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FLP
MCID: CLF004
MIFTS: 54

Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cleft Lip/palate

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MalaCards integrated aliases for Cleft Lip/palate:

Name: Cleft Lip/palate 58 29
Cleft Lip and Palate 58 42
Cleft Lip-Alveolus-Palate Syndrome 58
Alveolar Cleft Lip and Palate 58
Flp 58

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Developmental anomalies during embryogenesis


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Summaries for Cleft Lip/palate

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MedlinePlus : 42 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and popliteal pterygium syndrome. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are G-protein signaling RAC1 in cellular process and Hippo signaling pathway. The drugs Fentanyl and Remifentanil have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and tongue, and related phenotypes are abnormality of dental eruption and delayed speech and language development

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Related Diseases for Cleft Lip/palate

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Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 567)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 35.3 TP63 NECTIN1 EEC1
2 popliteal pterygium syndrome 33.6 NECTIN1 MSX1 IRF6 ARHGAP29
3 short-rib thoracic dysplasia 6 with or without polydactyly 32.8 WDR35 DYNC2H1 CEP120
4 short-rib thoracic dysplasia 3 with or without polydactyly 32.8 WDR35 INTU DYNC2H1 CEP120
5 bartsocas-papas syndrome 32.6 TP63 IRF6
6 short-rib thoracic dysplasia 1 with or without polydactyly 32.6 WDR35 DYNC2H1 CEP120
7 ectodermal dysplasia 32.0 TP63 NECTIN1 MSX1 EEC1
8 isolated cleft lip 31.6 TP63 NECTIN1 MSX1 IRF6
9 van der woude syndrome 1 31.6 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
10 cleft lip and alveolus 31.1 TP63 NECTIN1 MSX1 IRF6
11 tooth size 30.8 MSX1 BMP4
12 anodontia 30.8 TP63 MSX1
13 chromosome 2q35 duplication syndrome 30.6 TP63 NECTIN1 MSX1 IRF6 FGFR1 BMP4
14 hard palate cancer 30.3 MSX1 IRF6 BMP4
15 ankyloglossia with or without tooth anomalies 30.3 MSX1 IRF6
16 coloboma of macula 30.2 YAP1 MSX1 FGFR1 BMP4
17 hemifacial microsomia 30.1 MSX1 FGFR1 BMP4
18 cleft palate, isolated 29.9 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
19 cleft lip with or without cleft palate 29.8 TGFA NECTIN1 MSX1 IRF6 CDH1 BMP4
20 cleft lip 29.6 YAP1 TP63 TGFA NECTIN1 MSX1 IRF6
21 tooth agenesis 29.6 WDR35 TP63 TGFA NECTIN1 MSX1 IRF6
22 orofacial cleft 28.9 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
23 cleft lip/palate-ectodermal dysplasia syndrome 13.1
24 ankyloblepharon-ectodermal defects-cleft lip/palate 13.1
25 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 13.0
26 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 13.0
27 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 13.0
28 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.7
29 cleft lip/palate with abnormal thumbs and microcephaly 12.6
30 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.6
31 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.6
32 radius, aplasia of, with cleft lip/palate 12.5
33 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.5
34 cleft lip palate dysmorphism kumar type 12.5
35 cleft lip palate oligodontia syndactyly pili torti 12.5
36 cleft lip palate pituitary deficiency 12.5
37 cleft lip palate-tetraphocomelia 12.5
38 craniosynostosis cleft lip palate arthrogryposis 12.5
39 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.5
40 cleft lip/palate-deafness-sacral lipoma syndrome 12.5
41 cleft lip and palate malrotation cardiopathy 12.5
42 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.5
43 rapp-hodgkin syndrome 12.4
44 hartsfield syndrome 12.4
45 cleft palate, cardiac defects, and mental retardation 12.3
46 vici syndrome 12.3
47 orofaciodigital syndrome vi 12.2
48 richieri-costa/guion-almeida syndrome 12.2
49 acrofrontofacionasal dysostosis 12.2
50 pilotto syndrome 12.1

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate
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Symptoms & Phenotypes for Cleft Lip/palate

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Human phenotypes related to Cleft Lip/palate:

58 31 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of dental eruption 58 31 hallmark (90%) Very frequent (99-80%) HP:0006292
2 delayed speech and language development 58 31 frequent (33%) Frequent (79-30%) HP:0000750
3 recurrent otitis media 58 31 frequent (33%) Frequent (79-30%) HP:0000403
4 poor suck 58 31 frequent (33%) Frequent (79-30%) HP:0002033
5 velopharyngeal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000220
6 speech articulation difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0009088
7 unilateral cleft palate 58 31 frequent (33%) Frequent (79-30%) HP:0100334
8 oral-pharyngeal dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0200136
9 dental malocclusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0000689
10 conductive hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000405
11 nasal speech 58 31 occasional (7.5%) Occasional (29-5%) HP:0001611
12 malnutrition 58 31 occasional (7.5%) Occasional (29-5%) HP:0004395
13 peg-shaped maxillary lateral incisors 58 31 occasional (7.5%) Occasional (29-5%) HP:0006342
14 palate fistula 58 31 occasional (7.5%) Occasional (29-5%) HP:0010294
15 abnormal number of permanent teeth 58 31 occasional (7.5%) Occasional (29-5%) HP:0011044
16 bilateral cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0100337
17 agenesis of lateral incisor 58 31 occasional (7.5%) Occasional (29-5%) HP:0200153
18 hypoplasia of the maxilla 58 31 very rare (1%) Very rare (<4-1%) HP:0000327
19 feeding difficulties in infancy 58 Frequent (79-30%)
20 cleft palate 58 Frequent (79-30%)
21 oral cleft 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Cleft Lip/palate:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.35 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
2 embryo MP:0005380 10.31 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
3 cardiovascular system MP:0005385 10.29 BMP4 CDH1 CEP120 DYNC2H1 FGFR1 INTU
4 digestive/alimentary MP:0005381 10.29 ARHGAP29 BMP4 CDH1 DLG1 DYNC2H1 FGFR1
5 cellular MP:0005384 10.28 BMP4 CDH1 CEP120 DLG1 DYNC2H1 FGFR1
6 homeostasis/metabolism MP:0005376 10.23 BMP4 CDH1 DLG1 FGFR1 INTU MSX1
7 craniofacial MP:0005382 10.22 ARHGAP29 BMP4 DLG1 DYNC2H1 FGFR1 IRF6
8 mortality/aging MP:0010768 10.21 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
9 integument MP:0010771 10.09 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
10 limbs/digits/tail MP:0005371 10.06 BMP4 DLG1 DYNC2H1 FGFR1 INTU IRF6
11 muscle MP:0005369 9.92 BMP4 DLG1 FGFR1 MSX1 TGFA TP63
12 renal/urinary system MP:0005367 9.8 BMP4 DLG1 DYNC2H1 FGFR1 INTU TP63
13 respiratory system MP:0005388 9.7 BMP4 DLG1 DYNC2H1 MSX1 TP63 WDR35
14 skeleton MP:0005390 9.7 BMP4 DLG1 DYNC2H1 FGFR1 INTU IRF6
15 vision/eye MP:0005391 9.28 BMP4 DLG1 DYNC2H1 FGFR1 INTU MSX1
Sources

Drugs & Therapeutics for Cleft Lip/palate

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Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Remifentanil Approved Phase 4 132875-61-7 60815
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
5
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
6
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
7
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
8 Narcotics Phase 4
9 Adjuvants, Anesthesia Phase 4
10 Anesthetics Phase 4
11 Anesthetics, General Phase 4
12 Analgesics, Opioid Phase 4
13 Anesthetics, Intravenous Phase 4
14 Central Nervous System Depressants Phase 4
15 Analgesics Phase 4
16 Neurotransmitter Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic alpha-2 Receptor Agonists Phase 4
19 Platelet Aggregation Inhibitors Phase 4
20 Analgesics, Non-Narcotic Phase 4
21 Anesthetics, Dissociative Phase 4
22 Hypnotics and Sedatives Phase 4
23 Anesthetics, Inhalation Phase 4
24 Adrenergic Agents Phase 4
25 Excitatory Amino Acid Antagonists Phase 4
26 Excitatory Amino Acids Phase 4
27
leucovorin Approved Phase 3 58-05-9 6006 143
28
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29 Micronutrients Phase 3
30 Hematinics Phase 3
31 Trace Elements Phase 3
32 Vitamins Phase 3
33 Nutrients Phase 3
34 Vitamin B Complex Phase 3
35 Vitamin B9 Phase 3
36 Folate Phase 3
37
Acetaminophen Approved Phase 2 103-90-2 1983
38
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
39
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
40 Anesthetics, Local Phase 2
41 Antipyretics Phase 2
42 Acetylcholine Release Inhibitors Phase 1, Phase 2
43 Neuromuscular Agents Phase 1, Phase 2
44 Botulinum Toxins Phase 1, Phase 2
45 Cholinergic Agents Phase 1, Phase 2
46 abobotulinumtoxinA Phase 1, Phase 2
47 Botulinum Toxins, Type A Phase 1, Phase 2
48
Morphine Approved, Investigational 57-27-2 5288826
49
Ropivacaine Approved 84057-95-4 71273 175805
50
Ferrous fumarate Approved 141-01-5

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Does Sevoflurane Induce Genomic Instability in Patients Undergoing General Anaesthesia? Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
2 Opioid Free Anaesthesia vs Opioid Based Anesthesia in Cleft Lip, Palate ,Alveolus Surgery. Not yet recruiting NCT04081909 Phase 4 Fentanyl，Remifentanil;Ketamine,Dexmedetomidine
3 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Clinical Evaluation of Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
6 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Recruiting NCT03766217 Phase 3
7 Velopharyngeal Function for Speech After Palatal Surgery Completed NCT00004639 Phase 2
8 Distraction Versus Orthognathic Surgery - Which One is Better for Cleft Palate Patients Completed NCT00930124 Phase 2
9 Evaluation of Postoperative Analgesic Effects of Bilateral Suprazygomatic Maxillary Nerve Block Using Bupivacaine and Dexmedetomidine in Children Undergoing Cleft Palate Repair Under General Anesthesia:Randomized Controlled Trial Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
10 Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
11 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489
12 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
13 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate: A Cross Sectional Study Unknown status NCT03219021
14 Osteogenesis and Dental Eruption Through Electrical Stimuli Following Periosteoplasty for Alveolar Clefts in Patients With Cleft Lip and Palate Deformities. A Preliminary Report. Unknown status NCT00975208
15 Distribution Of ABO Blood Groups In Relation To Cleft Lip And/or Palate . Unknown status NCT03217890
16 Stability of One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy: A Prospective Study Unknown status NCT01871623
17 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014
18 Follow Ups of Parents With Infants With Cleft Lip and Palate Unknown status NCT02415361
19 Improving Outcomes in Cleft Palate Surgery Through an Audit and Feedback Intervention Directed at Surgeons Unknown status NCT02583100
20 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
21 The Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Between Patients With and Without Pre-Alveolar Bone Graft Orthodontic Treatment Unknown status NCT02454998
22 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
23 Unilateral Cleft Repair in One Surgery With Pure Primary Healing Completed NCT04108416
24 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Completed NCT02881606
25 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Pain-related Temporomandibular Disorders Completed NCT03308266
26 Ultrasound Diagnosis of Cleft Lip and Palate - FENCHU Completed NCT03582111
27 Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients Completed NCT03686761
28 Emergence Delirium and Recovery Profile in Patients Undergoing Cleft Lip and Palate Repair: Comparison of Combination of Morphine and Fentanyl With Fentanyl Alone Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
29 Tympanometric Analysis in Post Surgical Individuals With Cleft Palate Completed NCT01820689
30 Efficacia Del Trattamento Chirurgico Maxillo-facciale Sul Volto Dei Bambini Con Labiopalatoschisi: Valutazioni Estetiche ed Ortodontiche Completed NCT03395015
31 Articulatory and Phonological Competence at 3 and 5 Years of Age in Children With Unilateral Cleft Lip and Palate Who Have Undergone Different Methods of Primary Palatal Surgery Completed NCT00829101
32 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients. A Prospective Randomized Trial Completed NCT02329509
33 Effect of A Novel (Modified Grayson) Technique for Nasoalveolar Molding and Taping on Parents' Satisfaction and Short Term Treatment Outcomes in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Controlled Trial Completed NCT02845193
34 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
35 Clinical, Volumetric and Densitometric Evaluation of Tissue Engineered (TE) Constructs for Secondary Alveolar Cleft Reconstruction (Short Term Randomized Controlled Clinical Trial) Completed NCT03563495
36 Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate Completed NCT03549039
37 Functional Outcomes of Cleft Lip and Lip Revision Surgery Completed NCT00070811
38 Comparison Between Alveolar Bone Graft With Only Cancellous Bone, and Alveolar Bone Graft With Cancellous Bone Combined With Nasal Cavity Floor's Reconstruction Using a Cortical Block Completed NCT03883373
39 OSAS in Children With Cleft Lip/Palate Completed NCT00156442
40 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
41 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
42 How Cerebral Oxygenation Correlates, Measured at Various Cranial Points, Frontally and Occipital in Children Under 1 Years Old, During General Anesthesia and Surgery Completed NCT03136952
43 Transversus Abdominis Plane Block Supplementation During Iliac Crest Bone Graft Harvest - Its Influence on Postoperative Parameters Completed NCT02997124
44 Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion: A Case Series Completed NCT03976609
45 A Comparison of the Skeletal and Dento-alveolar Changes After Treatment of Class III Malocclusion With a Modified Tandem Appliance Versus the Face Mask Completed NCT02144324
46 Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate Context Recruiting NCT04049058
47 Three-dimensional Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty: Classic and Geometric Morphometric Evaluation Recruiting NCT03839290
48 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC Recruiting NCT03065686
49 Ex Vivo and in Vitro Assessment of the Pharmacological Properties of Molecule Prima in the Restoration of Physiological Differentiation of Gene p63 Dependant Epithelium Recruiting NCT02896387
50 Three Dimensional Analysis of Maxillofacial Growth in Patients With Cleft Lip and Palate Recruiting NCT03514563

Search NIH Clinical Center for Cleft Lip/palate

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Genetic Tests for Cleft Lip/palate

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Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29
Sources

Anatomical Context for Cleft Lip/palate

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MalaCards organs/tissues related to Cleft Lip/palate:

40
Bone, Heart, Tongue, Skin, Lung, Eye, Pituitary
Sources

Publications for Cleft Lip/palate

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Articles related to Cleft Lip/palate:

(show top 50) (show all 7663)
# Title Authors PMID Year
1
Current concepts on cleft lip and palate etiology. 61 42
31538461 2019
2
Jaw and Dental Abnormalities. 42
31735222 2020
3
Case report of 49,XXXXY syndrome with cleft palate, diabetes, hypothyroidism, and cataracts. 42
31574874 2019
4
Scandcleft Project Trial 3: Comparison of Speech Outcomes in Relation to Sequence in 2-Stage Palatal Repair Procedures in 5-Year-Olds With Unilateral Cleft Lip and Palate. 61
31928085 2020
5
Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model. 61
31370691 2020
6
The 22q11.2 Microdeletion in Pediatric Patients with Cleft Lip, Palate, or Both and Congenital Heart Disease: A Systematic Review. 61
31976137 2020
7
Specialist hospital treatment and care as reported by children with intellectual disabilities and a cleft lip and/or palate, their parents and healthcare professionals. 61
31578815 2020
8
Comparison of Positive Screening for Obstructive Sleep Apnea in Patients With and Without Cleft Lip and Palate. 61
31529989 2020
9
Do Infant Cleft Dimensions Have an Influence on Occlusal Relations? A Subgroup Analysis Within an RCT of Primary Surgery in Patients With Unilateral Cleft Lip and Palate. 61
31619065 2020
10
YouTube as a Patient-Information Source for Cleft Lip and Palate. 61
31362515 2020
11
Evaluation of Congenital Maxillary Growth Using Computed Tomography in Patients With Bilateral Cleft Lip and Palate. 61
31522540 2020
12
Schneiderian Membrane Thickness Is Increased in Patients With Cleft Lip and Palate. 61
31648537 2020
13
Patients With Cleft Lip and Palate Associated With Intraoral Fibrous Bands: A Report of 3 Cases and Review of Literature. 61
31378081 2020
14
A Cone-Beam Computed Tomographic Study of Alveolar Bone Morphology in Patients With Unilateral Cleft Lip and Palate. 61
31529996 2020
15
Comment on: "A Bibliometric Analysis of Cleft Lip and Palate-Related Publication Trends From 2000 to 2017" by Zhang et al. (2019). 61
31409119 2020
16
Adherence to Orthodontic Treatment in Youth With Cleft Lip and/or Palate. 61
31394915 2020
17
Three-dimensional assessment of the pharyngeal airway in Japanese preschoolers with orofacial clefts. 61
30977521 2020
18
Decision-Making in Cleft-Related Surgery: A Qualitative Analysis of Patients and Caregivers. 61
31382774 2020
19
Trisomy 18 in a First-Trimester Fetus with Thoraco-Abdominal Ectopia Cordis. 61
31215820 2020
20
Deglutition in Patients With Hypernasality Associated With Unilateral Cleft Lip and Palate Evaluated With High-Resolution Manometry. 61
31672024 2020
21
[Identification of a Tp63 gene variant in an abortus with Ectrodactyly, Ectodermal dysplasia, Cleft lip/palate syndrome by whole-exome sequencing]. 61
32034739 2020
22
PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate. 61
31825181 2020
23
Maxillary shape at the end of puberty in operated unilateral cleft lip and palate: A geometric morphometric assessment using computer tomography. 61
31255828 2020
24
The Effect of Multiple Surgeries on Psychosocial Outcomes in Pediatric Patients: A Scoping Review. 61
32040002 2020
25
[Key signaling pathways associated with risks forcleft lip and palate]. 61
32034754 2020
26
The Economic Value of the Delivery of Primary Cleft Surgery in Timor Leste 2000-2017. 61
32030441 2020
27
Bone Regeneration in a Canine Model of Artificial Jaw Cleft Using Bone Marrow-Derived Mesenchymal Stem Cells and Carbonate Hydroxyapatite Carrier. 61
31422673 2020
28
Incidence of residual neuromuscular blockade in children below 3 years after a single bolus of cisatracurium 0.1 mg/kg: A quality assurance study. 61
31652351 2020
29
Leveraging Family History in Case-Control Analyses of Rare Variation. 61
31843756 2020
30
Eye-Tracking Technology in Plastic and Reconstructive Surgery: A Systematic Review. 61
32010929 2020
31
The Reducing Opioid Use in Children with Clefts Protocol: A Multidisciplinary Quality Improvement Effort to Reduce Perioperative Opioid Use in Patients Undergoing Cleft Surgery. 61
31985649 2020
32
Internationally Adopted Children With Unilateral Cleft Lip and Palate-Consonant Proficiency and Perceived Velopharyngeal Competence at the Age of 5. 61
31950849 2020
33
A Psychologic Assessment of the Parents of Patients With Cleft Lip and Palate. 61
31369507 2020
34
Opinions of Speech-Language Pathologists Regarding Speech Management for Children With Cleft Lip and Palate. 61
31220929 2020
35
Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure. 61
32005677 2020
36
Relationship of Velopharyngeal Insufficiency With Face Mask Therapy in Patients With Cleft Lip and Palate. 61
31366211 2020
37
Exploring GRHL3 polymorphisms and SNP-SNP interactions in the risk of non-syndromic oral clefts in the Brazilian population. 61
31564061 2020
38
Target Capture/Next-Generation Sequencing for Nonsyndromic Cleft Lip and Palate in the Japanese Population. 61
31337262 2020
39
Pattern of malocclusion and caries experience in unrepaired cleft lip and palate patients in Enugu. 61
31929208 2020
40
Perioperative Management in Patients With Cleft Lip and Palate. 61
31633673 2020
41
Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level. 61
31900751 2020
42
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: dental anomalies in 8-year olds. 61
31579919 2020
43
Dental Anomalies in Permanent Teeth Associated With Nonsyndromic Cleft Lip and Palate in a Group of Colombian Children. 61
31284730 2020
44
Association between MSX1 rs12532 polymorphism with nonsyndromic unilateral complete cleft lip and palate and tooth agenesis. 61
31568994 2020
45
NUP188 Biallelic Loss of Function May Underlie a New Syndrome: Nucleoporin 188 Insufficiency Syndrome? 61
32021605 2020
46
Congenital Four Eyelid Ectropion Associated With Clefting Anomaly. 61
32011540 2020
47
Scandcleft randomized trials of primary surgery for unilateral cleft lip and palate: maxillary growth at eight years of age. 61
31586198 2020
48
Longitudinal study of the development of obstruent correctness from ages 3 to 5 years in 108 Danish children with unilateral cleft lip and palate: a sub-study within a multicentre randomized controlled trial. 61
31710176 2020
49
Evaluation Of Nasolabial Aesthetics By Different Groups In Operated Unilateral Cleft Lip And Palate. 61
32007634 2020
50
Cone-Beam Computed Tomography Incidental Findings in Individuals With Cleft Lip and Palate. 61
31964169 2020
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Variations for Cleft Lip/palate

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Expression for Cleft Lip/palate

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Search GEO for disease gene expression data for Cleft Lip/palate.
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Pathways for Cleft Lip/palate

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Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.06 TGFA FGFR1 DLG1 CDH1 BMP4
2
Hippo signaling pathway 36
11.75 YAP1 DLG1 CDH1 BMP4
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.58 TP63 MSX1 IRF6 BMP4
4
Adherens junction 36
11.35 NECTIN1 FGFR1 CDH1
5
Neural Crest Differentiation 1
11.27 MSX1 FGFR1 CDH1 BMP4
6
Hypothetical Craniofacial Development Pathway 1
9.7 TP63 IRF6 ARHGAP29
Sources

GO Terms for Cleft Lip/palate

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Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 8.62 NECTIN1 CDH1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.03 TP63 MSX1 FGFR1 DLX4 DLG1 BMP4
2 positive regulation of transcription, DNA-templated GO:0045893 10.02 YAP1 TP63 IRF6 CDH1 BMP4
3 positive regulation of cell proliferation GO:0008284 9.99 YAP1 TGFA FGFR1 DLG1 BMP4
4 regulation of gene expression GO:0010468 9.88 YAP1 FGFR1 CDH1 BMP4
5 cell morphogenesis GO:0000902 9.77 YAP1 MSX1 CDH1
6 forebrain development GO:0030900 9.69 MSX1 DYNC2H1 BMP4
7 odontogenesis of dentin-containing tooth GO:0042475 9.67 TP63 MSX1 BMP4
8 embryonic morphogenesis GO:0048598 9.63 MSX1 BMP4
9 middle ear morphogenesis GO:0042474 9.62 MSX1 FGFR1
10 anatomical structure formation involved in morphogenesis GO:0048646 9.61 TP63 BMP4
11 establishment of planar polarity GO:0001736 9.61 TP63 INTU
12 embryonic digit morphogenesis GO:0042733 9.61 MSX1 INTU BMP4
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.58 MSX1 BMP4
14 organ induction GO:0001759 9.57 FGFR1 BMP4
15 smooth muscle tissue development GO:0048745 9.55 DLG1 BMP4
16 intraciliary retrograde transport GO:0035721 9.54 WDR35 DYNC2H1
17 ureteric bud development GO:0001657 9.54 FGFR1 DLG1 BMP4
18 paraxial mesoderm development GO:0048339 9.52 YAP1 FGFR1
19 bud elongation involved in lung branching GO:0060449 9.48 YAP1 BMP4
20 astral microtubule organization GO:0030953 9.46 DLG1 CEP120
21 pituitary gland development GO:0021983 9.43 MSX1 CDH1 BMP4
22 BMP signaling pathway involved in heart development GO:0061312 9.4 MSX1 BMP4
23 embryonic hindlimb morphogenesis GO:0035116 9.33 TP63 MSX1 BMP4
24 cloacal septation GO:0060197 9.32 TP63 BMP4
25 keratinocyte differentiation GO:0030216 9.26 YAP1 TP63 IRF6 INTU
26 embryonic limb morphogenesis GO:0030326 9.02 TP63 MSX1 FGFR1 DYNC2H1 BMP4
Sources

Sources for Cleft Lip/palate

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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