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MCID: CLR011
MIFTS: 32

Clear Cell Ependymoma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Clear Cell Ependymoma

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MalaCards integrated aliases for Clear Cell Ependymoma:

Name: Clear Cell Ependymoma 12 56 15
Cellular Ependymoma 74

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:5507
UMLS 74 C1384403
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Summaries for Clear Cell Ependymoma

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MalaCards based summary : Clear Cell Ependymoma, also known as cellular ependymoma, is related to ependymoma and oligodendroglioma. An important gene associated with Clear Cell Ependymoma is VIM (Vimentin), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. The drugs Vincristine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cerebellum and bone.

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Related Diseases for Clear Cell Ependymoma

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Diseases related to Clear Cell Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.2 ENO2 GFAP MUC1 SYP VIM
2 oligodendroglioma 30.0 ENO2 GFAP SYP
3 hemangioblastoma 29.2 ENO2 GFAP MUC1 SYP
4 liver angiosarcoma 10.2 ENO2 VIM
5 fibrolamellar carcinoma 10.2 SYP VIM
6 congenital epulis 10.2 ENO2 VIM
7 chondrosarcoma, extraskeletal myxoid 10.2 ENO2 SYP
8 paraganglioma 10.2 ENO2 SYP
9 malignant pheochromocytoma 10.2 ENO2 SYP
10 peripheral nervous system neoplasm 10.2 ENO2 SYP
11 mixed cell type cancer 10.2 ENO2 SYP
12 neuroendocrine tumor 10.2 ENO2 SYP
13 adrenal rest tumor 10.2 ENO2 SYP
14 sweat gland cancer 10.2 ENO2 SYP
15 cranial nerve malignant neoplasm 10.2 ENO2 SYP
16 optic nerve neoplasm 10.2 ENO2 SYP
17 lung benign neoplasm 10.2 ENO2 SYP
18 olfactory neuroblastoma 10.2 ENO2 SYP
19 adrenal carcinoma 10.2 ENO2 SYP
20 large cell carcinoma 10.2 ENO2 SYP
21 pineal parenchymal tumor of intermediate differentiation 10.2 ENO2 SYP
22 bednar tumor 10.2 ENO2 VIM
23 horseshoe kidney 10.2 ENO2 SYP
24 leiomyosarcoma 10.2 ENO2 VIM
25 primary hepatic neuroendocrine carcinoma 10.2 SYP VIM
26 epulis 10.2 ENO2 VIM
27 myoepithelioma 10.2 GFAP VIM
28 epithelioid leiomyosarcoma 10.2 ENO2 VIM
29 hemangioma 10.2 ENO2 SYP
30 carotid body cancer 10.1 ENO2 SYP
31 malignant sertoli cell tumor 10.1 ENO2 SYP
32 urinary bladder small cell neuroendocrine carcinoma 10.1 ENO2 SYP
33 small cell carcinoma 10.1 ENO2 SYP
34 auditory system cancer 10.1 ENO2 SYP
35 pancreatic somatostatinoma 10.1 ENO2 SYP
36 cutaneous ganglioneuroma 10.1 ENO2 SYP
37 extrahepatic bile duct adenocarcinoma 10.1 ENO2 SYP
38 small cell carcinoma of the bladder 10.1 ENO2 SYP
39 sensory organ benign neoplasm 10.1 ENO2 SYP
40 orbital cancer 10.1 ENO2 SYP
41 brain injury 10.1 ENO2 GFAP
42 traumatic brain injury 10.1 ENO2 GFAP
43 supratentorial cancer 10.1 GFAP SYP
44 ileum cancer 10.1 ENO2 GFAP
45 atypical teratoid rhabdoid tumor 10.1 GFAP SYP
46 status epilepticus 10.1 ENO2 GFAP
47 giant cell glioblastoma 10.1 GFAP SYP
48 cerebellopontine angle tumor 10.1 GFAP SYP
49 cerebrum cancer 10.1 GFAP SYP
50 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP

Graphical network of the top 20 diseases related to Clear Cell Ependymoma:



Diseases related to Clear Cell Ependymoma
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Symptoms & Phenotypes for Clear Cell Ependymoma

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Drugs & Therapeutics for Clear Cell Ependymoma

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Drugs for Clear Cell Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
4
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
5
Cisplatin Approved Phase 3 15663-27-1 441203 84093 2767
6
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
7 Immunologic Factors Phase 3,Phase 1
8 Antimitotic Agents Phase 3
9 Dermatologic Agents Phase 3
10 Antirheumatic Agents Phase 3
11 Etoposide phosphate Phase 3
12 Podophyllotoxin Phase 3 518-28-5
13 Topoisomerase Inhibitors Phase 3
14 Antineoplastic Agents, Phytogenic Phase 3
15 Immunosuppressive Agents Phase 3
16 Antineoplastic Agents, Alkylating Phase 3
17 Alkylating Agents Phase 3
18 Keratolytic Agents Phase 3
19 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome
2 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1

Search NIH Clinical Center for Clear Cell Ependymoma

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Genetic Tests for Clear Cell Ependymoma

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Anatomical Context for Clear Cell Ependymoma

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MalaCards organs/tissues related to Clear Cell Ependymoma:

42
Spinal Cord, Cerebellum, Bone, Temporal Lobe, Medulla Oblongata
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Publications for Clear Cell Ependymoma

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Articles related to Clear Cell Ependymoma:

(show all 28)
# Title Authors Year
1
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
2
Clear cell ependymoma with late leptomeningeal and supratentorial metastases. ( 26431995 )
2015
3
Clear cell ependymoma in a dog. ( 23273584 )
2013
4
Clear cell ependymoma with trisomy 19 developing bone metastases. ( 22207400 )
2012
5
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. ( 22009009 )
2012
6
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. ( 22102956 )
2011
7
A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions. ( 21643803 )
2011
8
Intraparenchymal clear cell ependymoma. ( 21713151 )
2011
9
Clear cell ependymoma occurring in the cauda equina. ( 20856665 )
2010
10
Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. ( 20035139 )
2009
11
Malignant transformation of supratentorial clear cell ependymoma. ( 18647267 )
2009
12
Clear cell ependymoma of the temporal lobe in a child: a case report. ( 18097199 )
2008
13
Clear cell ependymoma: a mimicker of oligodendroglioma--report of three cases. ( 18248576 )
2008
14
Clear-cell ependymoma: a report of intracortical tumor with significant desmoplasia. ( 18194140 )
2008
15
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. ( 17626628 )
2007
16
Imaging features of clear-cell ependymoma of the spinal cord. ( 17279401 )
2007
17
Clear-cell ependymoma of the cerebellum: a case report. ( 17614003 )
2007
18
Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. ( 17923743 )
2007
19
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. ( 16277226 )
2005
20
Clear cell ependymoma of the fourth ventricle. ( 15641594 )
2004
21
Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review. ( 12713564 )
2003
22
Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. ( 14601094 )
2003
23
Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. ( 12870256 )
2003
24
Intramedullary clear cell ependymoma in the cervical spinal cord: case report. ( 11126915 )
2000
25
Cerebellar clear cell ependymoma mimicking hemangioblastoma: its clinical and pathological features. ( 10086492 )
1999
26
[Clear cell ependymoma--a case report]. ( 9621365 )
1998
27
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. ( 9236838 )
1997
28
Clear cell ependymoma. A histological variant with diagnostic implications. ( 2477945 )
1989
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Variations for Clear Cell Ependymoma

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Expression for Clear Cell Ependymoma

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Search GEO for disease gene expression data for Clear Cell Ependymoma.
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Pathways for Clear Cell Ependymoma

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Pathways related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
11.67 ENO2 GFAP SYP
2
Cytoskeleton remodeling Neurofilaments 23
Show member pathways
 11.19 GFAP VIM
3
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.7 GFAP SYP VIM
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GO Terms for Clear Cell Ependymoma

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Biological processes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 GFAP VIM
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Sources for Clear Cell Ependymoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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