MCID: CLR011
MIFTS: 32

Clear Cell Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Ependymoma

MalaCards integrated aliases for Clear Cell Ependymoma:

Name: Clear Cell Ependymoma 12 56 15
Cellular Ependymoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5507
UMLS 74 C1384403

Summaries for Clear Cell Ependymoma

MalaCards based summary : Clear Cell Ependymoma, also known as cellular ependymoma, is related to ependymoma and benign ependymoma. An important gene associated with Clear Cell Ependymoma is VIM (Vimentin), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Carboplatin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and cerebellum.

Related Diseases for Clear Cell Ependymoma

Diseases related to Clear Cell Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.2 ENO2 GFAP MUC1 SYP VIM
2 benign ependymoma 30.7 ENO2 GFAP SYP
3 oligodendroglioma 30.0 ENO2 GFAP SYP
4 hemangioblastoma 29.2 ENO2 GFAP MUC1 SYP
5 liver angiosarcoma 10.2 ENO2 VIM
6 fibrolamellar carcinoma 10.2 SYP VIM
7 congenital epulis 10.2 ENO2 VIM
8 chondrosarcoma, extraskeletal myxoid 10.2 ENO2 SYP
9 paraganglioma 10.2 ENO2 SYP
10 malignant pheochromocytoma 10.2 ENO2 SYP
11 peripheral nervous system neoplasm 10.2 ENO2 SYP
12 mixed cell type cancer 10.2 ENO2 SYP
13 neuroendocrine tumor 10.2 ENO2 SYP
14 adrenal rest tumor 10.2 ENO2 SYP
15 sweat gland cancer 10.2 ENO2 SYP
16 cranial nerve malignant neoplasm 10.2 ENO2 SYP
17 optic nerve neoplasm 10.2 ENO2 SYP
18 lung benign neoplasm 10.2 ENO2 SYP
19 olfactory neuroblastoma 10.2 ENO2 SYP
20 adrenal carcinoma 10.2 ENO2 SYP
21 large cell carcinoma 10.2 ENO2 SYP
22 pineal parenchymal tumor of intermediate differentiation 10.2 ENO2 SYP
23 bednar tumor 10.2 ENO2 VIM
24 horseshoe kidney 10.2 ENO2 SYP
25 leiomyosarcoma 10.2 ENO2 VIM
26 primary hepatic neuroendocrine carcinoma 10.2 SYP VIM
27 epulis 10.2 ENO2 VIM
28 myoepithelioma 10.2 GFAP VIM
29 epithelioid leiomyosarcoma 10.2 ENO2 VIM
30 hemangioma 10.2 ENO2 SYP
31 carotid body cancer 10.1 ENO2 SYP
32 malignant sertoli cell tumor 10.1 ENO2 SYP
33 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
34 small cell carcinoma 10.1 ENO2 SYP
35 auditory system cancer 10.1 ENO2 SYP
36 pancreatic somatostatinoma 10.1 ENO2 SYP
37 cutaneous ganglioneuroma 10.1 ENO2 SYP
38 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
39 small cell carcinoma of the bladder 10.1 ENO2 SYP
40 sensory organ benign neoplasm 10.1 ENO2 SYP
41 orbital cancer 10.1 ENO2 SYP
42 brain injury 10.1 ENO2 GFAP
43 traumatic brain injury 10.1 ENO2 GFAP
44 supratentorial cancer 10.1 GFAP SYP
45 ileum cancer 10.1 ENO2 GFAP
46 atypical teratoid rhabdoid tumor 10.1 GFAP SYP
47 status epilepticus 10.1 ENO2 GFAP
48 giant cell glioblastoma 10.1 GFAP SYP
49 cerebellopontine angle tumor 10.1 GFAP SYP
50 cerebrum cancer 10.1 GFAP SYP

Graphical network of the top 20 diseases related to Clear Cell Ependymoma:



Diseases related to Clear Cell Ependymoma

Symptoms & Phenotypes for Clear Cell Ependymoma

Drugs & Therapeutics for Clear Cell Ependymoma

Drugs for Clear Cell Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
7 Antimitotic Agents Phase 3
8 Antineoplastic Agents, Alkylating Phase 3
9 Immunosuppressive Agents Phase 3
10 Keratolytic Agents Phase 3
11 Dermatologic Agents Phase 3
12 Podophyllotoxin Phase 3 518-28-5
13 Alkylating Agents Phase 3
14 Immunologic Factors Phase 3,Phase 1
15 Antirheumatic Agents Phase 3
16 Etoposide phosphate Phase 3
17 Antineoplastic Agents, Phytogenic Phase 3
18 Topoisomerase Inhibitors Phase 3
19 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome
2 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1

Search NIH Clinical Center for Clear Cell Ependymoma

Genetic Tests for Clear Cell Ependymoma

Anatomical Context for Clear Cell Ependymoma

MalaCards organs/tissues related to Clear Cell Ependymoma:

42
Brain, Pineal, Cerebellum, Bone, Lung, Ovary, Cervix

Publications for Clear Cell Ependymoma

Articles related to Clear Cell Ependymoma:

(show all 31)
# Title Authors Year
1
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
2
Clear cell ependymoma with late leptomeningeal and supratentorial metastases. ( 26431995 )
2016
3
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
4
Clear cell ependymoma in a dog. ( 23273584 )
2013
5
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. ( 22009009 )
2012
6
Clear cell ependymoma with trisomy 19 developing bone metastases. ( 22207400 )
2012
7
A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions. ( 21643803 )
2011
8
Intraparenchymal clear cell ependymoma. ( 21713151 )
2011
9
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. ( 22102956 )
2011
10
Clear cell ependymoma occurring in the cauda equina. ( 20856665 )
2010
11
Malignant transformation of supratentorial clear cell ependymoma. ( 18647267 )
2009
12
Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. ( 20035139 )
2009
13
Clear cell ependymoma of the temporal lobe in a child: a case report. ( 18097199 )
2008
14
Clear-cell ependymoma: a report of intracortical tumor with significant desmoplasia. ( 18194140 )
2008
15
Clear cell ependymoma: a mimicker of oligodendroglioma--report of three cases. ( 18248576 )
2008
16
Imaging features of clear-cell ependymoma of the spinal cord. ( 17279401 )
2007
17
Clear-cell ependymoma of the cerebellum: a case report. ( 17614003 )
2007
18
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. ( 17626628 )
2007
19
Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. ( 17923743 )
2007
20
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. ( 16277226 )
2005
21
Clear cell ependymoma of the fourth ventricle. ( 15641594 )
2004
22
Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review. ( 12713564 )
2003
23
Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. ( 12870256 )
2003
24
Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. ( 14601094 )
2003
25
Intramedullary clear cell ependymoma in the cervical spinal cord: case report. ( 11126915 )
2000
26
Mucin-secreting cellular ependymoma: a light and electron microscopy study. ( 10582269 )
1999
27
Cerebellar clear cell ependymoma mimicking hemangioblastoma: its clinical and pathological features. ( 10086492 )
1999
28
[Clear cell ependymoma--a case report]. ( 9621365 )
1998
29
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. ( 9236838 )
1997
30
Malignant primitive neuroepithelial tumour of soft tissues mimicking a cellular ependymoma. ( 1495851 )
1992
31
Clear cell ependymoma. A histological variant with diagnostic implications. ( 2477945 )
1989

Variations for Clear Cell Ependymoma

Expression for Clear Cell Ependymoma

Search GEO for disease gene expression data for Clear Cell Ependymoma.

Pathways for Clear Cell Ependymoma

Pathways related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 ENO2 GFAP SYP
2
Show member pathways
11.19 GFAP VIM
3 10.7 GFAP SYP VIM

GO Terms for Clear Cell Ependymoma

Biological processes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 GFAP VIM

Sources for Clear Cell Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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