MCID: CLR018
MIFTS: 32

Clear Cell Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Meningioma

MalaCards integrated aliases for Clear Cell Meningioma:

Name: Clear Cell Meningioma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4210
MeSH 44 D008579
NCIt 50 C4722
SNOMED-CT 68 57606003
UMLS 73 C0431121

Summaries for Clear Cell Meningioma

MalaCards based summary : Clear Cell Meningioma is related to secretory meningioma and spinal meningioma. An important gene associated with Clear Cell Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Trabectedin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and breast, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Clear Cell Meningioma

Diseases related to Clear Cell Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 30.5 MUC1 VIM
2 spinal meningioma 30.1 CHGA PGR SMARCE1
3 meningioma, familial 29.7 GFAP PGR SMARCE1 SNRPB
4 brainstem intraparenchymal clear cell meningioma 12.5
5 spinal multifocal clear cell meningioma 12.3
6 malignant peritoneal mesothelioma 10.2 MUC1 VIM
7 papillary tumor of the pineal region 10.2 MUC1 VIM
8 malignant peripheral nerve sheath tumor 10.2 MUC1 VIM
9 ossifying fibromyxoid tumor 10.2 MUC1 VIM
10 fibrous meningioma 10.2 MUC1 VIM
11 nodular hidradenoma 10.2 MUC1 VIM
12 hidradenoma 10.2 MUC1 VIM
13 eccrine porocarcinoma 10.2 MUC1 VIM
14 bile duct adenoma 10.2 MUC1 VIM
15 biphasic synovial sarcoma 10.2 MUC1 VIM
16 adenofibroma 10.2 MUC1 VIM
17 monophasic synovial sarcoma 10.2 MUC1 VIM
18 pleomorphic liposarcoma 10.2 MUC1 VIM
19 desmoplastic small round cell tumor 10.2 MUC1 VIM
20 reticulum cell sarcoma 10.2 MUC1 VIM
21 mesenchymal chondrosarcoma 10.2 MUC1 VIM
22 extraskeletal ewing sarcoma 10.2 MUC1 VIM
23 mucoepidermoid carcinoma 10.2 CHGA MUC1
24 perineurioma 10.2 MUC1 VIM
25 spindle cell sarcoma 10.2 MUC1 VIM
26 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA MUC1
27 mucinous cystadenocarcinoma 10.2 MUC1 VIM
28 chondroid chordoma 10.1 MUC1 VIM
29 dendritic cell tumor 10.1 MUC1 VIM
30 meningothelial meningioma 10.1 SMARCE1 SNRPB
31 pancreatoblastoma 10.1 CHGA MUC1
32 cerebral primitive neuroectodermal tumor 10.1 MUC1 VIM
33 polymorphous low-grade adenocarcinoma 10.1 MUC1 VIM
34 hemangiopericytoma, malignant 10.1 MUC1 VIM
35 primary hepatic neuroendocrine carcinoma 10.1 CHGA VIM
36 gastric cardia carcinoma 10.1 CHGA MUC1
37 malignant fibroxanthoma 10.1 MUC1 VIM
38 breast mucoepidermoid carcinoma 10.1 MUC1 PGR
39 pericardial mesothelioma 10.1 MUC1 VIM
40 breast scirrhous carcinoma 10.1 MUC1 PGR
41 endosalpingiosis 10.1 MUC1 PGR
42 osteofibrous dysplasia 10.1 MUC1 VIM
43 fasciitis 10.1 MUC1 VIM
44 apocrine adenocarcinoma 10.1 MUC1 PGR
45 rhabdoid tumor predisposition syndrome 1 10.1 MUC1 VIM
46 epithelioid sarcoma 10.1 MUC1 VIM
47 syndrome of inappropriate antidiuretic hormone 10.1 CHGA VIM
48 gastric tubular adenocarcinoma 10.1 CHGA MUC1
49 endodermal sinus tumor 10.1 CHGA VIM
50 mixed ductal-endocrine carcinoma 10.1 CHGA MUC1

Graphical network of the top 20 diseases related to Clear Cell Meningioma:



Diseases related to Clear Cell Meningioma

Symptoms & Phenotypes for Clear Cell Meningioma

GenomeRNAi Phenotypes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.66 VIM
2 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.66 SMARCE1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.66 CHGA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.66 VIM
5 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.66 CHGA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.66 CHGA SMARCE1 VIM
7 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.66 SMARCE1 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.66 CHGA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.66 VIM
10 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.66 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.66 CHGA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.66 SMARCE1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.66 VIM
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.66 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.66 SMARCE1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 VIM
17 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.66 CHGA
18 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 VIM
19 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.66 SMARCE1

Drugs & Therapeutics for Clear Cell Meningioma

Drugs for Clear Cell Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2 Alkylating Agents Phase 2
3 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trabectedin for Recurrent Grade II/III Meningioma Active, not recruiting NCT02234050 Phase 2 Trabectedin
2 Oncological Care for Patients With Meningioma Not yet recruiting NCT02973256

Search NIH Clinical Center for Clear Cell Meningioma

Genetic Tests for Clear Cell Meningioma

Anatomical Context for Clear Cell Meningioma

MalaCards organs/tissues related to Clear Cell Meningioma:

41
Brain, Pituitary, Breast, Ovary, Spinal Cord, Cervix, Smooth Muscle

Publications for Clear Cell Meningioma

Articles related to Clear Cell Meningioma:

(show top 50) (show all 82)
# Title Authors Year
1
Pediatric nondura-based clear cell meningioma of the cauda equina: case report and review of literature. ( 29363346 )
2018
2
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. ( 30342264 )
2018
3
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. ( 30384120 )
2018
4
Two novel cases of spinal clear cell meningioma with vertebra involvement. ( 30545721 )
2018
5
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. ( 28474749 )
2017
6
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. ( 28680293 )
2017
7
Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature. ( 28484556 )
2017
8
Clear cell meningioma: A case report with review of the literature. ( 27773164 )
2016
9
Osteolytic clear cell meningioma of the petrous bone occurring 36 years after posterior cranial fossa irradiation: Case report. ( 27375148 )
2016
10
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. ( 27787647 )
2016
11
Suprasellar Clear Cell Meningioma in an Infant. ( 27606120 )
2016
12
Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution. ( 26573513 )
2015
13
SMARCE1 mutations in pediatric clear cell meningioma: case report. ( 26114992 )
2015
14
Intrasellar Clear Cell Meningioma Mimicking Invasive Pituitary Adenoma: A Case Report and Review of the Literature. ( 26617154 )
2015
15
Clear cell meningioma in a child: A case report and review of literature. ( 25767587 )
2015
16
Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. ( 24625613 )
2014
17
Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. ( 25249420 )
2014
18
Spinal Clear Cell Meningioma in a 3-Year-Old: A Case Report. ( 25377168 )
2014
19
A case of clear cell meningioma with tyrosine-rich crystals. ( 23248340 )
2013
20
Nondura-based clear cell meningioma of the cauda equina in an adult. ( 22437332 )
2013
21
An intracranial and intraspinal clear cell meningioma. ( 22727208 )
2013
22
Malignant (anaplastic) transformation of orbital clear cell meningioma. ( 21386740 )
2012
23
Clear cell meningioma masquerading as trigeminal schwannoma. ( 23050207 )
2012
24
Clear-cell meningioma presenting as an infiltrative external auditory canal mass. ( 27326268 )
2012
25
Clear cell meningioma of the cauda equina in an adult. ( 22771665 )
2012
26
Clear cell meningioma with histologically aggressive appearance and clinically aggressive behavior: a case report. ( 22082299 )
2012
27
Paediatric clear cell meningioma with multiple distant recurrences after presumed intra-operative cell spread. ( 22218777 )
2012
28
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. ( 22814951 )
2012
29
Intracranial clear cell meningioma: a clinicopathologic study of 15 cases. ( 21643672 )
2011
30
Non-dura based intaspinal clear cell meningioma. ( 21494369 )
2011
31
Clear cell meningioma with frequent chordoid features and aggressive behavior: a clinicopathologic study of ten cases at a single institution. ( 20872042 )
2011
32
The cytology of intracranial clear cell meningioma with an unusual scalp presentation. ( 21897546 )
2011
33
Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma. ( 20453815 )
2010
34
Clear cell meningioma of the fourth ventricle in a child: a case report and literature review. ( 21540624 )
2010
35
Supratentorial clear cell meningioma in a child: A rare tumor at unusual location. ( 21559163 )
2010
36
Clear cell meningioma causing Castleman syndrome in a child. ( 20515337 )
2010
37
Clear cell meningioma with anaplastic features: case report and review of literature. ( 19857933 )
2010
38
[Report of seven cases of clear-cell meningioma and a literature review]. ( 20451062 )
2010
39
An unusual case of clear cell meningioma. ( 20160375 )
2009
40
Extradural middle fossa approach to a clear cell meningioma in a child. ( 19378726 )
2009
41
Posterior fossa clear cell meningioma without dural attachment in a child. ( 19030867 )
2009
42
Clear-cell meningioma of the anterior cranial fossa. Case report and review of the literature. ( 20075823 )
2009
43
Intracranial clear-cell meningioma. ( 19277460 )
2009
44
Clear cell meningioma presenting as rapidly deteriorating visual field and acuity during pregnancy. ( 19632846 )
2009
45
Pediatric spinal clear cell meningioma. Case report. ( 19119906 )
2009
46
Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis. ( 18193452 )
2008
47
An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report. ( 18514392 )
2008
48
Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. ( 16955223 )
2007
49
An unusual case of cervical clear-cell meningioma in pediatric age. ( 17021731 )
2007
50
Frontotemporal clear cell meningioma. Report of 3 cases. ( 17498592 )
2007

Variations for Clear Cell Meningioma

Expression for Clear Cell Meningioma

Search GEO for disease gene expression data for Clear Cell Meningioma.

Pathways for Clear Cell Meningioma

Pathways related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 GFAP VIM

GO Terms for Clear Cell Meningioma

Biological processes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 MUC1 PGR SMARCE1

Sources for Clear Cell Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....