MCID: CLR018
MIFTS: 34

Clear Cell Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Meningioma

MalaCards integrated aliases for Clear Cell Meningioma:

Name: Clear Cell Meningioma 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4210
MeSH 43 D008579
NCIt 49 C4722
SNOMED-CT 67 57606003
UMLS 71 C0431121

Summaries for Clear Cell Meningioma

MalaCards based summary : Clear Cell Meningioma is related to secretory meningioma and spinal meningioma. An important gene associated with Clear Cell Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Neuroscience. The drugs Trabectedin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and pituitary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Clear Cell Meningioma

Diseases related to Clear Cell Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 427)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 31.3 VIM TRAF7 NF2 MUC1
2 spinal meningioma 30.8 TRAF7 SMARCE1 SMARCB1 PGR NF2
3 brain meningioma 30.3 TRAF7 NF2
4 monosomy 22 30.3 SMARCB1 NF2
5 olfactory groove meningioma 30.1 TRAF7 SMARCE1 NF2
6 clear cell ependymoma 30.0 VIM SYP MUC1 GFAP
7 oligodendroglioma 29.9 VIM SYP S100B GFAP
8 chordoma 29.9 VIM SMARCB1 S100B MUC1 GFAP
9 meningothelial meningioma 29.8 TRAF7 SMARCE1 PGR NF2
10 benign ependymoma 29.4 VIM SYP S100B NF2 MUC1 GFAP
11 meningioma, radiation-induced 29.3 VIM SUFU SMARCB1 S100B PGR NF2
12 pleomorphic xanthoastrocytoma 29.1 SYP SMARCB1 S100B GFAP CHGA
13 hemangioblastoma 28.8 VIM SYP S100B MUC1 GFAP CD34
14 neurilemmoma 28.4 VIM SMARCB1 S100B NF2 MUC1 GFAP
15 meningioma, familial 27.9 TRAF7 SYP SUFU SMARCE1 SMARCB1 PGR
16 chordoid meningioma 27.0 VIM TRAF7 SYP S100B MUC1 GFAP
17 brainstem intraparenchymal clear cell meningioma 12.6
18 spinal multifocal clear cell meningioma 12.5
19 lymphoplasmacyte-rich meningioma 10.9
20 chronic tympanitis 10.5 PGR MUC1
21 adenofibroma 10.5 VIM MUC1
22 nodular hidradenoma 10.5 VIM MUC1
23 breast scirrhous carcinoma 10.5 PGR MUC1
24 lymphangiomatosis 10.5 VIM PGR
25 lipid-rich breast carcinoma 10.5 PGR MUC1
26 sclerosing perineurioma 10.5 S100B MUC1
27 localized hypertrophic neuropathy 10.5 S100B MUC1
28 reticular perineurioma 10.5 S100B MUC1
29 congenital epulis 10.5 VIM PGR
30 non-functioning pituitary adenoma 10.5 S100B MUC1
31 epulis 10.5 VIM PGR
32 hydromyelia 10.5 VIM S100B
33 aggressive digital papillary adenocarcinoma 10.5 S100B MUC1
34 vaginal glandular tumor 10.5 PGR CHGA
35 bednar tumor 10.5 VIM S100B
36 ewing sarcoma of bone 10.5 VIM CHGA
37 benign metastasizing leiomyoma 10.5 VIM PGR
38 chondroid chordoma 10.5 VIM MUC1
39 pericardial mesothelioma 10.5 VIM MUC1
40 primitive neuroectodermal tumor of the cervix uteri 10.5 VIM GFAP
41 meningeal melanocytoma 10.5 S100B MUC1
42 pancreatic mucinous cystadenoma 10.5 PGR MUC1
43 reticulum cell sarcoma 10.5 VIM MUC1
44 desmoplastic small round cell tumor 10.5 VIM MUC1
45 malignant peritoneal mesothelioma 10.5 NF2 MUC1
46 biphasic synovial sarcoma 10.5 VIM MUC1
47 ameloblastic carcinoma 10.4 VIM MKI67
48 odontogenic myxoma 10.4 VIM S100B
49 endosalpingiosis 10.4 PGR MUC1
50 apocrine adenocarcinoma 10.4 PGR MUC1

Graphical network of the top 20 diseases related to Clear Cell Meningioma:



Diseases related to Clear Cell Meningioma

Symptoms & Phenotypes for Clear Cell Meningioma

GenomeRNAi Phenotypes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

26 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 SMARCB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.77 VIM
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.77 SMARCB1 SMARCE1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.77 CHGA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.77 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.77 CHGA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.77 CHGA SMARCB1 SMARCE1 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.77 SMARCE1 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.77 CHGA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.77 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.77 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.77 SMARCB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.77 CHGA
14 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.77 SMARCE1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.77 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.77 SMARCE1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.77 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.77 CHGA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 SMARCB1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 SMARCB1 VIM
22 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.77 SMARCE1
23 Increased proliferation GR00094-A 8.96 NF2 SMARCB1

MGI Mouse Phenotypes related to Clear Cell Meningioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CD2AP CD34 GFAP NF2 PGR SMARCB1

Drugs & Therapeutics for Clear Cell Meningioma

Drugs for Clear Cell Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2 Alkylating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trabectedin for Recurrent Grade II or III Meningioma: a Randomized Phase II Study of the EORTC Brain Tumor Group Completed NCT02234050 Phase 2 Trabectedin
2 Exploring Outcomes and Risk in Patients With Rare Central Nervous System Tumors Recruiting NCT03251989

Search NIH Clinical Center for Clear Cell Meningioma

Genetic Tests for Clear Cell Meningioma

Anatomical Context for Clear Cell Meningioma

MalaCards organs/tissues related to Clear Cell Meningioma:

40
Breast, Brain, Pituitary, Spinal Cord, Lung, Bone, Small Intestine

Publications for Clear Cell Meningioma

Articles related to Clear Cell Meningioma:

(show top 50) (show all 118)
# Title Authors PMID Year
1
Clinical features and surgical outcomes of spinal clear cell meningioma: An institutional experience. 61
31416737 2019
2
Spinal Clear Cell Meningiomas: Clinical Features and Factors Predicting Recurrence. 61
31765868 2019
3
[Persistent chest pain for 4 months and progressive lower limb weakness for 2 months in a boy]. 61
31416509 2019
4
Resection of a Dumbbell Skull Base Meningioma by a Combined Two-Staged Retrosigmoid and Transzygomatic Transcavernous Approach. 61
31143600 2019
5
Meningiomas with Collagenous Rosettes: A Report of Three Cases. 61
31143285 2019
6
Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features. 61
30882396 2019
7
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. 61
30342264 2019
8
Two novel cases of spinal clear cell meningioma with vertebra involvement. 61
30545721 2018
9
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. 61
30384120 2018
10
Prognostic Factors, Survival, and Treatment for Intracranial World Health Organization Grade II Chordoid Meningiomas and Clear-Cell Meningiomas. 61
29859361 2018
11
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. 61
28474749 2018
12
Pediatric nondura-based clear cell meningioma of the cauda equina: case report and review of literature. 61
29363346 2018
13
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. 61
28680293 2017
14
Cisterna magna meningiomas without dural attachment: Report of two cases. 61
28279513 2017
15
SMARCE1 mutation screening in classification of clear cell meningiomas. 61
27891692 2017
16
Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature. 61
28484556 2017
17
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. 61
27787647 2017
18
Intracranial Clear Cell Meningiomas: Study on Clinical Features and Predictors of Recurrence. 61
27744084 2017
19
Suprasellar Clear Cell Meningioma in an Infant. 61
27606120 2016
20
Osteolytic clear cell meningioma of the petrous bone occurring 36 years after posterior cranial fossa irradiation: Case report. 61
27375148 2016
21
Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution. 61
26573513 2016
22
A five year-old child with clear cell petro-clival meningioma: case report with clinical and histopathological long-term follow-up. 61
26077595 2015
23
SMARCE1 mutations in pediatric clear cell meningioma: case report. 61
26114992 2015
24
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology. 61
25431204 2015
25
Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. 61
25249420 2015
26
Clear cell meningioma in a child: A case report and review of literature. 61
25767587 2015
27
Intrasellar Clear Cell Meningioma Mimicking Invasive Pituitary Adenoma: A Case Report and Review of the Literature. 61
26617154 2015
28
Full endoscopic endonasal transclival approach: meningioma attached to the ventral surface of the brainstem. 61
24685579 2014
29
Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. 61
24625613 2014
30
Nondura-based clear cell meningioma of the cauda equina in an adult. 61
22437332 2013
31
A case of clear cell meningioma with tyrosine-rich crystals. 61
23248340 2013
32
An intracranial and intraspinal clear cell meningioma. 61
22727208 2013
33
Differential expression of extracellular matrix-related genes in rare variants of meningioma. 61
22995327 2013
34
Spinal clear cell meningioma in a 3-year-old: a case report. 61
25377168 2013
35
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. 61
22814951 2012
36
[Multifocal clear cell meningioma in the sacral and lumbar spine. Case report and literature review]. 61
22944518 2012
37
Radiation-associated meningiomas in children: clinical, pathological, and cytogenetic characteristics with a critical review of the literature. 61
22900483 2012
38
The optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine: a dynamic positron emission tomography study. 61
22842224 2012
39
Clear cell meningioma with histologically aggressive appearance and clinically aggressive behavior: a case report. 61
22082299 2012
40
Paediatric clear cell meningioma with multiple distant recurrences after presumed intra-operative cell spread. 61
22218777 2012
41
Clear cell meningioma of the cauda equina in an adult. 61
22771665 2012
42
Malignant (anaplastic) transformation of orbital clear cell meningioma. 61
21386740 2012
43
Clear-cell meningioma presenting as an infiltrative external auditory canal mass. 61
27326268 2012
44
Intracranial meningeal hemangiopericytoma metastatic to the scapula. 61
22229602 2012
45
Clear cell meningioma masquerading as trigeminal schwannoma. 61
23050207 2012
46
[Clinicopathological analysis of clear cell meningioma]. 61
22366024 2012
47
Ultrastructure of meningiomas: autophagy is involved in the pathogenesis of "intranuclear vacuoles". 61
22773465 2012
48
Atypical and ischemic features of embolized meningiomas. 61
21789536 2012
49
Meningioma with rhabdoid, papillary and clear cell features: case report and review of association of rare meningioma variants. 61
22011733 2011
50
Intracranial clear cell meningioma: a clinicopathologic study of 15 cases. 61
21643672 2011

Variations for Clear Cell Meningioma

Expression for Clear Cell Meningioma

Search GEO for disease gene expression data for Clear Cell Meningioma.

Pathways for Clear Cell Meningioma

Pathways related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.05 VIM NF2 MUC1 CD2AP
2 11.89 SYP S100B NF2 MKI67 GFAP
3
Show member pathways
11.53 S100B PGR GFAP
4 11.2 VIM MKI67 CD2AP
5 10.82 VIM SYP S100B GFAP

GO Terms for Clear Cell Meningioma

Cellular components related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ruffle GO:0001726 9.33 S100B NF2 CD2AP
2 SWI/SNF complex GO:0016514 9.32 SMARCE1 SMARCB1
3 nBAF complex GO:0071565 9.26 SMARCE1 SMARCB1
4 perinuclear region of cytoplasm GO:0048471 9.1 SYP S100B NF2 CHGA CD34 CD2AP
5 npBAF complex GO:0071564 8.96 SMARCE1 SMARCB1

Biological processes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of neuronal synaptic plasticity GO:0048168 9.43 SYP S100B
2 nucleosome disassembly GO:0006337 9.4 SMARCE1 SMARCB1
3 intermediate filament organization GO:0045109 9.37 VIM GFAP
4 astrocyte development GO:0014002 9.32 VIM GFAP
5 Bergmann glial cell differentiation GO:0060020 9.26 VIM GFAP
6 paracrine signaling GO:0038001 9.16 PGR CD34
7 positive regulation of histone H4 acetylation GO:0090240 8.96 SMARCB1 MUC1
8 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Molecular functions related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 9.13 VIM GFAP CD2AP
2 identical protein binding GO:0042802 9.1 VIM SYP S100B PGR GFAP CD2AP

Sources for Clear Cell Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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