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MCID: CLR015
MIFTS: 40

Clear Cell Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Clear Cell Basal Cell Carcinoma

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MalaCards integrated aliases for Clear Cell Basal Cell Carcinoma:

Name: Clear Cell Basal Cell Carcinoma 12 15
Skin Clear Cell Basal Cell Carcinoma 12 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4293
NCIt 49 C27536
UMLS 71 C1516599
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Summaries for Clear Cell Basal Cell Carcinoma

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MalaCards based summary : Clear Cell Basal Cell Carcinoma, also known as skin clear cell basal cell carcinoma, is related to basal cell carcinoma and inverted transitional papilloma. An important gene associated with Clear Cell Basal Cell Carcinoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include breast, skin and colon, and related phenotypes are cellular and growth/size/body region

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Related Diseases for Clear Cell Basal Cell Carcinoma

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Diseases related to Clear Cell Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 409)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 28.4 TP53 PTCH1 PHLDA1 KRT7 KRT5 KRT20
2 inverted transitional papilloma 10.6 KRT7 KRT5
3 ceruminoma 10.6 KRT7 KRT5
4 subareolar duct papillomatosis 10.6 KRT7 KRT5
5 proliferating trichilemmal cyst 10.6 KRT7 KRT19
6 bone leiomyosarcoma 10.6 KRT7 KRT5
7 nipple neoplasm 10.6 KRT7 KRT5
8 microinvasive cervical squamous cell carcinoma 10.5 KRT7 KRT5
9 breast hemangiopericytoma 10.5 KRT7 KRT19
10 ovarian mesodermal adenosarcoma 10.5 MYOG KRT7
11 gastric squamous cell carcinoma 10.5 KRT7 KRT5
12 pancreatic serous cystadenocarcinoma 10.5 KRT7 KRT20
13 nephrogenic adenoma of urinary bladder 10.5 KRT7 KRT20
14 breast cystic hypersecretory carcinoma 10.5 KRT5 CEACAM5
15 breast mucinous carcinoma 10.5 KRT7 KRT5
16 gallbladder squamous cell carcinoma 10.5 KRT5 CEACAM5
17 atrophic vulva 10.5 KRT7 KRT20
18 cutaneous mucoepidermoid carcinoma 10.5 KRT7 CEACAM5
19 mediastinum sarcoma 10.5 KRT7 KRT19
20 sarcomatoid squamous cell skin carcinoma 10.5 MYOG KRT5
21 malignant epithelial mesothelioma 10.5 KRT5 CEACAM5
22 vulva basal cell carcinoma 10.5 KRT5 CEACAM5
23 malignant sertoli-leydig cell tumor 10.5 MYOG CEACAM5
24 middle ear adenocarcinoma 10.5 KRT7 KRT5
25 eyelid carcinoma 10.5 KRT7 KRT20
26 apocrine adenoma 10.5 KRT7 CEACAM5
27 vulval paget's disease 10.5 KRT7 CEACAM5
28 sigmoid neoplasm 10.5 KRT7 CEACAM5
29 ovarian germ cell teratoma 10.5 KRT7 KRT19
30 papillary squamous carcinoma 10.5 KRT7 KRT5
31 eccrine adenocarcinoma 10.5 KRT7 CEACAM5
32 pericardial mesothelioma 10.5 KRT5 KRT19
33 jejunal neoplasm 10.5 KRT7 KRT20
34 balloon cell malignant melanoma 10.5 KRT7 KRT5
35 ovarian brenner tumor 10.5 KRT7 KRT20
36 breast papillary carcinoma 10.5 KRT5 CHGA
37 acinar cell cystadenocarcinoma 10.5 KRT19 CHGA
38 auditory system cancer 10.5 KRT7 CHGA
39 pilar sheath acanthoma 10.5 PHLDA1 CLEC2A
40 myoblastoma 10.5 MYOG CEACAM5
41 vaginal glandular tumor 10.4 CHGA CEACAM5
42 epididymis adenocarcinoma 10.4 KRT7 KRT5
43 renal adenoma 10.4 KRT7 KRT19
44 epididymis cancer 10.4 KRT7 KRT5
45 pancreas lymphoma 10.4 CHGA CEACAM5
46 vulvar eccrine porocarcinoma 10.4 CHGA CEACAM5
47 goblet cell carcinoid 10.4 KRT20 CHGA
48 intrahepatic gall duct cancer 10.4 KRT7 KRT19 KRT17
49 cervical neuroblastoma 10.4 MYOG CHGA
50 warthin tumor 10.4 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Clear Cell Basal Cell Carcinoma:



Diseases related to Clear Cell Basal Cell Carcinoma
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Symptoms & Phenotypes for Clear Cell Basal Cell Carcinoma

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MGI Mouse Phenotypes related to Clear Cell Basal Cell Carcinoma:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.25 CDX2 EHD4 KRT14 KRT17 KRT19 KRT7
2 growth/size/body region MP:0005378 10.22 CDX2 CHGA EHD4 KIAA1109 KRT14 KRT17
3 digestive/alimentary MP:0005381 10.13 CDX2 KRT14 KRT17 KRT19 KRT5 PAX3
4 mortality/aging MP:0010768 10.13 CDX2 CHGA EHD4 KIAA1109 KRT14 KRT17
5 craniofacial MP:0005382 10.1 KRT14 KRT17 KRT19 KRT5 PAX3 PAX7
6 endocrine/exocrine gland MP:0005379 10.09 CDX2 CHGA EHD4 KRT14 KRT19 PAX3
7 integument MP:0010771 10.07 KIAA1109 KRT14 KRT17 KRT19 KRT5 MYOG
8 embryo MP:0005380 10.06 CDX2 KIAA1109 KRT19 MYOG PAX3 PAX7
9 no phenotypic analysis MP:0003012 9.85 CHGA EHD4 KRT17 KRT19 KRT5 MYOG
10 neoplasm MP:0002006 9.8 CDX2 KRT14 KRT19 PAX3 PAX7 PTCH1
11 pigmentation MP:0001186 9.35 KRT14 KRT17 PAX3 PTCH1 TP53
12 respiratory system MP:0005388 9.17 KRT14 KRT19 MYOG PAX3 PAX7 PTCH1
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Drugs & Therapeutics for Clear Cell Basal Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Clear Cell Basal Cell Carcinoma

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Genetic Tests for Clear Cell Basal Cell Carcinoma

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Anatomical Context for Clear Cell Basal Cell Carcinoma

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MalaCards organs/tissues related to Clear Cell Basal Cell Carcinoma:

40
Breast, Skin, Colon, Lung, Ovary, Thymus, Liver
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Publications for Clear Cell Basal Cell Carcinoma

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Articles related to Clear Cell Basal Cell Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Solid Microcystic Adnexal Carcinoma on the Thigh: An Unusual Location. 61
31436574 2020
2
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. 61
31319387 2019
3
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review. 61
21048492 2011
4
Clear cell Basal cell carcinoma. 61
21559201 2011
5
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. 61
17414450 2007
6
Clear cell basal cell carcinoma with sialomucin deposition. 61
17191318 2006
7
Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis. 61
12641780 2003
8
Clear-cell basal cell carcinoma of the upper eyelid: a case report. 61
10454334 1999
9
Clear cell basal cell carcinoma: an unusual degenerative variant. 61
8227606 1993
10
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations. 61
1591688 1992
11
Clear cell basal cell carcinoma. 61
1706297 1990
12
Clear-cell, basal cell carcinoma: histopathological, histochemical, and electron microscopic findings. 61
3221000 1988
13
Signet-ring clear-cell basal cell carcinoma. 61
2456318 1988
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Variations for Clear Cell Basal Cell Carcinoma

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Cosmic variations for Clear Cell Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
2 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
3 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
4 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
5 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
6 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
7 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
8 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
9 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
10 COSM87027025 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
11 COSM87028684 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
12 COSM90144180 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 3
13 COSM88644633 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 3
14 COSM87925664 TP53 skin,NS,carcinoma,basal cell carcinoma c.477C>T p.A159= 17:7675135-7675135 3
15 COSM87919454 TP53 skin,NS,carcinoma,basal cell carcinoma c.395A>T p.K132M 17:7675217-7675217 3
16 COSM88272290 TP53 skin,NS,carcinoma,basal cell carcinoma c.480G>C p.M160I 17:7675132-7675132 3
17 COSM87898709 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 3
18 COSM87910628 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 3
19 COSM88387703 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 3
20 COSM87963219 TP53 skin,NS,carcinoma,basal cell carcinoma c.292C>T p.P98S 17:7676077-7676077 3
21 COSM87929396 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 3
22 COSM87898723 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
23 COSM88310572 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 3
24 COSM87898714 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 3
25 COSM87898991 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 3
26 COSM88408340 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 3
27 COSM87906968 TP53 skin,NS,carcinoma,basal cell carcinoma c.833C>T p.P278L 17:7673787-7673787 3
28 COSM87910495 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 3
29 COSM87899497 TP53 skin,NS,carcinoma,basal cell carcinoma c.586C>T p.R196* 17:7674945-7674945 3
30 COSM87906130 TP53 skin,NS,carcinoma,basal cell carcinoma c.854A>T p.E285V 17:7673766-7673766 3
31 COSM87919200 TP53 skin,NS,carcinoma,basal cell carcinoma c.511G>C p.E171Q 17:7675101-7675101 3
32 COSM87944274 TP53 skin,NS,carcinoma,basal cell carcinoma c.419C>T p.T140I 17:7675193-7675193 3
33 COSM87921224 TP53 skin,NS,carcinoma,basal cell carcinoma c.835G>A p.G279R 17:7673785-7673785 3
34 COSM87898567 TP53 skin,NS,carcinoma,basal cell carcinoma c.748C>T p.P250S 17:7674215-7674215 3
35 COSM87900980 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 3
36 COSM87947692 TP53 skin,NS,carcinoma,basal cell carcinoma c.770T>C p.L257P 17:7674193-7674193 3
37 COSM87957813 TP53 skin,NS,carcinoma,basal cell carcinoma c.737T>G p.M246R 17:7674226-7674226 3
38 COSM87904406 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 3
39 COSM87917387 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 3
40 COSM87932688 TP53 skin,NS,carcinoma,basal cell carcinoma c.507G>A p.M169I 17:7675105-7675105 3
41 COSM87903307 TP53 skin,NS,carcinoma,basal cell carcinoma c.841G>A p.D281N 17:7673779-7673779 3
42 COSM87905687 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 3
43 COSM87899661 TP53 skin,NS,carcinoma,basal cell carcinoma c.797G>A p.G266E 17:7673823-7673823 3
44 COSM87908365 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 3
45 COSM87961406 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 3
46 COSM87918616 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 3
47 COSM87897745 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 3
48 COSM87911563 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 3
49 COSM87922049 TP53 skin,NS,carcinoma,basal cell carcinoma c.713G>T p.C238F 17:7674250-7674250 3
50 COSM87898431 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 3
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Expression for Clear Cell Basal Cell Carcinoma

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Search GEO for disease gene expression data for Clear Cell Basal Cell Carcinoma.
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Pathways for Clear Cell Basal Cell Carcinoma

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Pathways related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
12.21 KRT7 KRT5 KRT20 KRT19 KRT17
2
Keratinization 65
Show member pathways
 11.89 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14
3
Staphylococcus aureus infection 36
11.54 KRT20 KRT19 KRT17 KRT14
4
Glucocorticoid receptor regulatory network 1
11.37 TP53 KRT5 KRT17 KRT14
5
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 11.05 KRT7 KRT5 KRT19 KRT17 KRT14
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GO Terms for Clear Cell Basal Cell Carcinoma

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Cellular components related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.33 KRT7 KRT5 KRT14
2 cell periphery GO:0071944 9.13 KRT19 KRT17 KRT14
3 intermediate filament GO:0005882 9.1 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Biological processes related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 TP53 PTCH1 PAX3 MYOG CDX2
2 muscle organ development GO:0007517 9.54 PAX7 PAX3 MYOG
3 epidermis development GO:0008544 9.46 PTCH1 KRT5 KRT17 KRT14
4 keratinization GO:0031424 9.43 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14
5 dorsal/ventral neural tube patterning GO:0021904 9.32 PTCH1 PAX7
6 hemidesmosome assembly GO:0031581 9.26 KRT5 KRT14
7 cornification GO:0070268 9.1 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Molecular functions related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.02 KRT5 KRT20 KRT19 KRT17 KRT14
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Sources for Clear Cell Basal Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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