FLP
MCID: CLF004
MIFTS: 55

Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 42 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and popliteal pterygium syndrome. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are G-protein signaling RAC1 in cellular process and Hippo signaling pathway. The drugs Fentanyl and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and tongue, and related phenotypes are abnormality of dental eruption and delayed speech and language development

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 567)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 35.3 TP63 NECTIN1 EEC1
2 popliteal pterygium syndrome 33.6 NECTIN1 MSX1 IRF6 ARHGAP29
3 short-rib thoracic dysplasia 6 with or without polydactyly 32.8 WDR35 DYNC2H1 CEP120
4 short-rib thoracic dysplasia 3 with or without polydactyly 32.7 WDR35 INTU DYNC2H1 CEP120
5 bartsocas-papas syndrome 32.6 TP63 IRF6
6 short-rib thoracic dysplasia 1 with or without polydactyly 32.6 WDR35 DYNC2H1 CEP120
7 ectodermal dysplasia 32.0 TP63 NECTIN1 MSX1 EEC1
8 isolated cleft lip 31.6 TP63 NECTIN1 MSX1 IRF6
9 van der woude syndrome 1 31.6 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
10 cleft lip and alveolus 31.1 TP63 NECTIN1 MSX1 IRF6
11 tooth size 30.8 MSX1 BMP4
12 anodontia 30.8 TP63 MSX1
13 chromosome 2q35 duplication syndrome 30.6 TP63 NECTIN1 MSX1 IRF6 FGFR1 BMP4
14 hard palate cancer 30.3 MSX1 IRF6 BMP4
15 ankyloglossia with or without tooth anomalies 30.3 MSX1 IRF6
16 coloboma of macula 30.1 YAP1 MSX1 FGFR1 BMP4
17 cleft palate, isolated 29.9 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
18 cleft lip with or without cleft palate 29.8 TGFA NECTIN1 MSX1 IRF6 CDH1 BMP4
19 tooth agenesis 29.6 WDR35 TP63 TGFA NECTIN1 MSX1 IRF6
20 cleft lip 29.6 YAP1 TP63 TGFA NECTIN1 MSX1 IRF6
21 orofacial cleft 28.9 TP63 TGFA NECTIN1 MSX1 IRF6 FGFR1
22 cleft lip/palate-ectodermal dysplasia syndrome 13.1
23 ankyloblepharon-ectodermal defects-cleft lip/palate 13.1
24 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 13.0
25 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 13.0
26 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 13.0
27 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.7
28 cleft lip/palate with abnormal thumbs and microcephaly 12.6
29 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.6
30 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.6
31 radius, aplasia of, with cleft lip/palate 12.5
32 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.5
33 cleft lip palate dysmorphism kumar type 12.5
34 cleft lip palate oligodontia syndactyly pili torti 12.5
35 cleft lip palate pituitary deficiency 12.5
36 cleft lip palate-tetraphocomelia 12.5
37 craniosynostosis cleft lip palate arthrogryposis 12.5
38 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.5
39 cleft lip/palate-deafness-sacral lipoma syndrome 12.5
40 cleft lip and palate malrotation cardiopathy 12.5
41 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.5
42 rapp-hodgkin syndrome 12.4
43 hartsfield syndrome 12.4
44 cleft palate, cardiac defects, and mental retardation 12.3
45 vici syndrome 12.3
46 orofaciodigital syndrome vi 12.2
47 richieri-costa/guion-almeida syndrome 12.2
48 acrofrontofacionasal dysostosis 12.2
49 pilotto syndrome 12.1
50 orofacial cleft 1 12.0

Graphical network of the top 20 diseases related to Cleft Lip/palate:



Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

Human phenotypes related to Cleft Lip/palate:

58 31 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of dental eruption 58 31 hallmark (90%) Very frequent (99-80%) HP:0006292
2 delayed speech and language development 58 31 frequent (33%) Frequent (79-30%) HP:0000750
3 recurrent otitis media 58 31 frequent (33%) Frequent (79-30%) HP:0000403
4 poor suck 58 31 frequent (33%) Frequent (79-30%) HP:0002033
5 velopharyngeal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000220
6 speech articulation difficulties 58 31 frequent (33%) Frequent (79-30%) HP:0009088
7 unilateral cleft palate 58 31 frequent (33%) Frequent (79-30%) HP:0100334
8 oral-pharyngeal dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0200136
9 dental malocclusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0000689
10 conductive hearing impairment 58 31 occasional (7.5%) Occasional (29-5%) HP:0000405
11 nasal speech 58 31 occasional (7.5%) Occasional (29-5%) HP:0001611
12 malnutrition 58 31 occasional (7.5%) Occasional (29-5%) HP:0004395
13 peg-shaped maxillary lateral incisors 58 31 occasional (7.5%) Occasional (29-5%) HP:0006342
14 palate fistula 58 31 occasional (7.5%) Occasional (29-5%) HP:0010294
15 abnormal number of permanent teeth 58 31 occasional (7.5%) Occasional (29-5%) HP:0011044
16 bilateral cleft palate 58 31 occasional (7.5%) Occasional (29-5%) HP:0100337
17 agenesis of lateral incisor 58 31 occasional (7.5%) Occasional (29-5%) HP:0200153
18 hypoplasia of the maxilla 58 31 very rare (1%) Very rare (<4-1%) HP:0000327
19 feeding difficulties in infancy 58 Frequent (79-30%)
20 cleft palate 58 Frequent (79-30%)
21 oral cleft 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Cleft Lip/palate:

45 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.35 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
2 embryo MP:0005380 10.31 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
3 cardiovascular system MP:0005385 10.29 BMP4 CDH1 CEP120 DYNC2H1 FGFR1 INTU
4 digestive/alimentary MP:0005381 10.29 ARHGAP29 BMP4 CDH1 DLG1 DYNC2H1 FGFR1
5 cellular MP:0005384 10.28 BMP4 CDH1 CEP120 DLG1 DYNC2H1 FGFR1
6 homeostasis/metabolism MP:0005376 10.23 BMP4 CDH1 DLG1 FGFR1 INTU MSX1
7 craniofacial MP:0005382 10.22 ARHGAP29 BMP4 DLG1 DYNC2H1 FGFR1 IRF6
8 mortality/aging MP:0010768 10.21 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
9 integument MP:0010771 10.09 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
10 limbs/digits/tail MP:0005371 10.06 BMP4 DLG1 DYNC2H1 FGFR1 INTU IRF6
11 muscle MP:0005369 9.92 BMP4 DLG1 FGFR1 MSX1 TGFA TP63
12 renal/urinary system MP:0005367 9.8 BMP4 DLG1 DYNC2H1 FGFR1 INTU TP63
13 respiratory system MP:0005388 9.7 BMP4 DLG1 DYNC2H1 MSX1 TP63 WDR35
14 skeleton MP:0005390 9.7 BMP4 DLG1 DYNC2H1 FGFR1 INTU IRF6
15 vision/eye MP:0005391 9.28 BMP4 DLG1 DYNC2H1 FGFR1 INTU MSX1

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
3
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8 Narcotics Phase 4
9 Adjuvants, Anesthesia Phase 4
10 Anesthetics Phase 4
11 Analgesics Phase 4
12 Analgesics, Opioid Phase 4
13 Anesthetics, General Phase 4
14 Anesthetics, Intravenous Phase 4
15 Central Nervous System Depressants Phase 4
16 Neurotransmitter Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Adrenergic alpha-2 Receptor Agonists Phase 4
19 Platelet Aggregation Inhibitors Phase 4
20 Excitatory Amino Acid Antagonists Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Anesthetics, Inhalation Phase 4
23 Hypnotics and Sedatives Phase 4
24 Excitatory Amino Acids Phase 4
25 Anesthetics, Dissociative Phase 4
26 Adrenergic Agents Phase 4
27
leucovorin Approved Phase 3 58-05-9 6006 143
28
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29 Trace Elements Phase 3
30 Hematinics Phase 3
31 Micronutrients Phase 3
32 Vitamins Phase 3
33 Vitamin B Complex Phase 3
34 Vitamin B9 Phase 3
35 Nutrients Phase 3
36 Folate Phase 3
37
Acetaminophen Approved Phase 2 103-90-2 1983
38
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
39
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
40 Anesthetics, Local Phase 2
41 Antipyretics Phase 2
42 abobotulinumtoxinA Phase 1, Phase 2
43 Acetylcholine Release Inhibitors Phase 1, Phase 2
44 Neuromuscular Agents Phase 1, Phase 2
45 Botulinum Toxins, Type A Phase 1, Phase 2
46 Cholinergic Agents Phase 1, Phase 2
47 Botulinum Toxins Phase 1, Phase 2
48
Morphine Approved, Investigational 57-27-2 5288826
49
Ropivacaine Approved 84057-95-4 71273 175805
50
Ferrous fumarate Approved 141-01-5

Interventional clinical trials:

(show top 50) (show all 65)
# Name Status NCT ID Phase Drugs
1 Does Sevoflurane Induce Genomic Instability in Patients Undergoing General Anaesthesia? Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
2 Opioid Free Anaesthesia vs Opioid Based Anesthesia in Cleft Lip, Palate ,Alveolus Surgery. Not yet recruiting NCT04081909 Phase 4 Fentanyl,Remifentanil;Ketamine,Dexmedetomidine
3 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
4 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
5 Clinical Evaluation of Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
6 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Recruiting NCT03766217 Phase 3
7 Velopharyngeal Function for Speech After Palatal Surgery Completed NCT00004639 Phase 2
8 Distraction Versus Orthognathic Surgery - Which One is Better for Cleft Palate Patients Completed NCT00930124 Phase 2
9 Evaluation of Postoperative Analgesic Effects of Bilateral Suprazygomatic Maxillary Nerve Block Using Bupivacaine and Dexmedetomidine in Children Undergoing Cleft Palate Repair Under General Anesthesia:Randomized Controlled Trial Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
10 Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
11 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489
12 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
13 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate: A Cross Sectional Study Unknown status NCT03219021
14 Osteogenesis and Dental Eruption Through Electrical Stimuli Following Periosteoplasty for Alveolar Clefts in Patients With Cleft Lip and Palate Deformities. A Preliminary Report. Unknown status NCT00975208
15 Distribution Of ABO Blood Groups In Relation To Cleft Lip And/or Palate . Unknown status NCT03217890
16 Stability of One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy: A Prospective Study Unknown status NCT01871623
17 Follow Ups of Parents With Infants With Cleft Lip and Palate Unknown status NCT02415361
18 Improving Outcomes in Cleft Palate Surgery Through an Audit and Feedback Intervention Directed at Surgeons Unknown status NCT02583100
19 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014
20 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
21 The Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Between Patients With and Without Pre-Alveolar Bone Graft Orthodontic Treatment Unknown status NCT02454998
22 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
23 Unilateral Cleft Repair in One Surgery With Pure Primary Healing Completed NCT04108416
24 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Completed NCT02881606
25 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Pain-related Temporomandibular Disorders Completed NCT03308266
26 Ultrasound Diagnosis of Cleft Lip and Palate - FENCHU Completed NCT03582111
27 Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients Completed NCT03686761
28 Emergence Delirium and Recovery Profile in Patients Undergoing Cleft Lip and Palate Repair: Comparison of Combination of Morphine and Fentanyl With Fentanyl Alone Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
29 Tympanometric Analysis in Post Surgical Individuals With Cleft Palate Completed NCT01820689
30 Efficacia Del Trattamento Chirurgico Maxillo-facciale Sul Volto Dei Bambini Con Labiopalatoschisi: Valutazioni Estetiche ed Ortodontiche Completed NCT03395015
31 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients. A Prospective Randomized Trial Completed NCT02329509
32 Articulatory and Phonological Competence at 3 and 5 Years of Age in Children With Unilateral Cleft Lip and Palate Who Have Undergone Different Methods of Primary Palatal Surgery Completed NCT00829101
33 Effect of A Novel (Modified Grayson) Technique for Nasoalveolar Molding and Taping on Parents' Satisfaction and Short Term Treatment Outcomes in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Controlled Trial Completed NCT02845193
34 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
35 Clinical, Volumetric and Densitometric Evaluation of Tissue Engineered (TE) Constructs for Secondary Alveolar Cleft Reconstruction (Short Term Randomized Controlled Clinical Trial) Completed NCT03563495
36 Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate Completed NCT03549039
37 Functional Outcomes of Cleft Lip and Lip Revision Surgery Completed NCT00070811
38 Comparison Between Alveolar Bone Graft With Only Cancellous Bone, and Alveolar Bone Graft With Cancellous Bone Combined With Nasal Cavity Floor's Reconstruction Using a Cortical Block Completed NCT03883373
39 OSAS in Children With Cleft Lip/Palate Completed NCT00156442
40 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
41 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
42 Transversus Abdominis Plane Block Supplementation During Iliac Crest Bone Graft Harvest - Its Influence on Postoperative Parameters Completed NCT02997124
43 Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion: A Case Series Completed NCT03976609
44 How Cerebral Oxygenation Correlates, Measured at Various Cranial Points, Frontally and Occipital in Children Under 1 Years Old, During General Anesthesia and Surgery Completed NCT03136952
45 A Comparison of the Skeletal and Dento-alveolar Changes After Treatment of Class III Malocclusion With a Modified Tandem Appliance Versus the Face Mask Completed NCT02144324
46 Evaluation of Quality of Life After Orthognathic Surgery in a Cleft Lip and Palate Context Recruiting NCT04049058
47 Three-dimensional Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty: Classic and Geometric Morphometric Evaluation Recruiting NCT03839290
48 Ex Vivo and in Vitro Assessment of the Pharmacological Properties of Molecule Prima in the Restoration of Physiological Differentiation of Gene p63 Dependant Epithelium Recruiting NCT02896387
49 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC Recruiting NCT03065686
50 Three Dimensional Analysis of Maxillofacial Growth in Patients With Cleft Lip and Palate Recruiting NCT03514563

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

40
Bone, Heart, Tongue, Lung, Skin, Eye, Testes

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 7616)
# Title Authors PMID Year
1
Current concepts on cleft lip and palate etiology. 42 61
31538461 2019
2
Jaw and Dental Abnormalities. 42
31735222 2020
3
Case report of 49,XXXXY syndrome with cleft palate, diabetes, hypothyroidism, and cataracts. 42
31574874 2019
4
Relationship of Velopharyngeal Insufficiency With Face Mask Therapy in Patients With Cleft Lip and Palate. 61
31366211 2020
5
Target Capture/Next-Generation Sequencing for Nonsyndromic Cleft Lip and Palate in the Japanese Population. 61
31337262 2020
6
Opinions of Speech-Language Pathologists Regarding Speech Management for Children With Cleft Lip and Palate. 61
31220929 2020
7
Dental Anomalies in Permanent Teeth Associated With Nonsyndromic Cleft Lip and Palate in a Group of Colombian Children. 61
31284730 2020
8
Association between MSX1 rs12532 polymorphism with nonsyndromic unilateral complete cleft lip and palate and tooth agenesis. 61
31568994 2020
9
Lipofilling in patients with a cleft lip (and palate) - a pilot study assessing functional outcomes and patients' satisfaction with appearance. 61
31568953 2020
10
Evaluation of Postorthodontic Changes in the Treatment of Cleft Lip and Palate Patients Using the PAR Index. 61
31514510 2020
11
The Contribution of a Charitable Organization to Regional Cleft Lip and Palate Services in England and Scotland. 61
31307213 2020
12
Effects of Different Timing of Alveolar Bone Graft on Craniofacial Morphology in Unilateral Cleft Lip and Palate. 61
31370693 2020
13
Is There a Correlation Between Nasolabial Appearance and Dentoalveolar Relationships in Patients With Repaired Unilateral Cleft Lip and Palate? 61
31331191 2020
14
Closer to the Truth on National Fistula Prevalence After Unilateral Complete Cleft Lip and Palate Repair? The Cleft Care UK Study. 61
31248277 2020
15
Cone-Beam Computed Tomography Evaluation of Skeletal Deformities and Pharyngeal Airway in Chinese Han Individuals With Nonsyndromic Unilateral Cleft Lip and Palate. 61
31296040 2020
16
Novel synonymous and missense variants in FGFR1 causing Hartsfield syndrome. 61
31512363 2019
17
Morphological variability in unrepaired bilateral clefts with and without cleft palate evaluated with geometric morphometrics. 61
31792971 2019
18
Analysis of the Prevalence and Incidence of Cleft Lip and Palate in Colombia. 61
31795734 2019
19
Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis. 61
31271540 2019
20
OrthoAligner "NAM": A Case Series of Presurgical Infant Orthopedics (PSIO) Using Clear Aligneres. 61
31795731 2019
21
Stem cell-derived conditioned media from human exfoliated deciduous teeth promotes bone regeneration. 61
31808229 2019
22
Leveraging Family History in Case-Control Analyses of Rare Variation. 61
31843756 2019
23
Nonlinear gene expression-phenotype relationships contribute to variation and clefting in the A/WySn mouse. 61
31469941 2019
24
Tetrasomy 21 pter→q21.3 due to an extra +dic(21;21)mat in a severely psychomotor-retarded female patient without down syndrome phenotype. 61
31830537 2019
25
Phenotypic spectrum associated with SPECC1L pathogenic variants: new families and critical review of the nosology of Teebi, Opitz GBBB, and Baraitser-Winter syndromes. 61
30472488 2019
26
Prenatal evaluation of the Sakoda complex. 61
31384970 2019
27
Association between cystathionine beta-synthase c.844ins68 polymorphism and risk of non-syndromic cleft lip/palate: A meta-analysis of family-based and case-control studies. 61
31495752 2019
28
Evaluation of a Digital Protocol for Pre-Surgical Orthopedic Treatment of Cleft Lip and Palate in Newborn Patients: A Pilot Study. 61
31835442 2019
29
Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals. 61
30815431 2019
30
Association of Betaine-Homocysteine S-Methyl Transferase (rs3797546 and rs3733890) polymorphisms with non-syndromic cleft lip/palate: A meta-analysis. 61
31451344 2019
31
Letter to the Editor: Design and fabrication of a generic 3D-printed silicone unilateral cleft lip and palate model. 61
31843387 2019
32
Modern Surgery-First Approach Concept in Cleft-Orthognathic Surgery: A Comparative Cohort Study with 3D Quantitative Analysis of Surgical-Occlusion Setup. 61
31810279 2019
33
Occlusion at 5 Years of Age Following Hard Palate Closure With Vestibular Flap. 61
31847566 2019
34
Lag screw fixation of the premaxilla during bilateral cleft lip repair. 61
31812313 2019
35
PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate. 61
31825181 2019
36
Outcomes of Maxillary Orthognathic Surgery in Patients with Cleft Lip and Palate: A Literature Review. 61
31624427 2019
37
Facial aesthetic evaluation in patients with repaired cleft lip and palate. 61
31218214 2019
38
Effect on Facial Growth of the Management of Cleft Lip and Palate. 61
30882417 2019
39
Wharton's Jelly for Augmented Cleft Palate Repair in a Rat Critical Size Alveolar Bone Defect Model. 61
31739755 2019
40
Interferon regulatory factor 6 is required for proper wound healing in vivo. 61
31724286 2019
41
The functional variant of NTN1 contributes to the risk of nonsyndromic cleft lip with or without cleft palate. 61
31780810 2019
42
Non-Interventional Factors Influencing Velopharyngeal Function For Speech In Initial Cleft Palate Repair: A Systematic Review Protocol. 61
31690349 2019
43
Predictors of Velopharyngeal Dysfunction in Individuals With Cleft Palate Following Surgical Maxillary Advancement: Clinical and Tomographic Assessments. 61
31213072 2019
44
Association of single nucleotide polymorphisms at 20q12 with nonsyndromic cleft lip with or without cleft palate in a Southern Chinese Han cohort. 61
31713353 2019
45
Impact of speech rate and mouth opening on hypernasality and speech intelligibility in children with a cleft (lip and) palate. 61
31739225 2019
46
Early outcomes of cleft and palatal width following anterior palate repair (vomerine flap) in infants with wide cleft lip and palate. 61
31775204 2019
47
Scandcleft Project, Trial 1: Comparison of Speech Outcome in Relation to Timing of Hard Palate Closure in 5-Year-Olds With UCLP. 61
31189334 2019
48
Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate. 61
31306378 2019
49
Analysis of Dental Arch in Children With Oral Cleft Before and After the Primary Surgeries. 61
31369497 2019
50
Fabrication of Nasoalveolar Molding Devices for the Treatment of Cleft Lip and Palate, Using Stereolithography Additive Manufacturing Processes and Computer-Aided Design Manipulation Software. 61
31584552 2019

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

Pathways related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.06 TGFA FGFR1 DLG1 CDH1 BMP4
2 11.75 YAP1 DLG1 CDH1 BMP4
3 11.58 TP63 MSX1 IRF6 BMP4
4 11.35 NECTIN1 FGFR1 CDH1
5 11.27 MSX1 FGFR1 CDH1 BMP4
6 9.7 TP63 IRF6 ARHGAP29

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical junction complex GO:0043296 8.62 NECTIN1 CDH1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.03 TP63 MSX1 FGFR1 DLX4 DLG1 BMP4
2 positive regulation of transcription, DNA-templated GO:0045893 10.02 YAP1 TP63 IRF6 CDH1 BMP4
3 positive regulation of cell proliferation GO:0008284 9.99 YAP1 TGFA FGFR1 DLG1 BMP4
4 regulation of gene expression GO:0010468 9.88 YAP1 FGFR1 CDH1 BMP4
5 cell morphogenesis GO:0000902 9.77 YAP1 MSX1 CDH1
6 forebrain development GO:0030900 9.69 MSX1 DYNC2H1 BMP4
7 odontogenesis of dentin-containing tooth GO:0042475 9.67 TP63 MSX1 BMP4
8 embryonic morphogenesis GO:0048598 9.63 MSX1 BMP4
9 middle ear morphogenesis GO:0042474 9.62 MSX1 FGFR1
10 anatomical structure formation involved in morphogenesis GO:0048646 9.61 TP63 BMP4
11 establishment of planar polarity GO:0001736 9.61 TP63 INTU
12 embryonic digit morphogenesis GO:0042733 9.61 MSX1 INTU BMP4
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.58 MSX1 BMP4
14 organ induction GO:0001759 9.57 FGFR1 BMP4
15 smooth muscle tissue development GO:0048745 9.55 DLG1 BMP4
16 intraciliary retrograde transport GO:0035721 9.54 WDR35 DYNC2H1
17 ureteric bud development GO:0001657 9.54 FGFR1 DLG1 BMP4
18 paraxial mesoderm development GO:0048339 9.52 YAP1 FGFR1
19 bud elongation involved in lung branching GO:0060449 9.48 YAP1 BMP4
20 astral microtubule organization GO:0030953 9.46 DLG1 CEP120
21 pituitary gland development GO:0021983 9.43 MSX1 CDH1 BMP4
22 BMP signaling pathway involved in heart development GO:0061312 9.4 MSX1 BMP4
23 embryonic hindlimb morphogenesis GO:0035116 9.33 TP63 MSX1 BMP4
24 cloacal septation GO:0060197 9.32 TP63 BMP4
25 keratinocyte differentiation GO:0030216 9.26 YAP1 TP63 IRF6 INTU
26 embryonic limb morphogenesis GO:0030326 9.02 TP63 MSX1 FGFR1 DYNC2H1 BMP4

Sources for Cleft Lip/palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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