MCID: CLF049
MIFTS: 25

Cleft Lip and Alveolus

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip and Alveolus

MalaCards integrated aliases for Cleft Lip and Alveolus:

Name: Cleft Lip and Alveolus 60

Classifications:



External Ids:

ICD10 via Orphanet 35 Q36.0 Q36.1 Q36.9
UMLS via Orphanet 75 C1298692
Orphanet 60 ORPHA141291

Summaries for Cleft Lip and Alveolus

MalaCards based summary : Cleft Lip and Alveolus is related to cleft lip and cleft lip/palate. An important gene associated with Cleft Lip and Alveolus is NECTIN1 (Nectin Cell Adhesion Molecule 1), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hypothetical Craniofacial Development Pathway. Affiliated tissues include bone, and related phenotypes are craniofacial and growth/size/body region

Related Diseases for Cleft Lip and Alveolus

Diseases related to Cleft Lip and Alveolus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 cleft lip 30.0 IRF6 MSX1 NECTIN1 TP63
2 cleft lip/palate 29.5 IRF6 MSX1 NECTIN1 TP63
3 syngnathia 9.9 IRF6 MSX1
4 chromosome 1q21.1 deletion syndrome, 1.35-mb 9.8 IRF6 TP63
5 physical disorder 9.7 IRF6 MSX1
6 cleft lip/palate-ectodermal dysplasia syndrome 9.7 NECTIN1 TP63
7 bartsocas-papas syndrome 9.7 IRF6 TP63
8 ectodermal dysplasia 9.7 NECTIN1 TP63
9 tooth agenesis 9.6 IRF6 MSX1
10 isolated cleft lip 9.1 IRF6 MSX1 NECTIN1 TP63
11 orofacial cleft 9.1 IRF6 MSX1 NECTIN1 TP63
12 cleft palate, isolated 9.1 IRF6 MSX1 NECTIN1 TP63

Graphical network of the top 20 diseases related to Cleft Lip and Alveolus:



Diseases related to Cleft Lip and Alveolus

Symptoms & Phenotypes for Cleft Lip and Alveolus

MGI Mouse Phenotypes related to Cleft Lip and Alveolus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.67 IRF6 MSX1 NECTIN1 TP63
2 growth/size/body region MP:0005378 9.56 IRF6 MSX1 NECTIN1 TP63
3 digestive/alimentary MP:0005381 9.5 IRF6 MSX1 TP63
4 integument MP:0010771 9.46 IRF6 MSX1 NECTIN1 TP63
5 limbs/digits/tail MP:0005371 9.13 IRF6 MSX1 TP63
6 skeleton MP:0005390 8.92 IRF6 MSX1 NECTIN1 TP63

Drugs & Therapeutics for Cleft Lip and Alveolus

Search Clinical Trials , NIH Clinical Center for Cleft Lip and Alveolus

Genetic Tests for Cleft Lip and Alveolus

Anatomical Context for Cleft Lip and Alveolus

MalaCards organs/tissues related to Cleft Lip and Alveolus:

42
Bone

Publications for Cleft Lip and Alveolus

Articles related to Cleft Lip and Alveolus:

(show all 22)
# Title Authors Year
1
Eighteen-Year Follow-Up of 160 Consecutive Individuals Born With Unilateral Cleft Lip or Cleft Lip and Alveolus Treated by the Oslo Cleft Lip and Palate Team. ( 30686058 )
2019
2
Subphenotyping and Classification of Cleft Lip and Alveolus in Adult Unoperated Patients: A New Embryological Approach. ( 29652537 )
2018
3
Skoog Primary Periosteoplasty versus Secondary Alveolar Bone Grafting in Unilateral Cleft Lip and Alveolus: Long-Term Effects on Alveolar Bone Formation and Maxillary Growth. ( 28027239 )
2017
4
Replantation of a displaced incisor in a boy with a cleft lip and alveolus: a case report. ( 27633512 )
2016
5
Asymmetric Dental Development Investigated by Cone-Beam Computed Tomography in Patients With Unilateral Cleft Lip and Alveolus. ( 26274901 )
2016
6
Orthodontic treatment in Down's syndrome patient with unilateral cleft lip and alveolus. ( 25477037 )
2014
7
Comparison of tooth development stage of the maxillary anterior teeth before and after secondary alveolar bone graft: Unilateral cleft lip and alveolus vs unilateral cleft lip and palate. ( 24731061 )
2014
8
Orthodontic treatment of unilateral cleft lip and alveolus patient with maxillary lateral incisor missing: case report. ( 24386758 )
2013
9
Maxillary growth after the use of protraction head gear in conjunction with presurgical orthopedics and gingivoperiosteoplasty for complete bilateral cleft lip and alveolus patients. ( 24036752 )
2013
10
Management of prominent premaxilla in bilateral cleft lip and alveolus. ( 23586364 )
2013
11
Maxillary arch width in unoperated adult bilateral cleft lip and alveolus and complete bilateral cleft lip and palate. ( 20477967 )
2010
12
Maxillary arch width in unoperated adult of the unilateral cleft lip and alveolus patients. ( 23139511 )
2009
13
Orthodontic treatment of cleft lip and alveolus using secondary autogenous cancellous bone grafting: a case report. ( 19388435 )
2009
14
Maxillary segmental distraction in a patient with bilateral cleft lip and alveolus with subsequent tooth transplantation: a preliminary case report. ( 18616372 )
2008
15
Congenital missing permanent teeth in Korean unilateral cleft lip and alveolus and unilateral cleft lip and palate patients. ( 17029545 )
2007
16
Management of nasally erupting deciduous canine in operated cleft lip and alveolus patient. ( 16582530 )
2006
17
Prevalence of a Simonart's band in patients with complete cleft lip and alveolus and complete cleft lip and palate. ( 16854202 )
2006
18
Excessive rapid palatal expansion with Latham appliance for distal repositioning of protruded premaxilla in bilateral cleft lip and alveolus. ( 17105324 )
2006
19
Cleft sidedness and congenitally missing or malformed permanent maxillary lateral incisors in Korean patients with unilateral cleft lip and alveolus or unilateral cleft lip and palate. ( 17169738 )
2006
20
Intranasal tooth as a complication of cleft lip and alveolus in a four year old child: case report and literature review. ( 11484473 )
2001
21
Intranasal tooth in a patient with a cleft lip and alveolus. ( 8695624 )
1996
22
Intranasal tooth in a patient with cleft lip and alveolus. ( 9026060 )
1996

Variations for Cleft Lip and Alveolus

Expression for Cleft Lip and Alveolus

Search GEO for disease gene expression data for Cleft Lip and Alveolus.

Pathways for Cleft Lip and Alveolus

Pathways related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 IRF6 MSX1 TP63
2 9.86 IRF6 TP63

GO Terms for Cleft Lip and Alveolus

Biological processes related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.54 IRF6 MSX1 TP63
2 keratinocyte differentiation GO:0030216 9.32 IRF6 TP63
3 odontogenesis of dentin-containing tooth GO:0042475 9.26 MSX1 TP63
4 embryonic limb morphogenesis GO:0030326 9.16 MSX1 TP63
5 embryonic forelimb morphogenesis GO:0035115 8.96 MSX1 TP63
6 embryonic hindlimb morphogenesis GO:0035116 8.62 MSX1 TP63

Molecular functions related to Cleft Lip and Alveolus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.26 IRF6 TP63
2 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.16 IRF6 MSX1
3 sequence-specific DNA binding GO:0043565 9.13 IRF6 MSX1 TP63
4 p53 binding GO:0002039 8.62 MSX1 TP63

Sources for Cleft Lip and Alveolus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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