MCID: CLR011
MIFTS: 34

Clear Cell Ependymoma

Categories: Cancer diseases

Aliases & Classifications for Clear Cell Ependymoma

MalaCards integrated aliases for Clear Cell Ependymoma:

Name: Clear Cell Ependymoma 12 55 15
Cellular Ependymoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5507

Summaries for Clear Cell Ependymoma

MalaCards based summary : Clear Cell Ependymoma, also known as cellular ependymoma, is related to ependymoma and hemangioblastoma. An important gene associated with Clear Cell Ependymoma is VIM (Vimentin), and among its related pathways/superpathways are Neuroscience and Spinal Cord Injury. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, cerebellum and medulla oblongata, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Clear Cell Ependymoma

Diseases related to Clear Cell Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 ependymoma 31.1 ENO2 GFAP MUC1 NF2 RELA SYP
2 hemangioblastoma 30.7 ENO2 GFAP MUC1 SYP
3 oligodendroglioma 29.5 ENO2 GFAP OLIG2 SYP TP53
4 desmoplastic infantile ganglioglioma 11.0 GFAP SYP
5 extraventricular neurocytoma 11.0 GFAP SYP
6 ureter small cell carcinoma 11.0 ENO2 SYP
7 lung combined type small cell carcinoma 11.0 GFAP SYP
8 primary hepatic neuroendocrine carcinoma 11.0 SYP VIM
9 malignant sertoli cell tumor 11.0 ENO2 SYP
10 urinary bladder small cell neuroendocrine carcinoma 11.0 ENO2 SYP
11 bednar tumor 10.9 ENO2 VIM
12 pilomatrix carcinoma 10.9 ENO2 MUC1
13 auditory system cancer 10.9 ENO2 SYP
14 cutaneous leiomyosarcoma 10.9 GFAP MUC1
15 sensory organ benign neoplasm 10.9 ENO2 SYP
16 gallbladder small cell carcinoma 10.9 ENO2 SYP
17 melanotic medulloblastoma 10.9 ENO2 GFAP
18 gangliocytoma 10.9 GFAP SYP
19 pancreatic somatostatinoma 10.9 ENO2 SYP
20 cutaneous ganglioneuroma 10.9 ENO2 SYP
21 extrahepatic bile duct adenocarcinoma 10.9 ENO2 SYP
22 small cell carcinoma of the bladder 10.9 ENO2 SYP
23 epulis 10.9 ENO2 VIM
24 orbital cancer 10.9 ENO2 SYP
25 ovarian carcinosarcoma 10.9 ENO2 SYP
26 pilomyxoid astrocytoma 10.9 GFAP SYP
27 epithelioid leiomyosarcoma 10.9 ENO2 VIM
28 cerebellar medulloblastoma 10.8 ENO2 GFAP
29 malignant mixed mullerian tumor 10.8 MUC1 VIM
30 epithelioid malignant peripheral nerve sheath tumor 10.8 ENO2 MUC1
31 microcystic adenoma 10.8 ENO2 MUC1
32 frontal convexity meningioma 10.8 GFAP TP53
33 nodular hidradenoma 10.8 MUC1 VIM
34 pulmonary large cell neuroendocrine carcinoma 10.8 ENO2 SYP
35 gliofibroma 10.8 GFAP TP53
36 angiocentric glioma 10.8 GFAP SYP VIM
37 medulloepithelioma 10.8 GFAP SYP VIM
38 clear cell meningioma 10.8 GFAP MUC1
39 eccrine porocarcinoma 10.8 MUC1 VIM
40 parachordoma 10.8 GFAP MUC1 VIM
41 syringocystadenoma papilliferum 10.8 GFAP MUC1 VIM
42 perivascular epithelioid cell tumor 10.8 MUC1 SYP VIM
43 primitive neuroectodermal tumor of the cervix uteri 10.8 ENO2 GFAP VIM
44 myxopapillary ependymoma 10.8 GFAP MUC1 VIM
45 protoplasmic astrocytoma 10.8 GFAP TP53
46 sertoli cell tumor 10.8 MUC1 SYP VIM
47 syringoma 10.8 GFAP MUC1 VIM
48 rhabdoid cancer 10.8 MUC1 SYP VIM
49 endometrial mucinous adenocarcinoma 10.8 MUC1 VIM
50 perineurioma 10.8 GFAP MUC1 VIM

Graphical network of the top 20 diseases related to Clear Cell Ependymoma:



Diseases related to Clear Cell Ependymoma

Symptoms & Phenotypes for Clear Cell Ependymoma

GenomeRNAi Phenotypes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 TP53

MGI Mouse Phenotypes related to Clear Cell Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.14 SYP TP53 GFAP MAP2 ADGRV1 NF2
2 mortality/aging MP:0010768 10.1 FANCL TP53 GFAP MAP2 ADGRV1 NF2
3 cellular MP:0005384 10.07 EPB41L3 RELA FANCL GFAP TP53 CD34
4 nervous system MP:0003631 9.97 SYP TP53 GFAP MAP2 ADGRV1 NF2
5 neoplasm MP:0002006 9.73 EPB41L3 TP53 CD34 NF2 OLIG2 YAP1
6 respiratory system MP:0005388 9.5 RELA TP53 NF2 OLIG2 ENO2 VIM
7 vision/eye MP:0005391 9.28 FANCL TP53 GFAP ADGRV1 NF2 CFH

Drugs & Therapeutics for Clear Cell Ependymoma

Drugs for Clear Cell Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1

Search NIH Clinical Center for Clear Cell Ependymoma

Genetic Tests for Clear Cell Ependymoma

Anatomical Context for Clear Cell Ependymoma

MalaCards organs/tissues related to Clear Cell Ependymoma:

41
Spinal Cord, Cerebellum, Medulla Oblongata, Bone, Temporal Lobe

Publications for Clear Cell Ependymoma

Articles related to Clear Cell Ependymoma:

(show all 28)
# Title Authors Year
1
A case of clear cell ependymoma with bizarre aggressiveness: Are we underestimating its ferocity? ( 28879912 )
2017
2
Clear cell ependymoma with late leptomeningeal and supratentorial metastases. ( 26431995 )
2015
3
Clear cell ependymoma in a dog. ( 23273584 )
2013
4
Clear cell ependymoma with trisomy 19 developing bone metastases. ( 22207400 )
2012
5
Anaplastic clear cell ependymoma of the conus medullaris and cauda equina in a 3-year-old child. ( 22009009 )
2012
6
Supratentorial clear cell ependymoma mimicking oligodendroglioma : case report and review of the literature. ( 22102956 )
2011
7
A case of anaplastic clear-cell ependymoma presenting with high erythropoietin concentration and 1p/19q deletions. ( 21643803 )
2011
8
Intraparenchymal clear cell ependymoma. ( 21713151 )
2011
9
Clear cell ependymoma occurring in the cauda equina. ( 20856665 )
2010
10
Differentiation of clear cell ependymoma of the cerebellum from hemangioblastoma by thallium-201 single photon emission computed tomography-case report-. ( 20035139 )
2009
11
Malignant transformation of supratentorial clear cell ependymoma. ( 18647267 )
2009
12
Clear cell ependymoma of the temporal lobe in a child: a case report. ( 18097199 )
2008
13
Clear cell ependymoma: a mimicker of oligodendroglioma--report of three cases. ( 18248576 )
2008
14
Clear-cell ependymoma: a report of intracortical tumor with significant desmoplasia. ( 18194140 )
2008
15
Trisomy 19 ependymoma, a newly recognized genetico-histological association, including clear cell ependymoma. ( 17626628 )
2007
16
Imaging features of clear-cell ependymoma of the spinal cord. ( 17279401 )
2007
17
Clear-cell ependymoma of the cerebellum: a case report. ( 17614003 )
2007
18
Intramedullary clear cell ependymoma in the thoracic spinal cord: a case with its crush smear and ultrastructural findings. ( 17923743 )
2007
19
[Immunohistochemical study is helpful for the diagnosis of cerebellar clear cell ependymoma with atypical radiological findings--case report]. ( 16277226 )
2005
20
Clear cell ependymoma of the fourth ventricle. ( 15641594 )
2004
21
Case of clear cell ependymoma of medulla oblongata: clinicopathological and immunohistochemical study with literature review. ( 12713564 )
2003
22
Clear cell ependymoma: a clinicopathologic and radiographic analysis of 10 patients. ( 14601094 )
2003
23
Clear cell ependymoma with a lipidized component that developed in the thoracic spinal cord. ( 12870256 )
2003
24
Intramedullary clear cell ependymoma in the cervical spinal cord: case report. ( 11126915 )
2000
25
Cerebellar clear cell ependymoma mimicking hemangioblastoma: its clinical and pathological features. ( 10086492 )
1999
26
[Clear cell ependymoma--a case report]. ( 9621365 )
1998
27
Clear cell ependymoma: a mimic of oligodendroglioma: clinicopathologic and ultrastructural considerations. ( 9236838 )
1997
28
Clear cell ependymoma. A histological variant with diagnostic implications. ( 2477945 )
1989

Variations for Clear Cell Ependymoma

Expression for Clear Cell Ependymoma

Search GEO for disease gene expression data for Clear Cell Ependymoma.

Pathways for Clear Cell Ependymoma

Pathways related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 ENO2 GFAP MAP2 NF2 SYP
2 11.58 GFAP TP53 VIM
3 11.49 MUC1 TP53 VIM
4 10.98 FANCL RELA TP53
5 10.92 GFAP MAP2 OLIG2 SYP VIM

GO Terms for Clear Cell Ependymoma

Cellular components related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.47 ADGRV1 CD34 ENO2 EPB41L3 FANCL GFAP
2 cell body GO:0044297 9.13 GFAP MAP2 NF2

Biological processes related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MUC1 RELA TP53 VIM
2 astrocyte development GO:0014002 9.43 GFAP VIM
3 intermediate filament organization GO:0045109 9.4 GFAP VIM
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.32 MUC1 TP53
5 regulation of stem cell proliferation GO:0072091 9.26 NF2 YAP1
6 Bergmann glial cell differentiation GO:0060020 9.16 GFAP VIM
7 cellular response to organic substance GO:0071310 9.13 CD68 MAP2 SYP
8 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 EPB41L3 GFAP VIM
2 structural molecule activity GO:0005198 8.92 EPB41L3 GFAP MAP2 VIM

Sources for Clear Cell Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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