MCID: CLR018
MIFTS: 30

Clear Cell Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Clear Cell Meningioma

MalaCards integrated aliases for Clear Cell Meningioma:

Name: Clear Cell Meningioma 12 15 17 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4210
MeSH 44 D008579
NCIt 50 C4722
SNOMED-CT 67 134213009
UMLS 71 C0431121

Summaries for Clear Cell Meningioma

MalaCards based summary : Clear Cell Meningioma is related to spinal meningioma and secretory meningioma. An important gene associated with Clear Cell Meningioma is SMARCE1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1), and among its related pathways/superpathways are Neuroscience and Signaling by ERBB4. Affiliated tissues include brain and pituitary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Clear Cell Meningioma

Diseases related to Clear Cell Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 31.0 TRAF7 SMARCE1 SMARCB1 PGR NF2
2 secretory meningioma 30.8 VIM TRAF7 SMARCE1 SMARCB1 NF2 MUC1
3 intracranial meningioma 30.4 PGR MKI67
4 benign ependymoma 30.3 SYP NF2 GFAP
5 monosomy 22 30.2 SMARCB1 NF2
6 olfactory groove meningioma 30.1 TRAF7 PGR NF2
7 brain meningioma 30.1 TRAF7 PGR NF2
8 cauda equina syndrome 30.1 SYP GFAP
9 chordoma 30.0 VIM SMARCB1 S100B MUC1 GFAP
10 intravenous leiomyomatosis 30.0 PGR CD34
11 adenoma 29.8 SYP MUC1 MKI67 CHGA
12 clear cell ependymoma 29.7 VIM SYP NF2 MUC1 GFAP
13 cellular ependymoma 29.7 VIM SYP S100B NF2 MUC1 GFAP
14 central neurocytoma 29.7 SYP MKI67 GFAP CHGA
15 pleomorphic xanthoastrocytoma 29.3 SYP SMARCB1 S100B GFAP CHGA
16 hemangioblastoma 29.3 VIM SYP S100B MUC1 GFAP CD34
17 hemangiopericytoma, malignant 29.2 VIM SYP S100B MUC1 CD34
18 neurilemmoma 28.9 VIM SMARCB1 S100B NF2 MUC1 GFAP
19 meningioma, familial 28.2 VIM TRAF7 SYP SMARCE1 SMARCB1 S100B
20 brainstem intraparenchymal clear cell meningioma 11.5
21 spinal multifocal clear cell meningioma 11.5
22 lymphoplasmacyte-rich meningioma 10.9
23 chronic tympanitis 10.4 PGR MUC1
24 nodular hidradenoma 10.4 VIM MUC1
25 lipid-rich breast carcinoma 10.4 PGR MUC1
26 breast scirrhous carcinoma 10.4 PGR MUC1
27 lymphangiomatosis 10.4 VIM PGR
28 sclerosing perineurioma 10.4 S100B MUC1
29 localized hypertrophic neuropathy 10.4 S100B MUC1
30 reticular perineurioma 10.4 S100B MUC1
31 hydromyelia 10.4 VIM S100B
32 congenital epulis 10.4 VIM PGR
33 epulis 10.4 VIM PGR
34 aggressive digital papillary adenocarcinoma 10.4 S100B MUC1
35 bednar tumor 10.4 VIM S100B
36 benign metastasizing leiomyoma 10.4 VIM PGR
37 meningeal melanocytoma 10.4 S100B MUC1
38 vaginal glandular tumor 10.4 PGR CHGA
39 cerebral primitive neuroectodermal tumor 10.4 S100B MUC1
40 chondroid chordoma 10.4 VIM MUC1
41 primitive neuroectodermal tumor of the cervix uteri 10.4 VIM GFAP
42 ewing sarcoma of bone 10.4 VIM CHGA
43 non-functioning pituitary adenoma 10.4 S100B MUC1
44 pancreatic mucinous cystadenoma 10.4 PGR MUC1
45 pericardial mesothelioma 10.4 VIM MUC1
46 reticulum cell sarcoma 10.4 VIM MUC1
47 malignant peritoneal mesothelioma 10.3 NF2 MUC1
48 ameloblastic carcinoma 10.3 VIM MKI67
49 solid adenocarcinoma with mucin production 10.3 MUC1 CHGA
50 mn1 c-terminal truncation syndrome 10.3 SMARCE1 NF2

Graphical network of the top 20 diseases related to Clear Cell Meningioma:



Diseases related to Clear Cell Meningioma

Symptoms & Phenotypes for Clear Cell Meningioma

GenomeRNAi Phenotypes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 10.07 SMARCB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 10.07 SMARCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 10.07 SMARCE1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 10.07 SMARCB1 SMARCE1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 10.07 CHGA
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.07 VIM
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 10.07 VIM
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-174 10.07 CHGA
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 10.07 CHGA VIM
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-190 10.07 VIM
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 10.07 VIM
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-215 10.07 CHGA
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.07 SMARCE1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 10.07 VIM
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-30 10.07 VIM
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 10.07 SMARCB1
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.07 SMARCE1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 10.07 CHGA
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-70 10.07 CHGA
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-83 10.07 SMARCB1
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 10.07 SMARCB1 VIM
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 10.07 VIM
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 10.07 SMARCE1
24 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

Drugs & Therapeutics for Clear Cell Meningioma

Search Clinical Trials , NIH Clinical Center for Clear Cell Meningioma

Genetic Tests for Clear Cell Meningioma

Anatomical Context for Clear Cell Meningioma

MalaCards organs/tissues related to Clear Cell Meningioma:

40
Brain, Pituitary

Publications for Clear Cell Meningioma

Articles related to Clear Cell Meningioma:

(show top 50) (show all 128)
# Title Authors PMID Year
1
Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1. 61
33319313 2021
2
Clear cell histology portends a worse prognosis than other WHO grade II histologies. 61
33398533 2021
3
The use of radiolucent (carbon fibre-reinforced polymer) pedicle screw fixation for serial monitoring of clear cell meningioma: a case report. 61
33365123 2020
4
Paediatric supra- and infratentorial multiple giant clear cell meningioma: A report of a rare case and review of the literature. 61
33216172 2020
5
Familial Pediatric Clear Cell Meningioma With Germline SMARCE1 Mutation in the United States. 61
33085974 2020
6
The importance of genetic counseling and screening for people with pathogenic SMARCE1 variants: A family study. 61
33185983 2020
7
Rare intraspinal clear cell meningioma in children: a case report and literature review. 61
33135529 2020
8
Clear Cell Meningioma: A Clinicopathologic Study of a Rare Meningioma Subtype in 35 Patients. 61
32445901 2020
9
Pediatric clear cell meningioma involving the middle cranial fossa in the context of NF2 and SMARCE1 mutations. 61
32311644 2020
10
Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features. 61
30882396 2020
11
Pediatric nondura-based clear cell meningioma of the cauda equina: case report and review of literature. 61
29363346 2020
12
[The role of SMARCE1 in the diagnosis of clear cell meningioma]. 61
32187894 2020
13
Spinal Clear Cell Meningiomas: Clinical Features and Factors Predicting Recurrence. 61
31765868 2020
14
Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database. 61
33552966 2020
15
Clinical features and surgical outcomes of spinal clear cell meningioma: An institutional experience. 61
31416737 2019
16
[Persistent chest pain for 4 months and progressive lower limb weakness for 2 months in a boy]. 61
31416509 2019
17
Resection of a Dumbbell Skull Base Meningioma by a Combined Two-Staged Retrosigmoid and Transzygomatic Transcavernous Approach. 61
31143600 2019
18
Meningiomas with Collagenous Rosettes: A Report of Three Cases. 61
31143285 2019
19
Spinal Clear Cell Meningioma: Clinical Study with Long-Term Follow-Up in 12 Patients. 61
30342264 2019
20
Two novel cases of spinal clear cell meningioma with vertebra involvement. 61
30545721 2018
21
Intracranial clear cell meningioma: Clinical study with long-term follow-up in 24 patients. 61
30384120 2018
22
Prognostic Factors, Survival, and Treatment for Intracranial World Health Organization Grade II Chordoid Meningiomas and Clear-Cell Meningiomas. 61
29859361 2018
23
Loss of SMARCE1 expression is a specific diagnostic marker of clear cell meningioma: a comprehensive immunophenotypical and molecular analysis. 61
28474749 2018
24
Molecular progression in unusual recurrent non-pediatric intracranial clear cell meningioma. 61
28680293 2017
25
Cisterna magna meningiomas without dural attachment: Report of two cases. 61
28279513 2017
26
SMARCE1 mutation screening in classification of clear cell meningiomas. 61
27891692 2017
27
Clear-cell meningioma: Intraoperative diagnosis by squash cytology: Case report and review of the literature. 61
28484556 2017
28
Pediatric intracranial clear cell meningioma: a clinicopathological study of seven cases and literature review. 61
27787647 2017
29
Intracranial Clear Cell Meningiomas: Study on Clinical Features and Predictors of Recurrence. 61
27744084 2017
30
Suprasellar Clear Cell Meningioma in an Infant. 61
27606120 2016
31
Osteolytic clear cell meningioma of the petrous bone occurring 36 years after posterior cranial fossa irradiation: Case report. 61
27375148 2016
32
Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution. 61
26573513 2016
33
A five year-old child with clear cell petro-clival meningioma: case report with clinical and histopathological long-term follow-up. 61
26077595 2015
34
SMARCE1 mutations in pediatric clear cell meningioma: case report. 61
26114992 2015
35
Expression and diagnostic implications of carbonic anhydrase IX in several tumours with predominantly clear cell morphology. 61
25431204 2015
36
Pediatric intracranial clear cell meningioma associated with a germline mutation of SMARCE1: a novel case. 61
25249420 2015
37
Intrasellar Clear Cell Meningioma Mimicking Invasive Pituitary Adenoma: A Case Report and Review of the Literature. 61
26617154 2015
38
Clear cell meningioma in a child: A case report and review of literature. 61
25767587 2015
39
Full endoscopic endonasal transclival approach: meningioma attached to the ventral surface of the brainstem. 61
24685579 2014
40
Clear cell meningioma: clinical features, CT, and MR imaging findings in 23 patients. 61
24625613 2014
41
Nondura-based clear cell meningioma of the cauda equina in an adult. 61
22437332 2013
42
A case of clear cell meningioma with tyrosine-rich crystals. 61
23248340 2013
43
An intracranial and intraspinal clear cell meningioma. 61
22727208 2013
44
Differential expression of extracellular matrix-related genes in rare variants of meningioma. 61
22995327 2013
45
Spinal clear cell meningioma in a 3-year-old: a case report. 61
25377168 2013
46
Intracranial clear cell meningioma in two children with blood relations: two case reports and literature review. 61
22814951 2012
47
[Multifocal clear cell meningioma in the sacral and lumbar spine. Case report and literature review]. 61
22944518 2012
48
Radiation-associated meningiomas in children: clinical, pathological, and cytogenetic characteristics with a critical review of the literature. 61
22900483 2012
49
The optimal timing for imaging brain tumours and other brain lesions with 18F-labelled fluoromethylcholine: a dynamic positron emission tomography study. 61
22842224 2012
50
Clear cell meningioma with histologically aggressive appearance and clinically aggressive behavior: a case report. 61
22082299 2012

Variations for Clear Cell Meningioma

Expression for Clear Cell Meningioma

Search GEO for disease gene expression data for Clear Cell Meningioma.

Pathways for Clear Cell Meningioma

Pathways related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.89 SYP S100B NF2 MKI67 GFAP
2
Show member pathways
11.37 S100B PGR GFAP
3 10.82 VIM SYP S100B GFAP

GO Terms for Clear Cell Meningioma

Cellular components related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.55 SYP S100B NF2 CHGA CD34
2 SWI/SNF complex GO:0016514 9.26 SMARCE1 SMARCB1
3 nBAF complex GO:0071565 8.96 SMARCE1 SMARCB1
4 npBAF complex GO:0071564 8.62 SMARCE1 SMARCB1

Biological processes related to Clear Cell Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament organization GO:0045109 9.4 VIM GFAP
2 nucleosome disassembly GO:0006337 9.37 SMARCE1 SMARCB1
3 astrocyte development GO:0014002 9.32 VIM GFAP
4 Bergmann glial cell differentiation GO:0060020 9.26 VIM GFAP
5 paracrine signaling GO:0038001 9.16 PGR CD34
6 positive regulation of histone H4 acetylation GO:0090240 8.96 SMARCB1 MUC1
7 intermediate filament-based process GO:0045103 8.62 VIM GFAP

Sources for Clear Cell Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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