Aliases & Classifications for Cleft Lip

MalaCards integrated aliases for Cleft Lip:

Name: Cleft Lip 12 76 55 44 15
Cleft Lip, Unilateral, Complete 12
Complete Unilateral Cleft Lip 12
Labium Leporinum 12
Cheiloschisis 12
Hare Lip 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9296
ICD10 33 Q36 Q36.9
MeSH 44 D002971
NCIt 50 C87175
SNOMED-CT 68 62696001 80281008

Summaries for Cleft Lip

MalaCards based summary : Cleft Lip, also known as cleft lip, unilateral, complete, is related to cleft lip and alveolus and isolated cleft lip. An important gene associated with Cleft Lip is PVT1 (Pvt1 Oncogene), and among its related pathways/superpathways are Gastric cancer and Pathways in cancer. The drugs Bupivacaine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and heart, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Cleft lip and cleft palate, also known as orofacial cleft, is a group of conditions that includes cleft... more...

Related Diseases for Cleft Lip

Diseases related to Cleft Lip via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 390)
# Related Disease Score Top Affiliating Genes
1 cleft lip and alveolus 33.8 IRF6 MSX1 NECTIN1 TP63
2 isolated cleft lip 33.7 IRF6 MSX1 NECTIN1 TBX10 TP63
3 cleft lip/palate 33.6 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
4 cleft palate, isolated 32.1 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
5 bartsocas-papas syndrome 31.9 IRF6 TP63
6 tooth size 30.6 BMP4 MSX1
7 orofacial cleft 30.3 ARHGAP29 BMP4 CLPTM1 CLPTM1L FGFR1 IRF6
8 tooth agenesis 30.0 BMP4 CDH1 FGFR1 IRF6 MSX1 SUMO1
9 cleft lip/palate-ectodermal dysplasia syndrome 12.7
10 ankyloblepharon-ectodermal defects-cleft lip/palate 12.6
11 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 12.6
12 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.5
13 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.5
14 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.5
15 brachial amelia, cleft lip, and holoprosencephaly 12.4
16 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.3
17 uveal coloboma-cleft lip and palate-intellectual disability 12.3
18 microbrachycephaly ptosis cleft lip 12.3
19 median cleft lip/mandibule 12.2
20 tibial hemimelia cleft lip palate 12.2
21 van der woude syndrome 1 12.2
22 cleft lip/palate with abnormal thumbs and microcephaly 12.2
23 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.2
24 cleft lip-retinopathy syndrome 12.2
25 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.1
26 radius, aplasia of, with cleft lip/palate 12.1
27 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.1
28 cleft lip and palate malrotation cardiopathy 12.1
29 cleft lip palate dysmorphism kumar type 12.1
30 cleft lip palate oligodontia syndactyly pili torti 12.1
31 cleft lip palate pituitary deficiency 12.1
32 cleft lip palate-tetraphocomelia 12.1
33 craniosynostosis cleft lip palate arthrogryposis 12.1
34 holoprosencephaly ectrodactyly cleft lip palate 12.1
35 lagophthalmia cleft lip palate 12.1
36 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.1
37 cleft lip/palate-deafness-sacral lipoma syndrome 12.1
38 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.1
39 auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome 12.1
40 popliteal pterygium syndrome 12.1
41 zlotogora syndrome 12.1
42 blepharocheilodontic syndrome 1 12.1
43 branchiooculofacial syndrome 12.0
44 rapp-hodgkin syndrome 12.0
45 roberts syndrome 12.0
46 orofacial cleft 11 12.0
47 hartsfield syndrome 11.9
48 orofaciodigital syndrome vi 11.9
49 richieri-costa/guion-almeida syndrome 11.9
50 cleft, median, of upper lip with polyps of facial skin and nasal mucosa 11.9

Graphical network of the top 20 diseases related to Cleft Lip:



Diseases related to Cleft Lip

Symptoms & Phenotypes for Cleft Lip

GenomeRNAi Phenotypes related to Cleft Lip according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.77 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.77 IRF6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.77 IRF6
4 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.77 FGFR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.77 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-140 9.77 TFAP2A
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.77 TFAP2A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.77 TGFA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.77 FGFR1 IRF6 TFAP2A TGFA
10 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.77 IRF6
11 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.77 TFAP2A
12 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.77 FGFR1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.77 TFAP2A
14 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.77 TFAP2A
15 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.77 FGFR1 IRF6 TFAP2A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.77 FGFR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.77 FGFR1 TFAP2A
18 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.77 IRF6
19 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.77 TFAP2A
20 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.77 FGFR1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.77 FGFR1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.77 TGFA

MGI Mouse Phenotypes related to Cleft Lip:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.34 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
2 craniofacial MP:0005382 10.31 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
3 digestive/alimentary MP:0005381 10.29 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MSX1
4 embryo MP:0005380 10.2 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
5 mortality/aging MP:0010768 10.13 ARHGAP29 BMP4 CDH1 FGFR1 IRF6 MID1
6 integument MP:0010771 10.07 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
7 limbs/digits/tail MP:0005371 9.92 BMP4 FGFR1 IRF6 MSX1 TFAP2A TGFB3
8 normal MP:0002873 9.9 BMP4 CDH1 FGFR1 MID1 MSX1 SUMO1
9 hearing/vestibular/ear MP:0005377 9.88 BMP4 FGFR1 IRF6 MSX1 TBX10 TFAP2A
10 skeleton MP:0005390 9.65 BMP4 FGFR1 IRF6 MSX1 NECTIN1 TFAP2A
11 vision/eye MP:0005391 9.32 BMP4 FGFR1 MSX1 NECTIN1 TBX10 TFAP2A

Drugs & Therapeutics for Cleft Lip

Drugs for Cleft Lip (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
2
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 113775-47-6 68602 5311068
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
9 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
10 Analgesics Phase 4,Phase 2,Phase 3,Not Applicable
11 Adrenergic Agonists Phase 4,Phase 2
12 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1
13 Adrenergic alpha-Agonists Phase 4,Phase 2
14 Gastrointestinal Agents Phase 4
15 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 2
16 Anti-Inflammatory Agents Phase 4
17 Analgesics, Non-Narcotic Phase 4,Phase 2
18 Anesthetics, Local Phase 4,Phase 2,Phase 3,Early Phase 1
19 Adrenergic Agents Phase 4,Phase 2
20 Hypnotics and Sedatives Phase 4,Phase 2
21 Anesthetics, Intravenous Phase 4,Phase 2,Phase 3,Not Applicable
22 Anesthetics, General Phase 4,Phase 2,Phase 3,Not Applicable
23 Antineoplastic Agents, Hormonal Phase 4
24
protease inhibitors Phase 4
25 HIV Protease Inhibitors Phase 4
26 glucocorticoids Phase 4
27 Hormone Antagonists Phase 4
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
29 BB 1101 Phase 4
30 Autonomic Agents Phase 4
31 Antiemetics Phase 4
32 Hormones Phase 4
33 Anesthetics, Inhalation Phase 4
34 Platelet Aggregation Inhibitors Phase 4
35 Coagulants Phase 4
36 Fibrin Tissue Adhesive Phase 4
37 Hemostatics Phase 4
38
Acetylcholine Approved Phase 3,Phase 1,Phase 2 51-84-3 187
39
Ketamine Approved, Vet_approved Phase 2, Phase 3 6740-88-1 3821
40
leucovorin Approved Phase 3,Not Applicable 58-05-9 6006 143
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Not Applicable 59-30-3 6037
42 Cholinergic Agents Phase 3,Phase 1,Phase 2
43 abobotulinumtoxinA Phase 3,Phase 1,Phase 2
44 Neuromuscular Agents Phase 3,Phase 1,Phase 2
45 Acetylcholine Release Inhibitors Phase 3,Phase 1,Phase 2
46 Botulinum Toxins, Type A Phase 3,Phase 1,Phase 2
47 onabotulinumtoxinA Phase 3,Phase 1,Phase 2
48 Botulinum Toxins Phase 3,Phase 1,Phase 2
49 Anesthetics, Dissociative Phase 2, Phase 3
50 Excitatory Amino Acids Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 83)
# Name Status NCT ID Phase Drugs
1 Dexmedetomidine as Adjuvant for Bupivacaine in Ultrasound Guided Infraorbital Nerve Block for Cleft Lip Repair Recruiting NCT03480607 Phase 4 Dexmedetomidine group;Dexamethasone group
2 Does Sevoflurane Cause Genomic Damage Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
3 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
4 Botulinum Toxin to Improve Results in Cleft Lip Repair Unknown status NCT01429402 Phase 3 Botulinum Toxin Type A;Botulinum Type A;Normal Saline;Normal Saline
5 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
6 Infra-orbital Nerve Block for Post Operative Analgesia in Children Undergoing Cleft Lip Surgery. Completed NCT02514980 Phase 2, Phase 3 Bupivacaine;Ketamine
7 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
8 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
9 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
10 Effect of Platelet Rich Plasma (PRP) on the Esthetic Outcome and Scar Formation of Unilateral Cleft Lip Repair Unknown status NCT02958306 Phase 2
11 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
12 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
13 Suprazygomatic Block in Cleft Palate Surgery in Children Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
14 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
15 Comparison of Two Nasoalveolar Molding Techniques in Complete Unilateral Cleft Lip Patient Unknown status NCT01883726 Not Applicable
16 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
17 Biochemical and Histological Comparison of Nasal and Auricular Cartilage in the Fetus and Newborn With Cleft Lip Carrier Unknown status NCT02505360 Not Applicable
18 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
19 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
20 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
21 3D Imaging of Hard and Soft Tissue in Orthognathic Surgery Unknown status NCT00285714 Not Applicable
22 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
23 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014 Not Applicable
24 Susceptibility Genes in Autism Spectrum Disorders Unknown status NCT02628808
25 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
26 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
27 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
28 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
29 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
30 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
31 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
32 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
33 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
34 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
35 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
36 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
37 Periodontal Changes Following Mid Maxillary Distraction Completed NCT03686761 Not Applicable
38 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
39 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
40 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
41 FaceBase Biorepository Completed NCT01252264
42 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
43 Genetic Analysis of Fraser Syndrome and Fryns Syndrome Completed NCT00032877
44 Child's Adipose Cells: Capacity of Tissue Regeneration Completed NCT02779205 Not Applicable
45 Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population Completed NCT00341068
46 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
47 Organization of Teratology Information Services (OTIS) Autoimmune Diseases in Pregnancy Project Completed NCT00116272 Etanercept
48 Sleep and Behavior in Children With Cleft Palate Completed NCT01046591
49 Child and Infant Learning Project Completed NCT00077831
50 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787

Search NIH Clinical Center for Cleft Lip

Cochrane evidence based reviews: cleft lip

Genetic Tests for Cleft Lip

Anatomical Context for Cleft Lip

MalaCards organs/tissues related to Cleft Lip:

41
Bone, Skin, Heart, Breast, Kidney, Pituitary, Thyroid

Publications for Cleft Lip

Articles related to Cleft Lip:

(show top 50) (show all 2819)
# Title Authors Year
1
Child development skills and language in toddlers with cleft lip and palate. ( 30554694 )
2019
2
Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind, randomised study. ( 30308523 )
2019
3
The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients. ( 29619373 )
2018
4
Fascial Graft Repair of Wide Bilateral Cleft Lip Deformity. ( 29023290 )
2018
5
Rethinking isolated cleft lip and palate as a syndrome. ( 29500156 )
2018
6
Identification of key genes in cleft lip with or without cleft palate regulated by miR-199a-5p. ( 29958595 )
2018
7
To Admit or Not to Admit: That is the Cleft Lip Question. Confirming the Safety of Outpatient Cleft Lip Repair. ( 29952897 )
2018
8
Correcting the Cleft Lip Nose Deformity: The Graft Number 1 for the Columella. ( 29944554 )
2018
9
Biomechanical simulation of correcting primary unilateral cleft lip nasal deformity. ( 29953512 )
2018
10
Effects of Nasoalveolar Molding Therapy on Alveolar and Palatal Cleft Deformities in Unilateral and Bilateral Cleft Lip and Palate. ( 29381641 )
2018
11
Evaluation of alveolar bone support around incisors in patients with unilateral cleft lip, alveolus, and palate in late mixed dentition using cone beam computed tomography. ( 29384701 )
2018
12
Internationally adopted children with cleft lip and/or cleft palate: Middle ear findings and hearing during childhood. ( 29958613 )
2018
13
A Genome-Wide Search for Gene-Environment Effects in Isolated Cleft Lip with or without Cleft Palate Triads Points to an Interaction between Maternal Periconceptional Vitamin Use and Variants in <i>ESRRG</i>. ( 29535761 )
2018
14
Cleft Lip and Palate in CHARGE Syndrome: Phenotypic Features That Influence Management. ( 29437513 )
2018
15
The Impact of Maxillary Advancement on Consonant Proficiency in Patients With Cleft Lip and Palate, Lay Listeners' Opinion, and Patients' Satisfaction With Speech. ( 29949386 )
2018
16
A case of cleft lip and palate with severe maxillary retrognathism treated by distraction osteogenesis and custom made intraoral rapid maxillary expansion appliance: A 2-year follow-up of retention. ( 29937663 )
2018
17
Acoustic analysis of misarticulated trills in cleft lip and palate children. ( 29960457 )
2018
18
Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach. ( 29652537 )
2018
19
Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. ( 29388416 )
2018
20
Long-Term Skeletal Changes After Maxillary Distraction Osteogenesis in Growing Children With Cleft Lip/Palate. ( 29461366 )
2018
21
Autologous Fat Grafting in the Treatment of Cleft Lip Volume Asymmetry. ( 29401128 )
2018
22
3D Assessment of Nasolabial Appearance in Patients With Complete Unilateral Cleft Lip and Palate. ( 29351025 )
2018
23
The use of throat packs in pediatric cleft lip/palate surgery: a retrospective study. ( 29473105 )
2018
24
Rare Variant of Ankyloblepharon-ectodermal Defect-cleft Lip/Cleft Palate Syndrome: Curly Hair-ankyloblepharon-nail Disease Syndrome. ( 29440852 )
2018
25
A Case of Ankyloblepharon-ectodermal Defects-cleft Lip/palate-syndrome with Choanal Atresia and Skin Erosions: Phenotypic Variability of TP63-related Disorders. ( 29956718 )
2018
26
Receptive and expressive language characteristics of school-aged children with non-syndromic cleft lip and/or palate. ( 29968398 )
2018
27
Bone-anchored maxillary protraction in a patient with complete cleft lip and palate: A case report. ( 29407507 )
2018
28
Tooth-borne distraction osteogenesis versus conventional Le Fort I in maxillary advancement of cleft lip and palate patients. ( 29388417 )
2018
29
BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate. ( 29921024 )
2018
30
Novel <i>TBX22</i> mutations in Chinese nonsyndromic cleft lip/palate families. ( 29932061 )
2018
31
Influence of involuntary facial expressions on reproducibility of 3D stereophotogrammetry in children with and without complete unilateral cleft lip and palate from 3 to 18A months of age. ( 29943366 )
2018
32
Comprehensive Genetic Screening Recommended for Nonsyndromic Cleft Lip/Palate: Even in the absence of any signs of a syndrome, patients with cleft lip/palate may still carry a mutation in a gene linked to a syndrome and should receive comprehensive genetic testing. ( 29878711 )
2018
33
PVR/CD155 Ala67Thr Mutation and Cleft Lip/Palate. ( 29381645 )
2018
34
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P). ( 29371764 )
2018
35
Association of WNT Pathway Genes With Nonsyndromic Cleft Lip With or Without Cleft Palate. ( 29437498 )
2018
36
Association of CDKAL1 nucleotide variants with the risk of non-syndromic cleft lip with or without cleft palate. ( 29403086 )
2018
37
Longitudinal Study of Scar Hyperplasia Formation Following Cleft Lip Wound Healing. ( 29381621 )
2018
38
Single-Stage Primary Cleft Lip and Palate Repair: A Review of the Literature. ( 29944528 )
2018
39
A Comparative Evaluation of Efficacy and Efficiency of Grayson's Presurgical Nasoalveolar Molding Technique in Patients with Complete Unilateral Cleft Lip and Palate with Those Treated with Figueroa's Modified Technique. ( 29962760 )
2018
40
Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. ( 28967531 )
2018
41
3D-Printed Models of Cleft Lip and Palate for Surgical Training and Patient Education. ( 29437509 )
2018
42
Sleep frequently asked questions: Question 1: What abnormalities do babies with cleft lip and/or palate have on polysomnography? ( 29937141 )
2018
43
A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. ( 29524576 )
2018
44
Effectiveness of presurgical nasoalveolar molding therapy on unilateral cleft lip nasal deformity. ( 29436566 )
2018
45
Open Rhinoplasty Using Concealing Incisions for Mild Bifid Nose With Unilateral Mini-Microform Cleft Lip. ( 29543682 )
2018
46
Evaluation of Airway Volume in Cleft Lip and Palate Following Nasoalveolar Molding. ( 29944553 )
2018
47
Minimally invasive versus standard approach in LeFort 1 osteotomy in patients with history of cleft lip and palate. ( 29408322 )
2018
48
Three-dimensional radiological evaluation of secondary alveolar bone grafting in cleft lip and palate patients: a systematic review. ( 29947253 )
2018
49
A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. ( 29173718 )
2018
50
Effectiveness of Nasoalveolar Molding in the Unilateral Cleft Lip and Cleft Palate. ( 29944571 )
2018

Variations for Cleft Lip

Expression for Cleft Lip

Search GEO for disease gene expression data for Cleft Lip.

Pathways for Cleft Lip

Pathways related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 CDH1 FGFR1 TGFA TGFB3 WNT3
2 12.35 BMP4 CDH1 FGFR1 TGFA TGFB3 WNT3
3
Show member pathways
12.17 BMP4 CDH1 FGFR1 TGFA TGFB3
4
Show member pathways
11.93 BMP4 FGFR1 IRF6 TGFA TGFB3
5 11.86 BMP4 CDH1 TGFB3 WNT3
6
Show member pathways
11.81 BMP4 CDH1 FGFR1 TGFA TGFB3
7 11.68 BMP4 IRF6 MSX1 TP63
8
Show member pathways
11.65 SUMO1 TFAP2A TGFA
9 11.62 FGFR1 TGFA TGFB3
10 11.53 BMP4 FGFR1 TGFA TGFB3
11 11.49 CDH1 FGFR1 NECTIN1
12 11.36 BMP4 CDH1 FGFR1 MSX1 TFAP2A
13
Show member pathways
10.89 SUMO1 TP63
14 10.83 BMP4 CDH1 FGFR1 TGFA TGFB3
15 9.92 ARHGAP29 IRF6 TFAP2A TGFB3 TP63

GO Terms for Cleft Lip

Cellular components related to Cleft Lip according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 8.62 CDH1 NECTIN1

Biological processes related to Cleft Lip according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.96 BMP4 IRF6 MSX1 TFAP2A TGFB3
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 BMP4 FGFR1 MSX1 SUMO1 TFAP2A TP63
3 positive regulation of transcription, DNA-templated GO:0045893 9.87 BMP4 CDH1 IRF6 PHF8 TFAP2A TGFB3
4 cell development GO:0048468 9.72 BMP4 IRF6 TGFB3
5 odontogenesis of dentin-containing tooth GO:0042475 9.71 BMP4 MSX1 TP63
6 regulation of cell differentiation GO:0045595 9.69 BMP4 FGFR1 TFAP2A
7 odontogenesis GO:0042476 9.65 BMP4 MSX1 TGFB3
8 camera-type eye morphogenesis GO:0048593 9.64 BMP4 NECTIN1
9 middle ear morphogenesis GO:0042474 9.63 FGFR1 MSX1
10 positive regulation of bone mineralization GO:0030501 9.63 BMP4 TFAP2A TGFB3
11 anterior/posterior axis specification GO:0009948 9.61 BMP4 WNT3
12 pituitary gland development GO:0021983 9.61 BMP4 CDH1 MSX1
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.6 BMP4 MSX1
14 positive regulation of SMAD protein signal transduction GO:0060391 9.59 BMP4 TGFB3
15 organ induction GO:0001759 9.58 BMP4 FGFR1
16 salivary gland morphogenesis GO:0007435 9.58 FGFR1 TGFB3
17 mammary gland epithelium development GO:0061180 9.57 MSX1 WNT3
18 roof of mouth development GO:0060021 9.56 MSX1 SUMO1 TFAP2A VAX1
19 anatomical structure formation involved in morphogenesis GO:0048646 9.54 BMP4 TP63 WNT3
20 BMP signaling pathway involved in heart development GO:0061312 9.52 BMP4 MSX1
21 cloacal septation GO:0060197 9.49 BMP4 TP63
22 embryonic limb morphogenesis GO:0030326 9.46 BMP4 FGFR1 MSX1 TP63
23 embryonic forelimb morphogenesis GO:0035115 9.26 MSX1 TFAP2A TP63 WNT3
24 embryonic hindlimb morphogenesis GO:0035116 8.92 BMP4 MSX1 TP63 WNT3
25 regulation of transcription, DNA-templated GO:0006355 10.18 IRF6 MSX1 SUMO1 TBX10 TFAP2A TP63
26 cell differentiation GO:0030154 10.1 BMP4 CLPTM1 FGFR1 IRF6 TP63 VAX1
27 negative regulation of apoptotic process GO:0043066 10.02 BMP4 FGFR1 MSX1 TFAP2A TGFA
28 negative regulation of transcription, DNA-templated GO:0045892 10 BMP4 MSX1 SUMO1 TFAP2A TP63

Molecular functions related to Cleft Lip according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 CDH1 FGFR1 MID1 NECTIN1 TGFB3 TP63
2 sequence-specific DNA binding GO:0043565 9.35 IRF6 MSX1 TFAP2A TP63 VAX1
3 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.62 MSX1 TFAP2A

Sources for Cleft Lip

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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