MCID: CLR018
MIFTS: 31

Clear Cell Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Meningioma

MalaCards integrated aliases for Clear Cell Meningioma:

Name: Clear Cell Meningioma 12 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:4210
MeSH 44 D008579
NCIt 50 C4722
SNOMED-CT 68 57606003
UMLS 72 C0431121

Summaries for Clear Cell Meningioma

MalaCards based summary : Clear Cell Meningioma is related to secretory meningioma and spinal meningioma. An important gene associated with Clear Cell Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways are Neuroscience and Signaling by ERBB4. The drugs Trabectedin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary.

Related Diseases for Clear Cell Meningioma

Diseases related to Clear Cell Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 211)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 32.0 VIM MUC1
2 spinal meningioma 31.3 SMARCE1 PGR CHGA
3 olfactory groove meningioma 30.3 PGR CHGA
4 meningioma, familial 30.1 SMARCE1 PGR MKI67 GFAP
5 pleomorphic xanthoastrocytoma 29.8 GFAP CHGA
6 clear cell ependymoma 29.7 VIM MUC1 GFAP
7 hemangioblastoma 29.5 S100B MUC1 GFAP
8 neurilemmoma 29.3 VIM S100B GFAP
9 chordoma 29.0 VIM S100B MUC1 GFAP
10 meningioma, radiation-induced 28.6 VIM S100B PGR MUC1 MKI67 GFAP
11 ependymoma 28.2 VIM S100B MUC1 MKI67 GFAP
12 chordoid meningioma 28.0 VIM S100B MUC1 GFAP CHGA
13 brainstem intraparenchymal clear cell meningioma 12.6
14 spinal multifocal clear cell meningioma 12.5
15 lymphoplasmacyte-rich meningioma 10.9
16 malignant peritoneal mesothelioma 10.5 VIM MUC1
17 papillary tumor of the pineal region 10.5 VIM MUC1
18 nodular hidradenoma 10.5 VIM MUC1
19 hidradenoma 10.5 VIM MUC1
20 biphasic synovial sarcoma 10.5 VIM MUC1
21 adenofibroma 10.5 VIM MUC1
22 desmoplastic small round cell tumor 10.4 VIM MUC1
23 reticulum cell sarcoma 10.4 VIM MUC1
24 extraskeletal ewing sarcoma 10.4 VIM MUC1
25 mesenchymal chondrosarcoma 10.4 VIM MUC1
26 chondroid chordoma 10.4 VIM MUC1
27 mucinous cystadenocarcinoma 10.4 VIM MUC1
28 pancreatoblastoma 10.4 MUC1 CHGA
29 sinonasal undifferentiated carcinoma 10.4 MUC1 MKI67
30 cystadenocarcinoma 10.4 PGR MUC1
31 breast mucoepidermoid carcinoma 10.4 PGR MUC1
32 breast scirrhous carcinoma 10.4 PGR MUC1
33 endosalpingiosis 10.4 PGR MUC1
34 apocrine adenocarcinoma 10.4 PGR MUC1
35 gastric cardia carcinoma 10.4 MUC1 CHGA
36 lymphangiomatosis 10.4 VIM PGR
37 syndrome of inappropriate antidiuretic hormone 10.4 VIM CHGA
38 endodermal sinus tumor 10.3 VIM CHGA
39 epulis 10.3 VIM PGR
40 benign metastasizing leiomyoma 10.3 VIM PGR
41 ameloblastic carcinoma 10.3 VIM MKI67
42 pericardial mesothelioma 10.3 VIM MUC1
43 cystic nephroma 10.3 VIM PGR
44 mixed ductal-endocrine carcinoma 10.3 MUC1 CHGA
45 sertoli-leydig cell tumor 10.3 PGR MUC1
46 gastric tubular adenocarcinoma 10.3 MUC1 CHGA
47 acinar cell cystadenocarcinoma 10.3 MKI67 CHGA
48 osteofibrous dysplasia 10.3 VIM MUC1
49 sclerosing perineurioma 10.3 S100B MUC1
50 localized hypertrophic neuropathy 10.3 S100B MUC1

Graphical network of the top 20 diseases related to Clear Cell Meningioma:



Diseases related to Clear Cell Meningioma

Symptoms & Phenotypes for Clear Cell Meningioma

Drugs & Therapeutics for Clear Cell Meningioma

Drugs for Clear Cell Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2 Alkylating Agents Phase 2
3 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trabectedin for Recurrent Grade II or III Meningioma: a Randomized Phase II Study of the EORTC Brain Tumor Group Completed NCT02234050 Phase 2 Trabectedin
2 Exploring Outcomes and Risk in Patients With Rare Central Nervous System Tumors Recruiting NCT03251989

Search NIH Clinical Center for Clear Cell Meningioma

Genetic Tests for Clear Cell Meningioma

Anatomical Context for Clear Cell Meningioma

MalaCards organs/tissues related to Clear Cell Meningioma:

41
Brain, Bone, Pituitary

Publications for Clear Cell Meningioma

Articles related to Clear Cell Meningioma:

(show top 50) (show all 117)
# Title Authors PMID Year
1
Clinical features and surgical outcomes of spinal clear cell meningioma: An institutional experience. 38
31416737 2019
2
[Persistent chest pain for 4 months and progressive lower limb weakness for 2 months in a boy]. 38
31416509 2019
3
Resection of a Dumbbell Skull Base Meningioma by a Combined Two-Staged Retrosigmoid and Transzygomatic Transcavernous Approach. 38
31143600 2019
4
Meningiomas with Collagenous Rosettes: A Report of Three Cases. 38
31143285 2019
5
Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features. 38
30882396 2019
6
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. 38
30342264 2019
7
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. 38
30384120 2018
8
Two novel cases of spinal clear cell meningioma with vertebra involvement. 38
30545721 2018
9
Prognostic Factors, Survival, and Treatment for Intracranial World Health Organization Grade II Chordoid Meningiomas and Clear-Cell Meningiomas. 38
29859361 2018
10
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. 38
28474749 2018
11
Pediatric nondura-based clear cell meningioma of the cauda equina: case report and review of literature. 38
29363346 2018
12
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. 38
28680293 2017
13
Cisterna magna meningiomas without dural attachment: Report of two cases. 38
28279513 2017
14
SMARCE1 mutation screening in classification of clear cell meningiomas. 38
27891692 2017
15
Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature. 38
28484556 2017
16
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. 38
27787647 2017
17
Intracranial Clear Cell Meningiomas: Study on Clinical Features and Predictors of Recurrence. 38
27744084 2017
18
Suprasellar Clear Cell Meningioma in an Infant. 38
27606120 2016
19
Osteolytic clear cell meningioma of the petrous bone occurring 36 years after posterior cranial fossa irradiation: Case report. 38
27375148 2016
20
Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution. 38
26573513 2016
21
A five year-old child with clear cell petro-clival meningioma: case report with clinical and histopathological long-term follow-up. 38
26077595 2015
22
SMARCE1 mutations in pediatric clear cell meningioma: case report. 38
26114992 2015
23
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology. 38
25431204 2015
24
Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. 38
25249420 2015
25
Intrasellar Clear Cell Meningioma Mimicking Invasive Pituitary Adenoma: A Case Report and Review of the Literature. 38
26617154 2015
26
Clear cell meningioma in a child: A case report and review of literature. 38
25767587 2015
27
Full endoscopic endonasal transclival approach: meningioma attached to the ventral surface of the brainstem. 38
24685579 2014
28
Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. 38
24625613 2014
29
Nondura-based clear cell meningioma of the cauda equina in an adult. 38
22437332 2013
30
A case of clear cell meningioma with tyrosine-rich crystals. 38
23248340 2013
31
An intracranial and intraspinal clear cell meningioma. 38
22727208 2013
32
Differential expression of extracellular matrix-related genes in rare variants of meningioma. 38
22995327 2013
33
Spinal clear cell meningioma in a 3-year-old: a case report. 38
25377168 2013
34
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. 38
22814951 2012
35
[Multifocal clear cell meningioma in the sacral and lumbar spine. Case report and literature review]. 38
22944518 2012
36
Radiation-associated meningiomas in children: clinical, pathological, and cytogenetic characteristics with a critical review of the literature. 38
22900483 2012
37
The optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine: a dynamic positron emission tomography study. 38
22842224 2012
38
Clear cell meningioma with histologically aggressive appearance and clinically aggressive behavior: a case report. 38
22082299 2012
39
Paediatric clear cell meningioma with multiple distant recurrences after presumed intra-operative cell spread. 38
22218777 2012
40
Clear cell meningioma of the cauda equina in an adult. 38
22771665 2012
41
Malignant (anaplastic) transformation of orbital clear cell meningioma. 38
21386740 2012
42
Clear-cell meningioma presenting as an infiltrative external auditory canal mass. 38
27326268 2012
43
[Clinicopathological analysis of clear cell meningioma]. 38
22366024 2012
44
Clear cell meningioma masquerading as trigeminal schwannoma. 38
23050207 2012
45
Intracranial meningeal hemangiopericytoma metastatic to the scapula. 38
22229602 2012
46
Atypical and ischemic features of embolized meningiomas. 38
21789536 2012
47
Ultrastructure of meningiomas: autophagy is involved in the pathogenesis of "intranuclear vacuoles". 38
22773465 2012
48
Meningioma with rhabdoid, papillary and clear cell features: case report and review of association of rare meningioma variants. 38
22011733 2011
49
Intracranial clear cell meningioma: a clinicopathologic study of 15 cases. 38
21643672 2011
50
[Intracranial clear cell meningioma: a clinicopathologic analysis]. 38
22088376 2011

Variations for Clear Cell Meningioma

Expression for Clear Cell Meningioma

Search GEO for disease gene expression data for Clear Cell Meningioma.

Pathways for Clear Cell Meningioma

Pathways related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 S100B MKI67 GFAP
2
Show member pathways
11.17 S100B PGR GFAP
3 10.7 VIM S100B GFAP

GO Terms for Clear Cell Meningioma

Biological processes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.37 VIM GFAP
2 long-term synaptic potentiation GO:0060291 9.32 S100B GFAP
3 intermediate filament organization GO:0045109 9.26 VIM GFAP
4 astrocyte development GO:0014002 9.16 VIM GFAP
5 Bergmann glial cell differentiation GO:0060020 8.96 VIM GFAP
6 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Sources for Clear Cell Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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