MCID: CLR014
MIFTS: 24

Clear Cell Adenoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Clear Cell Adenoma

MalaCards integrated aliases for Clear Cell Adenoma:

Name: Clear Cell Adenoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5390
NCIt 49 C4151
SNOMED-CT 67 1752006
UMLS 71 C0334315

Summaries for Clear Cell Adenoma

Disease Ontology : 12 An adenoma that is composed of cells with a clear cytoplasm located in ovary.

MalaCards based summary : Clear Cell Adenoma is related to water-clear cell adenoma and parathyroid adenoma. An important gene associated with Clear Cell Adenoma is PTH (Parathyroid Hormone), and among its related pathways/superpathways is Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include ovary, bone and thyroid, and related phenotypes are limbs/digits/tail and skeleton

Related Diseases for Clear Cell Adenoma

Diseases related to Clear Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 water-clear cell adenoma 34.1 PTH HOOK1
2 parathyroid adenoma 30.5 PTH CDC73
3 osteitis fibrosa 30.1 PTH CDC73
4 parathyroid carcinoma 30.0 PTH CDC73
5 primary hyperparathyroidism 30.0 PTH CDC73
6 parathyroid transitional clear cell adenoma 12.6
7 epithelial-myoepithelial carcinoma 11.9
8 adenoma 10.6
9 hyperparathyroidism 10.3
10 substernal goiter 10.3 TG PTH
11 postsurgical hypothyroidism 10.3 TG PTH
12 tall cell variant papillary carcinoma 10.3 TG PTH
13 endemic goiter 10.2 TG PTH
14 nontoxic goiter 10.2 TG PTH
15 hypothyroidism, congenital, nongoitrous, 1 10.2 TG PTH
16 hypocalciuric hypercalcemia, familial, type i 10.2 PTH CDC73
17 graves disease 1 10.2 TG PTH
18 hypocalciuric hypercalcemia, familial, type ii 10.2 PTH CDC73
19 bone benign neoplasm 10.2 PTH CDC73
20 familial hypocalciuric hypercalcemia 10.2 PTH CDC73
21 ossifying fibroma 10.2 PTH CDC73
22 autoimmune disease of endocrine system 10.2 TG PTH
23 papillary carcinoma 10.2 TG S100A1
24 connective tissue benign neoplasm 10.2 PTH CDC73
25 multinodular goiter 10.1 TG PTH
26 multiple endocrine neoplasia, type iia 10.1 PTH CDC73
27 mineral metabolism disease 10.1 PTH CDC73
28 rare tumor 10.1
29 fibroma 10.1 S100A1 CDC73
30 parathyroid gland disease 10.0 TG PTH CDC73
31 endocrine organ benign neoplasm 9.9 TG PTH CDC73
32 cutaneous fibrous histiocytoma 9.9 S100A1 KITLG
33 myoepithelioma 9.9 S100A1 KITLG
34 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9 TG KITLG
35 giant cell reparative granuloma 9.9 PTH CALCR
36 hypercalcemia, infantile, 1 9.9
37 constipation 9.9
38 acromegaly 9.9
39 bone inflammation disease 9.9
40 pleomorphic adenoma 9.9
41 follicular adenoma 9.9
42 adrenal adenoma 9.9
43 back pain 9.9
44 posttransplant acute limbic encephalitis 9.9
45 thyroid tumor 9.9
46 bone giant cell tumor 9.8 PTH CALCR
47 neurofibroma 9.8 S100A1 KITLG
48 mucoepidermoid carcinoma 9.8 TG S100A1
49 calcinosis 9.8 PTH KITLG
50 thyroid carcinoma, familial medullary 9.8 TG CALCR

Graphical network of the top 20 diseases related to Clear Cell Adenoma:



Diseases related to Clear Cell Adenoma

Symptoms & Phenotypes for Clear Cell Adenoma

MGI Mouse Phenotypes related to Clear Cell Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 CALCR KITLG PTH TG
2 skeleton MP:0005390 9.02 CALCR CDC73 KITLG PTH TG

Drugs & Therapeutics for Clear Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Adenoma

Genetic Tests for Clear Cell Adenoma

Anatomical Context for Clear Cell Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Clear Cell Adenoma:

19
Ovary

MalaCards organs/tissues related to Clear Cell Adenoma:

40
Ovary, Bone, Thyroid, Salivary Gland, Adrenal Gland, Colon, Kidney

Publications for Clear Cell Adenoma

Articles related to Clear Cell Adenoma:

(show top 50) (show all 51)
# Title Authors PMID Year
1
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland. 61
28832084 2019
2
Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia. 61
28888222 2017
3
Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism. 61
28382826 2017
4
An unusual cause of hypercalcemic crisis: Water-clear cell double parathyroid adenoma. 61
29260127 2017
5
Abdominal tuberculosis that masked under the early postoperative septic complications. 61
27657822 2016
6
Intrathyroidal Clear Cell Tumor of Parathyroid Origin with Review of Literature. 61
28003924 2016
7
Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. 61
23539328 2014
8
Cytologic findings of a clear cell parathyroid lesion. 61
22144114 2013
9
Water-clear cell adenoma: A rare form of hyperparathyroidism. 61
23995477 2013
10
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. 61
19235130 2010
11
Clear cell change in colonic polyps. 61
18611940 2009
12
Central pancreatectomy without anastomosis. 61
19719851 2009
13
Clear-cell adenoma of the fallopian tube, a rare tumor of the tubal mucosa. 61
15141314 2004
14
A rare case of primary hyperparathyroidism with clear cell adenoma. 61
15118272 2004
15
Signet-ring follicular adenoma of the thyroid diagnosed by fine needle aspiration. Report of a case with cytologic description. 61
14969188 2004
16
Water-clear cell adenoma of the parathyroid gland: a rare entity. 61
15471124 2004
17
Expression of parathyroid hormone-related protein (PTHrP) in parathyroid tissue under normal and pathological conditions. 61
11813867 2002
18
Thyroid clear cell adenoma with marked dilatation of membranous structures: electron-microscopic study. 61
11758717 2001
19
Intrathyroidal water-clear cell parathyroid adenoma: a case report. 61
11521237 2001
20
[Clear cell adenoma of the parathyroid gland: a rare and misleading lesion]. 61
10544768 1999
21
Clear cell tumors of the salivary glands, jaws, and oral mucosa. 61
9279976 1997
22
Lipomatous Changes in Adrenocortical Adenomas: Report of Two Cases. 61
12114735 1996
23
Water-clear cell 'adenoma'. A new entity in the pathology of primary hyperparathyroidism. 61
7487416 1995
24
Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. 61
7487410 1995
25
Large clear cell adenoma of the parathyroid in a patient with MEN-1 syndrome. Ultrastructural study of the tumour exhibiting unusual RER formations. 61
7725822 1994
26
Lipid-rich adenoma of the thyroid. 61
8302729 1993
27
Epithelial-myoepithelial carcinoma of salivary glands. 61
2045502 1991
28
[Epithelial-myoepithelial tumor of the salivary gland. Cytologic and histologic features]. 61
1845399 1991
29
Renal carcinoma metastasis to the parotid gland. 61
2370461 1990
30
Immunohistochemical study of basal cell adenoma in the parotid gland. 61
2133439 1990
31
The nucleolar organizer regions associated protein (Ag-NORs) in salivary gland tumors. 61
2473144 1989
32
[Renal clear cell tumors: morphology, histochemistry, ultrastructure, differential diagnosis]. 61
2742516 1989
33
A case of glucocorticoid-suppressible hyperaldosteronism with aldosterone producing adenoma. 61
3208706 1988
34
[Ultrastructural and immunohistochemical studies on pleomorphic adenoma and clear cell adenoma arising from salivary gland]. 61
2855893 1988
35
Clear-cell epithelial neoplasms of the large intestine. 61
3276291 1988
36
Immunohistochemical localization by monoclonal antibody of human epidermal growth factor in mixed tumours of the skin. 61
2832458 1987
37
[Similarity and differences of the pathogenesis of Itsenko-Cushing syndrome variants]. 61
3027692 1986
38
[Solid clear-cell adenoma in a simple kidney cyst]. 61
3992761 1985
39
Distribution of S-100b protein in normal salivary glands and salivary gland tumors. 61
6314639 1983
40
[Clear cell adenoma of the parotid. Anatomo-clinical consideration apropos of a case]. 61
6211506 1982
41
[Clear-cell adenoma of the larynx]. 61
7376321 1980
42
[Morphology of the Fahr syndrome (idiopathic calcification of the cerebral vessels)]. 61
526168 1979
43
[So-called clear-cell adenoma in the gingival region of the mandible--report of a case (author's transl)]. 61
268387 1977
44
[Clear-cell adenoma of the thyroid gland (author's transl)]. 61
4203386 1973
45
Parotid clear-cell adenoma of possible myoepithelial origin. 61
5075358 1972
46
A comparative study of steroid biosyntheses in vitro. In clear cell adenoma and its adjacent tissue of human adrenal gland. 61
4241746 1969
47
[A case of clear cell adenoma with calcified capsule]. 61
5711504 1968
48
Corticosteroid synthesis in a clear cell adenoma: a time-based study. 61
4885809 1968
49
A comparison of the conversion in vitro of pregnenolone sulphate and pregnenolone to steroid hormones by tissue from a clear cell adenoma of the adrenal gland. 61
5635101 1968
50
[Data on a case of osteitis fibrosa cystica caused by clear cell adenoma of the parathyroid]. 61
13457715 1957

Variations for Clear Cell Adenoma

Expression for Clear Cell Adenoma

Search GEO for disease gene expression data for Clear Cell Adenoma.

Pathways for Clear Cell Adenoma

Pathways related to Clear Cell Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.28 PTH CALCR

GO Terms for Clear Cell Adenoma

Sources for Clear Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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