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MCID: CLR015
MIFTS: 30

Clear Cell Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for Clear Cell Basal Cell Carcinoma

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MalaCards integrated aliases for Clear Cell Basal Cell Carcinoma:

Name: Clear Cell Basal Cell Carcinoma 12 15
Skin Clear Cell Basal Cell Carcinoma 12 72

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4293
NCIt 50 C27536
UMLS 72 C1516599
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Summaries for Clear Cell Basal Cell Carcinoma

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MalaCards based summary : Clear Cell Basal Cell Carcinoma, also known as skin clear cell basal cell carcinoma, is related to nodular basal cell carcinoma and basal cell carcinoma. An important gene associated with Clear Cell Basal Cell Carcinoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include skin.

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Related Diseases for Clear Cell Basal Cell Carcinoma

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Diseases related to Clear Cell Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 nodular basal cell carcinoma 30.4 PTCH1 KRT17
2 basal cell carcinoma 29.3 PTCH1 KRT7 KRT19 KRT17
3 inverted follicular keratosis 10.3 KRT17 CLEC2A
4 large cell acanthoma 10.3 KRT7 KRT17
5 bowen's disease 10.2 KRT7 KRT17
6 pigmented basal cell carcinoma 10.2 PTCH1 CLEC2A
7 ampulla of vater adenocarcinoma 10.2 KRT7 KRT17
8 ovarian mucinous neoplasm 10.2 KRT7 KRT17
9 brooke-spiegler syndrome 10.2 PTCH1 KRT7
10 eccrine sweat gland neoplasm 10.2 KRT7 KRT17
11 basal cell carcinoma, infundibulocystic 10.2 PHLDA1 KRT17
12 basaloid squamous cell carcinoma 10.2 KRT7 KRT17
13 ampulla of vater cancer 10.1 KRT7 KRT17
14 malignant acrospiroma 10.1 PHLDA1 CLEC2A
15 focal dermal hypoplasia 10.0
16 superior mesenteric artery syndrome 9.9 KRT19 KRT17
17 malignant struma ovarii 9.9 PTCH1 KRT19
18 intrahepatic bile duct adenoma 9.9 KRT7 KRT19
19 proliferating trichilemmal cyst 9.9 KRT7 KRT19
20 anal gland adenocarcinoma 9.9 KRT7 KRT19
21 anus adenocarcinoma 9.9 KRT7 KRT19
22 renal pelvis adenocarcinoma 9.9 KRT7 KRT19
23 cutaneous adenocystic carcinoma 9.9 KRT7 KRT19
24 bladder carcinoma in situ 9.9 KRT7 KRT19
25 malignant leydig cell tumor 9.9 KRT7 KRT19
26 eccrine adenocarcinoma 9.8 KRT7 KRT19
27 corneal abscess 9.8 KRT7 KRT19
28 anal canal adenocarcinoma 9.8 KRT7 KRT19
29 chondroid lipoma 9.8 KRT7 KRT19
30 renal pelvis carcinoma 9.8 KRT7 KRT19
31 biliary papillomatosis 9.8 KRT7 KRT19
32 brachydactyly, type e1 9.8 PTCH1 KRT19
33 mucinous tubular and spindle renal cell carcinoma 9.8 KRT7 KRT19
34 lipoadenoma 9.8 KRT7 KRT19
35 infiltrative basal cell carcinoma 9.8 KRT7 KRT17 CLEC2A
36 thymus lipoma 9.8 KRT7 KRT19
37 immune system organ benign neoplasm 9.8 KRT7 KRT19
38 pericardium cancer 9.8 KRT7 KRT19
39 intraneural perineurioma 9.7 KRT7 KRT19
40 pericardial mesothelioma 9.7 KRT7 KRT19
41 bile duct adenocarcinoma 9.7 KRT7 KRT19
42 white sponge nevus 1 9.7 KRT7 KRT19
43 bile duct disease 9.7 KRT7 KRT19
44 biliary tract disease 9.7 KRT7 KRT19
45 sarcoma, synovial 9.6 KRT7 KRT19
46 chordoma 9.6 KRT7 KRT19
47 papillary carcinoma 9.6 KRT7 KRT19
48 intrahepatic cholangiocarcinoma 9.5 KRT7 KRT19
49 pregnancy adenoma 9.5 KRT7 KRT19 KRT17
50 primary cutaneous amyloidosis 9.5 KRT7 KRT19 KRT17

Graphical network of the top 20 diseases related to Clear Cell Basal Cell Carcinoma:



Diseases related to Clear Cell Basal Cell Carcinoma
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Symptoms & Phenotypes for Clear Cell Basal Cell Carcinoma

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Drugs & Therapeutics for Clear Cell Basal Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Clear Cell Basal Cell Carcinoma

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Genetic Tests for Clear Cell Basal Cell Carcinoma

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Anatomical Context for Clear Cell Basal Cell Carcinoma

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MalaCards organs/tissues related to Clear Cell Basal Cell Carcinoma:

41
Skin
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Publications for Clear Cell Basal Cell Carcinoma

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Articles related to Clear Cell Basal Cell Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Solid Microcystic Adnexal Carcinoma on the Thigh: An Unusual Location. 38
31436574 2019
2
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. 38
31319387 2019
3
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review. 38
21048492 2011
4
Clear cell Basal cell carcinoma. 38
21559201 2011
5
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. 38
17414450 2007
6
Clear cell basal cell carcinoma with sialomucin deposition. 38
17191318 2006
7
Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis. 38
12641780 2003
8
Clear-cell basal cell carcinoma of the upper eyelid: a case report. 38
10454334 1999
9
Clear cell basal cell carcinoma: an unusual degenerative variant. 38
8227606 1993
10
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations. 38
1591688 1992
11
Clear cell basal cell carcinoma. 38
1706297 1990
12
Clear-cell, basal cell carcinoma: histopathological, histochemical, and electron microscopic findings. 38
3221000 1988
13
Signet-ring clear-cell basal cell carcinoma. 38
2456318 1988
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Variations for Clear Cell Basal Cell Carcinoma

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Cosmic variations for Clear Cell Basal Cell Carcinoma:

9 (show top 50) (show all 687)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6926860 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
2 COSM6969201 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
3 COSM6953811 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
4 COSM6926862 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
5 COSM6936924 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
6 COSM3691166 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
7 COSM6926861 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
8 COSM212945 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
9 COSM6936922 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
10 COSM6926855 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
11 COSM6953809 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
12 COSM6912933 TRAF7 skin,NS,carcinoma,basal cell carcinoma c.1802C>T p.T601I 16:2176104-2176104 3
13 COSM6949578 TP63 skin,NS,carcinoma,basal cell carcinoma c.1922C>T p.A641V 3:189894381-189894381 3
14 COSM44071 TP53 skin,NS,carcinoma,basal cell carcinoma c.955A>G p.K319E 17:7673573-7673573 3
15 COSM44097 TP53 skin,NS,carcinoma,basal cell carcinoma c.530C>T p.P177L 17:7675082-7675082 3
16 COSM10812 TP53 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.S241F 17:7674241-7674241 3
17 COSM10988 TP53 skin,NS,carcinoma,basal cell carcinoma c.772G>A p.E258K 17:7674191-7674191 3
18 COSM45074 TP53 skin,NS,carcinoma,basal cell carcinoma c.829T>G p.C277G 17:7673791-7673791 3
19 COSM10728 TP53 skin,NS,carcinoma,basal cell carcinoma c.839G>A p.R280K 17:7673781-7673781 3
20 COSM45739 TP53 skin,NS,carcinoma,basal cell carcinoma c.677G>C p.G226A 17:7674286-7674286 3
21 COSM44295 TP53 skin,NS,carcinoma,basal cell carcinoma c.993+1G>A p.? 17:7673534-7673534 3
22 COSM10939 TP53 skin,NS,carcinoma,basal cell carcinoma c.832C>T p.P278S 17:7673788-7673788 3
23 COSM10650 TP53 skin,NS,carcinoma,basal cell carcinoma c.529C>T p.P177S 17:7675083-7675083 3
24 COSM10662 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 3
25 COSM43665 TP53 skin,NS,carcinoma,basal cell carcinoma c.746G>C p.R249T 17:7674217-7674217 3
26 COSM45774 TP53 skin,NS,carcinoma,basal cell carcinoma c.899C>G p.P300R 17:7673721-7673721 3
27 COSM10749 TP53 skin,NS,carcinoma,basal cell carcinoma c.830G>T p.C277F 17:7673790-7673790 3
28 COSM10660 TP53 skin,NS,carcinoma,basal cell carcinoma c.818G>A p.R273H 17:7673802-7673802 3
29 COSM11449 TP53 skin,NS,carcinoma,basal cell carcinoma c.388C>T p.L130F 17:7675224-7675224 3
30 COSM10771 TP53 skin,NS,carcinoma,basal cell carcinoma c.749C>T p.P250L 17:7674214-7674214 3
31 COSM44068 TP53 skin,NS,carcinoma,basal cell carcinoma c.532C>A p.H178N 17:7675080-7675080 3
32 COSM11152 TP53 skin,NS,carcinoma,basal cell carcinoma c.700T>C p.Y234H 17:7674263-7674263 3
33 COSM10768 TP53 skin,NS,carcinoma,basal cell carcinoma c.535C>T p.H179Y 17:7675077-7675077 3
34 COSM45834 TP53 skin,NS,carcinoma,basal cell carcinoma c.409C>A p.L137M 17:7675203-7675203 3
35 COSM10654 TP53 skin,NS,carcinoma,basal cell carcinoma c.637C>T p.R213* 17:7674894-7674894 3
36 COSM10905 TP53 skin,NS,carcinoma,basal cell carcinoma c.451C>T p.P151S 17:7675161-7675161 3
37 COSM6932 TP53 skin,NS,carcinoma,basal cell carcinoma c.733G>A p.G245S 17:7674230-7674230 3
38 COSM10648 TP53 skin,NS,carcinoma,basal cell carcinoma c.524G>A p.R175H 17:7675088-7675088 3
39 COSM45424 TP53 skin,NS,carcinoma,basal cell carcinoma c.781A>T p.S261C 17:7674182-7674182 3
40 COSM10656 TP53 skin,NS,carcinoma,basal cell carcinoma c.742C>T p.R248W 17:7674221-7674221 3
41 COSM10659 TP53 skin,NS,carcinoma,basal cell carcinoma c.817C>T p.R273C 17:7673803-7673803 3
42 COSM10794 TP53 skin,NS,carcinoma,basal cell carcinoma c.796G>A p.G266R 17:7673824-7673824 3
43 COSM43582 TP53 skin,NS,carcinoma,basal cell carcinoma c.454C>T p.P152S 17:7675158-7675158 3
44 COSM10704 TP53 skin,NS,carcinoma,basal cell carcinoma c.844C>T p.R282W 17:7673776-7673776 3
45 COSM6549 TP53 skin,NS,carcinoma,basal cell carcinoma c.743G>T p.R248L 17:7674220-7674220 3
46 COSM10726 TP53 skin,NS,carcinoma,basal cell carcinoma c.856G>A p.E286K 17:7673764-7673764 3
47 COSM45304 TP53 skin,NS,carcinoma,basal cell carcinoma c.375+1G>A p.? 17:7675993-7675993 3
48 COSM10867 TP53 skin,NS,carcinoma,basal cell carcinoma c.797G>A p.G266E 17:7673823-7673823 3
49 COSM43714 TP53 skin,NS,carcinoma,basal cell carcinoma c.836G>A p.G279E 17:7673784-7673784 3
50 COSM44226 TP53 skin,NS,carcinoma,basal cell carcinoma c.380C>T p.S127F 17:7675232-7675232 3
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Expression for Clear Cell Basal Cell Carcinoma

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Search GEO for disease gene expression data for Clear Cell Basal Cell Carcinoma.
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Pathways for Clear Cell Basal Cell Carcinoma

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Pathways related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.82 KRT7 KRT19 KRT17
2
Keratinization 66
Show member pathways
 11.59 KRT7 KRT19 KRT17
3
Cytoskeleton remodeling Neurofilaments 22
Show member pathways
 10.83 KRT7 KRT19 KRT17
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GO Terms for Clear Cell Basal Cell Carcinoma

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Cellular components related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.96 KRT19 KRT17
2 intermediate filament GO:0005882 8.8 KRT7 KRT19 KRT17

Biological processes related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 9.16 PTCH1 KRT17
2 keratinization GO:0031424 9.13 KRT7 KRT19 KRT17
3 cornification GO:0070268 8.8 KRT7 KRT19 KRT17

Molecular functions related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 KRT19 KRT17
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Sources for Clear Cell Basal Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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