinoma of the Ovary

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Clear Cell Adenocarcinoma of the Ovary

MalaCards integrated aliases for Clear Cell Adenocarcinoma of the Ovary:

Name: Clear Cell Adenocarcinoma of the Ovary 58
Ovarian Clear Cell Adenocarcinoma 58 70

Classifications:

Orphanet: 58  
Rare gynaecological and obstetric diseases


External Ids:

ICD10 via Orphanet 33 C56
Orphanet 58 ORPHA398971
UMLS 70 C1518693

Summaries for Clear Cell Adenocarcinoma of the Ovary

MalaCards based summary : Clear Cell Adenocarcinoma of the Ovary, also known as ovarian clear cell adenocarcinoma, is related to ovarian clear cell carcinoma and clear cell adenocarcinoma. An important gene associated with Clear Cell Adenocarcinoma of the Ovary is POU6F1 (POU Class 6 Homeobox 1), and among its related pathways/superpathways are Small cell lung cancer and Androgen receptor signaling pathway. The drugs Sunitinib and Durvalumab have been mentioned in the context of this disorder. Affiliated tissues include ovary, eye and spleen.

Related Diseases for Clear Cell Adenocarcinoma of the Ovary

Diseases related to Clear Cell Adenocarcinoma of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell carcinoma 30.1 GPC3 CCNE1
2 clear cell adenocarcinoma 10.9
3 adenocarcinoma 10.6
4 ovarian clear cell adenocarcinoma 10.6
5 mucinous adenocarcinoma 10.5
6 appendix adenocarcinoma 10.5
7 endometriosis 10.5
8 serous cystadenocarcinoma 10.4
9 adenofibroma 10.4
10 clear cell adenofibroma 10.4
11 ovarian serous carcinoma 10.3
12 cystadenocarcinoma 10.3
13 hypoxia 10.3
14 renal cell carcinoma, nonpapillary 10.2
15 47,xyy 10.2
16 malignant epithelial tumor of ovary 10.2
17 enterocolitis 10.1
18 small cell carcinoma 10.1
19 endometriosis of ovary 10.1
20 neutropenia 10.1
21 endodermal sinus tumor 10.1
22 constipation 10.1
23 ovarian brenner tumor 10.1
24 ovary adenocarcinoma 10.1
25 testicular yolk sac tumor 10.1
26 ovarian small cell carcinoma 10.1
27 small-cell carcinoma of the ovary of hypercalcemic type 10.1
28 peritonitis 10.1
29 ovarian epithelial cancer 10.1
30 bowenoid papulosis 10.0 CCNE1 CCND1
31 hypercalcemia, infantile, 1 10.0
32 polycystic liver disease 1 with or without kidney cysts 10.0
33 retinoblastoma 10.0
34 endometrial cancer 10.0
35 lung cancer susceptibility 3 10.0
36 familial adenomatous polyposis 10.0
37 hereditary lymphedema i 10.0
38 combined immunodeficiency 10.0
39 interstitial nephritis 10.0
40 hemopericardium 10.0
41 pericardial effusion 10.0
42 sensory peripheral neuropathy 10.0
43 papillary adenocarcinoma 10.0
44 cellulitis 10.0
45 clear cell renal cell carcinoma 10.0
46 urinary tract obstruction 10.0
47 kidney disease 10.0
48 ovarian serous cystadenocarcinoma 10.0
49 ovarian clear cell adenofibroma 10.0
50 severe combined immunodeficiency 10.0

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma of the Ovary:



Diseases related to Clear Cell Adenocarcinoma of the Ovary

Symptoms & Phenotypes for Clear Cell Adenocarcinoma of the Ovary

Drugs & Therapeutics for Clear Cell Adenocarcinoma of the Ovary

Drugs for Clear Cell Adenocarcinoma of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2
Durvalumab Approved, Investigational Phase 2 1428935-60-7
3
Bevacizumab Approved, Investigational Phase 2 216974-75-3
4
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
5 Angiogenesis Inhibitors Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Antineoplastic Agents, Immunological Phase 2
8
Paclitaxel Approved, Vet_approved 33069-62-4 36314
9 Albumin-Bound Paclitaxel

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Evaluation of SU11248 (Sunitinib Malate) (NSC #736511) in the Treatment of Persistent or Recurrent Clear Cell Ovarian Carcinoma Completed NCT00979992 Phase 2 Sunitinib Malate
2 A Multicentre Phase II Randomised Trial of Durvalumab (MEDI4736) Versus Physician's Choice Chemotherapy in Recurrent Ovarian Clear Cell Adenocarcinomas (MOCCA) Recruiting NCT03405454 Phase 2 durvalumab;standard chemotherapy
3 Retrospective Multi-institutional Survey of Clinical Characteristics in Ovarian Clear Cell Adenocarcinoma Cancer Patients Completed NCT02129036

Search NIH Clinical Center for Clear Cell Adenocarcinoma of the Ovary

Genetic Tests for Clear Cell Adenocarcinoma of the Ovary

Anatomical Context for Clear Cell Adenocarcinoma of the Ovary

MalaCards organs/tissues related to Clear Cell Adenocarcinoma of the Ovary:

40
Ovary, Eye, Spleen, Cervix

Publications for Clear Cell Adenocarcinoma of the Ovary

Articles related to Clear Cell Adenocarcinoma of the Ovary:

(show top 50) (show all 177)
# Title Authors PMID Year
1
Noncanonical IL6 Signaling-Mediated Activation of YAP Regulates Cell Migration and Invasion in Ovarian Clear Cell Cancer. 61
32917727 2020
2
A multicenter phase II randomized trial of durvalumab (MEDI-4736) versus physician's choice chemotherapy in recurrent ovarian clear cell adenocarcinoma (MOCCA). 61
32591370 2020
3
Identification of Candidate Genes Associated with Susceptibility to Ovarian Clear Cell Adenocarcinoma Using cis-eQTL Analysis. 61
32316112 2020
4
Mixed Serous and Clear Cell Adenocarcinoma of the Ovary Presenting with Symptomatic Hypercalcemia: A Case Report and Clinical Considerations. 61
32069206 2020
5
Germline mutation and aberrant transcripts of WWOX in a syndrome with multiple primary tumors. 61
31056747 2019
6
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 61
29551085 2018
7
Synchronous occurrence of primary right ovarian endometrioid adenocarcinoma and primary left ovarian clear cell adenocarcinoma: A case report. 61
29979406 2018
8
Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review. 61
29933751 2018
9
Skin metastases in ovarian clear cell adenocarcinoma: a case report and a review of the literature. 61
29184869 2017
10
[Ovarian Cancer Rupture Causing Acute Abdomen That Required Emergency Surgery - A Case Report]. 61
28133347 2016
11
Vesical clear cell adenocarcinoma arising from endometriosis: A mullerian tumor, indistinguishable from ovarian clear cell adenocarcinoma. 61
27660815 2016
12
Rare and challenging case of stroke as a manifestation of non bacterial thrombotic endocarditis in an underlying ovarian clear cell carcinoma. 61
27833758 2016
13
Possible role of thymidine phosphorylase in gynecological tumors as an individualized treatment strategy. 61
27899985 2016
14
Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. 61
27699033 2016
15
Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary. 61
27541369 2016
16
Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle. 61
27120812 2016
17
ARID1A gene mutation in ovarian and endometrial cancers (Review). 61
26572704 2016
18
Combined benign Brenner tumor and clear cell adenocarcinoma of the ovary. 61
26150073 2016
19
Low Expression of S100P Is Associated With Poor Prognosis in Patients With Clear Cell Adenocarcinoma of the Ovary. 61
26397155 2015
20
The clinical characteristics and outcomes of cases with pure ovarian clear cell, mixed type and high-grade serous adenocarcinoma. 61
25855053 2015
21
Optimal cytoreductive surgery for underlying ovarian cancer associated with deep venous thrombosis without placement of inferior vena cava filter: A case report and literature review. 61
26622893 2015
22
Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice. 61
25398420 2015
23
[A Case of Pneumocystis Pneumonia during Chemotherapy for Recurrent Ovarian Cancer]. 61
26197755 2015
24
Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma. 61
25658832 2015
25
Napsin A is a specific marker for ovarian clear cell adenocarcinoma. 61
24721826 2015
26
Gene methylation profiles as prognostic markers in ovarian clear cell and endometrioid adenocarcinomas. 61
25755836 2015
27
Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report. 61
26082939 2014
28
Mass spectrometric analysis of the phosphorylation levels of the SWI/SNF chromatin remodeling/tumor suppressor proteins ARID1A and Brg1 in ovarian clear cell adenocarcinoma cell lines. 61
25083560 2014
29
[A case of platinum-resistant, recurrent ovarian clear cell adenocarcinoma successfully treated with irinotecan (CPT-11) and paclitaxel (PTX) chemotherapy]. 61
25434451 2014
30
Patterns of recurrence and role of pelvic radiotherapy in ovarian clear cell adenocarcinoma. 61
25275661 2014
31
A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. 61
24306200 2014
32
Impact of surgical staging in stage I clear cell adenocarcinoma of the ovary. 61
25010038 2014
33
Maximum standardized uptake value of fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in ovarian clear cell adenocarcinoma. 61
24987918 2014
34
Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. 61
24375438 2014
35
Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma simulating fetal gut in a postmenopausal woman. 61
24707459 2014
36
Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma. 61
24815386 2014
37
Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. 61
24669262 2014
38
Decreased ARID1A expression is correlated with chemoresistance in epithelial ovarian cancer. 61
24459582 2014
39
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. 61
24504419 2014
40
Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma. 61
23805888 2013
41
[A patient with recurrent ovarian clear cell adenocarcinoma and chronic kidney disease exhibited complete response to paclitaxel plus carboplatin]. 61
24196084 2013
42
Alterations of hypoxia-induced factor signaling pathway due to mammalian target of rapamycin (mTOR) suppression in ovarian clear cell adenocarcinoma: in vivo and in vitro explorations for clinical trial. 61
23899586 2013
43
Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene. 61
23430509 2013
44
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. 61
23726144 2013
45
A Case of Stage III c Ovarian Clear Cell Carcinoma: The Role for Predictive Biomarkers and Targeted Therapies. 61
23502469 2013
46
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. 61
23469222 2013
47
Stathmin Regulates Hypoxia-Inducible Factor-1α Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma. 61
23819061 2013
48
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. 61
24244679 2013
49
Clear cell adenocarcinoma of the ovary with a sarcoid reaction in the spleen and regional lymph nodes: A case report. 61
24371694 2013
50
Long-term survival in patients with clear cell adenocarcinoma of ovary treated with irinotecan hydrochloride plus cisplatin therapy as first-line chemotherapy. 61
22639843 2012

Variations for Clear Cell Adenocarcinoma of the Ovary

Expression for Clear Cell Adenocarcinoma of the Ovary

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma of the Ovary.

Pathways for Clear Cell Adenocarcinoma of the Ovary

Pathways related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.44 CCNE1 CCND1
2 11.42 CCNE1 CCND1
3 11.38 CCNE1 CCND1
4
Show member pathways
11.3 CCNE1 CCND1
5
Show member pathways
11.25 CCNE1 CCND1
6 11.03 CCNE1 CCND1
7 10.96 CCNE1 CCND1
8 10.8 CCNE1 CCND1
9 10.46 CCNE1 CCND1
10 9.88 NEU3 NEU1

GO Terms for Clear Cell Adenocarcinoma of the Ovary

Cellular components related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 9.16 NEU1 GPC3
2 lysosome GO:0005764 9.13 NEU3 NEU1 GPC3
3 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNE1 CCND1

Biological processes related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.56 POU6F1 IFI27 CCNE1 CCND1
2 G1/S transition of mitotic cell cycle GO:0000082 9.4 CCNE1 CCND1
3 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.37 CCNE1 CCND1
4 glycosphingolipid metabolic process GO:0006687 9.32 NEU3 NEU1
5 mitotic cell cycle phase transition GO:0044772 9.16 CCNE1 CCND1
6 oligosaccharide catabolic process GO:0009313 8.96 NEU3 NEU1
7 ganglioside catabolic process GO:0006689 8.62 NEU3 NEU1

Molecular functions related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.4 NEU3 NEU1
2 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 9.37 CCNE1 CCND1
3 exo-alpha-(2->8)-sialidase activity GO:0052796 9.32 NEU3 NEU1
4 exo-alpha-(2->6)-sialidase activity GO:0052795 9.26 NEU3 NEU1
5 exo-alpha-(2->3)-sialidase activity GO:0052794 9.16 NEU3 NEU1
6 exo-alpha-sialidase activity GO:0004308 8.96 NEU3 NEU1
7 alpha-sialidase activity GO:0016997 8.62 NEU3 NEU1

Sources for Clear Cell Adenocarcinoma of the Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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