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MCID: CLR015
MIFTS: 21

Clear Cell Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Clear Cell Basal Cell Carcinoma

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MalaCards integrated aliases for Clear Cell Basal Cell Carcinoma:

Name: Clear Cell Basal Cell Carcinoma 12 15
Skin Clear Cell Basal Cell Carcinoma 12 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4293
NCIt 50 C27536
UMLS 73 C1516599
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Summaries for Clear Cell Basal Cell Carcinoma

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MalaCards based summary : Clear Cell Basal Cell Carcinoma, also known as skin clear cell basal cell carcinoma, is related to basal cell carcinoma and basal cell carcinoma 1. An important gene associated with Clear Cell Basal Cell Carcinoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin.

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Related Diseases for Clear Cell Basal Cell Carcinoma

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Diseases related to Clear Cell Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 28.8 KRT17 KRT7
2 basal cell carcinoma 1 10.3
3 inverted follicular keratosis 9.9 CLEC2A KRT17
4 malignant syringoma 9.5 KRT17 KRT7
5 large cell acanthoma 9.5 KRT17 KRT7
6 bowen's disease 9.5 KRT17 KRT7
7 ampulla of vater neoplasm 9.5 KRT17 KRT7
8 ampulla of vater adenocarcinoma 9.4 KRT17 KRT7
9 ovarian mucinous neoplasm 9.4 KRT17 KRT7
10 basaloid squamous cell carcinoma 9.4 KRT17 KRT7
11 integumentary system cancer 9.3 CLEC2A KRT7
12 primary cutaneous amyloidosis 9.3 KRT17 KRT7
13 polycystic liver disease 1 with or without kidney cysts 9.1 KRT17 KRT7
14 infiltrative basal cell carcinoma 8.9 CLEC2A KRT17 KRT7

Graphical network of the top 20 diseases related to Clear Cell Basal Cell Carcinoma:



Diseases related to Clear Cell Basal Cell Carcinoma
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Symptoms & Phenotypes for Clear Cell Basal Cell Carcinoma

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Drugs & Therapeutics for Clear Cell Basal Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Clear Cell Basal Cell Carcinoma

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Genetic Tests for Clear Cell Basal Cell Carcinoma

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Anatomical Context for Clear Cell Basal Cell Carcinoma

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MalaCards organs/tissues related to Clear Cell Basal Cell Carcinoma:

41
Skin
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Publications for Clear Cell Basal Cell Carcinoma

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Articles related to Clear Cell Basal Cell Carcinoma:

# Title Authors Year
1
Clear cell Basal cell carcinoma. ( 21559201 )
2011
2
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review. ( 21048492 )
2011
3
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. ( 17414450 )
2007
4
Clear cell basal cell carcinoma with sialomucin deposition. ( 17191318 )
2006
5
Clear-cell basal cell carcinoma of the upper eyelid: a case report. ( 10454334 )
1999
6
Clear cell basal cell carcinoma: an unusual degenerative variant. ( 8227606 )
1993
7
Clear cell basal cell carcinoma. ( 1706297 )
1990
8
Signet-ring clear-cell basal cell carcinoma. ( 2456318 )
1988
9
Clear-cell, basal cell carcinoma: histopathological, histochemical, and electron microscopic findings. ( 3221000 )
1988
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Variations for Clear Cell Basal Cell Carcinoma

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Cosmic variations for Clear Cell Basal Cell Carcinoma:

9
(show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 7
2 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 7
3 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 7
4 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 7
5 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 7
6 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 7
7 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 7
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 7
9 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 7
10 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 7
11 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 7
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 7
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 7
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 7
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 7
16 COSM44096 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>G p.P250A 17:7674215-7674215 7
17 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 7
18 COSM45169 TP53 skin,NS,carcinoma,basal cell carcinoma c.326T>C p.F109S 17:7676043-7676043 7
19 COSM43842 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 7
20 COSM43695 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 7
21 COSM10988 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 7
22 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 7
23 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 7
24 COSM43778 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 7
25 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 7
26 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 7
27 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 7
28 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 7
29 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 7
30 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 7
31 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 7
32 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 7
33 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 7
34 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 7
35 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 7
36 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 7
37 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 7
38 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 7
39 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 7
40 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 7
41 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 7
42 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 7
43 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 7
44 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 7
45 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 7
46 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 7
47 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 7
48 COSM44552 TP53 skin,NS,carcinoma,basal cell carcinoma c.509C>T p.T170M 17:7675103-7675103 7
49 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 7
50 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 7
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Expression for Clear Cell Basal Cell Carcinoma

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Search GEO for disease gene expression data for Clear Cell Basal Cell Carcinoma.
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Pathways for Clear Cell Basal Cell Carcinoma

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Pathways related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.64 KRT17 KRT7
2
Keratinization 66
Show member pathways
 11.41 KRT17 KRT7
3
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.66 KRT17 KRT7
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GO Terms for Clear Cell Basal Cell Carcinoma

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Cellular components related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT17 KRT7

Biological processes related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT17 KRT7
2 cornification GO:0070268 8.62 KRT17 KRT7

Molecular functions related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 KRT17 KRT7
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Sources for Clear Cell Basal Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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