MCID: CLR005
MIFTS: 34

Clear Cell Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Clear Cell Chondrosarcoma

MalaCards integrated aliases for Clear Cell Chondrosarcoma:

Name: Clear Cell Chondrosarcoma 12 15 71
Chondrosarcoma, Clear Cell 43

Classifications:



External Ids:

Disease Ontology 12 DOID:5867
MeSH 43 D000077207
NCIt 49 C6475
SNOMED-CT 67 128775007
UMLS 71 C1266167

Summaries for Clear Cell Chondrosarcoma

MalaCards based summary : Clear Cell Chondrosarcoma, also known as chondrosarcoma, clear cell, is related to chondroblastic osteosarcoma and chondrosarcoma, and has symptoms including pain An important gene associated with Clear Cell Chondrosarcoma is H3-3B (H3.3 Histone B), and among its related pathways/superpathways are Gene Expression and Developmental Biology. The drugs Doxorubicin and Daunorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and bone marrow.

Related Diseases for Clear Cell Chondrosarcoma

Diseases related to Clear Cell Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 chondroblastic osteosarcoma 30.1 SERPINA3 IDH1
2 chondrosarcoma 29.8 SPARC SERPINA3 RUNX2 PTHLH IDH1
3 chondroblastoma 29.2 SERPINA3 PTHLH H3C6 H3C3 H3-3B H3-3A
4 bone sarcoma 28.9 SERPINA3 RUNX2 IDH1 H2AC18
5 osteogenic sarcoma 10.4
6 rare tumor 10.4
7 bone giant cell sarcoma 10.4 H3-3B H3-3A
8 malignant giant cell tumor 10.4 H3-3B H3-3A
9 kunjin encephalitis 10.4 H3-3B H3-3A
10 pneumoconiosis due to talc 10.4 H3-3B H3-3A
11 mental retardation, autosomal dominant 56 10.3 H3-3B H3-3A
12 congenital disorder of glycosylation, type il 10.3 H3-3B H3-3A
13 amelogenesis imperfecta, type if 10.3 H3-3B H3-3A
14 fibrosarcomatous osteosarcoma 10.3 SPARC SERPINA3
15 amelogenesis imperfecta, type ia 10.3 H3-3B H3-3A
16 papillary cystadenocarcinoma 10.3 SPARC SERPINA3
17 aneurysmal bone cysts 10.3
18 neurodegeneration with brain iron accumulation 6 10.2 H3-3B H3-3A
19 osteoblastoma 10.2
20 primary bone cancer 10.2
21 bone giant cell tumor 10.2 SERPINA3 H3-3B H3-3A
22 actinomycosis 10.1 H3-3B H3-3A H2AC18
23 hypotrichosis 2 10.1 H3-3B H3-3A H2AC18
24 mulibrey nanism 10.1 H3-3B H3-3A H2AC18
25 cerebellar astrocytoma 10.1 SERPINA3 IDH1
26 hypotrichosis 1 10.1 H3-3B H3-3A H2AC18
27 von hippel-lindau syndrome 10.1
28 chondroma 10.1
29 mesenchymal chondrosarcoma 10.1
30 connective tissue benign neoplasm 10.1 SERPINA3 H3-3A H2AC18
31 alpha-thalassemia 10.1 H3-3B H3-3A H2AC18
32 mast cell neoplasm 10.0 SERPINA3 H2AC18
33 adult brain stem glioma 10.0 IDH1 H3-3B H3-3A
34 spinal cord astrocytoma 10.0 IDH1 H3-3B H3-3A
35 epithelioid leiomyosarcoma 10.0 SERPINA3 PTHLH
36 histiocytosis-lymphadenopathy plus syndrome 10.0 SERPINA3 H2AC18
37 pleomorphic xanthoastrocytoma 10.0 SERPINA3 IDH1 H3-3A
38 myositis 10.0
39 muscle hypertrophy 10.0
40 bone chondrosarcoma 10.0
41 plica syndrome 10.0
42 leukemia 10.0
43 niemann-pick disease 10.0
44 synovitis 10.0
45 neurilemmoma 10.0
46 mammary paget's disease 10.0
47 clear cell sarcoma 10.0
48 myxoid chondrosarcoma 10.0
49 myositis ossificans 10.0
50 47,xyy 10.0

Graphical network of the top 20 diseases related to Clear Cell Chondrosarcoma:



Diseases related to Clear Cell Chondrosarcoma

Symptoms & Phenotypes for Clear Cell Chondrosarcoma

UMLS symptoms related to Clear Cell Chondrosarcoma:


pain

Drugs & Therapeutics for Clear Cell Chondrosarcoma

Drugs for Clear Cell Chondrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
6 Alkylating Agents Phase 2, Phase 3
7
Liposomal doxorubicin Phase 2, Phase 3 31703
8 Anti-Bacterial Agents Phase 2, Phase 3
9
Isophosphamide mustard Phase 2, Phase 3 0
10 Antibiotics, Antitubercular Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754) Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
2 A Phase 2 Study of GDC-0449 in Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Clear Cell Chondrosarcoma

Cochrane evidence based reviews: chondrosarcoma, clear cell

Genetic Tests for Clear Cell Chondrosarcoma

Anatomical Context for Clear Cell Chondrosarcoma

MalaCards organs/tissues related to Clear Cell Chondrosarcoma:

40
Bone, Lung, Bone Marrow

Publications for Clear Cell Chondrosarcoma

Articles related to Clear Cell Chondrosarcoma:

(show top 50) (show all 137)
# Title Authors PMID Year
1
CORR Insights®: What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma? 61
32433106 2020
2
What Factors Are Associated with Treatment Outcomes of Japanese Patients with Clear Cell Chondrosarcoma? 61
32297725 2020
3
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2020
4
Clear cell chondrosarcoma in Von Hippel-Lindau disease. 61
31673890 2020
5
Clear cell chondrosarcoma of the talus in Von Hippel-Lindau disease: a rare tumor in an unusual location and uncommon co-presentation. 61
32211108 2020
6
Risk Factors for Incidence and Prognosis in Chondrosarcoma Patients with Pulmonary Metastasis at Initial Diagnosis. 61
31885034 2019
7
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
8
Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature. 61
31788417 2019
9
Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma. 61
30082492 2019
10
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. 61
29774790 2018
11
Clear cell chondrosarcoma of the larynx. 61
30181407 2018
12
Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report. 61
28925593 2018
13
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint. 61
30202513 2018
14
Reconstruction with iliac pedestal cup and proximal femur tumor prosthesis after wide resection of chondrosarcoma - 10-year follow-up results. 61
29234663 2017
15
Chondroblastoma: An Update. 61
28557595 2017
16
Primary Clear Cell Chondrosarcoma of Thoracic Spine. 61
27577196 2017
17
Clear cell chondrosarcoma proximal femur with secondary aneurysmal component - A rarity. 61
28360507 2017
18
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. 61
26844533 2016
19
Chondroblastoma: An Unusual Cause Of Shoulder Pain In Adolescence. 61
30151442 2016
20
Clear cell chondrosarcoma calcaneum - a case report and review of literature. 61
25619455 2015
21
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
22
Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. 61
25198302 2015
23
Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. 61
25244180 2015
24
Clear cell chondrosarcoma: Cytologic findings in six cases. 61
24167115 2014
25
[A case of clear cell chondrosarcoma in nasal septum]. 61
24820502 2014
26
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. 61
24664395 2014
27
Multiple or metastatic clear cell chondrosarcoma: a case report. 61
25289140 2014
28
[Clear cell chondrosarcoma of cricoid cartilage: report of a case]. 61
24713250 2014
29
Primary laryngeal clear cell chondrosarcoma: report of a case and literature review. 61
24715432 2014
30
An unusual case of clear cell chondrosarcoma with very late recurrence and lung metastases, 29 years after primary surgery. 61
25143849 2014
31
Advanced chondrosarcomas: role of chemotherapy and survival. 61
24099780 2013
32
The imaging of cartilaginous bone tumours. II. Chondrosarcoma. 61
23053201 2013
33
Epithelial and cartilaginous differentiation in clear cell chondrosarcoma. 61
22944296 2013
34
Clear-cell chondrosarcoma of the humerus. 61
27330631 2013
35
Clear cell chondrosarcoma arising from the sternum: a rare tumor in an uncommon location. 61
22541211 2012
36
Clear cell chondrosarcoma of the head and neck. 61
22520362 2012
37
Primary clear cell chondrosarcoma of the spine: a case report of a rare entity and a review of the literature. 61
23091759 2012
38
Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report. 61
22289277 2012
39
[Clear cell chondrosarcoma without osteoclast-like giant cells: report of a case]. 61
21914353 2011
40
Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. 61
21242824 2011
41
Clear cell chondrosarcoma: an ultrastructural study. 61
19784747 2009
42
The clinical approach towards chondrosarcoma. 61
18378543 2008
43
Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. 61
17522879 2008
44
Conventional intramedullary chondrosarcoma with subarticular involvement. 61
18164401 2008
45
Clear cell chondrosarcoma in the nasal septum. 61
18036435 2007
46
[Clear cell chondrosarcoma: report of a case]. 61
17845769 2007
47
[Pathohistology of femoral head necrosis]. 61
17450348 2007
48
Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. 61
17076530 2006
49
Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. 61
16703913 2006
50
Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma. 61
16484006 2006

Variations for Clear Cell Chondrosarcoma

Expression for Clear Cell Chondrosarcoma

Search GEO for disease gene expression data for Clear Cell Chondrosarcoma.

Pathways for Clear Cell Chondrosarcoma

Pathways related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.54 RUNX2 H3C6 H3C4 H3C3 H3-3B H3-3A
2
Show member pathways
13.25 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
3
Show member pathways
13.17 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
4
Show member pathways
13.1 SPARC SERPINA3 H3C6 H3C4 H3C3 H3-3B
5
Show member pathways
12.95 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
6
Show member pathways
12.85 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
7
Show member pathways
12.81 H3C6 H3C4 H3C3 H3-3B H3-3A
8
Show member pathways
12.7 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
9
Show member pathways
12.5 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
10 12.21 H3C6 H3C4 H3C3 H3-3B H3-3A
11
Show member pathways
12.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
12 11.96 H3C6 H3C4 H3C3 H3-3B H3-3A
13
Show member pathways
11.83 H3C6 H3C4 H3C3 H3-3B H3-3A
14
Show member pathways
11.81 H3C6 H3C4 H3C3 H3-3B H3-3A
15 11.38 RUNX2 H3C6 H3C4 H3C3 H3-3B H3-3A
16 11.31 H3C6 H3C4 H3C3 H3-3B H3-3A
17 11.12 H3C6 H3C4 H3C3
18 11.09 H3-3B H3-3A

GO Terms for Clear Cell Chondrosarcoma

Cellular components related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 10.14 SPARC SERPINA3 RUNX2 RAB6C PTHLH H3C6
2 extracellular exosome GO:0070062 9.97 SERPINA3 IDH1 H3C6 H3C4 H3C3 H3-3B
3 extracellular region GO:0005576 9.97 SPARC SERPINA3 PTHLH IDH1 H3C6 H3C4
4 protein-containing complex GO:0032991 9.85 H3C6 H3C4 H3C3 H3-3B H3-3A
5 chromosome GO:0005694 9.73 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18
6 nuclear chromosome GO:0000228 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
7 Barr body GO:0001740 9.43 H3-3B H3-3A
8 nuclear nucleosome GO:0000788 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
9 nucleosome GO:0000786 9.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18

Biological processes related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 chromatin organization GO:0006325 9.87 H3C6 H3C4 H3C3 H2AC18
2 cellular protein metabolic process GO:0044267 9.85 H3C6 H3C4 H3C3 H3-3B H3-3A
3 blood coagulation GO:0007596 9.83 H3C6 H3C4 H3C3 H3-3B H3-3A
4 nucleosome assembly GO:0006334 9.77 H3C6 H3C4 H3C3 H3-3B H3-3A
5 osteoblast differentiation GO:0001649 9.73 RUNX2 H3-3B H3-3A
6 regulation of gene silencing by miRNA GO:0060964 9.72 H3C6 H3C4 H3C3 H3-3B H3-3A
7 DNA replication-dependent nucleosome assembly GO:0006335 9.7 H3C6 H3C4 H3C3
8 interleukin-7-mediated signaling pathway GO:0038111 9.65 H3C6 H3C4 H3C3
9 regulation of megakaryocyte differentiation GO:0045652 9.65 H3C6 H3C4 H3C3 H3-3B H3-3A
10 nucleus organization GO:0006997 9.6 H3-3B H3-3A
11 DNA replication-independent nucleosome assembly GO:0006336 9.59 H3-3B H3-3A
12 osteoblast development GO:0002076 9.58 RUNX2 PTHLH
13 muscle cell differentiation GO:0042692 9.58 H3-3B H3-3A
14 regulation of gene silencing GO:0060968 9.58 H3C6 H3C4 H3C3
15 pericentric heterochromatin assembly GO:0031508 9.55 H3-3B H3-3A
16 negative regulation of gene expression, epigenetic GO:0045814 9.55 H3C6 H3C4 H3C3 H3-3B H3-3A
17 regulation of centromere complex assembly GO:0090230 9.54 H3-3B H3-3A
18 negative regulation of chromosome condensation GO:1902340 9.51 H3-3B H3-3A
19 telomeric heterochromatin assembly GO:0031509 9.49 H3-3B H3-3A
20 chromatin silencing at rDNA GO:0000183 9.35 H3C6 H3C4 H3C3 H3-3B H3-3A
21 telomere organization GO:0032200 9.02 H3C6 H3C4 H3C3 H3-3B H3-3A

Molecular functions related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.56 SERPINA3 RUNX2 H3C6 H3C4 H3C3 H3-3B
2 cadherin binding GO:0045296 9.46 IDH1 H3C6 H3C4 H3C3
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.26 H3-3B H3-3A
4 protein heterodimerization activity GO:0046982 9.1 H3C6 H3C4 H3C3 H3-3B H3-3A H2AC18

Sources for Clear Cell Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....