MCID: CLR005
MIFTS: 37

Clear Cell Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Clear Cell Chondrosarcoma

MalaCards integrated aliases for Clear Cell Chondrosarcoma:

Name: Clear Cell Chondrosarcoma 12 15 71
Chondrosarcoma, Clear Cell 44

Classifications:



External Ids:

Disease Ontology 12 DOID:5867
MeSH 44 D000077207
NCIt 50 C6475
SNOMED-CT 67 128775007
UMLS 71 C1266167

Summaries for Clear Cell Chondrosarcoma

MalaCards based summary : Clear Cell Chondrosarcoma, also known as chondrosarcoma, clear cell, is related to chondrosarcoma and chondroblastic osteosarcoma, and has symptoms including pain An important gene associated with Clear Cell Chondrosarcoma is H3-3B (H3.3 Histone B), and among its related pathways/superpathways are Gene Expression and Developmental Biology. Affiliated tissues include bone and bone marrow.

Wikipedia : 74 A bone sarcoma is a primary malignant bone tumour, a type of sarcoma that starts in the bones. This is... more...

Related Diseases for Clear Cell Chondrosarcoma

Diseases related to Clear Cell Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.3 SPARC SERPINA3 RUNX2 PTHLH IDH2
2 chondroblastic osteosarcoma 29.7 SERPINA3 IDH2 H3-3B H3-3A
3 chondroblastoma 29.4 SERPINA3 PTHLH H3C6 H3C4 H3C3 H3-3B
4 bone sarcoma 29.2 SERPINA3 RUNX2 IDH2 H2AC18
5 osteogenic sarcoma 10.4
6 rare tumor 10.4
7 bone giant cell sarcoma 10.3 H3-3B H3-3A
8 malignant giant cell tumor 10.3 H3-3B H3-3A
9 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
10 spinal cord astrocytoma 10.3 H3-3B H3-3A
11 childhood pilocytic astrocytoma 10.2 H3-3B H3-3A
12 juvenile pilocytic astrocytoma 10.2 H3-3B H3-3A
13 colon leiomyoma 10.2 H3-3B H3-3A
14 spinal cord glioma 10.2 H3-3B H3-3A
15 aneurysmal bone cysts 10.2
16 osteoblastoma 10.2
17 primary bone cancer 10.2
18 spinal cancer 10.2 H3-3B H3-3A
19 fibrosarcomatous osteosarcoma 10.2 SPARC SERPINA3
20 papillary cystadenocarcinoma 10.2 SPARC SERPINA3
21 conventional central osteosarcoma 10.1 SPARC SERPINA3
22 von hippel-lindau syndrome 10.1
23 chondroma 10.1
24 mesenchymal chondrosarcoma 10.1
25 47,xyy 10.1
26 avascular necrosis 10.1
27 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3B H3-3A H2AC18
28 bone giant cell tumor 10.1 SERPINA3 H3-3B H3-3A
29 infratentorial cancer 10.1 H3-3B H3-3A H2AC18
30 benign giant cell tumor 10.1 SERPINA3 H3-3B H3-3A
31 d-2-hydroxyglutaric aciduria 2 10.1 IDH2 H2AC18
32 histiocytosis-lymphadenopathy plus syndrome 10.0 SERPINA3 H2AC18
33 adult brain stem glioma 10.0 IDH2 H3-3B H3-3A
34 adult oligodendroglioma 10.0 IDH2 H3-3B H3-3A
35 childhood oligodendroglioma 10.0 IDH2 H3-3B H3-3A
36 adult astrocytic tumour 10.0 IDH2 H3-3B H3-3A
37 progressive relapsing multiple sclerosis 10.0 SERPINA3 H2AC18
38 epithelioid leiomyosarcoma 10.0 SERPINA3 PTHLH
39 myositis 10.0
40 muscle hypertrophy 10.0
41 bone chondrosarcoma 10.0
42 plica syndrome 10.0
43 leukemia 10.0
44 niemann-pick disease 10.0
45 synovitis 10.0
46 neurilemmoma 10.0
47 mammary paget's disease 10.0
48 clear cell sarcoma 10.0
49 myxoid chondrosarcoma 10.0
50 myositis ossificans 10.0

Graphical network of the top 20 diseases related to Clear Cell Chondrosarcoma:



Diseases related to Clear Cell Chondrosarcoma

Symptoms & Phenotypes for Clear Cell Chondrosarcoma

UMLS symptoms related to Clear Cell Chondrosarcoma:


pain

Drugs & Therapeutics for Clear Cell Chondrosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of GDC-0449 in Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Clear Cell Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, clear cell

Genetic Tests for Clear Cell Chondrosarcoma

Anatomical Context for Clear Cell Chondrosarcoma

MalaCards organs/tissues related to Clear Cell Chondrosarcoma:

40
Bone, Bone Marrow

Publications for Clear Cell Chondrosarcoma

Articles related to Clear Cell Chondrosarcoma:

(show top 50) (show all 138)
# Title Authors PMID Year
1
Functional optimisation in chondrosarcoma of the subglottis: a novel surgical approach. 61
33563684 2021
2
CORR Insights®: What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma? 61
32433106 2020
3
What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma? 61
32297725 2020
4
Clear cell chondrosarcoma of proximal femur: a rare entity with diagnostic dilemma. 61
33122229 2020
5
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2020
6
Clear cell chondrosarcoma in Von Hippel-Lindau disease. 61
31673890 2020
7
Clear cell chondrosarcoma of the talus in Von Hippel-Lindau disease: a rare tumor in an unusual location and uncommon co-presentation. 61
32211108 2020
8
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
9
Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature. 61
31788417 2019
10
Risk Factors for Incidence and Prognosis in Chondrosarcoma Patients with Pulmonary Metastasis at Initial Diagnosis. 61
31885034 2019
11
Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma. 61
30082492 2019
12
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. 61
29774790 2018
13
Clear cell chondrosarcoma of the larynx. 61
30181407 2018
14
Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report. 61
28925593 2018
15
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint. 61
30202513 2018
16
Reconstruction with iliac pedestal cup and proximal femur tumor prosthesis after wide resection of chondrosarcoma - 10-year follow-up results. 61
29234663 2017
17
Chondroblastoma: An Update. 61
28557595 2017
18
Primary Clear Cell Chondrosarcoma of Thoracic Spine. 61
27577196 2017
19
Clear cell chondrosarcoma proximal femur with secondary aneurysmal component - A rarity. 61
28360507 2017
20
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. 61
26844533 2016
21
Chondroblastoma: An Unusual Cause Of Shoulder Pain In Adolescence. 61
30151442 2016
22
Clear cell chondrosarcoma calcaneum - a case report and review of literature. 61
25619455 2015
23
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
24
Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. 61
25244180 2015
25
Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. 61
25198302 2015
26
Clear cell chondrosarcoma: Cytologic findings in six cases. 61
24167115 2014
27
[A case of clear cell chondrosarcoma in nasal septum]. 61
24820502 2014
28
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. 61
24664395 2014
29
An unusual case of clear cell chondrosarcoma with very late recurrence and lung metastases, 29 years after primary surgery. 61
25143849 2014
30
[Clear cell chondrosarcoma of cricoid cartilage: report of a case]. 61
24713250 2014
31
Primary laryngeal clear cell chondrosarcoma: report of a case and literature review. 61
24715432 2014
32
Multiple or metastatic clear cell chondrosarcoma: a case report. 61
25289140 2014
33
Advanced chondrosarcomas: role of chemotherapy and survival. 61
24099780 2013
34
The imaging of cartilaginous bone tumours. II. Chondrosarcoma. 61
23053201 2013
35
Epithelial and cartilaginous differentiation in clear cell chondrosarcoma. 61
22944296 2013
36
Clear-cell chondrosarcoma of the humerus. 61
27330631 2013
37
Clear cell chondrosarcoma arising from the sternum: a rare tumor in an uncommon location. 61
22541211 2012
38
Clear cell chondrosarcoma of the head and neck. 61
22520362 2012
39
Primary clear cell chondrosarcoma of the spine: a case report of a rare entity and a review of the literature. 61
23091759 2012
40
Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report. 61
22289277 2012
41
[Clear cell chondrosarcoma without osteoclast-like giant cells: report of a case]. 61
21914353 2011
42
Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. 61
21242824 2011
43
Clear cell chondrosarcoma: an ultrastructural study. 61
19784747 2009
44
The clinical approach towards chondrosarcoma. 61
18378543 2008
45
Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. 61
17522879 2008
46
Conventional intramedullary chondrosarcoma with subarticular involvement. 61
18164401 2008
47
Clear cell chondrosarcoma in the nasal septum. 61
18036435 2007
48
[Clear cell chondrosarcoma: report of a case]. 61
17845769 2007
49
[Pathohistology of femoral head necrosis]. 61
17450348 2007
50
Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. 61
17076530 2006

Variations for Clear Cell Chondrosarcoma

Cosmic variations for Clear Cell Chondrosarcoma:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM106056882 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
2 COSM111763021 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
3 COSM144313682 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
4 COSM105659131 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
5 COSM93187807 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
6 COSM143375075 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
7 COSM105624912 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
8 COSM122766413 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
9 COSM145021980 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
10 COSM93215390 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
11 COSM143182864 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
12 COSM144334467 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
13 COSM143972614 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
14 COSM87902864 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
15 COSM112257156 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
16 COSM142564162 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
17 COSM144655779 TP53 soft tissue,upper leg,sarcoma,NS c.524A>G p.H175R 17:7674890-7674890 3
18 COSM142840367 TP53 soft tissue,upper leg,sarcoma,NS c.641A>G p.H214R 17:7674890-7674890 3
19 COSM122737959 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
20 COSM144111084 TP53 soft tissue,upper leg,sarcoma,NS c.22C>T p.Q8* 17:7675113-7675113 3
21 COSM121881087 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
22 COSM142860117 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
23 COSM144089819 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
24 COSM144682712 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
25 COSM143159971 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
26 COSM122275322 TP53 soft tissue,upper leg,sarcoma,NS c.245A>G p.H82R 17:7674890-7674890 3
27 COSM144041526 TP53 soft tissue,upper leg,sarcoma,NS c.466C>T p.Q156* 17:7675113-7675113 3
28 COSM142592590 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
29 COSM106084061 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
30 COSM112284809 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
31 COSM143401670 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
32 COSM122302302 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
33 COSM143947426 TP53 soft tissue,upper leg,sarcoma,NS c.164A>G p.H55R 17:7674890-7674890 3
34 COSM144017515 TP53 soft tissue,upper leg,sarcoma,NS c.608A>G p.H203R 17:7674890-7674890 3
35 COSM121910283 TP53 soft tissue,upper leg,sarcoma,NS c.103C>T p.Q35* 17:7675113-7675113 3
36 COSM111790424 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
37 COSM145045823 TP53 soft tissue,upper leg,sarcoma,NS c.382C>T p.Q128* 17:7675113-7675113 3
38 COSM87935416 TP53 soft tissue,upper leg,sarcoma,NS c.499C>T p.Q167* 17:7675113-7675113 3
39 COSM92479334 SH2B3 soft tissue,upper leg,sarcoma,NS c.232G>A p.E78K 12:111418377-111418377 3
40 COSM135372634 NUP93 soft tissue,upper leg,sarcoma,NS c.116C>T p.A39V 16:56748363-56748363 3
41 COSM88525472 NUP93 soft tissue,upper leg,sarcoma,NS c.116C>T p.A39V 16:56748363-56748363 3
42 COSM95516578 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
43 COSM95520543 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
44 COSM95523461 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
45 COSM95526780 H3-3A soft tissue,bone,sarcoma,NS c.103G>T p.G35W 1:226064454-226064454 3
46 COSM87494413 GNAQ soft tissue,bone,sarcoma,NS c.442C>T p.R148* 9:77815650-77815650 3
47 COSM98577250 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3
48 COSM87618826 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3
49 COSM147901996 ANKRD11 soft tissue,upper leg,sarcoma,NS c.2882G>T p.R961L 16:89283660-89283660 3

Expression for Clear Cell Chondrosarcoma

Search GEO for disease gene expression data for Clear Cell Chondrosarcoma.

Pathways for Clear Cell Chondrosarcoma

Pathways related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 RUNX2 H3C6 H3C4 H3C3 H3-3B H3-3A
2
Show member pathways
13.25 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
3
Show member pathways
13.17 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
4
Show member pathways
13.1 SPARC SERPINA3 H3C6 H3C4 H3C3 H3-3B
5
Show member pathways
12.95 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
6
Show member pathways
12.85 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
7
Show member pathways
12.81 H3C6 H3C4 H3C3 H3-3B H3-3A
8
Show member pathways
12.7 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
9
Show member pathways
12.5 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
10 12.22 H3C6 H3C4 H3C3 H3-3B H3-3A
11
Show member pathways
12.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
12 11.96 H3C6 H3C4 H3C3 H3-3B H3-3A
13
Show member pathways
11.83 H3C6 H3C4 H3C3 H3-3B H3-3A
14
Show member pathways
11.81 H3C6 H3C4 H3C3 H3-3B H3-3A
15 11.38 RUNX2 H3C6 H3C4 H3C3 H3-3B H3-3A
16 11.31 H3C6 H3C4 H3C3 H3-3B H3-3A
17 11.12 H3C6 H3C4 H3C3
18 11.09 H3-3B H3-3A

GO Terms for Clear Cell Chondrosarcoma

Cellular components related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.11 SPARC SERPINA3 RUNX2 RAB6C PTHLH H3C6
2 extracellular region GO:0005576 9.92 SPARC SERPINA3 PTHLH H3C6 H3C4 H3C3
3 extracellular exosome GO:0070062 9.86 SERPINA3 IDH2 H3C6 H3C4 H3C3 H3-3B
4 protein-containing complex GO:0032991 9.83 H3C6 H3C4 H3C3 H3-3B H3-3A
5 chromosome GO:0005694 9.63 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
6 Barr body GO:0001740 9.4 H3-3B H3-3A
7 nuclear chromosome GO:0000228 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
8 nucleosome GO:0000786 9.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18

Biological processes related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.85 H3C6 H3C4 H3C3 H3-3B H3-3A
2 blood coagulation GO:0007596 9.83 H3C6 H3C4 H3C3 H3-3B H3-3A
3 nucleosome assembly GO:0006334 9.77 H3C6 H3C4 H3C3 H3-3B H3-3A
4 osteoblast differentiation GO:0001649 9.73 RUNX2 H3-3B H3-3A
5 regulation of gene silencing by miRNA GO:0060964 9.72 H3C6 H3C4 H3C3 H3-3B H3-3A
6 DNA replication-dependent nucleosome assembly GO:0006335 9.7 H3C6 H3C4 H3C3
7 interleukin-7-mediated signaling pathway GO:0038111 9.65 H3C6 H3C4 H3C3
8 regulation of megakaryocyte differentiation GO:0045652 9.65 H3C6 H3C4 H3C3 H3-3B H3-3A
9 nucleus organization GO:0006997 9.59 H3-3B H3-3A
10 DNA replication-independent nucleosome assembly GO:0006336 9.58 H3-3B H3-3A
11 muscle cell differentiation GO:0042692 9.58 H3-3B H3-3A
12 regulation of gene silencing GO:0060968 9.58 H3C6 H3C4 H3C3
13 osteoblast development GO:0002076 9.57 RUNX2 PTHLH
14 pericentric heterochromatin assembly GO:0031508 9.55 H3-3B H3-3A
15 negative regulation of gene expression, epigenetic GO:0045814 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.54 H3-3B H3-3A
17 negative regulation of chromosome condensation GO:1902340 9.51 H3-3B H3-3A
18 telomeric heterochromatin assembly GO:0031509 9.49 H3-3B H3-3A
19 chromatin silencing at rDNA GO:0000183 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
20 telomere organization GO:0032200 9.02 H3C6 H3C4 H3C3 H3-3B H3-3A

Molecular functions related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 SERPINA3 RUNX2 H3C6 H3C4 H3C3 H3-3B
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.16 H3-3B H3-3A
3 protein heterodimerization activity GO:0046982 9.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18

Sources for Clear Cell Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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