Aliases & Classifications for Cleft Lip

MalaCards integrated aliases for Cleft Lip:

Name: Cleft Lip 12 77 56 45 15 17
Cleft Lip, Unilateral, Complete 12
Complete Unilateral Cleft Lip 12
Labium Leporinum 12
Cheiloschisis 12
Hare Lip 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9296
MeSH 45 D002971
NCIt 51 C87175
SNOMED-CT 69 62696001 80281008
ICD10 34 Q36 Q36.9

Summaries for Cleft Lip

MalaCards based summary : Cleft Lip, also known as cleft lip, unilateral, complete, is related to cleft lip and alveolus and isolated cleft lip. An important gene associated with Cleft Lip is PVT1 (Pvt1 Oncogene), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Dexmedetomidine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 77 Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft... more...

Related Diseases for Cleft Lip

Diseases related to Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 452)
# Related Disease Score Top Affiliating Genes
1 cleft lip and alveolus 34.0 IRF6 MSX1 NECTIN1 TP63
2 isolated cleft lip 33.8 IRF6 MSX1 NECTIN1 TBX10 TP63
3 cleft lip/palate 33.4 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
4 bartsocas-papas syndrome 32.2 IRF6 TP63
5 orofacial cleft 32.0 BMP4 IRF6 MSX1 NECTIN1 SUMO1 TP63
6 cleft palate, isolated 31.8 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
7 tooth size 30.7 BMP4 MSX1
8 tooth agenesis 30.1 BMP4 CDH1 FGFR1 IRF6 MSX1 SUMO1
9 split hand-foot malformation 30.0 FGFR1 SUMO1 TP63
10 cleft lip/palate-ectodermal dysplasia syndrome 12.7
11 ankyloblepharon-ectodermal defects-cleft lip/palate 12.7
12 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 12.7
13 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.6
14 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.6
15 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.5
16 brachial amelia, cleft lip, and holoprosencephaly 12.5
17 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.3
18 uveal coloboma-cleft lip and palate-intellectual disability 12.3
19 microbrachycephaly ptosis cleft lip 12.3
20 median cleft lip/mandibule 12.3
21 tibial hemimelia cleft lip palate 12.3
22 cleft lip/palate with abnormal thumbs and microcephaly 12.2
23 orofacial cleft 11 12.2
24 van der woude syndrome 1 12.2
25 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.2
26 cleft lip-retinopathy syndrome 12.2
27 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.2
28 radius, aplasia of, with cleft lip/palate 12.1
29 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.1
30 cleft lip and palate malrotation cardiopathy 12.1
31 cleft lip palate dysmorphism kumar type 12.1
32 cleft lip palate oligodontia syndactyly pili torti 12.1
33 cleft lip palate pituitary deficiency 12.1
34 cleft lip palate-tetraphocomelia 12.1
35 craniosynostosis cleft lip palate arthrogryposis 12.1
36 holoprosencephaly ectrodactyly cleft lip palate 12.1
37 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.1
38 cleft lip/palate-deafness-sacral lipoma syndrome 12.1
39 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.1
40 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 12.1
41 popliteal pterygium syndrome 12.1
42 orofacial cleft 5 12.1
43 orofacial cleft 8 12.1
44 zlotogora syndrome 12.1
45 orofacial cleft 10 12.1
46 blepharocheilodontic syndrome 1 12.1
47 branchiooculofacial syndrome 12.1
48 orofacial cleft 1 12.1
49 roberts syndrome 12.0
50 rapp-hodgkin syndrome 12.0

Graphical network of the top 20 diseases related to Cleft Lip:



Diseases related to Cleft Lip

Symptoms & Phenotypes for Cleft Lip

GenomeRNAi Phenotypes related to Cleft Lip according to GeneCards Suite gene sharing:

27 (show all 23)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.78 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.78 IRF6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.78 IRF6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.78 TFAP2A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.78 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.78 FGFR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.78 TFAP2A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.78 TFAP2A
9 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.78 TGFA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.78 FGFR1 IRF6 TFAP2A TGFA
11 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.78 IRF6
12 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.78 TFAP2A
13 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.78 FGFR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.78 TFAP2A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.78 TFAP2A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.78 FGFR1 IRF6 TFAP2A
17 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.78 FGFR1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.78 FGFR1 TFAP2A
19 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.78 IRF6
20 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.78 TFAP2A
21 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.78 FGFR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.78 FGFR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.78 TGFA

MGI Mouse Phenotypes related to Cleft Lip:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.34 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
2 craniofacial MP:0005382 10.31 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
3 digestive/alimentary MP:0005381 10.29 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MSX1
4 embryo MP:0005380 10.2 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
5 mortality/aging MP:0010768 10.13 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
6 integument MP:0010771 10.07 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
7 limbs/digits/tail MP:0005371 9.92 BMP4 FGFR1 IRF6 MSX1 TFAP2A TGFB3
8 normal MP:0002873 9.9 BMP4 CDH1 FGFR1 MID1 MSX1 SUMO1
9 hearing/vestibular/ear MP:0005377 9.88 BMP4 FGFR1 IRF6 MSX1 TBX10 TFAP2A
10 skeleton MP:0005390 9.65 BMP4 FGFR1 IRF6 MSX1 NECTIN1 TFAP2A
11 vision/eye MP:0005391 9.32 BMP4 FGFR1 MSX1 NECTIN1 TBX10 TFAP2A

Drugs & Therapeutics for Cleft Lip

Drugs for Cleft Lip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 94)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 113775-47-6 5311068 68602
2
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 38396-39-3, 2180-92-9 2474
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
6
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
10 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
11 Anti-Inflammatory Agents Phase 4
12 Adrenergic Agonists Phase 4,Phase 2
13 Hormones Phase 4
14 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
15 Anesthetics, Local Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
16 Hormone Antagonists Phase 4
17 Adrenergic alpha-Agonists Phase 4,Phase 2
18 Adrenergic Agents Phase 4,Phase 2
19 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
20 Gastrointestinal Agents Phase 4
21 Analgesics, Non-Narcotic Phase 4,Phase 2
22 glucocorticoids Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Hypnotics and Sedatives Phase 4,Phase 2
25 Anesthetics, General Phase 4,Phase 2,Phase 3,Not Applicable
26 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Not Applicable
27 HIV Protease Inhibitors Phase 4
28
protease inhibitors Phase 4
29 Autonomic Agents Phase 4
30 BB 1101 Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32 Antiemetics Phase 4
33 Platelet Aggregation Inhibitors Phase 4
34 Anesthetics, Inhalation Phase 4
35 Coagulants Phase 4
36 Fibrin Tissue Adhesive Phase 4
37 Hemostatics Phase 4
38
Acetylcholine Approved, Investigational Phase 3,Phase 1,Phase 2 51-84-3 187
39
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
40
leucovorin Approved Phase 3,Not Applicable 58-05-9 143 6006
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 59-30-3 6037
42 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
43 Botulinum Toxins Phase 3,Phase 1,Phase 2
44 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
45 Neuromuscular Agents Phase 3,Phase 1,Phase 2
46 Acetylcholine Release Inhibitors Phase 3,Phase 1,Phase 2
47 Cholinergic Agents Phase 3,Phase 1,Phase 2
48 Anesthetics, Dissociative Phase 2, Phase 3
49 Excitatory Amino Acid Antagonists Phase 2, Phase 3
50 Excitatory Amino Acids Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine as Adjuvant for Bupivacaine in Ultrasound Guided Infraorbital Nerve Block for Cleft Lip Repair Recruiting NCT03480607 Phase 4 Dexmedetomidine group;Dexamethasone group
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
3 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
4 Botulinum Toxin to Improve Results in Cleft Lip Repair Unknown status NCT01429402 Phase 3 Botulinum Toxin Type A;Botulinum Type A;Normal Saline;Normal Saline
5 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
6 Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
7 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
8 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
9 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
10 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
11 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
12 Suprazygomatic Block in Cleft Palate Surgery in Children Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
13 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
14 Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair Terminated NCT02958306 Phase 2
15 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489 Not Applicable
16 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726 Not Applicable
17 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
18 Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier Unknown status NCT02505360 Not Applicable
19 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
20 Evaluation of the Effect of Botulinum Toxin Type-A Injection Prior to Surgical Correction of Complete Unilateral Cleft Lip Repair by Modified Millard Cheiloplasty Unknown status NCT03047499 Botulinum toxin type A
21 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
22 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
23 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714 Not Applicable
24 Stentless Endoscopic Transnasal Transseptal Choanoplasty Unknown status NCT03167463 Not Applicable
25 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
26 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014 Not Applicable
27 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808
28 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
29 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
30 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
31 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
32 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
33 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
34 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
35 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
36 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
37 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
38 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
39 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
40 Periodontal Changes Following Mid Maxillary Distraction Completed NCT03686761 Not Applicable
41 A Study to Learn More About the Relationship Between the Development of a Gap in the Upper Lip (Cleft Lip) or in the Roof of the Mouth (Cleft Palate) in Newborns and the Use of Glucocorticoids by the Mother During Pregnancy: a Meta-analysis Completed NCT03788863 Diflucortolone valerate (BAY866146)
42 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
43 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
44 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
45 Effect of Alveolar Bone Grafting Completed NCT03549039
46 FaceBase Biorepository Completed NCT01252264
47 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
48 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
49 Alveolar Bone Graft Cortical Nasal Floor Completed NCT03883373
50 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205 Not Applicable

Search NIH Clinical Center for Cleft Lip

Cochrane evidence based reviews: cleft lip

Genetic Tests for Cleft Lip

Anatomical Context for Cleft Lip

MalaCards organs/tissues related to Cleft Lip:

42
Bone, Heart, Skin, Breast, Thyroid, Testes, Eye

Publications for Cleft Lip

Articles related to Cleft Lip:

(show top 50) (show all 5035)
# Title Authors Year
1
Performing Together: Monozygotic Twin Comedians/Twin research: Mirror-Image Cleft Lip and Palate; Dental Caries; Noninvasive Prenatal testing; Capgras Syndrome with Folie à Deux/In the News: Athletic Twins; Transgendered Twins; Crib-Sharing; Common Careers. ( 30739630 )
2019
2
Impacted maxillary canine in unilateral cleft lip and palate: A literature review. ( 30705572 )
2019
3
The Rare Association of Cleft Lip and/or Palate and Wilms Tumor. ( 30712371 )
2019
4
Dental management of a child with ectrodactyly ectodermal dysplasia cleft lip/palate syndrome: A case report. ( 30720215 )
2019
5
Prevalence of Hypodontia in Unilateral and Bilateral Cleft Lip and Palate Patients Inside and Outside Cleft Area: A Case-Control Study. ( 30730800 )
2019
6
Current methods for secondary alveolar bone grafting assessment in cleft lip and palate patients - A systematic review. ( 30733132 )
2019
7
Craniofacial morphology and soft tissue profile outcomes for complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30735011 )
2019
8
Impact of breastfeeding and/or bottle-feeding on surgical wound dehiscence after cleft lip repair in infants: A systematic review. ( 30737178 )
2019
9
Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis. ( 30740615 )
2019
10
Dental arch relationship outcomes for children with complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30742737 )
2019
11
Aesthetics Assessment and Patient Reported Outcome of Nasolabial Aesthetics in 18-Year-Old Patients With Unilateral Cleft Lip. ( 30808197 )
2019
12
The use of botulinum toxin type A to minimize scarring in cleft lip repair: A literature review. ( 30812070 )
2019
13
Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals. ( 30815431 )
2019
14
Reply: Outpatient versus Inpatient Primary Cleft Lip and Palate Surgery: Analysis of Early Complications. ( 30817672 )
2019
15
The Relationship between the Type of Cleft and Nasal Air Emission in Speech of Children with Cleft Palate or Cleft Lip and Palate. ( 30834000 )
2019
16
A Simple Technique to Repair a Residual Oronasal Fistula in Bilateral Cleft Lip and Palate Patients. ( 30836074 )
2019
17
Extension and validation of the protocol of orofacial myofunctional assessment for individuals with cleft lip and palate. ( 30843925 )
2019
18
Do Cleft Lip and Palate Types Affect Health-Related Quality of Life of Adolescents? ( 30845087 )
2019
19
Exploring the interaction between FGF genes and T-box genes among Chinese non-syndromic cleft lip with or without cleft palate case-parent trios. ( 30848863 )
2019
20
Social impact of cleft lip repair on married adults: an uncommon finding from a semi-urban African settlement. ( 30850222 )
2019
21
Breaking Symmetry: A Quantitative Analysis of Facial Skeleton Disharmony in Children Born with Bilateral Cleft Lip and Palate. ( 30851147 )
2019
22
Orthognathic Surgery for Patients with Cleft Lip and Palate. ( 30851748 )
2019
23
Cleft Palate with or without Cleft Lip: The Role of Retronasal Triangle View and Maxillary Gap at 11-14 Weeks. ( 30852571 )
2019
24
Intraoral Digital Impression Technique for a Neonate With Bilateral Cleft Lip and Palate. ( 30857398 )
2019
25
Influence of Severity on Aesthetic Outcomes of Unilateral Cleft Lip Repair in 1,823 Patients. ( 30859040 )
2019
26
Bone-anchored maxillary protraction in unilateral cleft lip and palate: a cephalometric appraisal. ( 30865780 )
2019
27
Three-Dimensional Assessment of Morphological Changes Following Nasoalveolar Molding Therapy in Cleft Lip and Palate Patients: A Case Report. ( 30866516 )
2019
28
A Pristine Approach for the Prominent Premaxilla in Bilateral Cleft Lip and Palate (BCLP) Cases. ( 30866673 )
2019
29
The absolute and relative effects of presurgical nasoalveolar moulding in bilateral cleft lip and palate patients compared with nasal growth in healthy newborns. ( 30878462 )
2019
30
MTHFR C677T polymorphism and risk of nonsyndromic cleft lip with or without cleft palate in the Moroccan population. ( 30881086 )
2019
31
3D 2-layer Elastic Models for Cleft Lip Rhinoplasty Made from 3D Camera. ( 30881815 )
2019
32
Effect on Facial Growth of the Management of Cleft Lip and Palate. ( 30882417 )
2019
33
Assessing the Fisher, Mohler, and Millard Techniques of Cleft Lip Repair Surgery With Eye-Tracking Technology. ( 30882421 )
2019
34
Association of single nucleotide polymorphisms in TPM1 rs11071720, rs3803499, rs12148828, and rs1972041 with the risk of nonsyndromic cleft lip with or without cleft palate in a sample of the Iranian population, a preliminary report. ( 30888054 )
2019
35
Tailored Microform Cleft Lip Repair: Personalizing Small Incisions, Orbicularis Reconstruction, and Rhinoplasty. ( 30889065 )
2019
36
Targeted next‑generation sequencing for research and diagnostics in congenital heart disease, and cleft lip and/or palate. ( 30896870 )
2019
37
The effect of a small triangular skin flap on vermillion height after cleft lip repair: a photogrammetry study. ( 30898431 )
2019
38
Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients. ( 30906959 )
2019
39
Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics. ( 30912603 )
2019
40
Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study. ( 30913937 )
2019
41
Symmetric Philtral Column Repair for Unilateral Cleft Lip. ( 30921134 )
2019
42
Discussion: Symmetric Philtral Column Repair for Unilateral Cleft Lip. ( 30921135 )
2019
43
The Smile Index: Part 2. A Simple, Prognostic Severity Scale for Unilateral Cleft Lip. ( 30921136 )
2019
44
Beware the Alar Base Optical Illusion in Assessment of Unilateral Cleft Lip Nasal Deformity. ( 30921137 )
2019
45
Unilateral cleft lip repair: A 'cut as you go' approach to the anatomical subunit approximation technique. ( 30922674 )
2019
46
Two novel genes TOX3 and COL21A1 in large extended Malay families with nonsyndromic cleft lip and/or palate. ( 30924295 )
2019
47
Surgical outcomes of 14 consecutive bilateral cleft lip patients treated with a modified version of the Millard and Manchester methods. ( 30934174 )
2019
48
Repair of a Secondary Cleft Lip Deformity With the Abbé Flap in a Pediatric Patient. ( 30935227 )
2019
49
Influence of vomer flap on craniofacial growth in patients with cleft lip and palate: A systematic review. ( 30935851 )
2019
50
Midface Growth in Patients With Unilateral Cleft Lip and Palate Treated With a Nasoalveolar Molding Protocol. ( 30950956 )
2019

Variations for Cleft Lip

Expression for Cleft Lip

Search GEO for disease gene expression data for Cleft Lip.

Pathways for Cleft Lip

Pathways related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 CDH1 FGFR1 TGFA TGFB3 WNT3
2 12.36 BMP4 CDH1 FGFR1 TGFA TGFB3 WNT3
3
Show member pathways
12.17 BMP4 CDH1 FGFR1 TGFA TGFB3
4
Show member pathways
11.93 BMP4 FGFR1 IRF6 TGFA TGFB3
5 11.86 BMP4 CDH1 TGFB3 WNT3
6
Show member pathways
11.81 BMP4 CDH1 FGFR1 TGFA TGFB3
7 11.68 BMP4 IRF6 MSX1 TP63
8
Show member pathways
11.65 SUMO1 TFAP2A TGFA
9 11.62 FGFR1 TGFA TGFB3
10 11.53 BMP4 FGFR1 TGFA TGFB3
11 11.49 CDH1 FGFR1 NECTIN1
12 11.36 BMP4 CDH1 FGFR1 MSX1 TFAP2A
13
Show member pathways
10.89 SUMO1 TP63
14 10.83 BMP4 CDH1 FGFR1 TGFA TGFB3
15 9.92 ARHGAP29 IRF6 TFAP2A TGFB3 TP63

GO Terms for Cleft Lip

Cellular components related to Cleft Lip according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 8.62 CDH1 NECTIN1

Biological processes related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.98 BMP4 FGFR1 MSX1 SUMO1 TFAP2A TP63
2 negative regulation of cell proliferation GO:0008285 9.96 BMP4 IRF6 MSX1 TFAP2A TGFB3
3 negative regulation of apoptotic process GO:0043066 9.92 BMP4 MSX1 TFAP2A TGFA
4 positive regulation of transcription, DNA-templated GO:0045893 9.87 BMP4 CDH1 IRF6 PHF8 TFAP2A TGFB3
5 cell development GO:0048468 9.72 BMP4 IRF6 TGFB3
6 odontogenesis of dentin-containing tooth GO:0042475 9.71 BMP4 MSX1 TP63
7 regulation of cell differentiation GO:0045595 9.69 BMP4 FGFR1 TFAP2A
8 odontogenesis GO:0042476 9.65 BMP4 MSX1 TGFB3
9 camera-type eye morphogenesis GO:0048593 9.64 BMP4 NECTIN1
10 middle ear morphogenesis GO:0042474 9.63 FGFR1 MSX1
11 positive regulation of bone mineralization GO:0030501 9.63 BMP4 TFAP2A TGFB3
12 anterior/posterior axis specification GO:0009948 9.61 BMP4 WNT3
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.6 BMP4 MSX1
14 positive regulation of SMAD protein signal transduction GO:0060391 9.59 BMP4 TGFB3
15 organ induction GO:0001759 9.58 BMP4 FGFR1
16 salivary gland morphogenesis GO:0007435 9.58 FGFR1 TGFB3
17 pituitary gland development GO:0021983 9.58 BMP4 CDH1 MSX1
18 mammary gland epithelium development GO:0061180 9.57 MSX1 WNT3
19 roof of mouth development GO:0060021 9.56 MSX1 SUMO1 TFAP2A VAX1
20 anatomical structure formation involved in morphogenesis GO:0048646 9.54 BMP4 TP63 WNT3
21 BMP signaling pathway involved in heart development GO:0061312 9.52 BMP4 MSX1
22 cloacal septation GO:0060197 9.49 BMP4 TP63
23 embryonic limb morphogenesis GO:0030326 9.46 BMP4 FGFR1 MSX1 TP63
24 embryonic forelimb morphogenesis GO:0035115 9.26 MSX1 TFAP2A TP63 WNT3
25 embryonic hindlimb morphogenesis GO:0035116 8.92 BMP4 MSX1 TP63 WNT3
26 regulation of transcription, DNA-templated GO:0006355 10.18 IRF6 MSX1 SUMO1 TBX10 TFAP2A TP63
27 cell differentiation GO:0030154 10.02 BMP4 CLPTM1 IRF6 TP63 VAX1
28 negative regulation of transcription, DNA-templated GO:0045892 10 BMP4 MSX1 SUMO1 TFAP2A TP63

Molecular functions related to Cleft Lip according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.43 CDH1 FGFR1 MID1 NECTIN1 TGFB3 TP63
2 sequence-specific DNA binding GO:0043565 9.02 IRF6 MSX1 TFAP2A TP63 VAX1

Sources for Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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