MCID: CLR018
MIFTS: 32

Clear Cell Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Meningioma

MalaCards integrated aliases for Clear Cell Meningioma:

Name: Clear Cell Meningioma 12 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4210
MeSH 45 D008579
NCIt 51 C4722
SNOMED-CT 69 57606003
UMLS 74 C0431121

Summaries for Clear Cell Meningioma

MalaCards based summary : Clear Cell Meningioma is related to secretory meningioma and spinal meningioma. An important gene associated with Clear Cell Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Trabectedin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include pituitary, breast and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Clear Cell Meningioma

Diseases related to Clear Cell Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 31.5 MUC1 VIM
2 spinal meningioma 30.9 CHGA PGR SMARCE1
3 meningioma, familial 30.2 GFAP PGR SMARCE1 SNRPB
4 neurilemmoma 29.6 GFAP VIM
5 brainstem intraparenchymal clear cell meningioma 12.5
6 spinal multifocal clear cell meningioma 12.4
7 malignant peritoneal mesothelioma 10.3 MUC1 VIM
8 papillary tumor of the pineal region 10.3 MUC1 VIM
9 malignant peripheral nerve sheath tumor 10.2 MUC1 VIM
10 ossifying fibromyxoid tumor 10.2 MUC1 VIM
11 fibrous meningioma 10.2 MUC1 VIM
12 nodular hidradenoma 10.2 MUC1 VIM
13 hidradenoma 10.2 MUC1 VIM
14 eccrine porocarcinoma 10.2 MUC1 VIM
15 biphasic synovial sarcoma 10.2 MUC1 VIM
16 adenofibroma 10.2 MUC1 VIM
17 monophasic synovial sarcoma 10.2 MUC1 VIM
18 meningothelial meningioma 10.2 SMARCE1 SNRPB
19 pleomorphic liposarcoma 10.2 MUC1 VIM
20 desmoplastic small round cell tumor 10.2 MUC1 VIM
21 reticulum cell sarcoma 10.2 MUC1 VIM
22 mesenchymal chondrosarcoma 10.2 MUC1 VIM
23 extraskeletal ewing sarcoma 10.2 MUC1 VIM
24 mucoepidermoid carcinoma 10.2 CHGA MUC1
25 perineurioma 10.2 MUC1 VIM
26 spindle cell sarcoma 10.2 MUC1 VIM
27 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA MUC1
28 mucinous cystadenocarcinoma 10.2 MUC1 VIM
29 chondroid chordoma 10.2 MUC1 VIM
30 dendritic cell tumor 10.2 MUC1 VIM
31 pancreatoblastoma 10.2 CHGA MUC1
32 primary hepatic neuroendocrine carcinoma 10.2 CHGA VIM
33 cerebral primitive neuroectodermal tumor 10.2 MUC1 VIM
34 polymorphous low-grade adenocarcinoma 10.2 MUC1 VIM
35 hemangiopericytoma, malignant 10.2 MUC1 VIM
36 gastric cardia carcinoma 10.2 CHGA MUC1
37 malignant fibroxanthoma 10.2 MUC1 VIM
38 breast mucoepidermoid carcinoma 10.2 MUC1 PGR
39 breast scirrhous carcinoma 10.2 MUC1 PGR
40 pericardial mesothelioma 10.2 MUC1 VIM
41 endosalpingiosis 10.2 MUC1 PGR
42 syndrome of inappropriate antidiuretic hormone 10.2 CHGA VIM
43 endodermal sinus tumor 10.2 CHGA VIM
44 osteofibrous dysplasia 10.2 MUC1 VIM
45 apocrine adenocarcinoma 10.1 MUC1 PGR
46 rhabdoid tumor predisposition syndrome 1 10.1 MUC1 VIM
47 benign meningioma 10.1 PGR SMARCE1
48 epithelioid sarcoma 10.1 MUC1 VIM
49 lymphangiomatosis 10.1 PGR VIM
50 gastric tubular adenocarcinoma 10.1 CHGA MUC1

Graphical network of the top 20 diseases related to Clear Cell Meningioma:



Diseases related to Clear Cell Meningioma

Symptoms & Phenotypes for Clear Cell Meningioma

GenomeRNAi Phenotypes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

27 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.72 VIM
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.72 CHGA SMARCE1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.72 SMARCE1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.72 CHGA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.72 VIM
6 Increased shRNA abundance (Z-score > 2) GR00366-A-174 9.72 CHGA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.72 CHGA SMARCE1 VIM
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.72 SMARCE1 VIM
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.72 CHGA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.72 VIM
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.72 VIM
12 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.72 CHGA
13 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.72 SMARCE1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.72 VIM
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.72 VIM
16 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.72 SMARCE1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 VIM
18 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.72 CHGA
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.72 CHGA
20 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 VIM
21 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.72 SMARCE1

Drugs & Therapeutics for Clear Cell Meningioma

Drugs for Clear Cell Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2 Alkylating Agents Phase 2
3 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trabectedin for Recurrent Grade II/III Meningioma Completed NCT02234050 Phase 2 Trabectedin
2 Oncological Care for Patients With Meningioma Not yet recruiting NCT02973256

Search NIH Clinical Center for Clear Cell Meningioma

Genetic Tests for Clear Cell Meningioma

Anatomical Context for Clear Cell Meningioma

MalaCards organs/tissues related to Clear Cell Meningioma:

42
Pituitary, Breast, Ovary, Bone, Spinal Cord, Cervix, Smooth Muscle

Publications for Clear Cell Meningioma

Articles related to Clear Cell Meningioma:

(show top 50) (show all 81)
# Title Authors Year
1
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. ( 30342264 )
2019
2
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. ( 28474749 )
2018
3
Pediatric nondura-based clear cell meningioma of the cauda equina: case report and review of literature. ( 29363346 )
2018
4
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. ( 30384120 )
2018
5
Two novel cases of spinal clear cell meningioma with vertebra involvement. ( 30545721 )
2018
6
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. ( 27787647 )
2017
7
Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature. ( 28484556 )
2017
8
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. ( 28680293 )
2017
9
Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution. ( 26573513 )
2016
10
Osteolytic clear cell meningioma of the petrous bone occurring 36 years after posterior cranial fossa irradiation: Case report. ( 27375148 )
2016
11
Suprasellar Clear Cell Meningioma in an Infant. ( 27606120 )
2016
12
Intrasellar Clear Cell Meningioma Mimicking Invasive Pituitary Adenoma: A Case Report and Review of the Literature. ( 26617154 )
2015
13
Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. ( 25249420 )
2015
14
Clear cell meningioma in a child: A case report and review of literature. ( 25767587 )
2015
15
SMARCE1 mutations in pediatric clear cell meningioma: case report. ( 26114992 )
2015
16
Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. ( 24625613 )
2014
17
Nondura-based clear cell meningioma of the cauda equina in an adult. ( 22437332 )
2013
18
An intracranial and intraspinal clear cell meningioma. ( 22727208 )
2013
19
A case of clear cell meningioma with tyrosine-rich crystals. ( 23248340 )
2013
20
Spinal clear cell meningioma in a 3-year-old: a case report. ( 25377168 )
2013
21
Malignant (anaplastic) transformation of orbital clear cell meningioma. ( 21386740 )
2012
22
Clear cell meningioma with histologically aggressive appearance and clinically aggressive behavior: a case report. ( 22082299 )
2012
23
Paediatric clear cell meningioma with multiple distant recurrences after presumed intra-operative cell spread. ( 22218777 )
2012
24
Clear cell meningioma of the cauda equina in an adult. ( 22771665 )
2012
25
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. ( 22814951 )
2012
26
Clear cell meningioma masquerading as trigeminal schwannoma. ( 23050207 )
2012
27
Clear-cell meningioma presenting as an infiltrative external auditory canal mass. ( 27326268 )
2012
28
Clear cell meningioma with frequent chordoid features and aggressive behavior: a clinicopathologic study of ten cases at a single institution. ( 20872042 )
2011
29
Non-dura based intaspinal clear cell meningioma. ( 21494369 )
2011
30
Intracranial clear cell meningioma: a clinicopathologic study of 15 cases. ( 21643672 )
2011
31
The cytology of intracranial clear cell meningioma with an unusual scalp presentation. ( 21897546 )
2011
32
Clear cell meningioma with anaplastic features: case report and review of literature. ( 19857933 )
2010
33
Clear cell meningioma: a clinicopathologic study of 18 tumors and examination of the use of CD10, CA9, and RCC antibodies to distinguish between clear cell meningioma and metastatic clear cell renal cell carcinoma. ( 20453815 )
2010
34
Clear cell meningioma causing Castleman syndrome in a child. ( 20515337 )
2010
35
Clear cell meningioma of the fourth ventricle in a child: a case report and literature review. ( 21540624 )
2010
36
Supratentorial clear cell meningioma in a child: A rare tumor at unusual location. ( 21559163 )
2010
37
[Report of seven cases of clear-cell meningioma and a literature review]. ( 20451062 )
2010
38
Clear-cell meningioma of the anterior cranial fossa. Case report and review of the literature. ( 20075823 )
2009
39
An unusual case of clear cell meningioma. ( 20160375 )
2009
40
Posterior fossa clear cell meningioma without dural attachment in a child. ( 19030867 )
2009
41
Pediatric spinal clear cell meningioma. Case report. ( 19119906 )
2009
42
Intracranial clear-cell meningioma. ( 19277460 )
2009
43
Extradural middle fossa approach to a clear cell meningioma in a child. ( 19378726 )
2009
44
Clear cell meningioma presenting as rapidly deteriorating visual field and acuity during pregnancy. ( 19632846 )
2009
45
Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis. ( 18193452 )
2008
46
An intraventricular clear cell meningioma revealed by an inflammatory syndrome in a male adult: a case report. ( 18514392 )
2008
47
Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. ( 16955223 )
2007
48
An unusual case of cervical clear-cell meningioma in pediatric age. ( 17021731 )
2007
49
Frontotemporal clear cell meningioma. Report of 3 cases. ( 17498592 )
2007
50
Intramedullary clear cell meningioma. ( 16341630 )
2006

Variations for Clear Cell Meningioma

Expression for Clear Cell Meningioma

Search GEO for disease gene expression data for Clear Cell Meningioma.

Pathways for Clear Cell Meningioma

Pathways related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 GFAP VIM

GO Terms for Clear Cell Meningioma

Biological processes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 intermediate filament organization GO:0045109 9.26 GFAP VIM
3 astrocyte development GO:0014002 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 8.8 MUC1 PGR SMARCE1

Sources for Clear Cell Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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