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FLP
MCID: CLF004
MIFTS: 54

Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cleft Lip/palate

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MalaCards integrated aliases for Cleft Lip/palate:

Name: Cleft Lip/palate 58 29
Cleft Lip and Palate 58 42
Cleft Lip-Alveolus-Palate Syndrome 58
Alveolar Cleft Lip and Palate 58
Flp 58

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Developmental anomalies during embryogenesis


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Summaries for Cleft Lip/palate

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MedlinePlus : 42 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and cleft lip/palate-ectodermal dysplasia syndrome. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are G-protein signaling RAC1 in cellular process and Immune response IFN alpha/beta signaling pathway. The drugs Fentanyl and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and tongue, and related phenotypes are abnormality of dental eruption and delayed speech and language development

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Related Diseases for Cleft Lip/palate

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Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 563)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 35.4 TP63 NECTIN1 EEC1
2 cleft lip/palate-ectodermal dysplasia syndrome 35.1 TP63 NECTIN1 MSX1
3 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 35.1 TP63 LOC111162620
4 popliteal pterygium syndrome 33.3 NECTIN1 MSX1 IRF6 ARHGAP29
5 orofacial cleft 8 33.1 TP63 LOC111162620 IRF6
6 short-rib thoracic dysplasia 3 with or without polydactyly 32.8 WDR35 INTU CEP120
7 bartsocas-papas syndrome 32.7 TP63 IRF6
8 short-rib thoracic dysplasia 12 32.7 WDR35 INTU CEP120
9 isolated cleft lip 31.3 TP63 NECTIN1 MSX1 IRF6
10 ectodermal dysplasia 31.3 TP63 NECTIN1 MSX1 EEC1 CDH1
11 van der woude syndrome 1 31.3 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
12 cleft lip and alveolus 30.8 TP63 NECTIN1 MSX1 IRF6
13 tooth size 30.6 MSX1 BMP4
14 chromosome 2q35 duplication syndrome 30.3 TP63 NECTIN1 MSX1 IRF6 FGFR1 BMP4
15 ankyloglossia with or without tooth anomalies 30.0 MSX1 IRF6
16 coloboma of macula 29.9 YAP1 MSX1 FGFR1 BMP4
17 anodontia 29.7 MSX1 BMP4
18 charge syndrome 29.6 MSX1 FGFR1 BMP4
19 cleft palate, isolated 29.6 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
20 cleft lip with or without cleft palate 29.5 TGFA NECTIN1 MSX1 IRF6 CDH1 BMP4
21 cleft lip 29.3 YAP1 TP63 TGFA NECTIN1 MSX1 IRF6
22 tooth agenesis 29.3 WDR35 TP63 TGFA NECTIN1 MSX1 IRF6
23 orofacial cleft 28.0 TP63 TGFA NECTIN1 MSX1 LOC111162620 IRF6
24 ankyloblepharon-ectodermal defects-cleft lip/palate 13.1
25 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 13.1
26 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 13.0
27 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.8
28 cleft lip/palate with abnormal thumbs and microcephaly 12.7
29 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.6
30 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.6
31 cleft lip/palate-deafness-sacral lipoma syndrome 12.6
32 radius, aplasia of, with cleft lip/palate 12.5
33 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.5
34 cleft lip palate dysmorphism kumar type 12.5
35 cleft lip palate oligodontia syndactyly pili torti 12.5
36 cleft lip palate pituitary deficiency 12.5
37 cleft lip palate-tetraphocomelia 12.5
38 craniosynostosis cleft lip palate arthrogryposis 12.5
39 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.5
40 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.5
41 cleft lip and palate malrotation cardiopathy 12.5
42 cleft palate, cardiac defects, and mental retardation 12.5
43 rapp-hodgkin syndrome 12.4
44 hartsfield syndrome 12.4
45 vici syndrome 12.3
46 orofaciodigital syndrome vi 12.3
47 richieri-costa/guion-almeida syndrome 12.2
48 acrofrontofacionasal dysostosis 12.2
49 pilotto syndrome 12.2
50 orofacial cleft 1 12.0

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate
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Symptoms & Phenotypes for Cleft Lip/palate

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Human phenotypes related to Cleft Lip/palate:

58 31 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of dental eruption 58 31 hallmark (90%) Very frequent (99-80%) HP:0006292
2 delayed speech and language development 58 31 frequent (33%) Frequent (79-30%) HP:0000750
3 recurrent otitis media 58 31 frequent (33%) Frequent (79-30%) HP:0000403
4 poor suck 58 31 frequent (33%) Frequent (79-30%) HP:0002033
5 oral-pharyngeal dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0200136
6 velopharyngeal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000220
7 speech articulation difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0009088
8 unilateral cleft palate 58 31 frequent (33%) Frequent (79-30%) HP:0100334
9 dental malocclusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0000689
10 conductive hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000405
11 nasal speech 58 31 occasional (7.5%) Occasional (29-5%) HP:0001611
12 malnutrition 58 31 occasional (7.5%) Occasional (29-5%) HP:0004395
13 abnormal number of permanent teeth 58 31 occasional (7.5%) Occasional (29-5%) HP:0011044
14 bilateral cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0100337
15 peg-shaped maxillary lateral incisors 58 31 occasional (7.5%) Occasional (29-5%) HP:0006342
16 palate fistula 58 31 occasional (7.5%) Occasional (29-5%) HP:0010294
17 agenesis of lateral incisor 58 31 occasional (7.5%) Occasional (29-5%) HP:0200153
18 hypoplasia of the maxilla 58 31 very rare (1%) Very rare (<4-1%) HP:0000327
19 feeding difficulties in infancy 58 Frequent (79-30%)
20 cleft palate 58 Frequent (79-30%)
21 oral cleft 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Cleft Lip/palate:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.25 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
2 embryo MP:0005380 10.21 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
3 digestive/alimentary MP:0005381 10.2 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 IRF6
4 cardiovascular system MP:0005385 10.19 BMP4 CDH1 CEP120 FGFR1 INTU MSX1
5 craniofacial MP:0005382 10.13 ARHGAP29 BMP4 DLG1 FGFR1 IRF6 MSX1
6 mortality/aging MP:0010768 10.07 ARHGAP29 BMP4 CDH1 CEP120 DLG1 FGFR1
7 integument MP:0010771 10.02 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
8 limbs/digits/tail MP:0005371 9.92 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
9 muscle MP:0005369 9.76 BMP4 DLG1 FGFR1 MSX1 TGFA TP63
10 skeleton MP:0005390 9.65 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
11 vision/eye MP:0005391 9.23 BMP4 DLG1 FGFR1 INTU MSX1 NECTIN1
Sources

Drugs & Therapeutics for Cleft Lip/palate

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Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
4
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
5
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
6
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
7
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
8
Methylene blue Approved, Investigational Phase 4 61-73-4
9
Sultamicillin Approved, Investigational Phase 4 76497-13-7
10
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
11 Platelet Aggregation Inhibitors Phase 4
12 Anesthetics, Inhalation Phase 4
13 Anti-Bacterial Agents Phase 4
14 Antibiotics, Antitubercular Phase 4
15 Anesthetics Phase 4
16 Narcotics Phase 4
17 Analgesics Phase 4
18 Anesthetics, General Phase 4
19 Analgesics, Opioid Phase 4
20 Anesthetics, Intravenous Phase 4
21 Adrenergic alpha-Agonists Phase 4
22 Excitatory Amino Acid Antagonists Phase 4
23 Anesthetics, Dissociative Phase 4
24 Adrenergic Agents Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Hypnotics and Sedatives Phase 4
27 Adrenergic Agonists Phase 4
28 Neurotransmitter Agents Phase 4
29 Fibrin Tissue Adhesive Phase 4
30 Hemostatics Phase 4
31 Clindamycin phosphate Phase 4
32 penicillins Phase 4
33 Clindamycin palmitate Phase 4
34
leucovorin Approved Phase 3 58-05-9 6006 143
35
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
36 Micronutrients Phase 3
37 Vitamins Phase 3
38 Trace Elements Phase 3
39 Vitamin B Complex Phase 3
40 Hematinics Phase 3
41 Folate Phase 3
42 Nutrients Phase 3
43 Vitamin B9 Phase 3
44
Acetaminophen Approved Phase 2 103-90-2 1983
45
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
46
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
47 Antipyretics Phase 2
48 Anesthetics, Local Phase 2
49 abobotulinumtoxinA Phase 1, Phase 2
50 Cholinergic Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 Does Sevoflurane Induce Genomic Instability in Patients Undergoing General Anaesthesia? Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
2 Opioid Free Anaesthesia vs Opioid Based Anesthesia in Cleft Lip, Palate ,Alveolus Surgery. Not yet recruiting NCT04081909 Phase 4 Fentanyl，Remifentanil;Ketamine,Dexmedetomidine
3 Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical Trial Not yet recruiting NCT04234971 Phase 4 Intervention group (DBM/BMP);Control group(autologous ICBG)
4 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Completed NCT03766217 Phase 3
5 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
6 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
7 Clinical Evaluation of Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
8 Velopharyngeal Function for Speech After Palatal Surgery Completed NCT00004639 Phase 2
9 Distraction Versus Orthognathic Surgery - Which One is Better for Cleft Palate Patients Completed NCT00930124 Phase 2
10 Evaluation of Postoperative Analgesic Effects of Bilateral Suprazygomatic Maxillary Nerve Block Using Bupivacaine and Dexmedetomidine in Children Undergoing Cleft Palate Repair Under General Anesthesia:Randomized Controlled Trial Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
11 Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
12 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489
13 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
14 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate: A Cross Sectional Study Unknown status NCT03219021
15 Osteogenesis and Dental Eruption Through Electrical Stimuli Following Periosteoplasty for Alveolar Clefts in Patients With Cleft Lip and Palate Deformities. A Preliminary Report. Unknown status NCT00975208
16 Distribution Of ABO Blood Groups In Relation To Cleft Lip And/or Palate . Unknown status NCT03217890
17 Stability of One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy: A Prospective Study Unknown status NCT01871623
18 Improving Outcomes in Cleft Palate Surgery Through an Audit and Feedback Intervention Directed at Surgeons Unknown status NCT02583100
19 Follow Ups of Parents With Infants With Cleft Lip and Palate Unknown status NCT02415361
20 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014
21 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
22 The Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Between Patients With and Without Pre-Alveolar Bone Graft Orthodontic Treatment Unknown status NCT02454998
23 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
24 Unilateral Cleft Repair in One Surgery With Pure Primary Healing Completed NCT04108416
25 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Completed NCT02881606
26 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Pain-related Temporomandibular Disorders Completed NCT03308266
27 Ultrasound Diagnosis of Cleft Lip and Palate - FENCHU Completed NCT03582111
28 Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients Completed NCT03686761
29 Emergence Delirium and Recovery Profile in Patients Undergoing Cleft Lip and Palate Repair: Comparison of Combination of Morphine and Fentanyl With Fentanyl Alone Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
30 Tympanometric Analysis in Post Surgical Individuals With Cleft Palate Completed NCT01820689
31 Efficacia Del Trattamento Chirurgico Maxillo-facciale Sul Volto Dei Bambini Con Labiopalatoschisi: Valutazioni Estetiche ed Ortodontiche Completed NCT03395015
32 Articulatory and Phonological Competence at 3 and 5 Years of Age in Children With Unilateral Cleft Lip and Palate Who Have Undergone Different Methods of Primary Palatal Surgery Completed NCT00829101
33 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients. A Prospective Randomized Trial Completed NCT02329509
34 Otologic and Rhinologic Outcomes in Children With Cleft Palate at Age 10 Years Completed NCT03708406
35 Effect of A Novel (Modified Grayson) Technique for Nasoalveolar Molding and Taping on Parents' Satisfaction and Short Term Treatment Outcomes in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Controlled Trial Completed NCT02845193
36 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
37 Clinical, Volumetric and Densitometric Evaluation of Tissue Engineered (TE) Constructs for Secondary Alveolar Cleft Reconstruction (Short Term Randomized Controlled Clinical Trial) Completed NCT03563495
38 Functional Outcomes of Cleft Lip and Lip Revision Surgery Completed NCT00070811
39 Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate Completed NCT03549039
40 Comparison Between Alveolar Bone Graft With Only Cancellous Bone, and Alveolar Bone Graft With Cancellous Bone Combined With Nasal Cavity Floor's Reconstruction Using a Cortical Block Completed NCT03883373
41 Palatal Lengthening Using Buccinator Myomucosal Flaps With Furlow Z-plasty Technique for Primary Cleft Palate Repair (A Clinical Study) Completed NCT04346173
42 OSAS in Children With Cleft Lip/Palate Completed NCT00156442
43 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
44 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
45 Comparison of Two Tooth-borne Expanders in Rapid Maxillary Expansion: Dentoalveolar Effects and Impact on Quality of Life Completed NCT03846518
46 Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion: A Case Series Completed NCT03976609
47 How Cerebral Oxygenation Correlates, Measured at Various Cranial Points, Frontally and Occipital in Children Under 1 Years Old, During General Anesthesia and Surgery Completed NCT03136952
48 Transversus Abdominis Plane Block Supplementation During Iliac Crest Bone Graft Harvest - Its Influence on Postoperative Parameters Completed NCT02997124
49 A Comparison of the Skeletal and Dento-alveolar Changes After Treatment of Class III Malocclusion With a Modified Tandem Appliance Versus the Face Mask Completed NCT02144324
50 Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate Context Recruiting NCT04049058

Search NIH Clinical Center for Cleft Lip/palate

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Genetic Tests for Cleft Lip/palate

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Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29
Sources

Anatomical Context for Cleft Lip/palate

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MalaCards organs/tissues related to Cleft Lip/palate:

40
Bone, Heart, Tongue, Lung, Skin, Eye, Testes
Sources

Publications for Cleft Lip/palate

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Articles related to Cleft Lip/palate:

(show top 50) (show all 7804)
# Title Authors PMID Year
1
Assisted breastfeeding technique to improve knowledge, attitude, and practices of mothers with cleft lip- and palate-affected infants: A randomized trial. 42 61
32388857 2020
2
Challenges in the Successful Reconstruction of Cleft Lip and Palate: Managing the Nasomaxillary Deformity in Adolescence. 42 61
32097323 2020
3
Psychological Variables in Children and Adolescents with Cleft Lip and/or Palate. 61 42
32271659 2020
4
Low incidence of maxillary hypoplasia in isolated cleft palate. 61
32206667 2020
5
The Effect of Nursing Care Provided to Turkish Mothers of Infants Born With Cleft Lip and Palate on Maternal Attachment and Self-efficacy: A Quasi-Experimental Study. 61
32139235 2020
6
Internationally Adopted Children With Unilateral Cleft Lip and Palate-Consonant Proficiency and Perceived Velopharyngeal Competence at the Age of 5. 61
31950849 2020
7
Incidence of Gastroesophageal Reflux Disease in Children With Cleft Lip and Palate and an Evaluation of Its Impact on Weight Gain. 61
32149845 2020
8
A task-shifted speech therapy program for cleft palate patients in rural Nepal: Evaluating impact and associated healthcare barriers. 61
32272376 2020
9
"I smile, but Without Showing My Teeth": The Lived Experience of Cleft, Lip, and Palate in Adults. 61
32351124 2020
10
Efficacy of Rapid Maxillary Expansion Associated With Maxillary Protraction in Patients With Unilateral Complete Cleft Lip and Palate. 61
31896277 2020
11
Evaluation of sphenoid sinus variations by using cone beam computed tomography in patients with cleft lip/palate. 61
31325089 2020
12
Emotional Well-Being in Adults Born With Cleft Lip and/or Palate: A Whole of Life Survey in the United Kingdom. 61
31906694 2020
13
Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level. 61
31900751 2020
14
Sacral protuberance with cleft lip and palate: Prenatal presentation of 3MC syndrome. 61
32441374 2020
15
Skeletofacial Reconstruction for Cleft-Related Deformities: Four Decades of Evolving Cleft Care. 61
31913899 2020
16
Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1. 61
32554531 2020
17
Prevalence and Clinical Case Series of Syndromic and Nonsyndromic Cleft Lip and Palate in a Saudi Arabian Neonatal Population. 61
32519557 2020
18
Oral health-related quality of life among young adults with cleft in northern Finland. 61
32396275 2020
19
Pregnancy Termination in the Case of an Orofacial Cleft: An Investigation of the Concept of Reproductive Autonomy. 61
32495649 2020
20
Quality of life in early age Spanish children treated for cleft lip and/or palate: a case-control study approach. 61
32556577 2020
21
Coverage, reporting degree and design of the Swedish quality registry for patients born with cleft lip and/or palate. 61
32522189 2020
22
Global Anesthesia in Oral and Maxillofacial Surgery. 61
32507355 2020
23
An Alternative Internal Le Fort I Distractor: Early Results With a New Trans-Nasal Device. 61
32118665 2020
24
The Economic Value of the Delivery of Primary Cleft Surgery in Timor Leste 2000-2017. 61
32030441 2020
25
Synchronous correction in secondary cleft deformities: a prospective cohort study. 61
32495610 2020
26
Global Nursing in Low-Resource and Middle-Resource Countries: Challenges and Opportunities in Perioperative Practice. 61
32507356 2020
27
How Is the Created Alveolar Space Finally Restored After Maxillary Anterior Segmental Distraction Osteogenesis? 61
32149967 2020
28
Simultaneous Midface Advancement and Orthognathic Surgery: A Powerful Technique for Managing Midface Hypoplasia and Malocclusion. 61
32459778 2020
29
Wharton's Jelly for Augmented Cleft Palate Repair in a Rat Critical-Size Alveolar Bone Defect Model. 61
31739755 2020
30
Cleft Palate Repair: Predictive Factors of Difficulty and Planned Strategies to Solve It. 61
32569044 2020
31
Minimally-invasive anterior maxillary distraction technique in patients with cleft lip and palate and maxillary deficiency: an evaluation of 106 patients. 61
32507641 2020
32
A meta-analysis and meta-regression of association between MTHFR A1298C polymorphism and nonsyndromic cleft lip/palate risk: An evaluation based on five genetic models. 61
32146124 2020
33
A Three-Dimensional Study of the Nasolabial Soft Tissue Symmetry in Children With Unilateral Complete Cleft Lip and Palate Using Traditional and Split-Type Nasoalveolar Molding. 61
32569046 2020
34
Evaluation of the Nasopharyngeal Cannula Use After Orthognathic Surgery: Permeability of the Nasal Airways and Discomfort of the Patient With Cleft Lip and Palate. 61
32502105 2020
35
Secondary Alveolar Bone Graft Using Recombinant Human Bone Morphogenetic Protein-2 (rh-BMP2) May Be as Efficacious as Autologous Grafting in Unilateral Cleft Lip and Palate Patients. 61
32473802 2020
36
Cone-Beam Computed Tomography Evaluation of the Eustachian Tube in Patients With Cleft Lip and Palate Compared With Normal Controls. 61
32149976 2020
37
Assessment of Treatment Outcome of Presurgical Nasoalveolar Molding in Patients With Cleft Lip and Palate and Its Postsurgical Stability. 61
32116001 2020
38
Reliability of Speech Variables and Speech-Related Quality Indicators in the Swedish Cleft Lip and Palate Registry. 61
31906706 2020
39
Does the Nostril Shape Change After Le Fort I Advancement in Patients With Unilateral Complete Cleft Lip? 61
32057693 2020
40
Neuropsychological functioning and its relationship with brain anatomical measures of children and adolescents with non-syndromic cleft lip and palate. 61
32546116 2020
41
Three-Dimensional Evaluation of Change in Maxillary Alveolar Arch after Expansion in Unilateral Cleft Lip and Palate Patients. 61
32522935 2020
42
Eustachian Tube Dysfunction in Children With Unilateral Cleft Lip and Palate: Differences Between Ipsilateral and Contralateral Ears. 61
31867994 2020
43
Comparison of 2- and 3-dimensional radiologic evaluation of secondary alveolar bone grafting of clefts: a systematic review. 61
32553577 2020
44
The Molecular Basis of Congenital Hypopituitarism and Related Disorders. 61
31702014 2020
45
Incidence of cleft-related speech problems in children with an isolated cleft lip. 61
32500400 2020
46
Survey on Condition and Orthodontic Treatment of Maxillary Lateral Incisors in Patients with Cleft Lip and Palate. 61
32522933 2020
47
Outcomes of bone morphogenetic protein-2 and iliac cancellous bone transplantation on alveolar cleft bone grafting: A meta-analysis. 61
32151557 2020
48
Occlusion at 5 Years of Age Following Hard Palate Closure With Vestibular Flap. 61
31847566 2020
49
Comparison of Microbial Activity Among Infants With or Without Using Presurgical Nasoalveolar Molding Appliance. 61
32253929 2020
50
Influence of different techniques of secondary cleft lip revision surgery on upper lip projection. 61
31699632 2020
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Variations for Cleft Lip/palate

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Expression for Cleft Lip/palate

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Search GEO for disease gene expression data for Cleft Lip/palate.
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Pathways for Cleft Lip/palate

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Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.06 TGFA FGFR1 DLG1 CDH1 BMP4
2
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.91 TGFA IRF6 FGFR1 BMP4
3
Hippo signaling pathway 36
11.75 YAP1 DLG1 CDH1 BMP4
4
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.58 TP63 MSX1 IRF6 BMP4
5
Adherens junction 36
11.35 NECTIN1 FGFR1 CDH1
6
Neural Crest Differentiation 1
11.27 MSX1 FGFR1 CDH1 BMP4
7
Hypothetical Craniofacial Development Pathway 1
9.7 TP63 IRF6 ARHGAP29
Sources

GO Terms for Cleft Lip/palate

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Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.05 TP63 MSX1 INTU FGFR1 DLX4 CDH1
2 positive regulation of transcription, DNA-templated GO:0045893 10.03 YAP1 TP63 IRF6 CDH1 BMP4
3 negative regulation of transcription by RNA polymerase II GO:0000122 10.03 TP63 MSX1 FGFR1 DLX4 DLG1 BMP4
4 positive regulation of cell proliferation GO:0008284 9.98 YAP1 TGFA FGFR1 DLG1 BMP4
5 negative regulation of gene expression GO:0010629 9.91 YAP1 WDR35 FGFR1 BMP4
6 cell morphogenesis GO:0000902 9.77 YAP1 MSX1 CDH1
7 roof of mouth development GO:0060021 9.7 MSX1 IRF6 INTU
8 positive regulation of epithelial cell proliferation GO:0050679 9.67 YAP1 TGFA BMP4
9 camera-type eye morphogenesis GO:0048593 9.64 NECTIN1 BMP4
10 embryonic morphogenesis GO:0048598 9.64 MSX1 BMP4
11 middle ear morphogenesis GO:0042474 9.63 MSX1 FGFR1
12 embryonic digit morphogenesis GO:0042733 9.63 MSX1 INTU BMP4
13 anatomical structure formation involved in morphogenesis GO:0048646 9.62 TP63 BMP4
14 embryo development GO:0009790 9.62 DLX4 DLG1
15 establishment of planar polarity GO:0001736 9.61 TP63 INTU
16 odontogenesis of dentin-containing tooth GO:0042475 9.61 TP63 MSX1 BMP4
17 smooth muscle tissue development GO:0048745 9.59 DLG1 BMP4
18 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.58 MSX1 BMP4
19 organ induction GO:0001759 9.57 FGFR1 BMP4
20 paraxial mesoderm development GO:0048339 9.55 YAP1 FGFR1
21 astral microtubule organization GO:0030953 9.54 DLG1 CEP120
22 ureteric bud development GO:0001657 9.54 FGFR1 DLG1 BMP4
23 bud elongation involved in lung branching GO:0060449 9.48 YAP1 BMP4
24 pituitary gland development GO:0021983 9.43 MSX1 CDH1 BMP4
25 BMP signaling pathway involved in heart development GO:0061312 9.4 MSX1 BMP4
26 embryonic hindlimb morphogenesis GO:0035116 9.33 TP63 MSX1 BMP4
27 cloacal septation GO:0060197 9.32 TP63 BMP4
28 embryonic limb morphogenesis GO:0030326 9.26 TP63 MSX1 FGFR1 BMP4
29 keratinocyte differentiation GO:0030216 8.92 YAP1 TP63 IRF6 INTU
Sources

Sources for Cleft Lip/palate

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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