MCID: CLR015
MIFTS: 39

Clear Cell Basal Cell Carcinoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Clear Cell Basal Cell Carcinoma

MalaCards integrated aliases for Clear Cell Basal Cell Carcinoma:

Name: Clear Cell Basal Cell Carcinoma 12 15
Skin Clear Cell Basal Cell Carcinoma 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4293
NCIt 50 C27536
UMLS 70 C1516599

Summaries for Clear Cell Basal Cell Carcinoma

MalaCards based summary : Clear Cell Basal Cell Carcinoma, also known as skin clear cell basal cell carcinoma, is related to basal cell carcinoma and apocrine adenocarcinoma. An important gene associated with Clear Cell Basal Cell Carcinoma is KRT17 (Keratin 17), and among its related pathways/superpathways are Developmental Biology and Relaxin signaling pathway. Affiliated tissues include skin, and related phenotypes are cellular and growth/size/body region

Related Diseases for Clear Cell Basal Cell Carcinoma

Diseases related to Clear Cell Basal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 450)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 28.5 TP53 PTCH1 PHLDA1 KRT7 KRT5 KRT20
2 apocrine adenocarcinoma 10.4 KRT7 KRT5
3 follicular infundibulum tumor 10.4 PHLDA1 KRT17
4 inverted follicular keratosis 10.4 PHLDA1 KRT17
5 ureter squamous cell carcinoma 10.4 KRT7 KRT5
6 inverted transitional papilloma 10.4 KRT7 KRT5
7 ceruminoma 10.4 KRT7 KRT5
8 subareolar duct papillomatosis 10.4 KRT7 KRT5
9 nipple benign neoplasm 10.4 KRT7 KRT5
10 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
11 proliferating trichilemmal cyst 10.4 KRT7 KRT19
12 lung clear cell carcinoma 10.4 KRT7 KRT5
13 gastric squamous cell carcinoma 10.4 KRT7 KRT5
14 bladder benign neoplasm 10.4 KRT7 KRT20
15 nephrogenic adenoma of urinary bladder 10.4 KRT7 KRT20
16 atrophic vulva 10.4 KRT7 KRT20
17 middle ear adenocarcinoma 10.4 KRT7 KRT5
18 breast mucinous carcinoma 10.4 KRT7 KRT5
19 infiltrative basal cell carcinoma 10.4 KRT20 KRT17
20 balloon cell malignant melanoma 10.3 KRT7 KRT5
21 leukoplakia of penis 10.3 KRT7 CEACAM5
22 thymus lipoma 10.3 KRT20 KRT19
23 immune system organ benign neoplasm 10.3 KRT20 KRT19
24 breast cystic hypersecretory carcinoma 10.3 KRT5 CEACAM5
25 eyelid carcinoma 10.3 KRT7 KRT20
26 gallbladder squamous cell carcinoma 10.3 KRT5 CEACAM5
27 vulva basal cell carcinoma 10.3 KRT5 CEACAM5
28 jejunal neoplasm 10.3 KRT7 KRT20
29 trachea carcinoma 10.3 KRT7 KRT5
30 pulmonary artery leiomyosarcoma 10.3 KRT7 KRT19
31 supine hypotensive syndrome 10.3 KRT7 KRT20
32 meibomian cyst 10.3 KRT7 KRT20
33 vulval paget's disease 10.3 KRT7 CEACAM5
34 acute orbital inflammation 10.3 KRT7 KRT20
35 colon leiomyosarcoma 10.3 KRT5 CEACAM5
36 ovarian germ cell teratoma 10.3 KRT7 KRT19
37 bile duct cystadenocarcinoma 10.3 KRT7 CEACAM5
38 basal cell carcinoma, infundibulocystic 10.3 PTCH1 PHLDA1
39 endobronchial lipoma 10.3 KRT7 KRT5
40 adenoid basal cell carcinoma 10.3 KRT7 CEACAM5
41 biliary papillomatosis 10.3 KRT7 CEACAM5
42 middle ear carcinoma 10.3 KRT7 KRT5
43 mucinous tubular and spindle renal cell carcinoma 10.3 KRT7 KRT19
44 esophageal neuroendocrine tumor 10.3 KRT5 CHGA
45 paratesticular lipoma 10.3 KRT19 CEACAM5
46 lipoma of spermatic cord 10.3 KRT19 CEACAM5
47 laryngeal small cell carcinoma 10.3 KRT5 CHGA
48 ovarian brenner tumor 10.3 KRT7 KRT20
49 liver sarcoma 10.3 KRT7 CEACAM5
50 gallbladder small cell carcinoma 10.3 KRT7 CHGA

Graphical network of the top 20 diseases related to Clear Cell Basal Cell Carcinoma:



Diseases related to Clear Cell Basal Cell Carcinoma

Symptoms & Phenotypes for Clear Cell Basal Cell Carcinoma

MGI Mouse Phenotypes related to Clear Cell Basal Cell Carcinoma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.19 CDX2 KRT14 KRT17 KRT19 KRT7 MYOG
2 growth/size/body region MP:0005378 10.14 CDX2 CHGA KRT14 KRT17 KRT19 KRT5
3 digestive/alimentary MP:0005381 10.11 CDX2 KRT14 KRT17 KRT19 KRT5 PAX3
4 craniofacial MP:0005382 10.08 KRT14 KRT17 KRT19 KRT5 PAX3 PAX7
5 mortality/aging MP:0010768 10.06 CDX2 CHGA KRT14 KRT17 KRT19 KRT5
6 endocrine/exocrine gland MP:0005379 10.03 CDX2 CHGA KRT14 KRT19 PAX3 PAX7
7 integument MP:0010771 10.02 KRT14 KRT17 KRT19 KRT5 MYOG PAX3
8 neoplasm MP:0002006 9.8 CDX2 KRT14 KRT19 PAX3 PAX7 PTCH1
9 no phenotypic analysis MP:0003012 9.76 CHGA KRT17 KRT19 MYOG PAX3 PAX7
10 pigmentation MP:0001186 9.35 KRT14 KRT17 PAX3 PTCH1 TP53
11 respiratory system MP:0005388 9.17 KRT14 KRT19 MYOG PAX3 PAX7 PTCH1

Drugs & Therapeutics for Clear Cell Basal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Basal Cell Carcinoma

Genetic Tests for Clear Cell Basal Cell Carcinoma

Anatomical Context for Clear Cell Basal Cell Carcinoma

MalaCards organs/tissues related to Clear Cell Basal Cell Carcinoma:

40
Skin

Publications for Clear Cell Basal Cell Carcinoma

Articles related to Clear Cell Basal Cell Carcinoma:

(show all 13)
# Title Authors PMID Year
1
Solid Microcystic Adnexal Carcinoma on the Thigh: An Unusual Location. 61
31436574 2020
2
PTCH1 Mutation in a Patient With Metastatic Undifferentiated Carcinoma With Clear Cell Change. 61
31319387 2019
3
Clear cell basal cell carcinoma with pulmonary metastasis: case report and literature review. 61
21048492 2011
4
Clear cell Basal cell carcinoma. 61
21559201 2011
5
Clear-cell basal cell carcinoma: differentiation from other clear-cell tumors. 61
17414450 2007
6
Clear cell basal cell carcinoma with sialomucin deposition. 61
17191318 2006
7
Basal cell carcinoma with tricholemmal (at the lower portion) differentiation within seborrheic keratosis. 61
12641780 2003
8
Clear-cell basal cell carcinoma of the upper eyelid: a case report. 61
10454334 1999
9
Clear cell basal cell carcinoma: an unusual degenerative variant. 61
8227606 1993
10
Balloon cell malignant melanoma of the skin. A clinicopathologic study of 34 cases with histochemical, immunohistochemical, and ultrastructural observations. 61
1591688 1992
11
Clear cell basal cell carcinoma. 61
1706297 1990
12
Clear-cell, basal cell carcinoma: histopathological, histochemical, and electron microscopic findings. 61
3221000 1988
13
Signet-ring clear-cell basal cell carcinoma. 61
2456318 1988

Variations for Clear Cell Basal Cell Carcinoma

Cosmic variations for Clear Cell Basal Cell Carcinoma:

9 (show top 50) (show all 3424)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510986 ZNF276 skin,NS,carcinoma,basal cell carcinoma c.*940C>T p.? 16:89739186-89739186 3
2 COSM149268805 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
3 COSM87274302 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
4 COSM87270496 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
5 COSM149259613 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.10847C>T p.S3616F 16:72787429-72787429 3
6 COSM149268792 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
7 COSM87274307 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1261G>A p.G421R 16:72958885-72958885 3
8 COSM149268800 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1655C>T p.S552F 16:72958491-72958491 3
9 COSM87273325 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
10 COSM149304906 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
11 COSM87296537 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
12 COSM102023150 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7526C>T p.? 16:72958491-72958491 3
13 COSM102023155 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7920G>A p.? 16:72958885-72958885 3
14 COSM102019420 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8105C>T p.S2702F 16:72787429-72787429 3
15 COSM149331772 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.11050G>A p.D3684N 16:72787226-72787226 3
16 COSM102023144 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.3083G>A p.G1028E 16:72796857-72796857 3
17 COSM102047764 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.8308G>A p.D2770N 16:72787226-72787226 3
18 COSM87286441 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.1991C>T p.S664F 16:72958155-72958155 3
19 COSM102036925 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7190C>T p.? 16:72958155-72958155 3
20 COSM149266372 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.2084C>T p.P695L 16:72958062-72958062 3
21 COSM102022243 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.-23-7097C>T p.? 16:72958062-72958062 3
22 COSM87274293 ZFHX3 skin,NS,carcinoma,basal cell carcinoma c.5825G>A p.G1942E 16:72796857-72796857 3
23 COSM104882801 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
24 COSM104236272 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
25 COSM101976974 XPO1 skin,NS,carcinoma,basal cell carcinoma c.782G>A p.R261Q 2:61496985-61496985 3
26 COSM87040659 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
27 COSM101179498 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1913C>T p.S638F 16:2071897-2071897 3
28 COSM150324396 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
29 COSM101191558 TSC2 skin,NS,carcinoma,basal cell carcinoma c.722C>T p.P241L 16:2058767-2058767 3
30 COSM147706701 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
31 COSM150353664 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
32 COSM151748023 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
33 COSM150576157 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
34 COSM149802478 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
35 COSM148980439 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
36 COSM90415129 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
37 COSM149800636 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
38 COSM148991757 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
39 COSM151753165 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
40 COSM151513825 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
41 COSM151371066 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
42 COSM148982237 TSC2 skin,NS,carcinoma,basal cell carcinoma c.679T>A p.C227S 16:2056674-2056674 3
43 COSM136628294 TSC2 skin,NS,carcinoma,basal cell carcinoma c.902C>T p.P301L 16:2058767-2058767 3
44 COSM110103971 TSC2 skin,NS,carcinoma,basal cell carcinoma c.568T>A p.C190S 16:2056674-2056674 3
45 COSM150583851 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3
46 COSM102616914 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
47 COSM136618116 TSC2 skin,NS,carcinoma,basal cell carcinoma c.712T>A p.C238S 16:2056674-2056674 3
48 COSM110102044 TSC2 skin,NS,carcinoma,basal cell carcinoma c.1949C>T p.S650F 16:2071897-2071897 3
49 COSM150574866 TSC2 skin,NS,carcinoma,basal cell carcinoma c.2060C>T p.S687F 16:2071897-2071897 3
50 COSM102629996 TSC2 skin,NS,carcinoma,basal cell carcinoma c.869C>T p.P290L 16:2058767-2058767 3

Expression for Clear Cell Basal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Basal Cell Carcinoma.

Pathways for Clear Cell Basal Cell Carcinoma

Pathways related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 MYOG KRT7 KRT5 KRT20 KRT19 KRT17
2
Show member pathways
12.33 KRT20 KRT19 KRT17 KRT14
3 12.21 KRT7 KRT5 KRT20 KRT19 KRT17
4
Show member pathways
11.89 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14
5 11.56 PAX7 PAX3 MYOG
6 11.54 KRT20 KRT19 KRT17 KRT14
7 11.37 TP53 KRT5 KRT17 KRT14
8
Show member pathways
11.05 KRT7 KRT5 KRT19 KRT17 KRT14

GO Terms for Clear Cell Basal Cell Carcinoma

Cellular components related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.33 KRT7 KRT5 KRT14
2 cell periphery GO:0071944 9.13 KRT19 KRT17 KRT14
3 intermediate filament GO:0005882 9.1 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Biological processes related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 TP53 PTCH1 PAX3 MYOG CDX2
2 apoptotic process GO:0006915 9.77 TP53 PHLDA1 PAX3 KRT20 CEACAM5
3 epidermis development GO:0008544 9.5 PTCH1 KRT5 KRT14
4 intermediate filament organization GO:0045109 9.43 KRT20 KRT17
5 muscle organ development GO:0007517 9.43 PAX7 PAX3 MYOG
6 keratinization GO:0031424 9.43 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14
7 hemidesmosome assembly GO:0031581 9.16 KRT5 KRT14
8 cornification GO:0070268 9.1 KRT7 KRT5 KRT20 KRT19 KRT17 KRT14

Molecular functions related to Clear Cell Basal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.55 TP53 PAX7 PAX3 MYOG CDX2
2 structural molecule activity GO:0005198 9.26 KRT20 KRT19 KRT17 KRT14
3 structural constituent of cytoskeleton GO:0005200 8.92 KRT5 KRT20 KRT19 KRT14

Sources for Clear Cell Basal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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