MCID: CLF034
MIFTS: 16

Cleft Hard Palate

Categories: Fetal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Cleft Hard Palate

MalaCards integrated aliases for Cleft Hard Palate:

Name: Cleft Hard Palate 58 32
Cleft of Hard Palate 70

Classifications:

Orphanet: 58  
Developmental anomalies during embryogenesis


External Ids:

ICD10 via Orphanet 33 Q35.1
Orphanet 58 ORPHA101023
UMLS 70 C0432090

Summaries for Cleft Hard Palate

MalaCards based summary : Cleft Hard Palate, also known as cleft of hard palate, is related to cleft soft palate and cleft palate, isolated. An important gene associated with Cleft Hard Palate is GRHL3 (Grainyhead Like Transcription Factor 3). Related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Cleft Hard Palate

Diseases related to Cleft Hard Palate via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cleft soft palate 29.2 UBB GRHL3
2 cleft palate, isolated 10.7
3 cleft lip/palate 10.7
4 cleft lip with or without cleft palate 10.5
5 cleft lip 10.3
6 otitis media 10.0
7 sensorineural hearing loss 10.0
8 submucosal cleft palate 9.6 UBB GRHL3
9 uvula, bifid 9.6 UBB GRHL3

Graphical network of the top 20 diseases related to Cleft Hard Palate:



Diseases related to Cleft Hard Palate

Symptoms & Phenotypes for Cleft Hard Palate

GenomeRNAi Phenotypes related to Cleft Hard Palate according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.62 GRHL3 UBB

Drugs & Therapeutics for Cleft Hard Palate

Search Clinical Trials , NIH Clinical Center for Cleft Hard Palate

Genetic Tests for Cleft Hard Palate

Anatomical Context for Cleft Hard Palate

Publications for Cleft Hard Palate

Articles related to Cleft Hard Palate:

(show all 12)
# Title Authors PMID Year
1
Prospective evaluation of the effect of early nasal layer closure on definitive repair in cleft palate patients. 61
32471790 2020
2
A recessive lethal chondrodysplasia in a miniature zebu family results from an insertion affecting the chondroitin sulfat domain of aggrecan. 61
30305023 2018
3
Three-dimensional ultrasound demonstration of the fetal palate in high-risk patients: the accuracy of prenatal visualization. 61
23494892 2013
4
Free segmental vastus lateralis muscle flap for reconstruction of recalcitrant defects of the cleft hard palate. 61
22711197 2012
5
Validation of the Dutch registry of common oral clefts: quality of recording specific oral cleft features. 61
21091368 2012
6
Accuracy of prenatal three-dimensional ultrasound in the diagnosis of cleft hard palate when cleft lip is present. 61
21936003 2011
7
Repair of cleft lip and simultaneous repair of cleft hard palate with vomer flap in unilateral complete cleft lip and palate: a comparative study. 61
20842387 2010
8
Proximal chromosome 8q deletion in a boy with femoral bifurcation and other multiple congenital anomalies. 61
15103720 2004
9
[Simultaneous repair of cleft lip and closure of cleft hard palate with vomer flaps in patients with unilateral complete cleft lip and palate]. 61
12674618 2003
10
The effect on the ear of late closure of the cleft hard palate. 61
3697560 1986
11
[Treatment of cleft hard palate using lyophilized cartilage plate. Preliminary communication]. 61
4527128 1974
12
Present status of surgical treatment of cleft hard palate. 61
21002255 1946

Variations for Cleft Hard Palate

Expression for Cleft Hard Palate

Search GEO for disease gene expression data for Cleft Hard Palate.

Pathways for Cleft Hard Palate

GO Terms for Cleft Hard Palate

Biological processes related to Cleft Hard Palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.62 UBB GRHL3

Sources for Cleft Hard Palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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