MCID: CLR012
MIFTS: 34

Clear Cell Adenofibroma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma 12 15
Cystadenofibroma 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5477
MeSH 44 D062625
NCIt 50 C8985 C8987
SNOMED-CT 68 2962009 58161009
UMLS 73 C0334317

Summaries for Clear Cell Adenofibroma

MalaCards based summary : Clear Cell Adenofibroma, also known as cystadenofibroma, is related to cystadenofibroma and ovarian clear cell carcinoma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are PI3K-Akt signaling pathway and TCR Signaling (Qiagen). Affiliated tissues include ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 cystadenofibroma 32.5 BRCA1 BRCA2 CALB2 KRT7
2 ovarian clear cell carcinoma 30.6 ARID1A KRT7 PIK3CA
3 ovarian clear cell adenofibroma 12.4
4 ovarian serous cystadenofibroma 12.1
5 mucinous cystadenofibroma 12.1
6 ovarian mucinous cystadenofibroma 12.0
7 clear cell cystadenofibroma 11.9
8 ovarian clear cell cystadenofibroma 11.9
9 rete ovarii cystadenofibroma 11.9
10 ovarian endometrioid cystadenofibroma 11.9
11 fallopian tube cystadenofibroma 11.9
12 malignant spiradenoma 10.7 KRT7 PIK3CA
13 dermatosis papulosa nigra 10.7 MTOR PIK3CA
14 pancreatic neuroendocrine tumor 10.7 MTOR PIK3CA
15 renal pelvis adenocarcinoma 10.6 KRT7 SLC2A1
16 large intestine adenocarcinoma 10.6 KRT7 MTOR
17 hereditary site-specific ovarian cancer syndrome 10.6 BRCA1 BRCA2
18 large cell acanthoma 10.5 KRT7 MTOR
19 breast reconstruction 10.5 BRCA1 BRCA2
20 tuberculous salpingitis 10.5 BRCA1 BRCA2
21 nosophobia 10.5 BRCA1 BRCA2
22 cancerophobia 10.5 BRCA1 BRCA2
23 hemimegalencephaly 10.5 MTOR PIK3CA
24 undifferentiated pleomorphic sarcoma 10.5 PDGFRA PIK3CA
25 hidradenoma 10.5 KRT7 PIK3CA
26 uterine corpus serous adenocarcinoma 10.5 BRCA1 BRCA2
27 adenofibroma 10.5
28 ovarian clear cell adenocarcinoma 10.5 ARID1A MTOR PIK3CA
29 breast-ovarian cancer, familial 1 10.5 BRCA1 BRCA2
30 papillary serous adenocarcinoma 10.4 BRCA1 KRT7
31 synchronous bilateral breast carcinoma 10.4 BRCA1 BRCA2
32 gastrointestinal system cancer 10.4 KRT7 PDGFRA PIK3CA
33 renal pelvis carcinoma 10.4 KRT7 SLC2A1
34 peritoneum cancer 10.4 BRCA1 BRCA2
35 mucinous bronchioloalveolar adenocarcinoma 10.4 CALB2 KRT7
36 bile duct cystadenocarcinoma 10.3 CALB2 KRT7
37 malignant leydig cell tumor 10.3 CALB2 KRT7
38 premature menopause 10.3 BRCA1 BRCA2
39 inverted follicular keratosis 10.3 CALB2 MTOR
40 mucinous ovarian cystadenoma 10.3 CALB2 KRT7
41 adenomatoid tumor 10.3 CALB2 KRT7
42 cowden disease 10.3 BRCA1 BRCA2 PIK3CA
43 glycogen-rich clear cell breast carcinoma 10.2 BRCA1 BRCA2 KRT7
44 endometriosis 10.1
45 adenocarcinoma 10.1
46 clear cell adenocarcinoma 10.1
47 clear cell renal cell carcinoma 10.1 KRT7 MTOR SLC2A1
48 neurogenic bowel 10.1 CA2 CALB2
49 kidney benign neoplasm 10.1 KRT7 MTOR
50 glioblastoma multiforme 10.1 MTOR PDGFB PDGFRA PIK3CA

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:



Diseases related to Clear Cell Adenofibroma

Symptoms & Phenotypes for Clear Cell Adenofibroma

GenomeRNAi Phenotypes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.93 PDGFRA SKP2 CKS1B
2 Decreased viability GR00221-A-1 9.93 PDGFRA
3 Decreased viability GR00221-A-2 9.93 CKS1B
4 Decreased viability GR00221-A-3 9.93 PDGFRA
5 Decreased viability GR00221-A-4 9.93 CKS1B PDGFRA
6 Decreased viability GR00301-A 9.93 SKP2
7 Decreased viability GR00402-S-2 9.93 PDGFRA SKP2 CKS1B
8 Decreased viability in esophageal squamous lineage GR00235-A 9.61 KRT7 PDGFB PDGFRA PIK3CA ARID1A BRCA1
9 Decreased viability with cisplatin GR00101-A-4 8.8 BRCA1 BRCA2 CKS1B

MGI Mouse Phenotypes related to Clear Cell Adenofibroma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 MTOR PDGFRA PDGFA PIK3CA PDGFB SKP2
2 homeostasis/metabolism MP:0005376 10.27 PIK3CA KRT7 PDGFB MTOR PDGFRA PDGFA
3 cellular MP:0005384 10.25 KRT7 MTOR PDGFRA PIK3CA SKP2 SLC2A1
4 mortality/aging MP:0010768 10.2 PDGFB MTOR PDGFRA PDGFA PIK3CA SLC2A1
5 embryo MP:0005380 10.19 PDGFB MTOR PDGFRA PDGFA PIK3CA SLC2A1
6 immune system MP:0005387 10.18 PDGFB MTOR PDGFRA PIK3CA SKP2 CA2
7 endocrine/exocrine gland MP:0005379 10.13 MTOR PDGFRA PIK3CA SKP2 CA2 BRCA1
8 nervous system MP:0003631 10.11 PDGFB MTOR PDGFRA PDGFA PIK3CA SLC2A1
9 muscle MP:0005369 9.98 PDGFB MTOR PDGFRA PDGFA PIK3CA BRCA1
10 neoplasm MP:0002006 9.88 PDGFRA PIK3CA ARID1A BRCA1 CKS1B BRCA2
11 renal/urinary system MP:0005367 9.86 PDGFB MTOR PDGFRA PDGFA SKP2 CA2
12 reproductive system MP:0005389 9.85 PDGFRA PDGFA PIK3CA PDGFB SKP2 BRCA1
13 no phenotypic analysis MP:0003012 9.8 PDGFB MTOR PDGFRA PIK3CA SLC2A1 ARID1A
14 respiratory system MP:0005388 9.43 PDGFB MTOR PDGFRA PDGFA CA2 BRCA1
15 skeleton MP:0005390 9.23 MTOR PDGFRA PDGFA PIK3CA CA2 BRCA1

Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

Genetic Tests for Clear Cell Adenofibroma

Anatomical Context for Clear Cell Adenofibroma

MalaCards organs/tissues related to Clear Cell Adenofibroma:

41
Ovary

Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(show all 13)
# Title Authors Year
1
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. ( 29551085 )
2018
2
Borderline Clear Cell Adenofibroma of the Ovary. ( 28465851 )
2017
3
Clear Cell Adenocarcinoma Arising from Clear Cell Adenofibroma of the Ovary: Value of DWI and DCE-MRI. ( 24172789 )
2013
4
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. ( 23153077 )
2013
5
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. ( 28861185 )
2012
6
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ( 22611972 )
2012
7
Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. ( 21479128 )
2011
8
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. ( 20890073 )
2010
9
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. ( 19655165 )
2009
10
Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. ( 18600856 )
2008
11
Benign clear cell adenofibroma of the ovary. A case report with literature review. ( 17202822 )
2007
12
Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. ( 10645058 )
2000
13
Ovarian clear cell adenofibroma of borderline malignancy. A case report. ( 2793520 )
1989

Variations for Clear Cell Adenofibroma

Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.84 BRCA1 MTOR PDGFA PDGFB PDGFRA PIK3CA
2
Show member pathways
12.8 BRCA1 BRCA2 PDGFA PDGFB PDGFRA
3
Show member pathways
12.7 BRCA2 MTOR PDGFA PDGFB PDGFRA PIK3CA
4
Show member pathways
12.65 ARID1A BRCA1 BRCA2 MTOR PIK3CA
5
Show member pathways
12.61 MTOR PDGFA PDGFB PDGFRA PIK3CA
6 12.51 PDGFA PDGFB PDGFRA PIK3CA
7
Show member pathways
12.5 MTOR PDGFA PDGFB PDGFRA PIK3CA
8
Show member pathways
12.48 PDGFA PDGFB PDGFRA PIK3CA
9
Show member pathways
12.37 MTOR PDGFRA PIK3CA SKP2
10
Show member pathways
12.37 BRCA1 BRCA2 MTOR PDGFA PDGFB PDGFRA
11
Show member pathways
12.35 MTOR PDGFB PIK3CA SLC2A1
12 12.24 PDGFA PDGFB PDGFRA PIK3CA SLC2A1
13 12.21 BRCA1 MTOR PDGFA PDGFB PDGFRA PIK3CA
14
Show member pathways
12.19 MTOR PDGFA PDGFB PDGFRA PIK3CA
15 12.03 BRCA1 BRCA2 MTOR
16
Show member pathways
12.03 PDGFA PDGFB PDGFRA PIK3CA
17 12 BRCA2 CKS1B MTOR PDGFA PDGFB PDGFRA
18
Show member pathways
11.98 BRCA1 MTOR PDGFA PDGFB PIK3CA
19 11.97 PDGFA PDGFB PIK3CA
20 11.89 MTOR PIK3CA SLC2A1
21
Show member pathways
11.85 MTOR PIK3CA SLC2A1
22 11.84 MTOR PDGFA PDGFB PDGFRA
23 11.82 PDGFA PDGFB PDGFRA
24 11.8 MTOR PIK3CA SLC2A1
25 11.76 CKS1B PIK3CA SKP2
26 11.72 PDGFA PDGFB PDGFRA
27 11.59 ARID1A BRCA1 PIK3CA
28 11.57 PDGFA PDGFB PDGFRA SLC2A1
29 11.44 MTOR PDGFRA PIK3CA SLC2A1
30 11.36 PDGFA PDGFB PDGFRA
31 11.27 BRCA2 CKS1B SKP2
32 11.01 PDGFB PDGFRA PIK3CA
33 11 PDGFRA PIK3CA
34 10.78 PDGFB PDGFRA
35 10.62 PDGFA PDGFB PDGFRA PIK3CA

GO Terms for Clear Cell Adenofibroma

Cellular components related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 9.16 BRCA1 BRCA2
2 phosphatidylinositol 3-kinase complex GO:0005942 8.96 MTOR PIK3CA
3 microvillus GO:0005902 8.8 CA2 PDGFA PDGFRA

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.97 CKS1B MTOR PDGFRA PIK3CA SKP2
2 positive regulation of transcription, DNA-templated GO:0045893 9.96 ARID1A BRCA1 BRCA2 CKS1B PDGFB
3 positive regulation of MAPK cascade GO:0043410 9.78 PDGFA PDGFB PDGFRA
4 wound healing GO:0042060 9.72 MTOR PDGFA PDGFRA
5 cell chemotaxis GO:0060326 9.7 PDGFB PDGFRA PIK3CA
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 PDGFA PDGFB PDGFRA
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.67 MTOR PDGFB SKP2
8 positive regulation of fibroblast proliferation GO:0048146 9.65 PDGFA PDGFB PDGFRA
9 positive regulation of DNA replication GO:0045740 9.61 PDGFA PDGFB PDGFRA
10 positive regulation of protein autophosphorylation GO:0031954 9.6 PDGFA PDGFB
11 cell activation GO:0001775 9.59 PDGFA PDGFRA
12 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.58 BRCA1 BRCA2
13 negative regulation of macroautophagy GO:0016242 9.57 MTOR PIK3CA
14 phosphatidylinositol phosphorylation GO:0046854 9.56 PDGFA PDGFB PDGFRA PIK3CA
15 positive regulation of protein kinase B signaling GO:0051897 9.55 MTOR PDGFA PDGFB PDGFRA PIK3CA
16 anoikis GO:0043276 9.54 MTOR PIK3CA
17 platelet-derived growth factor receptor signaling pathway GO:0048008 9.54 PDGFA PDGFB PDGFRA
18 chordate embryonic development GO:0043009 9.46 BRCA1 BRCA2
19 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway GO:0035793 9.4 PDGFA PDGFB
20 negative regulation of phosphatidylinositol biosynthetic process GO:0010512 9.32 PDGFA PDGFB
21 negative regulation of platelet activation GO:0010544 9.13 PDGFA PDGFB PDGFRA
22 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 8.8 PDGFA PDGFB PDGFRA

Molecular functions related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.72 CKS1B MTOR PDGFRA PIK3CA SKP2
2 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 PDGFA PDGFB PDGFRA
3 platelet-derived growth factor receptor binding GO:0005161 9.33 PDGFA PDGFB PDGFRA
4 growth factor receptor binding GO:0070851 9.26 PDGFA PDGFB
5 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 PDGFA PDGFB PDGFRA PIK3CA
6 platelet-derived growth factor binding GO:0048407 8.8 PDGFA PDGFB PDGFRA

Sources for Clear Cell Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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