MCID: CLR112
MIFTS: 29

Clear Cell Papillary Renal Cell Carcinoma

Categories: Cancer diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Clear Cell Papillary Renal Cell Carcinoma

MalaCards integrated aliases for Clear Cell Papillary Renal Cell Carcinoma:

Name: Clear Cell Papillary Renal Cell Carcinoma 60

Classifications:

Orphanet: 60  
Rare renal diseases


External Ids:

ICD10 via Orphanet 35 C64
Orphanet 60 ORPHA404511

Summaries for Clear Cell Papillary Renal Cell Carcinoma

MalaCards based summary : Clear Cell Papillary Renal Cell Carcinoma is related to renal cell carcinoma, nonpapillary and renal adenoma. An important gene associated with Clear Cell Papillary Renal Cell Carcinoma is MITF (Melanocyte Inducing Transcription Factor), and among its related pathways/superpathways are Glucose / Energy Metabolism and Mitophagy - animal. Affiliated tissues include kidney, breast and skin, and related phenotypes are immune system and integument

Related Diseases for Clear Cell Papillary Renal Cell Carcinoma

Diseases related to Clear Cell Papillary Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 renal cell carcinoma, nonpapillary 30.8 AMACR CA9 HNF1A KRT7 MITF MME
2 renal adenoma 30.6 AMACR KRT7
3 cystadenoma 30.2 KRT7 MME VHL
4 renal cell carcinoma, papillary, 1 29.6 AMACR CA9 CDC73 KRT7 MITF MME
5 clear cell renal cell carcinoma 28.7 CA9 HNF1A KRT7 MME PBRM1 TFE3
6 chromophil renal cell carcinoma 10.9
7 von hippel-lindau syndrome 10.4
8 papillary adenoma 10.3 AMACR KRT7
9 epithelial predominant wilms' tumor 10.3 AMACR KRT7
10 ovarian mucinous adenocarcinoma 10.3 AMACR KRT7
11 nephrogenic adenoma 10.3 AMACR KRT7
12 metanephric adenoma 10.3 AMACR KRT7
13 urethral diverticulum 10.3 AMACR KRT7
14 balloon cell malignant melanoma 10.3 KRT7 MME
15 cervical adenoma malignum 10.3 KRT7 MME
16 cervical mucinous adenocarcinoma 10.3 KRT7 MME
17 malignant leydig cell tumor 10.3 KRT7 MME
18 endolymphatic sac tumor 10.3 KRT7 VHL
19 bladder lymphoma 10.3 KRT7 MME
20 adenomyoma 10.3 KRT7 MME
21 prostatic acinar adenocarcinoma 10.3 AMACR KRT7
22 pancreatic serous cystadenoma 10.2 KRT7 VHL
23 breast adenomyoepithelioma 10.2 KRT7 MME
24 breast myoepithelial neoplasm 10.2 KRT7 MME
25 eccrine sweat gland neoplasm 10.2 KRT7 MME
26 infiltrative basal cell carcinoma 10.2 KRT7 MME
27 cystadenofibroma 10.2 KRT7 MME
28 renal pelvis carcinoma 10.2 CA9 KRT7
29 pancreatic mucinous cystadenoma 10.2 KRT7 MME
30 mixed cell type cancer 10.2 KRT7 MME
31 ovarian mucinous neoplasm 10.2 CA9 KRT7
32 renal oncocytoma 10.2 KRT7 MME
33 ileum cancer 10.1 KRT7 MME
34 spindle cell carcinoma 10.1 AMACR KRT7
35 kidney benign neoplasm 10.1 AMACR KRT7 MME
36 oncocytoma 10.1 AMACR KRT7 MME
37 ovarian brenner tumor 10.1 KRT7 MME
38 corneal dystrophy, posterior polymorphous, 3 10.1 HNF1A KRT7
39 clear cell adenocarcinoma 10.1 AMACR KRT7
40 retinal hemangioblastoma 10.1 CA9 VHL
41 tuberous sclerosis 1 10.1
42 end stage renal failure 10.1
43 tuberous sclerosis 10.1
44 cystic kidney disease 10.1
45 kidney disease 10.1
46 adenoma 10.1
47 hypoxia 10.1
48 nephrogenic adenofibroma 10.0 CA9 KRT7 MME
49 cell type benign neoplasm 10.0 CDC73 KRT7
50 chromophobe renal cell carcinoma 10.0 HNF1A KRT7 MME

Graphical network of the top 20 diseases related to Clear Cell Papillary Renal Cell Carcinoma:



Diseases related to Clear Cell Papillary Renal Cell Carcinoma

Symptoms & Phenotypes for Clear Cell Papillary Renal Cell Carcinoma

MGI Mouse Phenotypes related to Clear Cell Papillary Renal Cell Carcinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.8 CA9 CDC73 MITF MME PBRM1 TFE3
2 integument MP:0010771 9.63 CDC73 HNF1A MITF MME TFE3 VHL
3 liver/biliary system MP:0005370 9.43 AMACR CDC73 HNF1A MME PBRM1 VHL
4 mortality/aging MP:0010768 9.23 AMACR CA9 CDC73 HNF1A MITF PBRM1

Drugs & Therapeutics for Clear Cell Papillary Renal Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Clear Cell Papillary Renal Cell Carcinoma

Genetic Tests for Clear Cell Papillary Renal Cell Carcinoma

Anatomical Context for Clear Cell Papillary Renal Cell Carcinoma

MalaCards organs/tissues related to Clear Cell Papillary Renal Cell Carcinoma:

42
Kidney, Breast, Skin, Prostate

Publications for Clear Cell Papillary Renal Cell Carcinoma

Articles related to Clear Cell Papillary Renal Cell Carcinoma:

(show top 50) (show all 55)
# Title Authors Year
1
Clear Cell Papillary Renal Cell Carcinoma. ( 30672334 )
2019
2
A Case of Clear Cell Papillary Renal Cell Carcinoma With Prominent Glycogen-Containing Intranuclear Inclusions. ( 30813834 )
2019
3
Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. ( 30924768 )
2019
4
The Tumor Entity Denominated "clear cell-papillary renal cell carcinoma" According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome. ( 28695322 )
2018
5
Renal cell carcinoma with angioleiomyoma-like stroma and clear cell papillary renal cell carcinoma: exploring SDHB protein immunohistochemistry and the relationship to tuberous sclerosis complex. ( 29180251 )
2018
6
Clinical features and survival analysis of clear cell papillary renal cell carcinoma: A 10-year retrospective study from two institutions. ( 29963177 )
2018
7
Expression of vitamin D receptor in clear cell papillary renal cell carcinoma. ( 29966830 )
2018
8
Clear cell papillary renal cell carcinoma - An indolent subtype of renal tumor. ( 30037497 )
2018
9
Clear cell papillary renal cell carcinoma: A case report and review of the literature. ( 30596034 )
2018
10
Cytomorphology of clear cell papillary renal cell carcinoma. ( 27636377 )
2017
11
Validation of 34betaE12 immunoexpression in clear cell papillary renal cell carcinoma as a sensitive biomarker. ( 27923499 )
2017
12
Clear Cell Papillary Renal Cell Carcinoma: New Clinical and Imaging Characteristics. ( 28130179 )
2017
13
Cystic clear cell papillary renal cell carcinoma: is it related to multilocular clear cell cystic neoplasm of low malignant potential? ( 26256827 )
2016
14
Incidence of Clear Cell Papillary Renal Cell Carcinoma in Low-Grade Renal Cell Carcinoma Cases: A 12-Year Retrospective Clinicopathologic Study From a Single Cancer Center. ( 26510859 )
2016
15
Renal Neoplasms With Overlapping Features of Clear Cell Renal Cell Carcinoma and Clear Cell Papillary Renal Cell Carcinoma: A Clinicopathologic Study of 37 Cases From a Single Institution. ( 26752401 )
2016
16
Clear cell papillary renal cell carcinoma as part of histologically discordant multifocal renal cell carcinoma: A case report and review of literature. ( 26857533 )
2016
17
Clear cell papillary renal cell carcinoma, renal angiomyoadenomatous tumor, and renal cell carcinoma with leiomyomatous stroma relationship of 3 types of renal tumors: a review. ( 26897641 )
2016
18
Genetic mutations in accordance with a low malignant potential tumour are not demonstrated in clear cell papillary renal cell carcinoma. ( 26941183 )
2016
19
Cytopathologic features of clear cell papillary renal cell carcinoma: A recently described variant to be considered in the differential diagnosis of clear cell renal epithelial neoplasms. ( 27062008 )
2016
20
What is the malignant potential of clear cell papillary renal cell carcinoma? ( 27364705 )
2016
21
Reply to Williamson S.R. What is the malignant potential of clear cell papillary renal cell carcinoma? Urol Oncol 2016; 34: 420. ( 27697387 )
2016
22
Xp11 translocation renal cell carcinoma morphologically mimicking clear cell-papillary renal cell carcinoma in an adult patient: report of a case expanding the morphologic spectrum of Xp11 translocation renal cell carcinomas. ( 25519951 )
2015
23
Clear cell papillary renal cell carcinoma: a potential mimic of conventional clear cell renal carcinoma on core biopsy. ( 25709850 )
2015
24
Clear cell-papillary renal cell carcinoma of the kidney not associated with end-stage renal disease: clinicopathologic correlation with expanded immunophenotypic and molecular characterization of a large cohort with emphasis on relationship with renal angiomyoadenomatous tumor. ( 25970682 )
2015
25
Clear cell papillary renal cell carcinoma and renal angiomyoadenomatous tumor: two variants of a morphologic, immunohistochemical, and genetic distinct entity of renal cell carcinoma. ( 25970683 )
2015
26
Clear cell papillary renal cell carcinoma: a clinicopathologic analysis of 6 cases. ( 26191150 )
2015
27
Quiz. Correct answer to the quiz. Check your diagnosis. Clear cell papillary renal cell carcinoma. ( 26328282 )
2015
28
Clear Cell Renal Cell Carcinoma With Borderline Features of Clear Cell Papillary Renal Cell Carcinoma: Combined Morphologic, Immunohistochemical, and Cytogenetic Analysis. ( 26457355 )
2015
29
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. ( 23887297 )
2014
30
Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes. ( 24155122 )
2014
31
Clear cell papillary renal cell carcinoma is the fourth most common histologic type of renal cell carcinoma in 290 consecutive nephrectomies for renal cell carcinoma. ( 24182559 )
2014
32
Clear cell papillary renal cell carcinoma is an indolent and low-grade neoplasm with overexpression of cyclin-D1. ( 24382138 )
2014
33
Papillary cystadenoma of the epididymis and broad ligament: morphologic and immunohistochemical overlap with clear cell papillary renal cell carcinoma. ( 24441657 )
2014
34
Clear cell papillary renal cell carcinoma: Incidence, morphological features, immunohistochemical profile, and biologic behavior: A single institution study. ( 24485757 )
2014
35
Clear cell papillary renal cell carcinoma: micro-RNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. ( 24703100 )
2014
36
Clear cell papillary renal cell carcinoma with angiomyomatous stroma: a histological, immunohistochemical, and fluorescence in situ hybridization study. ( 24771120 )
2014
37
Clear cell papillary renal cell carcinoma in patients with von Hippel-Lindau syndrome--clinicopathological features and comparative genomic analysis of 3 cases. ( 25081542 )
2014
38
Clear cell papillary renal cell carcinoma: a chromosomal microarray analysis of two cases using a novel Molecular Inversion Probe (MIP) technology. ( 25457185 )
2014
39
Clear cell papillary renal cell carcinoma: a review. ( 25550767 )
2014
40
Expression of parafibromin in clear cell papillary renal cell carcinoma. ( 23060304 )
2013
41
Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. ( 23238627 )
2013
42
Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. ( 23434146 )
2013
43
Clear cell papillary renal cell carcinoma-like tumors in patients with von Hippel-Lindau disease are unrelated to sporadic clear cell papillary renal cell carcinoma. ( 23648463 )
2013
44
Useful immunohistochemical panel for differentiating clear cell papillary renal cell carcinoma from its mimics. ( 23791764 )
2013
45
Clear cell papillary renal cell carcinoma: a clinicopathological study emphasizing ultrastructural features and cytogenetic heterogeneity. ( 24294381 )
2013
46
Renal-cell carcinomas in end-stage kidneys: a clinicopathological study with emphasis on clear-cell papillary renal-cell carcinoma and acquired cystic kidney disease-associated carcinoma. ( 21791489 )
2012
47
Clear cell papillary renal cell carcinoma with characteristic morphology and immunohistochemical staining pattern. ( 22931041 )
2012
48
Clear cell papillary renal cell carcinoma: a report of 15 cases including three cases of concurrent other-type renal cell carcinomas. ( 23323104 )
2012
49
Clear cell papillary renal cell carcinoma and clear cell renal cell carcinoma arising in acquired cystic disease of the kidney: an immunohistochemical and genetic study. ( 20952286 )
2011
50
Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. ( 21602815 )
2011

Variations for Clear Cell Papillary Renal Cell Carcinoma

Expression for Clear Cell Papillary Renal Cell Carcinoma

Search GEO for disease gene expression data for Clear Cell Papillary Renal Cell Carcinoma.

Pathways for Clear Cell Papillary Renal Cell Carcinoma

Pathways related to Clear Cell Papillary Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 AMACR CA9 HNF1A
2 10.77 MITF TFE3

GO Terms for Clear Cell Papillary Renal Cell Carcinoma

Biological processes related to Clear Cell Papillary Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.62 HNF1A MITF TFE3 VHL
2 humoral immune response GO:0006959 9.37 MITF TFE3
3 transcription by RNA polymerase II GO:0006366 9.26 CDC73 HNF1A
4 bile acid biosynthetic process GO:0006699 9.16 AMACR HNF1A
5 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 8.96 CA9 VHL
6 regulation of osteoclast differentiation GO:0045670 8.62 MITF TFE3

Molecular functions related to Clear Cell Papillary Renal Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein dimerization activity GO:0046983 8.8 HNF1A MITF TFE3

Sources for Clear Cell Papillary Renal Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
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74 UMLS
75 UMLS via Orphanet
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