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FLP
MCID: CLF004
MIFTS: 56

Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cleft Lip/palate

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MalaCards integrated aliases for Cleft Lip/palate:

Name: Cleft Lip/palate 60 30
Cleft Lip and Palate 60 44
Cleft Lip-Alveolus-Palate Syndrome 60
Alveolar Cleft Lip and Palate 60
Flp 60

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Developmental anomalies during embryogenesis


External Ids:

UMLS via Orphanet 75 C0158646
Orphanet 60 ORPHA199306
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Summaries for Cleft Lip/palate

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MedlinePlus : 44 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 7 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Hippo signaling pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Coagulants and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and testes, and related phenotypes are embryo and growth/size/body region

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Related Diseases for Cleft Lip/palate

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Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 312)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 34.9 EEC1 TP63
2 short-rib thoracic dysplasia 7 with or without polydactyly 32.8 INTU WDR35
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.5 TTC21B WDR35 WDR60
4 bartsocas-papas syndrome 32.3 IRF6 TP63
5 short-rib thoracic dysplasia 1 with or without polydactyly 32.0 TTC21B WDR35 WDR60
6 cleft lip and alveolus 31.2 IRF6 MSX1 NECTIN1 TP63
7 isolated cleft lip 30.9 IRF6 MSX1 NECTIN1 TP63
8 tooth size 30.6 BMP4 MSX1
9 cleft lip 30.5 ARHGAP29 BMP4 CDH1 DLX4 FGFR1 IRF6
10 tooth agenesis 29.8 BMP4 CDH1 FGFR1 IRF6 MSX1
11 cleft palate, isolated 29.8 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
12 ankyloblepharon-ectodermal defects-cleft lip/palate 12.9
13 cleft lip/palate-ectodermal dysplasia syndrome 12.9
14 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.8
15 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.8
16 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.7
17 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.6
18 tibial hemimelia cleft lip palate 12.5
19 cleft lip/palate with abnormal thumbs and microcephaly 12.5
20 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.5
21 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.4
22 radius, aplasia of, with cleft lip/palate 12.4
23 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.4
24 cleft lip palate dysmorphism kumar type 12.4
25 cleft lip palate oligodontia syndactyly pili torti 12.4
26 cleft lip palate pituitary deficiency 12.4
27 cleft lip palate-tetraphocomelia 12.4
28 craniosynostosis cleft lip palate arthrogryposis 12.4
29 holoprosencephaly ectrodactyly cleft lip palate 12.4
30 lagophthalmia cleft lip palate 12.4
31 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.4
32 cleft lip/palate-deafness-sacral lipoma syndrome 12.4
33 cleft lip and palate malrotation cardiopathy 12.3
34 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.3
35 popliteal pterygium syndrome 12.2
36 hartsfield syndrome 12.2
37 cleft palate, cardiac defects, and mental retardation 12.2
38 rapp-hodgkin syndrome 12.2
39 blepharocheilodontic syndrome 1 12.2
40 vici syndrome 12.1
41 richieri-costa/guion-almeida syndrome 12.1
42 acrofrontofacionasal dysostosis 12.1
43 pilotto syndrome 12.0
44 zlotogora syndrome 12.0
45 orofacial cleft 1 11.9
46 uveal coloboma-cleft lip and palate-intellectual disability 11.8
47 orofaciodigital syndrome vi 11.8
48 martinez monasterio pinheiro syndrome 11.7
49 samson viljoen syndrome 11.6
50 kapur-toriello syndrome 11.6

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate
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Symptoms & Phenotypes for Cleft Lip/palate

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MGI Mouse Phenotypes related to Cleft Lip/palate:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.44 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
2 growth/size/body region MP:0005378 10.4 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
3 cellular MP:0005384 10.35 BMP4 CDH1 DLG1 FGFR1 INTU IRF6
4 craniofacial MP:0005382 10.34 ARHGAP29 BMP4 DLG1 FGFR1 IRF6 MEIS2
5 mortality/aging MP:0010768 10.34 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
6 digestive/alimentary MP:0005381 10.33 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 IRF6
7 cardiovascular system MP:0005385 10.27 BMP4 CDH1 FGFR1 INTU MEIS2 MSX1
8 homeostasis/metabolism MP:0005376 10.27 BMP4 CDH1 DLG1 FGFR1 INTU MSX1
9 limbs/digits/tail MP:0005371 10.16 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
10 integument MP:0010771 10.13 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
11 nervous system MP:0003631 10.07 BMP4 DLG1 FGFR1 INTU MEIS2 MID1
12 muscle MP:0005369 10.01 BMP4 DLG1 FGFR1 MID1 MSX1 TP63
13 hearing/vestibular/ear MP:0005377 9.99 BMP4 FGFR1 IRF6 MEIS2 MSX1 RSPO2
14 no phenotypic analysis MP:0003012 9.87 BMP4 CDH1 DLG1 FGFR1 RSPO2 TP63
15 renal/urinary system MP:0005367 9.86 BMP4 DLG1 FGFR1 INTU RSPO2 TP63
16 skeleton MP:0005390 9.73 BMP4 DLG1 FGFR1 INTU IRF6 MEIS2
17 respiratory system MP:0005388 9.7 BMP4 DLG1 MSX1 RSPO2 TP63 WDR35
18 vision/eye MP:0005391 9.23 BMP4 DLG1 FGFR1 INTU MEIS2 MSX1
Sources

Drugs & Therapeutics for Cleft Lip/palate

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Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Coagulants Phase 4
2 Fibrin Tissue Adhesive Phase 4
3 Hemostatics Phase 4
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Micronutrients Phase 3
7 Vitamin B9 Phase 3
8 Folate Phase 3
9 Hematinics Phase 3
10 Nutrients Phase 3
11 Vitamin B Complex Phase 3
12 Trace Elements Phase 3
13 Vitamins Phase 3
14
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
15
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
16
Acetaminophen Approved Phase 2 103-90-2 1983
17
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
18 Anesthetics Phase 2,Not Applicable
19 Hypnotics and Sedatives Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Adrenergic alpha-Agonists Phase 2
22 Adrenergic Agents Phase 2
23 Analgesics Phase 2,Not Applicable
24 Central Nervous System Depressants Phase 2,Not Applicable
25 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable
26 Adrenergic Agonists Phase 2
27 Adrenergic alpha-2 Receptor Agonists Phase 2
28 Antipyretics Phase 2
29 Neurotransmitter Agents Phase 2,Phase 1
30 Anesthetics, Local Phase 2,Not Applicable
31 Acetylcholine Release Inhibitors Phase 1, Phase 2
32 Cholinergic Agents Phase 1, Phase 2
33 Botulinum Toxins Phase 1, Phase 2
34 abobotulinumtoxinA Phase 1, Phase 2
35 Neuromuscular Agents Phase 1, Phase 2
36 Botulinum Toxins, Type A Phase 1, Phase 2
37
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
38
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
39
Methylene blue Approved, Investigational Not Applicable 61-73-4
40
Racepinephrine Approved Not Applicable 329-65-7 838
41
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
42 Narcotics Not Applicable
43 Anesthetics, Intravenous Not Applicable
44 Analgesics, Opioid Not Applicable
45 Adjuvants, Anesthesia Not Applicable
46 Anesthetics, General Not Applicable
47 Pharmaceutical Solutions Not Applicable
48 Epinephryl borate Not Applicable
49 Daminozide Not Applicable 1596-84-5

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
6 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
7 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
8 Suprazygomatic Block in Cleft Palate Surgery in Children Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
10 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489 Not Applicable
11 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
12 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
13 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
14 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
15 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
16 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014 Not Applicable
17 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
18 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
19 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
20 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
21 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
22 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
23 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
24 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
25 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
26 Periodontal Changes Following Mid Maxillary Distraction Completed NCT03686761 Not Applicable
27 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
28 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
29 Effect of Alveolar Bone Grafting Completed NCT03549039
30 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
31 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
32 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
33 Alveolar Bone Graft Cortical Nasal Floor Completed NCT03883373
34 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
35 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
36 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
37 Child and Infant Learning Project Completed NCT00077831
38 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
39 Three Dimensional Facial Growth Analysis Recruiting NCT03514563
40 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606 Not Applicable
41 Otologic and Rhinologic Outcomes in Children With Clef Palate Recruiting NCT03708406
42 Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty Recruiting NCT03839290
43 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686 Not Applicable
44 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
45 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
46 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
47 Targeting Surgeons' Decision-Making for Cleft Lip Surgery Recruiting NCT03537976 Not Applicable
48 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Active, not recruiting NCT03029195 Not Applicable
49 Effect of Novel Nasoalveolar Molding Techniques on Parents' Satisfaction and Short Term Treatment Outcomes in Unilateral Cleft Lip and Palate Infants: A Randomized Controlled Trial Active, not recruiting NCT02845193 Not Applicable
50 Follow Ups of Parents With Infants With Cleft Lip and Palate Active, not recruiting NCT02415361 Not Applicable

Search NIH Clinical Center for Cleft Lip/palate

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Genetic Tests for Cleft Lip/palate

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Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 30
Sources

Anatomical Context for Cleft Lip/palate

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MalaCards organs/tissues related to Cleft Lip/palate:

42
Bone, Heart, Testes, Tongue, Eye, Breast, Skin
Sources

Publications for Cleft Lip/palate

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Articles related to Cleft Lip/palate:

(show top 50) (show all 3378)
# Title Authors Year
1
Performing together: Monozygotic twin comedians/Twin research: Mirror-image cleft lip and palate; dental caries; noninvasive prenatal testing; Capgras syndrome with folie à Deux/In the news: athletic twins; transgendered twins; crib-sharing; common careers. ( 30739630 )
2019
2
The effect of facial expression on facial symmetry in surgically managed unilateral cleft lip and palate patients (UCLP). ( 30522896 )
2019
3
Child development skills and language in toddlers with cleft lip and palate. ( 30554694 )
2019
4
Polymorphism of reduced folate carrier 1 (A80G) and non-syndromic cleft lip/palate: A systematic review and meta-analysis. ( 30579244 )
2019
5
Three-dimensional analyses of nasolabial forms and upper lip surface symmetry after primary lip repair in patients with complete unilateral cleft lip and palate. ( 30600197 )
2019
6
Reliability of Americleft Yardstick Nasolabial Appearance Assessment With/Without Basal View for Japanese Children With Unilateral Complete Cleft Lip and Palate. ( 30602307 )
2019
7
Long-term stability after multidisciplinary treatment involving maxillary distraction osteogenesis, and sagittal split ramus osteotomy for unilateral cleft lip and palate with severe occlusal collapse and gingival recession: A case report. ( 30603626 )
2019
8
Molar-Incisor Hypomineralization and Cleft Lip and Palate. ( 30628943 )
2019
9
Blood loss and operative time associated with orthognathic surgery utilizing a novel navigation system in cleft lip and palate patients. ( 30630700 )
2019
10
Usefulness of Airway Scope for intubation of infants with cleft lip and palate-comparison with Macintosh laryngoscope: a randomized controlled trial. ( 30636639 )
2019
11
Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate. ( 30638414 )
2019
12
A Cleft Lip and Palate Gene, Irf6, is Involved in Osteoblast Differentiation of Craniofacial Bone. ( 30684382 )
2019
13
Eighteen-Year Follow-Up of 160 Consecutive Individuals Born With Unilateral Cleft Lip or Cleft Lip and Alveolus Treated by the Oslo Cleft Lip and Palate Team. ( 30686058 )
2019
14
Study on Tooth Movement After the Alveolar Bone Grafting in Patients With Unilateral Cleft Lip and Palate. ( 30688812 )
2019
15
Prognostic Factors for Hearing Outcomes in Children with Cleft Lip and Palate. ( 30688899 )
2019
16
Upper Airway Features of Unilateral Cleft Lip and Palate Patients in Different Growth Stages. ( 30694706 )
2019
17
Imaging study of midface growth with bone-borne trans-sutural distraction osteogenesis therapy in growing cleft lip and palate patients. ( 30696887 )
2019
18
A qualitative study of children's quality of life in the context of living with cleft lip and palate. ( 30697094 )
2019
19
Are there any solutions for improving the cleft area hygiene in patients with cleft lip and palate? A systematic review. ( 30697916 )
2019
20
Impacted maxillary canine in unilateral cleft lip and palate: A literature review. ( 30705572 )
2019
21
Dental management of a child with ectrodactyly ectodermal dysplasia cleft lip/palate syndrome: A case report. ( 30720215 )
2019
22
Prevalence of Hypodontia in Unilateral and Bilateral Cleft Lip and Palate Patients Inside and Outside Cleft Area: A Case-Control Study. ( 30730800 )
2019
23
Current methods for secondary alveolar bone grafting assessment in cleft lip and palate patients - A systematic review. ( 30733132 )
2019
24
Craniofacial morphology and soft tissue profile outcomes for complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30735011 )
2019
25
Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis. ( 30740615 )
2019
26
Dental arch relationship outcomes for children with complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30742737 )
2019
27
Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals. ( 30815431 )
2019
28
Reply: Outpatient versus Inpatient Primary Cleft Lip and Palate Surgery: Analysis of Early Complications. ( 30817672 )
2019
29
The Relationship between the Type of Cleft and Nasal Air Emission in Speech of Children with Cleft Palate or Cleft Lip and Palate. ( 30834000 )
2019
30
A Simple Technique to Repair a Residual Oronasal Fistula in Bilateral Cleft Lip and Palate Patients. ( 30836074 )
2019
31
Extension and validation of the protocol of orofacial myofunctional assessment for individuals with cleft lip and palate. ( 30843925 )
2019
32
Do Cleft Lip and Palate Types Affect Health-Related Quality of Life of Adolescents? ( 30845087 )
2019
33
Breaking Symmetry: A Quantitative Analysis of Facial Skeleton Disharmony in Children Born with Bilateral Cleft Lip and Palate. ( 30851147 )
2019
34
Orthognathic Surgery for Patients with Cleft Lip and Palate. ( 30851748 )
2019
35
Intraoral Digital Impression Technique for a Neonate With Bilateral Cleft Lip and Palate. ( 30857398 )
2019
36
Bone-anchored maxillary protraction in unilateral cleft lip and palate: a cephalometric appraisal. ( 30865780 )
2019
37
Three-Dimensional Assessment of Morphological Changes Following Nasoalveolar Molding Therapy in Cleft Lip and Palate Patients: A Case Report. ( 30866516 )
2019
38
A Pristine Approach for the Prominent Premaxilla in Bilateral Cleft Lip and Palate (BCLP) Cases. ( 30866673 )
2019
39
The absolute and relative effects of presurgical nasoalveolar moulding in bilateral cleft lip and palate patients compared with nasal growth in healthy newborns. ( 30878462 )
2019
40
Effect on Facial Growth of the Management of Cleft Lip and Palate. ( 30882417 )
2019
41
Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients. ( 30906959 )
2019
42
Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics. ( 30912603 )
2019
43
Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study. ( 30913937 )
2019
44
Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind, randomised study. ( 30308523 )
2019
45
Secondary alveolar bone grafting in cleft lip and palate: A comparative analysis of donor site morbidity in different age groups. ( 30527380 )
2019
46
Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Year Follow-Up of a Treatment Protocol. ( 30531628 )
2019
47
Novel 3-D Analysis for the Assessment of Cleft Dimensions on Digital Models of Infants With Unilateral Cleft Lip and Palate. ( 29652538 )
2019
48
Reliability of a Categorical Scale (GOSLON) and a Continuous Scale (10-cm Visual Analog Scale) for Assessing Dental Arch Relationships Using Conventional Plaster and 3D Digital Orthodontic Study Models of Children With Complete Unilateral Cleft Lip and Palate. ( 29698112 )
2019
49
Nasal Obstruction in Children With Cleft Lip and Palate: Results of a Cross-Sectional Study Utilizing the NOSE Scale. ( 29698113 )
2019
50
Three-Dimensional Soft Tissue Nasal Changes After Nasoalveolar Molding and Primary Cheilorhinoplasty in Infants With Unilateral Cleft Lip and Palate. ( 29698115 )
2019
Sources

Variations for Cleft Lip/palate

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Expression for Cleft Lip/palate

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Search GEO for disease gene expression data for Cleft Lip/palate.
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Pathways for Cleft Lip/palate

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Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hippo signaling pathway 38
11.81 BMP4 CDH1 DLG1 YAP1
2
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.58 BMP4 IRF6 MSX1 TP63
3
Adherens junction 38
11.4 CDH1 FGFR1 NECTIN1
4
Neural Crest Differentiation 1
11.27 BMP4 CDH1 FGFR1 MSX1
5
Intraflagellar transport 67
11.05 TTC21B WDR35 WDR60
6
Hypothetical Craniofacial Development Pathway 1
9.7 ARHGAP29 IRF6 TP63
Sources

GO Terms for Cleft Lip/palate

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Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 9.16 CDH1 NECTIN1
2 intraciliary transport particle A GO:0030991 8.96 TTC21B WDR35
3 ciliary tip GO:0097542 8.8 TTC21B WDR35 WDR60

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.87 BMP4 DLG1 DLX4 FGFR1 MEIS2 MSX1
2 embryonic digit morphogenesis GO:0042733 9.7 BMP4 INTU MSX1
3 odontogenesis of dentin-containing tooth GO:0042475 9.69 BMP4 MSX1 TP63
4 embryonic skeletal system morphogenesis GO:0048704 9.65 BMP4 DLG1 WDR60
5 ureteric bud development GO:0001657 9.63 BMP4 DLG1 FGFR1
6 anatomical structure formation involved in morphogenesis GO:0048646 9.62 BMP4 TP63
7 camera-type eye morphogenesis GO:0048593 9.62 BMP4 NECTIN1
8 middle ear morphogenesis GO:0042474 9.61 FGFR1 MSX1
9 intraciliary transport involved in cilium assembly GO:0035735 9.61 TTC21B WDR35 WDR60
10 epithelial tube branching involved in lung morphogenesis GO:0060441 9.6 BMP4 RSPO2
11 establishment of planar polarity GO:0001736 9.59 INTU TP63
12 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.58 BMP4 MSX1
13 intraciliary retrograde transport GO:0035721 9.58 TTC21B WDR35
14 organ induction GO:0001759 9.57 BMP4 FGFR1
15 smooth muscle tissue development GO:0048745 9.56 BMP4 DLG1
16 paraxial mesoderm development GO:0048339 9.55 FGFR1 YAP1
17 bud elongation involved in lung branching GO:0060449 9.54 BMP4 YAP1
18 embryonic forelimb morphogenesis GO:0035115 9.54 MSX1 RSPO2 TP63
19 BMP signaling pathway involved in heart development GO:0061312 9.49 BMP4 MSX1
20 keratinocyte differentiation GO:0030216 9.46 INTU IRF6 TP63 YAP1
21 pituitary gland development GO:0021983 9.43 BMP4 CDH1 MSX1
22 cloacal septation GO:0060197 9.4 BMP4 TP63
23 embryonic limb morphogenesis GO:0030326 9.26 BMP4 FGFR1 MSX1 TP63
24 embryonic hindlimb morphogenesis GO:0035116 8.92 BMP4 MSX1 RSPO2 TP63
25 positive regulation of transcription, DNA-templated GO:0045893 10 BMP4 CDH1 IRF6 TP63 YAP1

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 DLX4 IRF6 MEIS2 MSX1 TP63
Sources

Sources for Cleft Lip/palate

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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