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MCID: CLF004
MIFTS: 56

Cleft Lip/palate

Categories: Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Cleft Lip/palate

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MalaCards integrated aliases for Cleft Lip/palate:

Name: Cleft Lip/palate 60 30
Cleft Lip and Palate 60 44
Cleft Lip-Alveolus-Palate Syndrome 60
Alveolar Cleft Lip and Palate 60
Flp 60

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 35
Orphanet: 60  
Developmental anomalies during embryogenesis


External Ids:

UMLS via Orphanet 75 C0158646
Orphanet 60 ORPHA199306
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Summaries for Cleft Lip/palate

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MedlinePlus : 44 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 7 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Organelle biogenesis and maintenance and Mesodermal Commitment Pathway. The drugs Fibrin Tissue Adhesive and Hemostatics have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and tongue, and related phenotypes are embryo and cellular

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Related Diseases for Cleft Lip/palate

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Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 331)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 34.6 EEC1 TP63
2 short-rib thoracic dysplasia 7 with or without polydactyly 32.7 INTU WDR35
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.4 TCTEX1D2 WDR19 WDR34 WDR35 WDR60
4 bartsocas-papas syndrome 32.2 IRF6 TP63
5 short-rib thoracic dysplasia 1 with or without polydactyly 32.2 WDR19 WDR34 WDR35 WDR60
6 cleft lip and alveolus 31.1 IRF6 MSX1 NECTIN1 TP63
7 isolated cleft lip 31.0 IRF6 MSX1 NECTIN1 TP63
8 polydactyly 30.6 TCTEX1D2 WDR34 WDR35 WDR60
9 cleft lip 30.5 ARHGAP29 BMP4 CDH1 DLX4 FGFR1 IRF6
10 tooth size 30.5 BMP4 MSX1
11 tooth agenesis 30.2 BMP4 CDH1 FGFR1 IRF6 MSX1
12 cleft palate, isolated 29.7 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
13 ankyloblepharon-ectodermal defects-cleft lip/palate 12.9
14 cleft lip/palate-ectodermal dysplasia syndrome 12.9
15 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.9
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.8
17 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.8
18 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.6
19 tibial hemimelia cleft lip palate 12.5
20 cleft lip/palate with abnormal thumbs and microcephaly 12.5
21 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.5
22 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.5
23 radius, aplasia of, with cleft lip/palate 12.4
24 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.4
25 cleft lip palate dysmorphism kumar type 12.4
26 cleft lip palate oligodontia syndactyly pili torti 12.4
27 cleft lip palate pituitary deficiency 12.4
28 cleft lip palate-tetraphocomelia 12.4
29 craniosynostosis cleft lip palate arthrogryposis 12.4
30 holoprosencephaly ectrodactyly cleft lip palate 12.4
31 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.4
32 cleft lip/palate-deafness-sacral lipoma syndrome 12.4
33 cleft lip and palate malrotation cardiopathy 12.4
34 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.4
35 popliteal pterygium syndrome 12.3
36 hartsfield syndrome 12.2
37 cleft palate, cardiac defects, and mental retardation 12.2
38 rapp-hodgkin syndrome 12.2
39 blepharocheilodontic syndrome 1 12.2
40 vici syndrome 12.2
41 richieri-costa/guion-almeida syndrome 12.1
42 acrofrontofacionasal dysostosis 12.1
43 pilotto syndrome 12.0
44 zlotogora syndrome 12.0
45 orofacial cleft 1 11.9
46 uveal coloboma-cleft lip and palate-intellectual disability 11.9
47 orofaciodigital syndrome vi 11.8
48 fryns microphthalmia syndrome 11.7
49 martinez monasterio pinheiro syndrome 11.7
50 samson viljoen syndrome 11.7

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate
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Symptoms & Phenotypes for Cleft Lip/palate

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MGI Mouse Phenotypes related to Cleft Lip/palate:

47 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.28 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
2 cellular MP:0005384 10.27 BMP4 CDH1 DLG1 FGFR1 INTU IRF6
3 growth/size/body region MP:0005378 10.22 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
4 digestive/alimentary MP:0005381 10.2 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 IRF6
5 craniofacial MP:0005382 10.18 ARHGAP29 BMP4 DLG1 FGFR1 IRF6 MSX1
6 mortality/aging MP:0010768 10.13 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
7 limbs/digits/tail MP:0005371 10.02 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
8 integument MP:0010771 9.97 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
9 muscle MP:0005369 9.76 BMP4 DLG1 FGFR1 MSX1 TP63 WDR19
10 skeleton MP:0005390 9.65 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
11 vision/eye MP:0005391 9.23 BMP4 DLG1 FGFR1 INTU MSX1 NECTIN1
Sources

Drugs & Therapeutics for Cleft Lip/palate

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Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrin Tissue Adhesive Phase 4
2 Hemostatics Phase 4
3 Coagulants Phase 4
4
leucovorin Approved Phase 3 58-05-9 143 6006
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Vitamin B9 Phase 3
7 Folate Phase 3
8 Vitamins Phase 3
9 Hematinics Phase 3
10 Micronutrients Phase 3
11 Nutrients Phase 3
12 Trace Elements Phase 3
13 Vitamin B Complex Phase 3
14
Acetaminophen Approved Phase 2 103-90-2 1983
15
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 5311068 68602
16
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
17
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
18 Anesthetics Phase 2,Not Applicable
19 Analgesics Phase 2,Not Applicable
20 Hypnotics and Sedatives Phase 2
21 Adrenergic alpha-Agonists Phase 2
22 Central Nervous System Depressants Phase 2,Not Applicable
23 Adrenergic Agonists Phase 2
24 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable
25 Adrenergic Agents Phase 2
26 Neurotransmitter Agents Phase 2,Phase 1
27 Analgesics, Non-Narcotic Phase 2
28 Anesthetics, Local Phase 2,Not Applicable
29 Adrenergic alpha-2 Receptor Agonists Phase 2
30 Antipyretics Phase 2
31 abobotulinumtoxinA Phase 1, Phase 2
32 Botulinum Toxins Phase 1, Phase 2
33 Acetylcholine Release Inhibitors Phase 1, Phase 2
34 Neuromuscular Agents Phase 1, Phase 2
35 Botulinum Toxins, Type A Phase 1, Phase 2
36 Cholinergic Agents Phase 1, Phase 2
37
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
39
Methylene blue Approved, Investigational Not Applicable 61-73-4
40
Racepinephrine Approved Not Applicable 329-65-7 838
41
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
42 Anesthetics, General Not Applicable
43 Anesthetics, Intravenous Not Applicable
44 Adjuvants, Anesthesia Not Applicable
45 Analgesics, Opioid Not Applicable
46 Narcotics Not Applicable
47 Pharmaceutical Solutions Not Applicable
48 Epinephryl borate Not Applicable
49 Daminozide Not Applicable 1596-84-5

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
6 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
7 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
8 Suprazygomatic Block in Cleft Palate Surgery in Children Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
10 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489 Not Applicable
11 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
12 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
13 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
14 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
15 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
16 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014 Not Applicable
17 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
18 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
19 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
20 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
21 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
22 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
23 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
24 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
25 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
26 Periodontal Changes Following Mid Maxillary Distraction Completed NCT03686761 Not Applicable
27 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
28 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
29 Effect of Alveolar Bone Grafting Completed NCT03549039
30 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
31 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
32 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
33 Alveolar Bone Graft Cortical Nasal Floor Completed NCT03883373
34 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
35 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
36 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
37 Child and Infant Learning Project Completed NCT00077831
38 Three Dimensional Facial Growth Analysis Recruiting NCT03514563
39 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606 Not Applicable
40 Otologic and Rhinologic Outcomes in Children With Clef Palate Recruiting NCT03708406
41 Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty Recruiting NCT03839290
42 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686 Not Applicable
43 Clinical Assessment of Usage of Cleft Margin Flap With Anterior Palatal Closure in Closure of Naso-alveolar Defect. Recruiting NCT03922438 Not Applicable
44 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
45 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
46 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
47 Targeting Surgeons' Decision-Making for Cleft Lip Surgery Recruiting NCT03537976 Not Applicable
48 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Active, not recruiting NCT02789787
49 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Active, not recruiting NCT03029195 Not Applicable
50 Effect of Novel Nasoalveolar Molding Techniques on Parents' Satisfaction and Short Term Treatment Outcomes in Unilateral Cleft Lip and Palate Infants: A Randomized Controlled Trial Active, not recruiting NCT02845193 Not Applicable

Search NIH Clinical Center for Cleft Lip/palate

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Genetic Tests for Cleft Lip/palate

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Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 30
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Anatomical Context for Cleft Lip/palate

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MalaCards organs/tissues related to Cleft Lip/palate:

42
Bone, Heart, Tongue, Breast, Skin, Kidney, Testes
Sources

Publications for Cleft Lip/palate

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Articles related to Cleft Lip/palate:

(show top 50) (show all 3407)
# Title Authors Year
1
Performing Together: Monozygotic Twin Comedians/Twin research: Mirror-Image Cleft Lip and Palate; Dental Caries; Noninvasive Prenatal testing; Capgras Syndrome with Folie à Deux/In the News: Athletic Twins; Transgendered Twins; Crib-Sharing; Common Careers. ( 30739630 )
2019
2
Impacted maxillary canine in unilateral cleft lip and palate: A literature review. ( 30705572 )
2019
3
Dental management of a child with ectrodactyly ectodermal dysplasia cleft lip/palate syndrome: A case report. ( 30720215 )
2019
4
Prevalence of Hypodontia in Unilateral and Bilateral Cleft Lip and Palate Patients Inside and Outside Cleft Area: A Case-Control Study. ( 30730800 )
2019
5
Current methods for secondary alveolar bone grafting assessment in cleft lip and palate patients - A systematic review. ( 30733132 )
2019
6
Craniofacial morphology and soft tissue profile outcomes for complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30735011 )
2019
7
Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients: systematic review and meta-analysis. ( 30740615 )
2019
8
Dental arch relationship outcomes for children with complete unilateral and complete bilateral cleft lip and palate in New Zealand. ( 30742737 )
2019
9
Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals. ( 30815431 )
2019
10
Reply: Outpatient versus Inpatient Primary Cleft Lip and Palate Surgery: Analysis of Early Complications. ( 30817672 )
2019
11
The Relationship between the Type of Cleft and Nasal Air Emission in Speech of Children with Cleft Palate or Cleft Lip and Palate. ( 30834000 )
2019
12
A Simple Technique to Repair a Residual Oronasal Fistula in Bilateral Cleft Lip and Palate Patients. ( 30836074 )
2019
13
Extension and validation of the protocol of orofacial myofunctional assessment for individuals with cleft lip and palate. ( 30843925 )
2019
14
Do Cleft Lip and Palate Types Affect Health-Related Quality of Life of Adolescents? ( 30845087 )
2019
15
Breaking Symmetry: A Quantitative Analysis of Facial Skeleton Disharmony in Children Born with Bilateral Cleft Lip and Palate. ( 30851147 )
2019
16
Orthognathic Surgery for Patients with Cleft Lip and Palate. ( 30851748 )
2019
17
Intraoral Digital Impression Technique for a Neonate With Bilateral Cleft Lip and Palate. ( 30857398 )
2019
18
Bone-anchored maxillary protraction in unilateral cleft lip and palate: a cephalometric appraisal. ( 30865780 )
2019
19
Three-Dimensional Assessment of Morphological Changes Following Nasoalveolar Molding Therapy in Cleft Lip and Palate Patients: A Case Report. ( 30866516 )
2019
20
A Pristine Approach for the Prominent Premaxilla in Bilateral Cleft Lip and Palate (BCLP) Cases. ( 30866673 )
2019
21
The absolute and relative effects of presurgical nasoalveolar moulding in bilateral cleft lip and palate patients compared with nasal growth in healthy newborns. ( 30878462 )
2019
22
Effect on Facial Growth of the Management of Cleft Lip and Palate. ( 30882417 )
2019
23
Functional dysbiosis within dental plaque microbiota in cleft lip and palate patients. ( 30906959 )
2019
24
Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics. ( 30912603 )
2019
25
Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study. ( 30913937 )
2019
26
Influence of vomer flap on craniofacial growth in patients with cleft lip and palate: A systematic review. ( 30935851 )
2019
27
Midface Growth in Patients With Unilateral Cleft Lip and Palate Treated With a Nasoalveolar Molding Protocol. ( 30950956 )
2019
28
Preoperative nasoalveolar moulding in a patient with a unilateral cleft lip and palate using a modified nostril retainer: a technical note. ( 30987749 )
2019
29
Complications Following Orthognathic Surgery for Patients With Cleft Lip/Palate. ( 30998594 )
2019
30
"The influence of four different treatment protocols on maxillofacial growth in patients with unilateral complete cleft lip, palate, and alveolus". ( 30998658 )
2019
31
Oral habits in Children with Cleft (Lip and) Palate: A Pilot Study. ( 30999309 )
2019
32
Tongue-palate contact patterns for Japanese speakers with and without cleft lip and palate. ( 31014123 )
2019
33
Quality of Life and Patient Satisfaction in Adults Treated for a Cleft Lip and Palate: A Qualitative Analysis. ( 31018676 )
2019
34
The Electrical Activity of Masseter and Anterior Temporal Muscles in Patients with Unilateral Cleft Lip and Palate. ( 31022137 )
2019
35
Evaluation of the Facial Soft-Tissue Thickness in Patients With Cleft Lip and Palate. ( 31033758 )
2019
36
Correlation between quality of life and burden of family caregivers of infants with cleft lip and palate. ( 31038544 )
2019
37
Columella Elongation Surgery Outcome in Complete Bilateral Cleft Lip and Palate. ( 31044118 )
2019
38
Autologous Fat Grafting in Cleft Lip and Palate. ( 31048606 )
2019
39
Biomaterials for Cleft Lip and Palate Regeneration. ( 31052503 )
2019
40
Palatal morphology in unilateral cleft lip and palate patients: association with infant cleft dimensions and timing of hard palate repair. ( 31056824 )
2019
41
Epidemiology and clinical profile of individuals with cleft lip and palate utilising specialised academic treatment centres in South Africa. ( 31071123 )
2019
42
Dental development in cleft lip and palate patients: A systematic review. ( 31075568 )
2019
43
Bilateral Cleft Lip and Palate Accompanied by 13q- Syndrome with Deficiencies of FVII and FX: A Case Report. ( 31094634 )
2019
44
The Slavcleft: A three-center study of the outcome of treatment of cleft lip and palate. Part 2: Dental arch relationships. ( 31097367 )
2019
45
Incidence and management of cleft lip and palate in Pakistan. ( 31105281 )
2019
46
Speech in 5-year-olds born with unilateral cleft lip and palate: a Prospective Swedish Intercenter Study. ( 31107134 )
2019
47
Correlation Between Speech Outcomes and the Amount of Maxillary Advancement After Orthognathic Surgery (Le Fort I Conventional Osteotomy and Distraction Osteogenesis) in Patients With Cleft Lip and Palate. ( 31107383 )
2019
48
Cleft lip/palate and hereditary diffuse gastric cancer: report of a family harboring a CDH1 c.687 + 1G > A germline mutation and review of the literature. ( 30306390 )
2019
49
Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind, randomised study. ( 30308523 )
2019
50
Efficacy of rhBMP-2 in Cleft Lip and Palate Defects: Systematic Review and Meta-analysis. ( 30367200 )
2019
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Variations for Cleft Lip/palate

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Expression for Cleft Lip/palate

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Search GEO for disease gene expression data for Cleft Lip/palate.
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Pathways for Cleft Lip/palate

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Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Organelle biogenesis and maintenance 67
Show member pathways
 12.53 TCTEX1D2 WDR19 WDR34 WDR35 WDR60
2
Mesodermal Commitment Pathway 1
Show member pathways
 12.22 BMP4 FGFR1 WNT3 YAP1
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.75 BMP4 IRF6 MSX1 TP63
4
Hippo signaling pathway 38
11.74 BMP4 CDH1 DLG1 WNT3 YAP1
5
Neural Crest Differentiation 1
11.57 BMP4 CDH1 FGFR1 MSX1
6
Adherens junction 38
11.4 CDH1 FGFR1 NECTIN1
7
Intraflagellar transport 67
10.63 TCTEX1D2 WDR19 WDR34 WDR35 WDR60
8
Hypothetical Craniofacial Development Pathway 1
10.03 ARHGAP29 IRF6 TP63
Sources

GO Terms for Cleft Lip/palate

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Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.73 WDR19 WDR34 WDR35 WDR60
2 ciliary basal body GO:0036064 9.54 INTU WDR34 WDR35
3 axoneme GO:0005930 9.5 TCTEX1D2 WDR34 WDR35
4 apical junction complex GO:0043296 9.4 CDH1 NECTIN1
5 intraciliary transport particle A GO:0030991 9.26 WDR19 WDR35
6 interphase microtubule organizing center GO:0031021 9.16 TCTEX1D2 WDR60
7 cytoplasmic dynein complex GO:0005868 9.13 TCTEX1D2 WDR34 WDR60
8 ciliary tip GO:0097542 8.92 WDR19 WDR34 WDR35 WDR60

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell projection organization GO:0030030 9.84 INTU WDR19 WDR35 WDR60
2 embryonic digit morphogenesis GO:0042733 9.73 BMP4 INTU MSX1
3 odontogenesis of dentin-containing tooth GO:0042475 9.72 BMP4 MSX1 TP63
4 embryonic skeletal system morphogenesis GO:0048704 9.69 BMP4 DLG1 WDR60
5 ureteric bud development GO:0001657 9.67 BMP4 DLG1 FGFR1
6 keratinocyte differentiation GO:0030216 9.67 INTU IRF6 TP63 YAP1
7 camera-type eye morphogenesis GO:0048593 9.64 BMP4 NECTIN1
8 middle ear morphogenesis GO:0042474 9.64 FGFR1 MSX1
9 anterior/posterior axis specification GO:0009948 9.63 BMP4 WNT3
10 embryonic forelimb morphogenesis GO:0035115 9.63 MSX1 TP63 WNT3
11 establishment of planar polarity GO:0001736 9.62 INTU TP63
12 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.62 BMP4 MSX1
13 cell morphogenesis GO:0000902 9.62 MSX1 WDR19 WNT3 YAP1
14 intraciliary retrograde transport GO:0035721 9.61 WDR19 WDR35
15 organ induction GO:0001759 9.61 BMP4 FGFR1
16 pituitary gland development GO:0021983 9.61 BMP4 CDH1 MSX1
17 smooth muscle tissue development GO:0048745 9.6 BMP4 DLG1
18 mammary gland epithelium development GO:0061180 9.58 MSX1 WNT3
19 paraxial mesoderm development GO:0048339 9.58 FGFR1 YAP1
20 anatomical structure formation involved in morphogenesis GO:0048646 9.58 BMP4 TP63 WNT3
21 bud elongation involved in lung branching GO:0060449 9.57 BMP4 YAP1
22 intraciliary transport involved in cilium assembly GO:0035735 9.56 WDR19 WDR34 WDR35 WDR60
23 BMP signaling pathway involved in heart development GO:0061312 9.52 BMP4 MSX1
24 cloacal septation GO:0060197 9.48 BMP4 TP63
25 embryonic hindlimb morphogenesis GO:0035116 9.46 BMP4 MSX1 TP63 WNT3
26 cilium assembly GO:0060271 9.43 INTU TCTEX1D2 WDR19 WDR34 WDR35 WDR60
27 embryonic limb morphogenesis GO:0030326 9.02 BMP4 FGFR1 MSX1 TP63 WDR19
28 negative regulation of transcription by RNA polymerase II GO:0000122 10.07 BMP4 DLG1 DLX4 FGFR1 MSX1 TP63
29 positive regulation of transcription, DNA-templated GO:0045893 10.03 BMP4 CDH1 IRF6 TP63 YAP1

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dynein heavy chain binding GO:0045504 8.62 WDR34 WDR60
Sources

Sources for Cleft Lip/palate

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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