Cleft Lip/palate (FLP)

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Cleft Lip/palate

Summaries for Cleft Lip/palate

MedlinePlus : 43 Cleft lip and cleft palate are birth defects that occur when a baby's lip or mouth do not form properly. They happen early during pregnancy. A baby can have a cleft lip, a cleft palate, or both. A cleft lip happens if the tissue that makes up the lip does not join completely before birth. This causes an opening in the upper lip. The opening can be a small slit or a large opening that goes through the lip into the nose. It can be on one or both sides of the lip or, rarely, in the middle of the lip. Children with a cleft lip also can have a cleft palate. The roof of the mouth is called the "palate." With a cleft palate, the tissue that makes up the roof of the mouth does not join correctly. Babies may have both the front and back parts of the palate open, or they may have only one part open. Children with a cleft lip or a cleft palate often have problems with feeding and talking. They also might have ear infections, hearing loss, and problems with their teeth. Often, surgery can close the lip and palate. Cleft lip surgery is usually done before age 12 months, and cleft palate surgery is done before 18 months. Many children have other complications. They may need additional surgeries, dental and orthodontic care, and speech therapy as they get older. With treatment, most children with clefts do well and lead a healthy life. Centers for Disease Control and Prevention

MalaCards based summary : Cleft Lip/palate, also known as cleft lip and palate, is related to ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 and short-rib thoracic dysplasia 7 with or without polydactyly. An important gene associated with Cleft Lip/palate is DLX4 (Distal-Less Homeobox 4), and among its related pathways/superpathways are Signaling by Hedgehog and Hippo signaling pathway. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and tongue, and related phenotypes are dental malocclusion and delayed speech and language development

Related Diseases for Cleft Lip/palate

Diseases related to Cleft Lip/palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 1 35.0 TP63 EEC1
2 short-rib thoracic dysplasia 7 with or without polydactyly 33.3 WDR35 INTU
3 short-rib thoracic dysplasia 3 with or without polydactyly 32.8 WDR35 DYNC2LI1 DYNC2H1 CEP120
4 bartsocas-papas syndrome 32.7 TP63 IRF6
5 short-rib thoracic dysplasia 1 with or without polydactyly 32.5 WDR35 IFT140 DYNC2LI1 DYNC2H1 CEP120
6 isolated cleft lip 31.8 TP63 NECTIN1 MSX1 IRF6
7 cleft lip and alveolus 31.3 TP63 NECTIN1 MSX1 IRF6
8 tooth size 30.7 MSX1 BMP4
9 cleft palate, isolated 30.5 TP63 NECTIN1 MSX1 IRF6 FGFR1 BMP4
10 orofacial cleft 29.8 TP63 NECTIN1 MSX1 IRF6 DLX4 BMP4
11 tooth agenesis 29.6 MSX1 IRF6 FGFR1 CDH1 BMP4
12 cleft lip 29.5 TP63 NECTIN1 MSX1 IRF6 FGFR1 DLX4
13 cleft lip/palate-ectodermal dysplasia syndrome 13.1
14 ankyloblepharon-ectodermal defects-cleft lip/palate 13.1
15 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 13.0
16 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 13.0
17 arthrogryposis, ectodermal dysplasia, cleft lip/palate, and developmental delay 13.0
18 microcephaly, corpus callosum dysgenesis, and cleft lip/palate 12.7
19 cleft lip/palate with abnormal thumbs and microcephaly 12.6
20 ectrodactyly and ectodermal dysplasia without cleft lip/palate 12.6
21 cleft lip/palate with characteristic facies, intestinal malrotation, and lethal congenital heart disease 12.6
22 radius, aplasia of, with cleft lip/palate 12.5
23 hypotrichosis, progressive patterned scalp, with wiry hair, onycholysis, and cleft lip/palate 12.5
24 cleft lip palate dysmorphism kumar type 12.5
25 cleft lip palate oligodontia syndactyly pili torti 12.5
26 cleft lip palate pituitary deficiency 12.5
27 cleft lip palate-tetraphocomelia 12.5
28 craniosynostosis cleft lip palate arthrogryposis 12.5
29 holoprosencephaly ectrodactyly cleft lip palate 12.5
30 syndactyly ectodermal dysplasia cleft lip palate hand foot 12.5
31 cleft lip/palate-deafness-sacral lipoma syndrome 12.5
32 cleft lip and palate malrotation cardiopathy 12.5
33 cleft lip and palate-craniofacial dysmorphism-congenital heart defect-hearing loss syndrome 12.5
34 rapp-hodgkin syndrome 12.4
35 popliteal pterygium syndrome 12.4
36 hartsfield syndrome 12.3
37 cleft palate, cardiac defects, and mental retardation 12.3
38 vici syndrome 12.3
39 orofaciodigital syndrome vi 12.2
40 richieri-costa/guion-almeida syndrome 12.2
41 acrofrontofacionasal dysostosis 12.2
42 pilotto syndrome 12.1
43 zlotogora syndrome 12.1
44 orofacial cleft 1 12.0
45 acrofrontofacionasal dysostosis 1 12.0
46 cleft palate, cardiac defect, genital anomalies, and ectrodactyly 11.9
47 fryns microphthalmia syndrome 11.8
48 van der woude syndrome 1 11.8
49 martinez monasterio pinheiro syndrome 11.8
50 olivopontocerebellar atrophy 11.8

Graphical network of the top 20 diseases related to Cleft Lip/palate:

Diseases related to Cleft Lip/palate

Symptoms & Phenotypes for Cleft Lip/palate

Human phenotypes related to Cleft Lip/palate:

59 (show all 21)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dental malocclusion 59 Occasional (29-5%)
2 delayed speech and language development 59 Frequent (79-30%)
3 feeding difficulties in infancy 59 Frequent (79-30%)
4 cleft palate 59 Frequent (79-30%)
5 recurrent otitis media 59 Frequent (79-30%)
6 hypoplasia of the maxilla 59 Very rare (<4-1%)
7 conductive hearing impairment 59 Occasional (29-5%)
8 nasal speech 59 Occasional (29-5%)
9 oral cleft 59 Frequent (79-30%)
10 poor suck 59 Frequent (79-30%)
11 velopharyngeal insufficiency 59 Frequent (79-30%)
12 speech articulation difficulties 59 Frequent (79-30%)
13 abnormality of dental eruption 59 Very frequent (99-80%)
14 unilateral cleft palate 59 Frequent (79-30%)
15 oral-pharyngeal dysphagia 59 Frequent (79-30%)
16 malnutrition 59 Occasional (29-5%)
17 peg-shaped maxillary lateral incisors 59 Occasional (29-5%)
18 palate fistula 59 Occasional (29-5%)
19 abnormal number of permanent teeth 59 Occasional (29-5%)
20 bilateral cleft palate 59 Occasional (29-5%)
21 agenesis of lateral incisor 59 Occasional (29-5%)

MGI Mouse Phenotypes related to Cleft Lip/palate:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.4 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
2 embryo MP:0005380 10.39 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
3 cellular MP:0005384 10.36 BMP4 CDH1 CEP120 DLG1 DYNC2H1 DYNC2LI1
4 cardiovascular system MP:0005385 10.34 BMP4 CDH1 CEP120 DYNC2H1 DYNC2LI1 FGFR1
5 homeostasis/metabolism MP:0005376 10.32 BMP4 CDH1 DLG1 DYNC2LI1 FGFR1 IFT140
6 mortality/aging MP:0010768 10.31 ARHGAP29 BMP4 CDH1 CEP120 DLG1 DYNC2H1
7 digestive/alimentary MP:0005381 10.3 ARHGAP29 BMP4 CDH1 DLG1 DYNC2H1 FGFR1
8 craniofacial MP:0005382 10.24 ARHGAP29 BMP4 DLG1 DYNC2H1 FGFR1 IFT140
9 limbs/digits/tail MP:0005371 10.17 BMP4 DLG1 DYNC2H1 DYNC2LI1 FGFR1 IFT140
10 integument MP:0010771 10.06 BMP4 CDH1 FGFR1 IRF6 MSX1 NECTIN1
11 nervous system MP:0003631 10.06 BMP4 CEP120 DLG1 DYNC2H1 DYNC2LI1 FGFR1
12 muscle MP:0005369 9.91 BMP4 DLG1 FGFR1 MSX1 TP63 WDR35
13 renal/urinary system MP:0005367 9.86 BMP4 DLG1 DYNC2H1 FGFR1 IFT140 INTU
14 respiratory system MP:0005388 9.76 BMP4 DLG1 DYNC2H1 IFT140 MSX1 TP63
15 skeleton MP:0005390 9.7 BMP4 DLG1 DYNC2H1 FGFR1 IFT140 INTU
16 vision/eye MP:0005391 9.28 BMP4 DLG1 DYNC2H1 FGFR1 IFT140 INTU

Drugs & Therapeutics for Cleft Lip/palate

Drugs for Cleft Lip/palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
3 Central Nervous System Depressants Phase 4
4 Anesthetics Phase 4
5 Anesthetics, General Phase 4
6 Anesthetics, Intravenous Phase 4
7 Hypnotics and Sedatives Phase 4
8 Platelet Aggregation Inhibitors Phase 4
9 Anesthetics, Inhalation Phase 4
leucovorin Approved Phase 3 58-05-9 143 6006
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
12 Micronutrients Phase 3
13 Hematinics Phase 3
14 Trace Elements Phase 3
15 Vitamins Phase 3
16 Vitamin B9 Phase 3
17 Vitamin B Complex Phase 3
18 Nutrients Phase 3
19 Folate Phase 3
Dexmedetomidine Approved, Vet_approved Phase 2 113775-47-6 68602 5311068
Acetaminophen Approved Phase 2 103-90-2 1983
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
Acetylcholine Approved, Investigational Phase 1, Phase 2 51-84-3 187
24 Analgesics Phase 2
25 Anesthetics, Local Phase 2
26 Analgesics, Non-Narcotic Phase 2
27 Adrenergic alpha-2 Receptor Agonists Phase 2
28 Adrenergic Agonists Phase 2
29 Adrenergic alpha-Agonists Phase 2
30 Adrenergic Agents Phase 2
31 Antipyretics Phase 2
32 Peripheral Nervous System Agents Phase 1, Phase 2
33 Neurotransmitter Agents Phase 1, Phase 2
34 Neuromuscular Agents Phase 1, Phase 2
35 Cholinergic Agents Phase 1, Phase 2
36 abobotulinumtoxinA Phase 1, Phase 2
37 Acetylcholine Release Inhibitors Phase 1, Phase 2
38 Botulinum Toxins Phase 1, Phase 2
39 Botulinum Toxins, Type A Phase 1, Phase 2
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
Morphine Approved, Investigational 57-27-2 5288826
Ropivacaine Approved 84057-95-4 71273 175805
Ferrous fumarate Approved 141-01-5
Racepinephrine Approved 329-65-7 838
Epinephrine Approved, Vet_approved 51-43-4 5816
tannic acid Approved 1401-55-4
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
48 Narcotics
49 Adjuvants, Anesthesia
50 Analgesics, Opioid

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Does Sevoflurane Induce Genomic Instability in Patients Undergoing General Anaesthesia? Recruiting NCT03109119 Phase 4 Sevoflurane;Propofol
2 Oral Cleft Prevention Program Completed NCT00397917 Phase 3 Folic acid: 4 mg versus 0.4 mg per day
3 Oral Cleft Prevention Trial in Brazil Completed NCT00098319 Phase 3 Folic acid (0.4mg vs. 4.0mg)
4 Clinical Evaluation of Silicone Gel in the Treatment of Cleft Lip Scars Completed NCT03314090 Phase 3 Silicone Gels
5 Bone Tissue Engineering With Dental Pulp Stem Cells for Alveolar Cleft Repair Not yet recruiting NCT03766217 Phase 3
6 Velopharyngeal Function for Speech After Palatal Surgery Completed NCT00004639 Phase 2
7 Distraction Versus Orthognathic Surgery - Which One is Better for Cleft Palate Patients Completed NCT00930124 Phase 2
8 Evaluation of Postoperative Analgesic Effects of Bilateral Suprazygomatic Maxillary Nerve Block Using Bupivacaine and Dexmedetomidine in Children Undergoing Cleft Palate Repair Under General Anesthesia:Randomized Controlled Trial Completed NCT03412474 Phase 2 Bupivacaine;Dexmedetomidine;paracetamol
9 Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair Recruiting NCT02247193 Phase 1, Phase 2 Botulinum Toxin Type A;Normal Saline Injection
10 Parent's Satisfaction and Evaluation of Postsurgical Outcomes in Unilateral Cleft Lip / Palate Newly Born Infants With / Without Vacuum Formed Nasoalveolar Molding Aligners : A Controlled Clinical Trial Unknown status NCT03011489
11 Functional Nasal Surgery at the Time of Le Fort I Osteotomy: A Prospective, Single-blind, Randomized Trial Unknown status NCT01883687
12 Evaluation of Arch Dimensions of Children With Surgically Repaired Unilateral Cleft Lip and Palate: A Cross Sectional Study Unknown status NCT03219021
13 Osteogenesis and Dental Eruption Through Electrical Stimuli Following Periosteoplasty for Alveolar Clefts in Patients With Cleft Lip and Palate Deformities. A Preliminary Report. Unknown status NCT00975208
14 Distribution Of ABO Blood Groups In Relation To Cleft Lip And/or Palate . Unknown status NCT03217890
15 Stability of One-Piece Le Fort I Osteotomy Versus Segmental Le Fort I Osteotomy: A Prospective Study Unknown status NCT01871623
16 Validation of a Production Method of Stem Cell Isolated From the Nasal Cavity for an Innovative Cell Therapy of Cleft Palate Unknown status NCT02900014
17 Improving Outcomes in Cleft Palate Surgery Through an Audit and Feedback Intervention Directed at Surgeons Unknown status NCT02583100
18 Inferior Alveolar Nerve Injury After Bilateral Sagittal Split Osteotomy in Oral Clefts Unknown status NCT01875965
19 The Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Between Patients With and Without Pre-Alveolar Bone Graft Orthodontic Treatment Unknown status NCT02454998
20 Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients Completed NCT01932164
21 Electromyographic Analysis of the Masticatory Muscles in Cleft Lip and Palate Children With Pain-related Temporomandibular Disorders Completed NCT03308266
22 Ultrasound Diagnosis of Cleft Lip and Palate - FENCHU Completed NCT03582111
23 Periodontal Changes and Gingival Soft Tissue Healing Following Mid Maxillary Distraction in Cleft Lip and Palate Patients Completed NCT03686761
24 Emergence Delirium and Recovery Profile in Patients Undergoing Cleft Lip and Palate Repair: Comparison of Combination of Morphine and Fentanyl With Fentanyl Alone Completed NCT03010540 MORPHINE PLUS FENTANYL;Fentanyl
25 Tympanometric Analysis in Post Surgical Individuals With Cleft Palate Completed NCT01820689
26 Articulatory and Phonological Competence at 3 and 5 Years of Age in Children With Unilateral Cleft Lip and Palate Who Have Undergone Different Methods of Primary Palatal Surgery Completed NCT00829101
27 Evaluation of Facial Growth in Two Primary Protocols Used in the Surgical Treatment of Unilateral Cleft Lip and Palate Patients. A Prospective Randomized Trial Completed NCT02329509
28 Efficacia Del Trattamento Chirurgico Maxillo-facciale Sul Volto Dei Bambini Con Labiopalatoschisi: Valutazioni Estetiche ed Ortodontiche Completed NCT03395015
29 Effect of A Novel (Modified Grayson) Technique for Nasoalveolar Molding and Taping on Parents' Satisfaction and Short Term Treatment Outcomes in Infants With Unilateral Complete Cleft Lip and Palate: A Randomized Controlled Trial Completed NCT02845193
30 Systematic Pediatric Care for Oral Clefts - South America Completed NCT00097149
31 Comparison Between Alveolar Bone Graft With Only Cancellous Bone, and Alveolar Bone Graft With Cancellous Bone Combined With Nasal Cavity Floor's Reconstruction Using a Cortical Block Completed NCT03883373
32 Effect of Alveolar Bone Grafting on Health Quality in Patients With Cleft Lip and Palate Completed NCT03549039
33 Clinical, Volumetric and Densitometric Evaluation of Tissue Engineered (TE) Constructs for Secondary Alveolar Cleft Reconstruction (Short Term Randomized Controlled Clinical Trial) Completed NCT03563495
34 Functional Outcomes of Cleft Lip and Lip Revision Surgery Completed NCT00070811
35 Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environment) Completed NCT00340977
36 Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences Completed NCT00340964
37 Transversus Abdominis Plane Block Supplementation During Iliac Crest Bone Graft Harvest - Its Influence on Postoperative Parameters Completed NCT02997124
38 Three Dimensional Changes on Nasal Septum and Alveolar Cleft After Maxillary Expansion: A Case Series Completed NCT03976609
39 How Cerebral Oxygenation Correlates, Measured at Various Cranial Points, Frontally and Occipital in Children Under 1 Years Old, During General Anesthesia and Surgery Completed NCT03136952
40 A Comparison of the Skeletal and Dento-alveolar Changes After Treatment of Class III Malocclusion With a Modified Tandem Appliance Versus the Face Mask Completed NCT02144324
41 Evaluation of the Clinical Effectiveness of Naso-alveolar Molding (NAM) Versus Computer Aided Design NAM (CAD/NAM) in Infants With Bilateral Cleft Lip and Palate: A Randomized Clinical Trial Recruiting NCT02881606
42 Three-dimensional Development of the Palate in Bilateral Orofacial Cleft Newborns One Year After Early Neonatal Cheiloplasty: Classic and Geometric Morphometric Evaluation Recruiting NCT03839290
43 Ex Vivo and in Vitro Assessment of the Pharmacological Properties of Molecule Prima in the Restoration of Physiological Differentiation of Gene p63 Dependant Epithelium Recruiting NCT02896387
44 Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing GENEPIC Recruiting NCT03065686
45 Otologic and Rhinologic Outcomes in Children With Cleft Palate at Age 10 Years Recruiting NCT03708406
46 Implementation of a Learning Health-care System at the Duke Cleft & Craniofacial Center to Enable Comprehensive Appraisal of Cleft Care for Outcomes Assessment, Comparative Effectiveness Research, and Quality Assurance and Improvement Recruiting NCT02702869
47 Three Dimensional Analysis of Maxillofacial Growth in Patients With Cleft Lip and Palate Recruiting NCT03514563
48 Extended Criteria For Fetal Myelomeningocele Repair: A Pilot Study Recruiting NCT02664207
49 Use of Cleft Margin Flap With Anterior Palatal Closure for Closure of Naso-alveolar Defect During Primary Cleft Lip Repair (Pilot Study). Recruiting NCT03922438
50 Clinical Effectiveness of Late Maxillary Protraction for Cleft Lip and Palate Active, not recruiting NCT02789787

Search NIH Clinical Center for Cleft Lip/palate

Genetic Tests for Cleft Lip/palate

Genetic tests related to Cleft Lip/palate:

# Genetic test Affiliating Genes
1 Cleft Lip/palate 29

Anatomical Context for Cleft Lip/palate

MalaCards organs/tissues related to Cleft Lip/palate:

Bone, Heart, Tongue, Lung, Skin, Testes, Eye

Publications for Cleft Lip/palate

Articles related to Cleft Lip/palate:

(show top 50) (show all 7501)
# Title Authors PMID Year
Dental development in cleft lip and palate patients: A systematic review. 38 17
31075568 2019
Correction of labial tubercle defect in repaired bilateral cleft lips using bilateral vermilion musculomucosal sliding flaps: Case series. 17
31335670 2019
Investigation of candidate genes of non-syndromic cleft lip with or without cleft palate, using both case-control and family-based association studies. 17
31261547 2019
Facial aesthetic evaluation in patients with repaired cleft lip and palate. 38
31218214 2019
Evaluation of facial appearance in patients with repaired cleft lip and palate: comparing the assessment of laypeople and healthcare professionals. 38
30815431 2019
Cleft Palate Outcomes and Prognostic Impact of Palatal Fistula on Subsequent Velopharyngeal Function-A Retrospective Cohort Study. 38
30755029 2019
Assessing health-related quality of life in patients with cleft palate in resource-limited countries: A preliminary evaluation of the VELO questionnaire in Uganda. 38
31158570 2019
The use of Medpor implants for midface contouring in cleft patients. 38
30871847 2019
Evaluation of the Effects of Cheiloplasty on Maxillary Arch in UCLP Infants Using Three-Dimensional Digital Models. 38
30832519 2019
A Bibliometric Analysis of the Most Cited Articles in Global Reconstructive Surgery. 38
30882407 2019
A systematic genetic analysis and visualization of phenotypic heterogeneity among orofacial cleft GWAS signals. 38
31172578 2019
Dentoalveolar Arch Dimensions in UCLP Boys After Neonatal Cheiloplasty or After Lip Surgery at the Age of 3 or 6 Months. 38
30696266 2019
Achiasma and Kapur-Toriello syndrome: Two rare entities. 38
31245653 2019
Intraoral Digital Impression Technique for a Neonate With Bilateral Cleft Lip and Palate. 38
30857398 2019
A Pristine Approach for the Prominent Premaxilla in Bilateral Cleft Lip and Palate (BCLP) Cases. 38
30866673 2019
Effect of the Visual Presentation of a Craniofacial Syndrome on Speech Intelligibility in Noise. 38
30669867 2019
The Difficult Route to Glottis in Cleft Patients Simplified. 38
31371894 2019
ABM Clinical Protocol #17: Guidelines for Breastfeeding Infants with Cleft Lip, Cleft Palate, or Cleft Lip and Palate-Revised 2019. 38
31408356 2019
[Application of mathematical function model in morphological description and classification of bone defect in cleft palate cases]. 38
31378033 2019
Effects of pre-gestational diabetes mellitus and gestational diabetes mellitus on macrosomia and birth defects in Upstate New York. 38
31401151 2019
A novel mutation (c.1010G>T; p.R337L) in TP63 as a cause of split-hand/foot malformation with hypodontia. 38
31420900 2019
Upper airway in children with unilateral cleft lip and palate evaluated with computational fluid dynamics. 38
31375236 2019
Parent Perceptions of Initial Feeding Experiences of Children Born With Cleft Palate in a Rural Locale. 38
30587009 2019
Retrospective Comparison of 2 Management Strategies for Perioperative Malaria Episodes in Pediatric Patients in a Limited-Resource Setting. 38
31314746 2019
Comparative Outcomes of Block and Cancellous Iliac Bone Grafting in Older Unilateral Alveolar Cleft Patients. 38
30621447 2019
Management of the protuberant premaxilla: where does it fit in? 38
31219831 2019
Confirmation and further delineation of the SMG9-deficiency syndrome, a rare and severe developmental disorder. 38
31390136 2019
Bone Regeneration in a Canine Model of Artificial Jaw Cleft Using Bone Marrow-Derived Mesenchymal Stem Cells and Carbonate Hydroxyapatite Carrier. 38
31422673 2019
Rapid maxillary expansion effects of nasal airway in children with cleft lip and palate using computational fluid dynamics. 38
30912603 2019
Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft? 38
31226652 2019
Adherence to Orthodontic Treatment in Youth With Cleft Lip and/or Palate. 38
31394915 2019
Word Reading in Boys With Isolated Oral Clefts: Comparison to Unaffected Average and Dyslexic Readers Using the Dual-Route Model. 38
31370691 2019
Intensive speech therapy in Ugandan patients with cleft (lip and) palate: a pilot-study assessing long-term effectiveness. 38
31112839 2019
Case series: Amniotic band sequence with craniofacial abnormalities. 38
31407870 2019
Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome. 38
31413199 2019
Fetal MRI findings in a retrospective cohort of 26 cases of prenatally diagnosed CHARGE syndrome individuals. 38
30715739 2019
Orofacial features and medical profile of eight individuals with Kabuki syndrome. 38
31433389 2019
Acoustic analysis of voice in children with cleft lip and palate following vocal rehabilitation. Preliminary report. 38
31394406 2019
Risk factors for velopharyngeal dysfunction following orthognathic surgery in the cleft population. 38
31274569 2019
Prenatal evaluation of the Sakoda complex. 38
31384970 2019
Decision-Making in Cleft-Related Surgery: A Qualitative Analysis of Patients and Caregivers. 38
31382774 2019
Nasolabial outcomes in a nationwide study of orofacial cleft in New Zealand. 38
30849215 2019
Apical root resorption after orthodontic treatment in patients with unilateral cleft lip and palate. 38
31410675 2019
Polymorphic Variants of V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog B (rs13041247 and rs11696257) and Risk of Non-Syndromic Cleft Lip/Palate: Systematic Review and Meta-Analysis. 38
31387249 2019
Eighteen-Year Follow-Up of 160 Consecutive Individuals Born With Unilateral Cleft Lip or Cleft Lip and Alveolus Treated by the Oslo Cleft Lip and Palate Team. 38
30686058 2019
Effects of Different Timing of Alveolar Bone Graft on Craniofacial Morphology in Unilateral Cleft Lip and Palate. 38
31370693 2019
Patients With Cleft Lip and Palate Associated With Intraoral Fibrous Bands: A Report of 3 Cases and Review of Literature. 38
31378081 2019
Early Weight Gain in Infants With Cleft Lip and Palate Treated With and Without Nasoalveolar Molding: A Retrospective Study. 38
30514093 2019
Clinical Outcomes Utilizing a "Modified Latham" Appliance for Presurgical Infant Orthopedics in Patients With Unilateral Complete Cleft Lip and Palate. 38
30526003 2019
Pilot Study of Visual and Quantitative Image Analysis of Facial Surface Asymmetry in Unilateral Complete Cleft Lip and Palate. 38
30587013 2019

Variations for Cleft Lip/palate

Expression for Cleft Lip/palate

Search GEO for disease gene expression data for Cleft Lip/palate.

Pathways for Cleft Lip/palate

GO Terms for Cleft Lip/palate

Cellular components related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cilium GO:0005929 9.71 WDR35 IFT140 DYNC2LI1 DYNC2H1
2 motile cilium GO:0031514 9.61 INTU DYNC2LI1 DYNC2H1
3 ciliary basal body GO:0036064 9.46 WDR35 INTU IFT140 DYNC2LI1
4 apical junction complex GO:0043296 9.37 NECTIN1 CDH1
5 cytoplasmic dynein complex GO:0005868 9.32 DYNC2LI1 DYNC2H1
6 intraciliary transport particle A GO:0030991 9.26 WDR35 IFT140
7 axoneme GO:0005930 9.26 WDR35 IFT140 DYNC2LI1 DYNC2H1
8 ciliary tip GO:0097542 8.92 WDR35 IFT140 DYNC2LI1 DYNC2H1

Biological processes related to Cleft Lip/palate according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.91 MSX1 IFT140 DYNC2H1 BMP4
2 determination of left/right symmetry GO:0007368 9.78 IFT140 DYNC2LI1 DYNC2H1
3 cilium assembly GO:0060271 9.77 WDR35 INTU IFT140 DYNC2LI1 DYNC2H1
4 forebrain development GO:0030900 9.76 MSX1 DYNC2H1 BMP4
5 odontogenesis of dentin-containing tooth GO:0042475 9.72 TP63 MSX1 BMP4
6 cell projection organization GO:0030030 9.72 WDR35 INTU IFT140 DYNC2LI1 DYNC2H1
7 keratinocyte differentiation GO:0030216 9.71 YAP1 TP63 IRF6 INTU
8 non-motile cilium assembly GO:1905515 9.7 INTU IFT140 DYNC2H1
9 ureteric bud development GO:0001657 9.69 FGFR1 DLG1 BMP4
10 renal system development GO:0072001 9.65 IFT140 BMP4
11 anatomical structure formation involved in morphogenesis GO:0048646 9.65 TP63 BMP4
12 camera-type eye morphogenesis GO:0048593 9.65 NECTIN1 BMP4
13 pituitary gland development GO:0021983 9.65 MSX1 CDH1 BMP4
14 middle ear morphogenesis GO:0042474 9.64 MSX1 FGFR1
15 establishment of planar polarity GO:0001736 9.63 TP63 INTU
16 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.63 MSX1 BMP4
17 protein localization to cilium GO:0061512 9.63 WDR35 IFT140 DYNC2H1
18 smooth muscle tissue development GO:0048745 9.62 DLG1 BMP4
19 organ induction GO:0001759 9.62 FGFR1 BMP4
20 embryonic hindlimb morphogenesis GO:0035116 9.61 TP63 MSX1 BMP4
21 paraxial mesoderm development GO:0048339 9.59 YAP1 FGFR1
22 bud elongation involved in lung branching GO:0060449 9.57 YAP1 BMP4
23 astral microtubule organization GO:0030953 9.56 DLG1 CEP120
24 embryonic digit morphogenesis GO:0042733 9.56 MSX1 INTU IFT140 BMP4
25 BMP signaling pathway involved in heart development GO:0061312 9.54 MSX1 BMP4
26 cloacal septation GO:0060197 9.49 TP63 BMP4
27 intraciliary transport involved in cilium assembly GO:0035735 9.46 WDR35 IFT140 DYNC2LI1 DYNC2H1
28 embryonic limb morphogenesis GO:0030326 9.35 TP63 MSX1 FGFR1 DYNC2H1 BMP4
29 intraciliary retrograde transport GO:0035721 8.92 WDR35 IFT140 DYNC2LI1 DYNC2H1
30 multicellular organism development GO:0007275 10.12 TP63 MSX1 INTU DYNC2LI1 DYNC2H1 DLX4
31 negative regulation of transcription by RNA polymerase II GO:0000122 10.08 TP63 MSX1 FGFR1 DLX4 DLG1 BMP4
32 positive regulation of transcription, DNA-templated GO:0045893 10.04 YAP1 TP63 IRF6 CDH1 BMP4

Molecular functions related to Cleft Lip/palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 8.62 DYNC2LI1 DYNC2H1

Sources for Cleft Lip/palate

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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