MCID: CLR005
MIFTS: 31

Clear Cell Chondrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Chondrosarcoma

MalaCards integrated aliases for Clear Cell Chondrosarcoma:

Name: Clear Cell Chondrosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5867
NCIt 49 C6475
UMLS 71 C1266167

Summaries for Clear Cell Chondrosarcoma

MalaCards based summary : Clear Cell Chondrosarcoma is related to enchondroma and chondroblastoma, and has symptoms including pain An important gene associated with Clear Cell Chondrosarcoma is H3-3B (H3.3 Histone B), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. Affiliated tissues include bone, breast and brain, and related phenotypes are Decreased p24 protein expression and limbs/digits/tail

Related Diseases for Clear Cell Chondrosarcoma

Diseases related to Clear Cell Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 enchondroma 30.3 IDH2 IDH1
2 chondroblastoma 30.1 SOX9 SERPINA3 PTHLH H3-3B H3-3A
3 mesenchymal chondrosarcoma 29.7 SPARC SOX9
4 chondroblastic osteosarcoma 29.3 SERPINA3 IDH2 IDH1 H3-3B H3-3A
5 chondrosarcoma 28.9 SPARC SOX9 SERPINA3 RUNX2 PTHLH IDH2
6 diffuse intrinsic pontine glioma 10.4 H3-3B H3-3A
7 osteogenic sarcoma 10.4
8 bone giant cell sarcoma 10.4 H3-3B H3-3A
9 malignant giant cell tumor 10.4 H3-3B H3-3A
10 telangiectatic osteogenic sarcoma 10.4 H3-3B H3-3A
11 rare tumor 10.4
12 colon leiomyoma 10.4 H3-3B H3-3A
13 fibrosarcomatous osteosarcoma 10.3 SPARC SERPINA3
14 brain stem cancer 10.3 H3-3B H3-3A
15 papillary cystadenocarcinoma 10.3 SPARC SERPINA3
16 aneurysmal bone cysts 10.3
17 osseous heteroplasia, progressive 10.3 SPARC RUNX2
18 epithelioid leiomyosarcoma 10.2 SERPINA3 PTHLH
19 osteoblastoma 10.2
20 primary bone cancer 10.2
21 bone giant cell tumor 10.2 SERPINA3 H3-3B H3-3A
22 giant cell tumor 10.2 SERPINA3 H3-3B H3-3A
23 breast duct papilloma 10.2 IDH2 IDH1
24 cytogenetically normal acute myeloid leukemia 10.2 IDH2 IDH1
25 intracranial chondrosarcoma 10.2 IDH2 IDH1
26 central nervous system rhabdomyosarcoma 10.2 IDH2 IDH1
27 periosteal chondrosarcoma 10.2 IDH2 IDH1
28 pancreatic endocrine carcinoma 10.2 SERPINA3 PTHLH
29 periosteal osteogenic sarcoma 10.1 RUNX2 EXT2
30 breast hemangioma 10.1 IDH2 IDH1
31 spinal cord oligodendroglioma 10.1 IDH2 IDH1
32 spinal cord astrocytoma 10.1 IDH1 H3-3B H3-3A
33 pilocytic astrocytoma of cerebellum 10.1 IDH1 H3-3B H3-3A
34 interval angle-closure glaucoma 10.1 IDH2 IDH1
35 childhood pilocytic astrocytoma 10.1 IDH1 H3-3B H3-3A
36 gemistocytic astrocytoma 10.1 IDH2 IDH1
37 spinal cord glioma 10.1 IDH1 H3-3B H3-3A
38 malignant ependymoma 10.1 IDH1 H3-3B H3-3A
39 undifferentiated pleomorphic sarcoma 10.1 IDH2 IDH1
40 juvenile pilocytic astrocytoma 10.1 IDH1 H3-3B H3-3A
41 intraductal breast neoplasm 10.1 IDH2 IDH1
42 pilomyxoid astrocytoma 10.1 IDH1 H3-3B H3-3A
43 chondroma 10.1
44 mixed glioma 10.1 IDH2 IDH1
45 infratentorial cancer 10.1 IDH1 H3-3B H3-3A
46 phosphorus metabolism disease 10.1 RUNX2 PTHLH
47 pigmented villonodular synovitis 10.1 SERPINA3 PTHLH
48 aortic valve disease 2 10.1 SPARC SERPINA3 RUNX2
49 intraductal papilloma 10.1 IDH2 IDH1
50 fibrous dysplasia 10.1 SPARC RUNX2 PTHLH

Graphical network of the top 20 diseases related to Clear Cell Chondrosarcoma:



Diseases related to Clear Cell Chondrosarcoma

Symptoms & Phenotypes for Clear Cell Chondrosarcoma

UMLS symptoms related to Clear Cell Chondrosarcoma:


pain

GenomeRNAi Phenotypes related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased p24 protein expression GR00163-A-1 8.8 H3-3A IDH1 RAB6C

MGI Mouse Phenotypes related to Clear Cell Chondrosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.35 IDH2 PTHLH RUNX2 SOX9 SPARC
2 skeleton MP:0005390 9.17 EXT2 IDH1 IDH2 PTHLH RUNX2 SOX9

Drugs & Therapeutics for Clear Cell Chondrosarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of GDC-0449 in Patients With Advanced Chondrosarcomas Active, not recruiting NCT01267955 Phase 2 Vismodegib

Search NIH Clinical Center for Clear Cell Chondrosarcoma

Genetic Tests for Clear Cell Chondrosarcoma

Anatomical Context for Clear Cell Chondrosarcoma

MalaCards organs/tissues related to Clear Cell Chondrosarcoma:

40
Bone, Breast, Brain, Spinal Cord, Cerebellum, Lung, Bone Marrow

Publications for Clear Cell Chondrosarcoma

Articles related to Clear Cell Chondrosarcoma:

(show top 50) (show all 133)
# Title Authors PMID Year
1
Risk Factors for Incidence and Prognosis in Chondrosarcoma Patients with Pulmonary Metastasis at Initial Diagnosis. 61
31885034 2019
2
Conventional chondrosarcoma with focal clear cell change: a clinicopathological and molecular analysis. 61
31297850 2019
3
Clear cell chondrosarcoma is an underestimated tumor: Report of 7 cases and meta-analysis of the literature. 61
31788417 2019
4
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2019
5
Clear cell chondrosarcoma in Von Hippel-Lindau disease. 61
31673890 2019
6
Outcome of First-Line Systemic Treatment for Unresectable Conventional, Dedifferentiated, Mesenchymal, and Clear Cell Chondrosarcoma. 61
30082492 2019
7
Clear Cell Chondrosarcoma With Chondroblastoma-Like Features: A Case for Team Diagnosis. 61
29774790 2018
8
Clear cell chondrosarcoma of the larynx. 61
30181407 2018
9
Fine needle aspiration biopsy diagnosis of primary clear cell chondrosarcoma: A case report. 61
28925593 2018
10
Periostin expression in neoplastic and non-neoplastic diseases of bone and joint. 61
30202513 2018
11
Reconstruction with iliac pedestal cup and proximal femur tumor prosthesis after wide resection of chondrosarcoma - 10-year follow-up results. 61
29234663 2017
12
Chondroblastoma: An Update. 61
28557595 2017
13
Primary Clear Cell Chondrosarcoma of Thoracic Spine. 61
27577196 2017
14
Clear cell chondrosarcoma proximal femur with secondary aneurysmal component - A rarity. 61
28360507 2017
15
The H3F3 K36M mutant antibody is a sensitive and specific marker for the diagnosis of chondroblastoma. 61
26844533 2016
16
Chondroblastoma: An Unusual Cause Of Shoulder Pain In Adolescence. 61
30151442 2016
17
Clear cell chondrosarcoma calcaneum - a case report and review of literature. 61
25619455 2015
18
ERG expression in chondrogenic bone and soft tissue tumours. 61
25378537 2015
19
Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. 61
25244180 2015
20
Delayed diagnosis of clear cell chondrosarcoma after total hip replacement. A case report of a rare entity encountered in common surgery. 61
25198302 2015
21
Clear cell chondrosarcoma: Cytologic findings in six cases. 61
24167115 2014
22
[A case of clear cell chondrosarcoma in nasal septum]. 61
24820502 2014
23
Clear cell chondrosarcoma with secondary aneurysmal bone cyst changes. 61
24664395 2014
24
[Clear cell chondrosarcoma of cricoid cartilage: report of a case]. 61
24713250 2014
25
Multiple or metastatic clear cell chondrosarcoma: a case report. 61
25289140 2014
26
Primary laryngeal clear cell chondrosarcoma: report of a case and literature review. 61
24715432 2014
27
An unusual case of clear cell chondrosarcoma with very late recurrence and lung metastases, 29 years after primary surgery. 61
25143849 2014
28
Advanced chondrosarcomas: role of chemotherapy and survival. 61
24099780 2013
29
The imaging of cartilaginous bone tumours. II. Chondrosarcoma. 61
23053201 2013
30
Epithelial and cartilaginous differentiation in clear cell chondrosarcoma. 61
22944296 2013
31
Clear-cell chondrosarcoma of the humerus. 61
27330631 2013
32
Clear cell chondrosarcoma arising from the sternum: a rare tumor in an uncommon location. 61
22541211 2012
33
Clear cell chondrosarcoma of the head and neck. 61
22520362 2012
34
Response to sunitinib in combination with proton beam radiation in a patient with chondrosarcoma: a case report. 61
22289277 2012
35
Primary clear cell chondrosarcoma of the spine: a case report of a rare entity and a review of the literature. 61
23091759 2012
36
[Clear cell chondrosarcoma without osteoclast-like giant cells: report of a case]. 61
21914353 2011
37
Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. 61
21242824 2011
38
Clear cell chondrosarcoma: an ultrastructural study. 61
19784747 2009
39
The clinical approach towards chondrosarcoma. 61
18378543 2008
40
Clear cell chondrosarcoma of bone: long time follow-up of 18 cases. 61
17522879 2008
41
Conventional intramedullary chondrosarcoma with subarticular involvement. 61
18164401 2008
42
Clear cell chondrosarcoma in the nasal septum. 61
18036435 2007
43
[Clear cell chondrosarcoma: report of a case]. 61
17845769 2007
44
[Pathohistology of femoral head necrosis]. 61
17450348 2007
45
Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases. 61
17076530 2006
46
Primary clear-cell chondrosarcoma of the cervical spine. Case illustration. 61
16703913 2006
47
Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma. 61
16484006 2006
48
[Cartilage tumors. Classification, conditions for biopsy and histologic characteristics]. 61
16322881 2005
49
An institutional review of clear cell chondrosarcoma. 61
16239809 2005
50
Cytogenetic findings in clear cell chondrosarcoma. 61
16157204 2005

Variations for Clear Cell Chondrosarcoma

Expression for Clear Cell Chondrosarcoma

Search GEO for disease gene expression data for Clear Cell Chondrosarcoma.

Pathways for Clear Cell Chondrosarcoma

Pathways related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 RUNX2 H3-3B H3-3A
2 10.91 RUNX2 PTHLH
3 10.78 H3-3B H3-3A
4 10.61 SOX9 RUNX2 PTHLH
5
Show member pathways
10.07 IDH2 IDH1

GO Terms for Clear Cell Chondrosarcoma

Cellular components related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.74 SOX9 RUNX2 PTHLH
2 nucleosome assembly GO:0006334 9.67 SOX9 H3-3B H3-3A
3 osteoblast differentiation GO:0001649 9.65 RUNX2 H3-3B H3-3A
4 male gonad development GO:0008584 9.63 SOX9 H3-3B H3-3A
5 chromatin silencing at rDNA GO:0000183 9.62 H3-3B H3-3A
6 cellular response to BMP stimulus GO:0071773 9.62 SOX9 RUNX2
7 oogenesis GO:0048477 9.61 H3-3B H3-3A
8 tricarboxylic acid cycle GO:0006099 9.61 IDH2 IDH1
9 nucleus organization GO:0006997 9.6 H3-3B H3-3A
10 telomere organization GO:0032200 9.59 H3-3B H3-3A
11 DNA replication-independent nucleosome assembly GO:0006336 9.58 H3-3B H3-3A
12 positive regulation of chondrocyte differentiation GO:0032332 9.58 SOX9 RUNX2
13 negative regulation of chondrocyte differentiation GO:0032331 9.56 SOX9 PTHLH
14 chondrocyte development GO:0002063 9.55 SOX9 RUNX2
15 osteoblast development GO:0002076 9.54 RUNX2 PTHLH
16 muscle cell differentiation GO:0042692 9.52 H3-3B H3-3A
17 2-oxoglutarate metabolic process GO:0006103 9.51 IDH2 IDH1
18 NADP metabolic process GO:0006739 9.43 IDH2 IDH1
19 isocitrate metabolic process GO:0006102 9.4 IDH2 IDH1
20 pericentric heterochromatin assembly GO:0031508 9.37 H3-3B H3-3A
21 regulation of centromere complex assembly GO:0090230 9.32 H3-3B H3-3A
22 negative regulation of chromosome condensation GO:1902340 9.26 H3-3B H3-3A
23 telomeric heterochromatin assembly GO:0031509 9.16 H3-3B H3-3A
24 glyoxylate cycle GO:0006097 8.96 IDH2 IDH1
25 ossification GO:0001503 8.92 SPARC SOX9 RUNX2 EXT2

Molecular functions related to Clear Cell Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.37 IDH2 IDH1
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 9.32 H3-3B H3-3A
3 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH2 IDH1
4 bHLH transcription factor binding GO:0043425 9.16 SOX9 RUNX2
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
6 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Clear Cell Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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