MCID: CLR012
MIFTS: 37

Clear Cell Adenofibroma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma 12 15
Cystadenofibroma 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5477
MeSH 45 D062625
NCIt 51 C8985 C8987
SNOMED-CT 69 2962009 58161009
UMLS 74 C0334317

Summaries for Clear Cell Adenofibroma

Disease Ontology : 12 An adenofibroma that is characterized by the presence of cells with clear cytoplasm.

MalaCards based summary : Clear Cell Adenofibroma, also known as cystadenofibroma, is related to clear cell cystadenofibroma and cystadenofibroma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Phospholipase-C Pathway. Affiliated tissues include ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 clear cell cystadenofibroma 33.8 CALB2 TP53
2 cystadenofibroma 33.5 BRCA2 CALB2 KRT7
3 ovarian clear cell carcinoma 30.1 ARID1A KRT7 PIK3CA TP53
4 ovarian clear cell adenofibroma 12.5
5 mucinous cystadenofibroma 12.5
6 ovarian serous cystadenofibroma 12.2
7 ovarian mucinous cystadenofibroma 12.2
8 rete ovarii cystadenofibroma 12.1
9 ovarian endometrioid cystadenofibroma 12.1
10 fallopian tube cystadenofibroma 12.1
11 ovarian clear cell cystadenofibroma 11.3
12 adenofibroma 10.6
13 lung adenoid cystic carcinoma 10.3 PDGFRA PIK3CA
14 dermatosis papulosa nigra 10.3 MTOR PIK3CA
15 ceruminoma 10.3 KRT7 SLC2A1
16 renal pelvis adenocarcinoma 10.3 KRT7 SLC2A1
17 endometriosis 10.3
18 adenocarcinoma 10.3
19 clear cell adenocarcinoma 10.3
20 adult hepatocellular carcinoma 10.3 PIK3CA TP53
21 rare adenocarcinoma of the breast 10.3 PIK3CA TP53
22 spiradenoma 10.3 KRT7 TP53
23 splenic diffuse red pulp small b-cell lymphoma 10.3 CCNA2 TP53
24 uterine corpus serous adenocarcinoma 10.3 PIK3CA TP53
25 large intestine adenocarcinoma 10.3 KRT7 MTOR
26 atrophy of prostate 10.3 SLC2A1 TP53
27 large cell acanthoma 10.2 KRT7 MTOR
28 breast squamous cell carcinoma 10.2 PIK3CA TP53
29 mixed glioma 10.2 PDGFRA TP53
30 brain stem cancer 10.2 PDGFB TP53
31 vulvar intraepithelial neoplasia 10.2 KRT7 TP53
32 hidradenoma 10.2 KRT7 PIK3CA
33 ovarian clear cell adenocarcinoma 10.2 ARID1A MTOR PIK3CA
34 bladder carcinoma in situ 10.2 KRT7 TP53
35 anal squamous cell carcinoma 10.2 PIK3CA TP53
36 uterine body mixed cancer 10.2 ARID1A PIK3CA TP53
37 vulvar disease 10.2 KRT7 TP53
38 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.2 ARID1A PIK3CA TP53
39 papillary serous adenocarcinoma 10.2 KRT7 TP53
40 synchronous bilateral breast carcinoma 10.2 BRCA2 TP53
41 bile duct cystadenocarcinoma 10.2 CALB2 KRT7
42 nasal cavity adenocarcinoma 10.2 KRT7 TP53
43 malignant leydig cell tumor 10.2 CALB2 KRT7
44 fallopian tube adenocarcinoma 10.2 BRCA2 CALB2
45 brain stem glioma 10.2 PDGFB PIK3CA TP53
46 female reproductive endometrioid cancer 10.2 KRT7 TP53
47 renal pelvis carcinoma 10.1 KRT7 SLC2A1
48 inverted follicular keratosis 10.1 CALB2 MTOR
49 pancreatic neuroendocrine tumor 10.1 BRCA2 MTOR PIK3CA
50 malignant spiradenoma 10.1 KRT7 PIK3CA TP53

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:



Diseases related to Clear Cell Adenofibroma

Symptoms & Phenotypes for Clear Cell Adenofibroma

GenomeRNAi Phenotypes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.16 MTOR PIK3CA
2 Decreased viability GR00173-A 10.16 CKS1B PDGFRA SKP2
3 Decreased viability GR00221-A-1 10.16 MTOR PDGFRA PIK3CA
4 Decreased viability GR00221-A-2 10.16 CKS1B PIK3CA
5 Decreased viability GR00221-A-3 10.16 PDGFRA
6 Decreased viability GR00221-A-4 10.16 CKS1B MTOR PDGFRA PIK3CA
7 Decreased viability GR00301-A 10.16 SKP2
8 Decreased viability GR00342-S-1 10.16 MTOR
9 Decreased viability GR00342-S-2 10.16 MTOR
10 Decreased viability GR00402-S-2 10.16 CKS1B MTOR PDGFRA PIK3CA SKP2
11 Decreased viability in esophageal squamous lineage GR00235-A 9.23 ARID1A BRCA2 CALB2 KRT7 PDGFB PDGFRA

MGI Mouse Phenotypes related to Clear Cell Adenofibroma:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 ARID1A BRCA2 CCNA2 CKS1B KRT7 MTOR
2 growth/size/body region MP:0005378 10.25 ARID1A BRCA2 CKS1B MTOR PDGFA PDGFB
3 embryo MP:0005380 10.22 ARID1A BRCA2 CCNA2 MTOR PDGFA PDGFB
4 homeostasis/metabolism MP:0005376 10.22 ARID1A BRCA2 KRT7 MTOR PDGFA PDGFB
5 mortality/aging MP:0010768 10.17 ARID1A BRCA2 CCNA2 CKS1B MTOR PDGFA
6 immune system MP:0005387 10.16 ARID1A BRCA2 CCNA2 CKS1B MTOR PDGFB
7 hematopoietic system MP:0005397 10.15 ARID1A BRCA2 CCNA2 CKS1B MTOR PDGFB
8 nervous system MP:0003631 10.02 ARID1A BRCA2 CALB2 MTOR PDGFA PDGFB
9 muscle MP:0005369 9.95 ARID1A MTOR PDGFA PDGFB PDGFRA PIK3CA
10 neoplasm MP:0002006 9.85 ARID1A BRCA2 CKS1B PDGFRA PIK3CA TP53
11 no phenotypic analysis MP:0003012 9.8 ARID1A MTOR PDGFB PDGFRA PIK3CA SLC2A1
12 renal/urinary system MP:0005367 9.7 KRT7 MTOR PDGFA PDGFB PDGFRA SKP2
13 reproductive system MP:0005389 9.61 ARID1A BRCA2 CKS1B PDGFA PDGFB PDGFRA
14 skeleton MP:0005390 9.17 ARID1A BRCA2 MTOR PDGFA PDGFRA PIK3CA

Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

Genetic Tests for Clear Cell Adenofibroma

Anatomical Context for Clear Cell Adenofibroma

MalaCards organs/tissues related to Clear Cell Adenofibroma:

42
Ovary

Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(show all 18)
# Title Authors Year
1
Tumor-to-Tumor Metastasis of Colorectal Adenocarcinoma to Ovarian Cystadenofibroma: A Case Report and Review of the Literature. ( 30882401 )
2019
2
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. ( 29551085 )
2018
3
Serous cystadenofibroma misdiagnosed as an ovarian malignancy. ( 30567152 )
2018
4
Borderline Clear Cell Adenofibroma of the Ovary. ( 28465851 )
2017
5
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. ( 24172789 )
2013
6
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. ( 23153077 )
2013
7
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. ( 28861185 )
2012
8
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ( 22611972 )
2012
9
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. ( 21479128 )
2011
10
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. ( 20890073 )
2010
11
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. ( 19655165 )
2009
12
Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. ( 18600856 )
2008
13
Benign clear cell adenofibroma of the ovary. A case report with literature review. ( 17202822 )
2007
14
Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. ( 10645058 )
2000
15
Ovarian clear cell adenofibroma of borderline malignancy. A case report. ( 2793520 )
1989
16
Proliferating endometrioid cystadenofibroma of the ovary. Report of a case in a teenager. ( 7166119 )
1982
17
Papillary cystadenofibroma of endometrium: a histochemical and ultrastructural study. ( 1203842 )
1975
18
Malignant cystadenofibroma of the ovary: report of a case. ( 5771729 )
1969

Variations for Clear Cell Adenofibroma

Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 MTOR PDGFA PDGFB PDGFRA PIK3CA SKP2
2
Show member pathways
13 MTOR PDGFA PDGFB PDGFRA TP53
3
Show member pathways
12.89 CCNA2 MTOR PDGFB PDGFRA PIK3CA TP53
4
Show member pathways
12.86 BRCA2 PDGFA PDGFB PDGFRA TP53
5
Show member pathways
12.84 CCNA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
6
Show member pathways
12.7 ARID1A BRCA2 MTOR PIK3CA TP53
7
Show member pathways
12.69 BRCA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
8
Show member pathways
12.66 PDGFA PDGFB PDGFRA PIK3CA
9
Show member pathways
12.61 PDGFA PDGFB PDGFRA TP53
10
Show member pathways
12.59 MTOR PDGFA PDGFB PDGFRA PIK3CA TP53
11 12.57 PDGFA PDGFB PDGFRA PIK3CA
12
Show member pathways
12.51 CCNA2 CKS1B SKP2 TP53
13
Show member pathways
12.51 PDGFA PDGFB PDGFRA PIK3CA TP53
14
Show member pathways
12.49 MTOR PDGFB PIK3CA SLC2A1 TP53
15 12.46 BRCA2 CCNA2 SKP2 TP53
16
Show member pathways
12.42 MTOR PDGFRA PIK3CA SKP2 TP53
17
Show member pathways
12.4 MTOR PDGFRA PIK3CA TP53
18
Show member pathways
12.4 BRCA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
19
Show member pathways
12.39 CCNA2 MTOR PIK3CA TP53
20 12.39 MTOR PDGFA PDGFB PDGFRA PIK3CA TP53
21
Show member pathways
12.35 MTOR PDGFA PDGFB PDGFRA PIK3CA
22
Show member pathways
12.33 MTOR PDGFA PDGFB PDGFRA PIK3CA
23
Show member pathways
12.31 CCNA2 CKS1B SKP2 TP53
24
Show member pathways
12.3 MTOR PDGFA PDGFB PDGFRA PIK3CA
25 12.25 CCNA2 PIK3CA SKP2 TP53
26
Show member pathways
12.21 PDGFA PDGFB PDGFRA TP53
27
Show member pathways
12.17 MTOR PDGFRA PIK3CA TP53
28 12.14 PDGFA PDGFB PDGFRA PIK3CA SLC2A1 TP53
29 12.12 CCNA2 MTOR PIK3CA TP53
30
Show member pathways
12.11 MTOR PIK3CA TP53
31 12.09 BRCA2 MTOR TP53
32
Show member pathways
12.09 PDGFA PDGFB PDGFRA PIK3CA
33 12.08 MTOR PDGFRA PIK3CA TP53
34
Show member pathways
12.07 MTOR PIK3CA TP53
35 12.05 BRCA2 CKS1B MTOR PDGFA PDGFB PDGFRA
36 12.04 PDGFA PDGFB PIK3CA TP53
37
Show member pathways
12.02 MTOR PDGFA PDGFB PIK3CA
38 11.94 MTOR PIK3CA SLC2A1 TP53
39
Show member pathways
11.92 MTOR PIK3CA SLC2A1
40 11.87 PDGFA PDGFB PDGFRA
41 11.87 MTOR PIK3CA SLC2A1
42 11.81 CCNA2 SKP2 TP53
43 11.81 MTOR PDGFA PDGFB PDGFRA TP53
44 11.79 CKS1B PIK3CA SKP2 TP53
45
Show member pathways
11.71 CCNA2 MTOR TP53
46 11.69 PDGFA PDGFB PDGFRA SLC2A1
47
Show member pathways
11.67 CCNA2 MTOR PIK3CA
48 11.66 ARID1A PIK3CA TP53
49 11.6 CCNA2 SKP2 TP53
50 11.55 CCNA2 CKS1B SKP2

GO Terms for Clear Cell Adenofibroma

Cellular components related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 BRCA2 CALB2 CCNA2 KRT7 MTOR PDGFB
2 female pronucleus GO:0001939 8.62 CCNA2 SLC2A1

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.97 CKS1B MTOR PDGFRA PIK3CA SKP2
2 positive regulation of transcription, DNA-templated GO:0045893 9.89 ARID1A BRCA2 CCNA2 PDGFB TP53
3 positive regulation of MAPK cascade GO:0043410 9.77 PDGFA PDGFB PDGFRA
4 cell proliferation GO:0008283 9.77 BRCA2 SKP2 TP53
5 cellular response to hypoxia GO:0071456 9.76 CCNA2 MTOR TP53
6 wound healing GO:0042060 9.71 MTOR PDGFA PDGFRA
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.69 MTOR PDGFB TP53
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 PDGFA PDGFB PDGFRA
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.63 MTOR PDGFB SKP2
10 female gonad development GO:0008585 9.61 BRCA2 PDGFRA
11 positive regulation of protein autophosphorylation GO:0031954 9.61 PDGFA PDGFB
12 negative regulation of macroautophagy GO:0016242 9.58 MTOR PIK3CA
13 platelet-derived growth factor receptor signaling pathway GO:0048008 9.58 PDGFA PDGFB PDGFRA
14 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.56 BRCA2 TP53
15 phosphatidylinositol phosphorylation GO:0046854 9.56 PDGFA PDGFB PDGFRA PIK3CA
16 cell activation GO:0001775 9.55 PDGFA PDGFRA
17 positive regulation of protein kinase B signaling GO:0051897 9.55 MTOR PDGFA PDGFB PDGFRA PIK3CA
18 anoikis GO:0043276 9.52 MTOR PIK3CA
19 cell aging GO:0007569 9.5 BRCA2 MTOR TP53
20 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.43 PDGFA PDGFB
21 negative regulation of phosphatidylinositol biosynthetic process GO:0010512 9.37 PDGFA PDGFB
22 positive regulation of fibroblast proliferation GO:0048146 9.26 CCNA2 PDGFA PDGFB PDGFRA
23 negative regulation of platelet activation GO:0010544 8.8 PDGFA PDGFB PDGFRA

Molecular functions related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.73 BRCA2 MTOR PDGFB SKP2 SLC2A1 TP53
2 kinase activity GO:0016301 9.72 CKS1B MTOR PDGFRA PIK3CA SKP2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.58 PDGFA PDGFB PDGFRA
4 platelet-derived growth factor receptor binding GO:0005161 9.33 PDGFA PDGFB PDGFRA
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 PDGFA PDGFB PDGFRA PIK3CA
6 platelet-derived growth factor binding GO:0048407 8.8 PDGFA PDGFB PDGFRA
7 protein binding GO:0005515 10.18 ARID1A BRCA2 CCNA2 CKS1B KRT7 MTOR

Sources for Clear Cell Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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