Clear Cell Adenofibroma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Clear Cell Adenofibroma

MalaCards integrated aliases for Clear Cell Adenofibroma:

Name: Clear Cell Adenofibroma ¹¹ ¹⁴

Cystadenofibroma ⁴³ ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:5477

MeSH ⁴³ D062625

NCIt ⁴⁹ C8985

SNOMED-CT ⁶⁸ 2962009

UMLS ⁷¹ C0334317

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Summaries for Clear Cell Adenofibroma

Disease Ontology: ¹¹ An adenofibroma that is characterized by the presence of cells with clear cytoplasm.

MalaCards based summary: Clear Cell Adenofibroma, also known as cystadenofibroma, is related to ovarian clear cell adenofibroma and adenofibroma. An important gene associated with Clear Cell Adenofibroma is ARID1A (AT-Rich Interaction Domain 1A), and among its related pathways/superpathways are Transcription Ligand-dependent activation of the ESR1/SP pathway and Pathways affected in adenoid cystic carcinoma. Affiliated tissues include ovary.

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Related Diseases for Clear Cell Adenofibroma

Diseases related to Clear Cell Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 112, show less)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian clear cell adenofibroma	32.5	PIK3CA NAPSA
2	adenofibroma	31.2	NAPSA ARID1A
3	clear cell adenocarcinoma	30.7	NAPSA ARID1A
4	ovarian clear cell adenocarcinoma	30.6	PIK3CA ARID1A
5	endometriosis of ovary	30.3	PIK3CA ARID1A
6	ovary adenocarcinoma	30.0	PIK3CA ARID1A
7	serous cystadenocarcinoma	29.7	PIK3CA NAPSA ARID1A
8	papillary adenofibroma	29.6	SMARCA4 NAPSA ARID1A
9	ovarian clear cell carcinoma	29.3	SMARCA4 PIK3CA PBRM1 NAPSA ARID1A
10	mucinous cystadenofibroma	11.4
11	ovarian serous cystadenofibroma	11.2
12	ovarian clear cell cystadenofibroma	11.2
13	ovarian mucinous cystadenofibroma	11.2
14	fallopian tube cystadenofibroma	11.2
15	ovarian endometrioid cystadenofibroma	11.1
16	rete ovarii cystadenofibroma	11.1
17	endometriosis	10.4
18	clear cell adenocarcinoma of the ovary	10.3
19	adenocarcinoma	10.2
20	bartholin's gland adenoid cystic carcinoma	10.2	PIK3CA ARID1A
21	ovarian carcinosarcoma	10.2	PIK3CA ARID1A
22	breast juvenile papillomatosis	10.2	PIK3CA ARID1A
23	ovarian cancer	10.2
24	cystadenoma	10.2
25	female reproductive endometrioid cancer	10.2	PIK3CA ARID1A
26	endometrial serous adenocarcinoma	10.2	PIK3CA ARID1A
27	mismatch repair cancer syndrome	10.1	PIK3CA ARID1A
28	mixed cell type cancer	10.1	PIK3CA ARID1A
29	small-cell carcinoma of the ovary of hypercalcemic type	10.1	SMARCA4 ARID1A
30	uterine body mixed cancer	10.1	PIK3CA ARID1A
31	keratinizing squamous cell carcinoma	10.1	PIK3CA NAPSA
32	leiomyoma	10.1
33	endocervical carcinoma	10.1	PIK3CA ARID1A
34	uterine benign neoplasm	10.1	PIK3CA ARID1A
35	reproductive organ benign neoplasm	10.1	PIK3CA ARID1A
36	mucinous adenocarcinoma	10.1	PIK3CA NAPSA
37	diffuse gastric and lobular breast cancer syndrome	10.1	PIK3CA ARID1A
38	small cell carcinoma	10.1	SMARCA4 NAPSA
39	clark-baraitser syndrome	10.1	SMARCA4 ARID1A
40	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	10.1	PIK3CA ARID1A
41	spinal canal and spinal cord meningioma	10.1	PBRM1 ARID1A
42	spinal meningioma	10.1	PBRM1 ARID1A
43	endocervical adenocarcinoma	10.1	PIK3CA ARID1A
44	autosomal dominant intellectual developmental disorder	10.1	SMARCA4 ARID1A
45	diffuse gastric cancer	10.1	PIK3CA ARID1A
46	ovarian serous cystadenocarcinoma	10.1
47	premature menopause	10.1
48	epithelial-myoepithelial carcinoma	10.1
49	cystadenofibroma	10.1
50	clear cell cystadenofibroma	10.1
51	posttransplant acute limbic encephalitis	10.1
52	overgrowth syndrome	10.1
53	ovarian cystadenocarcinoma	10.1	PIK3CA ARID1A
54	small intestine cancer	10.0	PIK3CA ARID1A
55	clear cell meningioma	10.0	SMARCA4 PBRM1
56	uterine corpus cancer	10.0	PIK3CA ARID1A
57	thyroid cancer, nonmedullary, 1	10.0
58	amenorrhea	10.0
59	papillary carcinoma	10.0
60	rare tumor	10.0
61	rare benign ovarian tumor	10.0
62	endometrioid ovary carcinoma	10.0	SMARCA4 PIK3CA ARID1A
63	uterine carcinosarcoma	9.9	PIK3CA ARID1A
64	hereditary breast ovarian cancer syndrome	9.9	SMARCA4 PIK3CA ARID1A
65	intrahepatic cholangiocarcinoma	9.9	PBRM1 ARID1A
66	uterine corpus endometrial carcinoma	9.9	PIK3CA PBRM1 ARID1A
67	ovarian small cell carcinoma	9.9	SMARCA4 PBRM1 ARID1A
68	neurilemmomatosis	9.9	SMARCA4 PBRM1 ARID1A
69	rhabdoid cancer	9.9	SMARCA4 PBRM1 ARID1A
70	type 2 diabetes mellitus	9.8
71	leiomyoma, uterine	9.8
72	lymphatic malformation 5	9.8
73	testicular germ cell tumor	9.8
74	hypothyroidism, congenital, nongoitrous, 1	9.8
75	androgen insensitivity syndrome	9.8
76	thyroid carcinoma, hurthle cell	9.8
77	ovarian cancer 1	9.8
78	endometrial cancer	9.8
79	diabetes mellitus, insulin-resistant, with acanthosis nigricans	9.8
80	angiosarcoma	9.8
81	multinodular goiter	9.8
82	colorectal adenocarcinoma	9.8
83	ectopic pregnancy	9.8
84	complete androgen insensitivity syndrome	9.8
85	klippel-feil syndrome	9.8
86	endosalpingiosis	9.8
87	goiter	9.8
88	diarrhea	9.8
89	endodermal sinus tumor	9.8
90	adenosarcoma	9.8
91	struma ovarii	9.8
92	myoma	9.8
93	endometrial adenocarcinoma	9.8
94	teratoma	9.8
95	mutism	9.8
96	endometrial stromal sarcoma	9.8
97	malignant adenofibroma	9.8
98	ovarian cyst	9.8
99	uterine corpus sarcoma	9.8
100	infertility	9.8
101	testicular yolk sac tumor	9.8
102	adenoid squamous cell carcinoma	9.8
103	appendicitis	9.8
104	ileus	9.8
105	encephalitis	9.8
106	ovarian epithelial cancer	9.8
107	ovarian remnant syndrome	9.8
108	urachal cyst	9.8
109	uterine sarcoma	9.8
110	germ cell tumor	9.8
111	syndrome with 46,xy disorder of sex development	9.8
112	thyroid carcinoma	9.8

Graphical network of the top 20 diseases related to Clear Cell Adenofibroma:

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Symptoms & Phenotypes for Clear Cell Adenofibroma

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Drugs & Therapeutics for Clear Cell Adenofibroma

Search Clinical Trials, NIH Clinical Center for Clear Cell Adenofibroma

Cochrane evidence based reviews: cystadenofibroma

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Genetic Tests for Clear Cell Adenofibroma

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Anatomical Context for Clear Cell Adenofibroma

Organs/tissues related to Clear Cell Adenofibroma:

MalaCards : Ovary

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Publications for Clear Cell Adenofibroma

Articles related to Clear Cell Adenofibroma:

(showing 30, show less)

#	Title	Authors	PMID	Year
1	Ovarian Clear Cell Adenofibroma of Low Malignant Potential Developing Into Clear Cell Adenocarcinoma. ⁶²	Yin Z...Heller D	29551085	2018
2	Possible de novo clear cell carcinoma in the contralateral ovary 9 years after fertility-sparing surgery for Stage IA clear cell ovarian carcinoma. ⁶²	Nishida K...Satoh T	31149470	2017
3	Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary. ⁶²	Shimura K...Okubo T	27987343	2017
4	Borderline Clear Cell Adenofibroma of the Ovary. ⁶²	Kleebkaow P...Kietpeerakool C	28465851	2017
5	Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes. ⁶²	Kato H...Matsuo M	27167231	2016
6	Yolk sac tumours of the female genital tract in older adults derive commonly from somatic epithelial neoplasms: somatically derived yolk sac tumours. ⁶²	McNamee T...McCluggage WG	27334714	2016
7	Effect of ARID1A/BAF250a expression on carcinogenesis and clinicopathological factors in pure-type clear cell adenocarcinoma of the ovary. ⁶²	Kato M...Furuya K	27699033	2016
8	Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome. ⁶²	Bartosch C...Oliva E	27340747	2016
9	Napsin A is a specific marker for ovarian clear cell adenocarcinoma. ⁶²	Yamashita Y...Takahashi S	24721826	2015
10	Clear cell adenocarcinoma arising from clear cell adenofibroma of the ovary: value of DWI and DCE-MRI. ⁶²	Takeuchi M...Harada M	24172789	2013
11	Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy. ⁶²	Chen R...Zhang Y	23153077	2013
12	Clear cell carcinoma of the ovary: is there a role of histology-specific treatment? ⁶²	Takano M...Sugiyama T	22655678	2012
13	Aberrant expression of the mammalian target of rapamycin, hypoxia-inducible factor-1α, and glucose transporter 1 in the development of ovarian clear-cell adenocarcinoma. ⁶²	Kato M...Furuya K	22498943	2012
14	Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations. ⁶²	Yamamoto S...Matsubara O	22157930	2012
15	Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas. ⁶²	Yamamoto S...Matsubara O	21983935	2012
16	Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report. ⁶²	Vasilakaki T...Manoloudaki K	22611972	2012
17	PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma. ⁶²	Yamamoto S...Matsubara O	22120431	2012
18	Primary Ovarian Clear Cell Adenofibroma of Borderline Malignancy. ⁶²	Cakir E...Nurkabul Z	28861185	2012
19	Pathogenesis of ovarian clear cell adenofibroma, atypical proliferative (borderline) tumor, and carcinoma: clinicopathologic features of tumors with endometriosis or adenofibromatous components support two related pathways of tumor development. ⁶²	Zhao C...Barner R	21479128	2011
20	Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. ⁶²	Liu JL...Huang RH	20890073	2010
21	Aberrant expression of p27(Kip1)-interacting cell-cycle regulatory proteins in ovarian clear cell carcinomas and their precursors with special consideration of two distinct multistage clear cell carcinogenetic pathways. ⁶²	Yamamoto S...Matsubara O	19855998	2009
22	An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway. ⁶²	Yamamoto S...Matsubara O	19655165	2009
23	Clear-cell adenofibroma can be a clonal precursor for clear-cell adenocarcinoma of the ovary: a possible alternative ovarian clear-cell carcinogenic pathway. ⁶²	Yamamoto S...Matsubara O	18600856	2008
24	Expression of platelet-derived growth factors and their receptors in ovarian clear-cell carcinoma and its putative precursors. ⁶²	Yamamoto S...Matsubara O	18084257	2008
25	Benign clear cell adenofibroma of the ovary. A case report with literature review. ⁶²	Pasaoglu O...Acikalin MF	17202822	2007
26	Unexpected gynecologic neoplasms in patients with proven or suspected BRCA-1 or -2 mutations: implications for gross examination, cytology, and clinical follow-up. ⁶²	Agoff SN...Garcia RL	11812938	2002
27	Tubulocystic ovarian clear cell carcinoma with abundant fibrous stroma: malignant clear cell adenofibroma. ⁶²	Chan YJ...Ling F	10645058	2000
28	A pregnant woman with clear cell adenocarcinoma of the ovary arising from endometriosis and with benign and borderline adenofibroma of the clear cell and endometrioid types. ⁶²	Sugiyama T...Yakushiji M	9076421	1997
29	Ovarian clear cell adenofibroma of borderline malignancy. A case report. ⁶²	Katsube Y...Fujiwara A	2793520	1989
30	Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma. ⁶²	Roth LM...Czernobilsky B	6692303	1984

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Genes for Clear Cell Adenofibroma

Genes related to Clear Cell Adenofibroma (0 elite genes):

(showing 9, show less)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	6.31	DISEASES inferred ¹⁴
2	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5.28	DISEASES inferred ¹⁴
3	KRCC1	Lysine Rich Coiled-Coil 1	Protein Coding	5.11	DISEASES inferred ¹⁴
4	NAPSA	Napsin A Aspartic Peptidase	Protein Coding	4.62	DISEASES inferred ¹⁴
5	SMARCA4	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4	Protein Coding	4.56	DISEASES inferred ¹⁴
6	BICRAL	BICRA Like Chromatin Remodeling Complex Associated Protein	Protein Coding	4.47	DISEASES inferred ¹⁴
7	CKS1B	CDC28 Protein Kinase Regulatory Subunit 1B	Protein Coding	4.43	DISEASES inferred ¹⁴
8	UBE2R2	Ubiquitin Conjugating Enzyme E2 R2	Protein Coding	4.32	DISEASES inferred ¹⁴
9	PBRM1	Polybromo 1	Protein Coding	4.22	DISEASES inferred ¹⁴

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Variations for Clear Cell Adenofibroma

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Expression for Clear Cell Adenofibroma

Search GEO for disease gene expression data for Clear Cell Adenofibroma.

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Pathways for Clear Cell Adenofibroma

Pathways related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(showing 4, show less)

#	Super pathways	Score	Top Affiliating Genes
1	Transcription Ligand-dependent activation of the ESR1/SP pathway ²² Show member pathways Development Ligand-dependent activation of the ESR1/AP-1 pathway ²²	11.1	SMARCA4 ARID1A
2	Pathways affected in adenoid cystic carcinoma ⁷⁴	10.95	PIK3CA ARID1A
3	Tumor suppressor activity of SMARCB1 ⁷⁴ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶	10.49	SMARCA4 ARID1A
4	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ⁶⁶	10.38	SMARCA4 PBRM1 ARID1A

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GO Terms for Clear Cell Adenofibroma

Cellular components related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(showing 8, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	nBAF complex	GO:0071565	9.73	SMARCA4 ARID1A
2	RSC-type complex	GO:0016586	9.71	SMARCA4 PBRM1
3	GBAF complex	GO:0140288	9.67	SMARCA4 BICRAL
4	npBAF complex	GO:0071564	9.62	SMARCA4 ARID1A
5	bBAF complex	GO:0140092	9.56	SMARCA4 ARID1A
6	SWI/SNF complex	GO:0016514	9.23	SMARCA4 PBRM1 BICRAL ARID1A
7	DNA packaging complex	GO:0044815	9.16	SMARCA4 ARID1A
8	SWI/SNF superfamily-type complex	GO:0070603	8.96	SMARCA4 ARID1A

Biological processes related to Clear Cell Adenofibroma according to GeneCards Suite gene sharing:

(showing 11, show less)

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin remodeling	GO:0006338	10.03	SMARCA4 PBRM1 BICRAL ARID1A
2	positive regulation of cell differentiation	GO:0045597	9.95	SMARCA4 PBRM1 ARID1A
3	regulation of G1/S transition of mitotic cell cycle	GO:2000045	9.93	SMARCA4 PBRM1 ARID1A
4	positive regulation of stem cell population maintenance	GO:1902459	9.88	SMARCA4 BICRAL ARID1A
5	positive regulation of myoblast differentiation	GO:0045663	9.85	ARID1A PBRM1 SMARCA4
6	nucleosome disassembly	GO:0006337	9.8	SMARCA4 ARID1A
7	positive regulation of double-strand break repair	GO:2000781	9.8	SMARCA4 PBRM1 ARID1A
8	positive regulation of T cell differentiation	GO:0045582	9.73	SMARCA4 PBRM1 ARID1A
9	regulation of mitotic metaphase/anaphase transition	GO:0030071	9.63	SMARCA4 PBRM1 ARID1A
10	regulation of nucleotide-excision repair	GO:2000819	9.43	SMARCA4 PBRM1 ARID1A
11	regulation of G0 to G1 transition	GO:0070316	9.1	SMARCA4 PBRM1 ARID1A

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Sources for Clear Cell Adenofibroma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CLR012 MIFTS: 25	Clear Cell Adenofibroma Categories: Cancer diseases	Data Licensing For inquiries, contact: [email protected]
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