FLP
MCID: CLF004
MIFTS: 55

Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 43 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 7 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Coagulants and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and skin, and related phenotypes are embryo and cellular

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 34.6 EEC1 TP63
2 short-rib thoracic dysplasia 7 with or without polydactyly 32.5 INTU WDR35
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.3 NEK1 WDR19 WDR35 WDR60
4 short-rib thoracic dysplasia 12 32.1 NEK1 WDR19
5 bartsocas-papas syndrome 32.0 IRF6 TP63
6 short-rib thoracic dysplasia 1 with or without polydactyly 31.8 WDR19 WDR35 WDR60
7 cleft lip 31.0 ARHGAP29 BMP4 CDH1 DLX4 FGFR1 IRF6
8 cleft lip and alveolus 30.9 IRF6 MSX1 NECTIN1 TP63
9 isolated cleft lip 30.7 IRF6 MSX1 NECTIN1 TP63
10 tooth size 30.5 BMP4 MSX1
11 tooth agenesis 29.9 BMP4 CDH1 FGFR1 IRF6 MSX1
12 cleft palate, isolated 29.9 ARHGAP29 BMP4 FGFR1 IRF6 MSX1 NECTIN1
13 ankyloblepharon-ectodermal defects-cleft lip/palate 12.9
14 cleft lip/palate-ectodermal dysplasia syndrome 12.9
15 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 12.8
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 12.8
17 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 12.7
18 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.6
19 tibial hemimelia cleft lip palate 12.5
20 cleft lip/palate with abnormal thumbs and microcephaly 12.5
21 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.4
22 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.4
23 radius, aplasia of, with cleft lip/palate 12.4
24 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.4
25 cleft lip palate dysmorphism kumar type 12.4
26 cleft lip palate oligodontia syndactyly pili torti 12.4
27 cleft lip palate pituitary deficiency 12.4
28 cleft lip palate-tetraphocomelia 12.4
29 craniosynostosis cleft lip palate arthrogryposis 12.4
30 holoprosencephaly ectrodactyly cleft lip palate 12.4
31 lagophthalmia cleft lip palate 12.4
32 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.4
33 cleft lip/palate-deafness-sacral lipoma syndrome 12.4
34 cleft lip and palate malrotation cardiopathy 12.3
35 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.3
36 popliteal pterygium syndrome 12.2
37 rapp-hodgkin syndrome 12.2
38 hartsfield syndrome 12.2
39 blepharocheilodontic syndrome 1 12.1
40 vici syndrome 12.1
41 richieri-costa/guion-almeida syndrome 12.1
42 acrofrontofacionasal dysostosis 12.0
43 cleft palate, cardiac defects, and mental retardation 12.0
44 zlotogora syndrome 12.0
45 uveal coloboma-cleft lip and palate-intellectual disability 11.8
46 pilotto syndrome 11.8
47 orofaciodigital syndrome vi 11.8
48 martinez monasterio pinheiro syndrome 11.7
49 samson viljoen syndrome 11.6
50 kapur-toriello syndrome 11.6

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

MGI Mouse Phenotypes related to Cleft Lip/palate:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.37 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
2 cellular MP:0005384 10.35 BMP4 CDH1 DLG1 FGFR1 INTU IRF6
3 growth/size/body region MP:0005378 10.35 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
4 craniofacial MP:0005382 10.3 ARHGAP29 BMP4 DLG1 FGFR1 IRF6 MEIS2
5 mortality/aging MP:0010768 10.3 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 INTU
6 digestive/alimentary MP:0005381 10.29 ARHGAP29 BMP4 CDH1 DLG1 FGFR1 IRF6
7 cardiovascular system MP:0005385 10.2 BMP4 CDH1 FGFR1 INTU MEIS2 MSX1
8 limbs/digits/tail MP:0005371 10.1 BMP4 DLG1 FGFR1 INTU IRF6 MSX1
9 integument MP:0010771 10.09 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
10 nervous system MP:0003631 9.96 BMP4 DLG1 FGFR1 INTU MEIS2 MSX1
11 hearing/vestibular/ear MP:0005377 9.93 BMP4 FGFR1 IRF6 MEIS2 MSX1 WDR19
12 muscle MP:0005369 9.92 BMP4 DLG1 FGFR1 MSX1 TP63 WDR19
13 skeleton MP:0005390 9.73 BMP4 DLG1 FGFR1 INTU IRF6 MEIS2
14 renal/urinary system MP:0005367 9.7 BMP4 DLG1 FGFR1 INTU NEK1 TP63
15 vision/eye MP:0005391 9.28 BMP4 DLG1 FGFR1 INTU MEIS2 MSX1

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Coagulants Phase 4
2 Fibrin Tissue Adhesive Phase 4
3 Hemostatics Phase 4
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
6 Vitamins Phase 3
7 Vitamin B9 Phase 3
8 Vitamin B Complex Phase 3
9 Micronutrients Phase 3
10 Folate Phase 3
11 Hematinics Phase 3
12 Trace Elements Phase 3
13
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
14
Acetaminophen Approved Phase 2 103-90-2 1983
15
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
16
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
17 Anesthetics Phase 2,Not Applicable
18 Antipyretics Phase 2
19 Adrenergic Agonists Phase 2
20 Anesthetics, Local Phase 2
21 Neurotransmitter Agents Phase 2,Phase 1
22 Central Nervous System Depressants Phase 2,Not Applicable
23 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable
24 Adrenergic alpha-Agonists Phase 2
25 Analgesics Phase 2,Not Applicable
26 Adrenergic alpha-2 Receptor Agonists Phase 2
27 Adrenergic Agents Phase 2
28 Hypnotics and Sedatives Phase 2
29 Analgesics, Non-Narcotic Phase 2
30 Acetylcholine Release Inhibitors Phase 1, Phase 2
31 Botulinum Toxins, Type A Phase 1, Phase 2
32 Cholinergic Agents Phase 1, Phase 2
33 abobotulinumtoxinA Phase 1, Phase 2
34 Neuromuscular Agents Phase 1, Phase 2
35 onabotulinumtoxinA Phase 1, Phase 2
36 Botulinum Toxins Phase 1, Phase 2
37
Fentanyl Approved, Illicit, Investigational, Vet_approved Not Applicable 437-38-7 3345
38
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
39 Adjuvants, Anesthesia Not Applicable
40 Analgesics, Opioid Not Applicable
41 Narcotics Not Applicable
42 Anesthetics, Intravenous Not Applicable
43 Anesthetics, General Not Applicable

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Recruiting NCT02953145 Phase 4 Tisseel
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
6 Cleft Orthognathic Surgery Versus Distraction Osteogenesis - Which is Better? Completed NCT00930124 Phase 2
7 Cleft Palate Surgery and Speech Development Completed NCT00004639 Phase 2
8 Suprazygomatic Block in Cleft Palate Surgery in Children Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 Improvement of the Appearance of Cleft Lip Scars Using Botox Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
10 One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy Unknown status NCT01871623 Not Applicable
11 Alveolar Bone Grafting Outcome Between Patient With and Without Orthodontic Treatment Unknown status NCT02454998 Not Applicable
12 Osteogenesis and Dental Eruption Through Electrical Stimuli Unknown status NCT00975208
13 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687 Not Applicable
14 IAN Injury After BSSO in Oral Clefts Unknown status NCT01875965
15 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014 Not Applicable
16 Ultrasound Diagnosis of Cleft Lip and Palate Completed NCT03582111
17 A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate Completed NCT00156442
18 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164 Not Applicable
19 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Temporomandibular Disorders Completed NCT03308266
20 Articulation and Phonology in Children With Unilateral Cleft Lip and Palate Completed NCT00829101
21 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients Completed NCT02329509 Not Applicable
22 Effect Of Combination of Morphine+Fentanyl on Emergence Delirium in Patients of Cleft Lip and Palate Repair Completed NCT03010540 Not Applicable MORPHINE PLUS FENTANYL;Fentanyl
23 Assessing the Results of Lip Surgery in Patients With Cleft Lip and Palate Completed NCT00070811
24 Efficacy of Maxillo-facial Treatment on Cleft Lip and Palate Patients Faces: Aesthetic Considerations Completed NCT03395015
25 Periodontal Changes Following Mid Maxillary Distraction Completed NCT03686761 Not Applicable
26 Primary Palatoplasty in Pediatric Patients - A Retrospective Review of Surgical Outcomes Completed NCT01380171
27 Tissue Engineered Constructs for Alveolar Cleft Repair Completed NCT03563495 Not Applicable
28 Relational Development in Children With Cleft Lips and Palates: Influence of the Waiting Period Prior to the First Surgical Intervention and the Parents' Psychological Perception of the Abnormality Completed NCT00993993
29 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149 Not Applicable
30 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
31 Tympanometric Analysis in Cleft Palate Completed NCT01820689 Not Applicable
32 Study of the Experiences and Needs of Parents Continuing a Pregnancy Following a Prenatal Diagnosis of Holopresencephaly Completed NCT00005016
33 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
34 Child and Infant Learning Project Completed NCT00077831
35 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Recruiting NCT02789787
36 Three Dimensional Facial Growth Analysis Recruiting NCT03514563
37 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606 Not Applicable
38 Otologic and Rhinologic Outcomes in Children With Clef Palate Recruiting NCT03708406
39 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing Recruiting NCT03065686 Not Applicable
40 Prospective Data-collection System for the Comprehensive Appraisal of Cleft Care Recruiting NCT02702869
41 Ability of a Molecule (Prima) to Restore Physiological Differentiation in Epithelium Expressing Gene p63 Recruiting NCT02896387
42 Extended Criteria For Fetal Myelomeningocele Repair Recruiting NCT02664207 Not Applicable
43 Targeting Surgeons' Decision-Making for Cleft Lip Surgery Recruiting NCT03537976 Not Applicable
44 Nasoalveolar Molding for Egyptian Cleft Lip Palate Infants Active, not recruiting NCT03029195 Not Applicable
45 Efficiency of Novel Nasoalveolar Molding Techniques on Parents' Satisfaction and Short Term Treatment Outcomes in Unilateral Cleft Lip and Palate Infants: A Randomized Controlled Trial Active, not recruiting NCT02845193 Not Applicable
46 Follow Ups of Parents With Infants With Cleft Lip and Palate Active, not recruiting NCT02415361 Not Applicable
47 Online Psychosocial Support for Young People With a Visible Difference: A Randomised Control Study Active, not recruiting NCT03165331 Not Applicable
48 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Not yet recruiting NCT03011489 Not Applicable
49 Oral Hygiene and Connected Toothbrush Before Alveolar Bone Graft for Cleft Lip and Palate Not yet recruiting NCT03750708 Not Applicable
50 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate Not yet recruiting NCT03219021

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

41
Bone, Heart, Skin, Kidney, Lung, Breast, Thymus

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 1774)
# Title Authors Year
1
Child development skills and language in toddlers with cleft lip and palate. ( 30554694 )
2019
2
Bilateral suprazygomatic maxillary nerve blocks vs. infraorbital and palatine nerve blocks in cleft lip and palate repair: A double-blind, randomised study. ( 30308523 )
2019
3
The Difference in Cervical Vertebral Skeletal Maturation between Cleft Lip/Palate and Non-Cleft Lip/Palate Orthodontic Patients. ( 29619373 )
2018
4
Rethinking isolated cleft lip and palate as a syndrome. ( 29500156 )
2018
5
Effects of Nasoalveolar Molding Therapy on Alveolar and Palatal Cleft Deformities in Unilateral and Bilateral Cleft Lip and Palate. ( 29381641 )
2018
6
Cleft Lip and Palate in CHARGE Syndrome: Phenotypic Features That Influence Management. ( 29437513 )
2018
7
The Impact of Maxillary Advancement on Consonant Proficiency in Patients With Cleft Lip and Palate, Lay Listeners' Opinion, and Patients' Satisfaction With Speech. ( 29949386 )
2018
8
A case of cleft lip and palate with severe maxillary retrognathism treated by distraction osteogenesis and custom made intraoral rapid maxillary expansion appliance: A 2-year follow-up of retention. ( 29937663 )
2018
9
Acoustic analysis of misarticulated trills in cleft lip and palate children. ( 29960457 )
2018
10
Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. ( 29388416 )
2018
11
Long-Term Skeletal Changes After Maxillary Distraction Osteogenesis in Growing Children With Cleft Lip/Palate. ( 29461366 )
2018
12
3D Assessment of Nasolabial Appearance in Patients With Complete Unilateral Cleft Lip and Palate. ( 29351025 )
2018
13
The use of throat packs in pediatric cleft lip/palate surgery: a retrospective study. ( 29473105 )
2018
14
A Case of Ankyloblepharon-ectodermal Defects-cleft Lip/palate-syndrome with Choanal Atresia and Skin Erosions: Phenotypic Variability of TP63-related Disorders. ( 29956718 )
2018
15
Bone-anchored maxillary protraction in a patient with complete cleft lip and palate: A case report. ( 29407507 )
2018
16
Tooth-borne distraction osteogenesis versus conventional Le Fort I in maxillary advancement of cleft lip and palate patients. ( 29388417 )
2018
17
BRCA1 and BRCA2 gene variants and nonsyndromic cleft lip/palate. ( 29921024 )
2018
18
Novel <i>TBX22</i> mutations in Chinese nonsyndromic cleft lip/palate families. ( 29932061 )
2018
19
Influence of involuntary facial expressions on reproducibility of 3D stereophotogrammetry in children with and without complete unilateral cleft lip and palate from 3 to 18A months of age. ( 29943366 )
2018
20
Comprehensive Genetic Screening Recommended for Nonsyndromic Cleft Lip/Palate: Even in the absence of any signs of a syndrome, patients with cleft lip/palate may still carry a mutation in a gene linked to a syndrome and should receive comprehensive genetic testing. ( 29878711 )
2018
21
PVR/CD155 Ala67Thr Mutation and Cleft Lip/Palate. ( 29381645 )
2018
22
Strong Association of C677T Polymorphism of Methylenetetrahydrofolate Reductase Gene With Nosyndromic Cleft Lip/Palate (nsCL/P). ( 29371764 )
2018
23
Single-Stage Primary Cleft Lip and Palate Repair: A Review of the Literature. ( 29944528 )
2018
24
A Comparative Evaluation of Efficacy and Efficiency of Grayson's Presurgical Nasoalveolar Molding Technique in Patients with Complete Unilateral Cleft Lip and Palate with Those Treated with Figueroa's Modified Technique. ( 29962760 )
2018
25
Assessment of facial asymmetry before and after the surgical repair of cleft lip in unilateral cleft lip and palate cases. ( 28967531 )
2018
26
3D-Printed Models of Cleft Lip and Palate for Surgical Training and Patient Education. ( 29437509 )
2018
27
A novel non-coding RNA within an intron of CDH2 and association of its SNP with non-syndromic cleft lip and palate. ( 29524576 )
2018
28
Evaluation of Airway Volume in Cleft Lip and Palate Following Nasoalveolar Molding. ( 29944553 )
2018
29
Minimally invasive versus standard approach in LeFort 1 osteotomy in patients with history of cleft lip and palate. ( 29408322 )
2018
30
Three-dimensional radiological evaluation of secondary alveolar bone grafting in cleft lip and palate patients: a systematic review. ( 29947253 )
2018
31
A Pediatrician's Guide to Communication Disorders Secondary to Cleft Lip/Palate. ( 29173718 )
2018
32
Quantifying Soft Tissue Shape and Symmetry: Patients with Cleft Lip/Palate and Facial Paralysis. ( 29707466 )
2018
33
The Effect of Nasoalveolar Molding on Nasal Airway Anatomy: A 9-Year Follow-up of Patients With Unilateral Cleft Lip and Palate. ( 29356619 )
2018
34
Impact of Temporomandibular Disorders and Sleep Bruxism on Oral Health-Related Quality of Life of Individuals With Complete Cleft Lip and Palate. ( 30074958 )
2018
35
Caregiver-Reported Outcomes and Barriers to Care among Patients with Cleft Lip and Palate. ( 30489528 )
2018
36
Associated parameters of canine impaction in patients with unilateral cleft lip and palate after secondary alveolar bone grafting: a retrospective study. ( 30500916 )
2018
37
A Novel Approach for the Reconstruction of Premaxilla by Archwise Distraction in Bilateral Cleft Lip and Palate. ( 30507876 )
2018
38
The role of external aetiological factors in dental anomalies in non-syndromic cleft lip and palate patients. ( 30511277 )
2018
39
Early Weight Gain in Infants With Cleft Lip and Palate Treated With and Without Nasoalveolar Molding: A Retrospective Study. ( 30514093 )
2018
40
Quality of life and mastication in denture wearers and cleft lip and palate adults. ( 30517426 )
2018
41
Importance of glottis landmarks for the assessment of cleft lip and palate speech intelligibility. ( 30522275 )
2018
42
The effect of facial expression on facial symmetry in surgically managed unilateral cleft lip and palate patients (UCLP). ( 30522896 )
2018
43
Clinical Outcomes Utilizing a "Modified Latham" Appliance for Presurgical Infant Orthopedics in Patients With Unilateral Complete Cleft Lip and Palate. ( 30526003 )
2018
44
A Programmable Expander for Patients With Cleft Lip and Palate. ( 30526006 )
2018
45
Comment on Malmborn, Becker, and Klintö: Problems With Reliability of Speech Variables for Use in Quality Registries for Cleft Lip and Palate-Experiences From the Swedish Cleft Lip and Palate Registry, CPCJ 2018. ( 30526009 )
2018
46
Secondary alveolar bone grafting in cleft lip and palate: A comparative analysis of donor site morbidity in different age groups. ( 30527380 )
2018
47
Combined Primary Cleft Lip and Palate Repair: Is It Safe? ( 30531281 )
2018
48
Outcome of Patients with Complete Unilateral Cleft Lip and Palate: 20-Years Follow-up of Treatment Protocol. ( 30531628 )
2018
49
OSC10: Observation of the Teeth Position in Cleft Lip and Palate Patients using Three-Dimensional Assessment. ( 30532403 )
2018
50
Prenatal diagnosis of cleft lip and cleft lip palate - a case series. ( 30534664 )
2018

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 9.26 CDH1 NECTIN1
2 pericentriolar material GO:0000242 9.16 NEK1 WDR60
3 intraciliary transport particle A GO:0030991 8.96 WDR19 WDR35
4 ciliary tip GO:0097542 8.8 WDR19 WDR35 WDR60

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.98 BMP4 DLG1 DLX4 FGFR1 MEIS2 MSX1
2 embryonic digit morphogenesis GO:0042733 9.74 BMP4 INTU MSX1
3 odontogenesis of dentin-containing tooth GO:0042475 9.73 BMP4 MSX1 TP63
4 cilium assembly GO:0060271 9.72 INTU NEK1 WDR19 WDR35 WDR60
5 embryonic skeletal system morphogenesis GO:0048704 9.71 BMP4 DLG1 WDR60
6 ureteric bud development GO:0001657 9.7 BMP4 DLG1 FGFR1
7 intraciliary transport involved in cilium assembly GO:0035735 9.69 WDR19 WDR35 WDR60
8 keratinocyte differentiation GO:0030216 9.67 INTU IRF6 TP63 YAP1
9 camera-type eye morphogenesis GO:0048593 9.65 BMP4 NECTIN1
10 embryonic forelimb morphogenesis GO:0035115 9.65 MSX1 TP63 WNT3
11 middle ear morphogenesis GO:0042474 9.64 FGFR1 MSX1
12 anterior/posterior axis specification GO:0009948 9.63 BMP4 WNT3
13 establishment of planar polarity GO:0001736 9.63 INTU TP63
14 pituitary gland development GO:0021983 9.63 BMP4 CDH1 MSX1
15 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.62 BMP4 MSX1
16 intraciliary retrograde transport GO:0035721 9.62 WDR19 WDR35
17 organ induction GO:0001759 9.61 BMP4 FGFR1
18 smooth muscle tissue development GO:0048745 9.61 BMP4 DLG1
19 mammary gland epithelium development GO:0061180 9.6 MSX1 WNT3
20 paraxial mesoderm development GO:0048339 9.59 FGFR1 YAP1
21 bud elongation involved in lung branching GO:0060449 9.58 BMP4 YAP1
22 anatomical structure formation involved in morphogenesis GO:0048646 9.58 BMP4 TP63 WNT3
23 cell morphogenesis GO:0000902 9.56 MSX1 WDR19 WNT3 YAP1
24 BMP signaling pathway involved in heart development GO:0061312 9.55 BMP4 MSX1
25 cell projection organization GO:0030030 9.55 INTU NEK1 WDR19 WDR35 WDR60
26 cloacal septation GO:0060197 9.49 BMP4 TP63
27 embryonic hindlimb morphogenesis GO:0035116 9.26 BMP4 MSX1 TP63 WNT3
28 embryonic limb morphogenesis GO:0030326 9.02 BMP4 FGFR1 MSX1 TP63 WDR19
29 multicellular organism development GO:0007275 10.13 BMP4 DLX4 INTU MEIS2 MSX1 TP63
30 positive regulation of transcription, DNA-templated GO:0045893 10.04 BMP4 CDH1 IRF6 TP63 YAP1

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.02 DLX4 IRF6 MEIS2 MSX1 TP63

Sources for Cleft Lip/palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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