MCID: CLR005
MIFTS: 37

Clear Cell Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Chondrosarcoma

MalaCards integrated aliases for Clear Cell Chondrosarcoma:

Name: Clear Cell Chondrosarcoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5867
NCIt 51 C6475
UMLS 74 C1266167

Summaries for Clear Cell Chondrosarcoma

MalaCards based summary : Clear Cell Chondrosarcoma is related to chondrosarcoma and chondroblastoma, and has symptoms including pain An important gene associated with Clear Cell Chondrosarcoma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Spinal Cord Injury. Affiliated tissues include bone, brain and prostate, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Clear Cell Chondrosarcoma

Diseases related to Clear Cell Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 31.7 EXT2 PTHLH SOX9 SPARC
2 chondroblastoma 30.9 H3F3A H3F3B PTHLH SOX9
3 tooth ankylosis 10.4 PTHLH SPARC
4 intravascular papillary endothelial hyperplasia 10.4 SERPINA3 VIM
5 neurenteric cyst 10.4 KRT18 KRT8
6 peripheral osteosarcoma 10.3 POSTN PTHLH SPARC
7 chondromyxoid fibroma 10.3 PTHLH SOX9 VIM
8 osteochondroma 10.3 EXT2 PTHLH VIM
9 epithelioid leiomyosarcoma 10.3 SERPINA3 VIM
10 odontogenic myxoma 10.3 ACAN SERPINA3 VIM
11 endolymphatic sac tumor 10.3 KRT7 KRT8
12 enchondromatosis, multiple, ollier type 10.3 ACAN EXT2 PTHLH
13 bone giant cell sarcoma 10.3 H3F3A H3F3B TP53
14 malignant giant cell tumor 10.3 H3F3A H3F3B TP53
15 brain stem cancer 10.3 H3F3A H3F3B TP53
16 spinal cord astrocytoma 10.3 H3F3A H3F3B TP53
17 bone chondrosarcoma 10.3 ACAN RUNX2
18 nodular tenosynovitis 10.2 CD68 SERPINA3
19 odontoma 10.2 KRT18 KRT8 VIM
20 calcifying epithelial odontogenic tumor 10.2 KRT8 TP53
21 brain stem glioma 10.2 H3F3A H3F3B TP53
22 ameloblastoma 10.2 KRT18 KRT8 SERPINA3
23 cellular neurofibroma 10.2 PDGFRB TP53
24 supratentorial cancer 10.2 H3F3A H3F3B TP53
25 sclerosing hepatic carcinoma 10.2 PTH PTHLH
26 cerebrum cancer 10.2 H3F3A H3F3B TP53
27 parachordoma 10.2 KRT7 VIM
28 central nervous system cancer 10.2 H3F3A H3F3B TP53
29 sternum cancer 10.2 CD68 VIM
30 hidrocystoma 10.2 KRT7 KRT8
31 secretory meningioma 10.2 KRT7 VIM
32 adenoid squamous cell carcinoma 10.2 KRT7 KRT8 VIM
33 embryonal sarcoma 10.2 SERPINA3 TP53 VIM
34 invasive malignant thymoma 10.2 PTH PTHLH
35 metanephric adenoma 10.2 KRT18 KRT7 VIM
36 proliferating trichilemmal cyst 10.2 KRT18 KRT7 KRT8
37 cutaneous adenocystic carcinoma 10.2 KRT18 KRT7 KRT8
38 epithelioid sarcoma 10.2 KRT7 KRT8 VIM
39 granular cell tumor 10.2 CD68 SERPINA3 VIM
40 mucinous tubular and spindle renal cell carcinoma 10.2 KRT18 KRT7 KRT8
41 epithelioid trophoblastic tumor 10.2 KRT18 KRT7
42 lymphoepithelioma-like carcinoma 10.2 KRT18 KRT7 KRT8
43 malignant spiradenoma 10.2 KRT7 TP53
44 intraneural perineurioma 10.1 KRT18 KRT7 KRT8
45 nephrogenic adenofibroma 10.1 KRT18 KRT7 KRT8
46 vulvar intraepithelial neoplasia 10.1 KRT7 TP53
47 balloon cell malignant melanoma 10.1 CD68 KRT7
48 inflammatory mfh 10.1 CD68 SERPINA3
49 primary cutaneous amyloidosis 10.1 KRT18 KRT7 KRT8
50 nodular hidradenoma 10.1 KRT7 VIM

Graphical network of the top 20 diseases related to Clear Cell Chondrosarcoma:



Diseases related to Clear Cell Chondrosarcoma

Symptoms & Phenotypes for Clear Cell Chondrosarcoma

UMLS symptoms related to Clear Cell Chondrosarcoma:


pain

MGI Mouse Phenotypes related to Clear Cell Chondrosarcoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ANO1 KRT8 PDGFRB POSTN PTH PTHLH
2 growth/size/body region MP:0005378 10.21 ANO1 H3F3B KRT18 KRT8 PDGFRB POSTN
3 homeostasis/metabolism MP:0005376 10.15 ANO1 KRT7 KRT8 PDGFRB POSTN PTH
4 hematopoietic system MP:0005397 10.14 CD68 KRT8 PDGFRB POSTN PTH PTHLH
5 craniofacial MP:0005382 10.1 PDGFRB POSTN PTH PTHLH RUNX2 SOX9
6 embryo MP:0005380 10.06 EXT2 H3F3B KRT18 KRT8 PDGFRB SOX9
7 immune system MP:0005387 10.06 CD68 KRT8 PDGFRB POSTN PTH PTHLH
8 digestive/alimentary MP:0005381 10.02 ANO1 KRT8 PDGFRB PTHLH RUNX2 SOX9
9 mortality/aging MP:0010768 9.97 ANO1 EXT2 H3F3B KRT18 KRT8 PDGFRB
10 limbs/digits/tail MP:0005371 9.86 PDGFRB POSTN PTH PTHLH RUNX2 SOX9
11 reproductive system MP:0005389 9.61 H3F3B KRT8 PDGFRB POSTN PTHLH RUNX2
12 skeleton MP:0005390 9.36 ANO1 CD68 EXT2 PDGFRB POSTN PTH

Drugs & Therapeutics for Clear Cell Chondrosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vismodegib in Treating Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Clear Cell Chondrosarcoma

Genetic Tests for Clear Cell Chondrosarcoma

Anatomical Context for Clear Cell Chondrosarcoma

MalaCards organs/tissues related to Clear Cell Chondrosarcoma:

42
Bone, Brain, Prostate, Lung, Bone Marrow, Spinal Cord, Thymus

Publications for Clear Cell Chondrosarcoma

Articles related to Clear Cell Chondrosarcoma:

(show top 50) (show all 77)
# Title Authors Year
1
Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma. ( 30082492 )
2019
2
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. ( 29774790 )
2018
3
Clear cell chondrosarcoma of the larynx. ( 30181407 )
2018
4
Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report. ( 28925593 )
2018
5
Primary Clear Cell Chondrosarcoma of Thoracic Spine. ( 27577196 )
2017
6
Clear cell chondrosarcoma proximal femur with secondary aneurysmal component - A rarity. ( 28360507 )
2017
7
Clear cell chondrosarcoma calcaneum - a case report and review of literature. ( 25619455 )
2015
8
Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. ( 25198302 )
2015
9
An unusual case of clear cell chondrosarcoma with very late recurrence and lung metastases, 29 years after primary surgery. ( 25143849 )
2014
10
Multiple or metastatic clear cell chondrosarcoma: a case report. ( 25289140 )
2014
11
Clear cell chondrosarcoma: Cytologic findings in six cases. ( 24167115 )
2014
12
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. ( 24664395 )
2014
13
Primary laryngeal clear cell chondrosarcoma: report of a case and literature review. ( 24715432 )
2014
14
Clear-cell chondrosarcoma of the humerus. ( 27330631 )
2013
15
Epithelial and cartilaginous differentiation in clear cell chondrosarcoma. ( 22944296 )
2013
16
Primary clear cell chondrosarcoma of the spine: a case report of a rare entity and a review of the literature. ( 23091759 )
2012
17
Clear cell chondrosarcoma of the head and neck. ( 22520362 )
2012
18
Clear cell chondrosarcoma arising from the sternum: a rare tumor in an uncommon location. ( 22541211 )
2012
19
Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. ( 21242824 )
2011
20
Clear cell chondrosarcoma: an ultrastructural study. ( 19784747 )
2009
21
Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. ( 17522879 )
2008
22
Clear cell chondrosarcoma in the nasal septum. ( 18036435 )
2007
23
Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma. ( 16484006 )
2006
24
Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. ( 16703913 )
2006
25
Clear cell chondrosarcoma in association with niemann-pick disease. ( 18521415 )
2005
26
Clear cell chondrosarcoma of the proximal femur with intrapelvic extension. ( 15558292 )
2005
27
Skull metastasis from clear cell chondrosarcoma. ( 16041184 )
2005
28
Image features of two rare mediastinal tumors: schwannoma of intrathoracic phrenic nerve and clear cell chondrosarcoma of the rib. ( 16157055 )
2005
29
Cytogenetic findings in clear cell chondrosarcoma. ( 16157204 )
2005
30
An institutional review of clear cell chondrosarcoma. ( 16239809 )
2005
31
[Clear cell chondrosarcoma (CCCS) of the nasal septum]. ( 15088196 )
2004
32
Clear cell chondrosarcoma: radiographic, computed tomographic, and magnetic resonance findings in 34 patients with pathologic correlation. ( 14530882 )
2003
33
Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation. ( 11828329 )
2002
34
Clear cell chondrosarcoma mimicking chondroblastoma in a skeletally immature patient. ( 12073124 )
2002
35
Clear cell chondrosarcoma of the larynx: a case report of a rare histologic variant in an uncommon localization. ( 11859213 )
2002
36
Clear cell chondrosarcoma: unusual radiologic appearances with histologic correlation. ( 11870445 )
2002
37
Elevation of serum alkaline phosphatase in clear cell chondrosarcoma of bone. ( 11299821 )
2001
38
Overexpression of p53 and absent genetic mutation in clear cell chondrosarcoma. ( 11445851 )
2001
39
Clear cell chondrosarcoma of the larynx. ( 11458227 )
2001
40
Low incidence of genetic alterations of the p16CDKN2a in clear cell chondrosarcoma. ( 11562750 )
2001
41
Reactivation of tumor after 19 years? A case of local recurrence in clear cell chondrosarcoma. ( 10894383 )
2000
42
Dedifferentiated clear cell chondrosarcoma. ( 10935648 )
2000
43
Clear cell chondrosarcoma of bone. ( 18521273 )
1999
44
Clear cell chondrosarcoma: a pathological and immunohistochemical study. ( 10231420 )
1999
45
Clear cell chondrosarcoma of the pelvis in a skeletally immature patient. ( 10424338 )
1999
46
Musculoskeletal case of the day. Clear cell chondrosarcoma. ( 10470928 )
1999
47
Bifocal clear cell chondrosarcoma of femoral head. ( 9490982 )
1998
48
Chondrocytic cell differentiation in clear cell chondrosarcoma. ( 8958302 )
1996
49
Clear-cell chondrosarcoma with elevated alkaline phosphatase, mistaken for osteosarcoma on biopsy. ( 8958626 )
1996
50
Radiologic case study. Clear-cell chondrosarcoma. ( 7603927 )
1995

Variations for Clear Cell Chondrosarcoma

Expression for Clear Cell Chondrosarcoma

Search GEO for disease gene expression data for Clear Cell Chondrosarcoma.

Pathways for Clear Cell Chondrosarcoma

GO Terms for Clear Cell Chondrosarcoma

Cellular components related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 ACAN BGLAP H3F3A H3F3B POSTN PTH
2 extracellular exosome GO:0070062 9.91 ANO1 EXT2 H3F3A H3F3B KRT18 KRT7
3 collagen-containing extracellular matrix GO:0062023 9.67 ACAN POSTN SERPINA3 SPARC
4 keratin filament GO:0045095 9.58 KRT18 KRT7 KRT8
5 intermediate filament GO:0005882 9.26 KRT18 KRT7 KRT8 VIM
6 Barr body GO:0001740 9.16 H3F3A H3F3B
7 nuclear matrix GO:0016363 8.92 KRT8 SPARC TP53 VIM

Biological processes related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.95 KRT18 KRT7 KRT8 TP53 VIM
2 extracellular matrix organization GO:0030198 9.84 ACAN POSTN SOX9 SPARC
3 male gonad development GO:0008584 9.76 H3F3A H3F3B PDGFRB SOX9
4 wound healing GO:0042060 9.75 PDGFRB POSTN SPARC
5 osteoblast differentiation GO:0001649 9.73 BGLAP H3F3A H3F3B RUNX2
6 hepatocyte apoptotic process GO:0097284 9.57 KRT18 KRT8
7 response to gravity GO:0009629 9.56 BGLAP SPARC
8 pericentric heterochromatin assembly GO:0031508 9.52 H3F3A H3F3B
9 bone mineralization GO:0030282 9.51 BGLAP PTHLH
10 osteoblast development GO:0002076 9.5 BGLAP PTHLH RUNX2
11 cAMP metabolic process GO:0046058 9.49 PTH PTHLH
12 regulation of centromere complex assembly GO:0090230 9.48 H3F3A H3F3B
13 negative regulation of chondrocyte differentiation GO:0032331 9.43 PTH PTHLH SOX9
14 negative regulation of chromosome condensation GO:1902340 9.4 H3F3A H3F3B
15 telomeric heterochromatin assembly GO:0031509 9.37 H3F3A H3F3B
16 ossification GO:0001503 9.35 BGLAP EXT2 RUNX2 SOX9 SPARC
17 chondrocyte development GO:0002063 9.33 ACAN RUNX2 SOX9
18 skeletal system development GO:0001501 9.1 ACAN BGLAP PTH PTHLH RUNX2 SOX9

Molecular functions related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.65 EXT2 H3F3A H3F3B SOX9 TP53
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.5 H3F3A H3F3B TP53
3 peptide hormone receptor binding GO:0051428 9.16 PTH PTHLH
4 scaffold protein binding GO:0097110 9.13 KRT18 KRT8 VIM
5 structural molecule activity GO:0005198 8.8 BGLAP KRT18 VIM

Sources for Clear Cell Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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