Cleft Lip/palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 43 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 1 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Hippo signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Fibrin Tissue Adhesive and Coagulants have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are growth/size/body region and embryo

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 35.1 EEC1 TP63
2 short-rib thoracic dysplasia 1 with or without polydactyly 32.4 CEP120 IFT140 WDR34
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.3 CEP120 KIAA0586 NEK1 TCTEX1D2 WDR34
4 isolated cleft lip 31.0 IRF6 MSX1 NECTIN1 TP63
5 tooth agenesis 28.5 BMP4 CDH1 FGFR1 IRF6 MSX1
6 cleft palate, isolated 28.4 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
7 cleft lip 27.8 ARHGAP29 BMP4 CDH1 DLX4 EEC1 FGFR1
8 cleft lip/palate-ectodermal dysplasia syndrome 12.7
9 ankyloblepharon-ectodermal defects-cleft lip/palate 12.7
10 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.7
11 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.6
12 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.6
13 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.4
14 cleft lip/palate with abnormal thumbs and microcephaly 12.3
15 polydactyly cleft lip palate psychomotor retardation 12.3
16 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.3
17 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.3
18 cleft lip palate pituitary deficiency 12.2
19 cleft lip palate-tetraphocomelia 12.2
20 radius, aplasia of, with cleft lip/palate 12.2
21 craniosynostosis cleft lip palate arthrogryposis 12.2
22 holoprosencephaly ectrodactyly cleft lip palate 12.2
23 cleft lip/palate-deafness-sacral lipoma syndrome 12.2
24 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.2
25 lagophthalmia cleft lip palate 12.2
26 cleft lip palate dysmorphism kumar type 12.2
27 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.2
28 cleft lip palate oligodontia syndactyly pili torti 12.2
29 tibial hemimelia cleft lip palate 12.2
30 popliteal pterygium syndrome 12.1
31 hartsfield syndrome 12.0
32 rapp-hodgkin syndrome 12.0
33 vici syndrome 11.9
34 acrofrontofacionasal dysostosis 11.9
35 cleft palate, cardiac defects, and mental retardation 11.8
36 zlotogora syndrome 11.8
37 richieri-costa/guion-almeida syndrome 11.7
38 uveal coloboma-cleft lip and palate-intellectual disability 11.7
39 martinez monasterio pinheiro syndrome 11.5
40 roberts syndrome 11.4
41 kapur-toriello syndrome 11.4
42 acrofrontofacionasal dysostosis 1 11.3
43 orofaciodigital syndrome vi 11.3
44 sakoda complex 11.3
45 crane-heise syndrome 11.3
46 medeira-dennis-donnai syndrome 11.3
47 short-rib thoracic dysplasia 7 with or without polydactyly 11.2
48 short-rib thoracic dysplasia 6 with or without polydactyly 11.2
49 short-rib thoracic dysplasia 5 with or without polydactyly 11.2
50 short-rib thoracic dysplasia 9 with or without polydactyly 11.2

Graphical network of the top 20 diseases related to Cleft Lip/palate:

Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

MGI Mouse Phenotypes related to Cleft Lip/palate:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.38 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
2 embryo MP:0005380 10.34 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
3 craniofacial MP:0005382 10.3 BMP4 DLG1 FGFR1 IFT140 IRF6 KIAA0586
4 cellular MP:0005384 10.28 BMP4 CDH1 CEP120 DLG1 FGFR1 IFT140
5 mortality/aging MP:0010768 10.27 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
6 cardiovascular system MP:0005385 10.25 CDH1 CEP120 FGFR1 IFT140 KIAA0586 MEIS2
7 digestive/alimentary MP:0005381 10.25 BMP4 CDH1 DLG1 FGFR1 IFT140 IRF6
8 integument MP:0010771 10.09 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
9 limbs/digits/tail MP:0005371 10.01 BMP4 DLG1 FGFR1 IFT140 IRF6 KIAA0586
10 nervous system MP:0003631 10 BMP4 CEP120 DLG1 FGFR1 IFT140 KIAA0586
11 hearing/vestibular/ear MP:0005377 9.93 BMP4 FGFR1 IFT140 IRF6 MEIS2 MSX1
12 muscle MP:0005369 9.87 FGFR1 MID1 MSX1 TP63 YAP1 BMP4
13 skeleton MP:0005390 9.73 FGFR1 IFT140 IRF6 KIAA0586 MEIS2 MSX1
14 renal/urinary system MP:0005367 9.7 BMP4 DLG1 FGFR1 IFT140 NEK1 TP63
15 vision/eye MP:0005391 9.23 MSX1 NECTIN1 TP63 BMP4 DLG1 FGFR1

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 4
2 Coagulants Phase 4
3 Hemostatics Phase 4
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Micronutrients Phase 3
7 Hematinics Phase 3
8 Trace Elements Phase 3
9 Vitamin B Complex Phase 3
10 Vitamins Phase 3
11 Folate Nutraceutical Phase 3
12 Vitamin B9 Nutraceutical Phase 3
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
Acetaminophen Approved Phase 2 103-90-2 1983
17 Analgesics Phase 2,Not Applicable
18 Central Nervous System Depressants Phase 2,Not Applicable
19 Anesthetics Phase 2,Not Applicable
20 Peripheral Nervous System Agents Phase 1, Phase 2,Phase 2,Not Applicable
21 abobotulinumtoxinA Phase 1, Phase 2
22 Adrenergic Agents Phase 2
23 Adrenergic Agonists Phase 2
24 Adrenergic alpha-2 Receptor Agonists Phase 2
25 Adrenergic alpha-Agonists Phase 2
26 Cholinergic Agents Phase 1, Phase 2
27 Neuromuscular Agents Phase 1, Phase 2
28 Neurotransmitter Agents Phase 1, Phase 2,Phase 2
29 Analgesics, Non-Narcotic Phase 2
30 Anesthetics, Local Phase 2
31 onabotulinumtoxinA Phase 1, Phase 2
32 Hypnotics and Sedatives Phase 2
33 Antipyretics Phase 2
34 Botulinum Toxins, Type A Phase 1, Phase 2
35 Botulinum Toxins Phase 1, Phase 2
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
38 Adjuvants, Anesthesia Not Applicable
39 Narcotics Not Applicable
40 Analgesics, Opioid Not Applicable
41 Anesthetics, General Not Applicable
42 Anesthetics, Intravenous Not Applicable

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
6 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
7 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
8 Suprazygomatic Block in Cleft Palate Surgery in Children Recruiting NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
10 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
11 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
12 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
13 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
14 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
15 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
16 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
17 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
18 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
19 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
20 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
21 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
22 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
23 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
24 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
25 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
26 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
27 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
28 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
29 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
30 Svangerskap, Arv, og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
31 Child and Infant Learning Project Completed NCT00077831
32 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
33 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Recruiting NCT03029195 Not Applicable
34 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606 Not Applicable
35 Efficiency of Novel Nasoalveolar Molding Method on Parents' Satisfaction in Unilateral Cleft Infants Recruiting NCT02845193 Not Applicable
36 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686 Not Applicable
37 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
38 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
39 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
40 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Recruiting NCT02900014 Not Applicable
41 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Recruiting NCT03165331 Not Applicable
42 Targeting Surgeons' Decision-Making for Cleft Lip Surgery Recruiting NCT03537976 Not Applicable
43 Follow Ups of Parents With Infants With Cleft Lip and Palate Active, not recruiting NCT02415361 Not Applicable
44 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489 Not Applicable
45 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate Not yet recruiting NCT03219021
46 Three Dimensional Facial Growth Analysis Not yet recruiting NCT03514563
47 Use of Titanium Plate in Rhinoplasty in Patients With Cleft Lip and Palate : Aesthetic and Functional Impact. Not yet recruiting NCT03572907
48 the Relationship Between Cleft Lip and / or Palate (Different Types) and ABO Blood Groups. Not yet recruiting NCT03217890
49 Effect of Alveolar Bone Grafting Not yet recruiting NCT03549039
50 TWIST Human Gene and Cleft Lips and Palates Terminated NCT00213889 Not Applicable

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

Bone, Heart, Skin, Testes, Kidney, Tongue, Pituitary

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 973)
# Title Authors Year
The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients. ( 29619373 )
Rethinking isolated cleft lip and palate as a syndrome. ( 29500156 )
Effects of Nasoalveolar Molding Therapy on Alveolar and Palatal Cleft Deformities in Unilateral and Bilateral Cleft Lip and Palate. ( 29381641 )
Cleft Lip and Palate in CHARGE Syndrome: Phenotypic Features That Influence Management. ( 29437513 )
The Impact of Maxillary Advancement on Consonant Proficiency in Patients With Cleft Lip and Palate, Lay Listeners' Opinion, and Patients' Satisfaction With Speech. ( 29949386 )
A case of cleft lip and palate with severe maxillary retrognathism treated by distraction osteogenesis and custom made intraoral rapid maxillary expansion appliance: A 2-year follow-up of retention. ( 29937663 )
Acoustic analysis of misarticulated trills in cleft lip and palate children. ( 29960457 )
Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. ( 29388416 )
Long-Term Skeletal Changes After Maxillary Distraction Osteogenesis in Growing Children With Cleft Lip/Palate. ( 29461366 )
3D Assessment of Nasolabial Appearance in Patients With Complete Unilateral Cleft Lip and Palate. ( 29351025 )
The use of throat packs in pediatric cleft lip/palate surgery: a retrospective study. ( 29473105 )
A Case of Ankyloblepharon-ectodermal Defects-cleft Lip/palate-syndrome with Choanal Atresia and Skin Erosions: Phenotypic Variability of TP63-related Disorders. ( 29956718 )
Bone-anchored maxillary protraction in a patient with complete cleft lip and palate: A case report. ( 29407507 )
Tooth-borne distraction osteogenesis versus conventional Le Fort I in maxillary advancement of cleft lip and palate patients. ( 29388417 )
BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate. ( 29921024 )
Novel <i>TBX22</i> mutations in Chinese nonsyndromic cleft lip/palate families. ( 29932061 )
Influence of involuntary facial expressions on reproducibility of 3D stereophotogrammetry in children with and without complete unilateral cleft lip and palate from 3 to 18A months of age. ( 29943366 )
Comprehensive Genetic Screening Recommended for Nonsyndromic Cleft Lip/Palate: Even in the absence of any signs of a syndrome, patients with cleft lip/palate may still carry a mutation in a gene linked to a syndrome and should receive comprehensive genetic testing. ( 29878711 )
PVR/CD155 Ala67Thr Mutation and Cleft Lip/Palate. ( 29381645 )
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P). ( 29371764 )
Single-Stage Primary Cleft Lip and Palate Repair: A Review of the Literature. ( 29944528 )
A Comparative Evaluation of Efficacy and Efficiency of Grayson's Presurgical Nasoalveolar Molding Technique in Patients with Complete Unilateral Cleft Lip and Palate with Those Treated with Figueroa's Modified Technique. ( 29962760 )
Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. ( 28967531 )
3D-Printed Models of Cleft Lip and Palate for Surgical Training and Patient Education. ( 29437509 )
A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. ( 29524576 )
Evaluation of Airway Volume in Cleft Lip and Palate Following Nasoalveolar Molding. ( 29944553 )
Minimally invasive versus standard approach in LeFort 1 osteotomy in patients with history of cleft lip and palate. ( 29408322 )
Three-dimensional radiological evaluation of secondary alveolar bone grafting in cleft lip and palate patients: a systematic review. ( 29947253 )
A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. ( 29173718 )
Quantifying Soft Tissue Shape and Symmetry: Patients with Cleft Lip/Palate and Facial Paralysis. ( 29707466 )
The Effect of Nasoalveolar Molding on Nasal Airway Anatomy: A 9-Year Follow-up of Patients With Unilateral Cleft Lip and Palate. ( 29356619 )
Prevalence of Cleft Lip/Palate in the Fangshan District of Beijing, 2006-2012. ( 29601215 )
Nonsyndromic cleft lip and palate, gastric cancer and tooth agenesis. ( 29274157 )
Cleft Lip and Palate: An Experience of a Developing Center in Egypt. ( 28922239 )
A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management. ( 28218559 )
Effect of Presurgical Nasoalveolar Molding on Nasal Symmetry in Unilateral Complete Cleft Lip/Palate Patients After Primary Cheiloplasty Without Concomitant Nasal Cartilage Dissection: Early Childhood Evaluation. ( 28085515 )
Cleft Lip and Palate Repair: Our Experience. ( 28906329 )
The Serological Evidence of Cytomegalovirus Infection as a Potent Aetiological Factor for Cleft Lip/Palate, Mental Retardation and Deafness. ( 28764293 )
The impact and cost-effectiveness of the Amref Health Africa-Smile Train Cleft Lip and Palate Surgical Repair Programme in Eastern and Central Africa. ( 29184597 )
A Comparative Study of Oral Microbiota in Infants with Complete Cleft Lip and Palate or Cleft Soft Palate. ( 28393073 )
Patient and parent reported outcome measures in cleft lip and palate patients before and after secondary alveolar bone grafting. ( 29384973 )
A Family With Craniofrontonasal Syndrome: The First Report of Familial Cases of Craniofrontonasal Syndrome With Bilateral Cleft Lip and Palate. ( 28140668 )
Three-dimensional printed haptic model from a prenatal surface-rendered oropalatal sonographic view: a new tool in the surgical planning of cleft lip/palate. ( 28673724 )
The Americleft Project: A Modification of Asher-McDade Method for Rating Nasolabial Esthetics in Patients With Unilateral Cleft Lip and Palate Using Q-sort. ( 28906328 )
Motor behavior of masticatory muscles in individuals with unilateral trans-incisive foramen cleft lip and palate. ( 28566055 )
Early, Computer-Aided Design/Computer-Aided Modeling Planned, Le Fort I Advancement With Internal Distractors to Treat Severe Maxillary Hypoplasia in Cleft Lip and Palate. ( 28403134 )
3D analysis of effects of primary surgeries in cleft lip/palate children during the first two years of life. ( 28591242 )
Speech intelligibility after repair of cleft lip and palate. ( 29951386 )
Maxillary Anterior Segmental Distraction Osteogenesis to Correct Maxillary Deficiencies in a Patient With Cleft Lip and Palate. ( 27115561 )
Cone beam computed tomography imaging of superior semicircular canal morphology: a retrospective comparison of cleft lip/palate patients and normal controls. ( 29202612 )

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 centriole GO:0005814 9.58 CEP120 KIAA0586 WDR34
2 ciliary basal body GO:0036064 9.43 IFT140 KIAA0586 WDR34
3 cytoplasmic dynein complex GO:0005868 9.37 TCTEX1D2 WDR34
4 apical junction complex GO:0043296 9.32 CDH1 NECTIN1
5 axoneme GO:0005930 9.13 IFT140 TCTEX1D2 WDR34
6 centrosome GO:0005813 9.02 CEP120 IFT140 KIAA0586 NEK1 TCTEX1D2
7 cytoplasm GO:0005737 10 ARHGAP29 CDH1 CEP120 DLG1 FGFR1 IFT140

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 BMP4 DLG1 DLX4 FGFR1 MEIS2 MSX1
2 cell-cell adhesion GO:0098609 9.79 CDH1 DLG1 NECTIN1
3 cell morphogenesis GO:0000902 9.77 CDH1 MSX1 YAP1
4 keratinocyte differentiation GO:0030216 9.72 IRF6 TP63 YAP1
5 embryonic digit morphogenesis GO:0042733 9.7 BMP4 IFT140 MSX1
6 odontogenesis of dentin-containing tooth GO:0042475 9.65 BMP4 MSX1 TP63
7 anatomical structure formation involved in morphogenesis GO:0048646 9.64 BMP4 TP63
8 renal system development GO:0072001 9.64 BMP4 IFT140
9 intraciliary transport GO:0042073 9.63 IFT140 WDR34
10 camera-type eye morphogenesis GO:0048593 9.62 BMP4 NECTIN1
11 middle ear morphogenesis GO:0042474 9.61 FGFR1 MSX1
12 ureteric bud development GO:0001657 9.61 BMP4 DLG1 FGFR1
13 generation of neurons GO:0048699 9.6 CDH1 FGFR1
14 keratinocyte proliferation GO:0043616 9.58 IRF6 TP63
15 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.58 BMP4 MSX1
16 organ induction GO:0001759 9.57 BMP4 FGFR1
17 cilium assembly GO:0060271 9.55 IFT140 KIAA0586 NEK1 TCTEX1D2 WDR34
18 paraxial mesoderm development GO:0048339 9.54 FGFR1 YAP1
19 pituitary gland development GO:0021983 9.54 BMP4 CDH1 MSX1
20 astral microtubule organization GO:0030953 9.51 CEP120 DLG1
21 embryonic hindlimb morphogenesis GO:0035116 9.5 BMP4 MSX1 TP63
22 bud elongation involved in lung branching GO:0060449 9.49 BMP4 YAP1
23 BMP signaling pathway involved in heart development GO:0061312 9.46 BMP4 MSX1
24 cloacal septation GO:0060197 9.4 BMP4 TP63
25 embryonic limb morphogenesis GO:0030326 9.26 BMP4 FGFR1 MSX1 TP63
26 smooth muscle tissue development GO:0048745 8.8 BMP4 DLG1 TP63
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 BMP4 IRF6 MEIS2 MSX1 TP63 YAP1
28 multicellular organism development GO:0007275 10.1 BMP4 CDH1 DLX4 FGFR1 MEIS2 MSX1
29 positive regulation of transcription, DNA-templated GO:0045893 10 BMP4 CDH1 IRF6 TP63 YAP1

Sources for Cleft Lip/palate

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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