MCID: CLR012
MIFTS: 27

Clear Cell Adenofibroma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma 12 15
Cystadenofibroma 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5477
MeSH 43 D062625
NCIt 49 C8985 C8987
SNOMED-CT 67 2962009 58161009
UMLS 71 C0334317

Summaries for Clear Cell Adenofibroma

Disease Ontology : 12 An adenofibroma that is characterized by the presence of cells with clear cytoplasm.

MalaCards based summary : Clear Cell Adenofibroma, also known as cystadenofibroma, is related to ovarian clear cell adenofibroma and clear cell adenocarcinoma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are Pathways in cancer and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include ovary, thyroid and breast, and related phenotype is neoplasm.

Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 ovarian clear cell adenofibroma 34.0 PIK3CA NAPSA
2 clear cell adenocarcinoma 30.3 PIK3CA NAPSA ARID1A
3 ovarian clear cell adenocarcinoma 30.1 PIK3CA NAPSA ARID1A
4 ovarian serous cystadenocarcinoma 29.4 PPP2R1A PIK3CA ARID1A
5 ovarian clear cell carcinoma 28.9 PPP2R1A PIK3CA NAPSA ARID1A
6 mucinous cystadenofibroma 12.6
7 ovarian serous cystadenofibroma 12.4
8 ovarian mucinous cystadenofibroma 12.3
9 ovarian endometrioid cystadenofibroma 12.3
10 rete ovarii cystadenofibroma 12.2
11 fallopian tube cystadenofibroma 12.2
12 ovarian clear cell cystadenofibroma 11.4
13 adenofibroma 10.7
14 endometriosis 10.4
15 clear cell adenocarcinoma of the ovary 10.3
16 leiomyoma 10.3
17 amenorrhea 10.2
18 cystadenoma 10.2
19 infertility 10.2
20 papillary carcinoma 10.1
21 premature ovarian failure 1 10.1
22 endometriosis of ovary 10.1
23 constipation 10.1
24 adenocarcinoma 10.1
25 cystadenofibroma 10.1
26 clear cell cystadenofibroma 10.1
27 posttransplant acute limbic encephalitis 10.1
28 overgrowth syndrome 10.1
29 renal cell carcinoma, nonpapillary 10.0
30 leiomyoma, uterine 10.0
31 ovarian cancer 10.0
32 thyroid cancer, nonmedullary, 1 10.0
33 androgen insensitivity syndrome 10.0
34 endometrial cancer 10.0
35 hydrops, lactic acidosis, and sideroblastic anemia 10.0
36 angiosarcoma 10.0
37 multinodular goiter 10.0
38 colorectal adenocarcinoma 10.0
39 inguinal hernia 10.0
40 ectopic pregnancy 10.0
41 endometrial hyperplasia 10.0
42 klippel-feil syndrome 10.0
43 sarcoma 10.0
44 endosalpingiosis 10.0
45 goiter 10.0
46 endodermal sinus tumor 10.0
47 adenosarcoma 10.0
48 ovarian brenner tumor 10.0
49 struma ovarii 10.0
50 teratoma 10.0

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:



Diseases related to Clear Cell Adenofibroma

Symptoms & Phenotypes for Clear Cell Adenofibroma

MGI Mouse Phenotypes related to Clear Cell Adenofibroma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 ARID1A CKS1B PIK3CA PPP2R1A

Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

Genetic Tests for Clear Cell Adenofibroma

Anatomical Context for Clear Cell Adenofibroma

MalaCards organs/tissues related to Clear Cell Adenofibroma:

40
Ovary, Thyroid, Breast, Lymph Node, Kidney, Skin, Appendix

Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Imaging in gynecological disease (16): clinical and ultrasound characteristics of serous cystadenofibromas in adnexa. 61
30937992 2019
2
Tumor-to-Tumor Metastasis of Colorectal Adenocarcinoma to Ovarian Cystadenofibroma: A Case Report and Review of the Literature. 61
30882401 2019
3
Incidental Gynecologic Tract Neoplasms in Women Undergoing Anterior Pelvic Exenteration for Urothelial Carcinoma. 61
29257039 2019
4
Laparoscopic excision of a retroperitoneal mucinous cystic neoplasm: A case report. 61
31421556 2019
5
Serous cystadenofibroma misdiagnosed as an ovarian malignancy. 61
30567152 2018
6
Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. 61
29551085 2018
7
Unusual case of anti-N-methyl-D-aspartic acid-receptor (NMDA-R) encephalitis and autoimmune polyglandular syndrome (APS). 61
29724875 2018
8
Microscopic Heterotopic Extraovarian Sex Cord-Stromal Proliferations: Expanding the Histologic Spectrum. 61
28319576 2018
9
Three-dimensional ultrasound and HDlive in tubal serous cystadenofibroma: a case report and literature review. 61
29197922 2017
10
Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnosis. 61
27484484 2017
11
Possible de novo clear cell carcinoma in the contralateral ovary 9 years after fertility-sparing surgery for Stage IA clear cell ovarian carcinoma. 61
31149470 2017
12
Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary. 61
27987343 2017
13
Diagnostic Imaging of Pregnant Women - The Role of Magnetic Resonance Imaging. 61
28507642 2017
14
Borderline Clear Cell Adenofibroma of the Ovary. 61
28465851 2017
15
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes. 61
27167231 2016
16
Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours. 61
27334714 2016
17
Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. 61
27699033 2016
18
Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome. 61
27340747 2016
19
Large ovarian cystadenofibroma causing large bowel obstruction in a patient with Klippel-Feil syndrome-A case report. 61
26780471 2016
20
Serous Tubal Intraepithelial Carcinoma (STIC)-like Lesions Arising in Ovarian Serous Cystadenofibroma: Report of 2 Cases. 61
26107558 2015
21
Serous papillary cystadenofibroma of the fallopian tube: A case report and short review of literature. 61
26549083 2015
22
Cystadenofibromas: Can transvaginal ultrasound appearance reduce some surgical interventions? 61
25271400 2015
23
Napsin A is a specific marker for ovarian clear cell adenocarcinoma. 61
24721826 2015
24
Prevalence of extrauterine pelvic lesions on transvaginal ultrasound in asymptomatic 20-39-year-old women. 61
24375888 2014
25
Endosalpingiosis in conjunction with ovarian serous cystadenoma mimicking metastatic ovarian malignancy. 61
25180540 2014
26
Complete androgen insensitivity syndrome with a large gonadal serous papillary cystadenofibroma. 61
25191030 2014
27
HDlive rendering image of adnexal tumors: preliminary report. 61
27277771 2014
28
A case of mucinous cystadenofibroma of the ovary. 61
24772358 2014
29
An unusual case of a borderline Brenner tumor associated with bilateral serous cystadenoma and endometrial carcinoma. 61
24791367 2014
30
Clear cell adenocarcinoma arising from clear cell adenofibroma of the ovary: value of DWI and DCE-MRI. 61
24172789 2013
31
Large functional benign endometroid cystadenofibroma of the ovary leading to endometrial cystic glandular hyperplasia and postmenopausal bleeding. 61
23761571 2013
32
Single-incision pediatric endosurgery for ovarian pathology. 61
23402287 2013
33
Anti-N-methyl-d-aspartate encephalitis with ovarian cystadenofibroma. 61
23419475 2013
34
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. 61
23153077 2013
35
Giant ovarian cystadenofibroma mimicking ascites in an elderly adult. 61
23405932 2013
36
Serous cystadenofibroma of the ovary. 61
23231836 2012
37
[Mucinous cystadenofiobroma of the ovary]. 61
23297622 2012
38
Fine needle aspiration cytology in ovarian lesions: an institutional experience of 584 cases. 61
21883539 2012
39
Peritoneal washing cytology in patients with BRCA1 or BRCA2 mutations undergoing risk-reducing salpingo-oophorectomies: a 10-year experience and reappraisal of its clinical utility. 61
22425664 2012
40
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? 61
22655678 2012
41
Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. 61
22498943 2012
42
Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations. 61
22157930 2012
43
Primary peritoneal borderline mucinous cystadenofibroma. 61
21971577 2012
44
False-positive I-131 uptake by an ovarian serous cystadenofibroma. 61
22228346 2012
45
Radioiodine accumulation in a giant ovarian cystadenofibroma detected incidentally by 131-I whole body scans. 61
23119215 2012
46
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. 61
22120431 2012
47
Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas. 61
21983935 2012
48
Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. 61
28861185 2012
49
Serous cystadenofibroma of the fallopian tube: case report and literature review. 61
22357436 2012
50
Well-differentiated papillary mesothelioma of the female peritoneum: a clinicopathologic study of 26 cases. 61
22024662 2012

Variations for Clear Cell Adenofibroma

Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.22 PIK3CA PDGFA CKS1B
2
Show member pathways
11.97 PPP2R1A PIK3CA PDGFA
3 11.22 PIK3CA CKS1B
4 10.78 PIK3CA ARID1A
5 9.98 PIK3CA PDGFA

GO Terms for Clear Cell Adenofibroma

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.62 PIK3CA PDGFA

Sources for Clear Cell Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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