MCID: CLR012
MIFTS: 25

Clear Cell Adenofibroma

Categories: Cancer diseases
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Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma 11 14
Cystadenofibroma 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:5477
MeSH 43 D062625
NCIt 49 C8985
SNOMED-CT 68 2962009
UMLS 71 C0334317

Summaries for Clear Cell Adenofibroma

Disease Ontology: 11 An adenofibroma that is characterized by the presence of cells with clear cytoplasm.

MalaCards based summary: Clear Cell Adenofibroma, also known as cystadenofibroma, is related to ovarian clear cell adenofibroma and adenofibroma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Pathways affected in adenoid cystic carcinoma. Affiliated tissues include ovary.

Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell adenofibroma 32.5 PIK3CA NAPSA
2 adenofibroma 31.2 NAPSA ARID1A
3 clear cell adenocarcinoma 30.7 NAPSA ARID1A
4 ovarian clear cell adenocarcinoma 30.6 PIK3CA ARID1A
5 endometriosis of ovary 30.3 PIK3CA ARID1A
6 ovary adenocarcinoma 30.0 PIK3CA ARID1A
7 serous cystadenocarcinoma 29.7 PIK3CA NAPSA ARID1A
8 papillary adenofibroma 29.6 SMARCA4 NAPSA ARID1A
9 ovarian clear cell carcinoma 29.3 SMARCA4 PIK3CA PBRM1 NAPSA ARID1A
10 mucinous cystadenofibroma 11.4
11 ovarian serous cystadenofibroma 11.2
12 ovarian clear cell cystadenofibroma 11.2
13 ovarian mucinous cystadenofibroma 11.2
14 fallopian tube cystadenofibroma 11.2
15 ovarian endometrioid cystadenofibroma 11.1
16 rete ovarii cystadenofibroma 11.1
17 endometriosis 10.4
18 clear cell adenocarcinoma of the ovary 10.3
19 adenocarcinoma 10.2
20 bartholin's gland adenoid cystic carcinoma 10.2 PIK3CA ARID1A
21 ovarian cancer 10.2
22 cystadenoma 10.2
23 ovarian carcinosarcoma 10.2 PIK3CA ARID1A
24 breast juvenile papillomatosis 10.2 PIK3CA ARID1A
25 female reproductive endometrioid cancer 10.2 PIK3CA ARID1A
26 endometrial serous adenocarcinoma 10.1 PIK3CA ARID1A
27 mismatch repair cancer syndrome 10.1 PIK3CA ARID1A
28 leiomyoma 10.1
29 small-cell carcinoma of the ovary of hypercalcemic type 10.1 SMARCA4 ARID1A
30 keratinizing squamous cell carcinoma 10.1 PIK3CA NAPSA
31 mixed cell type cancer 10.1 PIK3CA ARID1A
32 uterine body mixed cancer 10.1 PIK3CA ARID1A
33 endocervical carcinoma 10.1 PIK3CA ARID1A
34 uterine benign neoplasm 10.1 PIK3CA ARID1A
35 small cell carcinoma 10.1 SMARCA4 NAPSA
36 mucinous adenocarcinoma 10.1 PIK3CA NAPSA
37 reproductive organ benign neoplasm 10.1 PIK3CA ARID1A
38 clark-baraitser syndrome 10.1 SMARCA4 ARID1A
39 spinal canal and spinal cord meningioma 10.1 PBRM1 ARID1A
40 spinal meningioma 10.1 PBRM1 ARID1A
41 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 10.1 PIK3CA ARID1A
42 autosomal dominant intellectual developmental disorder 10.1 SMARCA4 ARID1A
43 endocervical adenocarcinoma 10.1 PIK3CA ARID1A
44 ovarian serous cystadenocarcinoma 10.1
45 premature menopause 10.1
46 constipation 10.1
47 epithelial-myoepithelial carcinoma 10.1
48 cystadenofibroma 10.1
49 clear cell cystadenofibroma 10.1
50 posttransplant acute limbic encephalitis 10.1

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:



Diseases related to Clear Cell Adenofibroma

Symptoms & Phenotypes for Clear Cell Adenofibroma

Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials, NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

Genetic Tests for Clear Cell Adenofibroma

Anatomical Context for Clear Cell Adenofibroma

Organs/tissues related to Clear Cell Adenofibroma:

MalaCards : Ovary

Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(show all 30)
# Title Authors PMID Year
1
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 62
29551085 2018
2
Possible de novo clear cell carcinoma in the contralateral ovary 9 years after fertility-sparing surgery for Stage IA clear cell ovarian carcinoma. 62
31149470 2017
3
Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary. 62
27987343 2017
4
Borderline Clear Cell Adenofibroma of the Ovary. 62
28465851 2017
5
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes. 62
27167231 2016
6
Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours. 62
27334714 2016
7
Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. 62
27699033 2016
8
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome. 62
27340747 2016
9
Napsin A is a specific marker for ovarian clear cell adenocarcinoma. 62
24721826 2015
10
Clear cell adenocarcinoma arising from clear cell adenofibroma of the ovary: value of DWI and DCE-MRI. 62
24172789 2013
11
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. 62
23153077 2013
12
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? 62
22655678 2012
13
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. 62
22498943 2012
14
Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations. 62
22157930 2012
15
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. 62
22611972 2012
16
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. 62
22120431 2012
17
Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas. 62
21983935 2012
18
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. 62
28861185 2012
19
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. 62
21479128 2011
20
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. 62
20890073 2010
21
Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways. 62
19855998 2009
22
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. 62
19655165 2009
23
Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. 62
18600856 2008
24
Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. 62
18084257 2008
25
Benign clear cell adenofibroma of the ovary. A case report with literature review. 62
17202822 2007
26
Unexpected gynecologic neoplasms in patients with proven or suspected BRCA-1 or -2 mutations: implications for gross examination, cytology, and clinical follow-up. 62
11812938 2002
27
Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. 62
10645058 2000
28
A pregnant woman with clear cell adenocarcinoma of the ovary arising from endometriosis and with benign and borderline adenofibroma of the clear cell and endometrioid types. 62
9076421 1997
29
Ovarian clear cell adenofibroma of borderline malignancy. A case report. 62
2793520 1989
30
Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma. 62
6692303 1984

Variations for Clear Cell Adenofibroma

Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.1 SMARCA4 ARID1A
2 10.95 PIK3CA ARID1A
3
Show member pathways
10.49 SMARCA4 ARID1A
4 10.38 SMARCA4 PBRM1 ARID1A

GO Terms for Clear Cell Adenofibroma

Cellular components related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nBAF complex GO:0071565 9.73 SMARCA4 ARID1A
2 RSC-type complex GO:0016586 9.71 SMARCA4 PBRM1
3 GBAF complex GO:0140288 9.67 SMARCA4 BICRAL
4 npBAF complex GO:0071564 9.62 SMARCA4 ARID1A
5 bBAF complex GO:0140092 9.56 SMARCA4 ARID1A
6 SWI/SNF complex GO:0016514 9.23 SMARCA4 PBRM1 BICRAL ARID1A
7 DNA packaging complex GO:0044815 9.16 SMARCA4 ARID1A
8 SWI/SNF superfamily-type complex GO:0070603 8.96 SMARCA4 ARID1A

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 10.03 SMARCA4 PBRM1 BICRAL ARID1A
2 positive regulation of cell differentiation GO:0045597 9.95 SMARCA4 PBRM1 ARID1A
3 regulation of G1/S transition of mitotic cell cycle GO:2000045 9.93 SMARCA4 PBRM1 ARID1A
4 positive regulation of stem cell population maintenance GO:1902459 9.88 SMARCA4 BICRAL ARID1A
5 positive regulation of myoblast differentiation GO:0045663 9.85 ARID1A PBRM1 SMARCA4
6 nucleosome disassembly GO:0006337 9.8 SMARCA4 ARID1A
7 positive regulation of double-strand break repair GO:2000781 9.8 SMARCA4 PBRM1 ARID1A
8 positive regulation of T cell differentiation GO:0045582 9.73 SMARCA4 PBRM1 ARID1A
9 regulation of mitotic metaphase/anaphase transition GO:0030071 9.63 SMARCA4 PBRM1 ARID1A
10 regulation of nucleotide-excision repair GO:2000819 9.43 SMARCA4 PBRM1 ARID1A
11 regulation of G0 to G1 transition GO:0070316 9.1 SMARCA4 PBRM1 ARID1A

Sources for Clear Cell Adenofibroma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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