MCID: CLR012
MIFTS: 38

Clear Cell Adenofibroma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma 12 15
Cystadenofibroma 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5477
MeSH 44 D062625
NCIt 50 C8985 C8987
SNOMED-CT 68 2962009 58161009
UMLS 73 C0334317

Summaries for Clear Cell Adenofibroma

Disease Ontology : 12 An adenofibroma that is characterized by the presence of cells with clear cytoplasm.

MalaCards based summary : Clear Cell Adenofibroma, also known as cystadenofibroma, is related to cystadenofibroma and ovarian clear cell carcinoma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and PI3K/AKT activation. Affiliated tissues include ovary, lung and brain, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 cystadenofibroma 33.4 BRCA2 CALB2 KRT7
2 ovarian clear cell carcinoma 30.3 ARID1A KRT7 PIK3CA
3 ovarian clear cell adenofibroma 12.5
4 mucinous cystadenofibroma 12.4
5 clear cell cystadenofibroma 12.3
6 rete ovarii cystadenofibroma 12.3
7 ovarian serous cystadenofibroma 12.2
8 ovarian mucinous cystadenofibroma 12.2
9 ovarian endometrioid cystadenofibroma 12.0
10 fallopian tube cystadenofibroma 12.0
11 ovarian clear cell cystadenofibroma 11.2
12 adenofibroma 10.6
13 endometriosis 10.3
14 adenocarcinoma 10.3
15 clear cell adenocarcinoma 10.3
16 uterine body mixed cancer 10.2 ARID1A PIK3CA
17 lung adenoid cystic carcinoma 10.2 PDGFRA PIK3CA
18 malignant spiradenoma 10.2 KRT7 PIK3CA
19 dermatosis papulosa nigra 10.2 MTOR PIK3CA
20 ceruminoma 10.2 KRT7 SLC2A1
21 sensory organ benign neoplasm 10.2 CA2 KRT7
22 renal pelvis adenocarcinoma 10.2 KRT7 SLC2A1
23 hidradenoma 10.2 KRT7 PIK3CA
24 large intestine adenocarcinoma 10.2 KRT7 MTOR
25 large cell acanthoma 10.1 KRT7 MTOR
26 renal pelvis carcinoma 10.1 KRT7 SLC2A1
27 breast adenomyoepithelioma 10.1 KRT7 PIK3CA
28 glycogen-rich clear cell breast carcinoma 10.1 BRCA2 KRT7
29 ovary adenocarcinoma 10.1 ARID1A KRT7 PIK3CA
30 breast myoepithelial neoplasm 10.1 KRT7 PIK3CA
31 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.1 ARID1A PIK3CA
32 ovarian clear cell adenocarcinoma 10.1 ARID1A MTOR PIK3CA
33 gastrointestinal system cancer 10.1 KRT7 PDGFRA PIK3CA
34 peritoneum cancer 10.1 BRCA2 KRT7
35 bile duct cystadenocarcinoma 10.1 CALB2 KRT7
36 malignant leydig cell tumor 10.1 CALB2 KRT7
37 fallopian tube adenocarcinoma 10.1 BRCA2 CALB2
38 kidney benign neoplasm 10.1 KRT7 MTOR
39 malignant biphasic mesothelioma 10.1 CALB2 KRT7
40 inverted follicular keratosis 10.1 CALB2 MTOR
41 hemimegalencephaly 10.1 MTOR PIK3CA
42 adenomatoid tumor 10.1 CALB2 KRT7
43 leiomyoma 10.1
44 cystadenoma 10.1
45 neurogenic bowel 10.1 CA2 CALB2
46 ampulla of vater adenocarcinoma 10.1 BRCA2 KRT7
47 mucinous ovarian cystadenoma 10.1 CALB2 KRT7
48 pancreatic neuroendocrine tumor 10.1 BRCA2 MTOR PIK3CA
49 renal cell carcinoma, papillary, 1 10.1 KRT7 MTOR PIK3CA
50 mucinous bronchioloalveolar adenocarcinoma 10.1 CALB2 KRT7

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:



Diseases related to Clear Cell Adenofibroma

Symptoms & Phenotypes for Clear Cell Adenofibroma

GenomeRNAi Phenotypes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.16 MTOR PIK3CA
2 Decreased viability GR00173-A 10.16 CKS1B PDGFRA SKP2
3 Decreased viability GR00221-A-1 10.16 MTOR PDGFRA PIK3CA
4 Decreased viability GR00221-A-2 10.16 CKS1B PIK3CA
5 Decreased viability GR00221-A-3 10.16 PDGFRA
6 Decreased viability GR00221-A-4 10.16 CKS1B MTOR PDGFRA PIK3CA
7 Decreased viability GR00301-A 10.16 SKP2
8 Decreased viability GR00342-S-1 10.16 MTOR
9 Decreased viability GR00342-S-2 10.16 MTOR
10 Decreased viability GR00402-S-2 10.16 CKS1B MTOR PDGFRA PIK3CA SKP2
11 Decreased viability in esophageal squamous lineage GR00235-A 9.23 ARID1A BRCA2 CA2 CALB2 KRT7 PDGFB

MGI Mouse Phenotypes related to Clear Cell Adenofibroma:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.22 ARID1A BRCA2 CA2 CKS1B MTOR PDGFA
2 homeostasis/metabolism MP:0005376 10.2 ARID1A BRCA2 CA2 KRT7 MTOR PDGFA
3 cellular MP:0005384 10.18 ARID1A BRCA2 CKS1B KRT7 MTOR PDGFRA
4 embryo MP:0005380 10.11 ARID1A BRCA2 MTOR PDGFA PDGFB PDGFRA
5 mortality/aging MP:0010768 10.1 ARID1A BRCA2 CA2 CKS1B MTOR PDGFA
6 immune system MP:0005387 10.09 ARID1A BRCA2 CA2 CKS1B MTOR PDGFB
7 endocrine/exocrine gland MP:0005379 10.04 ARID1A BRCA2 CA2 MTOR PDGFRA PIK3CA
8 nervous system MP:0003631 10.02 ARID1A BRCA2 CA2 CALB2 MTOR PDGFA
9 muscle MP:0005369 9.85 ARID1A MTOR PDGFA PDGFB PDGFRA PIK3CA
10 no phenotypic analysis MP:0003012 9.73 ARID1A MTOR PDGFB PDGFRA PIK3CA SLC2A1
11 renal/urinary system MP:0005367 9.7 CA2 KRT7 MTOR PDGFA PDGFB PDGFRA
12 reproductive system MP:0005389 9.61 ARID1A BRCA2 CA2 CKS1B PDGFA PDGFB
13 skeleton MP:0005390 9.17 ARID1A BRCA2 CA2 MTOR PDGFA PDGFRA

Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

Genetic Tests for Clear Cell Adenofibroma

Anatomical Context for Clear Cell Adenofibroma

MalaCards organs/tissues related to Clear Cell Adenofibroma:

41
Ovary, Lung, Brain, Kidney, Breast

Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(show all 18)
# Title Authors Year
1
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. ( 29551085 )
2018
2
Borderline Clear Cell Adenofibroma of the Ovary. ( 28465851 )
2017
3
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. ( 24172789 )
2013
4
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. ( 23153077 )
2013
5
Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma. ( 23419475 )
2013
6
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. ( 28861185 )
2012
7
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ( 22611972 )
2012
8
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. ( 21479128 )
2011
9
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. ( 20890073 )
2010
10
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. ( 19655165 )
2009
11
Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. ( 18600856 )
2008
12
Benign clear cell adenofibroma of the ovary. A case report with literature review. ( 17202822 )
2007
13
Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. ( 10645058 )
2000
14
Ovarian clear cell adenofibroma of borderline malignancy. A case report. ( 2793520 )
1989
15
Proliferating endometrioid cystadenofibroma of the ovary. Report of a case in a teenager. ( 7166119 )
1982
16
Papillary cystadenofibroma of endometrium: a histochemical and ultrastructural study. ( 1203842 )
1975
17
Adenoacanthoma arising in ovarian cystadenofibroma. ( 5517046 )
1970
18
Malignant cystadenofibroma of the ovary: report of a case. ( 5771729 )
1969

Variations for Clear Cell Adenofibroma

Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 MTOR PDGFA PDGFB PDGFRA PIK3CA SKP2
2
Show member pathways
12.98 MTOR PDGFA PDGFB PDGFRA PIK3CA
3
Show member pathways
12.85 MTOR PDGFA PDGFB PDGFRA PIK3CA
4
Show member pathways
12.66 BRCA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
5
Show member pathways
12.64 ARID1A BRCA2 MTOR PIK3CA
6
Show member pathways
12.6 PDGFA PDGFB PDGFRA PIK3CA
7
Show member pathways
12.6 MTOR PDGFA PDGFB PDGFRA PIK3CA
8 12.5 PDGFA PDGFB PDGFRA PIK3CA
9
Show member pathways
12.47 BRCA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
10
Show member pathways
12.46 PDGFA PDGFB PDGFRA PIK3CA
11 12.38 MTOR PDGFA PDGFB PDGFRA PIK3CA
12
Show member pathways
12.35 MTOR PDGFRA PIK3CA SKP2
13
Show member pathways
12.32 MTOR PDGFB PIK3CA SLC2A1
14
Show member pathways
12.26 MTOR PDGFA PDGFB PDGFRA PIK3CA
15
Show member pathways
12.26 MTOR PDGFA PDGFB PDGFRA PIK3CA
16 12.21 PDGFA PDGFB PDGFRA PIK3CA SLC2A1
17
Show member pathways
12.16 MTOR PDGFA PDGFB PDGFRA PIK3CA
18
Show member pathways
12.08 ARID1A MTOR SLC2A1
19
Show member pathways
12.02 PDGFA PDGFB PDGFRA PIK3CA
20 12 BRCA2 CKS1B MTOR PDGFA PDGFB PDGFRA
21 11.97 PDGFA PDGFB PIK3CA
22
Show member pathways
11.96 MTOR PDGFA PDGFB PIK3CA
23 11.87 MTOR PIK3CA SLC2A1
24
Show member pathways
11.83 MTOR PIK3CA SLC2A1
25 11.82 PDGFA PDGFB PDGFRA
26 11.82 MTOR PDGFA PDGFB PDGFRA
27 11.78 MTOR PIK3CA SLC2A1
28 11.74 CKS1B PIK3CA SKP2
29 11.7 PDGFA PDGFB PDGFRA
30 11.46 PDGFA PDGFB PDGFRA SLC2A1
31 11.35 PDGFA PDGFB PDGFRA
32 11.27 BRCA2 CKS1B SKP2
33 11.27 MTOR PDGFRA PIK3CA SLC2A1
34 11.01 PDGFB PDGFRA PIK3CA
35 11 PDGFRA PIK3CA
36 10.77 PDGFB PDGFRA
37 10.62 PDGFA PDGFB PDGFRA PIK3CA

GO Terms for Clear Cell Adenofibroma

Cellular components related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus GO:0005902 8.8 CA2 PDGFA PDGFRA

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.92 CKS1B MTOR PDGFRA PIK3CA SKP2
2 positive regulation of MAPK cascade GO:0043410 9.72 PDGFA PDGFB PDGFRA
3 wound healing GO:0042060 9.67 MTOR PDGFA PDGFRA
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 PDGFA PDGFB PDGFRA
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 MTOR PDGFB SKP2
6 cell aging GO:0007569 9.58 BRCA2 MTOR
7 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737 9.58 CKS1B PDGFB
8 positive regulation of fibroblast proliferation GO:0048146 9.58 PDGFA PDGFB PDGFRA
9 female gonad development GO:0008585 9.57 BRCA2 PDGFRA
10 positive regulation of protein autophosphorylation GO:0031954 9.56 PDGFA PDGFB
11 negative regulation of macroautophagy GO:0016242 9.54 MTOR PIK3CA
12 cell activation GO:0001775 9.51 PDGFA PDGFRA
13 platelet-derived growth factor receptor signaling pathway GO:0048008 9.5 PDGFA PDGFB PDGFRA
14 anoikis GO:0043276 9.48 MTOR PIK3CA
15 phosphatidylinositol phosphorylation GO:0046854 9.46 PDGFA PDGFB PDGFRA PIK3CA
16 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.37 PDGFA PDGFB
17 positive regulation of protein kinase B signaling GO:0051897 9.35 MTOR PDGFA PDGFB PDGFRA PIK3CA
18 negative regulation of phosphatidylinositol biosynthetic process GO:0010512 9.26 PDGFA PDGFB
19 negative regulation of platelet activation GO:0010544 8.8 PDGFA PDGFB PDGFRA

Molecular functions related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.65 CKS1B MTOR PDGFRA PIK3CA SKP2
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 PDGFA PDGFB PDGFRA
3 platelet-derived growth factor receptor binding GO:0005161 9.33 PDGFA PDGFB PDGFRA
4 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 PDGFA PDGFB PDGFRA PIK3CA
5 platelet-derived growth factor binding GO:0048407 8.8 PDGFA PDGFB PDGFRA

Sources for Clear Cell Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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