MCID: CLR137
MIFTS: 30

Clear Cell Adenocarcinoma of the Ovary

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Clear Cell Adenocarcinoma of the Ovary

MalaCards integrated aliases for Clear Cell Adenocarcinoma of the Ovary:

Name: Clear Cell Adenocarcinoma of the Ovary 60
Ovarian Clear Cell Adenocarcinoma 60 74

Classifications:



External Ids:

ICD10 via Orphanet 35 C56
Orphanet 60 ORPHA398971
UMLS 74 C1518693

Summaries for Clear Cell Adenocarcinoma of the Ovary

MalaCards based summary : Clear Cell Adenocarcinoma of the Ovary, also known as ovarian clear cell adenocarcinoma, is related to ovarian clear cell adenocarcinoma and adenocarcinoma. An important gene associated with Clear Cell Adenocarcinoma of the Ovary is CCND1 (Cyclin D1), and among its related pathways/superpathways are Small cell lung cancer and Androgen receptor signaling pathway. Affiliated tissues include ovary, skin and spleen.

Related Diseases for Clear Cell Adenocarcinoma of the Ovary

Diseases related to Clear Cell Adenocarcinoma of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell adenocarcinoma 12.7
2 adenocarcinoma 10.7
3 clear cell adenocarcinoma 10.7
4 hypoxia 10.2
5 adenofibroma 10.2
6 endometriosis 10.2
7 ovarian cancer 10.0
8 ovarian cancer 1 10.0
9 clear cell adenofibroma 10.0
10 peritonitis 10.0
11 bowenoid papulosis 10.0 CCND1 CCNE1
12 renal cell carcinoma, nonpapillary 10.0
13 disorganization, mouse, homolog of 10.0
14 mucinous adenocarcinoma 10.0
15 appendix adenocarcinoma 10.0
16 urinary tract obstruction 10.0
17 gastrointestinal system cancer 9.9 CCND1 GPC3
18 galactosialidosis 9.8 NEU1 NEU3
19 endocrine gland cancer 9.7 CCND1 GPC3

Graphical network of the top 20 diseases related to Clear Cell Adenocarcinoma of the Ovary:



Diseases related to Clear Cell Adenocarcinoma of the Ovary

Symptoms & Phenotypes for Clear Cell Adenocarcinoma of the Ovary

Drugs & Therapeutics for Clear Cell Adenocarcinoma of the Ovary

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenocarcinoma of the Ovary

Genetic Tests for Clear Cell Adenocarcinoma of the Ovary

Anatomical Context for Clear Cell Adenocarcinoma of the Ovary

MalaCards organs/tissues related to Clear Cell Adenocarcinoma of the Ovary:

42
Ovary, Skin, Spleen, Lymph Node, Appendix

Publications for Clear Cell Adenocarcinoma of the Ovary

Articles related to Clear Cell Adenocarcinoma of the Ovary:

(show top 50) (show all 110)
# Title Authors Year
1
Synchronous occurrence of primary right ovarian endometrioid adenocarcinoma and primary left ovarian clear cell adenocarcinoma: A case report. ( 29979406 )
2018
2
Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma with fetal gut differentiation: a rare case report and literature review. ( 29933751 )
2018
3
Skin metastases in ovarian clear cell adenocarcinoma: a case report and a review of the literature. ( 29184869 )
2017
4
Combined benign Brenner tumor and clear cell adenocarcinoma of the ovary. ( 26150073 )
2016
5
Vesical clear cell adenocarcinoma arising from endometriosis: A mullerian tumor, indistinguishable from ovarian clear cell adenocarcinoma. ( 27660815 )
2016
6
Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. ( 27699033 )
2016
7
Napsin A is a specific marker for ovarian clear cell adenocarcinoma. ( 24721826 )
2015
8
Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice. ( 25398420 )
2015
9
Somatic copy number alterations associated with Japanese or endometriosis in ovarian clear cell adenocarcinoma. ( 25658832 )
2015
10
Low Expression of S100P Is Associated With Poor Prognosis in Patients With Clear Cell Adenocarcinoma of the Ovary. ( 26397155 )
2015
11
Defect of tropomyosin-related kinase B isotype expression in ovarian clear cell adenocarcinoma. ( 24815386 )
2014
12
Maximum standardized uptake value of fluorodeoxyglucose positron emission tomography/computed tomography is a prognostic factor in ovarian clear cell adenocarcinoma. ( 24987918 )
2014
13
Impact of surgical staging in stage I clear cell adenocarcinoma of the ovary. ( 25010038 )
2014
14
Mass spectrometric analysis of the phosphorylation levels of the SWI/SNF chromatin remodeling/tumor suppressor proteins ARID1A and Brg1 in ovarian clear cell adenocarcinoma cell lines. ( 25083560 )
2014
15
Patterns of recurrence and role of pelvic radiotherapy in ovarian clear cell adenocarcinoma. ( 25275661 )
2014
16
Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report. ( 26082939 )
2014
17
A recurrence-predicting prognostic factor for patients with ovarian clear-cell adenocarcinoma at reproductive age. ( 24306200 )
2014
18
Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation. ( 24375438 )
2014
19
Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423. ( 24504419 )
2014
20
Splenic metastasis of ovarian clear cell adenocarcinoma: A case report and review of the literature. ( 24669262 )
2014
21
Alpha-fetoprotein-producing ovarian clear cell adenocarcinoma simulating fetal gut in a postmenopausal woman. ( 24707459 )
2014
22
Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene. ( 23430509 )
2013
23
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. ( 23469222 )
2013
24
Integrative analysis of copy number alteration and gene expression profiling in ovarian clear cell adenocarcinoma. ( 23726144 )
2013
25
Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma. ( 23805888 )
2013
26
Stathmin Regulates Hypoxia-Inducible Factor-1α Expression through the Mammalian Target of Rapamycin Pathway in Ovarian Clear Cell Adenocarcinoma. ( 23819061 )
2013
27
Alterations of hypoxia-induced factor signaling pathway due to mammalian target of rapamycin (mTOR) suppression in ovarian clear cell adenocarcinoma: in vivo and in vitro explorations for clinical trial. ( 23899586 )
2013
28
Annexin A4 is involved in proliferation, chemo-resistance and migration and invasion in ovarian clear cell adenocarcinoma cells. ( 24244679 )
2013
29
Clear cell adenocarcinoma of the ovary with a sarcoid reaction in the spleen and regional lymph nodes: A case report. ( 24371694 )
2013
30
Clear cell adenocarcinoma of the ovary arising in atypical endometriosis: a report of eight cases. ( 21594603 )
2012
31
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. ( 22120431 )
2012
32
Histological grading of ovarian clear cell adenocarcinoma: proposal for a simple and reproducible grouping system based on tumor growth architecture. ( 22317866 )
2012
33
Two cases of ovarian clear cell adenocarcinoma producing estradiol. ( 22360511 )
2012
34
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. ( 22498943 )
2012
35
Promoter methylation status of HIN-1 associated with outcomes of ovarian clear cell adenocarcinoma. ( 22871047 )
2012
36
Nedaplatin and irinotecan combination therapy is equally effective and less toxic than cisplatin and irinotecan for patients with primary clear cell adenocarcinoma of the ovary and recurrent ovarian carcinoma. ( 23162643 )
2012
37
[DNA damage response in ovarian clear cell adenocarcinoma]. ( 22812231 )
2012
38
Validation of the histologic grading for ovarian clear cell adenocarcinoma: a retrospective multi-institutional study by the Japan Clear Cell Carcinoma Study Group. ( 21293288 )
2011
39
Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma. ( 21348943 )
2011
40
IGFBP-1 is expressed specifically in ovarian clear cell adenocarcinoma. ( 21457161 )
2011
41
Gene amplification and protein overexpression of MET are common events in ovarian clear-cell adenocarcinoma: their roles in tumor progression and prognostication of the patient. ( 21478826 )
2011
42
Analysis of mTOR inhibition-involved pathway in ovarian clear cell adenocarcinoma. ( 21614172 )
2011
43
PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma. ( 21735444 )
2011
44
Clear cell adenocarcinoma with a component of poorly differentiated histology: a poor prognostic subgroup of ovarian clear cell adenocarcinoma. ( 21804390 )
2011
45
Re-expression of estrogen receptor β inhibits the proliferation and migration of ovarian clear cell adenocarcinoma cells. ( 21874257 )
2011
46
Biological significance of plasminogen activator inhibitor-1 expression in ovarian clear cell adenocarcinoma. ( 22335020 )
2011
47
Transcription factor POU6F1 is important for proliferation of clear cell adenocarcinoma of the ovary and is a potential new molecular target. ( 20134265 )
2010
48
Randomized phase II trial of paclitaxel plus carboplatin therapy versus irinotecan plus cisplatin therapy as first-line chemotherapy for clear cell adenocarcinoma of the ovary: a JGOG study. ( 20169667 )
2010
49
Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma. ( 20486992 )
2010
50
Cumulative alterations of p27-related cell-cycle regulators in the development of endometriosis-associated ovarian clear cell adenocarcinoma. ( 20546339 )
2010

Variations for Clear Cell Adenocarcinoma of the Ovary

Expression for Clear Cell Adenocarcinoma of the Ovary

Search GEO for disease gene expression data for Clear Cell Adenocarcinoma of the Ovary.

Pathways for Clear Cell Adenocarcinoma of the Ovary

GO Terms for Clear Cell Adenocarcinoma of the Ovary

Cellular components related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.96 GPC3 NEU1
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCND1 CCNE1

Biological processes related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.46 CCND1 CCNE1 IFI27 POU6F1
2 G1/S transition of mitotic cell cycle GO:0000082 9.43 CCND1 CCNE1
3 positive regulation of cell cycle GO:0045787 9.4 CCND1 CCNE1
4 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.37 CCND1 CCNE1
5 regulation of mitotic nuclear division GO:0007088 9.32 CCND1 CCNE1
6 glycosphingolipid metabolic process GO:0006687 9.26 NEU1 NEU3
7 oligosaccharide catabolic process GO:0009313 8.96 NEU1 NEU3
8 ganglioside catabolic process GO:0006689 8.62 NEU1 NEU3

Molecular functions related to Clear Cell Adenocarcinoma of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, acting on glycosyl bonds GO:0016798 9.4 NEU1 NEU3
2 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 9.37 CCND1 CCNE1
3 exo-alpha-sialidase activity GO:0004308 9.32 NEU1 NEU3
4 exo-alpha-(2->3)-sialidase activity GO:0052794 9.26 NEU1 NEU3
5 exo-alpha-(2->6)-sialidase activity GO:0052795 9.16 NEU1 NEU3
6 exo-alpha-(2->8)-sialidase activity GO:0052796 8.96 NEU1 NEU3
7 alpha-sialidase activity GO:0016997 8.62 NEU1 NEU3

Sources for Clear Cell Adenocarcinoma of the Ovary

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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