MCID: CLF049
MIFTS: 25

Cleft Lip and Alveolus

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip and Alveolus

MalaCards integrated aliases for Cleft Lip and Alveolus:

Name: Cleft Lip and Alveolus 59

Classifications:



External Ids:

Orphanet 59 ORPHA141291
UMLS via Orphanet 74 C1298692
ICD10 via Orphanet 34 Q36.0 Q36.1 Q36.9

Summaries for Cleft Lip and Alveolus

MalaCards based summary : Cleft Lip and Alveolus is related to cleft lip and cleft lip/palate. An important gene associated with Cleft Lip and Alveolus is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hypothetical Craniofacial Development Pathway. Affiliated tissues include bone, and related phenotypes are craniofacial and growth/size/body region

Related Diseases for Cleft Lip and Alveolus

Graphical network of the top 20 diseases related to Cleft Lip and Alveolus:



Diseases related to Cleft Lip and Alveolus

Symptoms & Phenotypes for Cleft Lip and Alveolus

MGI Mouse Phenotypes related to Cleft Lip and Alveolus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.67 IRF6 MSX1 NECTIN1 TP63
2 growth/size/body region MP:0005378 9.56 IRF6 MSX1 NECTIN1 TP63
3 digestive/alimentary MP:0005381 9.5 IRF6 MSX1 TP63
4 integument MP:0010771 9.46 IRF6 MSX1 NECTIN1 TP63
5 limbs/digits/tail MP:0005371 9.13 IRF6 MSX1 TP63
6 skeleton MP:0005390 8.92 IRF6 MSX1 NECTIN1 TP63

Drugs & Therapeutics for Cleft Lip and Alveolus

Search Clinical Trials , NIH Clinical Center for Cleft Lip and Alveolus

Genetic Tests for Cleft Lip and Alveolus

Anatomical Context for Cleft Lip and Alveolus

MalaCards organs/tissues related to Cleft Lip and Alveolus:

41
Bone

Publications for Cleft Lip and Alveolus

Articles related to Cleft Lip and Alveolus:

(show all 21)
# Title Authors Year
1
Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach. ( 29652537 )
2018
2
Skoog Primary Periosteoplasty versus Secondary Alveolar Bone Grafting in Unilateral Cleft Lip and Alveolus: Long-Term Effects on Alveolar Bone Formation and Maxillary Growth. ( 28027239 )
2017
3
Replantation of a displaced incisor in a boy with a cleft lip and alveolus: a case report. ( 27633512 )
2016
4
Asymmetric Dental Development Investigated by Cone-Beam Computed Tomography in Patients With Unilateral Cleft Lip and Alveolus. ( 26274901 )
2016
5
Comparison of tooth development stage of the maxillary anterior teeth before and after secondary alveolar bone graft: Unilateral cleft lip and alveolus vs unilateral cleft lip and palate. ( 24731061 )
2014
6
Orthodontic treatment in Down's syndrome patient with unilateral cleft lip and alveolus. ( 25477037 )
2014
7
Maxillary growth after the use of protraction head gear in conjunction with presurgical orthopedics and gingivoperiosteoplasty for complete bilateral cleft lip and alveolus patients. ( 24036752 )
2013
8
Management of prominent premaxilla in bilateral cleft lip and alveolus. ( 23586364 )
2013
9
Orthodontic treatment of unilateral cleft lip and alveolus patient with maxillary lateral incisor missing: case report. ( 24386758 )
2013
10
Maxillary arch width in unoperated adult bilateral cleft lip and alveolus and complete bilateral cleft lip and palate. ( 20477967 )
2010
11
Maxillary arch width in unoperated adult of the unilateral cleft lip and alveolus patients. ( 23139511 )
2009
12
Orthodontic treatment of cleft lip and alveolus using secondary autogenous cancellous bone grafting: a case report. ( 19388435 )
2009
13
Maxillary segmental distraction in a patient with bilateral cleft lip and alveolus with subsequent tooth transplantation: a preliminary case report. ( 18616372 )
2008
14
Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patients. ( 17029545 )
2007
15
Excessive rapid palatal expansion with Latham appliance for distal repositioning of protruded premaxilla in bilateral cleft lip and alveolus. ( 17105324 )
2006
16
Prevalence of a Simonart's band in patients with complete cleft lip and alveolus and complete cleft lip and palate. ( 16854202 )
2006
17
Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate. ( 17169738 )
2006
18
Management of nasally erupting deciduous canine in operated cleft lip and alveolus patient. ( 16582530 )
2006
19
Intranasal tooth as a complication of cleft lip and alveolus in a four year old child: case report and literature review. ( 11484473 )
2001
20
Intranasal tooth in a patient with a cleft lip and alveolus. ( 8695624 )
1996
21
Intranasal tooth in a patient with cleft lip and alveolus. ( 9026060 )
1996

Variations for Cleft Lip and Alveolus

Expression for Cleft Lip and Alveolus

Search GEO for disease gene expression data for Cleft Lip and Alveolus.

Pathways for Cleft Lip and Alveolus

Pathways related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 IRF6 MSX1 TP63
2 9.86 IRF6 TP63

GO Terms for Cleft Lip and Alveolus

Biological processes related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.58 IRF6 MSX1 TP63
2 transcription by RNA polymerase II GO:0006366 9.54 IRF6 MSX1 TP63
3 keratinocyte differentiation GO:0030216 9.32 IRF6 TP63
4 odontogenesis of dentin-containing tooth GO:0042475 9.26 MSX1 TP63
5 embryonic limb morphogenesis GO:0030326 9.16 MSX1 TP63
6 embryonic forelimb morphogenesis GO:0035115 8.96 MSX1 TP63
7 embryonic hindlimb morphogenesis GO:0035116 8.62 MSX1 TP63

Molecular functions related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.26 IRF6 TP63
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.16 IRF6 MSX1
3 sequence-specific DNA binding GO:0043565 9.13 IRF6 MSX1 TP63
4 p53 binding GO:0002039 8.62 MSX1 TP63

Sources for Cleft Lip and Alveolus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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