Cleft Lip/palate disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MedlinePlus: ⁴¹ Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary: Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 7 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Signal Transduction and PAK Pathway. The drugs Rocuronium and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and tongue, and related phenotypes are abnormality of dental eruption and delayed speech and language development

Orphanet: ⁵⁸ Cleft lip and palate is a fissure type embryopathy extending across the upper lip, nasal base, alveolar ridge and the hard and soft palate.

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Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 724)

#	Related Disease	Score	Top Affiliating Genes
1	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1	33.1	TP63 NECTIN1 IRF6 EEC1
2	short-rib thoracic dysplasia 7 with or without polydactyly	32.2	WDR35 INTU
3	popliteal pterygium syndrome	32.0	NECTIN1 MSX1 IRF6 ARHGAP29
4	short-rib thoracic dysplasia 3 with or without polydactyly	32.0	WDR35 INTU CEP120
5	short-rib thoracic dysplasia 12	31.8	WDR35 INTU CEP120
6	van der woude syndrome	30.9	TP63 TGFA NECTIN1 MSX1 IRF6 BMP4
7	ectodermal dysplasia	30.6	TP63 NECTIN1 MSX1 EEC1 CDH1
8	isolated cleft lip	30.5	TP63 NECTIN1 MSX1 IRF6
9	cleft lip with or without cleft palate	30.3	TGFA NECTIN1 MSX1 CDH1 ARHGAP29
10	synostosis	30.1	MSX1 FGFR1 BMP4
11	cleft lip and alveolus	30.1	TP63 NECTIN1 MSX1 IRF6
12	blepharocheilodontic syndrome 1	30.0	DLX4 CDH1 ARHGAP29
13	cleft lip	29.8	TP63 TGFA NECTIN1 MSX1 MID1 IRF6
14	ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	29.7	TP63 NECTIN1 MSX1 BMP4
15	ankyloglossia with or without tooth anomalies	29.7	TP63 MSX1 MID1 IRF6
16	polydactyly	29.6	WDR35 MSX1 INTU CEP120
17	chromosome 2q35 duplication syndrome	29.6	WDR35 TP63 NECTIN1 MSX1 IRF6 FGFR1
18	lacrimoauriculodentodigital syndrome	29.6	MSX1 FGFR1 BMP4
19	coloboma of macula	29.6	YAP1 MSX1 FGFR1 BMP4
20	ectodermal dysplasia 1, hypohidrotic, x-linked	29.5	TP63 NECTIN1 MSX1 BMP4
21	cleft palate, isolated	29.5	TP63 TGFA PDGFRA NECTIN1 MSX1 MID1
22	osteochondrodysplasia	29.3	WDR35 MSX1 FGFR1 BMP4
23	craniosynostosis	29.0	WDR35 PDGFRA MSX1 FGFR1 BMP4
24	tooth agenesis	28.9	WDR35 TP63 TGFA NECTIN1 MSX1 IRF6
25	orofacial cleft	28.8	TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
26	ankyloblepharon-ectodermal defects-cleft lip/palate	12.0
27	cleft lip/palate-ectodermal dysplasia syndrome	11.9
28	hartsfield syndrome	11.9
29	ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3	11.8
30	arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay	11.8
31	uveal coloboma-cleft lip and palate-intellectual disability	11.8
32	cleft palate, cardiac defects, and mental retardation	11.8
33	juberg-hayward syndrome	11.8
34	coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	11.8
35	vici syndrome	11.7
36	rapp-hodgkin syndrome	11.7
37	orofaciodigital syndrome vi	11.7
38	acrofrontofacionasal dysostosis	11.7
39	cleft lip/palate-deafness-sacral lipoma syndrome	11.6
40	cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome	11.6
41	bustos simosa pinto cisternas syndrome	11.6
42	roberts-sc phocomelia syndrome	11.6
43	pilotto syndrome	11.6
44	ectrodactyly and ectodermal dysplasia without cleft lip/palate	11.6
45	fryns microphthalmia syndrome	11.5
46	microcephaly, corpus callosum dysgenesis, and cleft lip/palate	11.5
47	richieri-costa/guion-almeida syndrome	11.5
48	orofacial cleft 1	11.5
49	kapur-toriello syndrome	11.5
50	3mc syndrome	11.5

Graphical network of the top 20 diseases related to Cleft Lip/palate:

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Symptoms & Phenotypes for Cleft Lip/palate

Human phenotypes related to Cleft Lip/palate:

⁵⁸ ³⁰ (show all 21)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	abnormality of dental eruption ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0006292
2	delayed speech and language development ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000750
3	recurrent otitis media ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000403
4	poor suck ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002033
5	oral-pharyngeal dysphagia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0200136
6	velopharyngeal insufficiency ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000220
7	speech articulation difficulties ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0009088
8	unilateral cleft palate ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100334
9	dental malocclusion ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000689
10	conductive hearing impairment ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000405
11	nasal speech ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001611
12	malnutrition ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0004395
13	abnormal number of permanent teeth ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0011044
14	bilateral cleft palate ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100337
15	peg-shaped maxillary lateral incisors ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0006342
16	palate fistula ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0010294
17	agenesis of lateral incisor ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0200153
18	hypoplasia of the maxilla ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0000327
19	feeding difficulties in infancy ⁵⁸		Frequent (79-30%)
20	cleft palate ⁵⁸		Frequent (79-30%)
21	oral cleft ⁵⁸		Frequent (79-30%)

MGI Mouse Phenotypes related to Cleft Lip/palate:

⁴⁵ (show all 12)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.33	ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
2	embryo	MP:0005380	10.28	ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
3	muscle	MP:0005369	10.19	BMP4 DLG1 FGFR1 MID1 MSX1 PDGFRA
4	digestive/alimentary	MP:0005381	10.18	ARHGAP29 BMP4 CDH1 DLG1 FGFR1 IRF6
5	normal	MP:0002873	10.16	AMOTL1 BMP4 CDH1 FGFR1 INTU MID1
6	limbs/digits/tail	MP:0005371	10.13	BMP4 DLG1 FGFR1 INTU IRF6 MSX1
7	craniofacial	MP:0005382	10.11	AMOTL1 ARHGAP29 BMP4 DLG1 FGFR1 IRF6
8	cardiovascular system	MP:0005385	10.1	AMOTL1 BMP4 CDH1 CEP120 FGFR1 INTU
9	skeleton	MP:0005390	10.07	ARHGAP29 BMP4 CEP120 DLG1 FGFR1 INTU
10	mortality/aging	MP:0010768	9.86	AMOTL1 ARHGAP29 BMP4 CDH1 CEP120 DLG1
11	vision/eye	MP:0005391	9.85	AMOTL1 BMP4 DLG1 FGFR1 INTU MSX1
12	integument	MP:0010771	9.32	BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1

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Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Rocuronium

Approved

Phase 4

119302-91-9, 143558-00-3

441290

2

Dexmedetomidine

Approved, Experimental, Vet_approved

Phase 4

86347-14-0, 113775-47-6

68602 5311068

3

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1, 1867-66-9

3821

4

Sevoflurane

Approved, Vet_approved

Phase 4

28523-86-6

5206

5

Remifentanil

Approved

Phase 4

132875-61-7

60815

6

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

7

Methylene blue

Approved, Investigational

Phase 4

61-73-4

6099

8

Clindamycin

Approved, Vet_approved

Phase 4

18323-44-9, 24729-96-2

29029

9

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

10

Neurotransmitter Agents

Phase 4

11

Adrenergic alpha-Agonists

Phase 4

12

Adrenergic Agonists

Phase 4

13

Adrenergic Agents

Phase 4

14

Excitatory Amino Acid Antagonists

Phase 4

15

Anesthetics, Dissociative

Phase 4

16

Hypnotics and Sedatives

Phase 4

17

Analgesics

Phase 4

18

Anesthetics

Phase 4

19

Analgesics, Non-Narcotic

Phase 4

20

Anti-Bacterial Agents

Phase 4

21

Fibrin Tissue Adhesive

Phase 4

22

Penicillins

Phase 4

23

Antibiotics, Antitubercular

Phase 4

24

Hemostatics

Phase 4

25

Clindamycin phosphate

Phase 4

32603

26

Clindamycin palmitate

Phase 4

27

Antirheumatic Agents

Phase 4

28

Cyclooxygenase Inhibitors

Phase 4

29

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

30

Anti-Inflammatory Agents

Phase 4

31

Fentanyl

Approved, Illicit, Investigational, Vet_approved

437-38-7

3345

32

Morphine

Approved, Investigational

57-27-2

5288826

33

Anesthetics, Intravenous

34

Anesthetics, General

35

Analgesics, Opioid

36

Narcotics

37

Daminozide

1596-84-5

15331

38

Calcium, Dietary

39

Calcium

Nutraceutical

7440-70-2

271

Interventional clinical trials:

(show top 50) (show all 71)

#	Name	Status	NCT ID	Phase	Drugs
1	Opioid Free Anaesthesia vs Opioid Based Anesthesia in Cleft Lip, Palate ,Alveolus Surgery.	Unknown status	NCT04081909	Phase 4	Fentanyl，Remifentanil;Ketamine,Dexmedetomidine
2	Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical Trial	Recruiting	NCT04234971	Phase 4	Intervention group (DBM/BMP);Control group(autologous ICBG)
3	Ketorolac in Palatoplasty: A Randomized Blinded Controlled Trial.	Recruiting	NCT04771156	Phase 4	Ketorolac;Placebo
4	Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair	Completed	NCT03766217	Phase 3
5	Distraction Versus Orthognathic Surgery - Which One is Better for Cleft Palate Patients	Completed	NCT00930124	Phase 2
6	Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial	Unknown status	NCT03011489
7	Stability of One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy: A Prospective Study	Unknown status	NCT01871623
8	Three-dimensional Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty: Classic and Geometric Morphometric Evaluation	Unknown status	NCT03839290
9	Microimplant-assisted Rapid Palatal Expansion Appliance to Orthopedically Correct Midface Deficiency in Patients With Cleft Lip and Palate: a Randomized Clinical Trial	Unknown status	NCT04354116
10	Transverse Dento-skeletal Effects of Two Rapid Palatal Expansion Appliances in Cleft Lip and Palate Patients : A Randomized Clinical Trial	Unknown status	NCT04236466
11	Distribution Of ABO Blood Groups In Relation To Cleft Lip And/or Palate .	Unknown status	NCT03217890
12	Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate: A Cross Sectional Study	Unknown status	NCT03219021
13	Osteogenesis and Dental Eruption Through Electrical Stimuli Following Periosteoplasty for Alveolar Clefts in Patients With Cleft Lip and Palate Deformities. A Preliminary Report.	Unknown status	NCT00975208
14	The Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Between Patients With and Without Pre-Alveolar Bone Graft Orthodontic Treatment	Unknown status	NCT02454998
15	OSAS in Children With Cleft Lip/Palate	Completed	NCT00156442
16	Efficacy of Nasoalveolar Molding Therapy for Treatment of Unilateral Cleft Lip and Palate in Egyptian Infants	Completed	NCT03029195
17	Effectiveness of Nasal-alar Elevator (NE) Combined With Taping Vs. Taping Alone on Improving the Nose Esthetics and Maxillary Arch Dimensions in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Clinical Trial	Completed	NCT04331379
18	Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients	Completed	NCT01932164
19	The Effect of a Newly Designed Presurgical Orthopedic Appliance on Maxillary Arch Dimensions in Infants With Bilateral Cleft Lip and Palate: Randomized Clinical Trial	Completed	NCT05535530
20	Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Pain-related Temporomandibular Disorders	Completed	NCT03308266
21	Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients	Completed	NCT03686761
22	Comparison of Cleft Lip and Palate Between a United States Tertiary Care Center and a Guatemalan Surgical Mission: A Cohort Study of 629 Pediatric Patients and a Survey of Risk Factors	Completed	NCT04725370
23	Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate	Completed	NCT02789787
24	Unilateral Cleft Repair in One Surgery With Pure Primary Healing	Completed	NCT04108416
25	Otologic and Rhinologic Outcomes in Children With Cleft Palate at Age 10 Years	Completed	NCT03708406
26	Ultrasound Diagnosis of Cleft Lip and Palate - FENCHU	Completed	NCT03582111
27	Functional Outcomes of Cleft Lip and Lip Revision Surgery	Completed	NCT00070811
28	Efficacia Del Trattamento Chirurgico Maxillo-facciale Sul Volto Dei Bambini Con Labiopalatoschisi: Valutazioni Estetiche ed Ortodontiche	Completed	NCT03395015
29	Clinical, Volumetric and Densitometric Evaluation of Tissue Engineered (TE) Constructs for Secondary Alveolar Cleft Reconstruction (Short Term Randomized Controlled Clinical Trial)	Completed	NCT03563495
30	Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients. A Prospective Randomized Trial	Completed	NCT02329509
31	Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion: A Case Series	Completed	NCT03976609
32	Effect of A Novel (Modified Grayson) Technique for Nasoalveolar Molding and Taping on Parents' Satisfaction and Short Term Treatment Outcomes in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Controlled Trial	Completed	NCT02845193
33	Correlation Between Body Mass Index and Progressive Bone Mineral Density in Cleft Patients After Secondary Alveolar Bone Grafting	Completed	NCT05002920
34	Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial	Completed	NCT02881606
35	Progressive Comparison of Density Assessment of Alveolar Bone Graft in Patients With Unilateral and Bilateral Cleft	Completed	NCT04987190
36	Articulatory and Phonological Competence at 3 and 5 Years of Age in Children With Unilateral Cleft Lip and Palate Who Have Undergone Different Methods of Primary Palatal Surgery	Completed	NCT00829101
37	Emergence Delirium and Recovery Profile in Patients Undergoing Cleft Lip and Palate Repair: Comparison of Combination of Morphine and Fentanyl With Fentanyl Alone	Completed	NCT03010540		MORPHINE PLUS FENTANYL;Fentanyl
38	The Effect of the Usage of Squeezable vs Standard Bottles on the Feeding Process of Infants With Cleft Lip and Palate (CLP) After Cleft Palate Surgery	Completed	NCT05062798
39	Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate	Completed	NCT03549039
40	Follow Ups of Parents With Infants With Cleft Lip and Palate	Completed	NCT02415361
41	Influence of Presurgical Orthodontic Molding on the Growth of Newborns With Unilateral Cleft Lip Palate: a Prospective, Randomized, Clinical Trial	Recruiting	NCT05081258
42	Short Term Efficiency of Presurgical Vacuum Formed Nasoalveolar Molding Aligners in Infants With Bilateral Cleft Lip and Palate Compared With Conventional Grayson Acrylic Formed Nasoalveolar Molding Appliances: A Randomized Clinical Trial	Recruiting	NCT04966572
43	Collaborative, Comparative Study on Three-dimensional Cleft Lip and Palate Morphology Prior to One-stage Cleft Repair (Warsaw/Basel)	Recruiting	NCT04616690
44	Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC	Recruiting	NCT03065686
45	Effectiveness of Two Rapid Maxillary Expanders (Quadhelix vs Hyrax) in Improving the Transverse Skeletal and Dental Dimensions in Patients With Cleft Lip and Palate: A Randomized Clinical Trial	Recruiting	NCT04331977
46	Does an Audio-visual Aid Reduce Anxiety and Improve the Understanding of Children Undergoing an Alveolar Bone Graft: Randomised Control Trial	Recruiting	NCT04381078
47	Augmented Reality (AR): The Future of "Patient Information Leaflets	Recruiting	NCT04619030
48	Evaluation of Dental Age of Children With Cleft Lip and Palate Using Willems Method, Cameriere European Formula, and London Atlas	Recruiting	NCT05573295
49	Intraoperative Assessment of the Influence of Cleft Repair on Microcirculation of the Palate	Recruiting	NCT03877666
50	Simplifying Home Weight Monitoring for Infants With Cleft Lip and/or Palate Differences to Determine if Use of an In-home Scale Leads to Better Compliance With Weight Monitoring Recommendations	Recruiting	NCT04384276

Search NIH Clinical Center for Cleft Lip/palate

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Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

#	Genetic test	Affiliating Genes
1	Cleft Lip/palate ²⁸

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Anatomical Context for Cleft Lip/palate

Organs/tissues related to Cleft Lip/palate:

MalaCards : Bone, Bone Marrow, Tongue, Heart, Skin, Lung, Eye

Sources

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 8850)

#	Title	Authors	PMID	Year
1	Dental anomalies and their therapeutic implications: retrospective assessment of a frequent finding in patients with cleft lip and palate. ⁶² ⁴¹	Sander AK...Lethaus B	36457084	2022
2	Comparison of prenatal ultrasound with MRI in the evaluation and prediction of fetal orofacial clefts. ⁴¹	Gai S...Zheng W	36471263	2022
3	Orofacial clefts lead to increased pro-inflammatory cytokine levels on neonatal oral mucosa. ⁴¹	Seidel CL...Golz L	36466891	2022
4	Definitive Rhinoplasty and Orthognathic Surgery for Patients with Cleft Lip Palate. ⁶²	Eldesouky R...Elbarbary A	36336595	2023
5	A CBCT Study for Anatomic Variations of Osteomeatal complex in Patients With Cleft Lip and Palate. ⁶²	Goksel S...Ozcan I	34787479	2023
6	Cranial Base Angle in Patients With Cleft Lip and Palate-A Systematic Review and Meta-Analysis. ⁶²	Murugan C...Kailasam V	34787478	2023
7	Comparison of Preoperative Measurement Methods of Alveolar Cleft Volume Using Cone Beam Computed Tomography between Computer Simulation and Water Displacement Methods. ⁶²	Phienwej K...Sriwilas P	34841928	2023
8	Six-year Burden of Care for Nonsyndromic Unilateral Cleft Lip and Palate Patients: A Comparison Between Cleft Centers and Noncleft Centers. ⁶²	Janssen PL...Dagum AB	34786981	2023
9	Do Orofacial Clefts Impair Breastfeeding and Increase the Prevalence of Anemia? ⁶²	Miranda-Filho AEF...Marques NCT	34755566	2023
10	Isolation, Uncertainty and Treatment Delays: Parents' Experiences of Having a Baby with Cleft Lip/Palate During the Covid-19 Pandemic. ⁶²	Costa B...Stock NM	34841909	2023
11	Tenofovir Alafenamide for Pregnant Chinese Women With Active Chronic Hepatitis B: A Multicenter Prospective Study. ⁶²	Zeng QL...Wang FS	34902570	2022
12	Rhinoplasty in a 3 Week Old: Surgical Challenges in the Setting of Severe Congenital Frontonasal Dysplasia. ⁶²	Lopez A...Bennett E	35043659	2022
13	The Early Operative Burden for Children Born with Cleft lip and Palate. ⁶²	Fink T...Penington T	36464652	2022
14	Long-Term Follow-up of Unilateral Cleft lip and Palate: Incidence of Speech-Correcting Surgeries and Fistula Formation. ⁶²	Gustafsson C...Leikola J	34866444	2022
15	mir152 hypomethylation as a mechanism for non-syndromic cleft lip and palate. ⁶²	Alvizi L...Passos-Bueno MR	36047706	2022
16	The Incidence and Outcomes for Children with Cleft Palate and/or Lip and CHARGE Syndrome. ⁶²	Farid M...Slator R	36471495	2022
17	Quality-of-life improvement, psychosocial benefits, and patient satisfaction of patients undergoing orthognathic surgery: a summary of systematic reviews. ⁶²	Cremona M...Abela S	35511144	2022
18	Psychosocial Experiences That Support Positive Self-Concept in Children with Cleft Lip and Palate Adopted From China. ⁶²	Everhart SA...Marik PK	34860609	2022
19	Predictors of Complication Following Cleft Lip and Palate Surgery in a Low-Resource Setting: A Prospective Outcomes Study in Nicaragua. ⁶²	Swanson MA...Swanson JW	34658290	2022
20	The Panorama of Cleft Lip and Palate Live Birth in Brazil: Follow-up of a 10-Year Period and Inequalities in the Health System. ⁶²	Silva RS...Pinto RDS	34787490	2022
21	Late alveolar bone grafting in complete unilateral cleft lip and palate (UCLP): Biomechanical considerations for the success of orthodontic finishing. ⁶²	Turri de Castro Ribeiro T...Janson G	35323076	2022
22	Three-dimensional volumetric changes in the airway of growing unilateral complete cleft lip and palate patients after bone-anchored maxillary protraction. ⁶²	Steegman R...Ren Y	36089443	2022
23	Does Presurgical Taping Change Nose and Lip Aesthetics in Infants with Unilateral Cleft Lip and Palate? A Randomized Controlled Trial. ⁶²	Abd El-Ghafour M...El-Gendi M	36126199	2022
24	Unilateral Cleft lip and Palate: Long-Term Results of the Malek Technique. ⁶²	de Buys Roessingh A...El Ezzi O	36453758	2022
25	Correction of a prominent premaxilla in a juvenile with a bilateral cleft lip and palate using a novel, hybrid function regulator, the FR-BCPPm, followed by preadjusted fixed appliances: A 20-year follow-up. ⁶²	Chate RA	35302415	2022
26	Early Maxillary Dentoalveolar Changes in Children with Unilateral Cleft Lip and Palate After Palatal Repair: A Pilot Study. ⁶²	Singhania S...Bhojraj N	34812086	2022
27	Effects of maxillary advancement on maxillary incisor display in patients with skeletal Class III malocclusion and cleft lip and palate. ⁶²	Bajracharya M...Wen-Ching Ko E	36117029	2022
28	Cleft lip and palate: the psychological burden of affected parents during the first three years of their children's lives. ⁶²	Lentge K...Spalthoff S	35513959	2022
29	Dynamic Change in Oral Microbiota of Children With Cleft Lip and Palate After Alveolar Bone Grafting. ⁶²	Zhang K...Jia Y	34524929	2022
30	Environmental Factors at the Periconceptional Period and the Occurrence of Cleft Lip and Palate in a Midwest Brazil Population: A Case-Control Study. ⁶²	Silvestre CMR...da Silva CAL	36069817	2022
31	Evaluation of prenatal breastfeeding workshop to inform and support mother with antenatal diagnosis of cleft lip/palate. ⁶²	Coste MC...Kadlub N	35760311	2022
32	Virtual Reality as parent education tool in pre-surgical management of cleft lip and palate affected infants-A pilot study. ⁶²	Deshmukh S...Contractor I	35397179	2022
33	Mobile Surgical Scouts Increase Surgical Access for Patients with Cleft Lip and Palate in Nepal. ⁶²	Shaye DA...Rai SM	34516932	2022
34	Bony Cartilaginous Graft in Unilateral Cleft Lip Rhinoplasty. ⁶²	Nguyen CD...Hodges JM	35901453	2022
35	Periodontal changes following distraction osteogenesis in patients with cleft lip and palate: a clinical trial. ⁶²	Moussa H...Khalil NM	36279255	2022
36	Orthodontic Retainers and the Stability of the Maxillary Arch in Unilateral Cleft lip and Palate Patients: A Systematic Review. ⁶²	Dos Santos CCO...Normando D	36444129	2022
37	Premaxillary Setback in Bilateral Cleft Lip and Palate Repair. ⁶²	Stanton E...Magee WP	36448087	2022
38	Treatment satisfaction and oral health-related quality of life in patients with cleft lip and palate after secondary alveolar bone grafting. ⁶²	Naujokat H...Terheyden H	35288012	2022
39	Quality of Life and Temporomandibular Disorders in Patients With Skeletal Class III Malocclusion With Cleft Lip and Palate. ⁶²	Olsson B...Scariot R	34636696	2022
40	Oral Rehabilitation of Bilateral Cleft Lip and Palate Patient with Simultaneous LeFort I Osteotomy and Zygomatic Implants: A Case Report. ⁶²	Goker F...Grecchi F	34713737	2022
41	Comparison of conventional impression making and intraoral scanning for the study of unilateral cleft lip and palate. ⁶²	Okazaki T...Fukui K	36371642	2022
42	Sella turcica dimensions and maxillary growth in patients with unilateral cleft lip and palate. ⁶²	Antonarakis GS...Fisher DM	35697253	2022
43	Clinical report: Chronic liver dysfunction in an individual with an AMOTL1 variant. ⁶²	Kirino S...Kashimada K	36116699	2022
44	A Custom Stabilizing Splint for the Management of BLCP with Protruding Premaxilla. ⁶²	Scott K...Gociman B	36381491	2022
45	Secondary Cleft Rhinoplasty: A National Survey of Surgical Practice by Accredited Cleft Palate Teams. ⁶²	Shah ND...Gosain AK	36381488	2022
46	Using whole exome sequencing to identify susceptibility genes associated with nonsyndromic cleft lip with or without cleft palate. ⁶²	Fu Z...Xiao W	36322204	2022
47	Current Presurgical Infant Orthopedics Practices Among American Cleft Palate Association-Approved Cleft Teams in North America. ⁶²	Avinoam SP...Shetye PR	36409871	2022
48	Assessment of Internal Nasal Dimensions of Individuals With Cleft Lip and Palate and Obstructive Sleep Apnea Syndrome by Computed Tomography. ⁶²	Loureiro NB...Trindade SHK	36330652	2022
49	Management of Ankyloglossia in a Six-Year-Old Child After Cleft Lip and Palate Surgery: A Case Report. ⁶²	Kabra S...Khubchandani M	36475118	2022
50	An infant with ankyloblepharon filiforme adnatum associated with a cleft lip and palate. ⁶²	Zvizdic D...Vranic S	35697618	2022

Sources

Genes for Cleft Lip/palate

Genes related to Cleft Lip/palate (10 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	DLX4	Distal-Less Homeobox 4	Protein Coding	350	Causative germline mutation ⁵⁸	25954033
2	TP63	Tumor Protein P63	Protein Coding	53.38	Susceptibility factor ⁵⁸ GeneCards inferred via : Disorders Publications Summaries (show sections)	16740912 21567929
3	IRF6	Interferon Regulatory Factor 6	Protein Coding	42.76	Susceptibility factor ⁵⁸ GeneCards inferred via : Disorders Publications (show sections)	17438386
4	NECTIN1	Nectin Cell Adhesion Molecule 1	Protein Coding	42.63	Susceptibility factor ⁵⁸ GeneCards inferred via : Disorders Publications (show sections)	16674562
5	ARHGAP29	Rho GTPase Activating Protein 29	Protein Coding	25	Susceptibility factor ⁵⁸	27350171
6	BMP4	Bone Morphogenetic Protein 4	Protein Coding	25	Susceptibility factor ⁵⁸	22978696
7	CDH1	Cadherin 1	Protein Coding	25	Susceptibility factor ⁵⁸	23197654
8	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	25	Susceptibility factor ⁵⁸	28926086
9	MSX1	Msh Homeobox 1	Protein Coding	25	Susceptibility factor ⁵⁸	12807959
10	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	25	Susceptibility factor ⁵⁸	35147171
11	AMOTL1	Angiomotin Like 1	Protein Coding	25	Likely pathogenic ⁵
12	EEC1	Ectrodactyly, Ectodermal Dysplasia And Cleft Lip/Palate Syndrome 1	Genetic Locus	18.27	GeneCards inferred via : Publications Gene name (show sections)
13	TGFA	Transforming Growth Factor Alpha	Protein Coding	18.05	GeneCards inferred via : Publications Summaries (show sections)
14	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	16.89	GeneCards inferred via : Disorders Publications (show sections)
15	EEC2	Ectrodactyly, Ectodermal Dysplasia And Cleft Lip/Palate Syndrome 2	Uncategorized	8.75	GeneCards inferred via : Gene name (show sections)
16	INTU	Inturned Planar Cell Polarity Protein	Protein Coding	8	GeneCards inferred via : Disorders (show sections)
17	MID1	Midline 1	Protein Coding	8	GeneCards inferred via : Disorders (show sections)
18	WDR35	WD Repeat Domain 35	Protein Coding	8	GeneCards inferred via : Disorders (show sections)
19	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	8	GeneCards inferred via : Disorders (show sections)
20	CEP120	Centrosomal Protein 120	Protein Coding	7.65	GeneCards inferred via : Disorders (show sections)
21	DYNC2H1	Dynein Cytoplasmic 2 Heavy Chain 1	Protein Coding	7.65	GeneCards inferred via : Disorders (show sections)

Sources

Variations for Cleft Lip/palate

ClinVar genetic disease variations for Cleft Lip/palate:

⁵

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	AMOTL1	NM_130847.3(AMOTL1):c.479C>T (p.Pro160Leu)	SNV	Likely Pathogenic	929484	rs1951433087	GRCh37: 11:94532835-94532835 GRCh38: 11:94799669-94799669
2	CDH1	NM_004360.5(CDH1):c.895G>A (p.Ala299Thr)	SNV	Uncertain Significance	979047	rs1960837744	GRCh37: 16:68845649-68845649 GRCh38: 16:68811746-68811746
3	CDH1	NM_004360.5(CDH1):c.1926C>A (p.Tyr642Ter)	SNV	Uncertain Significance	979049	rs1961172043	GRCh37: 16:68856118-68856118 GRCh38: 16:68822215-68822215

Sources

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Sources

Pathways for Cleft Lip/palate

Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.43	AMOTL1 ARHGAP29 CDH1 DLG1 FGFR1 INTU
2	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.13	TGFA PDGFRA NECTIN1 FGFR1 CDH1 BMP4
3	Nanog in Mammalian ESC Pluripotency ⁶⁴ Show member pathways 14-3-3 Induced Intracellular Signaling ⁶⁴ eNOS Signaling ⁶⁴ GSK3 Signaling ⁶⁴	13.08	YAP1 TGFA PDGFRA FGFR1 CDH1 BMP4
4	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.43	TGFA PDGFRA IRF6 FGFR1 BMP4
5	Malignant pleural mesothelioma ⁷⁴	12.41	YAP1 TGFA PDGFRA FGFR1 CDH1
6	Tyrosine Kinases / Adaptors ³	11.84	YAP1 TGFA PDGFRA FGFR1
7	Gastrulation ⁶⁶ Show member pathways Epithelial-Mesenchymal Transition (EMT) during gastrulation ⁶⁶ Formation of axial mesoderm ⁶⁶ Formation of lateral plate mesoderm ⁶⁶ Formation of paraxial mesoderm ⁶⁶ Germ layer formation at gastrulation ⁶⁶	11.77	YAP1 FGFR1 BMP4
8	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	11.72	TGFA PDGFRA FGFR1 DLG1 CDH1 BMP4
9	Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers ⁶⁵	11.68	TP63 MSX1 IRF6 BMP4
10	Angiogenesis (CST) ³	11.64	TGFA PDGFRA FGFR1
11	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11.55	PDGFRA FGFR1 BMP4
12	G-protein signaling_RhoA regulation pathway ²²	11.53	TGFA PDGFRA FGFR1 BMP4
13	Head and neck squamous cell carcinoma ⁷⁴	11.5	FGFR1 IRF6 TP63
14	Neural crest differentiation ⁷⁴	11.46	MSX1 FGFR1 CDH1 BMP4
15	Hair follicle development: cytodifferentiation - part 3 of 3 ⁷⁴	11.34	TP63 MSX1 BMP4
16	Signaling by Hippo ⁶⁶	10.88	YAP1 AMOTL1
17	BMP signaling in eyelid development ⁷⁴	10.87	TGFA BMP4
18	G-protein signaling_Rap2B regulation pathway ²²	10.8	TGFA PDGFRA FGFR1 CDH1 BMP4
19	Hypothetical craniofacial development pathway ⁷⁴ Show member pathways p63 transcription factor network ⁶¹	9.75	TP63 IRF6 ARHGAP29

Sources

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell junction	GO:0030054	9.32	YAP1 PDGFRA IRF6 DLG1 CDH1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of cell population proliferation	GO:0008284	10.1	YAP1 TP63 TGFA PDGFRA FGFR1 DLG1
2	embryonic digit morphogenesis	GO:0042733	9.92	MSX1 INTU BMP4
3	embryonic skeletal system morphogenesis	GO:0048704	9.88	PDGFRA DLG1 BMP4
4	positive regulation of phospholipase C activity	GO:0010863	9.86	PDGFRA FGFR1
5	roof of mouth development	GO:0060021	9.86	INTU IRF6 MSX1 PDGFRA
6	embryonic hindlimb morphogenesis	GO:0035116	9.85	BMP4 MSX1 TP63
7	astral microtubule organization	GO:0030953	9.84	DLG1 CEP120
8	bud elongation involved in lung branching	GO:0060449	9.81	BMP4 YAP1
9	BMP signaling pathway involved in heart development	GO:0061312	9.8	BMP4 MSX1
10	keratinocyte differentiation	GO:0030216	9.76	YAP1 TP63 IRF6 INTU
11	prostatic bud formation	GO:0060513	9.73	TP63 BMP4
12	cloacal septation	GO:0060197	9.71	TP63 BMP4
13	embryonic limb morphogenesis	GO:0030326	9.63	TP63 MSX1 BMP4
14	odontogenesis of dentin-containing tooth	GO:0042475	9.56	TP63 PDGFRA MSX1 BMP4
15	embryo development	GO:0009790	9.55	DLX4 DLG1
16	stem cell proliferation	GO:0072089	9.1	YAP1 TP63 IRF6 CEP120

Sources

Sources for Cleft Lip/palate

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

FLP MCID: CLF004 MIFTS: 57	Cleft Lip/palate (FLP) Categories: Ear diseases, Fetal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

Cleft Lip/palate (FLP)

Aliases & Classifications for Cleft Lip/palate

MalaCards integrated aliases for Cleft Lip/palate:

Characteristics:

Inheritance:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for Cleft Lip/palate

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Cleft Lip/palate:

Symptoms & Phenotypes for Cleft Lip/palate

Human phenotypes related to Cleft Lip/palate:

MGI Mouse Phenotypes related to Cleft Lip/palate:

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

Anatomical Context for Cleft Lip/palate

Organs/tissues related to Cleft Lip/palate:

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

Genes for Cleft Lip/palate

Genes related to Cleft Lip/palate (10 elite genes):

Variations for Cleft Lip/palate

ClinVar genetic disease variations for Cleft Lip/palate:

Expression for Cleft Lip/palate

Pathways for Cleft Lip/palate

Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

Sources for Cleft Lip/palate