MCID: CLR015
MIFTS: 38

Clear Cell Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases
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Aliases & Classifications for Clear Cell Basal Cell Carcinoma

MalaCards integrated aliases for Clear Cell Basal Cell Carcinoma:

Name: Clear Cell Basal Cell Carcinoma 11 14
Skin Clear Cell Basal Cell Carcinoma 11 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4293
NCIt 49 C27536
UMLS 71 C1516599

Summaries for Clear Cell Basal Cell Carcinoma

MalaCards based summary: Clear Cell Basal Cell Carcinoma, also known as skin clear cell basal cell carcinoma, is related to epithelial-myoepithelial carcinoma and basal cell carcinoma. An important gene associated with Clear Cell Basal Cell Carcinoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Nervous system development and COPI-independent Golgi-to-ER retrograde traffic. Affiliated tissues include skin, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Clear Cell Basal Cell Carcinoma

Diseases related to Clear Cell Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 541)
# Related Disease Score Top Affiliating Genes
1 epithelial-myoepithelial carcinoma 30.3 KRT7 KRT5 KRT14
2 basal cell carcinoma 29.0 TP53 PTCH1 KRT7 KRT5 KRT20 KRT19
3 basal cell nevus syndrome 28.8 TP53 PTCH1 PAX7 PAX3 HRAS BCL2
4 basal cell carcinoma 1 10.6
5 inverted follicular keratosis 10.4 PHLDA1 KRT17
6 laryngeal adenoid cystic carcinoma 10.4 KRT7 KRT5
7 inverted transitional papilloma 10.4 KRT7 KRT5
8 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
9 ceruminoma 10.3 KRT7 KRT5
10 subareolar duct papillomatosis 10.3 KRT7 KRT5
11 bile duct signet ring cell carcinoma 10.3 KRT7 KRT20
12 prostatic urethral cancer 10.3 KRT7 KRT5
13 adamantinoma of long bones 10.3 KRT5 KRT19
14 nipple benign neoplasm 10.3 KRT7 KRT5
15 breast hemangiopericytoma 10.3 KRT7 KRT19
16 sarcomatoid basal cell carcinoma 10.3 KRT5 KRT20
17 rete testis neoplasm 10.3 KRT7 KRT5
18 rectum squamous cell carcinoma 10.3 KRT7 KRT5
19 rete testis adenocarcinoma 10.3 KRT7 KRT5
20 endometrial transitional cell carcinoma 10.3 KRT7 KRT20
21 leukoplakia of penis 10.3 KRT7 CEACAM5
22 nephrogenic adenoma of urinary bladder 10.3 KRT7 KRT20
23 breast mucoepidermoid carcinoma 10.3 KRT7 KRT5
24 papillary squamous carcinoma 10.3 KRT7 KRT5
25 ovarian mesodermal adenosarcoma 10.3 MYOG KRT7
26 atrophic vulva 10.3 KRT7 KRT20
27 eccrine papillary adenocarcinoma 10.3 PHLDA1 KRT5
28 bladder benign neoplasm 10.3 KRT7 KRT20
29 lacrimal gland mucoepidermoid carcinoma 10.3 KRT7 KRT20
30 cervical clear cell adenocarcinoma 10.3 KRT7 KRT19
31 gastric squamous cell carcinoma 10.3 KRT7 KRT5
32 malignant epithelial mesothelioma 10.3 KRT7 CEACAM5
33 parietal lobe neoplasm 10.3 MYOG KRT5
34 apocrine adenoma 10.3 KRT7 CEACAM5
35 vulval paget's disease 10.3 KRT7 CEACAM5
36 balloon cell malignant melanoma 10.3 KRT7 KRT5
37 neurofibroma of the esophagus 10.3 KRT19 CEACAM5
38 clear cell acanthoma 10.3 KRT5 CEACAM5
39 breast secretory carcinoma 10.3 KRT7 KRT5
40 breast adenoid cystic carcinoma 10.3 KRT7 KRT5
41 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
42 infiltrative basal cell carcinoma 10.3 PTCH1 KRT17
43 urethral diverticulum 10.3 KRT7 KRT20
44 eyelid carcinoma 10.3 KRT7 KRT20
45 eyelid benign neoplasm 10.3 KRT20 CHGA
46 meibomian cyst 10.3 KRT7 KRT20
47 follicular infundibulum tumor 10.3 PHLDA1 KRT20 KRT17
48 sinonasal undifferentiated carcinoma 10.3 KRT7 KRT5
49 morpheaform basal cell carcinoma 10.3 PHLDA1 KRT20 KRT17
50 basal cell carcinoma, infundibulocystic 10.3 PTCH1 PHLDA1

Graphical network of the top 20 diseases related to Clear Cell Basal Cell Carcinoma:



Diseases related to Clear Cell Basal Cell Carcinoma

Symptoms & Phenotypes for Clear Cell Basal Cell Carcinoma

MGI Mouse Phenotypes related to Clear Cell Basal Cell Carcinoma:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 BCL2 CDX2 CEACAM5 CHGA HRAS KRT14
2 homeostasis/metabolism MP:0005376 10.31 BCL2 CDX2 CEACAM5 CHGA HRAS KRT14
3 neoplasm MP:0002006 10.25 BCL2 CDX2 CEACAM5 HRAS KRT14 KRT19
4 endocrine/exocrine gland MP:0005379 10.2 BCL2 CDX2 CEACAM5 CHGA HRAS KRT14
5 digestive/alimentary MP:0005381 10.18 BCL2 CDX2 CEACAM5 HRAS KRT14 KRT17
6 muscle MP:0005369 10.16 BCL2 CEACAM5 CHGA HRAS MYOG PAX3
7 normal MP:0002873 10.14 CDX2 HRAS KRT19 MYOG PAX3 PAX7
8 no phenotypic analysis MP:0003012 10.13 CHGA HRAS KRT19 MYOG PAX3 PAX7
9 cellular MP:0005384 10.1 BCL2 CDX2 CEACAM5 KRT14 KRT17 KRT19
10 craniofacial MP:0005382 10.07 BCL2 HRAS KRT14 KRT17 KRT19 KRT5
11 pigmentation MP:0001186 10.03 BCL2 KRT14 KRT17 PAX3 PTCH1 TP53
12 embryo MP:0005380 10.03 BCL2 CDX2 KRT19 MYOG PAX3 PAX7
13 cardiovascular system MP:0005385 9.96 BCL2 CDX2 CEACAM5 CHGA HRAS KRT17
14 mortality/aging MP:0010768 9.8 BCL2 CDX2 CEACAM5 CHGA HRAS KRT14
15 respiratory system MP:0005388 9.76 HRAS KRT14 KRT19 MYOG PAX3 PAX7
16 integument MP:0010771 9.36 BCL2 HRAS KRT14 KRT17 KRT19 KRT5

Drugs & Therapeutics for Clear Cell Basal Cell Carcinoma

Search Clinical Trials, NIH Clinical Center for Clear Cell Basal Cell Carcinoma

Genetic Tests for Clear Cell Basal Cell Carcinoma

Anatomical Context for Clear Cell Basal Cell Carcinoma

Organs/tissues related to Clear Cell Basal Cell Carcinoma:

MalaCards : Skin

Publications for Clear Cell Basal Cell Carcinoma

Articles related to Clear Cell Basal Cell Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Solid Microcystic Adnexal Carcinoma on the Thigh: An Unusual Location. 62
31436574 2020
2
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. 62
31319387 2019
3
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review. 62
21048492 2011
4
Clear cell Basal cell carcinoma. 62
21559201 2011
5
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. 62
17414450 2007
6
Clear cell basal cell carcinoma with sialomucin deposition. 62
17191318 2006
7
Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis. 62
12641780 2003
8
Clear-cell basal cell carcinoma of the upper eyelid: a case report. 62
10454334 1999
9
Clear cell basal cell carcinoma: an unusual degenerative variant. 62
8227606 1993
10
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations. 62
1591688 1992
11
Clear cell basal cell carcinoma. 62
1706297 1990
12
Clear-cell, basal cell carcinoma: histopathological, histochemical, and electron microscopic findings. 62
3221000 1988
13
Signet-ring clear-cell basal cell carcinoma. 62
2456318 1988

Variations for Clear Cell Basal Cell Carcinoma

Cosmic variations for Clear Cell Basal Cell Carcinoma:

8 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510986 ZNF276 skin,NS,carcinoma,basal cell carcinoma c.*940C>T p.? 16:89739186-89739186 5
2 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 5
3 COSM87274302 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 5
4 COSM87270496 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 5
5 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 5
6 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 5
7 COSM87274307 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 5
8 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 5
9 COSM87273325 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 5
10 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 5
11 COSM87296537 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 5
12 COSM102023150 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7526C>T p.? 16:72958491-72958491 5
13 COSM102023155 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7920G>A p.? 16:72958885-72958885 5
14 COSM102019420 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8105C>T p.S2702F 16:72787429-72787429 5
15 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 5
16 COSM102023144 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.3083G>A p.G1028E 16:72796857-72796857 5
17 COSM102047764 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8308G>A p.D2770N 16:72787226-72787226 5
18 COSM87286441 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 5
19 COSM102036925 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7190C>T p.? 16:72958155-72958155 5
20 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 5
21 COSM102022243 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7097C>T p.? 16:72958062-72958062 5
22 COSM87274293 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 5
23 COSM104882801 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 5
24 COSM104236272 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 5
25 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 5
26 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
27 COSM101179498 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1913C>T p.S638F 16:2071897-2071897 5
28 COSM150324396 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
29 COSM101191558 TSC2 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.P241L 16:2058767-2058767 5
30 COSM147706701 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
31 COSM150353664 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 5
32 COSM151748023 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
33 COSM150576157 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
34 COSM149802478 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
35 COSM148980439 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 5
36 COSM90415129 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
37 COSM149800636 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 5
38 COSM148991757 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
39 COSM151753165 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
40 COSM151513825 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
41 COSM151371066 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
42 COSM148982237 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 5
43 COSM136628294 TSC2 skin,NS,carcinoma,basal cell carcinoma c.902C>T p.P301L 16:2058767-2058767 5
44 COSM110103971 TSC2 skin,NS,carcinoma,basal cell carcinoma c.568T>A p.C190S 16:2056674-2056674 5
45 COSM150583851 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5
46 COSM102616914 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 5
47 COSM136618116 TSC2 skin,NS,carcinoma,basal cell carcinoma c.712T>A p.C238S 16:2056674-2056674 5
48 COSM110102044 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1949C>T p.S650F 16:2071897-2071897 5
49 COSM150574866 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 5
50 COSM102629996 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 5

Expression for Clear Cell Basal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Basal Cell Carcinoma.

Pathways for Clear Cell Basal Cell Carcinoma

Pathways related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 MYOG KRT7 KRT5 KRT20 KRT19 KRT17
2
Show member pathways
12.14 KRT7 KRT5 KRT19 KRT17 KRT14
3 12.04 KRT7 KRT5 KRT20 KRT19 KRT17
4 11.65 TP53 HRAS BCL2
5
Show member pathways
11.64 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14
6 11.62 TP53 HRAS BCL2
7 11.56 PAX7 PAX3 MYOG
8 11.14 TP53 KRT5 KRT17 KRT14
9 10.1 TP53 BCL2

GO Terms for Clear Cell Basal Cell Carcinoma

Cellular components related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.56 KRT7 KRT5 KRT17 KRT14
2 intermediate filament GO:0005882 9.36 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Biological processes related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epithelial cell differentiation GO:0030855 9.76 KRT20 KRT19 KRT17 KRT14
2 animal organ morphogenesis GO:0009887 9.61 PTCH1 PAX3 HRAS CDX2 BCL2
3 B cell lineage commitment GO:0002326 9.56 TP53 BCL2
4 T cell lineage commitment GO:0002360 9.5 TP53 BCL2
5 intermediate filament organization GO:0045109 9.4 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Molecular functions related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.35 KRT20 KRT19 KRT17 KRT14
2 structural constituent of cytoskeleton GO:0005200 9.23 KRT5 KRT20 KRT19 KRT14

Sources for Clear Cell Basal Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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